| Year |
Citation |
Score |
| 2023 |
Hernandez CC, Hu N, Shen W, Macdonald RL. Epileptic Encephalopathy Structural Variants Share Common Gating and Trafficking Defects. Biomolecules. 13. PMID 38136660 DOI: 10.3390/biom13121790 |
0.433 |
|
| 2023 |
Hernandez CC, Shen Y, Hu N, Shen W, Narayanan V, Ramsey K, He W, Zou L, Macdonald RL. Variants Associated with Febrile Seizures. Biomolecules. 13. PMID 36979350 DOI: 10.3390/biom13030414 |
0.324 |
|
| 2023 |
Hernandez CC, Gimenez LE, Dahir NS, Peisley A, Cone RD. The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: A novel player in energy homeostasis control. American Journal of Physiology. Cell Physiology. PMID 36717105 DOI: 10.1152/ajpcell.00335.2022 |
0.387 |
|
| 2022 |
Hernandez CC, Tarfa RA, Miguel I Limcaoco J, Liu R, Mondal P, Hill C, Keith Duncan R, Tzounopoulos T, Stephenson CRJ, O'Meara MJ, Wipf P. Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype. Bioorganic & Medicinal Chemistry Letters. 71: 128841. PMID 35671848 DOI: 10.1016/j.bmcl.2022.128841 |
0.377 |
|
| 2021 |
Hernandez CC, Tian X, Hu N, Shen W, Catron MA, Yang Y, Chen J, Jiang Y, Zhang Y, Macdonald RL. Dravet syndrome-associated mutations in , and define the genetic landscape of defects of GABA receptors. Brain Communications. 3: fcab033. PMID 34095830 DOI: 10.1093/braincomms/fcab033 |
0.312 |
|
| 2020 |
Chen V, Bruno AE, Britt LL, Hernandez CC, Gimenez LE, Peisley A, Cone RD, Millhauser GL. Membrane Orientation and Oligomerization of the Melanocortin Receptor Accessory Protein 2. The Journal of Biological Chemistry. PMID 32943551 DOI: 10.1074/Jbc.Ra120.015482 |
0.324 |
|
| 2020 |
Yu J, Gimenez LE, Hernandez CC, Wu Y, Wein AH, Han GW, McClary K, Mittal SR, Burdsall K, Stauch B, Wu L, Stevens SN, Peisley A, Williams SY, Chen V, et al. Determination of the melanocortin-4 receptor structure identifies Ca as a cofactor for ligand binding. Science (New York, N.Y.). 368: 428-433. PMID 32327598 DOI: 10.1126/Science.Aaz8995 |
0.376 |
|
| 2020 |
Rouault AAJ, Rosselli-Murai LK, Hernandez CC, Gimenez LE, Tall GG, Sebag JA. The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a. Science Signaling. 13. PMID 31911434 DOI: 10.1126/Scisignal.Aax4569 |
0.305 |
|
| 2019 |
Hernandez CC, XiangWei W, Hu N, Shen D, Shen W, Lagrange AH, Zhang Y, Dai L, Ding C, Sun Z, Hu J, Zhu H, Jiang Y, Macdonald RL. Altered inhibitory synapses in de novo GABRA5 and GABRA1 mutations associated with early onset epileptic encephalopathies. Brain : a Journal of Neurology. PMID 31056671 DOI: 10.1093/Brain/Awz123 |
0.454 |
|
| 2019 |
Hernandez CC, Macdonald RL. A Structural Look at GABA Receptor Mutations Linked to Epilepsy Syndromes. Brain Research. PMID 30851244 DOI: 10.1016/J.Brainres.2019.03.004 |
0.445 |
|
| 2018 |
Choveau FS, De la Rosa V, Bierbower SM, Hernandez CC, Shapiro MS. Phosphatidylinositol 4,5-bisphosphate (PIP2) regulates KCNQ3 K+ channels by interacting with four cytoplasmic channel domains. The Journal of Biological Chemistry. PMID 30348901 DOI: 10.1074/Jbc.Ra118.005401 |
0.452 |
|
| 2018 |
Carrington S, Hernandez C, Swale D, Aluko OA, Denton JS, Cone R. G protein-coupled receptors differentially regulate glycosylation and activity of the inwardly rectifying potassium channel Kir7.1. The Journal of Biological Chemistry. PMID 30257863 DOI: 10.1074/Jbc.Ra118.003238 |
0.478 |
|
| 2018 |
Wang CH, Hernandez CC, Wu J, Zhou N, Hsu HY, Shen ML, Wang YC, Macdonald RL, Wu DC. A missense mutation A384P associated with human hyperekplexia reveals a desensitization site of glycine receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29440552 DOI: 10.1523/Jneurosci.0674-16.2018 |
0.485 |
|
| 2017 |
Hernandez CC, Zhang Y, Hu N, Shen D, Shen W, Liu X, Kong W, Jiang Y, Macdonald RL. GABA A Receptor Coupling Junction and Pore GABRB3 Mutations are Linked to Early-Onset Epileptic Encephalopathy. Scientific Reports. 7: 15903. PMID 29162865 DOI: 10.1038/S41598-017-16010-3 |
0.543 |
|
| 2017 |
Hernandez CC, Kong W, Hu N, Zhang Y, Shen W, Jackson L, Liu X, Jiang Y, Macdonald RL. Altered Channel Conductance States and Gating of GABAA Receptors by a Pore Mutation Linked to Dravet Syndrome. Eneuro. 4. PMID 28197552 DOI: 10.1523/ENEURO.0251-16.2017 |
0.502 |
|
| 2016 |
Shen D, Hernandez CC, Shen W, Hu N, Poduri A, Shiedley B, Rotenberg A, Datta AN, Leiz S, Patzer S, Boor R, Ramsey K, Goldberg E, Helbig I, Ortiz-Gonzalez XR, et al. De novo GABRG2 mutations associated with epileptic encephalopathies. Brain : a Journal of Neurology. PMID 27864268 DOI: 10.1093/Brain/Aww272 |
0.496 |
|
| 2016 |
Ishii A, Kang JQ, Schornak CC, Hernandez CC, Shen W, Watkins JC, Macdonald RL, Hirose S. A de novo missense mutation of GABRB2 causes early myoclonic encephalopathy. Journal of Medical Genetics. PMID 27789573 DOI: 10.1136/Jmedgenet-2016-104083 |
0.381 |
|
| 2016 |
Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL. Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population. Plos One. 11: e0162883. PMID 27622563 DOI: 10.1371/Journal.Pone.0162883 |
0.472 |
|
| 2016 |
Janve VS, Hernandez CC, Verdier KM, Hu N, Macdonald RL. Epileptic encephalopathy de novo GABRB mutations impair GABAA receptor function. Annals of Neurology. PMID 26950270 DOI: 10.1002/Ana.24631 |
0.456 |
|
| 2014 |
Huang X, Hernandez CC, Hu N, Macdonald RL. Three epilepsy-associated GABRG2 missense mutations at the γ+/β- interface disrupt GABAA receptor assembly and trafficking by similar mechanisms but to different extents. Neurobiology of Disease. 68: 167-79. PMID 24798517 DOI: 10.1016/J.Nbd.2014.04.015 |
0.487 |
|
| 2014 |
Lo WY, Lagrange AH, Hernandez CC, Gurba KN, Macdonald RL. Co-expression of γ2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor β2 subunits. Neurochemical Research. 39: 1088-103. PMID 24213971 DOI: 10.1007/S11064-013-1187-9 |
0.479 |
|
| 2013 |
Tian M, Mei D, Freri E, Hernandez CC, Granata T, Shen W, Macdonald RL, Guerrini R. Impaired surface αβγ GABA(A) receptor expression in familial epilepsy due to a GABRG2 frameshift mutation. Neurobiology of Disease. 50: 135-41. PMID 23069679 DOI: 10.1016/J.Nbd.2012.10.008 |
0.487 |
|
| 2013 |
Hernandez CC, Gurba KN, Hu N, Macdonald RL. GAbAA Receptor Subunit Rare Variants Identified in Patients with Idiopathic Generalized Epilepsy Alter Receptor Gating and Assembly Biophysical Journal. 104: 275a. DOI: 10.1016/J.Bpj.2012.11.1541 |
0.514 |
|
| 2012 |
Huang X, Tian M, Hernandez CC, Hu N, Macdonald RL. The GABRG2 nonsense mutation, Q40X, associated with Dravet syndrome activated NMD and generated a truncated subunit that was partially rescued by aminoglycoside-induced stop codon read-through. Neurobiology of Disease. 48: 115-23. PMID 22750526 DOI: 10.1016/J.Nbd.2012.06.013 |
0.454 |
|
| 2012 |
Choveau FS, Hernandez CC, Bierbower SM, Shapiro MS. Pore determinants of KCNQ3 K+ current expression. Biophysical Journal. 102: 2489-98. PMID 22713564 DOI: 10.1016/J.Bpj.2012.04.018 |
0.468 |
|
| 2012 |
Gurba KN, Hernandez CC, Hu N, Macdonald RL. GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating. The Journal of Biological Chemistry. 287: 12083-97. PMID 22303015 DOI: 10.1074/Jbc.M111.332528 |
0.531 |
|
| 2012 |
Hernandez CC, Gurba KN, Hu N, Macdonald RL. Mapping GABAA Receptor Single Nucleotide Polymorphisms (SNPs) Linked to Epilepsy: Insights into the Receptor Gating and Assembly Biophysical Journal. 102: 111a. DOI: 10.1016/J.Bpj.2011.11.624 |
0.502 |
|
| 2011 |
Hernandez CC, Gurba KN, Hu N, Macdonald RL. The GABRA6 mutation, R46W, associated with childhood absence epilepsy, alters 6β22 and 6β2 GABA(A) receptor channel gating and expression. The Journal of Physiology. 589: 5857-78. PMID 21930603 DOI: 10.1113/Jphysiol.2011.218883 |
0.529 |
|
| 2011 |
Hernandez CC, Gurba KN, Hu N, Macdonald RL. A novel Polymorphism Linked to Epilepsy Encoding a Missense Mutation in the Pre-M1 Region of a6 Subunits Alters the Gating, but not Trafficking, of GABAa Receptors Biophysical Journal. 100: 271a-272a. DOI: 10.1016/J.Bpj.2010.12.1692 |
0.555 |
|
| 2010 |
Lo WY, Lagrange AH, Hernandez CC, Harrison R, Dell A, Haslam SM, Sheehan JH, Macdonald RL. Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating. The Journal of Biological Chemistry. 285: 31348-61. PMID 20639197 DOI: 10.1074/Jbc.M110.151449 |
0.514 |
|
| 2010 |
Bal M, Zhang J, Hernandez CC, Zaika O, Shapiro MS. Ca2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2311-23. PMID 20147557 DOI: 10.1523/Jneurosci.5175-09.2010 |
0.493 |
|
| 2010 |
Tang X, Hernandez CC, Macdonald RL. Modulation of spontaneous and GABA-evoked tonic alpha4beta3delta and alpha4beta3gamma2L GABAA receptor currents by protein kinase A. Journal of Neurophysiology. 103: 1007-19. PMID 19939957 DOI: 10.1152/Jn.00801.2009 |
0.355 |
|
| 2009 |
Hernandez CC, Falkenburger B, Shapiro MS. Affinity for phosphatidylinositol 4,5-bisphosphate determines muscarinic agonist sensitivity of Kv7 K+ channels. The Journal of General Physiology. 134: 437-48. PMID 19858360 DOI: 10.1085/Jgp.200910313 |
0.402 |
|
| 2009 |
Hernandez CC, Shapiro MS. Divergent PIP2 Sensitivity Confers Differential Muscarinic Agonist Efficacy For Suppression Of Kv7 K+ Channels Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.807 |
0.482 |
|
| 2009 |
Bal M, Zhang J, Hernandez CC, Zaika O, Shapiro MS. Disruption Of Interactions Between AKAP79/150 And KCNQ K+ Channels By Ca2+/Calmodulin Observed Using TIRF/FRET Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.3677 |
0.479 |
|
| 2009 |
Zaika O, Bal M, Zhang J, Hernandez CC, Shapiro MS. S17.2 Receptor-specific modulation of K+ and Ca2+ channels of rat sympathetic ganglia by phosphoinositide signals Autonomic Neuroscience: Basic and Clinical. 149: 55. DOI: 10.1016/J.Autneu.2009.05.087 |
0.383 |
|
| 2008 |
Zaika O, Hernandez CC, Bal M, Tolstykh GP, Shapiro MS. Determinants within the turret and pore-loop domains of KCNQ3 K+ channels governing functional activity. Biophysical Journal. 95: 5121-37. PMID 18790849 DOI: 10.1529/Biophysj.108.137604 |
0.493 |
|
| 2008 |
Bal M, Zhang J, Zaika O, Hernandez CC, Shapiro MS. Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis. The Journal of Biological Chemistry. 283: 30668-76. PMID 18786918 DOI: 10.1074/Jbc.M805216200 |
0.442 |
|
| 2008 |
Hernandez CC, Zaika O, Shapiro MS. A carboxy-terminal inter-helix linker as the site of phosphatidylinositol 4,5-bisphosphate action on Kv7 (M-type) K+ channels. The Journal of General Physiology. 132: 361-81. PMID 18725531 DOI: 10.1085/Jgp.200810007 |
0.445 |
|
| 2008 |
Hernandez CC, Nascimento JH, Chaves EA, Costa PC, Masuda MO, Kurtenbach E, Campos DE Carvalho AC, Gimenez LE. Autoantibodies enhance agonist action and binding to cardiac muscarinic receptors in chronic Chagas' disease. Journal of Receptor and Signal Transduction Research. 28: 375-401. PMID 18702010 DOI: 10.1080/10799890802262319 |
0.329 |
|
| 2008 |
Miceli F, Soldovieri MV, Hernandez CC, Shapiro MS, Annunziato L, Taglialatela M. Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunit. Biophysical Journal. 95: 2254-64. PMID 18515377 DOI: 10.1529/Biophysj.107.128371 |
0.462 |
|
| 2008 |
Hernandez CC, Zaika O, Tolstykh GP, Shapiro MS. Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications. The Journal of Physiology. 586: 1811-21. PMID 18238808 DOI: 10.1113/Jphysiol.2007.148304 |
0.472 |
|
| 2007 |
Soldovieri MV, Cilio MR, Miceli F, Bellini G, Miraglia del Giudice E, Castaldo P, Hernandez CC, Shapiro MS, Pascotto A, Annunziato L, Taglialatela M. Atypical gating of M-type potassium channels conferred by mutations in uncharged residues in the S4 region of KCNQ2 causing benign familial neonatal convulsions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4919-28. PMID 17475800 DOI: 10.1523/Jneurosci.0580-07.2007 |
0.518 |
|
| 2006 |
Gamper N, Zaika O, Li Y, Martin P, Hernandez CC, Perez MR, Wang AY, Jaffe DB, Shapiro MS. Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing. The Embo Journal. 25: 4996-5004. PMID 17024175 DOI: 10.1038/Sj.Emboj.7601374 |
0.368 |
|
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