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Daniel W. Nebert - Publications

Affiliations: 
University of Cincinnati, Cincinnati, OH 
Area:
Toxicology, Cell Biology, Molecular Biology
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Year Citation  Score
2020 Thompson B, Davidson EA, Liu W, Nebert DW, Bruford EA, Zhao H, Dermitzakis ET, Thompson DC, Vasiliou V. Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease. Human Genetics. PMID 32728807 DOI: 10.1007/S00439-020-02212-9  0.341
2019 Nebert DW, Liu Z. SLC39A8 gene encoding a metal ion transporter: discovery and bench to bedside. Human Genomics. 13: 51. PMID 31521203 DOI: 10.1186/S40246-019-0233-3  0.364
2019 Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC, Vasiliou V, Nebert DW. Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom". Human Genomics. 13: 11. PMID 30782214 DOI: 10.1186/S40246-019-0191-9  0.387
2018 Chen J, Gálvez-Peralta M, Zhang X, Deng J, Liu Z, Nebert DW. In utero gene expression in the Slc39a8(neo/neo) knockdown mouse. Scientific Reports. 8: 10703. PMID 30013175 DOI: 10.1038/S41598-018-29109-Y  0.397
2018 Liu L, Geng X, Cai Y, Copple BL, Yoshinaga M, Shen J, Nebert DW, Wang H, Liu Z. Hepatic ZIP8 deficiency is associated with disrupted selenium homeostasis, liver pathology and tumor formation. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 29927321 DOI: 10.1152/Ajpgi.00165.2018  0.32
2018 Uno S, Nebert DW, Makishima M. Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 29366871 DOI: 10.1016/J.Fct.2018.01.029  0.397
2017 Nebert DW. Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals. Progress in Lipid Research. PMID 28606467 DOI: 10.1016/J.Plipres.2017.06.001  0.345
2017 Schiering C, Wincent E, Metidji A, Iseppon A, Li Y, Potocnik AJ, Omenetti S, Henderson CJ, Wolf CR, Nebert DW, Stockinger B. Feedback control of AHR signalling regulates intestinal immunity. Nature. PMID 28146477 DOI: 10.1038/Nature21080  0.351
2016 Jorge-Nebert LF, Zhang G, Wilson KM, Jiang Z, Butler R, Gluckman JL, Pinney SM, Nebert DW. Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype. Human Genomics. 10: 39. PMID 27894333 DOI: 10.1186/S40246-016-0094-Y  0.315
2016 Nebert DW, Dong H, Bruford EA, Thompson DC, Joenje H, Vasiliou V. Letter to the editor for "Update of the human and mouse Fanconi anemia genes". Human Genomics. 10: 25. PMID 27377885 DOI: 10.1186/S40246-016-0081-3  0.308
2016 McDermott JR, Geng X, Jiang L, Gálvez-Peralta M, Chen F, Nebert DW, Liu Z. Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake. Oncotarget. PMID 27166256 DOI: 10.18632/Oncotarget.9205  0.324
2015 Boycott KM, Beaulieu CL, Kernohan KD, Gebril OH, Mhanni A, Chudley AE, Redl D, Qin W, Hampson S, Küry S, Tetreault M, Puffenberger EG, Scott JN, Bezieau S, Reis A, ... ... Nebert DW, et al. Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8. American Journal of Human Genetics. 97: 886-93. PMID 26637978 DOI: 10.1016/J.Ajhg.2015.11.002  0.307
2015 Dong H, Nebert DW, Bruford EA, Thompson DC, Joenje H, Vasiliou V. Update of the human and mouse Fanconi anemia genes. Human Genomics. 9: 32. PMID 26596371 DOI: 10.1186/S40246-015-0054-Y  0.371
2015 Jorge-Nebert LF, Gálvez-Peralta M, Landero Figueroa J, Somarathna M, Hojyo S, Fukada T, Nebert DW. Comparing gene expression during cadmium uptake and distribution: untreated versus oral Cd-treated wild-type and ZIP14 knockout mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 143: 26-35. PMID 25294218 DOI: 10.1093/Toxsci/Kfu204  0.325
2014 Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B. Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 68-77. PMID 24893714 DOI: 10.1093/Toxsci/Kfu106  0.335
2014 Gálvez-Peralta M, Wang Z, Bao S, Knoell DL, Nebert DW. Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals. International Journal of Toxicology. 33: 246-258. PMID 24728862 DOI: 10.1177/1091581814529310  0.317
2014 Uno S, Sakurai K, Nebert DW, Makishima M. Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta. Toxicology. 316: 34-42. PMID 24394547 DOI: 10.1016/J.Tox.2013.12.005  0.387
2014 Schneider SN, Liu Z, Wang B, Miller ML, Afton SE, Soleimani M, Nebert DW. Oral cadmium in mice carrying 5 versus 2 copies of the Slc39a8 gene: comparison of uptake, distribution, metal content, and toxicity. International Journal of Toxicology. 33: 14-20. PMID 24345748 DOI: 10.1177/1091581813513530  0.355
2013 Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V. Update of the human and mouse SERPIN gene superfamily. Human Genomics. 7: 22. PMID 24172014 DOI: 10.1186/1479-7364-7-22  0.353
2013 Divanovic S, Dalli J, Jorge-Nebert LF, Flick LM, Gálvez-Peralta M, Boespflug ND, Stankiewicz TE, Fitzgerald JM, Somarathna M, Karp CL, Serhan CN, Nebert DW. Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways. Journal of Immunology (Baltimore, Md. : 1950). 191: 3347-57. PMID 23956430 DOI: 10.4049/Jimmunol.1300699  0.352
2013 Chen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V. Glutathione defense mechanism in liver injury: Insights from animal models Food and Chemical Toxicology. 60: 38-44. PMID 23856494 DOI: 10.1016/J.Fct.2013.07.008  0.358
2013 Iqbal J, Sun L, Cao J, Yuen T, Lu P, Bab I, Leu NA, Srinivasan S, Wagage S, Hunter CA, Nebert DW, Zaidi M, Avadhani NG. Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes. Proceedings of the National Academy of Sciences of the United States of America. 110: 11115-20. PMID 23776235 DOI: 10.1073/Pnas.1220919110  0.316
2013 Nebert DW, Shi Z, Gálvez-Peralta M, Uno S, Dragin N. Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm. Molecular Pharmacology. 84: 304-13. PMID 23761301 DOI: 10.1124/Mol.113.086637  0.344
2013 Dong H, Shertzer HG, Genter MB, Gonzalez FJ, Vasiliou V, Jefcoate C, Nebert DW. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochemical and Biophysical Research Communications. 435: 727-32. PMID 23692925 DOI: 10.1016/J.Bbrc.2013.05.051  0.337
2013 Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL. ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. Cell Reports. 3: 386-400. PMID 23403290 DOI: 10.1016/J.Celrep.2013.01.009  0.312
2013 Nebert DW, Wikvall K, Miller WL. Human cytochromes P450 in health and disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20120431. PMID 23297354 DOI: 10.1098/Rstb.2012.0431  0.375
2013 Gálvez-Peralta M, Shi Z, Chen J, Miller ML, Nebert DW. Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct. International Journal of Cancer. Journal International Du Cancer. 132: 2065-75. PMID 23047765 DOI: 10.1002/Ijc.27897  0.442
2013 Brocker C, Vasiliou M, Carpenter S, Carpenter C, Zhang Y, Wang X, Kotchoni SO, Wood AJ, Kirch HH, Kope?ný D, Nebert DW, Vasiliou V. Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics. Planta. 237: 189-210. PMID 23007552 DOI: 10.1007/S00425-012-1749-0  0.349
2012 Nebert DW, Gálvez-Peralta M, Hay EB, Li H, Johansson E, Yin C, Wang B, He L, Soleimani M. ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition. Metallomics : Integrated Biometal Science. 4: 1218-25. PMID 23090441 DOI: 10.1039/C2Mt20177A  0.321
2012 Levova K, Moserova M, Nebert DW, Phillips DH, Frei E, Schmeiser HH, Arlt VM, Stiborova M. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. Toxicology and Applied Pharmacology. 265: 360-7. PMID 22982977 DOI: 10.1016/J.Taap.2012.09.004  0.426
2012 Chen Y, Curran CP, Nebert DW, Patel KV, Williams MT, Vorhees CV. Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice. Neurotoxicology and Teratology. 34: 450-7. PMID 22580179 DOI: 10.1016/J.Ntt.2012.04.009  0.729
2012 Gálvez-Peralta M, He L, Jorge-Nebert LF, Wang B, Miller ML, Eppert BL, Afton S, Nebert DW. ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero. Plos One. 7: e36055. PMID 22563477 DOI: 10.1371/Journal.Pone.0036055  0.342
2012 Chen Y, Curran CP, Nebert DW, Patel KV, Williams MT, Vorhees CV. Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice. Genes, Brain, and Behavior. 11: 269-77. PMID 22296218 DOI: 10.1111/J.1601-183X.2011.00762.X  0.718
2012 Stiborová M, Levová K, Bárta F, Shi Z, Frei E, Schmeiser HH, Nebert DW, Phillips DH, Arlt VM. Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. Toxicological Sciences : An Official Journal of the Society of Toxicology. 125: 345-58. PMID 22086975 DOI: 10.1093/Toxsci/Kfr306  0.383
2012 Chen Y, Krishan M, Nebert DW, Shertzer HG. Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis. Chemical Research in Toxicology. 25: 94-100. PMID 22082335 DOI: 10.1021/Tx200242A  0.402
2012 Curran C, Chen Y, Nebert D, Patel K, Williams M, Vorhees C. Behavioral phenotyping of two mouse lines with reduced antioxidant capacity Neurotoxicology and Teratology. 34: 378. DOI: 10.1016/J.Ntt.2012.05.032  0.679
2011 Jackson BC, Thompson DC, Wright MW, McAndrews M, Bernard A, Nebert DW, Vasiliou V. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. Human Genomics. 5: 691-702. PMID 22155607 DOI: 10.1186/1479-7364-5-6-691  0.385
2011 Kendig EL, Chen Y, Krishan M, Johansson E, Schneider SN, Genter MB, Nebert DW, Shertzer HG. Lipid metabolism and body composition in Gclm(-/-) mice. Toxicology and Applied Pharmacology. 257: 338-48. PMID 21967773 DOI: 10.1016/J.Taap.2011.09.017  0.369
2011 Arlt VM, Levová K, Bárta F, Shi Z, Evans JD, Frei E, Schmeiser HH, Nebert DW, Phillips DH, Stiborová M. Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice. Chemical Research in Toxicology. 24: 1710-9. PMID 21932800 DOI: 10.1021/Tx200259Y  0.328
2011 Jackson B, Brocker C, Thompson DC, Black W, Vasiliou K, Nebert DW, Vasiliou V. Update on the aldehyde dehydrogenase gene (ALDH) superfamily. Human Genomics. 5: 283-303. PMID 21712190 DOI: 10.1186/1479-7364-5-4-283  0.4
2011 Wang B, He L, Dong H, Dalton TP, Nebert DW. Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression. Biochemical and Biophysical Research Communications. 410: 289-94. PMID 21658371 DOI: 10.1016/J.Bbrc.2011.05.134  0.342
2011 Waits ER, Nebert DW. Genetic architecture of susceptibility to PCB126-induced developmental cardiotoxicity in zebrafish. Toxicological Sciences : An Official Journal of the Society of Toxicology. 122: 466-75. PMID 21613231 DOI: 10.1093/Toxsci/Kfr136  0.791
2011 Curran CP, Nebert DW, Genter MB, Patel KV, Schaefer TL, Skelton MR, Williams MT, Vorhees CV. In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. Environmental Health Perspectives. 119: 1286-93. PMID 21571617 DOI: 10.1289/Ehp.1002965  0.728
2011 Ozeki J, Uno S, Ogura M, Choi M, Maeda T, Sakurai K, Matsuo S, Amano S, Nebert DW, Makishima M. Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice. Toxicology. 280: 10-7. PMID 21095216 DOI: 10.1016/J.Tox.2010.11.003  0.4
2011 Curran CP, Vorhees CV, Williams MT, Genter MB, Miller ML, Nebert DW. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 119: 189-208. PMID 20961953 DOI: 10.1093/Toxsci/Kfq314  0.725
2010 Brocker C, Carpenter C, Nebert DW, Vasiliou V. Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family. Human Genomics. 4: 411-20. PMID 20846931 DOI: 10.1186/1479-7364-4-6-411  0.343
2010 Chen Y, Johansson E, Yang Y, Miller ML, Shen D, Orlicky DJ, Shertzer HG, Vasiliou V, Nebert DW, Dalton TP. Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis. Journal of Hepatology. 53: 1085-94. PMID 20810184 DOI: 10.1016/J.Jhep.2010.05.028  0.338
2010 Nebert DW, Gálvez-Peralta M, Shi Z, Dragin N. Inbreeding and epigenetics: beneficial as well as deleterious effects. Nature Reviews. Genetics. 11: 662. PMID 20661256 DOI: 10.1038/Nrg2664-C2  0.347
2010 Jackson BC, Carpenter C, Nebert DW, Vasiliou V. Update of human and mouse forkhead box (FOX) gene families. Human Genomics. 4: 345-52. PMID 20650821 DOI: 10.1186/1479-7364-4-5-345  0.383
2010 Shi Z, Dragin N, Gálvez-Peralta M, Jorge-Nebert LF, Miller ML, Wang B, Nebert DW. Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene. Molecular Pharmacology. 78: 46-57. PMID 20371670 DOI: 10.1124/Mol.110.063438  0.384
2010 Shi Z, Dragin N, Miller ML, Stringer KF, Johansson E, Chen J, Uno S, Gonzalez FJ, Rubio CA, Nebert DW. Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype. International Journal of Cancer. Journal International Du Cancer. 127: 2334-50. PMID 20127859 DOI: 10.1002/Ijc.25222  0.451
2010 Fan Y, Boivin GP, Knudsen ES, Nebert DW, Xia Y, Puga A. The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer Research. 70: 212-20. PMID 19996281 DOI: 10.1158/0008-5472.Can-09-3090  0.395
2010 Jorge-Nebert LF, Jiang Z, Chakraborty R, Watson J, Jin L, McGarvey ST, Deka R, Nebert DW. Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations. Human Mutation. 31: 27-40. PMID 19802894 DOI: 10.1002/Humu.21132  0.381
2009 Brocker CN, Vasiliou V, Nebert DW. Evolutionary divergence and functions of the ADAM and ADAMTS gene families. Human Genomics. 4: 43-55. PMID 19951893 DOI: 10.1186/1479-7364-4-1-43  0.33
2009 Black WJ, Stagos D, Marchitti SA, Nebert DW, Tipton KF, Bairoch A, Vasiliou V. Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature. Pharmacogenetics and Genomics. 19: 893-902. PMID 19823103 DOI: 10.1097/Fpc.0B013E3283329023  0.403
2009 Nebert DW. Given the complexity of the human genome, can 'personalised medicine' or 'individualised drug therapy' ever be achieved? Human Genomics. 3: 299-300. PMID 19706359 DOI: 10.1186/1479-7364-3-4-299  0.351
2009 Sim SC, Miller WL, Zhong XB, Arlt W, Ogata T, Ding X, Wolf CR, Flück CE, Pandey AV, Henderson CJ, Porter TD, Daly AK, Nebert DW, Ingelman-Sundberg M. Nomenclature for alleles of the cytochrome P450 oxidoreductase gene. Pharmacogenetics and Genomics. 19: 565-6. PMID 19535965 DOI: 10.1097/Fpc.0B013E32832Af5B7  0.363
2009 Chen Y, Johansson E, Fan Y, Shertzer HG, Vasiliou V, Nebert DW, Dalton TP. Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit. Free Radical Biology & Medicine. 47: 410-8. PMID 19427898 DOI: 10.1016/J.Freeradbiomed.2009.05.003  0.345
2009 Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW. CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines. Toxicology and Applied Pharmacology. 237: 119-26. PMID 19285097 DOI: 10.1016/J.Taap.2009.03.001  0.42
2009 He L, Wang B, Hay EB, Nebert DW. Discovery of ZIP transporters that participate in cadmium damage to testis and kidney. Toxicology and Applied Pharmacology. 238: 250-7. PMID 19265717 DOI: 10.1016/J.Taap.2009.02.017  0.304
2009 He L, Vasiliou K, Nebert DW. Analysis and update of the human solute carrier (SLC) gene superfamily. Human Genomics. 3: 195-206. PMID 19164095 DOI: 10.1186/1479-7364-3-2-195  0.332
2009 Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW. Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle. Molecular Pharmacology. 75: 555-67. PMID 19047483 DOI: 10.1124/Mol.108.051888  0.356
2009 Curran C, Patel K, Willilams M, Vorhees C, Nebert D. Differential neurobehavioral responses in PCB-treated mice having different Ahr and Cyp1a2 alleles Neurotoxicology and Teratology. 31: 240-241. DOI: 10.1016/J.Ntt.2009.04.020  0.72
2008 Olender T, Lancet D, Nebert DW. Update on the olfactory receptor (OR) gene superfamily. Human Genomics. 3: 87-97. PMID 19129093 DOI: 10.1186/1479-7364-3-1-87  0.367
2008 Shi Z, Chen Y, Dong H, Amos-Kroohs RM, Nebert DW. Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor. Biochemical and Biophysical Research Communications. 376: 775-80. PMID 18814841 DOI: 10.1016/J.Bbrc.2008.09.068  0.354
2008 Nebert DW, Karp CL. Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology. The Journal of Biological Chemistry. 283: 36061-5. PMID 18713746 DOI: 10.1074/Jbc.R800053200  0.436
2008 Dragin N, Shi Z, Madan R, Karp CL, Sartor MA, Chen C, Gonzalez FJ, Nebert DW. Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse. Molecular Pharmacology. 73: 1844-56. PMID 18372398 DOI: 10.1124/Mol.108.045658  0.439
2008 Girijashanker K, He L, Soleimani M, Reed JM, Li H, Liu Z, Wang B, Dalton TP, Nebert DW. Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter. Molecular Pharmacology. 73: 1413-23. PMID 18270315 DOI: 10.1124/Mol.107.043588  0.344
2008 Cotton RG, Auerbach AD, Beckmann JS, Blumenfeld OO, Brookes AJ, Brown AF, Carrera P, Cox DW, Gottlieb B, Greenblatt MS, Hilbert P, Lehvaslaiho H, Liang P, Marsh S, Nebert DW, et al. Recommendations for locus-specific databases and their curation. Human Mutation. 29: 2-5. PMID 18157828 DOI: 10.1002/Humu.20650  0.307
2008 Uno S, Dragin N, Miller ML, Dalton TP, Gonzalez FJ, Nebert DW. Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. Free Radical Biology & Medicine. 44: 570-83. PMID 17997381 DOI: 10.1016/J.Freeradbiomed.2007.10.044  0.394
2007 Dragin N, Uno S, Wang B, Dalton TP, Nebert DW. Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line. Biochemical and Biophysical Research Communications. 359: 635-42. PMID 17560947 DOI: 10.1016/J.Bbrc.2007.05.202  0.41
2007 Yang Y, Chen Y, Johansson E, Schneider SN, Shertzer HG, Nebert DW, Dalton TP. Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase. Biochemical Pharmacology. 74: 372-81. PMID 17517378 DOI: 10.1016/J.Bcp.2007.02.003  0.315
2007 Chen Y, Yang Y, Miller ML, Shen D, Shertzer HG, Stringer KF, Wang B, Schneider SN, Nebert DW, Dalton TP. Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology (Baltimore, Md.). 45: 1118-28. PMID 17464988 DOI: 10.1002/Hep.21635  0.345
2007 Shertzer HG, Genter MB, Talaska G, Curran CP, Nebert DW, Dalton TP. 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis. 28: 1371-8. PMID 17166882 DOI: 10.1093/Carcin/Bgl244  0.747
2007 Wang B, Schneider SN, Dragin N, Girijashanker K, Dalton TP, He L, Miller ML, Stringer KF, Soleimani M, Richardson DD, Nebert DW. Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line. American Journal of Physiology. Cell Physiology. 292: C1523-35. PMID 17108009 DOI: 10.1152/Ajpcell.00409.2006  0.371
2007 Ma X, Idle JR, Malfatti MA, Krausz KW, Nebert DW, Chen CS, Felton JS, Waxman DJ, Gonzalez FJ. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 28: 732-7. PMID 17052995 DOI: 10.1093/Carcin/Bgl184  0.37
2006 Nebert DW, Dalton TP. The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nature Reviews. Cancer. 6: 947-60. PMID 17128211 DOI: 10.1038/Nrc2015  0.4
2006 Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ. The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Developmental Biology. 300: 366-84. PMID 17097629 DOI: 10.1016/J.Ydbio.2006.08.066  0.389
2006 Genter MB, Marlowe J, Kevin Kerzee J, Dragin N, Puga A, Dalton TP, Nebert DW. Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. Biochemical and Biophysical Research Communications. 348: 120-3. PMID 16876762 DOI: 10.1016/J.Bbrc.2006.07.025  0.325
2006 He L, Girijashanker K, Dalton TP, Reed J, Li H, Soleimani M, Nebert DW. ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties. Molecular Pharmacology. 70: 171-80. PMID 16638970 DOI: 10.1124/Mol.106.024521  0.302
2006 Dragin N, Dalton TP, Miller ML, Shertzer HG, Nebert DW. For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. The Journal of Biological Chemistry. 281: 18591-600. PMID 16636061 DOI: 10.1074/Jbc.M601159200  0.453
2006 Jiang Z, Dragin N, Jorge-Nebert LF, Martin MV, Guengerich FP, Aklillu E, Ingelman-Sundberg M, Hammons GJ, Lyn-Cook BD, Kadlubar FF, Saldana SN, Sorter M, Vinks AA, Nassr N, von Richter O, ... ... Nebert DW, et al. Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. Pharmacogenetics and Genomics. 16: 359-67. PMID 16609368 DOI: 10.1097/01.Fpc.0000204994.99429.46  0.36
2006 Vasiliou V, Ross D, Nebert DW. Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. Human Genomics. 2: 329-35. PMID 16595077 DOI: 10.1186/1479-7364-2-5-329  0.399
2006 Genter MB, Clay CD, Dalton TP, Dong H, Nebert DW, Shertzer HG. Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment. Biochemical and Biophysical Research Communications. 342: 1375-81. PMID 16516144 DOI: 10.1016/J.Bbrc.2006.02.121  0.39
2006 Li Y, Zhang D, Jin W, Shao C, Yan P, Xu C, Sheng H, Liu Y, Yu J, Xie Y, Zhao Y, Lu D, Nebert DW, Harrison DC, Huang W, et al. Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. The Journal of Clinical Investigation. 116: 506-11. PMID 16440063 DOI: 10.1172/Jci26564  0.324
2006 Uno S, Dalton TP, Dragin N, Curran CP, Derkenne S, Miller ML, Shertzer HG, Gonzalez FJ, Nebert DW. Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Molecular Pharmacology. 69: 1103-14. PMID 16377763 DOI: 10.1124/Mol.105.021501  0.743
2006 Nebert DW. Comparison of gene expression in cell culture to that in the intact animal: relevance to drugs and environmental toxicants. Focus on "development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes". American Journal of Physiology. Cell Physiology. 290: C37-41. PMID 16338979 DOI: 10.1152/Ajpcell.00444.2005  0.349
2006 Curran CP, Miller KA, Dalton TP, Vorhees CV, Miller ML, Shertzer HG, Nebert DW. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicological Sciences : An Official Journal of the Society of Toxicology. 89: 454-64. PMID 16291824 DOI: 10.1093/Toxsci/Kfj048  0.717
2005 Cheung C, Ma X, Krausz KW, Kimura S, Feigenbaum L, Dalton TP, Nebert DW, Idle JR, Gonzalez FJ. Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2. Chemical Research in Toxicology. 18: 1471-8. PMID 16167840 DOI: 10.1021/Tx050136G  0.403
2005 Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenetics and Genomics. 15: 677-85. PMID 16141793 DOI: 10.1097/01.Fpc.0000173483.13689.56  0.393
2005 Chen Y, Shertzer HG, Schneider SN, Nebert DW, Dalton TP. Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels. The Journal of Biological Chemistry. 280: 33766-74. PMID 16081425 DOI: 10.1074/Jbc.M504604200  0.318
2005 Vasiliou V, Nebert DW. Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. Human Genomics. 2: 138-43. PMID 16004729 DOI: 10.1186/1479-7364-2-2-138  0.414
2005 Derkenne S, Curran CP, Shertzer HG, Dalton TP, Dragin N, Nebert DW. Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice. Pharmacogenetics and Genomics. 15: 503-11. PMID 15970798 DOI: 10.1097/01.Fpc.0000167326.00411.50  0.746
2005 Shen D, Dalton TP, Nebert DW, Shertzer HG. Glutathione redox state regulates mitochondrial reactive oxygen production. The Journal of Biological Chemistry. 280: 25305-12. PMID 15883162 DOI: 10.1074/Jbc.M500095200  0.308
2005 Liu H, Zhang S, Lin J, Li H, Huang A, Xiao C, Li X, Su Z, Wang C, Nebert DW, Zhou B, Zheng K, Shi J, Li G, Huang D. Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese. Metabolism: Clinical and Experimental. 54: 568-72. PMID 15877284 DOI: 10.1016/J.Metabol.2004.11.009  0.308
2005 Greaves P, Clothier B, Davies R, Higginson FM, Edwards RE, Dalton TP, Nebert DW, Smith AG. Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse. Biochemical and Biophysical Research Communications. 331: 147-52. PMID 15845371 DOI: 10.1016/J.Bbrc.2005.03.136  0.358
2005 Dalton TP, He L, Wang B, Miller ML, Jin L, Stringer KF, Chang X, Baxter CS, Nebert DW. Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. Proceedings of the National Academy of Sciences of the United States of America. 102: 3401-6. PMID 15722412 DOI: 10.1073/Pnas.0406085102  0.331
2005 Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW. Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. Human Mutation. 25: 196-206. PMID 15643613 DOI: 10.1002/Humu.20134  0.413
2005 Nebert DW, Wain HM. Update on human genome completion and annotations: gene nomenclature. Human Genomics. 1: 66-71. PMID 15601535 DOI: 10.1186/1479-7364-1-1-66  0.351
2005 NEGISHI M, JENSEN NM, GARCIA GS, NEBERT DW. Structural Gene Products of the Murine Ah Complex European Journal of Biochemistry. 115: 585-594. DOI: 10.1111/J.1432-1033.1981.Tb06243.X  0.353
2004 Nebert DW, Vasiliou V. Analysis of the glutathione S-transferase (GST) gene family. Human Genomics. 1: 460-4. PMID 15607001 DOI: 10.1186/1479-7364-1-6-460  0.387
2004 Kleiner HE, Vulimiri SV, Hatten WB, Reed MJ, Nebert DW, Jefcoate CR, DiGiovanni J. Role of cytochrome P4501 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis Chemical Research in Toxicology. 17: 1667-1674. PMID 15606143 DOI: 10.1021/Tx049919C  0.366
2004 Nelson DR, Nebert DW. The truth about mouse, human, worms and yeast. Human Genomics. 1: 146-9. PMID 15601543 DOI: 10.1186/1479-7364-1-2-146  0.352
2004 Nebert DW, Sophos NA, Vasiliou V, Nelson DR. Cyclophilin nomenclature problems, or, 'a visit from the sequence police'. Human Genomics. 1: 381-8. PMID 15588499 DOI: 10.1186/1479-7364-1-5-381  0.35
2004 Dalton TP, Chen Y, Schneider SN, Nebert DW, Shertzer HG. Genetically altered mice to evaluate glutathione homeostasis in health and disease. Free Radical Biology & Medicine. 37: 1511-26. PMID 15477003 DOI: 10.1016/J.Freeradbiomed.2004.06.040  0.348
2004 Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 14: 1-18. PMID 15128046 DOI: 10.1097/00008571-200401000-00001  0.378
2004 Zhang K, Zhang S, Zheng K, Hou Y, Liao L, He Y, Zhang L, Nebert DW, Shi J, Su Z, Xiao C. Novel P143L polymorphism of the LCAT gene is associated with dyslipidemia in Chinese patients who have coronary atherosclerotic heart disease. Biochemical and Biophysical Research Communications. 318: 4-10. PMID 15110745 DOI: 10.1016/J.Bbrc.2004.03.177  0.331
2004 Uno S, Dalton TP, Derkenne S, Curran CP, Miller ML, Shertzer HG, Nebert DW. Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation. Molecular Pharmacology. 65: 1225-37. PMID 15102951 DOI: 10.1124/Mol.65.5.1225  0.746
2004 Uno S, Dalton TP, Sinclair PR, Gorman N, Wang B, Smith AG, Miller ML, Shertzer HG, Nebert DW. Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria. Toxicology and Applied Pharmacology. 196: 410-21. PMID 15094312 DOI: 10.1016/J.Taap.2004.01.014  0.375
2004 Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. The Journal of Biological Chemistry. 279: 23847-50. PMID 15028720 DOI: 10.1074/Jbc.R400004200  0.44
2004 Shertzer HG, Clay CD, Genter MB, Schneider SN, Nebert DW, Dalton TP. Cyp1a2 protects against reactive oxygen production in mouse liver microsomes. Free Radical Biology & Medicine. 36: 605-17. PMID 14980704 DOI: 10.1016/J.Freeradbiomed.2003.11.013  0.317
2004 Nebert DW, Jorge-Nebert L, Vesell ES. Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 3: 361-70. PMID 14672516 DOI: 10.2165/00129785-200303060-00002  0.304
2003 Uno S, Wang B, Shertzer HG, Nebert DW, Dalton TP. Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele. Biochemical and Biophysical Research Communications. 312: 494-9. PMID 14637164 DOI: 10.1016/J.Bbrc.2003.10.145  0.4
2003 Tsuneoka Y, Dalton TP, Miller ML, Clay CD, Shertzer HG, Talaska G, Medvedovic M, Nebert DW. 4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice. Journal of the National Cancer Institute. 95: 1227-37. PMID 12928348 DOI: 10.1093/Jnci/Djg025  0.406
2003 Dieter MZ, Freshwater SL, Miller ML, Shertzer HG, Dalton TP, Nebert DW. Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress. Free Radical Biology & Medicine. 35: 351-67. PMID 12899938 DOI: 10.1016/S0891-5849(03)00273-9  0.759
2003 Smith AG, Davies R, Dalton TP, Miller ML, Judah D, Riley J, Gant T, Nebert DW. Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse. Ehp Toxicogenomics : Journal of the National Institute of Environmental Health Sciences. 111: 45-51. PMID 12735109  0.353
2003 Nichols RC, Cooper S, Trask HW, Gorman N, Dalton TP, Nebert DW, Sinclair JF, Sinclair PR. Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: Relation to the role of CYP1A2 in human porphyria cutanea tarda Biochemical Pharmacology. 65: 545-550. PMID 12566081 DOI: 10.1016/S0006-2952(02)01550-2  0.379
2003 Nebert DW. Transcription factors and cancer: an overview. Toxicology. 131-41. PMID 12505298 DOI: 10.1016/S0300-483X(02)00269-X  0.37
2003 Su Z, Zhang S, Nebert DW, Zhang L, Huang D, Hou Y, Liao L, Xiao C. A novel allele in the promoter of the hepatic lipase is associated with increased concentration of HDL-C and decreased promoter activity. Journal of Lipid Research. 43: 1595-601. PMID 12364543 DOI: 10.1194/Jlr.M200046-Jlr200  0.319
2002 Nebert DW. Proposal for an allele nomenclature system based on the evolutionary divergence of haplotypes. Human Mutation. 20: 463-72. PMID 12442271 DOI: 10.1002/Humu.10143  0.349
2002 Senft AP, Dalton TP, Nebert DW, Genter MB, Puga A, Hutchinson RJ, Kerzee JK, Uno S, Shertzer HG. Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free Radical Biology & Medicine. 33: 1268-78. PMID 12398935 DOI: 10.1016/S0891-5849(02)01014-6  0.371
2002 Nebert DW, Russell DW. Clinical importance of the cytochromes P450 Lancet. 360: 1155-1162. PMID 12387968 DOI: 10.1016/S0140-6736(02)11203-7  0.38
2002 Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, Dalton TP. Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response. The Journal of Biological Chemistry. 277: 49446-52. PMID 12384496 DOI: 10.1074/Jbc.M209372200  0.774
2002 Shertzer HG, Dalton TP, Talaska G, Nebert DW. Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice. Toxicology and Applied Pharmacology. 181: 32-7. PMID 12030840 DOI: 10.1006/Taap.2002.9398  0.418
2002 Solis WA, Dalton TP, Dieter MZ, Freshwater S, Harrer JM, He L, Shertzer HG, Nebert DW. Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress. Biochemical Pharmacology. 63: 1739-54. PMID 12007577 DOI: 10.1016/S0006-2952(02)00897-3  0.791
2002 Gorman N, Ross KL, Walton HS, Bement WJ, Szakacs JG, Gerhard GS, Dalton TP, Nebert DW, Eisenstein RS, Sinclair JF, Sinclair PR. Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron. Hepatology (Baltimore, Md.). 35: 912-21. PMID 11915039 DOI: 10.1053/Jhep.2002.32487  0.342
2002 Nebert DW, Menon AG. Pharmacogenomics, ethnicity, and susceptibility genes. The Pharmacogenomics Journal. 1: 19-22. PMID 11913722 DOI: 10.1038/Sj.Tpj.6500002  0.348
2002 Nebert DW, Roe AL, Vandale SE, Bingham E, Oakley GG. NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 4: 62-70. PMID 11882782 DOI: 10.1097/00125817-200203000-00003  0.364
2002 Solis WA, Childs NL, Weedon MN, He L, Nebert DW, Dalton TP. Retrovirally expressed metal response element-binding transcription factor-1 normalizes metallothionein-1 gene expression and protects cells against zinc, but not cadmium, toxicity. Toxicology and Applied Pharmacology. 178: 93-101. PMID 11814329 DOI: 10.1006/Taap.2001.9319  0.797
2002 Nebert DW, Stuart GW, Solis WA, Carvan MJ. Use of reporter genes and vertebrate DNA motifs in transgenic zebrafish as sentinels for assessing aquatic pollution. Environmental Health Perspectives. 110: A15. PMID 11813700  0.768
2002 Senft AP, Dalton TP, Nebert DW, Genter MB, Hutchinson RJ, Shertzer HG. Dioxin increases reactive oxygen production in mouse liver mitochondria. Toxicology and Applied Pharmacology. 178: 15-21. PMID 11781075 DOI: 10.1006/Taap.2001.9314  0.306
2002 Smith AG, Davies R, Dalton TP, Miller ML, Judah DJ, Riley J, Gant TW, Nebert DW. Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse. Environmental Health Perspectives. 111: 855-856. DOI: 10.1289/Ehp.111-1241507  0.459
2002 Dieter MZ, Freshwater SL, Solis WA, Nebert DW, Dalton TP. Tryphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements Biochemical Pharmacology. 64: 215-225. DOI: 10.1016/S0006-2952(02)01230-3  0.79
2001 Uno S, Dalton TP, Shertzer HG, Genter MB, Warshawsky D, Talaska G, Nebert DW. Benzo[a]pyrene-induced toxicity: Paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels Biochemical and Biophysical Research Communications. 289: 1049-1056. PMID 11741297 DOI: 10.1006/Bbrc.2001.6110  0.425
2001 Smith AG, Clothier B, Carthew P, Childs NL, Sinclair PR, Nebert DW, Dalton TP. Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology and Applied Pharmacology. 173: 89-98. PMID 11384210 DOI: 10.1006/Taap.2001.9167  0.401
2001 Zaccaro C, Sweitzer S, Pipino S, Gorman N, Sinclair PR, Sinclair JF, Nebert DW, De Matteis F. Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice. Biochemical Pharmacology. 61: 843-9. PMID 11274970 DOI: 10.1016/S0006-2952(01)00568-8  0.381
2001 Dieter MZ, Freshwater SL, Solis WA, Nebert DW, Dalton TP. Tyrphostin [correction of Tryphostin] AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements. Biochemical Pharmacology. 61: 215-25. PMID 11163336  0.791
2001 Nebert DW. Extreme discordant phenotype methodology: an intuitive approach to clinical pharmacogenetics. European Journal of Pharmacology. 410: 107-120. PMID 11134663 DOI: 10.1016/S0014-2999(00)00809-8  0.354
2001 Nebert DW. Drug-metabolizing enzymes, polymorphisms and interindividual response to environmental toxicants. Clinical Chemistry and Laboratory Medicine. 38: 857-61. PMID 11097340 DOI: 10.1515/Cclm.2000.124  0.407
2001 Nebert DW, Roe AL. Ecogenetics: The Study of Gene–Environment Interactions Patty's Toxicology. DOI: 10.1002/0471435139.Tox007  0.347
2000 Sinclair PR, Gorman N, Walton HS, Bement WJ, Szakacs J, Gonzalez FJ, Dalton TP, Nebert DW, Sinclair JF. Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone. Archives of Biochemistry and Biophysics. 384: 383-90. PMID 11368328 DOI: 10.1006/Abbi.2000.2124  0.339
2000 Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW. Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: Embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous Biochemical and Biophysical Research Communications. 279: 324-329. PMID 11118286 DOI: 10.1006/Bbrc.2000.3930  0.781
2000 Nebert DW, Dalton TP, Stuart GW, Carvan MJ. "Gene-swap knock-in" cassette in mice to study allelic differences in human genes. Annals of the New York Academy of Sciences. 919: 148-70. PMID 11083106 DOI: 10.1111/J.1749-6632.2000.Tb06876.X  0.442
2000 Carvan MJ, Dalton TP, Stuart GW, Nebert DW. Transgenic zebrafish as sentinels for aquatic pollution. Annals of the New York Academy of Sciences. 919: 133-47. PMID 11083105 DOI: 10.1111/J.1749-6632.2000.Tb06875.X  0.36
2000 Dalton TP, Solis WA, Nebert DW, Carvan MJ. Characterization of the MTF-1 transcription factor from zebrafish and trout cells. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 126: 325-35. PMID 11007174 DOI: 10.1016/S0305-0491(00)00182-6  0.785
2000 Nebert DW, Dieter MZ. The evolution of drug metabolism. Pharmacology. 61: 124-35. PMID 10971198 DOI: 10.1159/000028393  0.778
2000 Nebert DW. Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology. Pharmacogenetics. 10: 279-90. PMID 10862518 DOI: 10.1097/00008571-200006000-00001  0.366
2000 Carvan MJ, Solis WA, Gedamu L, Nebert DW. Activation of transcription factors in zebrafish cell cultures by environmental pollutants. Archives of Biochemistry and Biophysics. 376: 320-7. PMID 10775418 DOI: 10.1006/Abbi.2000.1727  0.798
2000 Dalton TP, Miller ML, Wu X, Menon A, Cianciolo E, McKinnon RA, Smith PW, Robinson LJ, Nebert DW. Refining the mouse chromosomal location of Cdm, the major gene associated with susceptibility to cadmium-induced testicular necrosis. Pharmacogenetics. 10: 141-51. PMID 10762002 DOI: 10.1097/00008571-200003000-00006  0.404
2000 Ingelman-Sundberg M, Daly AK, Oscarson M, Nebert DW. Human cytochrome P450 (CYP) genes: recommendations for the nomenclature of alleles. Pharmacogenetics. 10: 91-3. PMID 10739177 DOI: 10.1097/00008571-200002000-00012  0.383
2000 Vasiliou V, Buetler T, Eaton DL, Nebert DW. Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines Biochemical Pharmacology. 59: 703-712. PMID 10677587 DOI: 10.1016/S0006-2952(99)00360-3  0.365
2000 Nebert DW. Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist? Clinical Genetics. 56: 247-58. PMID 10636440 DOI: 10.1034/J.1399-0004.1999.560401.X  0.354
2000 Sinclair PR, Gorman N, Walton HS, Bement WJ, Dalton TP, Sinclair JF, Smith AG, Nebert DW. CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron. Toxicology and Applied Pharmacology. 162: 60-7. PMID 10631128 DOI: 10.1006/Taap.1999.8832  0.376
2000 Dalton TP, Dieter MZ, Matlib RS, Childs NL, Shertzer HG, Genter MB, Nebert DW. Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery Biochemical and Biophysical Research Communications. 267: 184-189. PMID 10623596 DOI: 10.1006/Bbrc.1999.1913  0.801
2000 Nebert DW, Roe AL, Dieter MZ, Solis WA, Yang Y, Dalton TP. Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis. Biochemical Pharmacology. 59: 65-85. PMID 10605936 DOI: 10.1016/S0006-2952(99)00310-X  0.8
1999 Shertzer HG, Puga A, Chang CY, Smith P, Nebert DW, Setchell KDR, Dalton TP. Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones Chemico-Biological Interactions. 123: 31-49. PMID 10597900 DOI: 10.1016/S0009-2797(99)00121-0  0.362
1999 Vasiliou V, Reuter SF, Williams S, Puga A, Nebert DW. Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): Gene structure and regulation of constitutive and dioxin-inducible expression Pharmacogenetics. 9: 569-580. PMID 10591537 DOI: 10.1097/00008571-199910000-00004  0.448
1999 Dey A, Jones JE, Nebert DW. Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization. Biochemical Pharmacology. 58: 525-37. PMID 10424773 DOI: 10.1016/S0006-2952(99)00110-0  0.362
1999 Carvan MJ, Ponomareva LV, Solis WA, Matlib RS, Puga A, Nebert DW. Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins. Marine Biotechnology (New York, N.Y.). 1: 155-166. PMID 10373624 DOI: 10.1007/Pl00011763  0.817
1999 Nebert DW, Ingelman-Sundberg M, Daly AK. Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues. Drug Metabolism Reviews. 31: 467-87. PMID 10335448 DOI: 10.1081/Dmr-100101931  0.374
1998 DiRocco L, Dalton T, Liang D, Nebert DW, Seyfried TN. Nonallelism for the audiogenic seizure prone (Asp1) and the aryl hydrocarbon receptor (Ahr) loci in mice. Journal of Neurogenetics. 12: 191-203. PMID 10656108 DOI: 10.3109/01677069809108558  0.334
1998 Tonge RP, Kelly EJ, Bruschi SA, Kalhorn T, Eaton DL, Nebert DW, Nelson SD. Role of CYP1A2 in the hepatotoxicity of acetaminophen: Investigations using Cyp1a2 null mice Toxicology and Applied Pharmacology. 153: 102-108. PMID 9875304 DOI: 10.1006/Taap.1998.8543  0.395
1998 Shertzer HG, Nebert DW, Puga A, Ary M, Sonntag D, Dixon K, Robinson LJ, Cianciolo E, Dalton TP. Dioxin causes a sustained oxidative stress response in the mouse Biochemical and Biophysical Research Communications. 253: 44-48. PMID 9875217 DOI: 10.1006/Bbrc.1998.9753  0.333
1998 Dey A, Nebert DW. Markedly increased constitutive CYP1A1 mRNA levels in the fertilized ovum of the mouse. Biochemical and Biophysical Research Communications. 251: 657-61. PMID 9792830 DOI: 10.1006/Bbrc.1998.9519  0.376
1998 McKinnon RA, Nebert DW. Cytochrome P450 knockout mice: New toxicological models Clinical and Experimental Pharmacology and Physiology. 25: 783-787. PMID 9784916 DOI: 10.1111/J.1440-1681.1998.Tb02153.X  0.415
1998 Fitzgerald CT, Nebert DW, Puga A. Regulation of mouse Ah receptor (Ahr) gene basal expression by members of the Sp family of transcription factors Dna and Cell Biology. 17: 811-822. PMID 9778040 DOI: 10.1089/Dna.1998.17.811  0.323
1998 Genter MB, Liang HC, Gu J, Ding X, Negishi M, McKinnon RA, Nebert DW. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1A2(-/-)mouse Biochemical Pharmacology. 55: 1819-1826. PMID 9714300 DOI: 10.1016/S0006-2952(98)00004-5  0.365
1998 Vorhees CV, Reed TM, Schilling MA, Fisher JE, Moran MS, Cappon GD, Nebert DW. CYP2D1 polymorphism in methamphetamine-treated rats: genetic differences in neonatal mortality and effects on spatial learning and acoustic startle. Neurotoxicology and Teratology. 20: 265-73. PMID 9638684 DOI: 10.1016/S0892-0362(97)00129-3  0.306
1998 Maier A, Micka J, Miller K, Denko T, Chang CY, Nebert DW, Alvaro Puga. Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype. Environmental Health Perspectives. 106: 421-6. PMID 9637800 DOI: 10.1289/Ehp.106-1533118  0.369
1998 Yu M, Jamieson GA, Leikauf GD, Nebert DW. Phospholipase A2 activation and increases in specific prostaglandins in the oxidatively stressed 14CoS/14CoS mouse hepatocyte line. Biochemical Pharmacology. 55: 193-200. PMID 9448742 DOI: 10.1016/S0006-2952(97)00418-8  0.316
1997 Liang HCL, McKinnon RA, Nebert DW. Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in cyp1a2(+/+) wild type and cyp1a2(-/-) null mutant mice Biochemical Pharmacology. 54: 1127-1131. PMID 9464455 DOI: 10.1016/S0006-2952(97)00263-3  0.425
1997 Roberts RA, Nebert DW, Hickman JA, Richburg JH, Goldsworthy TL. Perturbation of the mitosis/apoptosis balance: a fundamental mechanism in toxicology. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 38: 107-15. PMID 9299183 DOI: 10.1006/Faat.1997.2331  0.355
1997 Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, ... ... Nebert DW, et al. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics. 7: 255-69. PMID 9295054 DOI: 10.1097/00008571-199708000-00001  0.394
1997 Micka J, Milatovich A, Menon A, Grabowski GA, Puga A, Nebert DW. Human Ah receptor (AHR) gene: Localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility Pharmacogenetics. 7: 95-101. PMID 9170146 DOI: 10.1097/00008571-199704000-00002  0.474
1997 Vasiliou V, Reuter SF, Nebert DW. Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1α mRNAs in ch/ch and 14CoS/14CoS mice Biochemical and Biophysical Research Communications. 233: 631-636. PMID 9168903 DOI: 10.1006/Bbrc.1997.6384  0.351
1997 Puga A, Nebert DW, McKinnon RA, Menon AG. Genetic polymorphisms in human drug-metabolizing enzymes: Potential uses of reverse genetics to identify genes of toxicological relevance Critical Reviews in Toxicology. 27: 199-222. PMID 9099519 DOI: 10.3109/10408449709021619  0.367
1997 Nebert DW, Duffy JJ. How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress. Biochemical Pharmacology. 53: 249-54. PMID 9065727 DOI: 10.1016/S0006-2952(96)00740-X  0.432
1996 Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 6: 1-42. PMID 8845856 DOI: 10.1097/00008571-199602000-00002  0.384
1996 FitzGerald CT, Fernandez-Salguero P, Gonzalez FJ, Nebert DW, Puga A. Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins Archives of Biochemistry and Biophysics. 333: 170-178. PMID 8806768 DOI: 10.1006/Abbi.1996.0378  0.394
1996 Liang HCL, Li H, Mckinnon RA, Duffy JJ, Potter SS, Puga A, Nebert DW. Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism Proceedings of the National Academy of Sciences of the United States of America. 93: 1671-1676. PMID 8643688 DOI: 10.1073/Pnas.93.4.1671  0.452
1996 Nebert DW, McKinnon RA, Puga A. Human drug-metabolizing enzyme polymorphisms: Effects on risk of toxicity and cancer Dna and Cell Biology. 15: 273-280. PMID 8639263 DOI: 10.1089/Dna.1996.15.273  0.403
1996 Vasiliou V, Kozak CA, Lindahl R, Nebert DW. Mouse microsomal Class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping. Dna and Cell Biology. 15: 235-45. PMID 8634152 DOI: 10.1089/Dna.1996.15.235  0.416
1996 Miller MS, Juchau MR, Guengerich FP, Nebert DW, Raucy JL. Drug Metabolic Enzymes in Developmental Toxicology Toxicological Sciences. 34: 165-175. DOI: 10.1093/Toxsci/34.2.165  0.371
1995 Vasiliou V, Puga A, Chang CY, Tabor MW, Nebert DW. Interaction between the Ah receptor and proteins binding to the AP-1-like electrophile response element (EpRE) during murine phase II [Ah] battery gene expression Biochemical Pharmacology. 50: 2057-2068. PMID 8849333 DOI: 10.1016/0006-2952(95)02108-6  0.41
1995 Vasiliou V, Shertzer HG, Liu RM, Sainsbury M, Nebert DW. Response of [Ah] battery genes to compounds that protect against menadione toxicity Biochemical Pharmacology. 50: 1885-1891. PMID 8615869 DOI: 10.1016/0006-2952(95)02083-7  0.451
1995 Duh JL, Zhu H, Shertzer HG, Nebert DW, Puga A. The Y-box motif mediates redox-dependent transcriptional activation in mouse cells Journal of Biological Chemistry. 270: 30499-30507. PMID 8530481 DOI: 10.1074/Jbc.270.51.30499  0.375
1995 Fernandez-Salguero P, Pineau T, Hilbert DM, McPhail T, Lee SS, Kimura S, Nebert DW, Rudikoff S, Ward JM, Gonzalez FJ. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science (New York, N.Y.). 268: 722-6. PMID 7732381 DOI: 10.1126/Science.7732381  0.4
1995 Vasiliou V, Reuter SF, Kozak CA, Nebert DW. Mouse class 3 aldehyde dehydrogenases. Advances in Experimental Medicine and Biology. 372: 151-8. PMID 7484373 DOI: 10.1007/978-1-4615-1965-2_20  0.407
1995 Shertzer HG, Vasiliou V, Liu RM, Tabor MW, Nebert DW. Enzyme induction by l-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells Chemical Research in Toxicology. 8: 431-436. DOI: 10.1021/Tx00045A015  0.384
1994 Nebert DW. Drug-metabolizing enzymes in ligand-modulated transcription. Biochemical Pharmacology. 47: 25-37. PMID 8311842 DOI: 10.1016/0006-2952(94)90434-0  0.386
1994 Pappas P, Vasiliou V, Nebert DW, Marselos M. Lack of response of the rat liver "class 3" cytosolic aldehyde dehydrogenase to toxic chemicals, glutathione depletion, and other forms of stress Biochemical Pharmacology. 48: 841-845. PMID 8080457 DOI: 10.1016/0006-2952(94)90064-7  0.344
1994 Carrier F, Chang CY, Duh JL, Nebert DW, Puga A. Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT) Biochemical Pharmacology. 48: 1767-1778. PMID 7980646 DOI: 10.1016/0006-2952(94)90463-4  0.377
1994 Liu RM, Vasiliou V, Zhu H, Duh JL, Tabor MW, Puga A, Nebert DW, Sainsbury M, Shertzer HG. Regulation of [ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[l,2-b]indole in mouse hepatoma cell lines Carcinogenesis. 15: 2347-2352. PMID 7955076 DOI: 10.1093/Carcin/15.10.2347  0.417
1994 Jorge LF, Arias TD, Griese U, Nebert DW, Eichelbaum M. Evolutionary pharmacogenetics of CYP2D6 in Ngawbe Guaymi of Panama: allele-specific PCR detection of the CYP2D6B allele and RFLP analysis. Pharmacogenetics. 3: 231-8. PMID 7904509 DOI: 10.1097/00008571-199310000-00002  0.329
1994 Vasiliou V, Theurer MJ, Puga A, Reuter SF, Nebert DW. Mouse dioxin-inducible NAD(P)H: Menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels Pharmacogenetics. 4: 341-348. PMID 7704040 DOI: 10.1097/00008571-199412000-00007  0.452
1994 McKinnon RA, Nebert DW. Possible role of cytochromes P450 in lupus erythematosus and related disorders Lupus. 3: 473-478. PMID 7704004 DOI: 10.1177/096120339400300608  0.4
1994 Wedlund PJ, Kimura S, Gonzalez FJ, Nebert DW. 1462V mutation in the human CYP1A1 gene Pharmacogenetics. 4: 21-26. DOI: 10.1097/00008571-199402000-00003  0.4
1993 Vasiliou V, Puga A, Nebert DW. Mouse class 3 aldehyde dehydrogenases: Positive and negative regulation of gene expression Advances in Experimental Medicine and Biology. 328: 131-140. PMID 8493891 DOI: 10.1007/978-1-4615-2904-0_15  0.375
1993 Nebert DW, Puga A, Vasiliou V. Roel of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction Annals of the New York Academy of Sciences. 685: 624-640. PMID 8395783 DOI: 10.1111/J.1749-6632.1993.Tb35928.X  0.473
1993 Pilon AL, Kozak CA, Nebert DW, Puga A. Localization of the murine Hmg1 gene, encoding an HMG-box protein, to mouse Chromosome 2 Mammalian Genome. 4: 612-614. PMID 8268661 DOI: 10.1007/Bf00361395  0.355
1993 Chang CY, Smith DR, Prasad VS, Sidman CL, Nebert DW, Puga A. Ten nucleotide differences, five of which cause amino acid changes, are associated with the ah receptor locus polymorphism of c57bl/6 and DBA/2 mice Pharmacogenetics. 3: 312-321. PMID 8148872 DOI: 10.1097/00008571-199312000-00005  0.319
1993 Vasiliou V, Reuter SF, Kozak CA, Nebert DW. Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mrna levels Pharmacogenetics. 3: 281-290. PMID 8148869 DOI: 10.1097/00008571-199312000-00002  0.428
1993 Tefre T, Ryberg D, Haugen A, Nebert DW, Skaug V, Brøgger A, Børresen AL. Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population. Pharmacogenetics. 1: 20-5. PMID 1726950 DOI: 10.1097/00008571-199110000-00004  0.306
1992 Nebert DW. Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions. Molecular Endocrinology (Baltimore, Md.). 5: 1203-14. PMID 1663211 DOI: 10.1210/Mend-5-9-1203  0.349
1992 Puga A, Nebert DW, Carrier F. Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1 Dna and Cell Biology. 11: 269-281. PMID 1605850 DOI: 10.1089/Dna.1992.11.269  0.324
1992 Liang HCL, Shertzer HG, Nebert DW. "Oxidative stress" response in liver of an untreated newborn mouse having a 1.2-centimorgan deletion on chromosome 7 Biochemical and Biophysical Research Communications. 182: 1160-1165. PMID 1540161 DOI: 10.1016/0006-291X(92)91853-I  0.393
1992 Vasiliou V, Puga A, Nebert DW. Negative regulation of the murine cytosolic aldehyde dehydrogenase-3 (Aldh-3c) gene by functional CYP1A1 and CYP1A2 proteins Biochemical and Biophysical Research Communications. 187: 413-419. PMID 1520328 DOI: 10.1016/S0006-291X(05)81508-6  0.457
1992 Carrier F, Owens RA, Nebert DW, Puga A. Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation. Molecular and Cellular Biology. 12: 1856-63. PMID 1312672 DOI: 10.1128/Mcb.12.4.1856  0.363
1992 Puga A, Raychaudhuri B, Nebert DW. Transcriptional derepression of the murine Cyp1a-1 gene by mevinolin Faseb Journal. 6: 777-785. PMID 1311272 DOI: 10.1096/Fasebj.6.2.1311272  0.453
1991 Nebert DW, Petersen DD, Fornace AJ. Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm. Environmental Health Perspectives. 88: 13-25. PMID 2272308 DOI: 10.1289/Ehp.908813  0.434
1991 Gonzalez FJ, Liu SY, Kozak CA, Nebert DW. Decreased Hnf-1 gene expression in mice homozygous for a 1.2-centiMorgan deletion on chromosome 7. Dna and Cell Biology. 9: 771-6. PMID 2264930 DOI: 10.1089/Dna.1990.9.771  0.413
1991 Teeter LD, Petersen DD, Nebert DW, Kuo MT. Murine mdr-1, mdr-2, and mdr-3 gene expression: no coinduction with the Cyp1a-1 and Nmo-1 genes in liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Dna and Cell Biology. 10: 433-41. PMID 2069718 DOI: 10.1089/Dna.1991.10.433  0.409
1991 Nebert DW. Role of genetics and drug metabolism in human cancer risk. Mutation Research. 247: 267-81. PMID 2011144 DOI: 10.1016/0027-5107(91)90022-G  0.348
1991 Nebert DW, Nelson DR, Coon MJ, Estabrook RW, Feyereisen R, Fujii-Kuriyama Y, Gonzalez FJ, Guengerich FP, Gunsalus IC, Johnson EF. The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. Dna and Cell Biology. 10: 1-14. PMID 1991046 DOI: 10.1089/Dna.1991.10.1  0.375
1991 Haque SJ, Petersen DD, Nebert DW, Mackenzie PI. Isolation, sequence, and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP glucuronosyltransferase that metabolizes etiocholanolone and androsterone. Dna and Cell Biology. 10: 515-24. PMID 1909872 DOI: 10.1089/Dna.1991.10.515  0.374
1991 Burchell B, Nebert DW, Nelson DR, Bock KW, Iyanagi T, Jansen PL, Lancet D, Mulder GJ, Chowdhury JR, Siest G. The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence. Dna and Cell Biology. 10: 487-94. PMID 1909870 DOI: 10.1089/Dna.1991.10.487  0.388
1991 Shaw PM, Reiss A, Adesnik M, Nebert DW, Schembri J, Jaiswal AK. The human dioxin-inducible NAD(P)H: quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4. European Journal of Biochemistry / Febs. 195: 171-6. PMID 1899380 DOI: 10.1111/J.1432-1033.1991.Tb15691.X  0.37
1991 Nebert DW, Petersen DD, Puga A. Human AH locus polymorphism and cancer inducibility of CYP1A1 and other genes by combustion products and dioxin Pharmacogenetics. 1: 68-78. PMID 1844873 DOI: 10.1097/00008571-199111000-00003  0.457
1991 Dey A, Nebert DW, Ozato K. The AP-1 site and the cAMP- and serum response elements of the c-fos gene are constitutively occupied in vivo Dna and Cell Biology. 10: 537-544. PMID 1832543 DOI: 10.1089/Dna.1991.10.537  0.356
1991 Nebert DW, Nelson DR. P450 gene nomenclature based on evolution Methods in Enzymology. 206: 3-11. PMID 1784216 DOI: 10.1016/0076-6879(91)06072-B  0.406
1991 Petersen DD, Kong AT, Jorge LF, Nebert DW, Arias TD. Debrisoquine polymorphism Pharmacogenetics. 1: 136. DOI: 10.1097/00008571-199112000-00003  0.339
1990 Bigelow SW, Nebert DW. The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines. Journal of Biochemical Toxicology. 1: 1-14. PMID 2856069 DOI: 10.1002/Jbt.2570010103  0.38
1990 Puga A, Raychaudhuri B, Salata K, Zhang YH, Nebert DW. Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity Dna and Cell Biology. 9: 425-436. PMID 2206399 DOI: 10.1089/Dna.1990.9.425  0.453
1990 Gonzalez FJ, Nebert DW. Evolution of the P450 gene superfamily:. animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation Trends in Genetics. 6: 182-186. PMID 2196721 DOI: 10.1016/0168-9525(90)90174-5  0.4
1990 Puga A, Nebert DW. Evolution of the P450 gene superfamily and regulation of the murine Cyp1a1 gene Biochemical Society Transactions. 18: 7-10. PMID 2185093 DOI: 10.1042/Bst0180007  0.413
1990 Owens RA, Nebert DW. Expression of the chloramphenicol acetyltransferase (CAT) reporter gene by the murine Cyp1a-2 (cytochrome P3(450)) promoter in hepatoma cell cultures. Biochemical and Biophysical Research Communications. 172: 1109-15. PMID 2173915 DOI: 10.1016/0006-291X(90)91561-6  0.438
1990 RayChaudhuri B, Nebert DW, Puga A. The murine Cyp1a-1 gene negatively regulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery Molecular Endocrinology. 4: 1773-1781. PMID 2082180 DOI: 10.1210/Mend-4-12-1773  0.443
1989 Kouri RR, Ratrie H, Atlas SA, Niwa A, Nebert DW. Aryl hydrocarbon hydroxylase induction in human lymphocyte cultures by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Life Sciences. 15: 1585-95. PMID 4549995 DOI: 10.1016/0024-3205(74)90324-5  0.373
1989 Nebert DW, Nelson DR, Feyereisen R. Evolution of the cytochrome P450 genes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 19: 1149-60. PMID 2683414 DOI: 10.3109/00498258909043167  0.406
1989 Ikeya K, Jaiswal AK, Owens RA, Jones JE, Nebert DW, Kimura S. Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. Molecular Endocrinology (Baltimore, Md.). 3: 1399-408. PMID 2575218 DOI: 10.1210/Mend-3-9-1399  0.436
1989 Fornace AJ, Nebert DW, Hollander MC, Luethy JD, Papathanasiou M, Fargnoli J, Holbrook NJ. Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Molecular and Cellular Biology. 9: 4196-203. PMID 2573827 DOI: 10.1128/Mcb.9.10.4196  0.37
1989 Nebert DW. The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects Critical Reviews in Toxicology. 20: 153-174. PMID 2558673 DOI: 10.3109/10408448909017908  0.42
1989 Neuhold LA, Shirayoshi Y, Ozato K, Jones JE, Nebert DW. Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction Molecular and Cellular Biology. 9: 2378-2386. PMID 2548080 DOI: 10.1128/Mcb.9.6.2378  0.394
1989 Nebert DW, Jones JE. Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene. The International Journal of Biochemistry. 21: 243-52. PMID 2545475 DOI: 10.1016/0020-711X(89)90182-1  0.41
1989 Petersen DD, Gonzalez FJ, Rapic V, Kozak CA, Lee JY, Jones JE, Nebert DW. Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion. Proceedings of the National Academy of Sciences of the United States of America. 86: 6699-703. PMID 2505256 DOI: 10.1073/Pnas.86.17.6699  0.456
1989 Dey A, Westphal H, Nebert DW. Cell-specific induction of mouse Cyp1a1 mRNA during development. Proceedings of the National Academy of Sciences of the United States of America. 86: 7446-50. PMID 2477842 DOI: 10.1073/PNAS.86.19.7446  0.364
1988 Nebert DW, Jaiswal AK, Meyer UA, Gonzalez FJ. Human P-450 genes: evolution, regulation and possible role in carcinogenesis. Biochemical Society Transactions. 15: 586-9. PMID 3678581 DOI: 10.1042/Bst0150586  0.377
1988 Jaiswal AK, Gonzalez FJ, Nebert DW. Comparison of human mouse P1450 upstream regulatory sequences in liver- and nonliver-derived cell lines. Molecular Endocrinology (Baltimore, Md.). 1: 312-20. PMID 3453896 DOI: 10.1210/Mend-1-4-312  0.389
1988 Gonzalez FJ, Vilbois F, Hardwick JP, McBride OW, Nebert DW, Gelboin HV, Meyer UA. Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22 Genomics. 2: 174-179. PMID 3410476 DOI: 10.1016/0888-7543(88)90100-0  0.313
1988 Gonzalez FJ, Skoda RC, Kimura S, Umeno M, Zanger UM, Nebert DW, Gelboin HV, Hardwick JP, Meyer UA. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism Nature. 331: 442-446. PMID 3123997 DOI: 10.1038/331442A0  0.391
1988 Nebert DW. Genes encoding drug-metabolizing enzymes: possible role in human disease. Basic Life Sciences. 43: 45-64. PMID 2896496 DOI: 10.1007/978-1-4684-5460-4_6  0.326
1987 Gonzalez FJ, Jaiswal AK, Nebert DW. P450 genes: evolution, regulation, and relationship to human cancer and pharmacogenetics. Cold Spring Harbor Symposia On Quantitative Biology. 879-90. PMID 3472766 DOI: 10.1101/SQB.1986.051.01.101  0.326
1987 Nebert DW, Gonzalez FJ. P450 genes: structure, evolution, and regulation Annual Review of Biochemistry. 56: 945-993. PMID 3304150 DOI: 10.1146/Annurev.Bi.56.070187.004501  0.351
1987 Krasnewich D, Kozak CA, Nebert DW, Mackenzie PI. Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5. Somatic Cell and Molecular Genetics. 13: 179-82. PMID 3105095 DOI: 10.1007/Bf01534698  0.388
1987 Neuhold LA, Gonzalez FJ, Jaiswal AK, Nebert DW. Dioxin-inducible enhancer region upstream from the mouse P(1)450 gene and interaction with a heterologous SV40 promoter. Dna (Mary Ann Liebert, Inc.). 5: 403-11. PMID 3023000 DOI: 10.1089/dna.1986.5.403  0.306
1987 Jaiswal AK, Neuhold LA, Nebert DW. Human P45IA1 upstream regulatory sequences expressing the chloramphenicol acetyltransferase gene. Effect of Ha-MSV enhancer and comparison of transient with stable transformation assays. Biochemical and Biophysical Research Communications. 148: 857-63. PMID 2825673 DOI: 10.1016/0006-291X(87)90954-5  0.346
1986 Kimura S, Nebert DW. Comparison of the mouse P(1)450 gene and flanking sequences from a MOPC 41 plasmacytoma and normal liver. Dna (Mary Ann Liebert, Inc.). 4: 365-75. PMID 4075955 DOI: 10.1089/DNA.1985.4.365  0.314
1986 Kimura S, Nebert DW. cDNA and complete amino acid sequence of mouse P2(450): allelic variant of mouse P3(450) gene. Nucleic Acids Research. 14: 6765-6. PMID 3755821 DOI: 10.1093/Nar/14.16.6765  0.349
1986 Jaiswal AK, Nebert DW. Two RFLPs associated with the human P1450 gene linked to the MPI locus on chromosome 15 [HGM8 D15S8]. Nucleic Acids Research. 14: 4376. PMID 3714481 DOI: 10.1093/Nar/14.10.4376  0.332
1986 Peterson TC, Gonzalez FJ, Nebert DW. Methylation differences in the murine P1450 and P3450 genes in wild-type and mutant hepatoma cell culture. Biochemical Pharmacology. 35: 2107-14. PMID 2425809 DOI: 10.1016/0006-2952(86)90577-0  0.362
1985 Tuteja N, Gonzalez FJ, Nebert DW. Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes Developmental Biology. 112: 177-184. PMID 4054433 DOI: 10.1016/0012-1606(85)90131-9  0.395
1985 Hildebrand CE, Gonzalez FJ, Kozak CA, Nebert DW. Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9. Biochemical and Biophysical Research Communications. 130: 396-406. PMID 4040754 DOI: 10.1016/0006-291X(85)90430-9  0.38
1985 Van Cantfort J, Gielen JE, Nebert DW. Benzo[a]pyrene metabolism in mouse liver. Association of both 7,8-epoxidation and covalent binding of a metabolite of the 7,8-diol with the Ah locus. Biochemical Pharmacology. 34: 1821-6. PMID 4039937 DOI: 10.1016/0006-2952(85)90655-0  0.36
1985 Hildebrand CE, Gonzalez FJ, McBride OW, Nebert DW. Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15. Nucleic Acids Research. 13: 2009-16. PMID 4000952 DOI: 10.1093/Nar/13.6.2009  0.361
1985 Jaiswal AK, Gonzalez FJ, Nebert DW. Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. Science (New York, N.Y.). 228: 80-3. PMID 3838385 DOI: 10.1126/Science.3838385  0.376
1985 Gonzalez FJ, Nebert DW. Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P1450 gene Nucleic Acids Research. 13: 7269-7288. PMID 2997746 DOI: 10.1093/Nar/13.20.7269  0.414
1985 Jaiswal AK, Nebert DW, Eisen HW. Comparison of aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase induction by polycyclic aromatic compounds in human and mouse cell lines. Biochemical Pharmacology. 34: 2721-31. PMID 2990496 DOI: 10.1016/0006-2952(85)90573-8  0.367
1985 Jaiswal AK, Gonzalez FJ, Nebert DW. Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism. Nucleic Acids Research. 13: 4503-20. PMID 2989797 DOI: 10.1093/Nar/13.12.4503  0.405
1985 Nebert DW. P450 genes and their regulation Trends in Pharmacological Sciences. 6: 270-273. DOI: 10.1016/0165-6147(85)90124-5  0.375
1985 Nebert DW, Gonzalez FJ. Cytochrome P450 gene expression and regulation Trends in Pharmacological Sciences. 6: 160-164. DOI: 10.1016/0165-6147(85)90075-6  0.36
1984 Nebert DW, Negishi M, Chen YT, Tukey RH. Cloning genes that encode inducible forms of P-450 Biochemical Society Transactions. 12: 99-101. PMID 6705999 DOI: 10.1042/Bst0120099  0.381
1984 Nebert DW, Brown DD, Towne DW, Eisen HJ. Association of fertility, fitness and longevity with the murine Ah locus among (C57BL/6N) (C3H/HeN) recombinant inbred lines. Biology of Reproduction. 30: 363-73. PMID 6704471 DOI: 10.1095/Biolreprod30.2.363  0.323
1984 Lazarte RA, Bigelow SW, Nebert DW, Levitt RC. Effects of cimetidine on theophylline, acetaminophen, and zoxazolamine toxicity in the intact mouse. Developmental Pharmacology and Therapeutics. 7: 21-9. PMID 6697867 DOI: 10.1159/000457140  0.377
1984 Gonzalez FJ, Mackenzie PI, Kimura S, Nebert DW. Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450. Gene. 29: 281-92. PMID 6548461 DOI: 10.1016/0378-1119(84)90057-X  0.358
1984 Kaipainen P, Nebert DW, Lang MA. Purification and characterization of a microsomal cytochrome P-450 with high activity of coumarin 7-hydroxylase from mouse liver European Journal of Biochemistry. 144: 425-431. PMID 6436023 DOI: 10.1111/J.1432-1033.1984.Tb08483.X  0.341
1984 Tukey RH, Nebert DW. Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone Biochemistry. 23: 6003-6008. PMID 6395889 DOI: 10.1021/Bi00320A016  0.397
1984 Tukey RH, Lalley PA, Nebert DW. Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9 Proceedings of the National Academy of Sciences of the United States of America. 81: 3163-3166. PMID 6328503 DOI: 10.1073/Pnas.81.10.3163  0.375
1984 Nebert DW, Eisen HJ, Hankinson O. The Ah receptor: binding specificity only for foreign chemicals? Biochemical Pharmacology. 33: 917-24. PMID 6324804 DOI: 10.1016/0006-2952(84)90446-5  0.39
1984 Kimura S, Gonzalez FJ, Nebert DW. Mouse cytochrome P3-450: Complete cDNA and amino acid sequence Nucleic Acids Research. 12: 2917-2928. PMID 6324134 DOI: 10.1093/Nar/12.6.2917  0.326
1984 Legraverend C, Guenthner TM, Nebert DW. Importance of the route of administration for genetic differences in benzo[a]pyrene-induced in utero toxicity and teratogenicity. Teratology. 29: 35-47. PMID 6322374 DOI: 10.1002/Tera.1420290106  0.393
1984 Kouri RE, McKinney CE, Levine AS, Edwards BK, Vesell ES, Nebert DW, McLemore TL. Variations in aryl hydrocarbon hydroxylase activities in mitogen-activated human and nonhuman primate lymphocytes. Toxicologic Pathology. 12: 44-8. PMID 6093229 DOI: 10.1177/019262338401200107  0.356
1983 Nakamura M, Negishi M, Altieri M, Chen YT, Ikeda T, Tukey RH, Nebert DW. Structure of the mouse cytochrome P1-450 genomic gene European Journal of Biochemistry. 134: 19-25. PMID 6861759 DOI: 10.1111/J.1432-1033.1983.Tb07525.X  0.343
1983 Ikeda T, Altieri M, Chen YT, Nakamura M, Tukey RH, Nebert DW, Negishi M. Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole. European Journal of Biochemistry. 134: 13-8. PMID 6861755 DOI: 10.1111/J.1432-1033.1983.Tb07524.X  0.344
1983 Kour RE, Connolly GM, Nebert DW, Lubet RA. Association between susceptibility to dibenzanthracene-induced fibrosarcoma formation and the Ah locus International Journal of Cancer. 32: 765-768. PMID 6654528 DOI: 10.1002/Ijc.2910320618  0.349
1983 Chen YT, Bigelow SW, Levitt RC, Nebert DW. Screening of 16 common therapeutic drugs. Possible association with the Ah locus. Developmental Pharmacology and Therapeutics. 6: 269-83. PMID 6617407 DOI: 10.1159/000457313  0.355
1983 Lubet RA, Connolly G, Kouri RE, Nebert DW, Bigelow SW. Biological effects of the Sudan dyes. Role of the Ah cytosolic receptor. Biochemical Pharmacology. 32: 3053-8. PMID 6315015 DOI: 10.1016/0006-2952(83)90248-4  0.338
1983 Legraverend C, Harrison DE, Ruscetti FW, Nebert DW. Bone marrow toxicity induced by oral benzo[a]pyrene: protection resides at the level of the intestine and liver. Toxicology and Applied Pharmacology. 70: 390-401. PMID 6314600 DOI: 10.1016/0041-008X(83)90157-6  0.375
1983 Eisen HJ, Hannah RR, Legraverend C, Okey AB, Nebert DW. CHAPTER 7 – The Ah Receptor: Controlling Factor in the Induction of Drug-Metabolizing Enzymes by Certain Chemical Carcinogens and Other Environmental Pollutants Biochemical Actions of Hormones. 227-257. DOI: 10.1016/B978-0-12-452810-9.50012-7  0.313
1982 Chen YT, Lang MA, Jensen NM, Negishi M, Tukey RH, Sidransky E, Guenther TM, Nebert DW. Similarities between mouse and rat-liver microsomal cytochromes P-450 induced by 3-methylcholanthrene. Evidence from catalytic, immunologic, and recombinant DNA studies European Journal of Biochemistry. 122: 361-368. PMID 7082463 DOI: 10.1111/J.1432-1033.1982.Tb05889.X  0.353
1982 Bigelow SW, Nebert DW. The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[a]pyrene metabolites' capacity to bind to the cytosolic receptor. Toxicology Letters. 10: 109-18. PMID 7080063 DOI: 10.1016/0378-4274(82)90276-4  0.341
1982 Shichi H, Nebert DW. Genetic differences in drug metabolism associated with ocular toxicity. Environmental Health Perspectives. 44: 107-17. PMID 7044772 DOI: 10.1289/Ehp.8244107  0.336
1982 Nebert DW, Negishi M, Lang MA, Hjelmeland LM, Eisen HJ. The Ah locus, a multigene family necessary for survival in a chemically adverse environment: comparison with the immune system. Advances in Genetics. 21: 1-52. PMID 7036691 DOI: 10.1016/S0065-2660(08)60296-5  0.377
1982 Tukey RH, Hannah RR, Negishi M, Nebert DW, Eisen HJ. The Ah locus: Correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA Cell. 31: 275-284. PMID 6186383 DOI: 10.1016/0092-8674(82)90427-5  0.368
1981 Pelkonen O, Vähäkangas K, Nebert DW. Binding of polycyclic aromatic hydrocarbons to DNA: comparison with mutagenesis and tumorigenesis. Journal of Toxicology and Environmental Health. 6: 1009-20. PMID 7463499 DOI: 10.1080/15287398009529923  0.302
1981 Nebert DW. Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia. Environmental Health Perspectives. 39: 11-22. PMID 7016519 DOI: 10.1289/Ehp.813911  0.371
1981 Negishi M, Swan DC, Enquist LW, Nebert DW. Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proceedings of the National Academy of Sciences of the United States of America. 78: 800-4. PMID 6262772 DOI: 10.1073/Pnas.78.2.800  0.337
1980 Kano I, Nebert DW. Subcellular localization of membrane-bound aryl-hydrocarbon hydroxylase and NAD(P)H-dependent reductase activities in mouse liver. European Journal of Biochemistry. 109: 25-31. PMID 7408879 DOI: 10.1111/J.1432-1033.1980.Tb04763.X  0.375
1980 Shichi H, Tanaka M, Jensen NM, Nebert DW. Genetic differences in cataract and other ocular abnormalities induced by paracetamol and naphthalene Pharmacology. 20: 229-241. PMID 7393992 DOI: 10.1159/000137369  0.31
1980 Legraverend C, Nebert DW, Boobis AR, Pelkonen O. DNA binding of benzo[a]pyrene metabolites. Effects of substrate and microsomal protein concentration in vitro, dietary contaminants, and tissue differences. Pharmacology. 20: 137-48. PMID 7384194 DOI: 10.1159/000137357  0.409
1980 Galloway SM, Perry PE, Meneses J, Nebert DW, Pedersen RA. Cultured mouse embryos metabolize benzo[a]pyrene during early gestation: genetic differences detectable by sister chromatid exchange. Proceedings of the National Academy of Sciences of the United States of America. 77: 3524-8. PMID 6932035 DOI: 10.1073/Pnas.77.6.3524  0.399
1980 Guenthner TM, Kahl GF, Nebert DW. NADPH-cytochrome P-450 reductase: preferential inhibition by ellipticine and other type II compounds having little effect on NADPH-cytochrome c reductase. Biochemical Pharmacology. 29: 89-95. PMID 6767479 DOI: 10.1016/0006-2952(80)90249-X  0.314
1980 Guenthner TM, Fysh JM, Nebert DW. 2,3,7,8-Tetrachlorodibenzo-p-dioxin: covalent binding of reactive metabolic intermediates principally to protein in vitro. Pharmacology. 19: 12-22. PMID 515166 DOI: 10.1159/000137278  0.347
1980 Nebert DW, Bigelow SW, Okey AB, Yahagi T, Mori Y, Nagao M, Sugimura T. Pyrolysis products from amino acids and protein: highest mutagenicity requires cytochrome P1-450. Proceedings of the National Academy of Sciences of the United States of America. 76: 5929-33. PMID 293693 DOI: 10.1073/Pnas.76.11.5929  0.341
1980 Nebert DW. Multiple forms of inducible drug-metabolizing enzymes: a reasonable mechanism by which any organism can cope with adversity. Molecular and Cellular Biochemistry. 27: 27-46. PMID 229404 DOI: 10.1007/Bf00849277  0.388
1980 Atlas SA, Zweier JL, Nebert DW. Genetic Differences in Phenytoin Pharmacokinetics In vivo Clearance andin vitro Metabolism among Inbred Strains of Mice Developmental Pharmacology and Therapeutics. 1: 281-304. DOI: 10.1159/000455547  0.364
1980 Kahl GF, Friederici DE, Bigelow SW, Okey AB, Nebert DW. Ontogenetic Expression of Regulatory and Structural Gene Products Associated with the Ah Locus Developmental Pharmacology and Therapeutics. 1: 137-162. DOI: 10.1159/000455531  0.414
1980 Negishi M, Nebert DW. STRUCTURAL GENE PRODUCTS OF THE MURINE Ah LOCUS. IMMUNOCHEMICAL CHARACTERIZATION OF TWO FORMS OF P-450 INDUCED BY POLYCYCLIC AROMATIC COMPOUNDS Microsomes, Drug Oxidations and Chemical Carcinogenesis. 155-158. DOI: 10.1016/B978-0-12-187701-9.50029-2  0.395
1979 Nebert DW, Jensen NM. Benzo[a]pyrene-initiated leukemia in mice. Association with allelic differences at the Ah locus Biochemical Pharmacology. 28: 149-151. PMID 758905 DOI: 10.1016/0006-2952(79)90284-3  0.322
1979 Guenthner TM, Nebert DW. Evidence in rat and mouse liver for temporal control of two forms of cytochrome P-450 inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin. European Journal of Biochemistry. 91: 449-56. PMID 729578 DOI: 10.1111/J.1432-1033.1978.Tb12697.X  0.355
1979 Shum S, Jensen NM, Nebert DW. The murine Ah locus: In utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism Teratology. 20: 365-376. PMID 542892 DOI: 10.1002/Tera.1420200307  0.313
1979 Guenthner TM, Negishi M, Nebert DW. Separation of acetanilide and its hydroxylated metabolites and quantitative determination of "acetanilide 4-hydroxylase activity" by high-pressure liquid chromatography Analytical Biochemistry. 96: 201-207. PMID 495983 DOI: 10.1016/0003-2697(79)90573-6  0.355
1979 Pelkonen O, Boobis AR, Levitt RC, Kouri RE, Nebert DW. Genetic differences in the metabolic activation of benzo[a]pyrene in mice. Attempts to correlate tumorigenesis with binding of reactive intermediates to DNA and with mutagenesis in vitro. Pharmacology. 18: 281-93. PMID 493333 DOI: 10.1159/000137267  0.337
1979 Kahl GF, Klaus E, Legraverend C, Nebert DW, Pelkonen O. Formation of benzo[a]pyrene metabolite-nucleoside adducts in isolated perfused rat and mouse liver and in mouse lung slices. Biochemical Pharmacology. 28: 1051-6. PMID 444261 DOI: 10.1016/0006-2952(79)90302-2  0.329
1979 Boobis AR, Nebert DW, Pelkonen O. Effects of microsomal enzyme inducers in vivo and inhibitors in vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonresponsive mice. Biochemical Pharmacology. 28: 111-21. PMID 103557 DOI: 10.1016/0006-2952(79)90278-8  0.39
1979 Levitt RC, Pelkonen O, Okey AB, Nebert DW. Genetic Differences in Metabolism of Polycyclic Aromatic Carcinogens and Aromatic Amines by Mouse Liver Microsomes. Detection by DNA Binding of Metabolites and by Mutagenicity in Histidine-Dependent Salmonella typhimurium In Vitro Journal of the National Cancer Institute. 62: 947-955. DOI: 10.1093/Jnci/62.4.947  0.382
1978 Boobis AR, Atlas SA, Nebert DW. Carcinogenic benzo(a)pyrene metabolites bound to DNA: metabolic formation by human cultured lymphocytes and by human liver microsomes. Pharmacology. 17: 241-8. PMID 704661 DOI: 10.1159/000136862  0.327
1978 Owens IS, Nebert DW, Liem HH, Müller-Eberhard U. Hemopexin and aryl hydrocarbon hydroxylase induction in the mouse and in cell culture. Biochemical Pharmacology. 27: 1665-9. PMID 697907 DOI: 10.1016/0006-2952(78)90176-4  0.325
1978 Nebert DW. Genetic differences in microsomal electron transport: the Ah locus. Methods in Enzymology. 52: 226-40. PMID 672631 DOI: 10.1016/S0076-6879(78)52026-0  0.322
1978 Shichi H, Gaasterland DE, Jensen NM, Nebert DW. Ah locus: Genetic differences in susceptibility to cataracts induced by acetaminophen Science. 200: 539-541. PMID 644313 DOI: 10.1126/Science.644313  0.315
1978 Levitt RC, Legraverend C, Nebert DW, Pelkonen O. Effects of harman and norharman on the mutagenicity and binding to DNA of benzo[a]pyrene metabolites in vitro and on aryl hydrocarbon hydroxylase induction in cell culture. Biochemical and Biophysical Research Communications. 79: 1167-75. PMID 603652 DOI: 10.1016/0006-291X(77)91129-9  0.352
1978 Lambert GH, Nebert DW. Genetically mediated induction of drug-metabolizing enzymes associated with congenital defects in the mouse. Teratology. 16: 147-53. PMID 412268 DOI: 10.1002/Tera.1420160206  0.376
1978 Shichi H, Kumaki K, Nebert DW. Circular dichroism studies on the binding of type I substrates and reverse type I compounds to rabbit liver microsomal cytochrome P-450. Chemico-Biological Interactions. 20: 133-48. PMID 25718 DOI: 10.1016/0009-2797(78)90048-0  0.301
1978 Atlas SA, Nebert DW. Pharmacogenetics: a possible pragmatic perspective in neoplasm predictability. Seminars in Oncology. 5: 89-106. DOI: 10.5555/Uri:Pii:0093775478900246  0.37
1978 Nebert DW, Atlas SA, Guenthner TM, Kouri RE. 21 – The Ah Locus: Genetic Regulation of the Enzymes which Metabolize Polycyclic Hydrocarbons and the Risk for Cancer Molecular and Cellular Biology. 345-390. DOI: 10.1016/B978-0-12-279202-1.50028-2  0.311
1977 Boobis AR, Nebert DW. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. Advances in Enzyme Regulation. 15: 339-62. PMID 1030186 DOI: 10.1016/0065-2571(77)90024-3  0.424
1977 Nebert DW, Thorgeirsson SS, Lambert GH. Genetic aspects of toxicity during development. Environmental Health Perspectives. 18: 35-45. PMID 829488 DOI: 10.1289/Ehp.761835  0.429
1977 Nebert DW, Levitt RC, Jensen NM, Lambert GH, Felton JS. Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus Archives of Toxicology. 39: 109-132. PMID 414694 DOI: 10.1007/Bf00343280  0.41
1977 Thorgeirsson SS, Nebert DW. The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. Advances in Cancer Research. 25: 149-93. PMID 405846 DOI: 10.1016/S0065-230X(08)60634-X  0.403
1977 Shum S, Lambert GH, Nebert DW, Schulman J. THE MURINE Ah LOCUS AND DYSMORPHOGENESIS Pediatric Research. 11: 529-529. DOI: 10.1203/00006450-197704000-00957  0.399
1976 Shichi H, Atlas SA, Nebert DW. Genetically regulated aryl hydrocarbon hydroxylase induction in the eye: possible significance of the drug-metabolizing enzyme system for the retinal pigmented epithelium-choroid. Experimental Eye Research. 21: 557-67. PMID 1204684 DOI: 10.1016/0014-4835(75)90038-X  0.349
1976 Shichi H, Tsunematsu Y, Nebert DW. Aryl hydrocarbon hydroxylase induction in retinal pigmented epithelium: possible association of genetic differences in a drug-metabolizing enzyme system with retinal degeneration. Experimental Eye Research. 23: 165-76. PMID 976366 DOI: 10.1016/0014-4835(76)90200-1  0.323
1976 Atlas SA, Nebert DW. Genetic association of increases in naphthalene, acetanilide, and biphenyl hydroxylations with inducible aryl hydrocarbon hydroxylase in mice. Archives of Biochemistry and Biophysics. 175: 495-506. PMID 958314 DOI: 10.1016/0003-9861(76)90537-3  0.389
1976 Owens IS, Nebert DW. Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Effects of various metabolic inhibitors on the enzyme activity in hepatoma cells. Biochemical Pharmacology. 25: 805-13. PMID 181006 DOI: 10.1016/0006-2952(76)90151-9  0.339
1975 Atlas AS, Thorgeirsson SS, Boobis AR, Kumaki K, Nebert DW. Differential induction of murine Ah locus-associated monooxygenase activities in rabbit liver and kidney. Biochemical Pharmacology. 24: 2111-6. PMID 1212260 DOI: 10.1016/0006-2952(75)90114-8  0.303
1975 Niwa A, Kumaki K, Nebert DW, Poland AP. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the "responsive" homozygote and heterozygote at the Ah locus. Archives of Biochemistry and Biophysics. 166: 559-64. PMID 1119809 DOI: 10.1016/0003-9861(75)90420-8  0.332
1975 Nebert DW, Felton JS. Evidence for the activation of 3-methylcholanthrene as a carcinogen in vivo and asa mutagen in vitro by P1 -450 from inbred strains of mice. Advances in Experimental Medicine and Biology. 58: 127-49. PMID 1098415 DOI: 10.1007/978-1-4615-9026-2_9  0.392
1975 Nebert DW, Robinson JR, Niwa A, Kumaki K, Poland AP. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Journal of Cellular Physiology. 85: 393-414. PMID 1091656 DOI: 10.1002/Jcp.1040850407  0.416
1973 Nebert DW, Considine N, Owens IS. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. Archives of Biochemistry and Biophysics. 157: 148-59. PMID 4716952 DOI: 10.1016/0003-9861(73)90400-1  0.391
1973 Benedict WF, Gielen JE, Owens IS, Niwa A, Nebert DW. Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver. Biochemical Pharmacology. 22: 2766-2769. PMID 4357894 DOI: 10.1016/0006-2952(73)90138-X  0.305
1972 Benedict WF, Paul B, Nebert DW. Expression of benz[a]anthracene-inducible aryl hydrocarbon hydroxylase activity in mouse-hamster and mouse-human somatic-cell hybrids. Biochemical and Biophysical Research Communications. 48: 293-8. PMID 5065063 DOI: 10.1016/S0006-291X(72)80049-4  0.372
1972 Nebert DW, Goujon FM, Gielen JE. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nature: New Biology. 236: 107-10. PMID 4502804 DOI: 10.1038/Newbio236107A0  0.334
1972 Benedict WF, Nebert DW, Thompson EB. Expression of aryl hydrocarbon hydroxylase induction and suppression of tyrosine aminotransferase induction in somatic-cell hybrids Proceedings of the National Academy of Sciences of the United States of America. 69: 2179-2183. PMID 4403306 DOI: 10.1073/Pnas.69.8.2179  0.307
1971 Gielen JE, Nebert DW. Microsomal hydroxylase induction in liver cell culture by phenobarbital, polycyclic hydrocarbons, and p,p'-DDT. Science (New York, N.Y.). 172: 167-9. PMID 5547730 DOI: 10.1126/Science.172.3979.167  0.307
1969 Nebert DW. Changes in aryl hydrocarbon hydroxylase activity and microsomal P450 during polycyclic hydrocarbon treatment of mammalian cells in culture. Biochemical and Biophysical Research Communications. 36: 885-90. PMID 5344723 DOI: 10.1016/0006-291X(69)90286-1  0.327
1969 Nebert DW, Gelboin HV. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. Archives of Biochemistry and Biophysics. 134: 76-89. PMID 4981257 DOI: 10.1016/0003-9861(69)90253-7  0.345
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