Frederick W. Alt, PhD - Related publications

Affiliations: 
Genetics Harvard University, Cambridge, MA, United States 
Area:
DNA repair, immunology, lymphoma
Website:
https://www.hms.harvard.edu/dms/bbs/fac/Alt.php
NOTE: We are testing a new system for identifying relevant work based on semantic analysis that identifies similarities between recently published papers and the current author's publications. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches.
50 most relevant papers in past 60 days:
Year Citation  Score
2021 Paun A, Claudio E, Siebenlist UK. Constitutive activation of NF-κB during early bone marrow development results in loss of B cells at the pro-B-cell stage. Blood Advances. 5: 745-755. PMID 33560391 DOI: 10.1182/bloodadvances.2020002932   
2021 Yang Y, Li X, Ma Z, Wang C, Yang Q, Byrne-Steele M, Hong R, Min Q, Zhou G, Cheng Y, Qin G, Youngyunpipatkul JV, Wing JB, Sakaguchi S, Toonstra C, et al. CTLA-4 expression by B-1a B cells is essential for immune tolerance. Nature Communications. 12: 525. PMID 33483505 DOI: 10.1038/s41467-020-20874-x   
2021 King HW, Orban N, Riches JC, Clear AJ, Warnes G, Teichmann SA, James LK. Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics. Science Immunology. 6. PMID 33579751 DOI: 10.1126/sciimmunol.abe6291   
2021 An MJ, Shin GS, Lee HM, Kim JW. Ablation of Reduces Cell Viability and Increases UVC-Mediated Apoptosis in Hepatocarcinoma HepG2 Cells. Genes. 12. PMID 33573186 DOI: 10.3390/genes12020201   
2021 Yam-Puc JC, Zhang L, Maqueda-Alfaro RA, Garcia-Ibanez L, Zhang Y, Davies J, Senis YA, Snaith M, Toellner KM. Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death. Iscience. 24: 102038. PMID 33532715 DOI: 10.1016/j.isci.2021.102038   
2021 Sever D, Hershko-Moshe A, Srivastava R, Eldor R, Hibsher D, Keren-Shaul H, Amit I, Bertuzzi F, Krogvold L, Dahl-Jørgensen K, Ben-Dov IZ, Landsman L, Melloul D. NF-κB activity during pancreas development regulates adult β-cell mass by modulating neonatal β-cell proliferation and apoptosis. Cell Death Discovery. 7: 2. PMID 33414444 DOI: 10.1038/s41420-020-00386-9   
2021 Li S, Akrap N, Cerboni S, Porritt MJ, Wimberger S, Lundin A, Möller C, Firth M, Gordon E, Lazovic B, Sieńska A, Pane LS, Coelho MA, Ciotta G, Pellegrini G, et al. Universal toxin-based selection for precise genome engineering in human cells. Nature Communications. 12: 497. PMID 33479216 DOI: 10.1038/s41467-020-20810-z   
2021 Fan L, Wu Q, Kang S, Yang B, Wu C. The phenotypic and functional study of tissue B cells in respiratory system provided important information for diseases and development of vaccines. Journal of Cellular and Molecular Medicine. PMID 33481318 DOI: 10.1111/jcmm.16278   
2021 Michaels AJ, Campbell C, Bou-Puerto R, Rudensky AY. Nuclear receptor LXRβ controls fitness and functionality of activated T cells. The Journal of Experimental Medicine. 218. PMID 33373442 DOI: 10.1084/jem.20201311   
2021 Harris FM, Meagher KA, Zhong M, Daniel BJ, Eckersdorff M, Green JA, Voronina V, Guo C, Limnander A, Macdonald LE. Flow Cytometric Characterization of Murine B Cell Development. Journal of Visualized Experiments : Jove. PMID 33554965 DOI: 10.3791/61565   
2021 Werner L, Dor C, Salamon N, Nagar M, Shouval DS. T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing. Journal of Visualized Experiments : Jove. PMID 33522509 DOI: 10.3791/61792   
2021 Weinguny M, Klanert G, Eisenhut P, Lee I, Timp W, Borth N. Subcloning induces changes in the DNA-methylation pattern of outgrowing Chinese hamster ovary cell colonies. Biotechnology Journal. e2000350. PMID 33484505 DOI: 10.1002/biot.202000350   
2021 Khurana I, Al-Hasani K, Maxwell S, K N H, Okabe J, Cooper ME, Collombat P, El-Osta A. DNA methylation status correlates with adult β-cell regeneration capacity. Npj Regenerative Medicine. 6: 7. PMID 33580013 DOI: 10.1038/s41536-021-00119-1   
2021 Van Hees S, Cuypers B, Bourgeois S, Groothuismink ZMA, Meysman P, Van der Vlies P, de Knegt R, Vonghia L, Michielsen P, Francque S, Laukens K, Boonstra A, Vanwolleghem T. Sorted B cell transcriptomes point towards actively regulated B cell responses during ongoing chronic hepatitis B infections. Cellular Immunology. 362: 104283. PMID 33548734 DOI: 10.1016/j.cellimm.2021.104283   
2021 Norin U, Rintisch C, Meng L, Forster F, Ekman D, Tuncel J, Klocke K, Bäcklund J, Yang M, Bonner MY, Lahore GF, James J, Shchetynsky K, Bergquist M, Gjertsson I, et al. Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation. Nature Communications. 12: 610. PMID 33504785 DOI: 10.1038/s41467-020-20586-2   
2021 Nie Y, Zhao L, Zhang X. B Cell Aberrance in Lupus: the Ringleader and the Solution. Clinical Reviews in Allergy & Immunology. PMID 33534064 DOI: 10.1007/s12016-020-08820-7   
2021 Wang Y, Tong C, Dai H, Wu Z, Han X, Guo Y, Chen D, Wei J, Ti D, Liu Z, Mei Q, Li X, Dong L, Nie J, Zhang Y, et al. Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming. Nature Communications. 12: 409. PMID 33462245 DOI: 10.1038/s41467-020-20696-x   
2021 Chen S, Gan M, Lv H, Jiang R. DeepCAPE: A Deep Convolutional Neural Network for the Accurate Prediction of Enhancers. Genomics, Proteomics & Bioinformatics. PMID 33581335 DOI: 10.1016/j.gpb.2019.04.006   
2021 Vergani S, Yuan J. Developmental changes in the rules for B cell selection. Immunological Reviews. PMID 33501672 DOI: 10.1111/imr.12949   
2021 Cartwright ANR, Suo S, Badrinath S, Kumar S, Melms JC, Luoma A, Bagati A, Saadatpour A, Izar B, Yuan GC, Wucherpfennig KW. Immunosuppressive Myeloid Cells Induce Nitric Oxide-dependent DNA Damage and p53 Pathway Activation in CD8+ T cells. Cancer Immunology Research. PMID 33514509 DOI: 10.1158/2326-6066.CIR-20-0085   
2021 Liu B, Lin Y, Yan J, Yao J, Liu D, Ma W, Wang J, Liu W, Wang C, Zhang L, Qi H. Affinity-coupled CCL22 promotes positive selection in germinal centres. Nature. PMID 33597749 DOI: 10.1038/s41586-021-03239-2   
2021 Wang X, Cabrera FG, Sharp KL, Spencer DM, Foster AE, Bayle JH. Engineering Tolerance toward Allogeneic CAR-T Cells by Regulation of MHC Surface Expression with Human Herpes Virus-8 Proteins. Molecular Therapy : the Journal of the American Society of Gene Therapy. 29: 718-733. PMID 33554868 DOI: 10.1016/j.ymthe.2020.10.019   
2021 Wood E, Kume K, Navarro FJ, Nurse P. Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast. Journal of Cell Science. PMID 33419777 DOI: 10.1242/jcs.251769   
2021 Sutton HJ, Aye R, Idris AH, Vistein R, Nduati E, Kai O, Mwacharo J, Li X, Gao X, Andrews TD, Koutsakos M, Nguyen THO, Nekrasov M, Milburn P, Eltahla A, et al. Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans. Cell Reports. 34: 108684. PMID 33567273 DOI: 10.1016/j.celrep.2020.108684   
2021 Harris E, Zimmerman D, Warga E, Bamezai A, Elmer J. Non-Viral Gene Delivery to T Cells with Lipofectamine LTX. Biotechnology and Bioengineering. PMID 33480049 DOI: 10.1002/bit.27686   
2021 Goldy C, Pedroza-Garcia JA, Breakfield N, Cools T, Vena R, Benfey PN, De Veylder L, Palatnik J, Rodriguez RE. The GRAS-type SCL28 transcription factor controls the mitotic cell cycle and division plane orientation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33526654 DOI: 10.1073/pnas.2005256118   
2021 Alzubi J, Lock D, Rhiel M, Schmitz S, Wild S, Mussolino C, Hildenbeutel M, Brandes C, Rositzka J, Lennartz S, Haas SA, Chmielewski KO, Schaser T, Kaiser A, Cathomen T, et al. Automated generation of gene-edited CAR T cells at clinical scale. Molecular Therapy. Methods & Clinical Development. 20: 379-388. PMID 33575430 DOI: 10.1016/j.omtm.2020.12.008   
2021 Pan L, Hong C, Chan LN, Xiao G, Malvi P, Robinson ME, Geng H, Reddy ST, Lee J, Khairnar V, Cosgun KN, Xu L, Kume K, Sadras T, Wang S, et al. PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33531346 DOI: 10.1073/pnas.2016553118   
2021 Isshiki Y, Melnick A. Epigenetic mechanisms of therapy resistance in diffuse large B cell lymphoma (DLBCL). Current Cancer Drug Targets. PMID 33413063 DOI: 10.2174/1568009620666210106122750   
2021 Wang KL, Tao M, Wei TJ, Wei R. Pancreatic β cell regeneration induced by clinical and preclinical agents. World Journal of Stem Cells. 13: 64-77. PMID 33584980 DOI: 10.4252/wjsc.v13.i1.64   
2021 Bevacqua RJ, Lam JY, Peiris H, Whitener RL, Kim S, Gu X, Friedlander MSH, Kim SK. SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells. Genes & Development. PMID 33446570 DOI: 10.1101/gad.342378.120   
2021 Japp AS, Meng W, Rosenfeld AM, Perry DJ, Thirawatananond P, Bacher RL, Liu C, Gardner JS, , Atkinson MA, Kaestner KH, Brusko TM, Naji A, Luning Prak ET, Betts MR. TCR/BCR dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes. Cell. 184: 827-839.e14. PMID 33545036 DOI: 10.1016/j.cell.2020.11.035   
2021 Allam AH, Charnley M, Pham K, Russell SM. Developing T cells form an immunological synapse for passage through the β-selection checkpoint. The Journal of Cell Biology. 220. PMID 33464309 DOI: 10.1083/jcb.201908108   
2021 Stensland ZC, Cambier JC, Smith MJ. Therapeutic Targeting of Autoreactive B Cells: Why, How, and When? Biomedicines. 9. PMID 33467130 DOI: 10.3390/biomedicines9010083   
2021 Bacchetta R, Weinberg K. Thymic origins of autoimmunity-lessons from inborn errors of immunity. Seminars in Immunopathology. PMID 33532929 DOI: 10.1007/s00281-020-00835-8   
2021 Yoshida Y, Mikami N, Nakanishi Y, Saimoto M, Nagaike A, Shimono H, Nakano S, Tsuji T, Kohno T. Characterization of an expanded IL-10-producing-suppressive T cell population associated with immune tolerance. Biological & Pharmaceutical Bulletin. PMID 33504740 DOI: 10.1248/bpb.b19-01072   
2021 Kushnareva Y, Mathews IT, Andreyev AY, Altay G, Lindestam Arlehamn CS, Pandurangan V, Nilsson R, Jain M, Sette A, Peters B, Sharma S. Functional Analysis of Immune Signature Genes in Th1* Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-γ and IL-17 Production. Journal of Immunology (Baltimore, Md. : 1950). PMID 33547171 DOI: 10.4049/jimmunol.2000672   
2021 Traxel S, Lehmann J, Richard S, Sidorov S, Niggli F, Berger C, Nadal D, Bürgler S. Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis. Cancer Immunology, Immunotherapy : Cii. PMID 33507341 DOI: 10.1007/s00262-020-02835-x   
2021 Granja JM, Corces MR, Pierce SE, Bagdatli ST, Choudhry H, Chang HY, Greenleaf WJ. ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis. Nature Genetics. PMID 33633365 DOI: 10.1038/s41588-021-00790-6   
2021 Sokal A, Chappert P, Barba-Spaeth G, Roeser A, Fourati S, Azzaoui I, Vandenberghe A, Fernandez I, Meola A, Bouvier-Alias M, Crickx E, Beldi-Ferchiou A, Hue S, Languille L, Michel M, et al. Maturation and persistence of the anti-SARS-CoV-2 memory B cell response. Cell. PMID 33571429 DOI: 10.1016/j.cell.2021.01.050   
2021 Huang RS, Lai MC, Shih HA, Lin S. A robust platform for expansion and genome editing of primary human natural killer cells. The Journal of Experimental Medicine. 218. PMID 33433623 DOI: 10.1084/jem.20201529   
2021 Trefzer A, Kadam P, Wang SH, Pennavaria S, Lober B, Akçabozan B, Kranich J, Brocker T, Nakano N, Irmler M, Beckers J, Straub T, Obst R. Dynamic adoption of anergy by antigen-exhausted CD4 T cells. Cell Reports. 34: 108748. PMID 33567282 DOI: 10.1016/j.celrep.2021.108748   
2021 Aslam MA, Alemdehy MF, Kwesi-Maliepaard EM, Muhaimin FI, Caganova M, Pardieck IN, van den Brand T, van Welsem T, de Rink I, Song JY, de Wit E, Arens R, Jacobs H, van Leeuwen F. Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation. Embo Reports. e51184. PMID 33410591 DOI: 10.15252/embr.202051184   
2021 He C, Wang S, Zhou C, He M, Wang J, Ladds M, Lianoudaki D, Sedimbi SK, Lane DP, Westerberg LS, Li S, Karlsson MCI. CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response. Autophagy. PMID 33535890 DOI: 10.1080/15548627.2021.1885183   
2021 FitzPatrick MEB, Provine NM, Garner LC, Powell K, Amini A, Irwin SL, Ferry H, Ambrose T, Friend P, Vrakas G, Reddy S, Soilleux E, Klenerman P, Allan PJ. Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets. Cell Reports. 34: 108661. PMID 33472060 DOI: 10.1016/j.celrep.2020.108661   
2021 van der Horst HJ, de Jonge AV, Hiemstra IH, Gelderloos AT, Berry DRAI, Hijmering NJ, van Essen HF, de Jong D, Chamuleau MED, Zweegman S, Breij ECW, Roemer MGM, Mutis T. Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment. Blood Cancer Journal. 11: 38. PMID 33602901 DOI: 10.1038/s41408-021-00430-6   
2021 Zhang L, Zhang W, Sun J, Liu KN, Gan ZX, Liu YZ, Chang JF, Yang XM, Sun F. Nucleotide variation in histone H2BL drives crossalk of histone modification and promotes tumour cell proliferation by upregulating c-Myc. Life Sciences. 119127. PMID 33515561 DOI: 10.1016/j.lfs.2021.119127   
2021 Kritikou JS, Oliveira MM, Record J, Saeed MB, Nigam SM, He M, Keszei M, Wagner AK, Brauner H, Sendel A, Sedimbi SK, Rentouli S, Lane DP, Snapper SB, Kärre K, et al. Constitutive WASp activation leads to abnormal cytotoxic cells with increased response against tumors. Jci Insight. PMID 33621210 DOI: 10.1172/jci.insight.140273   
2021 Li M, Xu Y, Liang J, Lin H, Qi X, Li F, Han P, Gao Y, Yang X. USP22 deficiency in melanoma mediates resistance to T-cell through IFNγ-JAK1-STAT1 signal axis. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33601053 DOI: 10.1016/j.ymthe.2021.02.018   
2021 Biswas S, Mandal G, Payne KK, Anadon CM, Gatenbee CD, Chaurio RA, Costich TL, Moran C, Harro CM, Rigolizzo KE, Mine JA, Trillo-Tinoco J, Sasamoto N, Terry KL, Marchion D, et al. IgA transcytosis and antigen recognition govern ovarian cancer immunity. Nature. PMID 33536615 DOI: 10.1038/s41586-020-03144-0