| Year |
Citation |
Score |
| 2024 |
Badaut J, Ghersi-Egea JF, Thorne RG, Konsman JP. Blood-brain borders: a proposal to address limitations of historical blood-brain barrier terminology. Fluids and Barriers of the Cns. 21: 3. PMID 38183042 DOI: 10.1186/s12987-023-00478-5 |
0.336 |
|
| 2023 |
Chew KS, Wells RC, Moshkforoush A, Chan D, Lechtenberg KJ, Tran HL, Chow J, Kim DJ, Robles-Colmenares Y, Srivastava DB, Tong RK, Tong M, Xa K, Yang A, Zhou Y, ... ... Thorne RG, et al. Author Correction: CD98hc is a target for brain delivery of biotherapeutics. Nature Communications. 14: 5516. PMID 37679403 DOI: 10.1038/s41467-023-41355-x |
0.337 |
|
| 2023 |
Chew KS, Wells RC, Moshkforoush A, Chan D, Lechtenberg KJ, Tran HL, Chow J, Kim DJ, Robles-Colmenares Y, Srivastava DB, Tong RK, Tong M, Xa K, Yang A, Zhou Y, ... ... Thorne RG, et al. CD98hc is a target for brain delivery of biotherapeutics. Nature Communications. 14: 5053. PMID 37598178 DOI: 10.1038/s41467-023-40681-4 |
0.413 |
|
| 2023 |
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, ... ... Thorne RG, et al. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature Neuroscience. PMID 36635496 DOI: 10.1038/s41593-022-01240-0 |
0.331 |
|
| 2022 |
Arguello A, Mahon CS, Calvert MEK, Chan D, Dugas JC, Pizzo ME, Thomsen ER, Chau R, Damo LA, Duque J, Fang M, Giese T, Kim DJ, Liang N, Nguyen HN, ... ... Thorne RG, et al. Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme. The Journal of Experimental Medicine. 219. PMID 35226042 DOI: 10.1084/jem.20211057 |
0.377 |
|
| 2021 |
Nehra G, Andrews S, Rettig J, Gould MN, Haag JD, Howard SP, Thorne RG. Intranasal administration of the chemotherapeutic perillyl alcohol results in selective delivery to the cerebrospinal fluid in rats. Scientific Reports. 11: 6351. PMID 33737566 DOI: 10.1038/s41598-021-85293-4 |
0.656 |
|
| 2021 |
Bourasset F, Auvity S, Thorne RG, Scherrmann JM. Brain Distribution of Drugs: Brain Morphology, Delivery Routes, and Species Differences. Handbook of Experimental Pharmacology. PMID 33474672 DOI: 10.1007/164_2020_402 |
0.41 |
|
| 2020 |
Kariolis MS, Wells RC, Getz JA, Kwan W, Mahon CS, Tong R, Kim DJ, Srivastava A, Bedard C, Henne KR, Giese T, Assimon VA, Chen X, Zhang Y, Solanoy H, ... ... Thorne RG, et al. Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys. Science Translational Medicine. 12. PMID 32461332 DOI: 10.1126/Scitranslmed.Aay1359 |
0.476 |
|
| 2020 |
Ullman JC, Arguello A, Getz JA, Bhalla A, Mahon CS, Wang J, Giese T, Bedard C, Kim DJ, Blumenfeld JR, Liang N, Ravi R, Nugent AA, Davis SS, Ha C, ... ... Thorne RG, et al. Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice. Science Translational Medicine. 12. PMID 32461331 DOI: 10.1126/Scitranslmed.Aay1163 |
0.366 |
|
| 2018 |
Kumar NN, Pizzo M, Nehra G, Wilken-Resman B, Boroumand S, Thorne R. Passive immunotherapies for central nervous system disorders - current delivery challenges and new approaches. Bioconjugate Chemistry. PMID 30265523 DOI: 10.1021/Acs.Bioconjchem.8B00548 |
0.639 |
|
| 2018 |
Abbott NJ, Pizzo ME, Preston JE, Janigro D, Thorne RG. The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic' system? Acta Neuropathologica. PMID 29428972 DOI: 10.1007/S00401-018-1812-4 |
0.481 |
|
| 2017 |
Hannocks MJ, Pizzo ME, Huppert J, Deshpande T, Abbott NJ, Thorne RG, Sorokin L. Molecular characterization of perivascular drainage pathways in the murine brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17749689. PMID 29283289 DOI: 10.1177/0271678X17749689 |
0.37 |
|
| 2017 |
Pizzo ME, Wolak DJ, Kumar NN, Brunette E, Brunnquell CL, Hannocks MJ, Abbott NJ, Meyerand ME, Sorokin L, Stanimirovic DB, Thorne RG. Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport, and osmotic enhancement of delivery. The Journal of Physiology. PMID 29023798 DOI: 10.1113/Jp275105 |
0.502 |
|
| 2016 |
Kumar NN, Gautam M, Lochhead JJ, Wolak DJ, Ithapu V, Singh V, Thorne RG. Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery. Scientific Reports. 6: 31732. PMID 27558973 DOI: 10.1038/Srep31732 |
0.436 |
|
| 2015 |
Lochhead JJ, Wolak DJ, Pizzo ME, Thorne RG. Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 371-81. PMID 25492117 DOI: 10.1038/Jcbfm.2014.215 |
0.478 |
|
| 2015 |
Wolak DJ, Pizzo ME, Thorne RG. Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging. Journal of Controlled Release : Official Journal of the Controlled Release Society. 197: 78-86. PMID 25449807 DOI: 10.1016/j.jconrel.2014.10.034 |
0.56 |
|
| 2013 |
Wolak DJ, Thorne RG. Diffusion of macromolecules in the brain: implications for drug delivery. Molecular Pharmaceutics. 10: 1492-504. PMID 23298378 DOI: 10.1021/mp300495e |
0.533 |
|
| 2012 |
Lochhead JJ, Thorne RG. Intranasal delivery of biologics to the central nervous system. Advanced Drug Delivery Reviews. 64: 614-28. PMID 22119441 DOI: 10.1016/J.Addr.2011.11.002 |
0.467 |
|
| 2008 |
Thorne RG, Lakkaraju A, Rodriguez-Boulan E, Nicholson C. In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate. Proceedings of the National Academy of Sciences of the United States of America. 105: 8416-21. PMID 18541909 DOI: 10.1073/Pnas.0711345105 |
0.564 |
|
| 2008 |
Thorne RG, Hanson LR, Ross TM, Tung D, Frey WH. Delivery of interferon-beta to the monkey nervous system following intranasal administration. Neuroscience. 152: 785-97. PMID 18304744 DOI: 10.1016/j.neuroscience.2008.01.013 |
0.368 |
|
| 2006 |
Thorne RG, Nicholson C. In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space. Proceedings of the National Academy of Sciences of the United States of America. 103: 5567-72. PMID 16567637 DOI: 10.1073/pnas.0509425103 |
0.576 |
|
| 2005 |
Thorne RG, Hrabetová S, Nicholson C. Diffusion measurements for drug design. Nature Materials. 4: 713; author reply 71. PMID 16195756 DOI: 10.1038/Nmat1490 |
0.647 |
|
| 2004 |
Thorne RG, Hrabetová S, Nicholson C. Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging. Journal of Neurophysiology. 92: 3471-81. PMID 15269225 DOI: 10.1152/jn.00352.2004 |
0.7 |
|
| 2004 |
Thorne RG, Pronk GJ, Padmanabhan V, Frey WH. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience. 127: 481-96. PMID 15262337 DOI: 10.1016/j.neuroscience.2004.05.029 |
0.437 |
|
| 2004 |
Ross TM, Martinez PM, Renner JC, Thorne RG, Hanson LR, Frey WH. Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis. Journal of Neuroimmunology. 151: 66-77. PMID 15145605 DOI: 10.1016/j.jneuroim.2004.02.011 |
0.4 |
|
| 2001 |
Thorne RG, Frey WH. Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations. Clinical Pharmacokinetics. 40: 907-46. PMID 11735609 DOI: 10.2165/00003088-200140120-00003 |
0.484 |
|
| 2001 |
Liu XF, Fawcett JR, Thorne RG, Frey WH. Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion. Neuroscience Letters. 308: 91-4. PMID 11457567 DOI: 10.1016/S0304-3940(01)01982-6 |
0.346 |
|
| 2001 |
Liu XF, Fawcett JR, Thorne RG, DeFor TA, Frey WH. Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage. Journal of the Neurological Sciences. 187: 91-7. PMID 11440750 DOI: 10.1016/S0022-510X(01)00532-9 |
0.378 |
|
| 2000 |
Liu X, Fawcett JR, Thorne RG, Frey WH. Intranasal IGF-1 Protects against Transient Focal Cerebral Ischemia in Rats following Middle Cerebral Artery Occlusion (MCAO) Stroke. 32: 352-352. DOI: 10.1161/01.Str.32.Suppl_1.352 |
0.368 |
|
| 1997 |
Frey WH, Liu J, Chen X, Thorne RG, Fawcett JR, Ala TA, Rahman Y. Delivery of125I-NGF to the Brain via the Olfactory Route Drug Delivery. 4: 87-92. DOI: 10.3109/10717549709051878 |
0.314 |
|
| 1997 |
Frey WH, Liu J, Chen X, Thorne RG, Fawcett JR, Ala TA, Rahman YE. Delivery of 125I-NGF to the brain via the olfactory route Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents. 4: 87-92. DOI: 10.3109/10717549709051878 |
0.451 |
|
| 1995 |
Thorne RG, Emory CR, Ala TA, Frey WH. Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Research. 692: 278-82. PMID 8548316 DOI: 10.1016/0006-8993(95)00637-6 |
0.364 |
|
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