| Year |
Citation |
Score |
| 2022 |
Blaha CS, Ramakrishnan G, Jeon SM, Nogueira V, Rho H, Kang S, Bhaskar P, Terry AR, Aissa AF, Frolov MV, Patra KC, Brooks Robey R, Hay N. A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis. Nature Communications. 13: 899. PMID 35173161 DOI: 10.1038/s41467-022-28440-3 |
0.811 |
|
| 2020 |
Chen X, Ariss MM, Ramakrishnan G, Nogueira V, Blaha C, Putzbach W, Islam ABMMK, Frolov MV, Hay N. Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer. Molecular Cell. PMID 32931746 DOI: 10.1016/J.Molcel.2020.08.017 |
0.452 |
|
| 2020 |
Ariss MM, Terry AR, Islam ABMMK, Hay N, Frolov MV. Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development. Journal of Cell Science. PMID 32878945 DOI: 10.1242/Jcs.250837 |
0.452 |
|
| 2019 |
Terry AR, Hay N. Fuelling cancer cells. Nature Reviews. Endocrinology. 15: 71-72. PMID 30560891 DOI: 10.1038/S41574-018-0146-6 |
0.351 |
|
| 2018 |
Pusec CM, De Jesus A, Khan MW, Terry AR, Ludvik AE, Xu K, Giancola N, Pervaiz H, Smith ED, Ding X, Harrison S, Chandel NS, Becker TC, Hay N, Ardehali H, et al. Hepatic HKDC1 expression contributes to liver metabolism. Endocrinology. PMID 30517626 DOI: 10.1210/En.2018-00887 |
0.334 |
|
| 2018 |
Liu SL, Wang ZG, Hu Y, Xin Y, Singaram I, Gorai S, Zhou X, Shim Y, Min JH, Gong LW, Hay N, Zhang J, Cho W. Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt. Molecular Cell. PMID 30174291 DOI: 10.1016/J.Molcel.2018.07.035 |
0.429 |
|
| 2018 |
Mehta MM, Weinberg SE, Steinert EM, Chhiba K, Martinez CA, Gao P, Perlman HR, Bryce P, Hay N, Chandel NS. Hexokinase 2 is dispensable for T cell-dependent immunity. Cancer & Metabolism. 6: 10. PMID 30140438 DOI: 10.1186/S40170-018-0184-5 |
0.344 |
|
| 2018 |
DeWaal D, Nogueira V, Terry AR, Patra KC, Jeon SM, Guzman G, Au J, Long CP, Antoniewicz MR, Hay N. Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin. Nature Communications. 9: 2539. PMID 29946147 DOI: 10.1038/S41467-018-04182-Z |
0.647 |
|
| 2018 |
Petit L, Ma S, Cipi J, Cheng SY, Zieger M, Hay N, Punzo C. Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa. Cell Reports. 23: 2629-2642. PMID 29847794 DOI: 10.1016/J.Celrep.2018.04.111 |
0.313 |
|
| 2018 |
Nogueira V, Patra KC, Hay N. Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation. Elife. 7. PMID 29687779 DOI: 10.7554/Elife.32213 |
0.492 |
|
| 2018 |
Jeon SM, Hay N. Expanding the concepts of cancer metabolism. Experimental & Molecular Medicine. 50: 32. PMID 29657329 DOI: 10.1038/S12276-018-0070-9 |
0.644 |
|
| 2018 |
DeWaal D, Nogueira V, Terry AR, Patra KC, Jeon SM, Guzman G, Au J, Long CP, Antoniewicz MR, Hay N. Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin. Nature Communications. 9: 446. PMID 29386513 DOI: 10.1038/S41467-017-02733-4 |
0.721 |
|
| 2018 |
Sudhahar V, Okur MN, Bagi Z, O'Bryan JP, Hay N, Makino A, Patel VS, Phillips SA, Stepp D, Ushio-Fukai M, Fukai T. Akt2 Stabilizes ATP7A, a Copper Transporter for SOD3 (Extracellular Superoxide Dismutase), in Vascular Smooth Muscles: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29301787 DOI: 10.1161/Atvbaha.117.309819 |
0.334 |
|
| 2018 |
Nogueira V, Patra KC, Hay N. Author response: Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation Elife. DOI: 10.7554/Elife.32213.050 |
0.42 |
|
| 2017 |
Wang Q, Chen X, Hay N. Akt as a target for cancer therapy: more is not always better (lessons from studies in mice). British Journal of Cancer. PMID 28557977 DOI: 10.1038/Bjc.2017.153 |
0.478 |
|
| 2017 |
Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, ... ... Hay N, et al. FGF-dependent metabolic control of vascular development. Nature. PMID 28467822 DOI: 10.1038/Nature22322 |
0.318 |
|
| 2017 |
Alasady MJ, Adipietro KA, Pierce AD, Wilder PT, Hartman KG, Weber DJ, Hay N. Abstract 315: S100B regulates IL-6 signaling via the p90 ribosomal S6 kinase (RSK) in malignant melanoma Cancer Research. 77: 315-315. DOI: 10.1158/1538-7445.Am2017-315 |
0.324 |
|
| 2016 |
Hay N. Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? Nature Reviews. Cancer. PMID 27634447 DOI: 10.1038/Nrc.2016.77 |
0.347 |
|
| 2016 |
Gao F, Artham S, Sabbineni H, Al-Azayzih A, Peng XD, Hay N, Adams RH, Byzova TV, Somanath PR. Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover. Cellular and Molecular Life Sciences : Cmls. PMID 27113546 DOI: 10.1007/S00018-016-2232-Z |
0.342 |
|
| 2016 |
Wang Q, Yu WN, Chen X, Peng XD, Jeon SM, Birnbaum MJ, Guzman G, Hay N. Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms. Cancer Cell. PMID 26996309 DOI: 10.1016/J.Ccell.2016.02.008 |
0.697 |
|
| 2016 |
Kerr BA, West XZ, Kim YW, Zhao Y, Tischenko M, Cull RM, Phares TW, Peng XD, Bernier-Latmani J, Petrova TV, Adams RH, Hay N, Naga Prasad SV, Byzova TV. Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium. Nature Communications. 7: 10960. PMID 26971877 DOI: 10.1038/Ncomms10960 |
0.352 |
|
| 2015 |
Yu WN, Nogueira V, Sobhakumari A, Patra KC, Bhaskar PT, Hay N. Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. Cell Reports. 12: 610-21. PMID 26190111 DOI: 10.1016/J.Celrep.2015.06.057 |
0.822 |
|
| 2015 |
Jeon SM, Hay N. The double-edged sword of AMPK signaling in cancer and its therapeutic implications. Archives of Pharmacal Research. 38: 346-57. PMID 25575627 DOI: 10.1007/S12272-015-0549-Z |
0.719 |
|
| 2015 |
Simon MC, Hay N. Part 3: Targeting Cancer Pathways: Tumor Metabolism and Proliferation Science. 348: 1164-1164. DOI: 10.1126/Science.348.6239.1164-C |
0.397 |
|
| 2014 |
Patra KC, Hay N. The pentose phosphate pathway and cancer. Trends in Biochemical Sciences. 39: 347-54. PMID 25037503 DOI: 10.1016/J.Tibs.2014.06.005 |
0.387 |
|
| 2014 |
Li J, Kim K, Hahm E, Molokie R, Hay N, Gordeuk VR, Du X, Cho J. Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. The Journal of Clinical Investigation. 124: 1483-96. PMID 24642468 DOI: 10.1172/Jci72305 |
0.392 |
|
| 2014 |
Jayarama S, Li LC, Ganesh L, Mardi D, Kanteti P, Hay N, Li P, Prabhakar BS. MADD is a downstream target of PTEN in triggering apoptosis. Journal of Cellular Biochemistry. 115: 261-70. PMID 24038283 DOI: 10.1002/Jcb.24657 |
0.549 |
|
| 2013 |
Patra KC, Hay N. Hexokinase 2 as oncotarget. Oncotarget. 4: 1862-3. PMID 24196563 DOI: 10.18632/Oncotarget.1563 |
0.433 |
|
| 2013 |
Tsen F, Bhatia A, O'Brien K, Cheng CF, Chen M, Hay N, Stiles B, Woodley DT, Li W. Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Molecular and Cellular Biology. 33: 4947-59. PMID 24126057 DOI: 10.1128/Mcb.00559-13 |
0.444 |
|
| 2013 |
Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey RB, Hay N. Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell. 24: 213-28. PMID 23911236 DOI: 10.1016/J.Ccr.2013.06.014 |
0.784 |
|
| 2013 |
Zheng Y, Wang Z, Bie W, Brauer PM, Perez White BE, Li J, Nogueira V, Raychaudhuri P, Hay N, Tonetti DA, Macias V, Kajdacsy-Balla A, Tyner AL. PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer. Cancer Research. 73: 5426-37. PMID 23856248 DOI: 10.1158/0008-5472.Can-13-0443 |
0.377 |
|
| 2013 |
Halasi M, Wang M, Chavan TS, Gaponenko V, Hay N, Gartel AL. ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors. The Biochemical Journal. 454: 201-8. PMID 23772801 DOI: 10.1042/Bj20130282 |
0.435 |
|
| 2013 |
Nogueira V, Hay N. Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4309-14. PMID 23719265 DOI: 10.1158/1078-0432.Ccr-12-1424 |
0.386 |
|
| 2013 |
Halasi M, Pandit B, Wang M, Nogueira V, Hay N, Gartel AL. Combination of oxidative stress and FOXM1 inhibitors induces apoptosis in cancer cells and inhibits xenograft tumor growth. The American Journal of Pathology. 183: 257-65. PMID 23665201 DOI: 10.1016/J.Ajpath.2013.03.012 |
0.476 |
|
| 2013 |
Li J, Kim K, Hahm E, Gordeuk VR, Hay N, Du X, Cho J. Neutrophil Akt2 Plays a Critical Role In Heterotypic Neutrophil-Platelet Interactions During Vascular Inflammation Blood. 122: 321-321. DOI: 10.1182/Blood.V122.21.321.321 |
0.379 |
|
| 2013 |
Patra K, Wang Q, Bhaskar P, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller W, Allen E, Jha A, Smolen G, Clasquin M, Robey R, Hay N. Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer Cancer Cell. 24: 399. DOI: 10.1016/J.Ccr.2013.08.029 |
0.763 |
|
| 2012 |
Jeon SM, Hay N. The dark face of AMPK as an essential tumor promoter. Cellular Logistics. 2: 197-202. PMID 23676995 DOI: 10.4161/Cl.22651 |
0.712 |
|
| 2012 |
Gantner BN, Jin H, Qian F, Hay N, He B, Ye RD. The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin. Journal of Immunology (Baltimore, Md. : 1950). 189: 3104-11. PMID 22904301 DOI: 10.4049/Jimmunol.1201669 |
0.352 |
|
| 2012 |
O'Brien KA, Gartner TK, Hay N, Du X. ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2232-40. PMID 22814751 DOI: 10.1161/Atvbaha.112.254680 |
0.414 |
|
| 2012 |
Jeon SM, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature. 485: 661-5. PMID 22660331 DOI: 10.1038/Nature11066 |
0.729 |
|
| 2012 |
Ding L, Biswas S, Morton RE, Smith JD, Hay N, Byzova TV, Febbraio M, Podrez EA. Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice. Cell Metabolism. 15: 861-72. PMID 22632897 DOI: 10.1016/J.Cmet.2012.04.020 |
0.497 |
|
| 2012 |
Nogueira V, Sundararajan D, Kwan JM, Peng XD, Sarvepalli N, Sonenberg N, Hay N. Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis. The Embo Journal. 31: 1134-46. PMID 22307088 DOI: 10.1038/Emboj.2011.478 |
0.445 |
|
| 2012 |
Xu PZ, Chen ML, Jeon SM, Peng XD, Hay N. The effect Akt2 deletion on tumor development in Pten(+/-) mice. Oncogene. 31: 518-26. PMID 21743498 DOI: 10.1038/onc.2011.243 |
0.715 |
|
| 2011 |
Tzivion G, Hay N. PI3K-AKT-FoxO axis in cancer and aging. Biochimica Et Biophysica Acta. 1813: 1925. PMID 21924992 DOI: 10.1016/J.Bbamcr.2011.08.014 |
0.356 |
|
| 2011 |
O'Brien KA, Stojanovic-Terpo A, Hay N, Du X. An important role for Akt3 in platelet activation and thrombosis. Blood. 118: 4215-23. PMID 21821713 DOI: 10.1182/Blood-2010-12-323204 |
0.403 |
|
| 2011 |
Endersby R, Zhu X, Hay N, Ellison DW, Baker SJ. Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Research. 71: 4106-16. PMID 21507933 DOI: 10.1158/0008-5472.Can-10-3597 |
0.485 |
|
| 2011 |
Hay N. Interplay between FOXO, TOR, and Akt. Biochimica Et Biophysica Acta. 1813: 1965-70. PMID 21440577 DOI: 10.1016/J.Bbamcr.2011.03.013 |
0.418 |
|
| 2011 |
Park HJ, Gusarova G, Wang Z, Carr JR, Li J, Kim KH, Qiu J, Park YD, Williamson PR, Hay N, Tyner AL, Lau LF, Costa RH, Raychaudhuri P. Deregulation of FoxM1b leads to tumour metastasis. Embo Molecular Medicine. 3: 21-34. PMID 21204266 DOI: 10.1002/Emmm.201000107 |
0.365 |
|
| 2011 |
Hay N. Akt isoforms and glucose homeostasis - the leptin connection. Trends in Endocrinology and Metabolism: Tem. 22: 66-73. PMID 20947368 DOI: 10.1016/J.Tem.2010.09.003 |
0.436 |
|
| 2011 |
O'Brien KA, Hay N, Du X. The Role of Akt3 in Mediating Outside-in Signaling of the Platelet Integrin αIIbβ3 Blood. 118: 1134-1134. DOI: 10.1182/Blood.V118.21.1134.1134 |
0.429 |
|
| 2010 |
Woodard J, Joshi S, Viollet B, Hay N, Platanias LC. AMPK as a therapeutic target in renal cell carcinoma. Cancer Biology & Therapy. 10: 1168-77. PMID 20948309 DOI: 10.4161/Cbt.10.11.13629 |
0.415 |
|
| 2010 |
Hay N. Mnk earmarks eIF4E for cancer therapy. Proceedings of the National Academy of Sciences of the United States of America. 107: 13975-6. PMID 20679238 DOI: 10.1073/Pnas.1008908107 |
0.449 |
|
| 2010 |
Tonic I, Yu WN, Park Y, Chen CC, Hay N. Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci. The Journal of Biological Chemistry. 285: 23790-8. PMID 20495005 DOI: 10.1074/Jbc.M110.104372 |
0.563 |
|
| 2010 |
Li P, Jayarama S, Ganesh L, Mordi D, Carr R, Kanteti P, Hay N, Prabhakar BS. Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4. The Journal of Biological Chemistry. 285: 22713-22. PMID 20484047 DOI: 10.1074/Jbc.M110.105692 |
0.506 |
|
| 2010 |
Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N. FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Developmental Cell. 18: 592-604. PMID 20412774 DOI: 10.1016/J.Devcel.2010.03.008 |
0.816 |
|
| 2010 |
Chen J, Tang H, Hay N, Xu J, Ye RD. Akt isoforms differentially regulate neutrophil functions. Blood. 115: 4237-46. PMID 20332370 DOI: 10.1182/Blood-2009-11-255323 |
0.49 |
|
| 2010 |
Wang Z, Li Y, Banerjee S, Kong D, Ahmad A, Nogueira V, Hay N, Sarkar FH. Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. Journal of Cellular Biochemistry. 109: 726-36. PMID 20052673 DOI: 10.1002/Jcb.22451 |
0.405 |
|
| 2010 |
Hay N. CS3-1 Interplay between Akt, mTOR complexes, and FoxO Cytokine. 52: 38. DOI: 10.1016/J.Cyto.2010.07.156 |
0.336 |
|
| 2009 |
Park HJ, Carr JR, Wang Z, Nogueira V, Hay N, Tyner AL, Lau LF, Costa RH, Raychaudhuri P. FoxM1, a critical regulator of oxidative stress during oncogenesis. The Embo Journal. 28: 2908-18. PMID 19696738 DOI: 10.1038/Emboj.2009.239 |
0.392 |
|
| 2009 |
Bhaskar PT, Nogueira V, Patra KC, Jeon SM, Park Y, Robey RB, Hay N. mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition. Molecular and Cellular Biology. 29: 5136-47. PMID 19620286 DOI: 10.1128/Mcb.01946-08 |
0.809 |
|
| 2009 |
Chen WS, Peng XD, Wang Y, Xu PZ, Chen ML, Luo Y, Jeon SM, Coleman K, Haschek WM, Bass J, Philipson LH, Hay N. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Molecular and Cellular Biology. 29: 3151-62. PMID 19289493 DOI: 10.1128/Mcb.01792-08 |
0.687 |
|
| 2009 |
Robey RB, Hay N. Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. Seminars in Cancer Biology. 19: 25-31. PMID 19130886 DOI: 10.1016/J.Semcancer.2008.11.010 |
0.514 |
|
| 2009 |
Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A. Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells. The Journal of Biological Chemistry. 284: 4052-61. PMID 19074768 DOI: 10.1074/Jbc.M805032200 |
0.52 |
|
| 2008 |
Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, Hay N. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell. 14: 458-70. PMID 19061837 DOI: 10.1016/J.Ccr.2008.11.003 |
0.519 |
|
| 2008 |
Hay N. p53 strikes mTORC1 by employing sestrins. Cell Metabolism. 8: 184-5. PMID 18762019 DOI: 10.1016/J.Cmet.2008.08.010 |
0.345 |
|
| 2008 |
Woodard J, Sassano A, Hay N, Platanias LC. Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4640-9. PMID 18628479 DOI: 10.1158/1078-0432.Ccr-07-5232 |
0.437 |
|
| 2008 |
Kaur S, Sassano A, Dolniak B, Joshi S, Majchrzak-Kita B, Baker DP, Hay N, Fish EN, Platanias LC. Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proceedings of the National Academy of Sciences of the United States of America. 105: 4808-13. PMID 18339807 DOI: 10.1073/Pnas.0710907105 |
0.446 |
|
| 2008 |
Kannan-Thulasiraman P, Dolniak B, Kaur S, Sassano A, Kalvakolanu DV, Hay N, Platanias LC. Role of the translational repressor 4E-BP1 in the regulation of p21(Waf1/Cip1) expression by retinoids. Biochemical and Biophysical Research Communications. 368: 983-9. PMID 18280804 DOI: 10.1016/J.Bbrc.2008.02.028 |
0.368 |
|
| 2008 |
Altman JK, Yoon P, Katsoulidis E, Kroczynska B, Sassano A, Redig AJ, Glaser H, Jordan A, Tallman MS, Hay N, Platanias LC. Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses. The Journal of Biological Chemistry. 283: 1992-2001. PMID 18048359 DOI: 10.1074/Jbc.M705227200 |
0.467 |
|
| 2008 |
Yin H, Stojanovic A, Hay N, Du X. The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation. Blood. 111: 658-65. PMID 17914025 DOI: 10.1182/Blood-2007-04-085514 |
0.412 |
|
| 2008 |
Cotler SJ, Hay N, Xie H, Chen ML, Xu PZ, Layden TJ, Guzman G. Immunohistochemical expression of components of the Akt-mTORC1 pathway is associated with hepatocellular carcinoma in patients with chronic liver disease. Digestive Diseases and Sciences. 53: 844-9. PMID 17763954 DOI: 10.1007/S10620-007-9934-X |
0.356 |
|
| 2008 |
O’Brien KA, Stojanovic A, Hay N, Du X. The Role of Akt3 in Platelet Activation Blood. 112: 2853-2853. DOI: 10.1182/Blood.V112.11.2853.2853 |
0.404 |
|
| 2007 |
Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, Shinoda Y, Kawasaki Y, Ogata N, Hoshi K, Akiyama T, Chen WS, Hay N, Tobe K, Kadowaki T, et al. Akt1 in osteoblasts and osteoclasts controls bone remodeling. Plos One. 2: e1058. PMID 17957242 DOI: 10.1371/Journal.Pone.0001058 |
0.377 |
|
| 2007 |
Somanath PR, Kandel ES, Hay N, Byzova TV. Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. The Journal of Biological Chemistry. 282: 22964-76. PMID 17562714 DOI: 10.1074/Jbc.M700241200 |
0.429 |
|
| 2007 |
Ju X, Katiyar S, Wang C, Liu M, Jiao X, Li S, Zhou J, Turner J, Lisanti MP, Russell RG, Mueller SC, Ojeifo J, Chen WS, Hay N, Pestell RG. Akt1 governs breast cancer progression in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 7438-43. PMID 17460049 DOI: 10.1073/Pnas.0605874104 |
0.534 |
|
| 2007 |
Bhaskar PT, Hay N. The two TORCs and Akt. Developmental Cell. 12: 487-502. PMID 17419990 DOI: 10.1016/J.Devcel.2007.03.020 |
0.79 |
|
| 2007 |
Kaur S, Lal L, Sassano A, Majchrzak-Kita B, Srikanth M, Baker DP, Petroulakis E, Hay N, Sonenberg N, Fish EN, Platanias LC. Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling. The Journal of Biological Chemistry. 282: 1757-68. PMID 17114181 DOI: 10.1074/Jbc.M607365200 |
0.339 |
|
| 2007 |
Yin H, Stojanovic A, Hay N, Du X. The Roles of Akt1 and Akt2 in GPIb-IX-Mediated Platelet Activation Signaling. Blood. 110: 3635-3635. DOI: 10.1182/Blood.V110.11.3635.3635 |
0.402 |
|
| 2006 |
Skeen JE, Bhaskar PT, Chen CC, Chen WS, Peng XD, Nogueira V, Hahn-Windgassen A, Kiyokawa H, Hay N. Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell. 10: 269-80. PMID 17045205 DOI: 10.1016/J.Ccr.2006.08.022 |
0.814 |
|
| 2006 |
Robey RB, Hay N. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene. 25: 4683-96. PMID 16892082 DOI: 10.1038/Sj.Onc.1209595 |
0.492 |
|
| 2006 |
Chen ML, Xu PZ, Peng XD, Chen WS, Guzman G, Yang X, Di Cristofano A, Pandolfi PP, Hay N. The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice. Genes & Development. 20: 1569-74. PMID 16778075 DOI: 10.1101/Gad.1395006 |
0.427 |
|
| 2006 |
Stojanovic A, Marjanovic JA, Brovkovych VM, Peng X, Hay N, Skidgel RA, Du X. A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation. The Journal of Biological Chemistry. 281: 16333-9. PMID 16613861 DOI: 10.1074/Jbc.M512378200 |
0.403 |
|
| 2005 |
Todorovic V, Chen CC, Hay N, Lau LF. The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. The Journal of Cell Biology. 171: 559-68. PMID 16275757 DOI: 10.1083/Jcb.200504015 |
0.432 |
|
| 2005 |
Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, Byzova TV. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nature Medicine. 11: 1188-96. PMID 16227992 DOI: 10.1038/Nm1307 |
0.408 |
|
| 2005 |
Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell. 8: 179-83. PMID 16169463 DOI: 10.1016/J.Ccr.2005.08.008 |
0.509 |
|
| 2005 |
Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. The Journal of Biological Chemistry. 280: 32081-9. PMID 16027121 DOI: 10.1074/Jbc.M502876200 |
0.841 |
|
| 2005 |
Robey RB, Hay N. Mitochondrial hexokinases: guardians of the mitochondria. Cell Cycle (Georgetown, Tex.). 4: 654-8. PMID 15846094 DOI: 10.4161/Cc.4.5.1678 |
0.488 |
|
| 2005 |
Li YM, Zhou BP, Deng J, Pan Y, Hay N, Hung MC. A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Research. 65: 3257-63. PMID 15833858 DOI: 10.1158/0008-5472.Can-04-1284 |
0.502 |
|
| 2005 |
Lal L, Li Y, Smith J, Sassano A, Uddin S, Parmar S, Tallman MS, Minucci S, Hay N, Platanias LC. Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood. 105: 1669-77. PMID 15471950 DOI: 10.1182/Blood-2004-06-2078 |
0.435 |
|
| 2005 |
Stojanovic A, Marjanovic JA, Brokovych V, Skidgel RA, Hay N, Du X. AKT Mediates Platelet Activation by Stimulating Nitric Oxide Synthesis and cGMP Elevation. Blood. 106: 1652-1652. DOI: 10.1182/Blood.V106.11.1652.1652 |
0.395 |
|
| 2005 |
Robey RB, Hay N. Erratum: Akt, hexokinase, mTOR: Targeting cellular energy metabolism for cancer therapy Drug Discovery Today: Disease Mechanisms. 2: 389. DOI: 10.1016/J.Ddmec.2005.05.041 |
0.356 |
|
| 2005 |
Robey RB, Hay N. Akt, hexokinase, mTOR: Targeting cellular energy metabolism for cancer therapy Drug Discovery Today: Disease Mechanisms. 2: 239-246. DOI: 10.1016/J.Ddmec.2005.05.021 |
0.466 |
|
| 2004 |
Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS, Thompson CB, Robey RB, Hay N. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Molecular Cell. 16: 819-30. PMID 15574336 DOI: 10.1016/J.Molcel.2004.11.014 |
0.762 |
|
| 2004 |
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes & Development. 18: 1926-45. PMID 15314020 DOI: 10.1101/Gad.1212704 |
0.433 |
|
| 2004 |
Datta A, Nag A, Pan W, Hay N, Gartel AL, Colamonici O, Mori Y, Raychaudhuri P. Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc. The Journal of Biological Chemistry. 279: 36698-707. PMID 15199070 DOI: 10.1074/Jbc.M312305200 |
0.405 |
|
| 2004 |
King FW, Skeen J, Hay N, Shtivelman E. Inhibition of Chk1 by activated PKB/Akt. Cell Cycle (Georgetown, Tex.). 3: 634-7. PMID 15107605 DOI: 10.4161/Cc.3.5.894 |
0.808 |
|
| 2004 |
Chen J, De S, Damron DS, Chen WS, Hay N, Byzova TV. Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice. Blood. 104: 1703-10. PMID 15105289 DOI: 10.1182/Blood-2003-10-3428 |
0.36 |
|
| 2004 |
Lekmine F, Sassano A, Uddin S, Smith J, Majchrzak B, Brachmann SM, Hay N, Fish EN, Platanias LC. Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Experimental Cell Research. 295: 173-82. PMID 15051500 DOI: 10.1016/J.Yexcr.2003.12.021 |
0.427 |
|
| 2004 |
Majewski N, Nogueira V, Robey RB, Hay N. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Molecular and Cellular Biology. 24: 730-40. PMID 14701745 DOI: 10.1128/Mcb.24.2.730-740.2004 |
0.826 |
|
| 2004 |
Brunelle JK, Santore MT, Budinger GR, Tang Y, Barrett TA, Zong WX, Kandel E, Keith B, Simon MC, Thompson CB, Hay N, Chandel NS. c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1. The Journal of Biological Chemistry. 279: 4305-12. PMID 14627695 DOI: 10.1074/Jbc.M312241200 |
0.386 |
|
| 2003 |
Zazzeroni F, Papa S, Algeciras-Schimnich A, Alvarez K, Melis T, Bubici C, Majewski N, Hay N, De Smaele E, Peter ME, Franzoso G. Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. Blood. 102: 3270-9. PMID 12855571 DOI: 10.1182/Blood-2003-03-0689 |
0.783 |
|
| 2003 |
Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, Jacobs J, Sundararajan D, Chen WS, Crawford SE, Coleman KG, Hay N. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes & Development. 17: 1352-65. PMID 12782654 DOI: 10.1101/Gad.1089403 |
0.813 |
|
| 2003 |
Lekmine F, Uddin S, Sassano A, Parmar S, Brachmann SM, Majchrzak B, Sonenberg N, Hay N, Fish EN, Platanias LC. Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. The Journal of Biological Chemistry. 278: 27772-80. PMID 12759354 DOI: 10.1074/Jbc.M301364200 |
0.444 |
|
| 2002 |
Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CS, Gartel A, Hay N. Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Molecular and Cellular Biology. 22: 7831-41. PMID 12391152 DOI: 10.1128/Mcb.22.22.7831-7841.2002 |
0.789 |
|
| 2002 |
Bryson JM, Coy PE, Gottlob K, Hay N, Robey RB. Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death. The Journal of Biological Chemistry. 277: 11392-400. PMID 11751868 DOI: 10.1074/Jbc.M110927200 |
0.418 |
|
| 2002 |
McClintock DS, Santore MT, Lee VY, Brunelle J, Budinger GR, Zong WX, Thompson CB, Hay N, Chandel NS. Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Molecular and Cellular Biology. 22: 94-104. PMID 11739725 DOI: 10.1128/Mcb.22.1.94-104.2002 |
0.402 |
|
| 2001 |
Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, Roninson I, Weng W, Suzuki R, Tobe K, Kadowaki T, Hay N. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes & Development. 15: 2203-8. PMID 11544177 DOI: 10.1101/Gad.913901 |
0.471 |
|
| 2001 |
Wert M, Kennedy S, Palfrey HC, Hay N. Myc drives apoptosis in PC12 cells in the absence of Max. Oncogene. 20: 3746-50. PMID 11439337 DOI: 10.1038/Sj.Onc.1204466 |
0.48 |
|
| 2001 |
Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes & Development. 15: 1406-18. PMID 11390360 DOI: 10.1101/Gad.889901 |
0.822 |
|
| 2001 |
Kokontis JM, Wagner AJ, O'leary M, Liao S, Hay N. A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function Oncogene. 20: 659-668. PMID 11313999 DOI: 10.1038/Sj.Onc.1204139 |
0.422 |
|
| 2001 |
Gartel AL, Ye X, Goufman E, Shianov P, Hay N, Najmabadi F, Tyner AL. Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proceedings of the National Academy of Sciences of the United States of America. 98: 4510-5. PMID 11274368 DOI: 10.1073/Pnas.081074898 |
0.356 |
|
| 2000 |
Conzen SD, Gottlob K, Kandel ES, Khanduri P, Wagner AJ, O'Leary M, Hay N. Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis. Molecular and Cellular Biology. 20: 6008-18. PMID 10913183 DOI: 10.1128/Mcb.20.16.6008-6018.2000 |
0.409 |
|
| 2000 |
Xie P, Browning DD, Hay N, Mackman N, Ye RD. Activation of NF-κB by bradykinin through a Gα(q)- and Gβγ-dependent pathway that involves phosphoinositide 3-kinase and Akt Journal of Biological Chemistry. 275: 24907-24914. PMID 10801799 DOI: 10.1074/Jbc.M001051200 |
0.468 |
|
| 1999 |
Kandel ES, Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Experimental Cell Research. 253: 210-29. PMID 10579924 DOI: 10.1006/Excr.1999.4690 |
0.525 |
|
| 1999 |
Kennedy SG, Kandel ES, Cross TK, Hay N. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Molecular and Cellular Biology. 19: 5800-10. PMID 10409766 DOI: 10.1128/Mcb.19.8.5800 |
0.547 |
|
| 1999 |
Weihl CC, Ghadge GD, Kennedy SG, Hay N, Miller RJ, Roos RP. Mutant Presenilin-1 Induces Apoptosis and Downregulates Akt/PKB The Journal of Neuroscience. 19: 5360-5369. DOI: 10.1523/Jneurosci.19-13-05360.1999 |
0.414 |
|
| 1998 |
Kokontis JM, Hay N, Liao S. Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest. Molecular Endocrinology (Baltimore, Md.). 12: 941-53. PMID 9658399 DOI: 10.1210/Mend.12.7.0136 |
0.343 |
|
| 1998 |
Eves EM, Xiong W, Bellacosa A, Kennedy SG, Tsichlis PN, Rosner MR, Hay N. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line Molecular and Cellular Biology. 18: 2143-2152. PMID 9528786 DOI: 10.1128/Mcb.18.4.2143 |
0.51 |
|
| 1998 |
Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway Genes and Development. 12: 502-513. PMID 9472019 DOI: 10.1101/Gad.12.4.502 |
0.424 |
|
| 1997 |
Kennedy SG, Wagner AJ, Conzen SD, Jordán J, Bellacosa A, Tsichlis PN, Hay N. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal Genes and Development. 11: 701-713. PMID 9087425 DOI: 10.1101/Gad.11.6.701 |
0.507 |
|
| 1996 |
Eves EM, Boise LH, Thompson CB, Wagner AJ, Hay N, Rosner MR. Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line Journal of Neurochemistry. 67: 1908-1920. PMID 8863495 DOI: 10.1046/J.1471-4159.1996.67051908.X |
0.393 |
|
| 1996 |
Shiyanov P, Bagchi S, Adami G, Kokontis J, Hay N, Arroyo M, Morozov A, Raychaudhuri P. p21 Disrupts the interaction between cdk2 and the E2F-p130 complex. Molecular and Cellular Biology. 16: 737-44. PMID 8622674 DOI: 10.1128/Mcb.16.3.737 |
0.311 |
|
| 1995 |
Xu J, Kim S, Chen M, Rockow S, Yi SE, Wagner AJ, Hay N, Weichselbaum RR, Li W. Blockage of the Early Events of Mitogenic Signaling by Interferon-γ in Macrophages in Response to Colony-Stimulating Factor-1 Blood. 86: 2774-2788. DOI: 10.1182/Blood.V86.7.2774.2774 |
0.446 |
|
| 1994 |
Wagner AJ, Kokontis JM, Hay N. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1 Genes and Development. 8: 2817-2830. PMID 7995520 DOI: 10.1101/Gad.8.23.2817 |
0.427 |
|
| 1993 |
Wagner AJ, Small MB, Hay N. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2 Molecular and Cellular Biology. 13: 2432-2440. PMID 8455620 DOI: 10.1128/Mcb.13.4.2432 |
0.431 |
|
| 1993 |
Amin C, Wagner AJ, Hay N. Sequence-Specific Transcriptional Activation by Myc and Repression by Max Molecular and Cellular Biology. 13: 383-390. PMID 8417337 DOI: 10.1128/Mcb.13.1.383 |
0.329 |
|
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