| Year |
Citation |
Score |
| 2018 |
Park SY, Kim JY, Choi JH, Kim JH, Lee CJ, Singh P, Sarkar S, Baek JH, Nam JS. Inhibition of LEF1-mediated DCLK1 by Niclosamide Attenuates Colorectal Cancer Stemness. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30446587 DOI: 10.1158/1078-0432.Ccr-18-1232 |
0.42 |
|
| 2017 |
Sarkar S, O'Connell MR, Okugawa Y, Lee BS, Toiyama Y, Kusunoki M, Daboval RD, Goel A, Singh P. FOXD3 Regulates CSC Marker, DCLK1-S, and Invasive Potential: Prognostic Implications in Colon Cancer. Molecular Cancer Research : McR. PMID 28851816 DOI: 10.1158/1541-7786.Mcr-17-0287 |
0.372 |
|
| 2017 |
Sarkar S, Popov VL, O'Connell MR, Stevenson HL, Lee BS, Obeid RA, Luthra GK, Singh P. A novel antibody against cancer stem cell biomarker, DCLK1-S, is potentially useful for assessing colon cancer risk after screening colonoscopy. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 28414327 DOI: 10.1038/Labinvest.2017.40 |
0.362 |
|
| 2017 |
Connell MO, Sarkar S, Spratt H, Widen S, Wood TG, Singh P. Abstract 902: Cancer-stem-cell (CSC) marker, DCLK1-S, enhances invasive potential of cancer cells by phosphorylating/activating NFATc2: role of COL3A1 and SPARC in mediating metastatic effects of DCLK1-S/NFATc2 Cancer Research. 77: 902-902. DOI: 10.1158/1538-7445.Am2017-902 |
0.442 |
|
| 2017 |
Sarkar S, Popov VLL, O'Connell M, Stevenson HL, Lee BS, Obeid RA, Singh P. Abstract 729: A novel cancer-stem-cell biomarker, DCLK1-S, traffics to nuclei of colon cancer cells: potential use as a biomarker for assessing colon cancer risk after screening colonoscopy Cancer Research. 77: 729-729. DOI: 10.1158/1538-7445.Am2017-729 |
0.413 |
|
| 2016 |
Singh P, O'Connell M, Shubhashish S. Epigenetic regulation of human DCLK-1 gene during colon-carcinogenesis: clinical and mechanistic implications. Stem Cell Investigation. 3: 51. PMID 27777940 DOI: 10.21037/Sci.2016.09.07 |
0.358 |
|
| 2016 |
Sarkar S, Connell MO, Singh P. Abstract 5242: Differential, dose-dependent, effects of curcumin/analogs, on long (L) versus short (S) isoforms of a cancer stem cell marker, DCLK1, in colon and pancreatic cancer cells: biological impact Cancer Research. 76: 5242-5242. DOI: 10.1158/1538-7445.Am2016-5242 |
0.462 |
|
| 2016 |
Sarkar S, Connell MO, Popov VL, Luthra G, Singh P. Abstract 2957: Generation of a novel, mono-specific, antibody against short Isoform of DCLK1 (DCLK1-S): a novel biomarker of colon carcinogenesis in patients Cancer Research. 76: 2957-2957. DOI: 10.1158/1538-7445.Am2016-2957 |
0.357 |
|
| 2016 |
O’Connell MR, Sarkar S, Luthra G, Okugawa Y, Toiyama Y, Ward D, Goel A, Singh P. Abstract 2892: FOXD3 is a novel repressor of the expression of short isoform of DCLK1 (DCLK1-S) from IntronV(β)-promoter of hDCLK1-gene, and is epigenetically silenced in hCRCs: prognostic/diagnostic implications of FOXD3/DCLK1-S expression in hCRCs Cancer Research. 76: 2892-2892. DOI: 10.1158/1538-7445.Am2016-2892 |
0.376 |
|
| 2016 |
Sarkar S, O'Connell MR, Singh P. Su2058 Curcumin and its Bioavailable Analog (EF24), Differentially Regulate Expression of Long (L) Versus Short (S) Isoforms of DCLK1 in Human Cancer (Colon/Pancreatic) Cells, Dose-Dependently, In Vitro and In Vivo Gastroenterology. 150: S623-S624. DOI: 10.1016/S0016-5085(16)32140-0 |
0.395 |
|
| 2016 |
O'Connell MR, Sarkar S, Luthra G, Okugawa Y, Toiyama Y, Ward D, Goel A, Singh P. Su1996 FOXD3 Is a Novel Negative Regulator of Intronv(β)-Promoter Within hDCLK1-Gene in Normal Colonic Cells, But Gets Epigenetically Silenced in hCRCs, Resulting in the Expression of a Short Isoform of DCLK1 (DCLK1-S): Prognostic/Diagnostic Implications of FOXD3/DCLK1-S Expression in hCRCs Gastroenterology. 150: S605. DOI: 10.1016/S0016-5085(16)32078-9 |
0.333 |
|
| 2016 |
O'Connell MR, Sarkar S, Ward D, Singh P. Su1995 Short (S) Isoform of Cancer-Stem-Cell Marker, DCLK1, Is Critically Required for Maintaining Proliferative/Tumorigenic Potential of Human Colon Cancer Cells (hCCCs) Independent of DCLK1-L Isoform Gastroenterology. 150: S605. DOI: 10.1016/S0016-5085(16)32077-7 |
0.451 |
|
| 2015 |
Huynh PT, Beswick EJ, Coronado YA, Johnson P, O'Connell MR, Watts T, Singh P, Qiu S, Morris K, Powell DW, Pinchuk IV. CD90(+) stromal cells are the major source of IL-6 which supports cancer stem-like cells and inflammation in colorectal cancer. International Journal of Cancer. Journal International Du Cancer. PMID 26595254 DOI: 10.1002/Ijc.29939 |
0.385 |
|
| 2015 |
O'Connell MR, Sarkar S, Luthra GK, Okugawa Y, Toiyama Y, Gajjar AH, Qiu S, Goel A, Singh P. Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications. Scientific Reports. 5: 14983. PMID 26447334 DOI: 10.1038/Srep14983 |
0.426 |
|
| 2015 |
Kantara C, Moya SM, Houchen CW, Umar S, Ullrich RL, Singh P, Carney DH. Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 26280221 DOI: 10.1038/Labinvest.2015.103 |
0.736 |
|
| 2015 |
Kantara C, O'Connell MR, Luthra G, Gajjar A, Sarkar S, Ullrich RL, Singh P. Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis. Laboratory Investigation; a Journal of Technical Methods and Pathology. 95: 100-12. PMID 25347154 DOI: 10.1038/Labinvest.2014.133 |
0.768 |
|
| 2015 |
O'Connell MR, Sarkar S, Luthra G, Okugawa Y, Toiyama Y, Goel A, Gajjar A, Qiu S, Sowers L, Singh P. Abstract 543: A short isoform of DCLK1, transcribed from an alternate promoter in human colon cancers, represents a novel biomarker and target for diagnostic and treatment purposes Cancer Research. 75: 543-543. DOI: 10.1158/1538-7445.Am2015-543 |
0.471 |
|
| 2015 |
Sarkar S, O'Connell M, singh P. Abstract 2817: Dietary chemopreventive agent (curcumin), hypomethylates 5′ promoter of DCLK1 gene in human colon cancer cells and restores expression of long isoform of DCLK1 Cancer Research. 75: 2817-2817. DOI: 10.1158/1538-7445.Am2015-2817 |
0.389 |
|
| 2015 |
Kantara C, O'Connell MR, Luthra G, Gajjar A, Sarkar S, Ullrich RL, Singh P. Inside the USCAP Journals Laboratory Investigation. 95: 2-3. DOI: 10.1038/Labinvest.2014.152 |
0.681 |
|
| 2015 |
O'Connell MR, Sarkar S, Luthra G, Okugawa Y, Toiyama Y, Goel A, Gajjar A, Qiu S, Sowers L, Singh P. 60 A Short Isoform of DCLK1 Is a Novel Prognostic Marker for Human Colon Cancers, and Can Be Used As a Specific Target for Preventing and/or Treating Colon Cancers, While Sparing Normal Cells Gastroenterology. 148: S-18. DOI: 10.1016/S0016-5085(15)30060-3 |
0.418 |
|
| 2014 |
Andey T, Marepally S, Patel A, Jackson T, Sarkar S, O'Connell M, Reddy RC, Chellappan S, Singh P, Singh M. Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model. Journal of Controlled Release : Official Journal of the Controlled Release Society. 184: 67-78. PMID 24727000 DOI: 10.1016/J.Jconrel.2014.03.049 |
0.419 |
|
| 2014 |
Kantara C, O'Connell M, Sarkar S, Moya S, Ullrich R, Singh P. Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA. Cancer Research. 74: 2487-98. PMID 24626093 DOI: 10.1158/0008-5472.Can-13-3536 |
0.789 |
|
| 2014 |
Sarkar S, O'Connell M, Kantara C, Singh P. Abstract 3903: A sub-set of DCLK1+vecolon cancer stem cells (CSCs) survive curcumin induced autophagy, while co-treatment with curcumin +DCLK1-siRNA eliminates CSCs: Role of long and short isofoms of DCLK1 Cancer Research. 74: 3903-3903. DOI: 10.1158/1538-7445.Am2014-3903 |
0.799 |
|
| 2014 |
O'Connell MR, Sarkar S, Singh P. Abstract 1940: Short (S) isoform of cancer-stem-cell marker, DCLK1, is critically required to maintain proliferative/tumorigenic potential of colon cancer cells: identification of associated molecular pathways Cancer Research. 74: 1940-1940. DOI: 10.1158/1538-7445.Am2014-1940 |
0.457 |
|
| 2014 |
Sarkar S, O'Connell MR, Luthra G, Singh P. Su1991 Progastrin Up-Regulates the Expression of Both Long and Short Isoforms of Cancer Stem Cell Marker, DCLK1, by Transcriptionally Activating Their Respective Promoters: Role of β-Catenin and NfκB Response Elements Gastroenterology. 146: S-516. DOI: 10.1016/S0016-5085(14)61870-9 |
0.402 |
|
| 2014 |
O'Connell MR, Sarkar S, Kantara C, Singh P. Sa1959 Curcumin Induces Autophagic Survival of DCLK1+VE Colon Cancer Stem Cells (CSCs), While Co-Treatment With Curcumin and DCLK1-siRNA Eliminates CSCS: Role of Long and Short Isofoms of DCLK1 Gastroenterology. 146: S-340. DOI: 10.1016/S0016-5085(14)61229-4 |
0.773 |
|
| 2013 |
O'Connell MR, Sarkar S, Luthra G, Qui S, Gajjar A, Maxwell C, Singh P. Abstract 4891: The short isoform of stem-cell-marker DCLK1(DCLK1-S) is strongly up-regulated during adenoma-carcinoma sequence of coloncancer disease: Role of autocrine/endocrine progastrin. Cancer Research. 73: 4891-4891. DOI: 10.1158/1538-7445.Am2013-4891 |
0.454 |
|
| 2013 |
Andey TA, Marepally S, Singh P, Sachdeva MS. Abstract 3738: Knockdown of Annexin A2 by liposomal formulation of Annexin A2 small hairpin RNA induces apoptosis and inhibits angiogenesis in lung cancer stem cells. Cancer Research. 73: 3738-3738. DOI: 10.1158/1538-7445.Am2013-3738 |
0.416 |
|
| 2013 |
Sarkar S, Connell MO, Moya SM, Singh P. Abstract 2574: Curcumin either stimulates or inhibits expression of short isoform of stem-cell-marker DCLK1 (DCLK1-S) in non-transformed vs transformed cells, resulting in stabilization/inhibition of growth, respectively. Cancer Research. 73: 2574-2574. DOI: 10.1158/1538-7445.Am2013-2574 |
0.459 |
|
| 2013 |
Sarkar S, O'Connell MR, Moya S, Singh P. Mo1166 Opposite Effects of Curcumin on the Expression of Short (S) Form of Stem-Cell-Marker, DCLK1, in Non-Transformed vs Transformed Cells Resulting in Either Stabilization or Inhibition of Cell Proliferation Respectively Gastroenterology. 144: S-596. DOI: 10.1016/S0016-5085(13)62199-X |
0.408 |
|
| 2013 |
O'Connell MR, Sarkar S, Luthra G, Qiu S, Gajjar A, Maxwell CA, Singh P. Sa1727 The Short (S) Isoform of Stem-Cell-Marker DCLK1 Is Increasingly Up-Regulated During Colon Carcinogensis: Role of Autocrine/Endocrine Progastrin Gastroenterology. 144: S-293. DOI: 10.1016/S0016-5085(13)61039-2 |
0.411 |
|
| 2012 |
Singh P, Sarkar S, Kantara C, Maxwell C. Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells. Current Colorectal Cancer Reports. 8: 277-289. PMID 23226720 DOI: 10.1007/S11888-012-0144-3 |
0.783 |
|
| 2012 |
Sarkar S, Kantara C, Ortiz I, Swiercz R, Kuo J, Davey R, Escobar K, Ullrich R, Singh P. Progastrin overexpression imparts tumorigenic/metastatic potential to embryonic epithelial cells: phenotypic differences between transformed and nontransformed stem cells. International Journal of Cancer. Journal International Du Cancer. 131: E1088-99. PMID 22532325 DOI: 10.1002/Ijc.27615 |
0.786 |
|
| 2012 |
Sarkar S, Kantara C, Singh P. Clathrin mediates endocytosis of progastrin and activates MAPKs: role of cell surface annexin A2. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G712-22. PMID 22241862 DOI: 10.1152/Ajpgi.00406.2011 |
0.769 |
|
| 2012 |
Kantara C, Sarkar S, Maxwell C, Ullrich R, Singh P. Abstract 2378: Detection of circulating tumors cells (CTCs) in mice, using cancer stem cell (CSC) markers and a novel cell surface marker, AnnexinA2 Cancer Research. 72: 2378-2378. DOI: 10.1158/1538-7445.Am2012-2378 |
0.784 |
|
| 2012 |
Sarkar S, Kantara C, Singh P. Mo1643 Clathrin Mediates Endocytosis of Progastrin (PG) and Activates MAPKs; Role of Cell-Surface Associated Annexina2(Cs-Anxa2) Gastroenterology. 142: S-648. DOI: 10.1016/S0016-5085(12)62498-6 |
0.734 |
|
| 2012 |
Kantara C, Ortiz I, Singh P. Sa1810 Targeting Caner Stem Cells (CSCs) With CurcuminRNAI Against Stem-Cell Markers, In Vitro and In Vivo: Effect on Oncogenic-Pathways Gastroenterology. 142: S-331. DOI: 10.1016/S0016-5085(12)61247-5 |
0.764 |
|
| 2012 |
Kantara C, Sarkar S, Maxwell CA, Ullrich R, Singh P. 405 Circulating Tumors Cells (Ctcs), Positive for Cancer-Stem-Cell (CSC) Markers and Cell-Surface Annexina2, are Significantly Increased in Mice Bearing Metastatic Versus Primary Colon Cancer Tumors Gastroenterology. 142: S-89. DOI: 10.1016/S0016-5085(12)60341-2 |
0.791 |
|
| 2011 |
Sarkar S, Swiercz R, Kantara C, Hajjar KA, Singh P. Annexin A2 mediates up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells. Gastroenterology. 140: 583-595.e4. PMID 20826156 DOI: 10.1053/J.Gastro.2010.08.054 |
0.743 |
|
| 2011 |
Kantara C, Sarkar S, Swiercz R, Ullrich R, Singh P. Abstract 4363: Inhibitory efficacy of curcumin ± stem cell specific RNAi on the growth of tumorospheres in vitro: Assay development and mechanisms of action Cancer Research. 71: 4363-4363. DOI: 10.1158/1538-7445.Am2011-4363 |
0.788 |
|
| 2011 |
Sarkar S, Maxwell CA, Luthra G, Singal A, Qiu S, Bauer VP, Okorodudu AO, Singh P. Annexina2 is Increasingly Expressed and Released Into the Serum of Patients Positive for Colonic Growths/Tumors in Relation to Disease Progression: Diagnostic Implications Gastroenterology. 140: S-341. DOI: 10.1016/S0016-5085(11)61385-1 |
0.412 |
|
| 2011 |
Kantara C, Sarkar S, Swiercz R, Ortiz I, Singh P. Overexpression of Progastrin Imparts Tumorigenic/Metastatic Potential to Immortalized Embryonic Cells and Cancer Cells: Role of Stem/Progenitor Cell Markers and AnnexinA2 Gastroenterology. 140: S-48. DOI: 10.1016/S0016-5085(11)60192-3 |
0.784 |
|
| 2010 |
Singh P, Sarkar S, Umar S, Rengifo-Cam W, Singh AP, Wood TG. Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK. American Journal of Physiology. Gastrointestinal and Liver Physiology. 298: G551-62. PMID 20133951 DOI: 10.1152/Ajpgi.00497.2009 |
0.345 |
|
| 2010 |
Sarkar S, May R, Kantara C, Houchen C, Shahid U, Singh P. Abstract 4259: Over-expression of autocrine progastrin up-regulates DCAMKL+1/CD44 positive stem/progenitor cells, associated with surprising transformation of HEK-293 cells,in vitroandin vivo Cancer Research. 70: 4259-4259. DOI: 10.1158/1538-7445.Am10-4259 |
0.804 |
|
| 2010 |
Singh P, Sarkar S. Abstract 2585: Targeting extra-cellular Annexin2 on epithelial cancer cells with labeled ligands for diagnosis/treatment of cancers Cancer Research. 70: 2585-2585. DOI: 10.1158/1538-7445.Am10-2585 |
0.389 |
|
| 2010 |
Sarkar S, Kantara C, Houchen CW, Umar S, Singh P. W1890 Dcamkl+1 and CD44 Positive Stem/Progenitor Cells are Significantly up-Regulated in Response to Autocrine Progastrin Expression, Associated With Surprising Transformation of Hek-293 Cells, In Vitro and In Vivo Gastroenterology. 138: S-760. DOI: 10.1016/S0016-5085(10)63503-2 |
0.769 |
|
| 2010 |
Singh P, Sarkar S. T1152 Novel use of Progastrin Binding to Extracellular Annexin2 on Epithelial Cancer Cells for Diagnosis/Treatment of GI Cancers Gastroenterology. 138: S-499. DOI: 10.1016/S0016-5085(10)62307-4 |
0.368 |
|
| 2009 |
Umar S, Sarkar S, Wang Y, Singh P. Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin. The Journal of Biological Chemistry. 284: 22274-84. PMID 19497850 DOI: 10.1074/Jbc.M109.020941 |
0.346 |
|
| 2008 |
Umar S, Sarkar S, Cowey S, Singh P. Activation of NF-kappaB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo. Oncogene. 27: 5599-611. PMID 18521082 DOI: 10.1038/Onc.2008.169 |
0.421 |
|
| 2008 |
Umar S, Singh P. S2003 Synergistic Effects of Progastrin (PG) and Citrobacter Rodentium (CR) On the Growth of Proximal and Distal Colonic Epithelial Cells in FVB/N Mice: Associated Changes in the Levels of β-Catenin, NF-κB and ERK1/2 Gastroenterology. 134: A-295. DOI: 10.1016/S0016-5085(08)61373-6 |
0.375 |
|
| 2008 |
Sarkar S, Singh P. S1694 Annexin-II Mediates Potent Growth Factor Effects of Full Length Progastrin On Human Embryonic Kidney Cells (HEK293): Activation of NFkB/β-Catenin and Up-Regulation of Target Gene Proteins Gastroenterology. 134: A-251. DOI: 10.1016/S0016-5085(08)61165-8 |
0.33 |
|
| 2008 |
Sarkar S, Singh P. S1669 Expression of Progastrin/Gastrin Receptor, Annexin-II, Is Required for Binding and Internalization of PG in Intestinal Epithelial Cells (IEC-18): Functional Correlates Gastroenterology. 134: A-246. DOI: 10.1016/S0016-5085(08)61140-3 |
0.344 |
|
| 2008 |
Umar S, Sarkar S, Singh P. S1647 NF-κB Mediates Anti-Apoptotic Effect of Progastrin (PG) On Proximal (P) Colonic Crypts of Mice: Intracellular Co-Localization of PG with PG/Gastrin Receptor, Annexin-II (Anx-II), in P Colonic Crypts Gastroenterology. 134: A-241. DOI: 10.1016/S0016-5085(08)61118-X |
0.31 |
|
| 2007 |
Pannequin J, Delaunay N, Buchert M, Surrel F, Bourgaux JF, Ryan J, Boireau S, Coelho J, Pélegrin A, Singh P, Shulkes A, Yim M, Baldwin GS, Pignodel C, Lambeau G, et al. Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors. Gastroenterology. 133: 1554-68. PMID 17920061 DOI: 10.1053/J.Gastro.2007.08.023 |
0.46 |
|
| 2007 |
Rengifo-Cam W, Umar S, Sarkar S, Singh P. Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B. Cancer Research. 67: 7266-74. PMID 17671195 DOI: 10.1158/0008-5472.Can-07-1206 |
0.311 |
|
| 2007 |
Singh P. Role of Annexin-II in GI cancers: interaction with gastrins/progastrins. Cancer Letters. 252: 19-35. PMID 17188424 DOI: 10.1016/J.Canlet.2006.11.012 |
0.394 |
|
| 2007 |
Singh P, Dai B, Wu H, Owlia A. Role of autocrine and endocrine gastrin-like peptides in colonic carcinogenesis. Current Opinion in Gastroenterology. 16: 68-77. PMID 17024020 DOI: 10.1097/00001574-200001000-00013 |
0.384 |
|
| 2007 |
Singh P, Wu H, Clark C, Owlia A. Annexin II binds progastrin and gastrin-like peptides, and mediates growth factor effects of autocrine and exogenous gastrins on colon cancer and intestinal epithelial cells Oncogene. 26: 425-440. PMID 16832341 DOI: 10.1038/Sj.Onc.1209798 |
0.394 |
|
| 2005 |
Cowey SL, Quast M, Belalcazar LM, Wei J, Deng X, Given R, Singh P. Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression. Cancer. 103: 2643-53. PMID 15864814 DOI: 10.1002/Cncr.21094 |
0.331 |
|
| 2004 |
Rengifo-Cam W, Singh P. Role of progastrins and gastrins and their receptors in GI and pancreatic cancers: targets for treatment. Current Pharmaceutical Design. 10: 2345-58. PMID 15279613 DOI: 10.2174/1381612043383999 |
0.396 |
|
| 2004 |
Cobb S, Wood T, Ceci J, Varro A, Velasco M, Singh P. Intestinal expression of mutant and wild-type progastrin significantly increases colon carcinogenesis in response to azoxymethane in transgenic mice. Cancer. 100: 1311-23. PMID 15022301 DOI: 10.1002/Cncr.20094 |
0.788 |
|
| 2003 |
Wu H, Owlia A, Singh P. Precursor peptide progastrin(1-80) reduces apoptosis of intestinal epithelial cells and upregulates cytochrome c oxidase Vb levels and synthesis of ATP. American Journal of Physiology. Gastrointestinal and Liver Physiology. 285: G1097-110. PMID 12881229 DOI: 10.1152/Ajpgi.00216.2003 |
0.449 |
|
| 2003 |
Brown D, Yallampalli U, Owlia A, Singh P. pp60c-Src Kinase mediates growth effects of the full-length precursor progastrin1-80 peptide on rat intestinal epithelial cells, in vitro. Endocrinology. 144: 201-211. PMID 12488346 DOI: 10.1210/En.2002-220501 |
0.335 |
|
| 2003 |
Singh P, Lu X, Cobb S, Miller BT, Tarasova N, Varro A, Owlia A. Progastrin1-80 stimulates growth of intestinal epithelial cells in vitro via high-affinity binding sites. American Journal of Physiology. Gastrointestinal and Liver Physiology. 284: G328-39. PMID 12388191 DOI: 10.1152/Ajpgi.00351.2002 |
0.804 |
|
| 2003 |
Cobb S, Velasco M, Singh P. ProgastrinI-80 is a potent anti-apoptotic factor for clonic epithelial cells in vivo Gastroenterology. 124: A461-A462. DOI: 10.1016/S0016-5085(03)82333-8 |
0.779 |
|
| 2003 |
Cobb S, Ceci J, Wood T, Deng X, Owlia A, Varro A, Singh P. Progastrin expression in the colon promotes colonic tumor development in transgenic mice Gastroenterology. 124: A304. DOI: 10.1016/S0016-5085(03)81533-0 |
0.782 |
|
| 2002 |
Cobb S, Wood T, Tessarollo L, Velasco M, Given R, Varro A, Tarasova N, Singh P. Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice. Gastroenterology. 123: 516-30. PMID 12145805 DOI: 10.1053/Gast.2002.34754 |
0.776 |
|
| 2001 |
Singh P, Miller B, Owlia A. The growth promoting effects of amidated gastrins (G-17) on normal and cancerous cells is dictated by the ratio of gastrin preferring receptors (GP-R) and CCKB-R expressed by the target cells Gastroenterology. 120: A507-A508. DOI: 10.1016/S0016-5085(08)82519-X |
0.351 |
|
| 2001 |
Cobb S, Given R, Velasco M, Wood T, Tessarollo L, Varro A, Singh P. Loss of functional gastrin gene results in significantly increasing the incidence of pre-neoplastic and neoplastic changes in the colonic mucosa of mice in response to azoxymethane (AOM) Gastroenterology. 120: A164. DOI: 10.1016/S0016-5085(08)80809-8 |
0.772 |
|
| 2001 |
Cobb S, Owlia A, Lu XB, Given R, Velasco M, Miller B, Varro A, Singh P. Full-length, unprocessed, progastrin peptide (PG) exerts proliferative effects on colonic mucosa of mice via high affinity binding sites, that are specific for gastrin-like peptides with negligible affinity for cholecystokinin Gastroenterology. 120: A39. DOI: 10.1016/S0016-5085(08)80189-8 |
0.758 |
|
| 2000 |
Dai B, Wu H, Holthuizen E, Singh P. Identification of a novel cis element required for cell density-dependent down-regulation of insulin-like growth factor-2 P3 promoter activity in Caco2 cells. The Journal of Biological Chemistry. 276: 6937-44. PMID 11112775 DOI: 10.1074/Jbc.M007789200 |
0.314 |
|
| 2000 |
Wu H, Rao GN, Dai B, Singh P. Autocrine gastrins in colon cancer cells Up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3. The Journal of Biological Chemistry. 275: 32491-8. PMID 10915781 DOI: 10.1074/Jbc.M002458200 |
0.394 |
|
| 2000 |
Singh P, Velasco M, Given R, Varro A, Wang TC. Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. Gastroenterology. 119: 162-71. PMID 10889165 DOI: 10.1053/Gast.2000.8527 |
0.448 |
|
| 2000 |
Singh P, Velasco M, Given R, Wargovich M, Varro A, Wang TC. Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM. American Journal of Physiology. Gastrointestinal and Liver Physiology. 278: G390-9. PMID 10712258 DOI: 10.1152/Ajpgi.2000.278.3.G390 |
0.397 |
|
| 2000 |
Singh P, Cobb S, Velasco M, Wood T, Tessarollo L, Given R, Varro A. Mice targeted for gastrin gene disruption are more susceptible to colon carcinogenesis in response to the chemical carcinogin, azoxymethane (AOM) Regulatory Peptides. 94: 44. DOI: 10.1016/S0167-0115(00)80089-0 |
0.771 |
|
| 2000 |
Singh P, Lu XB, Varro A, Owlia A. Expression of unprocessed, full-length progastrin, and its biological efficacy on normal and cancerous intestinal cells Regulatory Peptides. 94: 22. DOI: 10.1016/S0167-0115(00)80044-0 |
0.424 |
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| 2000 |
Singh P, Wu H, Rao GN, Dai B. Autocrine gastrins in colon cancer cells up-regulate cytochrome C oxidase VB (COX VB) and down-regulate efflux of cytochrome C in activation of caspase 3 Regulatory Peptides. 94: 6. DOI: 10.1016/S0167-0115(00)80012-9 |
0.34 |
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| 2000 |
Singh P, Lu XB, Varro A, Owlia A. Progastrin (PG) is equally effective as amidated gastrin-17 (G-17) as a growth factor for intestinal epithelial cells (IEC6) and pancreatic cancer cells (AR42J) Gastroenterology. 118: A562. DOI: 10.1016/S0016-5085(00)84383-8 |
0.438 |
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| 2000 |
Wu H, Rao GN, Singh P. Mitochondrial (MT) cytochrome C oxidase (COX) in human colon cancer cells may mediate survival effects of autocrine gastrins in human colon cancer cells Gastroenterology. 118: A444. DOI: 10.1016/S0016-5085(00)83887-1 |
0.384 |
|
| 1999 |
Qin C, Singh P, Safe S. Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes. Endocrinology. 140: 2501-8. PMID 10342835 DOI: 10.1210/Endo.140.6.6751 |
0.342 |
|
| 1998 |
Singh P, Dai B, Given RL, Lu X, Holthuizen PE. Differential activation of IGF-II promoters P3 and P4 in Caco-2 cells during growth and differentiation. Gastroenterology. 114: 1221-9. PMID 9609759 DOI: 10.1016/S0016-5085(98)70428-7 |
0.347 |
|
| 1998 |
Singh P, Owlia A. Tumorigenicity of a human colon cancer cell line is significantly reduced, in vivo, in the presence of colon cancer cells overexpressing antisense gastrin mRNA: Role of inhibitory (endocrine) factors in the observed bystander effects Gastroenterology. 114: A680-A681. DOI: 10.1016/S0016-5085(98)82791-1 |
0.343 |
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| 1998 |
Singh P, Velasco M, Given R, Owlia A, Wargovich M, Wang T. High levels of progastrin significantly increase premalignant changes in colonic mucosa of mice in response to the chemical carcinogen, AOM Gastroenterology. 114: A680. DOI: 10.1016/S0016-5085(98)82790-X |
0.357 |
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| 1997 |
Dai B, Widen SG, Mifflin R, Singh P. Cloning of the functional promoter for human insulin-like growth factor binding protein-4 gene: endogenous regulation. Endocrinology. 138: 332-43. PMID 8977421 DOI: 10.1210/Endo.138.1.4901 |
0.393 |
|
| 1996 |
Singh P. Gastrin gene products and gastrin receptors in colon cancer. Gastroenterology. 111: 268-9. PMID 8698216 DOI: 10.1053/Gast.1996.V111.Agast961110268 |
0.319 |
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| 1996 |
Singh P, Dai B, Yallampalli U, Lu X, Schroy PC. Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II. Endocrinology. 137: 1764-74. PMID 8612513 DOI: 10.1210/Endo.137.5.8612513 |
0.356 |
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| 1995 |
Singh P, Owlia A, Espeijo R, Dai B. Novel gastrin receptors mediate mitogenic effects of gastrin and processing intermediates of gastrin on Swiss 3T3 fibroblasts. Absence of detectable cholecystokinin (CCK)-A and CCK-B receptors. The Journal of Biological Chemistry. 270: 8429-38. PMID 7721737 DOI: 10.1074/Jbc.270.15.8429 |
0.33 |
|
| 1994 |
Singh P, Xu Z, Dai B, Rajaraman S, Rubin N, Dhruva B. Incomplete processing of progastrin expressed by human colon cancer cells: role of noncarboxyamidated gastrins. The American Journal of Physiology. 266: G459-68. PMID 8166285 DOI: 10.1152/Ajpgi.1994.266.3.G459 |
0.415 |
|
| 1994 |
Singh P, Narayan S, Adiga RB. Phosphorylation of pp62 and pp54 src-like proteins in a rat intestinal cell line in response to gastrin. The American Journal of Physiology. 267: G235-44. PMID 8074224 DOI: 10.1152/Ajpgi.1994.267.2.G235 |
0.349 |
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| 1994 |
Singh P, Dai B, Yallampalli C, Xu Z. Expression of IGF-II and IGF-binding proteins by colon cancer cells in relation to growth response to IGFs American Journal of Physiology - Gastrointestinal and Liver Physiology. 267: G608-G617. PMID 7524348 DOI: 10.1152/Ajpgi.1994.267.4.G608 |
0.367 |
|
| 1994 |
Xu Z, Dai B, Dhruva B, Singh P. Gastrin gene expression in human colon cancer cells measured by a simple competitive PCR method. Life Sciences. 54: 671-8. PMID 7509020 DOI: 10.1016/0024-3205(94)00550-8 |
0.405 |
|
| 1993 |
Singh P, Reubi JC, Rajakumar G, Guo YS, Prioux H, Chicone L. In vivo mitogenic effects of estradiol on colon cancers: role of gastrin and gastrin receptors. The Journal of Steroid Biochemistry and Molecular Biology. 46: 49-60. PMID 8338790 DOI: 10.1016/0960-0760(93)90208-E |
0.391 |
|
| 1993 |
Singh P, Rubin N. Insulinlike growth factors and binding proteins in colon cancer. Gastroenterology. 105: 1218-37. PMID 7691674 DOI: 10.1016/0016-5085(93)90971-E |
0.349 |
|
| 1993 |
Narayan S, Rajakumar G, Prouix H, Singh P. Estradiol is trophic for colon cancer in mice: effect on ornithine decarboxylase and c-myc messenger RNA. Gastroenterology. 103: 1823-32. PMID 1451976 DOI: 10.1016/0016-5085(92)91441-6 |
0.384 |
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| 1992 |
Singh P, Townsend CM, Poston GJ, Reubi JC. Specific binding of cholecystokinin, estradiol and somatostatin to human pancreatic cancer xenografts. The Journal of Steroid Biochemistry and Molecular Biology. 39: 759-67. PMID 1683561 DOI: 10.1016/0960-0760(91)90377-H |
0.325 |
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| 1992 |
Guo YS, Narayan S, Yallampalli C, Singh P. Characterization of insulinlike growth factor I receptors in human colon cancer Gastroenterology. 102: 1101-1108. PMID 1312970 DOI: 10.1016/0016-5085(92)90744-J |
0.41 |
|
| 1991 |
Evers BM, Townsend CM, Upp JR, Allen E, Hurlbut SC, Kim SW, Rajaraman S, Singh P, Reubi JC, Thompson JC. Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth. Gastroenterology. 101: 303-11. PMID 1712329 DOI: 10.1016/0016-5085(91)90004-5 |
0.368 |
|
| 1991 |
Singh P, Narayan S, Guo YS, Chandrasekhar Y. IGF-I and IGF-I receptor in mouse colon cancer cells In Vitro Cellular &Amp; Developmental Biology - Animal. 27: 755-758. PMID 1660048 DOI: 10.1007/Bf02631237 |
0.399 |
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| 1990 |
Guo YS, Baijal M, Jin GF, Thompson JC, Townsend CM, Singh P. Growth-promoting effects of gastrin on mouse colon cancer cells in vitro: absence of autocrine effects. In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association. 26: 871-7. PMID 2228904 DOI: 10.1007/Bf02624612 |
0.429 |
|
| 1990 |
Guo YS, Draviam E, Townsend CM, Singh P. Differential effects of Ca2+ on proliferation of stomach, colonic, and pancreatic cancer cell lines in vitro Nutrition and Cancer. 14: 149-157. PMID 2216899 DOI: 10.1080/01635589009514089 |
0.409 |
|
| 1990 |
Singh P, Draviam E, Guo YS, Kurosky A. Molecular characterization of bombesin receptors on rat pancreatic acinar AR42J cells American Journal of Physiology - Gastrointestinal and Liver Physiology. 258. PMID 2159242 DOI: 10.1152/Ajpgi.1990.258.5.G803 |
0.321 |
|
| 1990 |
Poston GJ, Townsend CM, Rajaraman S, Thompson JC, Singh P. Effect of somatostatin and tamoxifen on the growth of human pancreatic cancers in nude mice Pancreas. 5: 151-157. PMID 2156257 DOI: 10.1097/00006676-199003000-00005 |
0.348 |
|
| 1989 |
Chicone L, Narayan S, Townsend CM, Singh P. The presence of a 33-40 KDa gastrin binding protein on human and mouse colon cancer. Biochemical and Biophysical Research Communications. 164: 512-9. PMID 2803316 DOI: 10.1016/0006-291X(89)91749-X |
0.334 |
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| 1988 |
Alexander RW, Upp JR, Poston GJ, Townsend CM, Singh P, Thompson JC. Bombesin inhibits growth of human pancreatic adenocarcinoma in nude mice. Pancreas. 3: 297-302. PMID 2838842 DOI: 10.1097/00006676-198805000-00010 |
0.365 |
|
| 1988 |
SINGH H, KUMAR A, TOWNSEND CM, SAMAD Z, SINGH P. A Synthetic Peptide, L-8-K, and Its Antibody Both Inhibit the Specific Binding of Vasoactive Intestinal Peptide to Hamster Pancreatic Cancer Cells Annals of the New York Academy of Sciences. 527: 679-681. DOI: 10.1111/J.1749-6632.1988.Tb27041.X |
0.328 |
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