Hartmut Wekerle, M.D. - Publications

Affiliations: 
Neuroimmunology Max Planck Institute of Neurobiology, Jupiter, FL, United States 
Area:
Multiple Sclerosis

204 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Wekerle H. Vaccination and narcolepsy: Immune link found? Science Translational Medicine. 7: 294fs27. PMID 26136475 DOI: 10.1126/scitranslmed.aac7091  0.52
2015 Hohlfeld R, Wekerle H. [Multiple sclerosis and microbiota. From genome to metagenome?]. Der Nervenarzt. 86: 925-33. PMID 26099498 DOI: 10.1007/s00115-014-4248-7  0.52
2015 Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, ... ... Wekerle H, et al. γ-secretase directly sheds the survival receptor BCMA from plasma cells. Nature Communications. 6: 7333. PMID 26065893 DOI: 10.1038/ncomms8333  0.52
2015 Nicol B, Salou M, Laplaud DA, Wekerle H. The autoimmune concept of multiple sclerosis. Presse MéDicale (Paris, France : 1983). 44: e103-12. PMID 25813101 DOI: 10.1016/j.lpm.2015.02.009  0.52
2015 Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, ... Wekerle H, et al. The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 194: 542-52. PMID 25505277 DOI: 10.4049/jimmunol.1402070  0.52
2014 Mohan H, Friese A, Albrecht S, Krumbholz M, Elliott CL, Arthur A, Menon R, Farina C, Junker A, Stadelmann C, Barnett SC, Huitinga I, Wekerle H, Hohlfeld R, Lassmann H, et al. Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathologica Communications. 2: 168. PMID 25589163 DOI: 10.1186/s40478-014-0168-9  0.52
2014 Koutrolos M, Berer K, Kawakami N, Wekerle H, Krishnamoorthy G. Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS. Acta Neuropathologica Communications. 2: 163. PMID 25476447 DOI: 10.1186/s40478-014-0163-1  0.52
2014 Ben-Nun A, Kaushansky N, Kawakami N, Krishnamoorthy G, Berer K, Liblau R, Hohlfeld R, Wekerle H. From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development. Journal of Autoimmunity. 54: 33-50. PMID 25175979 DOI: 10.1016/j.jaut.2014.06.004  0.52
2014 Perekrest SV, Shteintcaig AD, Kawakami N, Wekerle H, Korneva HA. Morpho-functional characteristics of hypothalamic orexin neurons during experimental autoimmune encephalomyelitis Advances in Neuroimmune Biology. 5: 171-180. DOI: 10.3233/NIB-140089  0.52
2013 Pohl M, Kawakami N, Kitic M, Bauer J, Martins R, Fischer MT, Machado-Santos J, Mader S, Ellwart JW, Misu T, Fujihara K, Wekerle H, Reindl M, Lassmann H, Bradl M. T cell-activation in neuromyelitis optica lesions plays a role in their formation. Acta Neuropathologica Communications. 1: 85. PMID 24367907 DOI: 10.1186/2051-5960-1-85  0.52
2013 Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, et al. MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. The Journal of Experimental Medicine. 210: 2921-37. PMID 24323356 DOI: 10.1084/jem.20130699  0.52
2013 Wekerle H. Tissue hypoxia in autoimmune brain disease: a Columbian discovery? Annals of Neurology. 74: 765-7. PMID 24242899 DOI: 10.1002/ana.24054  0.52
2013 Wekerle H, Berer K, Krishnamoorthy G. Remote control-triggering of brain autoimmune disease in the gut. Current Opinion in Immunology. 25: 683-9. PMID 24161654 DOI: 10.1016/j.coi.2013.09.009  0.52
2013 Wekerle H, Meinl E. Multiple sclerosis: An old drug plays a new trick. Nature. 502: 314-5. PMID 24107991 DOI: 10.1038/nature12694  0.52
2013 Mayer MC, Breithaupt C, Reindl M, Schanda K, Rostásy K, Berger T, Dale RC, Brilot F, Olsson T, Jenne D, Pröbstel AK, Dornmair K, Wekerle H, Hohlfeld R, Banwell B, et al. Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases. Journal of Immunology (Baltimore, Md. : 1950). 191: 3594-604. PMID 24014878 DOI: 10.4049/jimmunol.1301296  0.52
2013 Mues M, Bartholomäus I, Thestrup T, Griesbeck O, Wekerle H, Kawakami N, Krishnamoorthy G. Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator. Nature Medicine. 19: 778-83. PMID 23685843 DOI: 10.1038/nm.3180  0.52
2013 Pesic M, Bartholomäus I, Kyratsous NI, Heissmeyer V, Wekerle H, Kawakami N. 2-photon imaging of phagocyte-mediated T cell activation in the CNS. The Journal of Clinical Investigation. 123: 1192-201. PMID 23454769 DOI: 10.1172/JCI67233  0.52
2013 Neumann H, Wekerle H. Brain microglia: watchdogs with pedigree. Nature Neuroscience. 16: 253-5. PMID 23434975 DOI: 10.1038/nn.3338  0.52
2012 Odoardi F, Sie C, Streyl K, Ulaganathan VK, Schläger C, Lodygin D, Heckelsmiller K, Nietfeld W, Ellwart J, Klinkert WE, Lottaz C, Nosov M, Brinkmann V, Spang R, Lehrach H, ... ... Wekerle H, et al. T cells become licensed in the lung to enter the central nervous system. Nature. 488: 675-9. PMID 22914092 DOI: 10.1038/nature11337  0.52
2012 Hohlfeld R, Wekerle H. β-Amyloid: enemy or remedy? Science Translational Medicine. 4: 145fs24. PMID 22855459 DOI: 10.1126/scitranslmed.3004586  0.52
2012 Wekerle H, Krishnamoorthy G. Brain autoimmunity: the CD8 question(s). Immunity. 37: 8-10. PMID 22840838 DOI: 10.1016/j.immuni.2012.07.002  0.52
2012 Siewert K, Malotka J, Kawakami N, Wekerle H, Hohlfeld R, Dornmair K. Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides. Nature Medicine. 18: 824-8. PMID 22484809 DOI: 10.1038/nm.2720  0.52
2012 Wekerle H, Flügel A, Fugger L, Schett G, Serreze D. Autoimmunity's next top models. Nature Medicine. 18: 66-70. PMID 22227675 DOI: 10.1038/nm.2635  0.52
2011 Liblau RS, Wekerle H, Tisch RM. Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicity. Frontiers in Immunology. 2: 47. PMID 22566837 DOI: 10.3389/fimmu.2011.00047  0.52
2011 Berer K, Mues M, Koutrolos M, Rasbi ZA, Boziki M, Johner C, Wekerle H, Krishnamoorthy G. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 479: 538-41. PMID 22031325 DOI: 10.1038/nature10554  0.52
2011 Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, ... ... Wekerle H, et al. Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology. 77: 580-8. PMID 21795651 DOI: 10.1212/WNL.0b013e318228c0b1  0.52
2011 Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K. Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal of Neuroimmunology. 233: 245-8. PMID 21353315 DOI: 10.1016/j.jneuroim.2011.01.010  0.52
2011 Berer K, Wekerle H, Krishnamoorthy G. B cells in spontaneous autoimmune diseases of the central nervous system. Molecular Immunology. 48: 1332-7. PMID 21146219 DOI: 10.1016/j.molimm.2010.10.025  0.52
2010 Domingues HS, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G. Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. Plos One. 5: e15531. PMID 21209700 DOI: 10.1371/journal.pone.0015531  0.52
2010 Wekerle H, Hohlfeld R. Beneficial brain autoimmunity? Brain : a Journal of Neurology. 133: 2182-4. PMID 20826427 DOI: 10.1093/brain/awq206  0.52
2010 Wekerle H, Sun DM. Fragile privileges: autoimmunity in brain and eye. Acta Pharmacologica Sinica. 31: 1141-8. PMID 20818330 DOI: 10.1038/aps.2010.149  0.52
2010 Mohan H, Krumbholz M, Sharma R, Eisele S, Junker A, Sixt M, Newcombe J, Wekerle H, Hohlfeld R, Lassmann H, Meinl E. Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Brain Pathology (Zurich, Switzerland). 20: 966-75. PMID 20456365 DOI: 10.1111/j.1750-3639.2010.00399.x  0.52
2010 Wekerle H, Hohlfeld R. Zero tolerance (to acetylcholine receptor) and ways to overcome it. Annals of Neurology. 67: 422-4. PMID 20437576 DOI: 10.1002/ana.22025  0.52
2010 Wekerle H, Hohlfeld R. Molecular oracles for multiple sclerosis therapy. Nature Medicine. 16: 376-7. PMID 20376043 DOI: 10.1038/nm0410-376  0.52
2009 Junker A, Krumbholz M, Eisele S, Mohan H, Augstein F, Bittner R, Lassmann H, Wekerle H, Hohlfeld R, Meinl E. MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain : a Journal of Neurology. 132: 3342-52. PMID 19952055 DOI: 10.1093/brain/awp300  0.52
2009 Bartholomäus I, Kawakami N, Odoardi F, Schläger C, Miljkovic D, Ellwart JW, Klinkert WE, Flügel-Koch C, Issekutz TB, Wekerle H, Flügel A. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature. 462: 94-8. PMID 19829296 DOI: 10.1038/nature08478  0.52
2009 Krishnamoorthy G, Wekerle H. EAE: an immunologist's magic eye. European Journal of Immunology. 39: 2031-5. PMID 19672898 DOI: 10.1002/eji.200939568  0.52
2009 Pöllinger B, Krishnamoorthy G, Berer K, Lassmann H, Bösl MR, Dunn R, Domingues HS, Holz A, Kurschus FC, Wekerle H. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. The Journal of Experimental Medicine. 206: 1303-16. PMID 19487416 DOI: 10.1084/jem.20090299  0.52
2009 Krishnamoorthy G, Saxena A, Mars LT, Domingues HS, Mentele R, Ben-Nun A, Lassmann H, Dornmair K, Kurschus FC, Liblau RS, Wekerle H. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nature Medicine. 15: 626-32. PMID 19483694 DOI: 10.1038/nm.1975  0.52
2009 Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M, Kümpfel T, Moldenhauer A, Rader C, Sonderegger P, Pöllmann W, Tiefenthaller C, Bauer J, Lassmann H, Wekerle H, et al. Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proceedings of the National Academy of Sciences of the United States of America. 106: 8302-7. PMID 19416878 DOI: 10.1073/pnas.0901496106  0.52
2009 Tezel G, Ben-Hur T, Gibson GE, Stevens B, Streit WJ, Wekerle H, Bhattacharya SK, Borras T, Burgoyne CF, Caspi RR, Chauhan BC, Clark AF, Crowston J, Danias J, Dick AD, et al. The role of glia, mitochondria, and the immune system in glaucoma Investigative Ophthalmology and Visual Science. 50: 1001-1012. PMID 19244206 DOI: 10.1167/iovs.08-2717  0.52
2009 Bauer M, Brakebusch C, Coisne C, Sixt M, Wekerle H, Engelhardt B, Fässler R. Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. 106: 1920-5. PMID 19179279 DOI: 10.1073/pnas.0808909106  0.52
2008 Wekerle H. Lessons from multiple sclerosis: models, concepts, observations. Annals of the Rheumatic Diseases. 67: iii56-60. PMID 19022815 DOI: 10.1136/ard.2008.098020  0.52
2008 Hohlfeld R, Wekerle H. Reflections on the "intrathymic pathogenesis" of myasthenia gravis. Journal of Neuroimmunology. 201: 21-7. PMID 18644632 DOI: 10.1016/j.jneuroim.2008.05.020  0.52
2008 Obermeier B, Mentele R, Malotka J, Kellermann J, Kümpfel T, Wekerle H, Lottspeich F, Hohlfeld R, Dornmair K. Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nature Medicine. 14: 688-93. PMID 18488038 DOI: 10.1038/nm1714  0.52
2007 Odoardi F, Kawakami N, Klinkert WE, Wekerle H, Flügel A. Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 18625-30. PMID 18000062 DOI: 10.1073/pnas.0705033104  0.52
2007 Junker A, Ivanidze J, Malotka J, Eiglmeier I, Lassmann H, Wekerle H, Meinl E, Hohlfeld R, Dornmair K. Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain : a Journal of Neurology. 130: 2789-99. PMID 17890278 DOI: 10.1093/brain/awm214  0.52
2007 Grundtner R, Dornmair K, Dahm R, Flügel A, Kawakami N, Zeitelhofer M, Schoderboeck L, Nosov M, Selzer E, Willheim M, Kiebler M, Wekerle H, Lassmann H, Bradl M. Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiology of Disease. 28: 261-75. PMID 17889548 DOI: 10.1016/j.nbd.2007.05.006  0.52
2007 Krishnamoorthy G, Holz A, Wekerle H. Experimental models of spontaneous autoimmune disease in the central nervous system. Journal of Molecular Medicine (Berlin, Germany). 85: 1161-73. PMID 17569024 DOI: 10.1007/s00109-007-0218-x  0.52
2007 Wekerle H. [The enigma of arrival: [corrected] the entrance of auto-immune T lymphocytes in central nervous tissues and of their attack against the myelin structures]. Comptes Rendus Biologies. 330: 1-12. PMID 17241944 DOI: 10.1016/j.crvi.2006.10.002  0.52
2007 Odoardi F, Kawakami N, Li Z, Cordiglieri C, Streyl K, Nosov M, Klinkert WE, Ellwart JW, Bauer J, Lassmann H, Wekerle H, Flügel A. Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 104: 920-5. PMID 17213317 DOI: 10.1073/pnas.0608383104  0.52
2007 Wekerle H, Kurschus FC. Animal models of multiple sclerosis Drug Discovery Today: Disease Models. 3: 359-367. DOI: 10.1016/j.ddmod.2006.11.004  0.52
2007 Wekerle H, Flügel A. Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis Molecular Neurology. 475-497. DOI: 10.1016/B978-012369509-3.50032-9  0.52
2007 Wekerle H. Multiple sclerosis: Future directions and prospects Immune Regulation and Immunotherapy in Autoimmune Disease. 497-513. DOI: 10.1007/978-0-387-36003-4_22  0.52
2006 Krishnamoorthy G, Lassmann H, Wekerle H, Holz A. Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. The Journal of Clinical Investigation. 116: 2385-92. PMID 16955140 DOI: 10.1172/JCI28330  0.52
2006 Seitz S, Schneider CK, Malotka J, Nong X, Engel AG, Wekerle H, Hohlfeld R, Dornmair K. Reconstitution of paired T cell receptor alpha- and beta-chains from microdissected single cells of human inflammatory tissues. Proceedings of the National Academy of Sciences of the United States of America. 103: 12057-62. PMID 16882720 DOI: 10.1073/pnas.0604247103  0.52
2006 Hohlfeld R, Kerschensteiner M, Stadelmann C, Lassmann H, Wekerle H. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 27: S1-7. PMID 16708174 DOI: 10.1007/s10072-006-0537-7  0.52
2006 Wekerle H, Linington C. Organ specific autoantigens and the autoreactiveT cell repertoire: the case of myelin oligodendrocyte glycoprotein. European Journal of Immunology. 36: 512-5. PMID 16506289 DOI: 10.1002/eji.200635914  0.52
2006 Lassmann H, Smith K, Wekerle H, Compston A. The pathogenesis of multiple sclerosis: A pandect McAlpine's Multiple Sclerosis. 661-668. DOI: 10.1016/B978-0-443-07271-0.50016-1  0.52
2006 Lassmann H, Wekerle H. The pathology of multiple sclerosis McAlpine's Multiple Sclerosis. 557-599. DOI: 10.1016/B978-0-443-07271-0.50014-8  0.52
2006 Wekerle H, Lassmann H. The immunology of inflammatory demyelinating disease McAlpine's Multiple Sclerosis. 491-555. DOI: 10.1016/B978-0-443-07271-0.50013-6  0.52
2006 Compston A, Wekerle H, McDonald I. The origins of multiple sclerosis: A synthesis McAlpine's Multiple Sclerosis. 273-284. DOI: 10.1016/B978-0-443-07271-0.50007-0  0.52
2006 Compston A, Wekerle H. The genetics of multiple sclerosis McAlpine's Multiple Sclerosis. 113-181. DOI: 10.1016/B978-0-443-07271-0.50005-7  0.52
2006 Compston A, McDonald I, Noseworthy J, Lassmann H, Miller D, Smith K, Wekerle H, Confavreux C. McAlpine's Multiple Sclerosis McAlpine's Multiple Sclerosis 0.52
2005 Hohlfeld R, Wekerle H. Drug insight: using monoclonal antibodies to treat multiple sclerosis. Nature Clinical Practice. Neurology. 1: 34-44. PMID 16932490 DOI: 10.1038/ncpneuro0016  0.52
2005 Hohlfeld R, Kerschensteiner M, Stadelmann C, Lassmann H, Wekerle H. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. Ernst Schering Research Foundation Workshop. 23-38. PMID 16315607  0.52
2005 Farina C, Weber MS, Meinl E, Wekerle H, Hohlfeld R. Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action. The Lancet. Neurology. 4: 567-75. PMID 16109363 DOI: 10.1016/S1474-4422(05)70167-8  0.52
2005 Kawakami N, Odoardi F, Ziemssen T, Bradl M, Ritter T, Neuhaus O, Lassmann H, Wekerle H, Flügel A. Autoimmune CD4+ T cell memory: lifelong persistence of encephalitogenic T cell clones in healthy immune repertoires. Journal of Immunology (Baltimore, Md. : 1950). 175: 69-81. PMID 15972633  0.52
2005 Kawakami N, Nägerl UV, Odoardi F, Bonhoeffer T, Wekerle H, Flügel A. Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. The Journal of Experimental Medicine. 201: 1805-14. PMID 15939794 DOI: 10.1084/jem.20050011  0.52
2005 Wekerle H. Immune pathogenesis of multiple sclerosis. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 26: S1-2. PMID 15883678 DOI: 10.1007/s10072-005-0386-9  0.52
2005 Bradl M, Bauer J, Flügel A, Wekerle H, Lassmann H. Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord. The American Journal of Pathology. 166: 1441-50. PMID 15855644 DOI: 10.1016/S0002-9440(10)62361-9  0.52
2005 Krumbholz M, Theil D, Derfuss T, Rosenwald A, Schrader F, Monoranu CM, Kalled SL, Hess DM, Serafini B, Aloisi F, Wekerle H, Hohlfeld R, Meinl E. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. The Journal of Experimental Medicine. 201: 195-200. PMID 15642740 DOI: 10.1084/jem.20041674  0.52
2005 Wekerle H. Planting and pruning in the brain: MHC antigens involved in synaptic plasticity? Proceedings of the National Academy of Sciences of the United States of America. 102: 3-4. PMID 15623557 DOI: 10.1073/pnas.0408495101  0.52
2004 Aboul-Enein F, Bauer J, Klein M, Schubart A, Flügel A, Ritter T, Kawakami N, Siedler F, Linington C, Wekerle H, Lassmann H, Bradl M. Selective and antigen-dependent effects of myelin degeneration on central nervous system inflammation. Journal of Neuropathology and Experimental Neurology. 63: 1284-96. PMID 15624765  0.52
2004 Hohlfeld R, Wekerle H. Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proceedings of the National Academy of Sciences of the United States of America. 101: 14599-606. PMID 15306684 DOI: 10.1073/pnas.0404874101  0.52
2004 Skulina C, Schmidt S, Dornmair K, Babbe H, Roers A, Rajewsky K, Wekerle H, Hohlfeld R, Goebels N. Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proceedings of the National Academy of Sciences of the United States of America. 101: 2428-33. PMID 14983026 DOI: 10.1073/pnas.0308689100  0.52
2004 Kawakami N, Lassmann S, Li Z, Odoardi F, Ritter T, Ziemssen T, Klinkert WE, Ellwart JW, Bradl M, Krivacic K, Lassmann H, Ransohoff RM, Volk HD, Wekerle H, Linington C, et al. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. The Journal of Experimental Medicine. 199: 185-97. PMID 14734524 DOI: 10.1084/jem.20031064  0.52
2003 Dornmair K, Goebels N, Weltzien HU, Wekerle H, Hohlfeld R. T-cell-mediated autoimmunity: novel techniques to characterize autoreactive T-cell receptors. The American Journal of Pathology. 163: 1215-26. PMID 14507631 DOI: 10.1016/S0002-9440(10)63481-5  0.52
2003 Qin Y, Duquette P, Zhang Y, Olek M, Da RR, Richardson J, Antel JP, Talbot P, Cashman NR, Tourtellotte WW, Wekerle H, Van Den Noort S. Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis. Laboratory Investigation; a Journal of Technical Methods and Pathology. 83: 1081-8. PMID 12861047 DOI: 10.1097/01.LAB.0000077008.24259.0D  0.52
2003 Wekerle H, Hohlfeld R. Molecular mimicry in multiple sclerosis. The New England Journal of Medicine. 349: 185-6. PMID 12853593 DOI: 10.1056/NEJMcibr035136  0.52
2003 Hofbauer M, Wiesener S, Babbe H, Roers A, Wekerle H, Dornmair K, Hohlfeld R, Goebels N. Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 4090-5. PMID 12651958 DOI: 10.1073/pnas.0236183100  0.52
2003 Kerschensteiner M, Stadelmann C, Dechant G, Wekerle H, Hohlfeld R. Neurotrophic cross-talk between the nervous and immune systems: implications for neurological diseases. Annals of Neurology. 53: 292-304. PMID 12601697 DOI: 10.1002/ana.10446  0.52
2002 Wekerle H. Immune protection of the brain--efficient and delicate. The Journal of Infectious Diseases. 186: S140-4. PMID 12424689 DOI: 10.1086/344937  0.52
2002 Wekerle H. Tackling multiple sclerosis. Nature. 420: 39-40. PMID 12422206 DOI: 10.1038/420039a  0.52
2002 Wiendl H, Malotka J, Holzwarth B, Weltzien HU, Wekerle H, Hohlfeld R, Dornmair K. An autoreactive gamma delta TCR derived from a polymyositis lesion. Journal of Immunology (Baltimore, Md. : 1950). 169: 515-21. PMID 12077283 DOI: 10.4049/jimmunol.169.1.515  0.52
2002 Bauer J, Bradl M, Klein M, Leisser M, Deckwerth TL, Wekerle H, Lassmann H. Endoplasmic reticulum stress in PLP-overexpressing transgenic rats: gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes. Journal of Neuropathology and Experimental Neurology. 61: 12-22. PMID 11829340  0.52
2002 Neumann H, Schweigreiter R, Yamashita T, Rosenkranz K, Wekerle H, Barde YA. Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 854-62. PMID 11826115  0.52
2001 Medana I, Martinic MA, Wekerle H, Neumann H. Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. The American Journal of Pathology. 159: 809-15. PMID 11549572 DOI: 10.1016/S0002-9440(10)61755-5  0.52
2001 Kristoferitsch W, Seeldrayers P, Kyriallis K, Brochet B, Confavreux C, Clanet M, Cesaro P, Defer G, Edan G, Lyon-Caen O, Pelletier J, Rumbach L, Roullet E, Vermersch P, Dengler R, ... ... Wekerle H, et al. Double-blind randomized multicenter dose-comparison study of interferon-β-1a (AVONEX): Rationale, design and baseline data Multiple Sclerosis. 7: 179-183. PMID 11475442 DOI: 10.1191/135245801678438410  0.52
2001 Medana I, Li Z, Flügel A, Tschopp J, Wekerle H, Neumann H. Fas ligand (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity. Journal of Immunology (Baltimore, Md. : 1950). 167: 674-81. PMID 11441070  0.52
2001 Sun D, Whitaker JN, Huang Z, Liu D, Coleclough C, Wekerle H, Raine CS. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. Journal of Immunology (Baltimore, Md. : 1950). 166: 7579-87. PMID 11390514  0.52
2001 Hohlfeld R, Wekerle H. Immunological update on multiple sclerosis. Current Opinion in Neurology. 14: 299-304. PMID 11371751 DOI: 10.1097/00019052-200106000-00006  0.52
2001 Flügel A, Berkowicz T, Ritter T, Labeur M, Jenne DE, Li Z, Ellwart JW, Willem M, Lassmann H, Wekerle H. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity. 14: 547-60. PMID 11371357 DOI: 10.1016/S1074-7613(01)00143-1  0.52
2001 Liblau R, Fontaine B, Baron-Van Evercooren A, Wekerle H, Lassmann H. Demyelinating diseases: from pathogenesis to repair strategies. Trends in Neurosciences. 24: 134-5. PMID 11294135 DOI: 10.1016/S0166-2236(00)01742-2  0.52
2001 Neuhaus O, Farina C, Wekerle H, Hohlfeld R. Mechanisms of action of glatiramer acetate in multiple sclerosis. Neurology. 56: 702-8. PMID 11288751  0.52
2001 Haase CG, Guggenmos J, Brehm U, Andersson M, Olsson T, Reindl M, Schneidewind JM, Zettl UK, Heidenreich F, Berger T, Wekerle H, Hohlfeld R, Linington C. The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls. Journal of Neuroimmunology. 114: 220-5. PMID 11240035 DOI: 10.1016/S0165-5728(00)00462-8  0.52
2001 Owens T, Wekerle H, Antel J. Genetic models for CNS inflammation. Nature Medicine. 7: 161-6. PMID 11175845 DOI: 10.1038/84603  0.52
2001 Flügel A, Matsumuro K, Neumann H, Klinkert WEF, Birnbacher R, Lassmann H, Otten U, Wekerle H. Enteric bacterial antigens activate CD4+ T cells from scid mice with inflammatory bowel disease European Journal of Immunology. 31: 23-31. PMID 11169434 DOI: 10.1002/1521-4141(200101)31:1<23::AID-IMMU23>3.0.CO;2-2  0.52
2001 Lassmann H, Wekerle H, Hickey WF, Antel J. GLIA: Editorial Glia. 36: 117. DOI: 10.1002/glia.1100  0.52
2000 Bourquin C, Iglesias A, Berger T, Wekerle H, Linington C. Myelin oligodendrocyte glycoprotein-DNA vaccination induces antibody-mediated autoaggression in experimental autoimmune encephalomyelitis. European Journal of Immunology. 30: 3663-71. PMID 11169409 DOI: 10.1002/1521-4141(200012)30:12<3663::AID-IMMU3663>3.0.CO;2-7  0.52
2000 Medana IM, Gallimore A, Oxenius A, Martinic MM, Wekerle H, Neumann H. MHC class I-restricted killing of neurons by virus-specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway,. European Journal of Immunology. 30: 3623-33. PMID 11169405 DOI: 10.1002/1521-4141(200012)30:12<3623::AID-IMMU3623>3.0.CO;2-F  0.52
2000 Litzenburger T, Blüthmann H, Morales P, Pham-Dinh D, Dautigny A, Wekerle H, Iglesias A. Development of myelin oligodendrocyte glycoprotein autoreactive transgenic B lymphocytes: receptor editing in vivo after encounter of a self-antigen distinct from myelin oligodendrocyte glycoprotein. Journal of Immunology (Baltimore, Md. : 1950). 165: 5360-6. PMID 11046072  0.52
2000 Flügel A, Schwaiger FW, Neumann H, Medana I, Willem M, Wekerle H, Kreutzberg GW, Graeber MB. Neuronal FasL induces cell death of encephalitogenic T lymphocytes. Brain Pathology (Zurich, Switzerland). 10: 353-64. PMID 10885654  0.52
2000 Neuhaus O, Farina C, Yassouridis A, Wiendl H, Then Bergh F, Dose T, Wekerle H, Hohlfeld R. Multiple sclerosis: comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 7452-7. PMID 10861011 DOI: 10.1073/pnas.97.13.7452  0.52
2000 Hohlfeld R, Kerschensteiner M, Stadelmann C, Lassmann H, Wekerle H. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. Journal of Neuroimmunology. 107: 161-6. PMID 10854651 DOI: 10.1016/S0165-5728(00)00233-2  0.52
2000 Goebels N, Hofstetter H, Schmidt S, Brunner C, Wekerle H, Hohlfeld R. Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence. Brain : a Journal of Neurology. 123: 508-18. PMID 10686174  0.52
1999 Padberg F, Matsuda M, Fenk R, Patenge N, Kubuschok B, Hohlfeld R, Wekerle H, Spuler S. Myasthenia gravis: selective enrichment of antiacetylcholine receptor antibody production in untransformed human B cell cultures. European Journal of Immunology. 29: 3538-48. PMID 10556808 DOI: 10.1002/(SICI)1521-4141(199911)29:11<3538::AID-IMMU3538>3.0.CO;2-Y  0.52
1999 Lindert RB, Haase CG, Brehm U, Linington C, Wekerle H, Hohlfeld R. Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain : a Journal of Neurology. 122: 2089-100. PMID 10545394 DOI: 10.1093/brain/122.11.2089  0.52
1999 Flügel A, Willem M, Berkowicz T, Wekerle H. Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nature Medicine. 5: 843-7. PMID 10395334 DOI: 10.1038/10567  0.52
1999 Bradl M, Bauer J, Inomata T, Zielasek J, Nave KA, Toyka K, Lassmann H, Wekerle H. Transgenic Lewis rats overexpressing the proteolipid protein gene: myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis. Acta Neuropathologica. 97: 595-606. PMID 10378378 DOI: 10.1007/s004010051035  0.52
1999 Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Misgeld T, Klinkert WE, Kolbeck R, Hoppe E, Oropeza-Wekerle RL, Bartke I, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld R. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? The Journal of Experimental Medicine. 189: 865-70. PMID 10049950 DOI: 10.1084/jem.189.5.865  0.52
1999 Wekerle H. Remembering MOG: autoantibody mediated demyelination in multiple sclerosis? Nature Medicine. 5: 153-4. PMID 9930860 DOI: 10.1038/5514  0.52
1998 Behrens L, Kerschensteiner M, Misgeld T, Goebels N, Wekerle H, Hohlfeld R. Human muscle cells express a functional costimulatory molecule distinct from B7.1 (CD80) and B7.2 (CD86) in vitro and in inflammatory lesions. Journal of Immunology (Baltimore, Md. : 1950). 161: 5943-51. PMID 9834075  0.52
1998 Wekerle H. Immune pathogenesis of multiple sclerosis. Brain autoimmune reactivity and its control by neuronal function. Multiple Sclerosis (Houndmills, Basingstoke, England). 4: 136-7. PMID 9762662  0.52
1998 Bauer J, Bradl M, Hickley WF, Forss-Petter S, Breitschopf H, Linington C, Wekerle H, Lassmann H. T-cell apoptosis in inflammatory brain lesions: destruction of T cells does not depend on antigen recognition. The American Journal of Pathology. 153: 715-24. PMID 9736022  0.52
1998 Zipp F, Kerschensteiner M, Dornmair K, Malotka J, Schmidt S, Bender A, Giegerich G, de Waal Malefyt R, Wekerle H, Hohlfeld R. Diversity of the anti-T-cell receptor immune response and its implications for T-cell vaccination therapy of multiple sclerosis. Brain : a Journal of Neurology. 121: 1395-407. PMID 9712003 DOI: 10.1093/brain/121.8.1395  0.52
1998 Wekerle H. The viral triggering of autoimmune disease. Nature Medicine. 4: 770-1. PMID 9662363 DOI: 10.1038/nm0798-770  0.52
1998 Litzenburger T, Fässler R, Bauer J, Lassmann H, Linington C, Wekerle H, Iglesias A. B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice. The Journal of Experimental Medicine. 188: 169-80. PMID 9653093 DOI: 10.1084/jem.188.1.169  0.52
1998 Kääb G, Haarmann I, Wekerle H, Bradl M. The myelin basic protein-specific T cell repertoire in Lewis rats: T cell receptor diversity is influenced both by intrathymic milieu and by extrathymic peptide presentation. European Journal of Immunology. 28: 1499-506. PMID 9603454 DOI: 10.1002/(SICI)1521-4141(199805)28:05<1499::AID-IMMU1499>3.0.CO;2-S  0.52
1998 Neumann H, Wekerle H. Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration. Journal of Neuropathology and Experimental Neurology. 57: 1-9. PMID 9600191  0.52
1998 Neumann H, Misgeld T, Matsumuro K, Wekerle H. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proceedings of the National Academy of Sciences of the United States of America. 95: 5779-84. PMID 9576961 DOI: 10.1073/pnas.95.10.5779  0.52
1998 Hinze-Selch D, Wetter TC, Zhang Y, Lu HC, Albert ED, Mullington J, Wekerle H, Holsboer F, Pollmächer T. In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls. Neurology. 50: 1149-52. PMID 9566413 DOI: 10.1212/WNL.50.4.1149  0.52
1997 Tourbah A, Linnington C, Bachelin C, Avellana-Adalid V, Wekerle H, Baron-Van Evercooren A. Inflammation promotes survival and migration of the CG4 oligodendrocyte progenitors transplanted in the spinal cord of both inflammatory and demyelinated EAE rats. Journal of Neuroscience Research. 50: 853-61. PMID 9418972 DOI: 10.1002/(SICI)1097-4547(19971201)50:5<853::AID-JNR21>3.0.CO;2-0  0.52
1997 Neumann H, Schmidt H, Wilharm E, Behrens L, Wekerle H. Interferon gamma gene expression in sensory neurons: evidence for autocrine gene regulation. The Journal of Experimental Medicine. 186: 2023-31. PMID 9396771 DOI: 10.1084/jem.186.12.2023  0.52
1997 Gehrmann J, Lannes-Vieira J, Wekerle H. Differential expression of fibroblast growth factor-2 and receptor by glial cells in experimental autoimmune encephalomelitis (EAE) Glia. 20: 86. PMID 9280753  0.52
1997 Schmidt S, Linington C, Zipp F, Sotgiu S, de Waal Malefyt R, Wekerle H, Hohlfeld R. Multiple sclerosis: comparison of the human T-cell response to S100 beta and myelin basic protein reveals parallels to rat experimental autoimmune panencephalitis. Brain : a Journal of Neurology. 120: 1437-45. PMID 9278633 DOI: 10.1093/brain/120.8.1437  0.52
1997 Kojima K, Wekerle H, Lassmann H, Berger T, Linington C. Induction of experimental autoimmune encephalomyelitis by CD4+ T cells specific for an astrocyte protein, S100 beta. Journal of Neural Transmission. Supplementum. 49: 43-51. PMID 9266413  0.52
1997 Kojima K, Reindl M, Lassmann H, Wekerle H, Linington C. The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus. International Immunology. 9: 897-904. PMID 9199973 DOI: 10.1093/intimm/9.6.897  0.52
1997 Meinl E, Fickenscher H, Hoch RM, Malefyt RD, de Waal Malefyt R, t Hart BA, Wekerle H, Hohlfeld R, Fleckenstein B. Growth transformation of antigen-specific T cell lines from rhesus monkeys by herpesvirus saimiri. Virology. 229: 175-82. PMID 9123859 DOI: 10.1006/viro.1996.8427  0.52
1997 Berger T, Weerth S, Kojima K, Linington C, Wekerle H, Lassmann H. Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system. Laboratory Investigation; a Journal of Technical Methods and Pathology. 76: 355-64. PMID 9121118  0.52
1997 Liu X, Linnington C, Webster HD, Lassmann S, Yao DL, Hudson LD, Wekerle H, Kreutzberg GW. Insulin-like growth factor-I treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis. Journal of Neuroscience Research. 47: 531-8. PMID 9067862 DOI: 10.1002/(SICI)1097-4547(19970301)47:5<531::AID-JNR8>3.0.CO;2-I  0.52
1997 Klinkert WE, Kojima K, Lesslauer W, Rinner W, Lassmann H, Wekerle H. TNF-alpha receptor fusion protein prevents experimental auto-immune encephalomyelitis and demyelination in Lewis rats: an overview. Journal of Neuroimmunology. 72: 163-8. PMID 9042109 DOI: 10.1016/S0165-5728(96)00183-X  0.52
1997 MeinL E, Hoch RM, Dornmair K, de Waal Malefyt R, Bontrop RE, Jonker M, Lassmann H, Hohlfeld R, Wekerle H, 't Hart BA. Encephalitogenic potential of myelin basic protein-specific T cells isolated from normal rhesus macaques. The American Journal of Pathology. 150: 445-53. PMID 9033260  0.52
1997 Neumann H, Schmidt H, Cavalié A, Jenne D, Wekerle H. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. The Journal of Experimental Medicine. 185: 305-16. PMID 9016879 DOI: 10.1084/jem.185.2.305  0.52
1997 Bradl M, Kaab G, Brandl G, Wekerle H. The myelin basic protein (MBP)-specific T cell response in Lewis rats: Thymic microenvironments and size of selecting peptides determine CD83 region composition and N nucleotide usage Immunobiology. 197: 134.  0.52
1997 Neumann H, Misgeld T, Matsumuro K, Wekerle H. Activity-dependent release of neurotropins inhibits MHC class II inducibility of microglia Immunobiology. 197: 246.  0.52
1997 Inomata T, Bauer J, Lassmann H, Wekerle H, Bradl M. T cell autoimmunity in the degenerating central nervous system (CNS) Immunobiology. 197: 240.  0.52
1997 Medana IM, Wekerle H, Neumann H. Interactions between cytotoxic T lymphocytes and MHC class I-induced neurons: A single cell analysis Immunobiology. 197: 411-412.  0.52
1996 Wekerle H, Bradl M, Linington C, Kääb G, Kojima K. The shaping of the brain-specific T lymphocyte repertoire in the thymus. Immunological Reviews. 149: 231-43. PMID 9005217  0.52
1996 Neumann H, Boucraut J, Hahnel C, Misgeld T, Wekerle H. Neuronal control of MHC class II inducibility in rat astrocytes and microglia. The European Journal of Neuroscience. 8: 2582-90. PMID 8996807 DOI: 10.1111/j.1460-9568.1996.tb01552.x  0.52
1996 Gehrmann J, Lannes-Vieira J, Wekerle H. Differential expression of fibroblast growth factor-2 and receptor by glial cells in experimental autoimmune encephalomyelitis (EAE) Glia. 16: 93-100. PMID 8929896 DOI: 10.1002/(SICI)1098-1136(199602)16:2<93::AID-GLIA1>3.0.CO;2-B  0.52
1996 Gold R, Schmied M, Tontsch U, Hartung HP, Wekerle H, Toyka KV, Lassmann H. Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death. A model for T-cell apoptosis in vivo. Brain : a Journal of Neurology. 119: 651-9. PMID 8800954 DOI: 10.1093/brain/119.2.651  0.52
1996 Goebels N, Michaelis D, Engelhardt M, Huber S, Bender A, Pongratz D, Johnson MA, Wekerle H, Tschopp J, Jenne D, Hohlfeld R. Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis. The Journal of Clinical Investigation. 97: 2905-10. PMID 8675705 DOI: 10.1172/JCI118749  0.52
1996 Kääb G, Brandl G, Marx A, Wekerle H, Bradl M. The myelin basic protein-specific T cell repertoire in (transgenic) Lewis rat/SCID mouse chimeras: preferential V beta 8.2 T cell receptor usage depends on an intact Lewis thymic microenvironment. European Journal of Immunology. 26: 981-8. PMID 8647189 DOI: 10.1002/eji.1830260504  0.52
1996 Spuler S, Sarropoulos A, Marx A, Hohlfeld R, Wekerle H. Thymoma-associated myasthenia gravis. Transplantation of thymoma and extrathymomal thymic tissue into SCID mice. The American Journal of Pathology. 148: 1359-65. PMID 8623907  0.52
1996 Wekerle H. Advances in neuroimmunology Clinical Neurology. 36: 1308.  0.52
1996 Cuzner ML, Wekerle H. Immunopathogenesis of demyelinating diseases: Introduction Brain Pathology. 6: 229-230.  0.52
1995 Wicker L, Wekerle H. Autoimmunity. Current Opinion in Immunology. 7: 783-5. PMID 8679120 DOI: 10.1016/0952-7915(95)80048-4  0.52
1995 Meinl E, Hohlfeld R, Wekerle H, Fleckenstein B. Immortalization of human T cells by Herpesvirus saimiri. Immunology Today. 16: 55-8. PMID 7888066 DOI: 10.1016/0167-5699(95)80087-5  0.52
1995 Bender A, Ernst N, Iglesias A, Dornmair K, Wekerle H, Hohlfeld R. T cell receptor repertoire in polymyositis: clonal expansion of autoaggressive CD8+ T cells. The Journal of Experimental Medicine. 181: 1863-8. PMID 7722460  0.52
1995 Neumann H, Cavalié A, Jenne DE, Wekerle H. Induction of MHC class I genes in neurons. Science (New York, N.Y.). 269: 549-52. PMID 7624779  0.52
1995 Banati RB, Gehrmann J, Lannes-Vieira J, Wekerle H, Kreutzberg GW. Inflammatory reaction in experimental autoimmune encephalomyelitis (EAE) is accompanied by a microglial expression of the beta A4-amyloid precursor protein (APP). Glia. 14: 209-15. PMID 7591032 DOI: 10.1002/glia.440140306  0.52
1995 Kramer R, Zhang Y, Gehrmann J, Gold R, Thoenen H, Wekerle H. Gene transfer through the blood-nerve barrier: NGF-engineered neuritogenic T lymphocytes attenuate experimental autoimmune neuritis. Nature Medicine. 1: 1162-6. PMID 7584988  0.52
1995 Gehrmann J, Yao DL, Bonetti B, Brenner M, Bondy C, Wekerle H, Kreutzberg GW, Webster Hde F. Astrocytes upregulate glial fibrillary acidic protein (GFAP), but not insulin-like growth factor-I (IGF-I) during experimental autoimmune neuritis (EAN). Brain Pathology (Zurich, Switzerland). 5: 1-10. PMID 7539325  0.52
1995 Lannes-Viera J, Goudable B, Drexler K, Gehrmann J, Torres-Nagel N, Hünig T, Wekerle H. Encephalitogenic, myelin basic protein-specific T cells from naive rat thymus: preferential use of the T cell receptor gene V beta 8.2 and expression of the CD4-CD8- phenotype. European Journal of Immunology. 25: 611-6. PMID 7533094 DOI: 10.1002/eji.1830250245  0.52
1995 Meinl E, t Hart BA, Bontrop RE, Hoch RM, Iglesias A, de Waal Malefyt R, Fickenscher H, Müller-Fleckenstein I, Fleckenstein B, Wekerle H. Activation of a myelin basic protein-specific human T cell clone by antigen-presenting cells from rhesus monkeys. International Immunology. 7: 1489-95. PMID 7495756 DOI: 10.1093/intimm/7.9.1489  0.52
1995 Zipp F, Weber F, Huber S, Sotgiu S, Czlonkowska A, Holler E, Albert E, Weiss EH, Wekerle H, Hohlfeld R. Genetic control of multiple sclerosis: increased production of lymphotoxin and tumor necrosis factor-alpha by HLA-DR2+ T cells. Annals of Neurology. 38: 723-30. PMID 7486863 DOI: 10.1002/ana.410380506  0.52
1994 Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baeuerle PA. Constitutive NF-kappa B activity in neurons. Molecular and Cellular Biology. 14: 3981-92. PMID 8196637  0.52
1994 Wekerle H, Lassmann H. Contra: evidence against a primary lesion in the target organ in autoimmune disease. International Archives of Allergy and Immunology. 103: 328-31. PMID 8130647 DOI: 10.1159/000236650  0.52
1994 Hohlfeld R, Wekerle H. The thymus in myasthenia gravis. Neurologic Clinics. 12: 331-42. PMID 8041345  0.52
1994 Kaltschmidt C, Kaltschmidt B, Lannes-Vieira J, Kreutzberg GW, Wekerle H, Baeuerle PA, Gehrmann J. Transcription factor NF-kappa B is activated in microglia during experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 55: 99-106. PMID 7962486 DOI: 10.1016/0165-5728(94)90151-1  0.52
1994 Stöckel J, Meinl E, Hahnel C, Malotka J, Seitz R, Drexler K, Wekerle H, Dornmair K. Refolding of human class II major histocompatibility complex molecules isolated from Escherichia coli. Assembly of peptide-free heterodimers and increased refolding-yield in the presence of antigenic peptide. The Journal of Biological Chemistry. 269: 29571-8. PMID 7961943  0.52
1994 Spuler S, Marx A, Kirchner T, Hohlfeld R, Wekerle H. Myogenesis in thymic transplants in the severe combined immunodeficient mouse model of myasthenia gravis. Differentiation of thymic myoid cells into striated muscle cells. The American Journal of Pathology. 145: 766-70. PMID 7943168  0.52
1994 Meinl E, Aloisi F, Ertl B, Weber F, de Waal Malefyt R, Wekerle H, Hohlfeld R. Multiple sclerosis. Immunomodulatory effects of human astrocytes on T cells. Brain : a Journal of Neurology. 117: 1323-32. PMID 7820569  0.52
1994 Pilat D, Fink T, Obermaier-Skrobanek B, Zimmer M, Wekerle H, Lichter P, Jenne DE. The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. Genomics. 24: 445-50. PMID 7713495 DOI: 10.1006/geno.1994.1651  0.52
1994 Hohlfeld R, Wekerle H. The role of the thymus in myasthenia gravis. Advances in Neuroimmunology. 4: 373-86. PMID 7536601 DOI: 10.1016/0960-5428(94)00040-U  0.52
1994 Engelhardt B, Görlach H, Risau W, Wekerle H. Lysis of rat brain microvascular endothelial cells mediated by resting but not activated MBP-specific CD4+ T cell lines. Journal of Neuroimmunology. 55: 69-80. PMID 7525644 DOI: 10.1016/0165-5728(94)90148-1  0.52
1994 Kojima K, Berger T, Lassmann H, Hinze-Selch D, Zhang Y, Gehrmann J, Reske K, Wekerle H, Linington C. Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of astroglia. The Journal of Experimental Medicine. 180: 817-29. PMID 7520474 DOI: 10.1084/jem.180.3.817  0.52
1994 Lannes-Vieira J, Gehrmann J, Kreutzberg GW, Wekerle H. The inflammatory lesion of T cell line transferred experimental autoimmune encephalomyelitis of the Lewis rat: distinct nature of parenchymal and perivascular infiltrates. Acta Neuropathologica. 87: 435-42. PMID 7520206 DOI: 10.1007/BF00294169  0.52
1994 Wekerle H, Kojima K, Lannes-Vieira J, Lassmann H, Linington C. Animal models. Annals of Neurology. 36: S47-53. PMID 7517126 DOI: 10.1002/ana.410360714  0.52
1994 Weber F, Meinl E, Aloisi F, Nevinny-Stickel C, Albert E, Wekerle H, Hohlfeld R. Human astrocytes are only partially competent antigen presenting cells. Possible implications for lesion development in multiple sclerosis. Brain : a Journal of Neurology. 117: 59-69. PMID 7511974  0.52
1993 Gold R, Schmied M, Rothe G, Zischler H, Breitschopf H, Wekerle H, Lassmann H. Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 41: 1023-30. PMID 8515045  0.52
1993 Wekerle H. T-cell autoimmunity in the central nervous system. Intervirology. 35: 95-100. PMID 8407255 DOI: 10.1159/000150299  0.52
1993 Gehrmann J, Gold R, Linington C, Lannes-Vieira J, Wekerle H, Kreutzberg GW. Microglial involvement in experimental autoimmune inflammation of the central and peripheral nervous system. Glia. 7: 50-9. PMID 8380791 DOI: 10.1002/glia.440070110  0.52
1993 Salvetti M, Buttinelli C, Massacesi L, Wekerle H. New approaches to the study of T cell autoimmunity in multiple sclerosis. Meeting report on the 2nd Workshop on T cell Autoimmunity in MS, Perugia, Italy, 26-28 November, 1992. Journal of Neuroimmunology. 47: 203-5. PMID 8370772 DOI: 10.1016/0165-5728(93)90031-S  0.52
1993 Schönbeck S, Padberg F, Marx A, Hohlfeld R, Wekerle H. Transplantation of myasthenia gravis thymus to SCID mice. Annals of the New York Academy of Sciences. 681: 66-73. PMID 8357210  0.52
1993 Wekerle H. The thymus in myasthenia gravis. Annals of the New York Academy of Sciences. 681: 47-55. PMID 8357188 DOI: 10.1111/j.1749-6632.1993.tb22868.x  0.52
1993 Schmied M, Breitschopf H, Gold R, Zischler H, Rothe G, Wekerle H, Lassmann H. Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. The American Journal of Pathology. 143: 446-52. PMID 8342595  0.52
1993 Fink TM, Lichter P, Wekerle H, Zimmer M, Jenne DE. The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily. Genomics. 18: 401-3. PMID 8288245 DOI: 10.1006/geno.1993.1483  0.52
1993 Wekerle H. Experimental autoimmune encephalomyelitis as a model of immune-mediated CNS disease. Current Opinion in Neurobiology. 3: 779-84. PMID 8260829 DOI: 10.1016/0959-4388(93)90153-P  0.52
1993 Linington C, Berger T, Perry L, Weerth S, Hinze-Selch D, Zhang Y, Lu HC, Lassmann H, Wekerle H. T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system. European Journal of Immunology. 23: 1364-72. PMID 7684687 DOI: 10.1002/eji.1830230627  0.52
1993 Salvetti M, Ristori G, D'Amato M, Buttinelli C, Falcone M, Fieschi C, Wekerle H, Pozzilli C. Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis. European Journal of Immunology. 23: 1232-9. PMID 7684682 DOI: 10.1002/eji.1830230606  0.52
1993 Melms A, Weissert R, Klinkert WE, Schalke BC, Tzartos S, Wekerle H. Specific immune complexes augment in vitro acetylcholine receptor-specific T-cell proliferation. Neurology. 43: 583-8. PMID 7680803  0.52
1993 Saruhan-Direskeneli G, Weber F, Meinl E, Pette M, Giegerich G, Hinkkanen A, Epplen JT, Hohlfeld R, Wekerle H. Human T cell autoimmunity against myelin basic protein: CD4+ cells recognizing epitopes of the T cell receptor beta chain from a myelin basic protein-specific T cell clone. European Journal of Immunology. 23: 530-6. PMID 7679649 DOI: 10.1002/eji.1830230235  0.52
1993 Hinkkanen AE, Määttä J, Qin YF, Linington C, Salmi A, Wekerle H. Novel Tcr Tcra-V and -J transcripts expressed in rat myelin-specific T-cell lines. Immunogenetics. 37: 235-8. PMID 7678406 DOI: 10.1007/BF00191892  0.52
1993 Kiefer R, Gold R, Gehrmann J, Lindholm D, Wekerle H, Kreutzberg GW. Transforming growth factor beta expression in reactive spinal cord microglia and meningeal inflammatory cells during experimental allergic neuritis. Journal of Neuroscience Research. 36: 391-8. PMID 7505838 DOI: 10.1002/jnr.490360405  0.52
1993 Meinl E, Weber F, Drexler K, Morelle C, Ott M, Saruhan-Direskeneli G, Goebels N, Ertl B, Jechart G, Giegerich G, Schönbeck S, Bannwarth W, Wekerle H, Hohlfeld R. Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis: Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones Journal of Clinical Investigation. 92: 2633-2643. PMID 7504690  0.52
1993 Weber F, Meinl E, Drexler K, Czlonkowska A, Huber S, Fickenscher H, Müller-Fleckenstein I, Fleckenstein B, Wekerle H, Hohlfeld R. Transformation of human T-cell clones by Herpesvirus saimiri: intact antigen recognition by autonomously growing myelin basic protein-specific T cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 11049-53. PMID 7504291  0.52
1992 Gehrmann J, Gold R, Linington C, Lannes-Vieira J, Wekerle H, Kreutzberg GW. Spinal cord microglia in experimental allergic neuritis. Evidence for fast and remote activation. Laboratory Investigation; a Journal of Technical Methods and Pathology. 67: 100-13. PMID 1625441  0.52
1992 Giegerich G, Pette M, Meinl E, Epplen JT, Wekerle H, Hinkkanen A. Diversity of T cell receptor alpha and beta chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes. European Journal of Immunology. 22: 753-8. PMID 1372258 DOI: 10.1002/eji.1830220319  0.52
1991 Sun D, Wekerle H, Raper K, Gold DP. CD4-CD8- splenic T cells from Lewis rats recovered from experimental autoimmune encephalomyelitis respond to encephalitogenic T cells that mediate this disorder. Cellular Immunology. 137: 292-302. PMID 1909933 DOI: 10.1016/0008-8749(91)90080-U  0.52
1991 Wekerle H. Immunopathogenesis of multiple sclerosis. Acta Neurologica. 13: 197-204. PMID 1891986  0.52
1990 Pette M, Fujita K, Wilkinson D, Altmann DM, Trowsdale J, Giegerich G, Hinkkanen A, Epplen JT, Kappos L, Wekerle H. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proceedings of the National Academy of Sciences of the United States of America. 87: 7968-72. PMID 1700423  0.52
1990 Giegerich G, Pette M, Fujita K, Wekerle H, Epplen JT, Hinkkanen A. Rapid method based on reversed-phase high-performance liquid chromatography for purification of human myelin basic protein and its thrombic and endoproteinase Lys-C peptides. Journal of Chromatography. 528: 79-90. PMID 1696585 DOI: 10.1016/S0378-4347(00)82364-6  0.52
1989 Melms A, Chrestel S, Schalke BC, Wekerle H, Mauron A, Ballivet M, Barkas T. Autoimmune T lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene. The Journal of Clinical Investigation. 83: 785-90. PMID 2466050 DOI: 10.1172/JCI113958  0.52
1988 Kitze B, Pette M, Rohrbach E, Städt D, Kappos L, Wekerle H. Myelin-specific T lymphocytes in multiple sclerosis patients and healthy individuals. Journal of Neuroimmunology. 20: 237. PMID 2461957  0.52
1986 Linington C, Wekerle H, Meyermann R. T lymphocyte autoimmunity in peripheral nervous system autoimmune disease. Agents and Actions. 19: 256-65. PMID 2435116  0.4
1986 Wekerle H, Schwab M, Linington C, Meyermann R. Antigen presentation in the peripheral nervous system: Schwann cells present endogenous myelin autoantigens to lymphocytes. European Journal of Immunology. 16: 1551-7. PMID 2434335 DOI: 10.1002/eji.1830161214  0.4
1986 Linington C, Mann A, Izumo S, Uyemura K, Suzuki M, Meyermann R, Wekerle H. Induction of experimental allergic neuritis in the BN rat: P2 protein-specific T cells overcome resistance to actively induced disease. Journal of Immunology (Baltimore, Md. : 1950). 137: 3826-31. PMID 2431045  0.52
1986 Heininger K, Stoll G, Linington C, Toyka KV, Wekerle H. Conduction failure and nerve conduction slowing in experimental allergic neuritis induced by P2-specific T-cell lines. Annals of Neurology. 19: 44-9. PMID 2418761 DOI: 10.1002/ana.410190109  0.4
1985 Schalke BC, Klinkert WE, Wekerle H, Dwyer DS. Enhanced activation of a T cell line specific for acetylcholine receptor (AChR) by using anti-AChR monoclonal antibodies plus receptors. Journal of Immunology (Baltimore, Md. : 1950). 134: 3643-8. PMID 2580892  0.52
1985 Izumo S, Linington C, Wekerle H, Meyermann R. Morphologic study on experimental allergic neuritis mediated by T cell line specific for bovine P2 protein in Lewis rats. Laboratory Investigation; a Journal of Technical Methods and Pathology. 53: 209-18. PMID 2410663  0.4
1984 Linington C, Izumo S, Suzuki M, Uyemura K, Meyermann R, Wekerle H. A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo. Journal of Immunology (Baltimore, Md. : 1950). 133: 1946-50. PMID 6206142  0.52
1977 Koszinowski U, Ertl H, Wekerle H, Thomssen R. Recognition of alterations induced by early vaccinia surface antigens and dependence of virus-specific lysis on H-2 antigen concentration on target cells. Cold Spring Harbor Symposia On Quantitative Biology. 41: 529-37. PMID 302176  0.52
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