Stefan Grathwohl, Ph.D. - Related publications

Affiliations: 
Roche, Indianapolis, IN, United States 
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Read J, Suphioglu C. Identification of a BACE1 Binding Peptide Candidate for the Prevention of Amyloid Beta in Alzheimer's Disease. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 53: 413-428. PMID 31415717 DOI: 10.33594/000000147   
2019 Chen Y, Xu J, Zhou X, Liu S, Zhang Y, Ma S, Fu AKY, Ip NY, Chen Y. Changes of protein phosphorylation are associated with synaptic functions during the early stage of Alzheimer's disease. Acs Chemical Neuroscience. PMID 31424205 DOI: 10.1021/acschemneuro.9b00190   
2019 Grimaldi A, Pediconi N, Oieni F, Pizzarelli R, Rosito M, Giubettini M, Santini T, Limatola C, Ruocco G, Ragozzino D, Di Angelantonio S. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Frontiers in Neuroscience. 13: 925. PMID 31551688 DOI: 10.3389/fnins.2019.00925   
2019 Mputhia Z, Hone E, Tripathi T, Sargeant T, Martins R, Bharadwaj P. Autophagy Modulation as a Treatment of Amyloid Diseases. Molecules (Basel, Switzerland). 24. PMID 31527516 DOI: 10.3390/molecules24183372   
2019 Bernabeu-Zornoza A, Coronel R, Palmer C, Monteagudo M, Zambrano A, Liste I. Physiological and pathological effects of amyloid-β species in neural stem cell biology. Neural Regeneration Research. 14: 2035-2042. PMID 31397330 DOI: 10.4103/1673-5374.262571   
2019 Xie Y, Niu M, Ji C, Huang TY, Zhang C, Tian Y, Shi Z, Wang C, Zhao Y, Luo H, Can D, Xu H, Zhang YW, Zhang X. SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse. Frontiers in Cellular Neuroscience. 13: 410. PMID 31551717 DOI: 10.3389/fncel.2019.00410   
2019 Dupont G, Iwanaga J, Yilmaz E, Tubbs RS. Connections Between Amyloid Beta and the Meningeal Lymphatics As a Possible Route for Clearance and Therapeutics. Lymphatic Research and Biology. PMID 31433264 DOI: 10.1089/lrb.2018.0079   
2019 Cheng CH, Lin KJ, Hong CT, Wu D, Chang HM, Liu CH, Hsiao IT, Yang CP, Liu YC, Hu CJ. Plasmon-Activated Water Reduces Amyloid Burden and Improves Memory in Animals with Alzheimer's Disease. Scientific Reports. 9: 13252. PMID 31520077 DOI: 10.1038/s41598-019-49731-8   
2019 Caleb AA, Akiyama T, Kimura A, Kimura Y, Takahashi-Jitsuki A, Nakamura H, Makihara H, Masukawa D, Nakabayashi J, Hirano H, Nakamura F, Saito T, Saido T, Goshima Y. Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease. Neurobiology of Disease. 104603. PMID 31494281 DOI: 10.1016/j.nbd.2019.104603   
2019 Wu T, Dejanovic B, Gandham VD, Gogineni A, Edmonds R, Schauer S, Srinivasan K, Huntley MA, Wang Y, Wang TM, Hedehus M, Barck KH, Stark M, Ngu H, Foreman O, et al. Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy. Cell Reports. 28: 2111-2123.e6. PMID 31433986 DOI: 10.1016/j.celrep.2019.07.060   
2019 Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M. Alzheimer's disease: pathogenesis, diagnostics, and therapeutics. International Journal of Nanomedicine. 14: 5541-5554. PMID 31410002 DOI: 10.2147/IJN.S200490   
2019 Fan W, Sun Y, Shi Z, Wang H, Deng J. Mouse Induced Pluripotent Stem Cells-Derived Alzheimer's Disease Cerebral Organoid Culture and Neural Differentiation Disorders. Neuroscience Letters. 134433. PMID 31421155 DOI: 10.1016/j.neulet.2019.134433   
2019 Tian X, Xie B, Zou Z, Jiao Y, Lin LE, Chen CL, Hsu CC, Peng J, Yang Z. Multimodal Imaging of Amyloid Plaques: Fusion of the Single-probe Mass Spectrometry Image and Fluorescence Microscopy Image. Analytical Chemistry. PMID 31536324 DOI: 10.1021/acs.analchem.9b02792   
2019 Zhang Y, Zhao Y, Zhang L, Yu W, Wang Y, Chang W. Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer's Disease. Frontiers in Cellular Neuroscience. 13: 339. PMID 31417361 DOI: 10.3389/fncel.2019.00339   
2019 Verkhratsky A, Parpura V, Rodriguez-Arellano JJ, Zorec R. Astroglia in Alzheimer's Disease. Advances in Experimental Medicine and Biology. 1175: 273-324. PMID 31583592 DOI: 10.1007/978-981-13-9913-8_11   
2019 Chen Y, Li M, Zheng Y, Yang L. Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice. Journal of Visualized Experiments : Jove. PMID 31424430 DOI: 10.3791/59310   
2019 Polis B, Gurevich V, Assa M, Samson AO. Norvaline Restores the BBB Integrity in a Mouse Model of Alzheimer's Disease. International Journal of Molecular Sciences. 20. PMID 31540372 DOI: 10.3390/ijms20184616   
2019 Pietronigro E, Zenaro E, Bianca VD, Dusi S, Terrabuio E, Iannoto G, Slanzi A, Ghasemi S, Nagarajan R, Piacentino G, Tosadori G, Rossi B, Constantin G. Blockade of α4 integrins reduces leukocyte-endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer's disease. Scientific Reports. 9: 12055. PMID 31427644 DOI: 10.1038/s41598-019-48538-x   
2019 Gomes LA, Hipp SA, Rijal Upadhaya A, Balakrishnan K, Ospitalieri S, Koper MJ, Largo-Barrientos P, Uytterhoeven V, Reichwald J, Rabe S, Vandenberghe R, von Arnim CAF, Tousseyn T, Feederle R, Giudici C, et al. Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein. Acta Neuropathologica. PMID 31414210 DOI: 10.1007/s00401-019-02053-5   
2019 Liu J, Li L. Targeting Autophagy for the Treatment of Alzheimer's Disease: Challenges and Opportunities. Frontiers in Molecular Neuroscience. 12: 203. PMID 31507373 DOI: 10.3389/fnmol.2019.00203   
2019 Stefanovski L, Triebkorn P, Spiegler A, Diaz-Cortes MA, Solodkin A, Jirsa V, McIntosh AR, Ritter P, . Linking Molecular Pathways and Large-Scale Computational Modeling to Assess Candidate Disease Mechanisms and Pharmacodynamics in Alzheimer's Disease. Frontiers in Computational Neuroscience. 13: 54. PMID 31456676 DOI: 10.3389/fncom.2019.00054   
2019 Hashimoto M, Yamazaki A, Ohno A, Kimura T, Winblad B, Tjernberg LO. A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 31524172 DOI: 10.3233/JAD-190700   
2019 Karakatsani ME, Kugelman T, Ji R, Murillo M, Wang S, Niimi Y, Small SA, Duff KE, Konofagou EE. Unilateral Focused Ultrasound-Induced Blood-Brain Barrier Opening Reduces Phosphorylated Tau from The rTg4510 Mouse Model. Theranostics. 9: 5396-5411. PMID 31410223 DOI: 10.7150/thno.28717   
2019 Toriu N, Sawa N, Hiramatsu R, Mizuno H, Ikuma D, Sekine A, Hayami N, Sumida K, Yamanouchi M, Hasegawa E, Hoshino J, Takaichi K, Wake A, Ohashi K, Fujii T, et al. Regression of renal amyloid deposits by VAD therapy plus autologous stem cell transplantation in a patient with primary AL amyloidosis. Cen Case Reports. PMID 31522370 DOI: 10.1007/s13730-019-00416-1   
2019 Chernova TA, Chernoff YO, Wilkinson KD. Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery. Molecules (Basel, Switzerland). 24. PMID 31540362 DOI: 10.3390/molecules24183388   
2019 Sun H, Liu M, Sun T, Chen Y, Lan Z, Lian B, Zhao C, Liu Z, Zhang J, Liu Y. Age-related changes in hippocampal AD pathology, actin remodeling proteins and spatial memory behavior of male APP/PS1 mice. Behavioural Brain Research. 112182. PMID 31472195 DOI: 10.1016/j.bbr.2019.112182   
2019 Chatterjee P, Elmi M, Goozee K, Shah T, Sohrabi HR, Dias CB, Pedrini S, Shen K, Asih PR, Dave P, Taddei K, Vanderstichele H, Zetterberg H, Blennow K, Martins RN. Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 31424403 DOI: 10.3233/JAD-190533   
2019 Xicota L, Ichou F, Lejeune FX, Colsch B, Tenenhaus A, Leroy I, Fontaine G, Lhomme M, Bertin H, Habert MO, Epelbaum S, Dubois B, Mochel F, Potier MC, . Multi-omics signature of brain amyloid deposition in asymptomatic individuals at-risk for Alzheimer's disease: The INSIGHT-preAD study. Ebiomedicine. PMID 31492558 DOI: 10.1016/j.ebiom.2019.08.051   
2019 Chaudhuri P, Prajapati KP, Anand BG, Dubey K, Kar K. Amyloid cross-seeding raises new dimensions to understanding of amyloidogenesis mechanism. Ageing Research Reviews. 100937. PMID 31430565 DOI: 10.1016/j.arr.2019.100937   
2019 Yanagawa T, Takao M, Yasuda M, Kamide T, Sato H, Suzuki K, Ikeda T, Kikkawa Y, Kurita H. Clinical and neuropathologic analysis of intracerebral hemorrhage in patients with cerebral amyloid angiopathy. Clinical Neurology and Neurosurgery. 176: 110-115. PMID 30554091 DOI: 10.1016/j.clineuro.2018.11.020   
2019 Giorgi FS, Saccaro LF, Galgani A, Busceti CL, Biagioni F, Frati A, Fornai F. The role of Locus Coeruleus in neuroinflammation occurring in Alzheimer's disease. Brain Research Bulletin. 153: 47-58. PMID 31419539 DOI: 10.1016/j.brainresbull.2019.08.007   
2019 Xu M, Li R, Li X, Lv G, Li S, Sun A, Zhou Y, Yi T. NIR fluorescent probes with good water-solubility for detection of amyloid beta aggregates in Alzheimer's disease. Journal of Materials Chemistry. B. PMID 31451829 DOI: 10.1039/c9tb01012b   
2019 Singh-Bains MK, Linke V, Austria MDR, Tan AYS, Scotter EL, Mehrabi NF, Faull RLM, Dragunow M. Altered microglia and neurovasculature in the Alzheimer's disease cerebellum. Neurobiology of Disease. 104589. PMID 31454549 DOI: 10.1016/j.nbd.2019.104589   
2019 Tian ZY, Wang CY, Wang T, Li YC, Wang ZY. Glial S100A6 Degrades β-amyloid Aggregation through Targeting Competition with Zinc Ions. Aging and Disease. 10: 756-769. PMID 31440382 DOI: 10.14336/AD.2018.0912   
2019 Matsuda H, Shigemoto Y, Sato N. Neuroimaging of Alzheimer's disease: focus on amyloid and tau PET. Japanese Journal of Radiology. PMID 31493197 DOI: 10.1007/s11604-019-00867-7   
2019 Hemonnot AL, Hua J, Ulmann L, Hirbec H. Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities. Frontiers in Aging Neuroscience. 11: 233. PMID 31543810 DOI: 10.3389/fnagi.2019.00233   
2019 Hemonnot AL, Hua J, Ulmann L, Hirbec H. Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities. Frontiers in Aging Neuroscience. 11: 233. PMID 31543810 DOI: 10.3389/fnagi.2019.00233   
2019 Spangenberg E, Severson PL, Hohsfield LA, Crapser J, Zhang J, Burton EA, Zhang Y, Spevak W, Lin J, Phan NY, Habets G, Rymar A, Tsang G, Walters J, Nespi M, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nature Communications. 10: 3758. PMID 31434879 DOI: 10.1038/s41467-019-11674-z   
2019 Liang ZM, Peng YH, Chen Y, Long LL, Luo HJ, Chen YJ, Liang YL, Tian YH, Li SJ, Shi YS, Zhang XM. The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-β Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease. Nucleic Acid Therapeutics. PMID 31513457 DOI: 10.1089/nat.2019.0812   
2019 Nam Y, Joo B, Lee JY, Han KM, Ryu KY, Koh YH, Kim J, Koo JW, We YM, Hoe HS. ALWPs Improve Cognitive Function and Regulate Aβ Plaque and Tau Hyperphosphorylation in a Mouse Model of Alzheimer's Disease. Frontiers in Molecular Neuroscience. 12: 192. PMID 31474828 DOI: 10.3389/fnmol.2019.00192   
2019 Gary C, Lam S, Hérard AS, Koch JE, Petit F, Gipchtein P, Sawiak SJ, Caillierez R, Eddarkaoui S, Colin M, Aujard F, Deslys JP, , Brouillet E, Buée L, et al. Encephalopathy induced by Alzheimer brain inoculation in a non-human primate. Acta Neuropathologica Communications. 7: 126. PMID 31481130 DOI: 10.1186/s40478-019-0771-x   
2019 Wang H, Shen Y, Chuang H, Chiu C, Ye Y, Zhao L. Neuroinflammation in Alzheimer's Disease: Microglia, Molecular Participants and Therapeutic Choices. Current Alzheimer Research. 16: 659-674. PMID 31580243 DOI: 10.2174/1567205016666190503151648   
2019 Boche D, Gerhard A, Rodriguez-Vieitez E, . Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging. PMID 31396666 DOI: 10.1007/s00259-019-04462-w   
2019 Chen X, Xu B, Nie L, He K, Zhou L, Huang X, Spencer P, Yang X, Liu J. Flavanol-rich lychee fruit extract substantially reduces progressive cognitive and molecular deficits in a triple-transgenic animal model of Alzheimer disease. Nutritional Neuroscience. 1-15. PMID 31603034 DOI: 10.1080/1028415X.2019.1673527   
2019 Avni A, Swasthi HM, Majumdar A, Mukhopadhyay S. Intrinsically disordered proteins in the formation of functional amyloids from bacteria to humans. Progress in Molecular Biology and Translational Science. 166: 109-143. PMID 31521230 DOI: 10.1016/bs.pmbts.2019.05.005   
2019 Lana E, Gellerbring A, Jung S, Nordberg A, Unger Lithner C, Darreh-Shori T. Homomeric and Heteromeric Aβ Species Exist in Human Brain and CSF Regardless of Alzheimer's Disease Status and Risk Genotype. Frontiers in Molecular Neuroscience. 12: 176. PMID 31417354 DOI: 10.3389/fnmol.2019.00176   
2019 Velazquez R, Ferreira E, Knowles S, Fux C, Rodin A, Winslow W, Oddo S. Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation. Aging Cell. e13037. PMID 31560162 DOI: 10.1111/acel.13037   
2019 Chandra A, Valkimadi PE, Pagano G, Cousins O, Dervenoulas G, Politis M, . Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment. Human Brain Mapping. PMID 31520513 DOI: 10.1002/hbm.24782   
2019 Long JM, Holtzman DM. Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. Cell. 179: 312-339. PMID 31564456 DOI: 10.1016/j.cell.2019.09.001   
2019 Kisby B, Jarrell JT, Agar ME, Cohen DS, Rosin ER, Cahill CM, Rogers JT, Huang X. Alzheimer's Disease and Its Potential Alternative Therapeutics. Journal of Alzheimer's Disease & Parkinsonism. 9. PMID 31588368 DOI: 10.4172/2161-0460.1000477