| Year |
Citation |
Score |
| 2024 |
Khoa LTP, Yang W, Shan M, Zhang L, Mao F, Zhou B, Li Q, Malcore R, Harris C, Zhao L, Rao R, Iwase S, Kalantry S, Bielas SL, Lyssiotis CA, et al. Quiescence enables unrestricted cell fate in naive embryonic stem cells. Nature Communications. 15: 1721. PMID 38409226 DOI: 10.1038/s41467-024-46121-1 |
0.336 |
|
| 2024 |
Chen B, Lynn-Nguyen TM, Jadhav P, Halligan BS, Rossiter NJ, Guerra RM, Koshkin S, Koo I, Morlacchi P, Hanna DA, Lin J, Banerjee R, Pagliarini DJ, Patterson AD, Mosalaganti S, ... ... Lyssiotis CA, et al. BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III. Biorxiv : the Preprint Server For Biology. PMID 38352460 DOI: 10.1101/2024.02.02.578646 |
0.303 |
|
| 2023 |
Radyk MD, Nelson BS, Halbrook CJ, Wood A, Lavoie B, Salvatore L, Corfas G, Colacino JA, Shah YM, Crawford HC, Lyssiotis CA. Glucose-6-phosphate dehydrogenase deficiency accelerates pancreatic acinar-to-ductal metaplasia. Biorxiv : the Preprint Server For Biology. PMID 37986898 DOI: 10.1101/2023.11.06.565895 |
0.848 |
|
| 2023 |
Sharma M, Barravecchia I, Magnuson B, Ferris SF, Apfelbaum A, Mbah NE, Cruz J, Krishnamoorthy V, Teis R, Kauss M, Koschmann C, Lyssiotis CA, Ljungman M, Galban S. Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma. Neoplasia (New York, N.Y.). 44: 100931. PMID 37647805 DOI: 10.1016/j.neo.2023.100931 |
0.315 |
|
| 2023 |
Kerk SA, Garcia-Bermudez J, Birsoy K, Sherman MH, Shah YM, Lyssiotis CA. Spotlight on GOT2 in Cancer Metabolism. Oncotargets and Therapy. 16: 695-702. PMID 37635751 DOI: 10.2147/OTT.S382161 |
0.391 |
|
| 2023 |
Liu Z, Villareal L, Goodla L, Kim H, Falcon DM, Haneef M, Martin DR, Zhang L, Lee HJ, Kremer D, Lyssiotis CA, Shah YM, Lin HC, Lin HK, Xue X. Iron promotes glycolysis to drive colon tumorigenesis. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 166846. PMID 37579983 DOI: 10.1016/j.bbadis.2023.166846 |
0.742 |
|
| 2023 |
Apiz Saab JJ, Dzierozynski LN, Jonker PB, AminiTabrizi R, Shah H, Menjivar RE, Scott AJ, Nwosu ZC, Zhu Z, Chen RN, Oh M, Sheehan C, Wahl DR, Pasca di Magliano M, Lyssiotis CA, et al. Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis. Elife. 12. PMID 37254839 DOI: 10.7554/eLife.81289 |
0.397 |
|
| 2023 |
Nwosu ZC, Ward MH, Sajjakulnukit P, Poudel P, Ragulan C, Kasperek S, Radyk M, Sutton D, Menjivar RE, Andren A, Apiz-Saab JJ, Tolstyka Z, Brown K, Lee HJ, Dzierozynski LN, ... ... Lyssiotis CA, et al. Uridine-derived ribose fuels glucose-restricted pancreatic cancer. Nature. PMID 37198494 DOI: 10.1038/s41586-023-06073-w |
0.83 |
|
| 2023 |
Watson DC, Bayik D, Storevik S, Moreino SS, Sprowls SA, Han J, Augustsson MT, Lauko A, Sravya P, Røsland GV, Troike K, Tronstad KJ, Wang S, Sarnow K, Kay K, ... ... Lyssiotis CA, et al. GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. Nature Cancer. PMID 37169842 DOI: 10.1038/s43018-023-00556-5 |
0.3 |
|
| 2023 |
Halbrook CJ, Lyssiotis CA, Pasca di Magliano M, Maitra A. Pancreatic cancer: Advances and challenges. Cell. 186: 1729-1754. PMID 37059070 DOI: 10.1016/j.cell.2023.02.014 |
0.72 |
|
| 2023 |
Maurer HC, Curiel-Garcia A, Holmstrom S, Laise P, Palermo CF, Sastra SA, Andren A, Li Z, LeLarge T, Sagalovskiy I, Ross DR, Rosario V, Lu K, Ferraiuolo E, Spinosa N, ... ... Lyssiotis C, et al. Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer. Biorxiv : the Preprint Server For Biology. PMID 36993718 DOI: 10.1101/2023.03.19.533333 |
0.638 |
|
| 2023 |
Menjivar RE, Nwosu ZC, Du W, Donahue KL, Hong HS, Espinoza C, Brown K, Velez-Delgado A, Yan W, Lima F, Bischoff A, Kadiyala P, Salas-Escabillas D, Crawford HC, Bednar F, ... ... Lyssiotis CA, et al. Arginase 1 is a key driver of immune suppression in pancreatic cancer. Elife. 12. PMID 36727849 DOI: 10.7554/eLife.80721 |
0.736 |
|
| 2022 |
Bell HN, Huber AK, Singhal R, Korimerla N, Rebernick RJ, Kumar R, El-Derany MO, Sajjakulnukit P, Das NK, Kerk SA, Solanki S, James JG, Kim D, Zhang L, Chen B, ... ... Lyssiotis CA, et al. Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer. Cell Metabolism. PMID 36528023 DOI: 10.1016/j.cmet.2022.11.013 |
0.347 |
|
| 2022 |
Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, ... ... Lyssiotis CA, et al. Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells. Nature Cancer. 3: 1386-1403. PMID 36411320 DOI: 10.1038/s43018-022-00463-1 |
0.839 |
|
| 2022 |
Raghavan KS, Francescone R, Franco-Barraza J, Gardiner JC, Vendramini-Costa DB, Luong T, Pourmandi N, Andren A, Kurimchak A, Ogier C, Campbell PM, Duncan JS, Lyssiotis CA, Languino LR, Cukierman E. NetrinG1 cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress. Cancer Research Communications. 2: 1017-1036. PMID 36310768 DOI: 10.1158/2767-9764.crc-21-0147 |
0.303 |
|
| 2022 |
Kumar A, Yarosz EL, Andren A, Zhang L, Lyssiotis CA, Chang CH. NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function. Cell Reports. 41: 111516. PMID 36288696 DOI: 10.1016/j.celrep.2022.111516 |
0.338 |
|
| 2022 |
Jiménez JA, Lawlor ER, Lyssiotis CA. Amino acid metabolism in primary bone sarcomas. Frontiers in Oncology. 12: 1001318. PMID 36276057 DOI: 10.3389/fonc.2022.1001318 |
0.318 |
|
| 2022 |
Guo AH, Baliira R, Skinner ME, Kumar S, Andren A, Zhang L, Goldsmith RS, Michan S, Davis NJ, Maccani MW, Day SM, Sinclair DA, Brody MJ, Lyssiotis CA, Stein AB, et al. Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload. Scientific Reports. 12: 12258. PMID 35851833 DOI: 10.1038/s41598-022-16506-7 |
0.553 |
|
| 2022 |
Yoshida T, Kawabe T, Cantley LC, Lyssiotis CA. Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP-Dependent Malic Enzyme 1. Biochemistry. 61: 1548-1553. PMID 35819845 DOI: 10.1021/acs.biochem.2c00123 |
0.42 |
|
| 2022 |
Kerk S, Lin L, Myers AL, Sutton DJ, Andren A, Sajjakulnukit P, Zhang L, Zhang Y, Jiménez JA, Nelson BS, Chen B, Robinson A, Thurston G, Kemp SB, Steele NG, ... ... Lyssiotis CA, et al. Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context. Elife. 11. PMID 35815941 DOI: 10.7554/eLife.73245 |
0.842 |
|
| 2022 |
Vaziri-Gohar A, Cassel J, Mohammed FS, Zarei M, Hue JJ, Hajihassani O, Graor HJ, Srikanth YVV, Karim SA, Abbas A, Prendergast E, Chen V, Katayama ES, Dukleska K, Khokhar I, ... ... Lyssiotis CA, et al. Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors. Nature Cancer. PMID 35681100 DOI: 10.1038/s43018-022-00393-y |
0.37 |
|
| 2022 |
Kremer DM, Lyssiotis CA. Targeting allosteric regulation of cancer metabolism. Nature Chemical Biology. 18: 441-450. PMID 35484254 DOI: 10.1038/s41589-022-00997-6 |
0.781 |
|
| 2022 |
Golbourn BJ, Halbert ME, Halligan K, Varadharajan S, Krug B, Mbah NE, Kabir N, Stanton AJ, Locke AL, Casillo SM, Zhao Y, Sanders LM, Cheney A, Mullett SJ, Chen A, ... ... Lyssiotis C, et al. Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome. Nature Cancer. PMID 35422502 DOI: 10.1038/s43018-022-00348-3 |
0.329 |
|
| 2022 |
Velez-Delgado A, Donahue KL, Du W, Irizarry-Negron V, Menjivar RE, Lasse Opsahl EL, Steele NG, The S, Lazarus J, Sirihorachai VR, Yan W, Kemp SB, Kerk SA, Bollampally M, Yang S, ... ... Lyssiotis CA, et al. Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming. Cellular and Molecular Gastroenterology and Hepatology. PMID 35245687 DOI: 10.1016/j.jcmgh.2022.02.016 |
0.315 |
|
| 2022 |
Boyer S, Lee HJ, Steele N, Zhang L, Sajjakulnukit P, Andren A, Ward MH, Singh R, Basrur V, Zhang Y, Nesvizhskii AI, Pasca di Magliano M, Halbrook CJ, Lyssiotis CA. Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway. Elife. 11. PMID 35156921 DOI: 10.7554/eLife.73796 |
0.758 |
|
| 2022 |
Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Posada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, ... ... Lyssiotis CA, et al. Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis. Nature Cancer. 2: 1243. PMID 35122065 DOI: 10.1038/s43018-021-00283-9 |
0.561 |
|
| 2022 |
Mbah NE, Lyssiotis CA. Metabolic regulation of ferroptosis in the tumor microenvironment. The Journal of Biological Chemistry. 298: 101617. PMID 35065965 DOI: 10.1016/j.jbc.2022.101617 |
0.407 |
|
| 2021 |
Bell HN, Rebernick RJ, Goyert J, Singhal R, Kuljanin M, Kerk SA, Huang W, Das NK, Andren A, Solanki S, Miller SL, Todd PK, Fearon ER, Lyssiotis CA, Gygi SP, et al. Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance. Cancer Cell. PMID 34951957 DOI: 10.1016/j.ccell.2021.12.001 |
0.314 |
|
| 2021 |
Kim PK, Halbrook CJ, Kerk SA, Radyk M, Wisner S, Kremer DM, Sajjakulnukit P, Andren A, Hou SW, Trivedi A, Thurston G, Anand A, Yan L, Salamanca-Cardona L, Welling SD, ... ... Lyssiotis C, et al. Hyaluronic acid fuels pancreatic cancer cell growth. Elife. 10. PMID 34951587 DOI: 10.7554/eLife.62645 |
0.838 |
|
| 2021 |
Scott AJ, Lyssiotis CA, Wahl DR. Clinical Targeting of Altered Metabolism in High-Grade Glioma. Cancer Journal (Sudbury, Mass.). 27: 386-394. PMID 34570453 DOI: 10.1097/PPO.0000000000000550 |
0.323 |
|
| 2021 |
Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, ... ... Lyssiotis CA, et al. GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nature Communications. 12: 4860. PMID 34381026 DOI: 10.1038/s41467-021-24859-2 |
0.83 |
|
| 2021 |
Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, ... ... Lyssiotis CA, et al. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS. Nature Cancer. 2: 414-428. PMID 34179825 DOI: 10.1038/s43018-021-00183-y |
0.593 |
|
| 2021 |
Devenport SN, Singhal R, Radyk MD, Taranto JG, Kerk SA, Chen B, Goyert JW, Jain C, Das NK, Oravecz-Wilson K, Zhang L, Greenson JK, Chen YE, Soleimanpour SA, Reddy P, ... Lyssiotis CA, et al. Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress. Jci Insight. PMID 34138755 DOI: 10.1172/jci.insight.138835 |
0.411 |
|
| 2021 |
Kemp SB, Carpenter ES, Steele NG, Donahue KL, Nwosu ZC, Pacheco A, Velez-Delgado A, Menjivar RE, Lima F, The S, Espinoza CE, Brown K, Long D, Lyssiotis CA, Rao A, et al. Apolipoprotein E promotes immune suppression in pancreatic cancer through NF-kB-mediated production of CXCL1. Cancer Research. PMID 34049975 DOI: 10.1158/0008-5472.CAN-20-3929 |
0.301 |
|
| 2021 |
Puca F, Yu F, Bartolacci C, Pettazzoni P, Carugo A, Huang-Hobbs E, Liu J, Zanca C, Carbone F, Del Poggetto E, Gumin J, Dasgupta P, Seth S, Srinivasan S, Lang FF, ... ... Lyssiotis CA, et al. Medium-chain acyl CoA dehydrogenase protects mitochondria from lipid peroxidation in glioblastoma. Cancer Discovery. PMID 34039636 DOI: 10.1158/2159-8290.CD-20-1437 |
0.778 |
|
| 2021 |
Giblin W, Bringman-Rodenbarger L, Guo AH, Kumar S, Monovich AC, Mostafa AM, Skinner ME, Azar M, Mady AS, Chung CH, Kadambi N, Melong KA, Lee HJ, Zhang L, Sajjakulnukit P, ... ... Lyssiotis CA, et al. The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics. The Journal of Clinical Investigation. PMID 33945506 DOI: 10.1172/JCI138926 |
0.794 |
|
| 2021 |
Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metabolism. PMID 33609439 DOI: 10.1016/j.cmet.2021.02.001 |
0.712 |
|
| 2021 |
Steele NG, Biffi G, Kemp SB, Zhang Y, Drouillard D, Syu LJ, Hao Y, Oni TE, Brosnan E, Elyada E, Doshi A, Hansma C, Espinoza C, Abbas A, The S, ... ... Lyssiotis CA, et al. Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33495315 DOI: 10.1158/1078-0432.CCR-20-3715 |
0.729 |
|
| 2021 |
Purohit V, Wang L, Yang H, Li J, Ney GM, Gumkowski ER, Vaidya AJ, Wang A, Bhardwaj A, Zhao E, Dolgalev I, Zamperone A, Abel EV, Magliano MPD, Crawford HC, ... ... Lyssiotis CA, et al. ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer. Genes & Development. PMID 33446568 DOI: 10.1101/gad.344184.120 |
0.761 |
|
| 2020 |
Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, Nwosu ZC, Zhang L, Czerwonka A, Pawłowska A, Xia H, Li J, Liao P, Yu J, Vatan L, ... ... Lyssiotis CA, et al. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature. PMID 32879489 DOI: 10.1038/S41586-020-2682-1 |
0.759 |
|
| 2020 |
Chung C, Sweha SR, Pratt D, Tamrazi B, Panwalkar P, Banda A, Bayliss J, Hawes D, Yang F, Lee HJ, Shan M, Cieslik M, Qin T, Werner CK, Wahl DR, ... Lyssiotis CA, et al. Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas. Cancer Cell. PMID 32795401 DOI: 10.1016/J.Ccell.2020.07.008 |
0.308 |
|
| 2020 |
Zhou W, Yao Y, Scott AJ, Wilder-Romans K, Dresser JJ, Werner CK, Sun H, Pratt D, Sajjakulnukit P, Zhao SG, Davis M, Nelson BS, Halbrook CJ, Zhang L, Gatto F, ... ... Lyssiotis CA, et al. Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nature Communications. 11: 3811. PMID 32732914 DOI: 10.1038/S41467-020-17512-X |
0.786 |
|
| 2020 |
Khoa LTP, Tsan YC, Mao F, Kremer DM, Sajjakulnukit P, Zhang L, Zhou B, Tong X, Bhanu NV, Choudhary C, Garcia BA, Yin L, Smith GD, Saunders TL, Bielas SL, ... Lyssiotis CA, et al. Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation. Cell Stem Cell. PMID 32610040 DOI: 10.1016/J.Stem.2020.06.005 |
0.734 |
|
| 2020 |
Little AC, Kovalenko I, Goo LE, Hong HS, Kerk SA, Yates JA, Purohit V, Lombard DB, Merajver SD, Lyssiotis CA. High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions. Communications Biology. 3: 271. PMID 32472013 DOI: 10.1038/s42003-020-0988-z |
0.808 |
|
| 2020 |
Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, ... ... Lyssiotis CA, et al. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science (New York, N.Y.). 368: 85-89. PMID 32241947 DOI: 10.1126/Science.Aaw9872 |
0.803 |
|
| 2020 |
Zhou Z, Torres M, Sha H, Halbrook CJ, Van den Bergh F, Reinert RB, Yamada T, Wang S, Luo Y, Hunter AH, Wang C, Sanderson TH, Liu M, Taylor A, Sesaki H, ... Lyssiotis CA, et al. Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes. Science (New York, N.Y.). PMID 32193362 DOI: 10.1126/Science.Aay2494 |
0.652 |
|
| 2020 |
Wubben TJ, Pawar M, Weh E, Smith A, Sajjakulnukit P, Zhang L, Dai L, Hager H, Pai MP, Lyssiotis CA, Besirli CG. Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis. Scientific Reports. 10: 2990. PMID 32076076 DOI: 10.1038/s41598-020-59999-w |
0.327 |
|
| 2020 |
Zhang Y, Lazarus J, Steele NG, Yan W, Lee HJ, Nwosu ZC, Halbrook CJ, Menjivar RE, Kemp SB, Sirihorachai V, Velez-Delgado A, Donahue K, Carpenter ES, Brown KL, Irizarry-Negron V, ... ... Lyssiotis CA, et al. Regulatory T cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis. Cancer Discovery. PMID 31911451 DOI: 10.1158/2159-8290.Cd-19-0958 |
0.729 |
|
| 2020 |
Nelson BS, Lin L, Kremer DM, Sousa CM, Cotta-Ramusino C, Myers A, Ramos J, Gao T, Kovalenko I, Wilder-Romans K, Dresser J, Davis M, Lee HJ, Nwosu ZC, Campit S, ... ... Lyssiotis CA, et al. Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy. Cancer & Metabolism. 8: 1. PMID 31908776 DOI: 10.1186/S40170-019-0202-2 |
0.802 |
|
| 2020 |
Badgley M, DelGiorno K, Wahl G, Lyssiotis C, Olive KP. Abstract 5711: Therapeutic induction of tumor-selective ferroptosis in models of pancreatic cancer Cancer Research. 80: 5711-5711. DOI: 10.1158/1538-7445.Am2020-5711 |
0.465 |
|
| 2019 |
Lyssiotis CA, Nagrath D. Metabolic Reprogramming and Vulnerabilities in Cancer. Cancers. 12. PMID 31905922 DOI: 10.3390/Cancers12010090 |
0.339 |
|
| 2019 |
Yoshida T, Yamasaki S, Kaneko O, Taoka N, Tomimoto Y, Namatame I, Yahata T, Kuromitsu S, Cantley LC, Lyssiotis CA. A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth. Biochemical and Biophysical Research Communications. PMID 31787239 DOI: 10.1016/J.Bbrc.2019.11.130 |
0.522 |
|
| 2019 |
Halbrook CJ, Wahl DR, Lyssiotis CA. Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer. Trends in Biochemical Sciences. PMID 31699584 DOI: 10.1016/J.Tibs.2019.10.007 |
0.726 |
|
| 2019 |
Walter LA, Lin YH, Halbrook CJ, Chuh KN, He L, Pedowitz NJ, Batt AR, Brennan CK, Stiles BL, Lyssiotis CA, Pratt MR. Inhibiting the hexosamine biosynthetic pathway lowers O-GlcNAcylation levels and sensitizes cancer to environmental stress. Biochemistry. PMID 31625393 DOI: 10.1021/Acs.Biochem.9B00560 |
0.697 |
|
| 2019 |
Lee HJ, Kremer DM, Sajjakulnukit P, Zhang L, Lyssiotis CA. A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics. Metabolomics : Official Journal of the Metabolomic Society. 15: 103. PMID 31289941 DOI: 10.1007/s11306-019-1564-8 |
0.712 |
|
| 2019 |
Purohit V, Simeone DM, Lyssiotis CA. Metabolic Regulation of Redox Balance in Cancer. Cancers. 11. PMID 31288436 DOI: 10.3390/Cancers11070955 |
0.783 |
|
| 2019 |
Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, et al. Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. Cancer Cell. 35: 916-931.e9. PMID 31185214 DOI: 10.1016/J.Ccell.2019.05.002 |
0.504 |
|
| 2019 |
Xu J, Reznik E, Lee HJ, Gundem G, Jonsson P, Sarungbam J, Bialik A, Sanchez-Vega F, Creighton CJ, Hoekstra JG, Zhang L, Sajjakulnukit P, Kremer D, Tolstyka ZP, Casuscelli J, ... ... Lyssiotis C, et al. Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma. Elife. 8. PMID 30924768 DOI: 10.7554/Elife.38986 |
0.814 |
|
| 2019 |
Kumar A, Pyaram K, Yarosz EL, Hong H, Lyssiotis CA, Giri S, Chang CH. Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function. Proceedings of the National Academy of Sciences of the United States of America. PMID 30910955 DOI: 10.1073/pnas.1901376116 |
0.33 |
|
| 2019 |
Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, ... ... Lyssiotis CA, et al. Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer. Cell Metabolism. PMID 30827862 DOI: 10.1016/J.Cmet.2019.02.001 |
0.81 |
|
| 2019 |
Núñez FJ, Mendez FM, Kadiyala P, Alghamri MS, Savelieff MG, Garcia-Fabiani MB, Haase S, Koschmann C, Calinescu AA, Kamran N, Saxena M, Patel R, Carney S, Guo MZ, Edwards M, ... ... Lyssiotis CA, et al. IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response. Science Translational Medicine. 11. PMID 30760578 DOI: 10.1126/Scitranslmed.Aaq1427 |
0.724 |
|
| 2019 |
Yuan M, Kremer DM, Huang H, Breitkopf SB, Ben-Sahra I, Manning BD, Lyssiotis CA, Asara JM. Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS. Nature Protocols. PMID 30683937 DOI: 10.1038/S41596-018-0102-X |
0.727 |
|
| 2019 |
Fujiwara H, Mathew AV, Kovalenko I, Anupama P, Peltier D, Kim S, Taylor A, Oravecz-Wilson K, Sun Y, Lyssiotis C, Rehemtulla A, Pennarthur S, Reddy P. Mitochondrial Complex II in Intestinal Epithelial Cells Is a Critical Metabolic Checkpoint That Regulates Severity of Gastrointestinal Graft-Versus-Host Disease Blood. 134: 584-584. DOI: 10.1182/Blood-2019-126775 |
0.38 |
|
| 2019 |
Halbrook CJ, Menjivar R, Thurston G, Magliano MPd, Lyssiotis C. Abstract PR13: Macrophage metabolism inhibits pancreatic cancer therapy Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-Pr13 |
0.506 |
|
| 2019 |
Steele N, Kemp S, Irizarry-Negron V, Sirihorachai V, Abbas A, Carpenter E, Halbrook C, Espinoza C, Lyssiotis C, Crawford H, Frankel T, Bednar F, Allen B, Magliano MPd. Abstract A52: Modulation of Hedgehog signaling alters immune infiltration in pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A52 |
0.748 |
|
| 2019 |
Menjivar RE, Halbrook C, Velez A, Lima F, Espinoza C, Galban S, Zhang Y, Lyssiotis C, Magliano MPd. Abstract A31: Investigating the effect of myeloid Arg1 deletion on tumor growth and CD8+ T-cell infiltration and activation in pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A31 |
0.754 |
|
| 2019 |
Nunez F, Garcia-Fabiani M, Kadiyala P, Hong H, Comba A, Lyssiotis C, Cheng S, Lowenstein P, Castro M. RDNA-03. AUTOPHAGY AS A NOVEL THERAPEUTIC TARGET IN MUTANT IDH1 GLIOMAS Neuro-Oncology. 21: vi207-vi207. DOI: 10.1093/Neuonc/Noz175.863 |
0.467 |
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| 2019 |
Steele N, Irizarry-Negron V, Sirihorachai V, Kemp S, Carpenter E, Halbrook C, Lyssiotis C, Bednar F, Frankel T, Allen B, Pasca di Magliano M. 3373 Modulation of Hedgehog Signaling Alters Immune Infiltration in Pancreatic Cancer Journal of Clinical and Translational Science. 3: 16-16. DOI: 10.1017/cts.2019.40 |
0.727 |
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| 2018 |
Santana-Codina N, Roeth AA, Zhang Y, Yang A, Mashadova O, Asara JM, Wang X, Bronson RT, Lyssiotis CA, Ying H, Kimmelman AC. Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis. Nature Communications. 9: 4945. PMID 30470748 DOI: 10.1038/S41467-018-07472-8 |
0.425 |
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| 2018 |
Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA. Biochemical Characterization and Structure-based Mutational Analysis Provides Insight into Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. PMID 30365304 DOI: 10.2210/Pdb6Dnd/Pdb |
0.822 |
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| 2018 |
Nelson BS, Kremer DM, Lyssiotis CA. New tricks for an old drug. Nature Chemical Biology. 14: 990-991. PMID 30297874 DOI: 10.1038/s41589-018-0137-x |
0.745 |
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| 2018 |
Perusina Lanfranca M, Thompson JK, Bednar F, Halbrook C, Lyssiotis C, Levi B, Frankel TL. Metabolism and Epigenetics of Pancreatic Cancer Stem Cells. Seminars in Cancer Biology. PMID 30273655 DOI: 10.1016/J.Semcancer.2018.09.008 |
0.786 |
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| 2018 |
Anglin J, Zavareh RB, Sander PN, Haldar D, Mullarky E, Cantley LC, Kimmelman AC, Lyssiotis CA, Lairson LL. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorganic & Medicinal Chemistry Letters. PMID 29731362 DOI: 10.1016/J.Bmcl.2018.04.061 |
0.75 |
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| 2018 |
Halbrook CJ, Nwosu ZC, Lyssiotis CA. Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation. Trends in Endocrinology and Metabolism: Tem. PMID 29692332 DOI: 10.1016/j.tem.2018.04.002 |
0.708 |
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| 2018 |
Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, ... ... Lyssiotis CA, et al. Menin regulates the serine biosynthetic pathway in Ewing sarcoma. The Journal of Pathology. PMID 29672864 DOI: 10.1002/Path.5085 |
0.817 |
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| 2018 |
Halbrook CJ, Pasca di Magliano M, Lyssiotis CA. TUMOR CROSSTALK NETWORKS PROMOTE GROWTH AND SUPPORT IMMUNE EVASION IN PANCREATIC CANCER. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 29543507 DOI: 10.1152/ajpgi.00416.2017 |
0.719 |
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| 2018 |
Schofield HK, Zeller J, Espinoza C, Halbrook CJ, Del Vecchio A, Magnuson B, Fabo T, Daylan AEC, Kovalenko I, Lee HJ, Yan W, Feng Y, Karim SA, Kremer DM, Kumar-Sinha C, ... Lyssiotis CA, et al. Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma. Jci Insight. 3. PMID 29367463 DOI: 10.1172/Jci.Insight.97422 |
0.802 |
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| 2017 |
Shan M, Lyssiotis CA. When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade. Cell Metabolism. 26: 811-813. PMID 29211980 DOI: 10.1016/j.cmet.2017.11.008 |
0.355 |
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| 2017 |
Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 29087350 DOI: 10.1073/Pnas.1716009114 |
0.817 |
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| 2017 |
Maj T, Wang W, Crespo J, Zhang H, Wang W, Wei S, Zhao L, Vatan L, Shao I, Szeliga W, Lyssiotis C, Liu JR, Kryczek I, Zou W. Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor. Nature Immunology. PMID 29083399 DOI: 10.1038/Ni.3868 |
0.414 |
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| 2017 |
Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Lyssiotis CA, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 392. PMID 28898700 DOI: 10.1016/J.Ccell.2017.08.008 |
0.772 |
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| 2017 |
Lyssiotis CA, Kimmelman AC. Metabolic Interactions in the Tumor Microenvironment. Trends in Cell Biology. PMID 28734735 DOI: 10.1016/j.tcb.2017.06.003 |
0.336 |
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| 2017 |
Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Reports. 20: 721-736. PMID 28723573 DOI: 10.1016/J.Celrep.2017.06.074 |
0.642 |
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| 2017 |
Bringman-Rodenbarger LR, Guo AH, Lyssiotis CA, Lombard DB. Emerging roles for SIRT5 in metabolism and cancer. Antioxidants & Redox Signaling. PMID 28707979 DOI: 10.1089/Ars.2017.7264 |
0.815 |
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| 2017 |
Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Lyssiotis CA, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 71-87.e7. PMID 28697344 DOI: 10.1016/J.Ccell.2017.06.004 |
0.797 |
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| 2017 |
Franchi L, Monteleone I, Hao LY, Spahr MA, Zhao W, Liu X, Demock K, Kulkarni A, Lesch CA, Sanchez B, Carter L, Marafini I, Hu X, Mashadova O, Yuan M, ... ... Lyssiotis CA, et al. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis. Journal of Immunology (Baltimore, Md. : 1950). PMID 28242647 DOI: 10.4049/Jimmunol.1600810 |
0.336 |
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| 2017 |
Halbrook CJ, Lyssiotis CA. Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. Cancer Cell. 31: 5-19. PMID 28073003 DOI: 10.1016/j.ccell.2016.12.006 |
0.75 |
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| 2017 |
Li M, Chiang Y, Lyssiotis C, Teater M, Shen H, Wang L, Hong JY, Jin H, Duy C, Mistry S, Cerchietti L, Cross J, Cantley L, Lin H, Melnick A. SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls Blood. 130: 643-643. DOI: 10.1182/Blood.V130.Suppl_1.643.643 |
0.604 |
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| 2016 |
Wahl DR, Dresser J, Wilder-Romans K, Parsels JD, Zhao SG, Davis M, Zhao L, Kachman M, Wernisch S, Burant CF, Morgan MA, Feng FY, Speers C, Lyssiotis CA, Lawrence TS. Glioblastoma therapy can be augmented by targeting IDH1-mediated NADPH biosynthesis. Cancer Research. PMID 27923831 DOI: 10.1158/0008-5472.Can-16-2008 |
0.334 |
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| 2016 |
Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. PMID 27706144 DOI: 10.1038/nature19851 |
0.819 |
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| 2016 |
Mullarky E, Lairson LL, Cantley LC, Lyssiotis CA. A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase. Molecular & Cellular Oncology. 3: e1164280. PMID 27652319 DOI: 10.1080/23723556.2016.1164280 |
0.738 |
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| 2016 |
Meyer KA, Neeley CK, Baker NA, Washabaugh AR, Flesher CG, Nelson BS, Frankel TL, Lumeng CN, Lyssiotis CA, Wynn ML, Rhim AD, O'Rourke RW. Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer. Biochemistry and Biophysics Reports. 7: 144-149. PMID 27617308 DOI: 10.1016/j.bbrep.2016.06.004 |
0.814 |
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| 2016 |
Lien EC, Lyssiotis CA, Cantley LC. Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 207: 39-72. PMID 27557534 DOI: 10.1007/978-3-319-42118-6_3 |
0.575 |
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| 2016 |
Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. PMID 27509858 DOI: 10.1038/Nature19084 |
0.831 |
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| 2016 |
Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, et al. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402769 DOI: 10.1073/Pnas.1522223113 |
0.398 |
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| 2016 |
Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nature Cell Biology. PMID 27088857 DOI: 10.1038/Ncb3341 |
0.678 |
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| 2016 |
Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, ... Lyssiotis CA, et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831078 DOI: 10.1073/Pnas.1521548113 |
0.827 |
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| 2016 |
Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, et al. Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell. 164: 433-446. PMID 26824656 DOI: 10.1186/2049-3002-2-S1-P86 |
0.524 |
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| 2016 |
Meyer KA, Neeley CK, Baker NA, Washabaugh AR, Flesher CG, Nelson BS, Frankel TL, Lumeng CN, Lyssiotis CA, Wynn ML, Rhim AD, O'Rourke RW. Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer Biochemistry and Biophysics Reports. 7: 144-149. DOI: 10.1016/j.bbrep.2016.06.004 |
0.814 |
|
| 2015 |
Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, ... ... Lyssiotis CA, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Seminars in Cancer Biology. 35: S276-304. PMID 26590477 DOI: 10.1016/J.Semcancer.2015.09.007 |
0.718 |
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| 2015 |
Chakrabarti G, Moore ZR, Luo X, Ilcheva M, Ali A, Padanad M, Zhou Y, Xie Y, Burma S, Scaglioni PP, Cantley LC, DeBerardinis RJ, Kimmelman AC, Lyssiotis CA, Boothman DA. Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone. Cancer & Metabolism. 3: 12. PMID 26462257 DOI: 10.1186/S40170-015-0137-1 |
0.521 |
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| 2015 |
Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002 |
0.727 |
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| 2015 |
Sadanandam A, Wullschleger S, Lyssiotis CA, Grotzinger C, Barbi S, Bersani S, Korner J, Wafy I, Mafficini A, Lawlor RT, Simbolo M, Asara JM, Blaker H, Cantley LC, Wiedenmann B, et al. A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics. Cancer Discovery. PMID 26446169 DOI: 10.1158/2159-8290.Cd-15-0068 |
0.635 |
|
| 2015 |
Viale A, Pettazzoni P, Lyssiotis C, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Heffernan T, Kimmelman A, Wang H, Fleming J, Cantley L, et al. Abstract PR13: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-Pr13 |
0.603 |
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| 2015 |
Moore Z, Chakrabarti G, Lyssiotis C, Deberardinis R, David BA. Abstract B47: Modulating the NQO1-dependent ‘kiss of death’ mechanism of action of NQO1 bioactivatable drugs Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-B47 |
0.481 |
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| 2014 |
Lyssiotis CA, Cantley LC. Acetate fuels the cancer engine. Cell. 159: 1492-4. PMID 25525870 DOI: 10.1016/J.Cell.2014.12.009 |
0.423 |
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| 2014 |
Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 514: 628-32. PMID 25119024 DOI: 10.1038/Nature13611 |
0.526 |
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| 2014 |
Lyssiotis CA, Cantley LC. Targeting metabolic scavenging in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6-8. PMID 24166909 DOI: 10.1158/1078-0432.Ccr-13-2570 |
0.549 |
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| 2014 |
Lyssiotis C, Son J, Mancias J, Ying H, Kimmelman A, Cantley L. Pancreatic cancers depend on a non-canonical glutamine metabolism pathway Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-P44 |
0.618 |
|
| 2013 |
Lyssiotis CA, Cantley LC. Metabolic syndrome: F stands for fructose and fat. Nature. 502: 181-2. PMID 24108049 DOI: 10.1038/502181A |
0.424 |
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| 2013 |
Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL. A regenerative approach to the treatment of multiple sclerosis. Nature. 502: 327-32. PMID 24107995 DOI: 10.1038/Nature12647 |
0.775 |
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| 2013 |
Yeo H, Lyssiotis CA, Zhang Y, Ying H, Asara JM, Cantley LC, Paik JH. FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells. The Embo Journal. 32: 2589-602. PMID 24013118 DOI: 10.1038/Emboj.2013.186 |
0.511 |
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| 2013 |
Lyssiotis CA, Son J, Cantley LC, Kimmelman AC. Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance. Cell Cycle (Georgetown, Tex.). 12: 1987-8. PMID 23759579 DOI: 10.4161/Cc.25307 |
0.489 |
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| 2013 |
Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, et al. Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. The Journal of Biological Chemistry. 288: 17360-71. PMID 23640882 DOI: 10.1074/Jbc.M112.441469 |
0.397 |
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| 2013 |
Sadanandam A, Lyssiotis CA, Homicsko K, Collisson EA, Gibb WJ, Wullschleger S, Ostos LC, Lannon WA, Grotzinger C, Del Rio M, Lhermitte B, Olshen AB, Wiedenmann B, Cantley LC, Gray JW, et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nature Medicine. 19: 619-25. PMID 23584089 DOI: 10.1038/Nm.3175 |
0.621 |
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| 2013 |
Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 496: 101-5. PMID 23535601 DOI: 10.1038/Nature12040 |
0.572 |
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| 2013 |
Lairson LL, Lyssiotis CA, Zhu S, Schultz PG. Small molecule-based approaches to adult stem cell therapies. Annual Review of Pharmacology and Toxicology. 53: 107-25. PMID 23294307 DOI: 10.1146/Annurev-Pharmtox-011112-140300 |
0.753 |
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| 2013 |
Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (New York, N.Y.). 339: 222-6. PMID 23118012 DOI: 10.1126/Science.1226603 |
0.654 |
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| 2013 |
Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, et al. Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway Nature. 499: 504-504. DOI: 10.1038/Nature12317 |
0.525 |
|
| 2012 |
Lyssiotis CA, Cantley LC. SIRT6 puts cancer metabolism in the driver's seat. Cell. 151: 1155-6. PMID 23217699 DOI: 10.1016/J.Cell.2012.11.020 |
0.555 |
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| 2012 |
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology. 14: 1295-304. PMID 23178880 DOI: 10.1038/Ncb2629 |
0.398 |
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| 2012 |
Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, et al. Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discovery. 2: 1048-63. PMID 22915751 DOI: 10.1158/2159-8290.Cd-11-0336 |
0.461 |
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| 2012 |
Lyssiotis CA, Vander-Heiden MG, Heiden MG, Muñoz-Pinedo C, Emerling BM. Emerging concepts: linking hypoxic signaling and cancer metabolism. Cell Death & Disease. 3: e303. PMID 22552280 DOI: 10.1038/Cddis.2012.41 |
0.415 |
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| 2012 |
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 149: 656-70. PMID 22541435 DOI: 10.1016/J.Cell.2012.01.058 |
0.676 |
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| 2012 |
Lyssiotis C, Ying H, Kimmelman A, DePinho R, Cantley L. Abstract A51: Oncogenic Kras is required for pancreatic tumor maintenance through the regulation of anabolic glucose metabolism. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A51 |
0.599 |
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| 2012 |
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. Erratum: ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect Nature Cell Biology. 15: 124-124. DOI: 10.1038/Ncb2677 |
0.34 |
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| 2012 |
Lyssiotis CA, Vander-Heiden MG, Muñoz-Pinedo C, Emerling BM. Erratum: Emerging concepts: linking hypoxic signaling and cancer metabolism Cell Death & Disease. 3: e329-e329. DOI: 10.1038/CDDIS.2012.75 |
0.304 |
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| 2011 |
Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell. 44: 290-303. PMID 22017875 DOI: 10.1016/J.Molcel.2011.08.030 |
0.717 |
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| 2011 |
Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/Ng.890 |
0.77 |
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| 2011 |
Staerk J, Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, et al. Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells. Angewandte Chemie (International Ed. in English). 50: 5734-6. PMID 21547985 DOI: 10.1002/Anie.201101042 |
0.788 |
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| 2011 |
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Chemical control of stem cell fate and developmental potential. Angewandte Chemie (International Ed. in English). 50: 200-42. PMID 21184400 DOI: 10.1002/Anie.201004284 |
0.805 |
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| 2011 |
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. ChemInform Abstract: Chemical Control of Stem Cell Fate and Developmental Potential Cheminform. 42: no-no. DOI: 10.1002/chin.201116267 |
0.682 |
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| 2010 |
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Chemische Kontrolle des Schicksals und Entwicklungspotenzials von Stammzellen Angewandte Chemie. 123: 210-256. DOI: 10.1002/Ange.201004284 |
0.741 |
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| 2009 |
Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, Lyssiotis CA, Yan F, Tu BP, Miraglia L, Walker J, Sun F, Orth A, Schultz PG, Wu X. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. Proceedings of the National Academy of Sciences of the United States of America. 106: 17025-30. PMID 19805117 DOI: 10.1073/Pnas.0909292106 |
0.811 |
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| 2009 |
Lyssiotis CA, Foreman RK, Staerk J, Garcia M, Mathur D, Markoulaki S, Hanna J, Lairson LL, Charette BD, Bouchez LC, Bollong M, Kunick C, Brinker A, Cho CY, Schultz PG, et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proceedings of the National Academy of Sciences of the United States of America. 106: 8912-7. PMID 19447925 DOI: 10.1073/Pnas.0903860106 |
0.783 |
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| 2009 |
Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, Wu X, Schultz PG. A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell. 4: 416-26. PMID 19427291 DOI: 10.1016/J.Stem.2009.04.001 |
0.791 |
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| 2007 |
Lyssiotis CA, Walker J, Wu C, Kondo T, Schultz PG, Wu X. Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells Proceedings of the National Academy of Sciences of the United States of America. 104: 14982-14987. PMID 17855562 DOI: 10.1073/Pnas.0707044104 |
0.556 |
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