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Paul R. Ortiz de Montellano - Publications

Affiliations: 
University of California, San Francisco, San Francisco, CA 
Area:
protein structure, mechanism, and inhibitor design
Website:
http://www.sacs.ucsf.edu/home/Ortiz/
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88 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ortiz de Montellano PR. Acetylenes: cytochrome P450 oxidation and mechanism-based enzyme inactivation. Drug Metabolism Reviews. 1-36. PMID 31203694 DOI: 10.1080/03602532.2019.1632891  0.362
2016 Basudhar D, Madrona Y, Yukl ET, Sivaramakrishnan S, Nishida CR, Moënne-Loccoz P, Ortiz de Montellano PR. Distal Hydrogen-Bonding Interactions in Ligand Sensing and Signaling by Mycobacterium tuberculosis DosS. The Journal of Biological Chemistry. PMID 27235395 DOI: 10.1074/Jbc.M116.724815  0.707
2016 Frank DJ, Zhao Y, Wong SH, Basudhar D, De Voss JJ, Ortiz de Montellano PR. Cholesterol Analogs with Degradation-Resistant Alkyl Side-Chains are Effective Mycobacterium tuberculosis Growth Inhibitors. The Journal of Biological Chemistry. PMID 26833565 DOI: 10.1074/Jbc.M115.708172  0.696
2014 Frank DJ, Madrona Y, Ortiz de Montellano PR. Cholesterol ester oxidation by mycobacterial cytochrome P450. The Journal of Biological Chemistry. 289: 30417-25. PMID 25210044 DOI: 10.1074/jbc.M114.602771  0.309
2012 Varfaj F, Lampe JN, Ortiz de Montellano PR. Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy. The Journal of Biological Chemistry. 287: 35181-91. PMID 22923613 DOI: 10.1074/jbc.M112.378042  0.305
2012 Johnston JB, Singh AA, Clary AA, Chen CK, Hayes PY, Chow S, De Voss JJ, Ortiz de Montellano PR. Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1. Bioorganic & Medicinal Chemistry. 20: 4064-81. PMID 22647881 DOI: 10.1016/j.bmc.2012.05.003  0.337
2011 Sivaramakrishnan S, Ouellet H, Du J, McLean KJ, Medzihradszky KF, Dawson JH, Munro AW, Ortiz de Montellano PR. A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acid. Biochemistry. 50: 3014-24. PMID 21381758 DOI: 10.1021/Bi101728Y  0.324
2010 Nishida CR, Lee M, Ortiz De Montellano PR. Efficient hypoxic activation of the anticancer agent AQ4N by CYP2S1 and CYP2W1 Molecular Pharmacology. 78: 497-502. PMID 20566689 DOI: 10.1124/mol.110.065045  0.303
2009 Jiang Y, Sivaramakrishnan S, Hayashi T, Cohen S, Moënne-Loccoz P, Shaik S, Ortiz de Montellano PR. Calculated and experimental spin state of seleno cytochrome P450. Angewandte Chemie (International Ed. in English). 48: 7193-5. PMID 19718734 DOI: 10.1002/Anie.200901485  0.304
2009 Podust LM, Ouellet H, von Kries JP, Ortiz de Montellano PR. Interaction of mycobacterium tuberculosis CYP130 with heterocyclic arylamines Journal of Biological Chemistry. 284: 25211-25219. PMID 19605350 DOI: 10.1074/jbc.M109.017632  0.307
2008 Lampe JN, Floor SN, Gross JD, Nishida CR, Jiang Y, Trnka MJ, Ortiz de Montellano PR. Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. Journal of the American Chemical Society. 130: 16168-9. PMID 18998650 DOI: 10.1021/Ja8071463  0.308
2008 Ortiz de Montellano PR. Mechanism and role of covalent heme binding in the CYP4 family of P450 enzymes and the mammalian peroxidases. Drug Metabolism Reviews. 40: 405-26. PMID 18642140 DOI: 10.1080/03602530802186439  0.324
2008 Kim D, Heo YS, Ortiz de Montellano PR. Efficient catalytic turnover of cytochrome P450(cam) is supported by a T252N mutation. Archives of Biochemistry and Biophysics. 474: 150-6. PMID 18359283 DOI: 10.1016/j.abb.2008.02.044  0.336
2006 Purdy MM, Koo LS, Ortiz De Montellano PR, Klinman JP. Mechanism of O2 activation by cytochrome P450cam studied by isotope effects and transient state kinetics Biochemistry. 45: 15793-15806. PMID 17176102 DOI: 10.1021/Bi061726W  0.732
2006 Verras A, Ortiz de Montellano PR. Protein dynamics and imidazole binding in cytochrome P450 enzymes. Biochemical Society Transactions. 34: 1170-2. PMID 17073778 DOI: 10.1042/Bst0341170  0.721
2006 Verras A, Alian A, Ortiz De Montellano PR. Cytochrome P450 active site plasticity: Attenuation of imidazole binding in cytochrome P450cam by an L244A mutation Protein Engineering, Design and Selection. 19: 491-496. PMID 16943206 DOI: 10.1093/Protein/Gzl035  0.722
2006 Wang J, Evans JP, Ogura H, La Mar GN, Ortiz de Montellano PR. Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network. Biochemistry. 45: 61-73. PMID 16388581 DOI: 10.1021/bi051645k  0.321
2006 Verras A, Kuntz ID, Ortiz de Montellano PR. Chapter 10 Cytochrome P450 Enzymes: Computational Approaches to Substrate Prediction Annual Reports in Computational Chemistry. 2: 171-195. DOI: 10.1016/S1574-1400(06)02010-X  0.7
2005 Ghiladi RA, Medzihradszky KF, Ortiz de Montellano PR. Role of the Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG) as revealed by KatG(M255I). Biochemistry. 44: 15093-105. PMID 16285713 DOI: 10.1021/Bi051463Q  0.611
2005 Ghiladi RA, Medzihradszky KF, Rusnak FM, Ortiz de Montellano PR. Correlation between isoniazid resistance and superoxide reactivity in mycobacterium tuberculosis KatG. Journal of the American Chemical Society. 127: 13428-42. PMID 16173777 DOI: 10.1021/Ja054366T  0.596
2005 Ghiladi RA, Knudsen GM, Medzihradszky KF, Ortiz de Montellano PR. The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties. The Journal of Biological Chemistry. 280: 22651-63. PMID 15840564 DOI: 10.1074/Jbc.M502486200  0.706
2005 Limburg J, LeBrun LA, Ortiz de Montellano PR. The P450cam G248E mutant covalently binds its prosthetic heme group. Biochemistry. 44: 4091-9. PMID 15751986 DOI: 10.1021/bi047686i  0.33
2005 Wang J, Lad L, Poulos TL, Ortiz de Montellano PR. Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant. The Journal of Biological Chemistry. 280: 2797-806. PMID 15525643 DOI: 10.1074/Jbc.M411229200  0.332
2004 Ogura H, Nishida CR, Hoch UR, Perera R, Dawson JH, Ortiz de Montellano PR. EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. Biochemistry. 43: 14712-21. PMID 15544342 DOI: 10.1021/Bi048980D  0.318
2004 Verras A, Kuntz ID, Ortiz de Montellano PR. Computer-assisted design of selective imidazole inhibitors for cytochrome p450 enzymes. Journal of Medicinal Chemistry. 47: 3572-9. PMID 15214784 DOI: 10.1021/Jm030608T  0.701
2004 Koshkin A, Knudsen GM, Ortiz De Montellano PR. Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 427: 41-7. PMID 15178486 DOI: 10.1016/J.Abb.2004.04.017  0.533
2004 Marnett AB, Nomura AM, Shimba N, Ortiz de Montellano PR, Craik CS. Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 101: 6870-5. PMID 15118083 DOI: 10.1073/Pnas.0401613101  0.787
2004 Ghiladi RA, Cabelli DE, Ortiz de Montellano PR. Superoxide reactivity of KatG: insights into isoniazid resistance pathways in TB. Journal of the American Chemical Society. 126: 4772-3. PMID 15080669 DOI: 10.1021/Ja031728T  0.581
2004 Colas C, Ortiz De Montellano PR. Horseradish peroxidase mutants that autocatalytically modify their prosthetic heme group. Insights into mammalian peroxidase heme-protein covalent bonds Journal of Biological Chemistry. 279: 24131-24140. PMID 15039425 DOI: 10.1074/jbc.M401687200  0.315
2004 Purdy MM, Koo LS, Ortiz de Montellano PR, Klinman JP. Steady-state kinetic investigation of cytochrome P450cam: interaction with redox partners and reaction with molecular oxygen. Biochemistry. 43: 271-81. PMID 14705955 DOI: 10.1021/Bi0356045  0.756
2004 Xu F, Falck JR, Ortiz de Montellano PR, Kroetz DL. Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. The Journal of Pharmacology and Experimental Therapeutics. 308: 887-95. PMID 14634044 DOI: 10.1124/Jpet.103.059626  0.449
2003 Li Y, Syvitski RT, Auclair K, Ortiz de Montellano P, La Mar GN. Solution 1H, 15N NMR spectroscopic characterization of substrate-bound, cyanide-inhibited human heme oxygenase: water occupation of the distal cavity. Journal of the American Chemical Society. 125: 13392-403. PMID 14583035 DOI: 10.1021/Ja036176T  0.587
2003 Knudsen GM, Nishida CR, Mooney SD, Ortiz de Montellano PR. Nitric-oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity. The Journal of Biological Chemistry. 278: 31814-24. PMID 12805387 DOI: 10.1074/Jbc.M303267200  0.517
2003 Auclair K, Huang HW, Moënne-Loccoz P, Ortiz de Montellano PR. Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein Expression and Purification. 28: 340-9. PMID 12699699 DOI: 10.1016/S1046-5928(02)00699-X  0.609
2003 Puchkaev AV, Koo LS, Ortiz de Montellano PR. Aromatic stacking as a determinant of the thermal stability of CYP119 from Sulfolobus solfataricus. Archives of Biochemistry and Biophysics. 409: 52-8. PMID 12464244 DOI: 10.1016/S0003-9861(02)00402-2  0.74
2002 Syvitski RT, Li Y, Auclair K, Ortiz De Montellano PR, La Mar GN. 1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1. Journal of the American Chemical Society. 124: 14296-7. PMID 12452690 DOI: 10.1021/Ja028108X  0.591
2002 Nishida CR, Knudsen G, Straub W, Ortiz de Montellano PR. Electron supply and catalytic oxidation of nitrogen by cytochrome P450 and nitric oxide synthase. Drug Metabolism Reviews. 34: 479-501. PMID 12214661 DOI: 10.1081/Dmr-120005648  0.555
2002 Li Y, Syvitski RT, Auclair K, Wilks A, Ortiz De Montellano PR, La Mar GN. Solution NMR characterization of an unusual distal H-bond network in the active site of the cyanide-inhibited, human heme oxygenase complex of the symmetric substrate, 2,4-dimethyldeuterohemin. The Journal of Biological Chemistry. 277: 33018-31. PMID 12070167 DOI: 10.1074/Jbc.M204216200  0.616
2002 Auclair K, Hu Z, Little DM, Ortiz De Montellano PR, Groves JT. Revisiting the mechanism of P450 enzymes with the radical clocks norcarane and spiro[2,5]octane. Journal of the American Chemical Society. 124: 6020-7. PMID 12022835 DOI: 10.1021/Ja025608H  0.627
2002 Hawkes DB, Adams GW, Burlingame AL, Ortiz de Montellano PR, De Voss JJ. Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization. The Journal of Biological Chemistry. 277: 27725-32. PMID 12016226 DOI: 10.1074/jbc.M203382200  0.323
2002 Koo LS, Immoos CE, Cohen MS, Farmer PJ, Ortiz de Montellano PR. Enhanced electron transfer and lauric acid hydroxylation by site-directed mutagenesis of CYP119. Journal of the American Chemical Society. 124: 5684-91. PMID 12010041 DOI: 10.1021/Ja017174G  0.773
2002 LeBrun LA, Xu F, Kroetz DL, Ortiz de Montellano PR. Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family. Biochemistry. 41: 5931-7. PMID 11980497 DOI: 10.1021/Bi025527Y  0.307
2002 LeBrun LA, Hoch U, Ortiz de Montellano PR. Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family. The Journal of Biological Chemistry. 277: 12755-61. PMID 11821421 DOI: 10.1074/jbc.M112155200  0.316
2001 Tschirret-Guth RA, Koo LS, Hoa GH, Ortiz De Montellano PR. Reversible pressure deformation of a thermophilic cytochrome P450 enzyme (CYP119) and its active-site mutants. Journal of the American Chemical Society. 123: 3412-7. PMID 11472111 DOI: 10.1021/ja003947+  0.762
2001 Auclair K, Moënne-Loccoz P, Ortiz de Montellano PR. Roles of the proximal heme thiolate ligand in cytochrome p450(cam). Journal of the American Chemical Society. 123: 4877-85. PMID 11457314 DOI: 10.1021/Ja0040262  0.648
2001 La Mar GN, Asokan A, Espiritu B, Yeh DC, Auclair K, Ortiz De Montellano PR. Solution 1H NMR of the active site of substrate-bound, cyanide-inhibited human heme oxygenase. comparison to the crystal structure of the water-ligated form. The Journal of Biological Chemistry. 276: 15676-87. PMID 11297521 DOI: 10.1074/Jbc.M009974200  0.614
2000 Xiang H, Tschirret-Guth RA, Ortiz De Montellano PR. An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates. The Journal of Biological Chemistry. 275: 35999-6006. PMID 10956654 DOI: 10.1074/jbc.M005811200  0.356
2000 Liu Y, Koenigs Lightning L, Huang H, Moënne-Loccoz P, Schuller DJ, Poulos TL, Loehr TM, Ortiz de Montellano PR. Replacement of the distal glycine 139 transforms human heme oxygenase-1 into a peroxidase. The Journal of Biological Chemistry. 275: 34501-7. PMID 10942763 DOI: 10.1074/Jbc.M004245200  0.339
2000 Hoch U, Falck JR, Ortiz De Montellano PR. Molecular basis for the ω-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases Journal of Biological Chemistry. 275: 26952-26958. PMID 10869363 DOI: 10.1074/Jbc.M004841200  0.446
2000 Yano JK, Koo LS, Schuller DJ, Li H, Ortiz de Montellano PR, Poulos TL. Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus. The Journal of Biological Chemistry. 275: 31086-92. PMID 10859321 DOI: 10.1074/Jbc.M004281200  0.752
2000 Tschirret-Guth RA, Koo LS, Ortiz de Montellano PR. Protein control of the formation and decomposition of the CYP119 and CYP101 aryl-iron complexes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 5: 204-12. PMID 10819465 DOI: 10.1007/S007750050364  0.762
2000 Koo LS, Tschirret-Guth RA, Straub WE, Moënne-Loccoz P, Loehr TM, Ortiz de Montellano PR. The active site of the thermophilic CYP119 from Sulfolobus solfataricus. The Journal of Biological Chemistry. 275: 14112-23. PMID 10799487 DOI: 10.1074/Jbc.275.19.14112  0.757
1999 Rodríguez-Crespo I, Nishida CR, Knudsen GM, Ortiz De Montellano PR. Mutation of the five conserved histidines in the endothelial nitric- oxide synthase hemoprotein domain. No evidence for a non-heme metal requirement for catalysis Journal of Biological Chemistry. 274: 21617-21624. PMID 10419469 DOI: 10.1074/Jbc.274.31.21617  0.537
1998 Dierks EA, Davis SC, Ortiz De Montellano PR. Glu-320 and Asp-323 are determinants of the CYP4A1 hydroxylation regiospecificity and resistance to inactivation by 1-aminobenzotriazole Biochemistry. 37: 1839-1847. PMID 9485309 DOI: 10.1021/bi972458s  0.344
1997 Rutenber EE, De Voss JJ, Hoffman L, Stroud RM, Lee KH, Alvarez J, McPhee F, Craik C, Ortiz De Montellano PR. The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease Bioorganic and Medicinal Chemistry. 5: 1311-1320. PMID 9377091 DOI: 10.1016/S0968-0896(97)00078-3  0.586
1996 Mackman R, Guo Z, Guengerich FP, Ortiz de Montellano PR. Active site topology of human cytochrome P450 2E1. Chemical Research in Toxicology. 9: 223-6. PMID 8924594 DOI: 10.1021/TX950130Z  0.329
1996 Mackman R, Tschirret-Guth RA, Smith G, Hayhurst GP, Ellis SW, Lennard MS, Tucker GT, Wolf CR, Ortiz de Montellano PR. Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants. Archives of Biochemistry and Biophysics. 331: 134-40. PMID 8660692 DOI: 10.1006/ABBI.1996.0291  0.325
1994 Shirane N, Sui Z, Peterson JA, Ortiz de Montellano PR. Cytochrome P450BM-3 (CYP102): regiospecificity of oxidation of omega-unsaturated fatty acids and mechanism-based inactivation. Biochemistry. 32: 13732-41. PMID 8257708 DOI: 10.1021/Bi00212A044  0.306
1994 Zou AP, Imig JD, Ortiz de Montellano PR, Sui Z, Falck JR, Roman RJ. Effect of P-450 omega-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback. The American Journal of Physiology. 266: F934-41. PMID 8023972 DOI: 10.1152/Ajprenal.1994.266.6.F934  0.397
1994 Hiroya K, Murakami Y, Shimizu T, Hatano M, Ortiz de Montellano PR. Differential roles of Glu318 and Thr319 in cytochrome P450 1A2 catalysis supported by NADPH-cytochrome P450 reductase and tert-butyl hydroperoxide. Archives of Biochemistry and Biophysics. 310: 397-401. PMID 7910007 DOI: 10.1006/Abbi.1994.1184  0.302
1993 Chan WK, Sui Z, Ortiz de Montellano PR. Determinants of protein modification versus heme alkylation: inactivation of cytochrome P450 1A1 by 1-ethynylpyrene and phenylacetylene. Chemical Research in Toxicology. 6: 38-45. PMID 8448348 DOI: 10.1021/TX00031A006  0.306
1993 Tuck SF, Hiroya K, Shimizu T, Hatano M, Ortiz de Montellano PR. The cytochrome P450 1A2 active site: topology and perturbations caused by glutamic acid-318 and threonine-319 mutations. Biochemistry. 32: 2548-53. PMID 8095402 DOI: 10.1021/Bi00061A012  0.322
1992 Samokyszyn VM, Ortiz de Montellano PR. Topology of the chloroperoxidase active site: regiospecificity of heme modification by phenylhydrazine and sodium azide. Biochemistry. 30: 11646-53. PMID 1661144 DOI: 10.1021/BI00114A006  0.328
1990 DePillis GD, Ortiz de Montellano PR. Substrate oxidation by the heme edge of fungal peroxidases. Reaction of Coprinus macrorhizus peroxidase with hydrazines and sodium azide. Biochemistry. 28: 7947-52. PMID 2611222 DOI: 10.1021/BI00445A059  0.317
1990 DePillis GD, Wariishi H, Gold MH, Ortiz de Montellano PR. Inactivation of lignin peroxidase by phenylhydrazine and sodium azide. Archives of Biochemistry and Biophysics. 280: 217-23. PMID 2353822 DOI: 10.1016/0003-9861(90)90539-B  0.347
1990 DesJarlais RL, Seibel GL, Kuntz ID, Furth PS, Alvarez JC, Ortiz de Montellano PR, DeCamp DL, Babé LM, Craik CS. Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease. Proceedings of the National Academy of Sciences of the United States of America. 87: 6644-8. PMID 2204060 DOI: 10.1073/Pnas.87.17.6644  0.548
1988 Salaün JP, Simon A, Durst F, Reich NO, Ortiz de Montellano PR. Differential inactivation of plant lauric acid omega- and in-chain-hydroxylases by terminally unsaturated fatty acids. Archives of Biochemistry and Biophysics. 260: 540-5. PMID 3341756 DOI: 10.1016/0003-9861(88)90479-1  0.502
1988 Lukton D, Mackie JE, Lee JS, Marks GS, Ortiz de Montellano PR. 2,2-Dialkyl-1,2-dihydroquinolines: cytochrome P-450 catalyzed N-alkylporphyrin formation, ferrochelatase inhibition, and induction of 5-aminolevulinic acid synthase activity. Chemical Research in Toxicology. 1: 208-15. PMID 2979733 DOI: 10.1021/TX00004A004  0.305
1987 Komives EA, Ortiz de Montellano PR. Mechanism of oxidation of pi bonds by cytochrome P-450. Electronic requirements of the transition state in the turnover of phenylacetylenes. The Journal of Biological Chemistry. 262: 9793-802. PMID 3597438  0.6
1986 Reich NO, Ortiz de Montellano PR. Dissociation of increased lauric acid omega-hydroxylase activity from the antilipidemic action of clofibrate. Biochemical Pharmacology. 35: 1227-33. PMID 3964299 DOI: 10.1016/0006-2952(86)90264-9  0.528
1985 Ortiz de Montellano PR, Komives EA. Branchpoint for heme alkylation and metabolite formation in the oxidation of arylacetylenes by cytochrome P-450. The Journal of Biological Chemistry. 260: 3330-6. PMID 3972828  0.574
1984 Salaun JP, Reichhart D, Simon A, Durst F, Reich NO, Ortiz de Montellano PR. Autocatalytic inactivation of plant cytochrome P-450 enzymes: selective inactivation of the lauric acid in-chain hydroxylase from Helianthus tuberosus L. by unsaturated substrate analogs. Archives of Biochemistry and Biophysics. 232: 1-7. PMID 6742847 DOI: 10.1016/0003-9861(84)90515-0  0.573
1983 Ortiz de Montellano PR, Augusto O, Viola F, Kunze KL. Carbon radicals in the metabolism of alkyl hydrazines. The Journal of Biological Chemistry. 258: 8623-9. PMID 6305994  0.54
1982 Ortiz de Montellano PR, Kunze KL, Cole SP, Marks GS. Differential inhibition of hepatic ferrochelatase by the isomers of N-ethylprotoporphyrin IX. Biochemical and Biophysical Research Communications. 103: 581-6. PMID 7332558 DOI: 10.1016/0006-291X(81)90491-5  0.572
1982 Ortiz de Montellano PR, Kunze KL. Cytochrome P-450 inactivation: structure of the prosthetic heme adduct with propyne. Biochemistry. 20: 7266-71. PMID 7317380 DOI: 10.1021/Bi00528A033  0.661
1982 Ortiz de Montellano PR, Mico BA, Mathews JM, Kunze KL, Miwa GT, Lu AY. Selective inactivation of cytochrome P-450 isozymes by suicide substrates. Archives of Biochemistry and Biophysics. 210: 717-28. PMID 7305355 DOI: 10.1016/0003-9861(81)90239-3  0.615
1982 Augusto O, Kunze KL, Ortiz de Montellano PR. N-Phenylprotoporphyrin IX formation in the hemoglobin-phenylhydrazine reaction. Evidence for a protein-stabilized iron-phenyl intermediate. The Journal of Biological Chemistry. 257: 6231-41. PMID 7076671  0.571
1982 Augusto O, Beilan HS, Ortiz de Montellano PR. The catalytic mechanism of cytochrome P-450. Spin-trapping evidence for one-electron substrate oxidation. The Journal of Biological Chemistry. 257: 11288-95. PMID 6288676  0.59
1982 Ortiz de Montellano PR, Kunze KL, Beilan HS, Wheeler C. Destruction of cytochrome P-450 by vinyl fluoride, fluroxene, and acetylene. Evidence for a radical intermediate in olefin oxidation. Biochemistry. 21: 1331-9. PMID 6122467 DOI: 10.1021/Bi00535A035  0.664
1981 Ortiz de Montellano PR, Kunze KL. Shift of the acetylenic hydrogen during chemical and enzymatic oxidation of the biphenylacetylene triple bond. Archives of Biochemistry and Biophysics. 209: 710-2. PMID 7294821 DOI: 10.1016/0003-9861(81)90333-7  0.582
1981 Ortiz de Montellano PR, Beilan HS, Kunze KL. N-Methylprotoporphyrin IX: chemical synthesis and identification as the green pigment produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine treatment. Proceedings of the National Academy of Sciences of the United States of America. 78: 1490-4. PMID 6940170 DOI: 10.1073/pnas.78.3.1490  0.6
1981 Ortiz de Montellano PR, Kunze KL, Cole SP, Marks GS. Inhibition of hepatic ferrochelatase by the four isomers of N-methylprotoporphyrin IX. Biochemical and Biophysical Research Communications. 97: 1436-42. PMID 6894236 DOI: 10.1016/S0006-291X(80)80026-X  0.574
1981 Augusto O, Ortiz de Montellano PR, Quintanilha A. Spin-trapping of free radicals formed during microsomal metabolism of ethylhydrazine and acetylhydrazine. Biochemical and Biophysical Research Communications. 101: 1324-30. PMID 6272782 DOI: 10.1016/0006-291X(81)91592-8  0.539
1980 Ortiz de Montellano PR, Kunze KL. Inactivation of hepatic cytochrome P-450 by allenic substrates. Biochemical and Biophysical Research Communications. 94: 443-9. PMID 7396909 DOI: 10.1016/0006-291X(80)91251-6  0.63
1979 Farrell GC, Schmid R, Kunze KL, Ortiz de Montellano PR. Exogenous heme restores in vivo functional capacity of hepatic cytochrome P-450 destroyed by allylisopropylacetamide. Biochemical and Biophysical Research Communications. 89: 456-63. PMID 486175 DOI: 10.1016/0006-291X(79)90651-X  0.615
1979 Ortiz De Montellano PR, Kunze KL, Yost GS, Mico BA. Self-catalyzed destruction of cytochrome P-450: Covalent binding of ethynyl sterols to prosthetic heme Proceedings of the National Academy of Sciences of the United States of America. 76: 746-749. PMID 284396 DOI: 10.1073/pnas.76.2.746  0.728
1967 Corey EJ, Ortiz de Montellano PR, Lin K, Dean PD. 2,3-iminosqualene, a potent inhibitor of the enzymic cyclization of 2,3-oxidosqualene to sterols. Journal of the American Chemical Society. 89: 2797-8. PMID 6043808 DOI: 10.1021/Ja00987A089  0.389
1967 Corey EJ, Ortiz de Montellano PR. Enzymic synthesis of beta-amyrin from 2,3-oxidosqualene. Journal of the American Chemical Society. 89: 3362-3. PMID 6042774 DOI: 10.1021/Ja00989A055  0.319
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