Year |
Citation |
Score |
2023 |
Kuburich NA, den Hollander P, Castaneda M, Pietilä M, Tang X, Batra H, Martínez-Peña F, Visal TH, Zhou T, Demestichas BR, Dontula RV, Liu JY, Maddela JJ, Padmanabhan RS, Phi LTH, ... ... Lairson LL, et al. Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas. Cell Reports. 42: 113470. PMID 37979166 DOI: 10.1016/j.celrep.2023.113470 |
0.796 |
|
2023 |
Tang J, Li W, Chiu TY, Martínez-Peña F, Luo Z, Chong CT, Wei Q, Gazaniga N, West TJ, See YY, Lairson LL, Parker CG, Baran PS. Author Correction: Synthesis of portimines reveals the basis of their anti-cancer activity. Nature. PMID 37798445 DOI: 10.1038/s41586-023-06699-w |
0.772 |
|
2023 |
Bertin P, Rector-Brooks J, Sharma D, Gaudelet T, Anighoro A, Gross T, Martínez-Peña F, Tang EL, Suraj MS, Regep C, Hayter JBR, Korablyov M, Valiante N, van der Sloot A, Tyers M, ... ... Lairson LL, et al. RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. Cell Reports Methods. 100599. PMID 37797618 DOI: 10.1016/j.crmeth.2023.100599 |
0.783 |
|
2023 |
Tang J, Li W, Chiu TY, Martínez-Peña F, Luo Z, Chong CT, Wei Q, Gazaniga N, West TJ, See YY, Lairson LL, Parker CG, Baran PS. Synthesis of portimines reveals the basis of their anti-cancer activity. Nature. PMID 37730997 DOI: 10.1038/s41586-023-06535-1 |
0.8 |
|
2023 |
Spangenberg SH, Palermo A, Gazaniga NR, Martínez-Peña F, Guijas C, Chin EN, Rinschen MM, Sander PN, Webb B, Pereira LE, Jia Y, Meitz L, Siuzdak G, Lairson LL. Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux. Cell Chemical Biology. PMID 37467751 DOI: 10.1016/j.chembiol.2023.06.016 |
0.753 |
|
2023 |
Jo J, Kim J, Ibrahim L, Kumar M, Iaconelli J, So Tran C, Ryong Moon H, Jung Y, Luke Wiseman R, Lairson LL, Chatterjee AK, Bollong MJ, Yun H. Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators. Bioorganic & Medicinal Chemistry Letters. 129306. PMID 37116763 DOI: 10.1016/j.bmcl.2023.129306 |
0.805 |
|
2023 |
West TJ, Bi J, Martínez-Peña F, Curtis EJ, Gazaniga NR, Mischel PS, Lairson LL. A Cell Type Selective YM155 Prodrug Targets Receptor-Interacting Protein Kinase 2 to Induce Brain Cancer Cell Death. Journal of the American Chemical Society. PMID 37017374 DOI: 10.1021/jacs.2c11715 |
0.819 |
|
2022 |
Beyer BA, Lairson LL. Promoting remyelination: A case study in regenerative medicine. Current Opinion in Chemical Biology. 70: 102201. PMID 36037558 DOI: 10.1016/j.cbpa.2022.102201 |
0.796 |
|
2022 |
Martínez-Peña F, Pearson AD, Tang EL, Kuburich NA, Mani SA, Schultz PG, Bollong MJ, Lairson LL. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. European Journal of Medicinal Chemistry. 242: 114638. PMID 36001933 DOI: 10.1016/j.ejmech.2022.114638 |
0.81 |
|
2022 |
Chin EN, Sulpizio A, Lairson LL. Targeting STING to promote antitumor immunity. Trends in Cell Biology. PMID 35931610 DOI: 10.1016/j.tcb.2022.06.010 |
0.709 |
|
2021 |
Spangenberg SH, Zavareh RB, Lairson LL. Protocol for high-throughput compound screening using flow cytometry in THP-1 cells. Star Protocols. 2: 100400. PMID 33778785 DOI: 10.1016/j.xpro.2021.100400 |
0.755 |
|
2021 |
Jo J, Ibrahim L, Iaconelli J, Kwak J, Kumar M, Jung Y, Lairson LL, Chatterjee AK, Schultz PG, Bollong MJ, Yun H. Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators. Bioorganic Chemistry. 108: 104614. PMID 33508678 DOI: 10.1016/j.bioorg.2020.104614 |
0.801 |
|
2020 |
Zavareh RB, Spangenberg SH, Woods A, Martínez-Peña F, Lairson LL. HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins. Cell Chemical Biology. PMID 33113406 DOI: 10.1016/j.chembiol.2020.10.005 |
0.809 |
|
2020 |
Chin EN, Yu C, Vartabedian VF, Jia Y, Kumar M, Gamo AM, Vernier W, Ali SH, Kissai M, Lazar DC, Nguyen N, Pereira LE, Benish B, Woods AK, Joseph SB, ... ... Lairson LL, et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science (New York, N.Y.). 369: 993-999. PMID 32820126 DOI: 10.1126/Science.Abb4255 |
0.764 |
|
2020 |
Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, ... ... Lairson LL, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. PMID 32730809 DOI: 10.1016/J.Cell.2020.07.001 |
0.803 |
|
2020 |
Huffman BJ, Chen S, Schwarz JL, Plata RE, Chin EN, Lairson LL, Houk KN, Shenvi RA. Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists. Nature Chemistry. PMID 32042135 DOI: 10.1038/S41557-019-0413-8 |
0.701 |
|
2020 |
Kuburich NA, Rosolen M, Martinez F, Hollander Pd, Bollong MJ, Soundararajan R, Lairson LL, Mani SA. Abstract 5043: A vimentin binding small molecule (FiVe1) is a novel candidate to target CSC-rich TNBC Cancer Research. 80: 5043-5043. DOI: 10.1158/1538-7445.Am2020-5043 |
0.77 |
|
2019 |
Marro BS, Zak J, Zavareh RB, Teijaro JR, Lairson LL, Oldstone MBA. Discovery of Small Molecules for the Reversal of T Cell Exhaustion. Cell Reports. 29: 3293-3302.e3. PMID 31801090 DOI: 10.1016/J.Celrep.2019.10.119 |
0.682 |
|
2019 |
Lucki NC, Villa GR, Vergani N, Bollong MJ, Beyer BA, Lee JW, Anglin JL, Spangenberg SH, Chin EN, Sharma A, Johnson K, Sander PN, Gordon P, Skirboll SL, Wurdak H, ... ... Lairson LL, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 30846550 DOI: 10.1073/Pnas.1816626116 |
0.759 |
|
2019 |
Palermo A, Spangenberg S, Guijas C, Lairson L, Siuzdak G. A Network of Endogenous Metabolites Modulates Programmed Death-Ligand 1 (PD-L1) Expression in Monocytic Leukemia Biophysical Journal. 116: 308a. DOI: 10.1016/J.Bpj.2018.11.1667 |
0.728 |
|
2018 |
Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA. Biochemical Characterization and Structure-based Mutational Analysis Provides Insight into Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. PMID 30365304 DOI: 10.2210/Pdb6Dnd/Pdb |
0.807 |
|
2018 |
Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. PMID 30323285 DOI: 10.1038/S41586-018-0622-0 |
0.785 |
|
2018 |
Anglin J, Zavareh RB, Sander PN, Haldar D, Mullarky E, Cantley LC, Kimmelman AC, Lyssiotis CA, Lairson LL. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorganic & Medicinal Chemistry Letters. PMID 29731362 DOI: 10.1016/J.Bmcl.2018.04.061 |
0.81 |
|
2017 |
Beyer BA, Fang M, Sadrian B, Montenegro-Burke JR, Plaisted WC, Kok BPC, Saez E, Kondo T, Siuzdak G, Lairson LL. Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation. Nature Chemical Biology. PMID 29131145 DOI: 10.1038/Nchembio.2517 |
0.782 |
|
2017 |
Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 29087350 DOI: 10.1073/Pnas.1716009114 |
0.826 |
|
2017 |
Lum KM, Sato Y, Beyer BA, Plaisted WC, Anglin JL, Lairson LL, Cravatt BF. Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. Acs Chemical Biology. PMID 28930429 DOI: 10.1021/Acschembio.7B00581 |
0.782 |
|
2017 |
Bollong MJ, Yang B, Vergani N, Beyer BA, Chin EN, Zambaldo C, Wang D, Chatterjee AK, Lairson LL, Schultz PG. Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 114: 4679-4684. PMID 28416697 DOI: 10.1073/Pnas.1702750114 |
0.775 |
|
2016 |
Mullarky E, Lairson LL, Cantley LC, Lyssiotis CA. A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase. Molecular & Cellular Oncology. 3: e1164280. PMID 27652319 DOI: 10.1080/23723556.2016.1164280 |
0.646 |
|
2016 |
Bompiani KM, Caglic D, Krutein MC, Benoni G, Hrones M, Lairson LL, Bian H, Smith GR, Dickerson TJ. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. Acs Combinatorial Science. PMID 27314875 DOI: 10.1021/Acscombsci.6B00033 |
0.415 |
|
2016 |
Mullarky E, Lucki NC, Zavareh RB, Anglin JL, Gomes AP, Nicolay BN, Wong JCY, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, ... ... Lairson LL, et al. Erratum: Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (1778-1783) DOI:10.1073/pnas.1521548113) Proceedings of the National Academy of Sciences of the United States of America. 113. PMID 26951666 DOI: 10.1073/Pnas.1602228113 |
0.353 |
|
2016 |
Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, ... ... Lairson LL, et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831078 DOI: 10.1073/Pnas.1521548113 |
0.814 |
|
2015 |
Bollong MJ, Yun H, Sherwood L, Woods AK, Lairson LL, Schultz PG. A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer. Acs Chemical Biology. 10: 2193-8. PMID 26270491 DOI: 10.1021/Acschembio.5B00448 |
0.825 |
|
2014 |
CagliÄ D, Krutein MC, Bompiani KM, Barlow DJ, Benoni G, Pelletier JC, Reitz AB, Lairson LL, Houseknecht KL, Smith GR, Dickerson TJ. Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain. Journal of Medicinal Chemistry. 57: 669-76. PMID 24387280 DOI: 10.1021/Jm4012164 |
0.339 |
|
2013 |
Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL. A regenerative approach to the treatment of multiple sclerosis. Nature. 502: 327-32. PMID 24107995 DOI: 10.1038/Nature12647 |
0.786 |
|
2013 |
Lairson LL, Lyssiotis CA, Zhu S, Schultz PG. Small molecule-based approaches to adult stem cell therapies. Annual Review of Pharmacology and Toxicology. 53: 107-25. PMID 23294307 DOI: 10.1146/Annurev-Pharmtox-011112-140300 |
0.743 |
|
2011 |
Lee HJ, Lairson LL, Rich JR, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC. Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni. The Journal of Biological Chemistry. 286: 35922-32. PMID 21832050 DOI: 10.1074/Jbc.M111.261172 |
0.476 |
|
2011 |
Staerk J, Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, et al. Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells. Angewandte Chemie (International Ed. in English). 50: 5734-6. PMID 21547985 DOI: 10.1002/Anie.201101042 |
0.808 |
|
2011 |
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Chemical control of stem cell fate and developmental potential. Angewandte Chemie (International Ed. in English). 50: 200-42. PMID 21184400 DOI: 10.1002/Anie.201004284 |
0.813 |
|
2011 |
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. ChemInform Abstract: Chemical Control of Stem Cell Fate and Developmental Potential Cheminform. 42: no-no. DOI: 10.1002/chin.201116267 |
0.614 |
|
2010 |
Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Halder R, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proceedings of the National Academy of Sciences of the United States of America. 107: 16542-7. PMID 20823227 DOI: 10.1073/Pnas.1010300107 |
0.781 |
|
2010 |
Wurdak H, Zhu S, Romero A, Lorger M, Watson J, Chiang CY, Zhang J, Natu VS, Lairson LL, Walker JR, Trussell CM, Harsh GR, Vogel H, Felding-Habermann B, Orth AP, et al. An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation. Cell Stem Cell. 6: 37-47. PMID 20085741 DOI: 10.1016/J.Stem.2009.11.002 |
0.805 |
|
2010 |
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Chemische Kontrolle des Schicksals und Entwicklungspotenzials von Stammzellen Angewandte Chemie. 123: 210-256. DOI: 10.1002/Ange.201004284 |
0.74 |
|
2009 |
Chan PH, Lairson LL, Lee HJ, Wakarchuk WW, Strynadka NC, Withers SG, McIntosh LP. NMR spectroscopic characterization of the sialyltransferase CstII from Campylobacter jejuni: histidine 188 is the general base. Biochemistry. 48: 11220-30. PMID 19824695 DOI: 10.1021/Bi901606N |
0.446 |
|
2009 |
Lyssiotis CA, Foreman RK, Staerk J, Garcia M, Mathur D, Markoulaki S, Hanna J, Lairson LL, Charette BD, Bouchez LC, Bollong M, Kunick C, Brinker A, Cho CY, Schultz PG, et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proceedings of the National Academy of Sciences of the United States of America. 106: 8912-7. PMID 19447925 DOI: 10.1073/Pnas.0903860106 |
0.804 |
|
2008 |
Lairson LL, Henrissat B, Davies GJ, Withers SG. Glycosyltransferases: structures, functions, and mechanisms. Annual Review of Biochemistry. 77: 521-55. PMID 18518825 DOI: 10.1146/annurev.biochem.76.061005.092322 |
0.386 |
|
2008 |
Lobsanov Y, Lairson L, Romero P, Sleno B, Yip P, Withers S, Herscovics A, Howell L. Mechanism of retaining glycosyltransferases: structure of Kre2p/Mnt1p in complex with a donor analog Acta Crystallographica Section a Foundations of Crystallography. 64: C276-C277. DOI: 10.1107/S0108767308091162 |
0.345 |
|
2007 |
Chiu CP, Lairson LL, Gilbert M, Wakarchuk WW, Withers SG, Strynadka NC. Structural analysis of the alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni in apo and substrate-analogue bound forms. Biochemistry. 46: 7196-204. PMID 17518445 DOI: 10.1021/Bi602543D |
0.454 |
|
2007 |
Lairson LL, Wakarchuk WW, Withers SG. Alternative donor substrates for inverting and retaining glycosyltransferases Chemical Communications. 365-367. PMID 17220972 DOI: 10.1039/B614636H |
0.42 |
|
2006 |
Lairson LL, Watts AG, Wakarchuk WW, Withers SG. Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis. Nature Chemical Biology. 2: 724-8. PMID 17057723 DOI: 10.1038/Nchembio828 |
0.47 |
|
2006 |
Aharoni A, Thieme K, Chiu CP, Buchini S, Lairson LL, Chen H, Strynadka NC, Wakarchuk WW, Withers SG. High-throughput screening methodology for the directed evolution of glycosyltransferases. Nature Methods. 3: 609-14. PMID 16862135 DOI: 10.1038/Nmeth899 |
0.511 |
|
2006 |
Mildvan AS, Xia Z, Azurmendi HF, Legler PM, Balfour MR, Lairson LL, Withers SG, Gabelli SB, Bianchet MA, Amzel LM. Hydrogen bonding in the mechanism of GDP-mannose mannosyl hydrolase Journal of Molecular Structure. 790: 160-167. DOI: 10.1016/J.Molstruc.2005.09.024 |
0.429 |
|
2005 |
Xia Z, Azurmendi HF, Lairson LL, Withers SG, Gabelli SB, Bianchet MA, Amzel LM, Mildvan AS. Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction. Biochemistry. 44: 8989-97. PMID 15966723 DOI: 10.1021/Bi050583V |
0.425 |
|
2004 |
Lairson LL, Withers SG. Mechanistic analogies amongst carbohydrate modifying enzymes. Chemical Communications (Cambridge, England). 2243-8. PMID 15489968 DOI: 10.1039/B406490A |
0.489 |
|
2004 |
Lairson LL, Chiu CP, Ly HD, He S, Wakarchuk WW, Strynadka NC, Withers SG. Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue. The Journal of Biological Chemistry. 279: 28339-44. PMID 15075344 DOI: 10.1074/Jbc.M400451200 |
0.443 |
|
2004 |
Chiu CP, Watts AG, Lairson LL, Gilbert M, Lim D, Wakarchuk WW, Withers SG, Strynadka NC. Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog. Nature Structural & Molecular Biology. 11: 163-70. PMID 14730352 DOI: 10.1038/Nsmb720 |
0.486 |
|
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