Robert G. Thorne - Publications

New York University School of Medicine, New York, NY, United States 
extracellular diffusion & convection, drug delivery

22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Nehra G, Andrews S, Rettig J, Gould MN, Haag JD, Howard SP, Thorne RG. Intranasal administration of the chemotherapeutic perillyl alcohol results in selective delivery to the cerebrospinal fluid in rats. Scientific Reports. 11: 6351. PMID 33737566 DOI: 10.1038/s41598-021-85293-4  0.32
2020 Kariolis MS, Wells RC, Getz JA, Kwan W, Mahon CS, Tong R, Kim DJ, Srivastava A, Bedard C, Henne KR, Giese T, Assimon VA, Chen X, Zhang Y, Solanoy H, ... ... Thorne RG, et al. Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys. Science Translational Medicine. 12. PMID 32461332 DOI: 10.1126/Scitranslmed.Aay1359  0.4
2018 Kumar NN, Pizzo M, Nehra G, Wilken-Resman B, Boroumand S, Thorne R. Passive immunotherapies for central nervous system disorders - current delivery challenges and new approaches. Bioconjugate Chemistry. PMID 30265523 DOI: 10.1021/Acs.Bioconjchem.8B00548  0.32
2018 Kumar NN, Lochhead JJ, Pizzo ME, Nehra G, Boroumand S, Greene G, Tnhorne RG. Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30081144 DOI: 10.1016/J.Jconrel.2018.08.006  0.44
2016 Kumar NN, Gautam M, Lochhead JJ, Wolak DJ, Ithapu V, Singh V, Thorne RG. Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery. Scientific Reports. 6: 31732. PMID 27558973 DOI: 10.1038/Srep31732  0.96
2015 Lochhead JJ, Wolak DJ, Pizzo ME, Thorne RG. Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 371-81. PMID 25492117 DOI: 10.1038/Jcbfm.2014.215  0.96
2015 Wolak DJ, Pizzo ME, Thorne RG. Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging. Journal of Controlled Release : Official Journal of the Controlled Release Society. 197: 78-86. PMID 25449807 DOI: 10.1016/j.jconrel.2014.10.034  0.96
2013 Wolak DJ, Thorne RG. Diffusion of macromolecules in the brain: implications for drug delivery. Molecular Pharmaceutics. 10: 1492-504. PMID 23298378 DOI: 10.1021/mp300495e  0.96
2012 Lochhead JJ, Thorne RG. Intranasal delivery of biologics to the central nervous system. Advanced Drug Delivery Reviews. 64: 614-28. PMID 22119441 DOI: 10.1016/J.Addr.2011.11.002  0.96
2008 Thorne RG, Lakkaraju A, Rodriguez-Boulan E, Nicholson C. In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate. Proceedings of the National Academy of Sciences of the United States of America. 105: 8416-21. PMID 18541909 DOI: 10.1073/Pnas.0711345105  0.96
2008 Thorne RG, Hanson LR, Ross TM, Tung D, Frey WH. Delivery of interferon-beta to the monkey nervous system following intranasal administration. Neuroscience. 152: 785-97. PMID 18304744 DOI: 10.1016/j.neuroscience.2008.01.013  0.96
2006 Thorne RG, Nicholson C. In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space. Proceedings of the National Academy of Sciences of the United States of America. 103: 5567-72. PMID 16567637 DOI: 10.1073/pnas.0509425103  0.96
2005 Thorne RG, Hrabetová S, Nicholson C. Diffusion measurements for drug design. Nature Materials. 4: 713; author reply 71. PMID 16195756 DOI: 10.1038/Nmat1490  0.96
2004 Thorne RG, Hrabetová S, Nicholson C. Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging. Journal of Neurophysiology. 92: 3471-81. PMID 15269225 DOI: 10.1152/jn.00352.2004  0.96
2004 Thorne RG, Pronk GJ, Padmanabhan V, Frey WH. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience. 127: 481-96. PMID 15262337 DOI: 10.1016/j.neuroscience.2004.05.029  0.96
2004 Ross TM, Martinez PM, Renner JC, Thorne RG, Hanson LR, Frey WH. Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis. Journal of Neuroimmunology. 151: 66-77. PMID 15145605 DOI: 10.1016/j.jneuroim.2004.02.011  0.96
2001 Thorne RG, Frey WH. Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations. Clinical Pharmacokinetics. 40: 907-46. PMID 11735609 DOI: 10.2165/00003088-200140120-00003  0.96
2001 Liu XF, Fawcett JR, Thorne RG, Frey WH. Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion. Neuroscience Letters. 308: 91-4. PMID 11457567 DOI: 10.1016/S0304-3940(01)01982-6  0.96
2001 Liu XF, Fawcett JR, Thorne RG, DeFor TA, Frey WH. Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage. Journal of the Neurological Sciences. 187: 91-7. PMID 11440750 DOI: 10.1016/S0022-510X(01)00532-9  0.96
2000 Liu X, Fawcett JR, Thorne RG, Frey WH. Intranasal IGF-1 Protects against Transient Focal Cerebral Ischemia in Rats following Middle Cerebral Artery Occlusion (MCAO) Stroke. 32: 352-352. DOI: 10.1161/01.Str.32.Suppl_1.352  0.96
1997 Frey WH, Liu J, Chen X, Thorne RG, Fawcett JR, Ala TA, Rahman YE. Delivery of 125I-NGF to the brain via the olfactory route Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents. 4: 87-92. DOI: 10.3109/10717549709051878  0.96
1995 Thorne RG, Emory CR, Ala TA, Frey WH. Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Research. 692: 278-82. PMID 8548316 DOI: 10.1016/0006-8993(95)00637-6  0.96
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