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Lucas B. Sullivan, Ph.D. - Publications

Affiliations: 
2013 Integrated Graduate Program in the Life Sciences Northwestern University, Evanston, IL 
Area:
Cell Biology, Biochemistry, Medicine and Surgery
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Uo T, Ojo KK, Sprenger CCT, Soriano Epilepsia K, Perera BGK, Damodarasamy M, Sun S, Kim S, Hogan HH, Hulverson MA, Choi R, Whitman GR, Barrett LK, Michaels SA, Xu LH, ... ... Sullivan LB, et al. A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer. Molecular Cancer Therapeutics. PMID 38507737 DOI: 10.1158/1535-7163.MCT-23-0540  0.337
2023 Hart ML, Quon E, Vigil ABG, Engstrom IA, Newsom OJ, Davidsen K, Hoellerbauer P, Carlisle SM, Sullivan LB. Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells. Elife. 12. PMID 36883551 DOI: 10.7554/eLife.78654  0.484
2022 Li Z, Ji BW, Dixit PD, Tchourine K, Lien EC, Hosios AM, Abbott KL, Rutter JC, Westermark AM, Gorodetsky EF, Sullivan LB, Vander Heiden MG, Vitkup D. Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited. Nature Metabolism. PMID 35739397 DOI: 10.1038/s42255-022-00588-8  0.341
2022 Arnold PK, Jackson BT, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff SP, Endress J, Drill E, Sullivan LB, Finley LWS. A non-canonical tricarboxylic acid cycle underlies cellular identity. Nature. 603: 477-481. PMID 35264789 DOI: 10.1038/s41586-022-04475-w  0.36
2021 Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, ... Sullivan LB, et al. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372: 716-721. PMID 33986176 DOI: 10.1126/science.aaz2740  0.373
2021 Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, et al. Differential Substrate Use in EGF- and Oncogenic KRAS-Stimulated Human Mammary Epithelial Cells. The Febs Journal. PMID 33811729 DOI: 10.1111/febs.15858  0.345
2020 Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferreira R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. Increased demand for NAD relative to ATP drives aerobic glycolysis. Molecular Cell. PMID 33382985 DOI: 10.1016/j.molcel.2020.12.012  0.439
2020 Davidsen K, Sullivan LB. Free Asparagine or Die: Cancer Cells Require Proteasomal Protein Breakdown to Survive Asparagine Depletion. Cancer Discovery. 10: 1632-1634. PMID 33139341 DOI: 10.1158/2159-8290.CD-20-1251  0.415
2020 Li Y, Ivica NA, Dong T, Papageorgiou DP, He Y, Brown DR, Kleyman M, Hu G, Chen WW, Sullivan LB, Del Rosario A, Hammond PT, Vander Heiden MG, Chen J. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Nature Communications. 11: 4837. PMID 32973183 DOI: 10.1038/s41467-020-18607-1  0.37
2020 Augert A, Mathsyaraja H, Ibrahim AH, Freie B, Geuenich MJ, Cheng PF, Alibeckoff SP, Wu N, Hiatt JB, Basom R, Gazdar A, Sullivan LB, Eisenman RN, MacPherson D. MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer. Cancer Cell. PMID 32470392 DOI: 10.1016/J.Ccell.2020.04.016  0.455
2020 Quon E, Hart ML, Sullivan LB. Redox Debt Leads to Metabolic Bankruptcy in Tumors. Trends in Cancer. 6: 359-361. PMID 32348730 DOI: 10.1016/J.Trecan.2020.02.012  0.479
2019 Rossmann MP, Hoi K, Chan V, Perlin JR, Hagedorn EJ, Abraham BJ, Yang S, Sullivan LB, Warren CR, Vyas S, Custo-Creig E, Dorjsuren B, Cowan C, Haigis MC, Young RA, et al. Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1γ Drives Erythropoiesis Blood. 134: 152-152. DOI: 10.1182/Blood-2019-126833  0.459
2018 Sullivan LB. Metabolic Frugality Marks Cancer Cells for Immune Targeting. Cell. 174: 1344-1346. PMID 30193108 DOI: 10.1016/J.Cell.2018.08.023  0.562
2018 Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG. Aspartate is an endogenous metabolic limitation for tumour growth. Nature Cell Biology. PMID 29941931 DOI: 10.1038/S41556-018-0125-0  0.544
2017 McLellan CA, Vincent BM, Solis NV, Lancaster AK, Sullivan LB, Hartland CL, Youngsaye W, Filler SG, Whitesell L, Lindquist S. Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy. Nature Chemical Biology. PMID 29227471 DOI: 10.1038/Nchembio.2534  0.384
2017 Sullivan LB. Extracellular vesicles: Taking metabolism on the road. Nature Chemical Biology. 13: 924-925. PMID 28820875 DOI: 10.1038/Nchembio.2455  0.311
2016 Gui DY, Sullivan LB, Luengo A, Hosios AM, Bush LN, Gitego N, Davidson SM, Freinkman E, Thomas CJ, Vander Heiden MG. Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin. Cell Metabolism. PMID 27746050 DOI: 10.1016/J.Cmet.2016.09.006  0.631
2016 Sullivan LB, Gui DY, Heiden MG. Altered metabolite levels in cancer: implications for tumour biology and cancer therapy. Nature Reviews. Cancer. PMID 27658530 DOI: 10.1038/Nrc.2016.85  0.54
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. PMID 27110680 DOI: 10.1038/Nchembio.2070  0.402
2016 Hecht VC, Sullivan LB, Kimmerling RJ, Kim DH, Hosios AM, Stockslager MA, Stevens MM, Kang JH, Wirtz D, Vander Heiden MG, Manalis SR. Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. The Journal of Cell Biology. 212: 439-47. PMID 26880201 DOI: 10.1083/Jcb.201506118  0.415
2016 Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, et al. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metabolism. PMID 26853747 DOI: 10.1016/J.Cmet.2016.01.007  0.403
2015 Sullivan LB, Gui DY, Hosios AM, Bush LN, Freinkman E, Vander Heiden MG. Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells. Cell. 162: 552-63. PMID 26232225 DOI: 10.1016/J.Cell.2015.07.017  0.441
2014 Sullivan LB, Chandel NS. Mitochondrial reactive oxygen species and cancer. Cancer & Metabolism. 2: 17. PMID 25671107 DOI: 10.1186/2049-3002-2-17  0.651
2014 Luengo A, Sullivan LB, Heiden MG. Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy. Bmc Biology. 12: 82. PMID 25347702 DOI: 10.1186/S12915-014-0082-4  0.565
2014 Mullen AR, Hu Z, Shi X, Jiang L, Boroughs LK, Kovacs Z, Boriack R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS, DeBerardinis RJ. Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Reports. 7: 1679-90. PMID 24857658 DOI: 10.1016/J.Celrep.2014.04.037  0.645
2014 Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife. 3: e02242. PMID 24843020 DOI: 10.7554/Elife.02242  0.666
2014 Sullivan LB, Chandel NS. Mitochondrial metabolism in TCA cycle mutant cancer cells. Cell Cycle (Georgetown, Tex.). 13: 347-8. PMID 24335489 DOI: 10.4161/Cc.27513  0.725
2014 Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS. Author response: Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis Elife. DOI: 10.7554/Elife.02242.019  0.66
2013 Sullivan LB, Martinez-Garcia E, Nguyen H, Mullen AR, Dufour E, Sudarshan S, Licht JD, Deberardinis RJ, Chandel NS. The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Molecular Cell. 51: 236-48. PMID 23747014 DOI: 10.1016/J.Molcel.2013.05.003  0.631
2012 Sullivan LB, Santos JH, Chandel NS. Mitochondria and telomeres: the promiscuous roles of TIN2. Molecular Cell. 47: 823-4. PMID 23020852 DOI: 10.1016/J.Molcel.2012.09.006  0.514
2012 Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 481: 385-8. PMID 22101431 DOI: 10.1038/Nature10642  0.666
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