| Year |
Citation |
Score |
| 2021 |
Connolly NP, Galisteo R, Xu S, Bar EE, Peng S, Tran NL, Ames HM, Kim AJ, Woodworth GF, Winkles JA. Elevated fibroblast growth factor-inducible 14 expression transforms proneural-like gliomas into more aggressive and lethal brain cancer. Glia. PMID 33991013 DOI: 10.1002/glia.24018 |
0.333 |
|
| 2020 |
Alvarez de Cienfuegos A, Cheung LH, Mohamedali KA, Whitsett TG, Winkles JA, Hittlerman WN, Rosenblum MG. Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B. Journal For Immunotherapy of Cancer. 8. PMID 32958685 DOI: 10.1136/Jitc-2020-001138 |
0.321 |
|
| 2020 |
Dancy JG, Wadajkar AS, Connolly NP, Galisteo R, Ames HM, Peng S, Tran NL, Goloubeva OG, Woodworth GF, Winkles JA, Kim AJ. Decreased nonspecific adhesivity, receptor-targeted therapeutic nanoparticles for primary and metastatic breast cancer. Science Advances. 6: eaax3931. PMID 31998833 DOI: 10.1126/Sciadv.Aax3931 |
0.324 |
|
| 2018 |
Roberts NB, Alqazzaz A, Hwang JR, Qi X, Keegan AD, Kim AJ, Winkles JA, Woodworth GF. Oxaliplatin disrupts pathological features of glioma cells and associated macrophages independent of apoptosis induction. Journal of Neuro-Oncology. PMID 30132163 DOI: 10.1007/S11060-018-2979-1 |
0.321 |
|
| 2018 |
Hersh DS, Harder BG, Roos A, Peng S, Heath JE, Legesse T, Kim AJ, Woodworth GF, Tran NL, Winkles JA. The TNF Receptor Family Member Fn14 is Highly Expressed in Recurrent Glioblastoma (GBM) and in GBM Patient-Derived Xenografts With Acquired Temozolomide Resistance. Neuro-Oncology. PMID 29897522 DOI: 10.1093/Neuonc/Noy063 |
0.334 |
|
| 2018 |
Roos A, Dhruv HD, Peng S, Inge LJ, Tuncali S, Pineda M, Millard N, Mayo Z, Eschbacher JM, Loftus JC, Winkles JA, Tran NL. EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival. Molecular Cancer Research : McR. PMID 29724813 DOI: 10.1158/1541-7786.Mcr-18-0125 |
0.442 |
|
| 2018 |
Hersh DS, Peng S, Dancy JG, Galisteo R, Eschbacher JM, Castellani RJ, Heath JE, Legesse T, Kim AJ, Woodworth GF, Tran NL, Winkles JA. Differential expression of the TWEAK receptor Fn14 in IDH1 wild-type and mutant gliomas. Journal of Neuro-Oncology. PMID 29453678 DOI: 10.1007/S11060-018-2799-3 |
0.479 |
|
| 2018 |
Connolly NP, Shetty AC, Stokum JA, Hoeschele I, Siegel MB, Miller CR, Kim AJ, Ho CY, Davila E, Simard JM, Devine SE, Rossmeisl JH, Holland EC, Winkles JA, Woodworth GF. Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma. Scientific Reports. 8: 1180. PMID 29352201 DOI: 10.1038/S41598-018-19451-6 |
0.365 |
|
| 2018 |
Harder B, Sereduk C, Dhruv H, Millard N, Kim A, Winkles J, Woodworth G, Yin H, Tran NL. Abstract 4910: Development of an antagonist to the TWEAK-Fn14 ligand-receptor interaction with enhanced efficacy/potency in glioblastoma cells Cancer Research. 78: 4910-4910. DOI: 10.1158/1538-7445.Am2018-4910 |
0.386 |
|
| 2017 |
Wadajkar AS, Dancy JG, Roberts NB, Connolly NP, Strickland DK, Winkles JA, Woodworth GF, Kim AJ. Decreased non-specific adhesivity, receptor targeted (DART) nanoparticles exhibit improved dispersion, cellular uptake, and tumor retention in invasive gliomas. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 28887134 DOI: 10.1016/J.Jconrel.2017.09.006 |
0.32 |
|
| 2017 |
Connolly NP, Stokum JA, Schneider CS, Ozawa T, Xu S, Galisteo R, Castellani RJ, Kim AJ, Simard JM, Winkles JA, Holland EC, Woodworth GF. Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer. Plos One. 12: e0174557. PMID 28358926 DOI: 10.1371/Journal.Pone.0174557 |
0.334 |
|
| 2017 |
Roos A, Dhruv HD, Mathews IT, Inge LJ, Tuncali S, Hartman LK, Chow D, Millard N, Yin HH, Kloss J, Loftus JC, Winkles JA, Berens ME, Tran NL. Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells. Oncotarget. PMID 28103571 DOI: 10.18632/Oncotarget.14685 |
0.446 |
|
| 2017 |
Connolly NP, Schneider CS, Shetty A, Xu S, Ozawa T, Kim AJ, Winkles JA, Holland E, Woodworth GF. Abstract 808: PDGF-A overexpression and p53 depletion in rat neural precursor cells induces large brain tumors that resemble human glioblastoma Cancer Research. 77: 808-808. DOI: 10.1158/1538-7445.Am2017-808 |
0.33 |
|
| 2017 |
Cienfuegos AAd, Cheung LH, Mohamedali KAA, Winkles JA, Rosenblum MG. Abstract 4587: A human hybrid immuno-oncology construct targeting the TWEAK receptor Fn14 and containing the serine protease granzyme B Cancer Research. 77: 4587-4587. DOI: 10.1158/1538-7445.Am2017-4587 |
0.405 |
|
| 2017 |
Wadajkar AS, Dancy JG, Connolly NP, Winkles JA, Woodworth GF, Kim AJ. Abstract 3107: Targeting nanotherapeutics to the invasive glioblastoma margin via the cell surface receptor Fn14 Cancer Research. 77: 3107-3107. DOI: 10.1158/1538-7445.Am2017-3107 |
0.343 |
|
| 2017 |
Alison R, Sabir M, Sereduk C, Tuncali S, Pineda M, Millard N, Dhruv HD, Peng S, Berens ME, Loftus JC, Winkles JA, Tran NL. P08.02 EGFRvIII induced GBM invasion and survival is dependent upon Stat5 activation and Fn14 expression Neuro-Oncology. 19: iii53-iii54. DOI: 10.1093/Neuonc/Nox036.192 |
0.336 |
|
| 2016 |
Armstrong CL, Galisteo R, Brown SA, Winkles JA. TWEAK activation of the non-canonical NF-κB signaling pathway differentially regulates melanoma and prostate cancer cell invasion. Oncotarget. PMID 27821799 DOI: 10.18632/Oncotarget.13034 |
0.402 |
|
| 2016 |
Wadajkar AS, Dancy JG, Hersh DS, Anastasiadis P, Tran NL, Woodworth GF, Winkles JA, Kim AJ. Tumor-targeted nanotherapeutics: overcoming treatment barriers for glioblastoma. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. PMID 27813323 DOI: 10.1002/Wnan.1439 |
0.382 |
|
| 2016 |
Roos A, Mayo Z, Sonnemann H, Pineda M, Lambert G, Dhruv HD, Winkles JA, Berens ME, Tran NL. Abstract 700: Regulation of Fn14 expression by EGFRvIII-STAT signaling enhances glioblastoma cell invasion and survival Cancer Research. 76: 700-700. DOI: 10.1158/1538-7445.Am2016-700 |
0.471 |
|
| 2016 |
Alvarez-Cienfuegos A, Cheung LH, Mohamedali KA, Zhao Y, Ruisaard KE, Winkles JA, Rosenblum MG. Abstract 575: Human serine protease therapeutics- potent constructs targeting Fn14 in multiple tumor types Cancer Research. 76: 575-575. DOI: 10.1158/1538-7445.Am2016-575 |
0.4 |
|
| 2016 |
Roos A, Mayo Z, Sonnemann H, Lambert G, Dhruv H, Winkles J, Berens M, Tran N, Sabir M. CSIG-24. REGULATION OF Fn14 EXPRESSION BY EGFRvIII-STAT SIGNALING ENHANCES GLIOBLASTOMA CELL INVASION AND SURVIVAL Neuro-Oncology. 18: vi45-vi46. DOI: 10.1093/Neuonc/Now212.185 |
0.387 |
|
| 2015 |
Perez JG, Tran NL, Rosenblum MG, Schneider CS, Connolly NP, Kim AJ, Woodworth GF, Winkles JA. The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics. Oncogene. PMID 26300004 DOI: 10.1038/Onc.2015.310 |
0.434 |
|
| 2015 |
Schneider CS, Perez JG, Cheng E, Zhang C, Mastorakos P, Hanes J, Winkles JA, Woodworth GF, Kim AJ. Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells. Biomaterials. 42: 42-51. PMID 25542792 DOI: 10.1016/J.Biomaterials.2014.11.054 |
0.305 |
|
| 2015 |
Cheng E, Whitsett TG, Tran NL, Winkles JA. The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion. Molecular Cancer Research : McR. 13: 575-83. PMID 25392346 DOI: 10.1158/1541-7786.Mcr-14-0411 |
0.366 |
|
| 2015 |
Roos A, Mayo Z, Pineda M, Winkles JA, Berens ME, Tran NL. CSIG-13INVESTIGATING THE ROLE OF Fn14 IN EGFRvIII-DRIVEN GLIOBLASTOMA Neuro-Oncology. 17: v68.3-v68. DOI: 10.1093/Neuonc/Nov210.13 |
0.463 |
|
| 2014 |
Zhou H, Mohamedali KA, Gonzalez-Angulo AM, Cao Y, Migliorini M, Cheung LH, LoBello J, Lei X, Qi Y, Hittelman WN, Winkles JA, Tran NL, Rosenblum MG. Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC. Molecular Cancer Therapeutics. 13: 2688-705. PMID 25239934 DOI: 10.1158/1535-7163.Mct-14-0346 |
0.402 |
|
| 2014 |
Gurunathan S, Winkles JA, Ghosh S, Hayden MS. Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. The Journal of Biological Chemistry. 289: 12976-88. PMID 24652288 DOI: 10.1074/Jbc.M114.563478 |
0.51 |
|
| 2014 |
Dhruv HD, Whitsett TG, Jameson NM, Patel F, Winkles JA, Berens ME, Tran NL. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation. Carcinogenesis. 35: 218-26. PMID 23975833 DOI: 10.1093/Carcin/Bgt289 |
0.458 |
|
| 2014 |
Zhou H, Mohamedali KA, Cao Y, Migliorini M, Cheung LH, Hittelman WN, Winkles JA, Rosenblum MG. Abstract 4512: Construction and characterization of novel, human serine protease granzyme B-based cancer therapeutics targeting the TNFR family member Fn14 Cancer Research. 74: 4512-4512. DOI: 10.1158/1538-7445.Am2014-4512 |
0.437 |
|
| 2013 |
Cheng E, Armstrong CL, Galisteo R, Winkles JA. TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic. Frontiers in Immunology. 4: 473. PMID 24391646 DOI: 10.3389/Fimmu.2013.00473 |
0.411 |
|
| 2013 |
Brown SA, Cheng E, Williams MS, Winkles JA. TWEAK-independent Fn14 self-association and NF-κB activation is mediated by the C-terminal region of the Fn14 cytoplasmic domain. Plos One. 8: e65248. PMID 23750247 DOI: 10.1371/Journal.Pone.0065248 |
0.434 |
|
| 2013 |
Zhou H, Hittelman WN, Yagita H, Cheung LH, Martin SS, Winkles JA, Rosenblum MG. Antitumor activity of a humanized, bivalent immunotoxin targeting fn14-positive solid tumors. Cancer Research. 73: 4439-50. PMID 23722548 DOI: 10.1158/0008-5472.Can-13-0187 |
0.428 |
|
| 2013 |
Asrani K, Keri RA, Galisteo R, Brown SA, Morgan SJ, Ghosh A, Tran NL, Winkles JA. The HER2- and heregulin β1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression. Molecular Cancer Research : McR. 11: 393-404. PMID 23378579 DOI: 10.1158/1541-7786.Mcr-12-0542 |
0.44 |
|
| 2013 |
Zhou H, Ekmekcioglu S, Marks JW, Mohamedali KA, Asrani K, Phillips KK, Brown SA, Cheng E, Weiss MB, Hittelman WN, Tran NL, Yagita H, Winkles JA, Rosenblum MG. The TWEAK receptor Fn14 is a therapeutic target in melanoma: immunotoxins targeting Fn14 receptor for malignant melanoma treatment. The Journal of Investigative Dermatology. 133: 1052-62. PMID 23190886 DOI: 10.1038/Jid.2012.402 |
0.458 |
|
| 2013 |
Zhou H, Migliorini M, Cao Y, Cheung LH, Hittelman WN, Winkles JA, Rosenblum MG. Abstract 2185: Development and characterization of the fully human chimeric protein GrB-TWEAK targeting Fn14-positive solid tumor cells. Cancer Research. 73: 2185-2185. DOI: 10.1158/1538-7445.Am2013-2185 |
0.449 |
|
| 2013 |
Zhou H, Migliorini M, Hittelman W, Ekmekcioglu S, Tran N, LoBello J, Winkles JA, Rosenblum MG. Abstract C231: Novel, fully-human GrB-containing constructs targeting the Fn14 receptor for TWEAK on solid tumor cells. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C231 |
0.46 |
|
| 2012 |
Whitsett TG, Cheng E, Inge L, Asrani K, Jameson NM, Hostetter G, Weiss GJ, Kingsley CB, Loftus JC, Bremner R, Tran NL, Winkles JA. Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion. The American Journal of Pathology. 181: 111-20. PMID 22634180 DOI: 10.1016/J.Ajpath.2012.03.026 |
0.411 |
|
| 2012 |
Fortin SP, Ennis MJ, Schumacher CA, Zylstra-Diegel CR, Williams BO, Ross JT, Winkles JA, Loftus JC, Symons MH, Tran NL. Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells. Molecular Cancer Research : McR. 10: 958-68. PMID 22571869 DOI: 10.1158/1541-7786.Mcr-11-0616 |
0.436 |
|
| 2012 |
Zhou H, Ekmekcioglu S, Marks JW, Asrani K, Phillips KK, Brown S, Cheng E, Weiss MB, Hittelman WN, Tran NL, Yagita H, Winkles JA, Rosenblum MG. Abstract 3866: TWEAK receptor (Fn14) Is a novel target in melanoma: Characterization of unique targeted therapeutics Cancer Research. 72: 3866-3866. DOI: 10.1158/1538-7445.Am2012-3866 |
0.452 |
|
| 2012 |
Dhruv HD, Jameson N, Patel F, Nakada M, Armstrong B, Winkles JA, Berens ME, Tran NL. Abstract 306: TWEAK functions as chemotactic factor for glioma cells via Lyn activation Cancer Research. 72: 306-306. DOI: 10.1158/1538-7445.Am2012-306 |
0.477 |
|
| 2011 |
Ranganathan S, Noyes NC, Migliorini M, Winkles JA, Battey FD, Hyman BT, Smith E, Yepes M, Mikhailenko I, Strickland DK. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10836-46. PMID 21795536 DOI: 10.1523/Jneurosci.5065-10.2011 |
0.37 |
|
| 2011 |
Zhou H, Marks JW, Hittelman WN, Yagita H, Cheung LH, Rosenblum MG, Winkles JA. Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells. Molecular Cancer Therapeutics. 10: 1276-88. PMID 21586630 DOI: 10.1158/1535-7163.Mct-11-0161 |
0.499 |
|
| 2011 |
Zhou H, Marks JW, Ekmekcioglu S, Hittelman WN, Tran N, Yagita H, Winkles JA, Rosenblum MG. Abstract 1766: Development of single chain immunotoxins targeting the fibroblast growth factor-inducible 14 (Fn14) receptor on solid tumor cells Cancer Research. 71: 1766-1766. DOI: 10.1158/1538-7445.Am2011-1766 |
0.447 |
|
| 2011 |
Tran NL, Asrani K, Jameson N, Inge L, Cheng E, Hostetter G, Weiss G, Tuncali S, Bremner R, Winkles JA. Abstract 1216: The Fn14 receptor is highly expressed in NSCLC tumors and in NSCLC cell lines harboring EGFR-activating mutations Cancer Research. 71: 1216-1216. DOI: 10.1158/1538-7445.Am2011-1216 |
0.419 |
|
| 2010 |
Brown SA, Ghosh A, Winkles JA. Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. The Journal of Biological Chemistry. 285: 17432-41. PMID 20385556 DOI: 10.1074/Jbc.M110.131979 |
0.42 |
|
| 2010 |
Kim HJ, Minashima T, McCarthy EF, Winkles JA, Kirsch T. Progressive ankylosis protein (ANK) in osteoblasts and osteoclasts controls bone formation and bone remodeling. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 25: 1771-83. PMID 20200976 DOI: 10.1002/Jbmr.60 |
0.366 |
|
| 2010 |
Ennis MJ, McDonough WS, Chan A, Symons MH, Winkles JA, Salhia B, Loftus JC, Tran NL. Abstract 5128: Identification of RhoGEFs within the TWEAK-R (Fn14)-Rac1 signaling pathway that mediate glioblastoma cell invasion Cancer Research. 70: 5128-5128. DOI: 10.1158/1538-7445.Am10-5128 |
0.423 |
|
| 2010 |
Asrani KV, Winkles JA. Abstract 3169: HER2 signaling regulates Fn14 receptor expression in breast cancer cells Cancer Research. 70: 3169-3169. DOI: 10.1158/1538-7445.Am10-3169 |
0.448 |
|
| 2010 |
Zhou H, Marks JW, Winkles JA, Yagita H, Rosenblum MG. Abstract 2574: Development and characterization of a potent immunotoxin targeting the Fn14 receptor on solid tumor cells Cancer Research. 70: 2574-2574. DOI: 10.1158/1538-7445.Am10-2574 |
0.431 |
|
| 2009 |
Fortin SP, Ennis MJ, Savitch BA, Carpentieri D, McDonough WS, Winkles JA, Loftus JC, Kingsley C, Hostetter G, Tran NL. Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function. Molecular Cancer Research : McR. 7: 1871-81. PMID 19861406 DOI: 10.1158/1541-7786.Mcr-09-0194 |
0.455 |
|
| 2009 |
Kirsch T, Kim HJ, Winkles JA. Progressive ankylosis gene (ank) regulates osteoblast differentiation. Cells, Tissues, Organs. 189: 158-62. PMID 18728347 DOI: 10.1159/000151725 |
0.379 |
|
| 2008 |
Yang Y, Bai J, Shen R, Brown SA, Komissarova E, Huang Y, Jiang N, Alberts GF, Costa M, Lu L, Winkles JA, Dai W. Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions. Cancer Research. 68: 4077-85. PMID 18519666 DOI: 10.1158/0008-5472.Can-07-6182 |
0.75 |
|
| 2008 |
Willis AL, Tran NL, Chatigny JM, Charlton N, Vu H, Brown SA, Black MA, McDonough WS, Fortin SP, Niska JR, Winkles JA, Cunliffe HE. The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity. Molecular Cancer Research : McR. 6: 725-34. PMID 18505918 DOI: 10.1158/1541-7786.Mcr-08-0005 |
0.436 |
|
| 2008 |
Winkles JA. The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting. Nature Reviews. Drug Discovery. 7: 411-25. PMID 18404150 DOI: 10.1038/Nrd2488 |
0.365 |
|
| 2008 |
Sanz AB, Justo P, Sanchez-Niño MD, Blanco-Colio LM, Winkles JA, Kreztler M, Jakubowski A, Blanco J, Egido J, Ruiz-Ortega M, Ortiz A. The cytokine TWEAK modulates renal tubulointerstitial inflammation. Journal of the American Society of Nephrology : Jasn. 19: 695-703. PMID 18235096 DOI: 10.1681/ASN.2007050577 |
0.311 |
|
| 2007 |
Winkles JA, Tran NL, Brown SA, Stains N, Cunliffe HE, Berens ME. Role of TWEAK and Fn14 in tumor biology. Frontiers in Bioscience : a Journal and Virtual Library. 12: 2761-71. PMID 17127278 DOI: 10.2741/2270 |
0.387 |
|
| 2007 |
Zhang X, Winkles JA, Gongora MC, Polavarapu R, Michaelson JS, Hahm K, Burkly L, Friedman M, Li XJ, Yepes M. TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 534-44. PMID 16835630 DOI: 10.1038/Sj.Jcbfm.9600368 |
0.337 |
|
| 2006 |
Yepes M, Winkles JA. Inhibition of TWEAK activity as a new treatment for inflammatory and degenerative diseases. Drug News & Perspectives. 19: 589-95. PMID 17299600 DOI: 10.1358/Dnp.2006.19.10.1068005 |
0.444 |
|
| 2006 |
Girgenrath M, Weng S, Kostek CA, Browning B, Wang M, Brown SA, Winkles JA, Michaelson JS, Allaire N, Schneider P, Scott ML, Hsu YM, Yagita H, Flavell RA, Miller JB, et al. TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. The Embo Journal. 25: 5826-39. PMID 17124496 DOI: 10.1038/Sj.Emboj.7601441 |
0.441 |
|
| 2006 |
Tran NL, McDonough WS, Savitch BA, Fortin SP, Winkles JA, Symons M, Nakada M, Cunliffe HE, Hostetter G, Hoelzinger DB, Rennert JL, Michaelson JS, Burkly LC, Lipinski CA, Loftus JC, et al. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. Cancer Research. 66: 9535-42. PMID 17018610 DOI: 10.1158/0008-5472.Can-06-0418 |
0.51 |
|
| 2006 |
Salhia B, Tran NL, Symons M, Winkles JA, Rutka JT, Berens ME. Molecular pathways triggering glioma cell invasion. Expert Review of Molecular Diagnostics. 6: 613-26. PMID 16824034 DOI: 10.1586/14737159.6.4.613 |
0.33 |
|
| 2006 |
Brown SAN, Hanscom HN, Vu H, Brew SA, Winkles JA. TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules Biochemical Journal. 397: 297-304. PMID 16526941 DOI: 10.1042/Bj20051362 |
0.345 |
|
| 2006 |
Winkles JA, Tran NL, Berens ME. TWEAK and Fn14: new molecular targets for cancer therapy? Cancer Letters. 235: 11-7. PMID 15885893 DOI: 10.1016/j.canlet.2005.03.048 |
0.304 |
|
| 2005 |
Polavarapu R, Gongora MC, Winkles JA, Yepes M. Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through nuclear factor-kappa B pathway activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10094-100. PMID 16267216 DOI: 10.1523/Jneurosci.3382-05.2005 |
0.435 |
|
| 2005 |
Felli N, Pedini F, Zeuner A, Petrucci E, Testa U, Conticello C, Biffoni M, Di Cataldo A, Winkles JA, Peschle C, De Maria R. Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of erythropoiesis. Journal of Immunology (Baltimore, Md. : 1950). 175: 1464-72. PMID 16034083 |
0.303 |
|
| 2005 |
Yepes M, Brown SA, Moore EG, Smith EP, Lawrence DA, Winkles JA. A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia. The American Journal of Pathology. 166: 511-20. PMID 15681834 DOI: 10.1016/S0002-9440(10)62273-0 |
0.402 |
|
| 2005 |
Winkles JA, Alberts GF. Differential regulation of polo-like kinase 1, 2, 3, and 4 gene expression in mammalian cells and tissues. Oncogene. 24: 260-6. PMID 15640841 DOI: 10.1038/sj.onc.1208219 |
0.788 |
|
| 2005 |
Tran NL, McDonough WS, Savitch BA, Sawyer TF, Winkles JA, Berens ME. The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression. The Journal of Biological Chemistry. 280: 3483-92. PMID 15611130 DOI: 10.1074/Jbc.M409906200 |
0.491 |
|
| 2004 |
Ho DH, Vu H, Brown SA, Donohue PJ, Hanscom HN, Winkles JA. Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice. Cancer Research. 64: 8968-72. PMID 15604260 DOI: 10.1158/0008-5472.Can-04-1879 |
0.502 |
|
| 2004 |
Alberts GF, Winkles JA. Murine FGF-inducible kinase is rapidly degraded via the nuclear ubiquitin-proteosome system when overexpressed in NIH 3T3 cells. Cell Cycle (Georgetown, Tex.). 3: 678-84. PMID 15107614 DOI: 10.4161/Cc.3.5.865 |
0.774 |
|
| 2003 |
Tanabe K, Bonilla I, Winkles JA, Strittmatter SM. Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9675-86. PMID 14573547 DOI: 10.1523/Jneurosci.23-29-09675.2003 |
0.31 |
|
| 2003 |
Wiley SR, Winkles JA. TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine & Growth Factor Reviews. 14: 241-9. PMID 12787562 DOI: 10.1016/S1359-6101(03)00019-4 |
0.45 |
|
| 2003 |
Tran NL, McDonough WS, Donohue PJ, Winkles JA, Berens TJ, Ross KR, Hoelzinger DB, Beaudry C, Coons SW, Berens ME. The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors. The American Journal of Pathology. 162: 1313-21. PMID 12651623 DOI: 10.1016/S0002-9440(10)63927-2 |
0.509 |
|
| 2003 |
Donohue PJ, Richards CM, Brown SA, Hanscom HN, Buschman J, Thangada S, Hla T, Williams MS, Winkles JA. TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 594-600. PMID 12615668 DOI: 10.1161/01.Atv.0000062883.93715.37 |
0.476 |
|
| 2003 |
Brown SA, Richards CM, Hanscom HN, Feng SL, Winkles JA. The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation. The Biochemical Journal. 371: 395-403. PMID 12529173 DOI: 10.1042/Bj20021730 |
0.458 |
|
| 2002 |
Guo Y, Hsu DK, Feng SL, Richards CM, Winkles JA. Polypeptide growth factors and phorbol ester induce progressive ankylosis (ank) gene expression in murine and human fibroblasts. Journal of Cellular Biochemistry. 84: 27-38. PMID 11746513 DOI: 10.1002/Jcb.1263 |
0.601 |
|
| 2001 |
Wiley SR, Cassiano L, Lofton T, Davis-Smith T, Winkles JA, Lindner V, Liu H, Daniel TO, Smith CA, Fanslow WC. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity. 15: 837-46. PMID 11728344 DOI: 10.1016/S1074-7613(01)00232-1 |
0.424 |
|
| 2000 |
Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, Peifley KA, Winkles JA. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. The American Journal of Pathology. 156: 1253-61. PMID 10751351 DOI: 10.1016/S0002-9440(10)64996-6 |
0.523 |
|
| 1999 |
Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA. The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. The Journal of Biological Chemistry. 274: 33166-76. PMID 10551889 DOI: 10.1074/jbc.274.46.33166 |
0.797 |
|
| 1999 |
Ho HTB, Jenkins NA, Copeland NG, Gilbert DJ, Winkles JA, Louie HWY, Lee FK, Chung SSM, Chung SK. Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes European Journal of Biochemistry. 259: 726-730. PMID 10092857 DOI: 10.1046/J.1432-1327.1999.00110.X |
0.327 |
|
| 1998 |
Chase D, Feng Y, Hanshew B, Winkles JA, Longo DL, Ferris DK. Expression and phosphorylation of fibroblast-growth-factor-inducible kinase (Fnk) during cell-cycle progression. The Biochemical Journal. 655-60. PMID 9677325 DOI: 10.1042/Bj3330655 |
0.438 |
|
| 1998 |
Grieb TW, Ring M, Brown E, Palmer C, Belle N, Donjerkovic D, Chang H, Yun J, Subramanian R, Forozan F, Guo Y, Vertes A, Winkles JA, Burgess WH. Primary structure of ovine fibroblast growth factor-1 deduced by protein and cDNA analysis. Biochemical and Biophysical Research Communications. 246: 182-91. PMID 9600090 DOI: 10.1006/Bbrc.1998.8597 |
0.429 |
|
| 1998 |
Peifley KA, Winkles JA. Angiotensin II and endothelin-1 increase fibroblast growth factor-2 mRNA expression in vascular smooth muscle cells. Biochemical and Biophysical Research Communications. 242: 202-8. PMID 9439636 DOI: 10.1006/Bbrc.1997.7940 |
0.451 |
|
| 1998 |
Hsu DK, Guo Y, Peifley KA, Winkles JA. Differential control of murine aldose reductase and fibroblast growth factor (FGF)-regulated-1 gene expression in NIH 3T3 cells by FGF-1 treatment and hyperosmotic stress. The Biochemical Journal. 593-8. PMID 9371720 DOI: 10.1042/BJ3280593 |
0.471 |
|
| 1997 |
Winkles JA, Alberts GF, Chedid M, Taylor WG, DeMartino S, Rubin JS. Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries. Journal of Cellular Physiology. 173: 380-6. PMID 9369951 DOI: 10.1002/(Sici)1097-4652(199712)173:3<380::Aid-Jcp10>3.0.Co;2-G |
0.809 |
|
| 1997 |
Winkles JA. Serum- and polypeptide growth factor-inducible gene expression in mouse fibroblasts. Progress in Nucleic Acid Research and Molecular Biology. 58: 41-78. PMID 9308363 DOI: 10.1016/S0079-6603(08)60033-1 |
0.55 |
|
| 1997 |
Donohue PJ, Hsu DK, Guo Y, Burgess WH, Winkles JA. Fibroblast growth factor-1 induction of delayed-early mRNA expression in NIH 3T3 cells is prolonged by heparin addition. Experimental Cell Research. 234: 139-46. PMID 9223379 DOI: 10.1006/Excr.1997.3598 |
0.545 |
|
| 1997 |
Ananyeva NM, Tjuimin AV, Berliner JA, Chisolm GM, Liau G, Winkles JA, Haudenschild CC. Oxidized LDL mediates the release of fibroblast growth factor-1 Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 445-453. PMID 9102162 DOI: 10.1161/01.Atv.17.3.445 |
0.428 |
|
| 1996 |
Winkles JA, Alberts GF, Peifley KA, Nomoto K, Liau G, Majesky MW. Postnatal regulation of fibroblast growth factor ligand and receptor gene expression in rat thoracic aorta American Journal of Pathology. 149: 2119-2131. PMID 8952544 |
0.788 |
|
| 1996 |
Donohue PJ, Feng SL, Alberts GF, Guo Y, Peifley KA, Hsu DK, Winkles JA. Fibroblast growth factor-1 stimulation of quiescent NIH 3T3 cells increases G/T mismatch-binding protein expression. The Biochemical Journal. 319: 9-12. PMID 8870641 DOI: 10.1042/Bj3190009 |
0.797 |
|
| 1996 |
Peifley KA, Alberts GF, Hsu DK, Feng SL, Winkles JA. Heparin-binding epidermal growth factor-like growth factor regulates fibroblast growth factor-2 expression in aortic smooth muscle cells. Circulation Research. 79: 263-70. PMID 8756003 |
0.81 |
|
| 1996 |
Hsu DK, Guo Y, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Peifley KA, Winkles JA. Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation. The Journal of Biological Chemistry. 271: 13786-95. PMID 8662936 DOI: 10.1074/Jbc.271.23.13786 |
0.816 |
|
| 1996 |
Hsu DK, Guo Y, Alberts GF, Peifley KA, Winkles JA. Fibroblast growth factor-1-inducible gene FR-17 encodes a nonmuscle alpha-actinin isoform. Journal of Cellular Physiology. 167: 261-8. PMID 8613466 DOI: 10.1002/(Sici)1097-4652(199605)167:2<261::Aid-Jcp9>3.0.Co;2-N |
0.801 |
|
| 1995 |
Donohue PJ, Alberts GF, Guo Y, Winkles JA. Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. The Journal of Biological Chemistry. 270: 10351-7. PMID 7730342 DOI: 10.1074/Jbc.270.17.10351 |
0.8 |
|
| 1995 |
Chotani MA, Payson RA, Winkles JA, Chiu IM. Human fibroblast growth factor 1 gene expression in vascular smooth muscle cells is modulated via an alternate promoter in response to serum and phorbol ester. Nucleic Acids Research. 23: 434-41. PMID 7533902 DOI: 10.1093/NAR/23.3.434 |
0.431 |
|
| 1995 |
Burgess WH, Friesel R, Winkles JA. Structure-function studies of FGF-1: dissociation and partial reconstitution of certain of its biological activities. Molecular Reproduction and Development. 39: 56-60; discussion 60. PMID 7528028 DOI: 10.1002/Mrd.1080390110 |
0.467 |
|
| 1994 |
Alberts GF, Peifley KA, Johns A, Kleha JF, Winkles JA. Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop. The Journal of Biological Chemistry. 269: 10112-8. PMID 8144511 |
0.765 |
|
| 1994 |
Liau G, Winkles JA, Cannon MS, Kuo L, Chilian WM. Dietary-induced atherosclerotic lesions have increased levels of acidic FGF mRNA and altered cytoskeletal and extracellular matrix mRNA expression. Journal of Vascular Research. 30: 327-32. PMID 7694665 DOI: 10.1159/000159014 |
0.355 |
|
| 1994 |
Gray JL, Kang SS, Zenni GC, Kim DU, Kim PI, Burgess WH, Drohan W, Winkles JA, Haudenschild CC, Greisler HP. FGF-1 Affixation Stimulates ePTFE Endothelialization without Intimal Hyperplasia Journal of Surgical Research. 57: 596-612. PMID 7526046 DOI: 10.1006/Jsre.1994.1189 |
0.363 |
|
| 1994 |
Alberts GF, Hsu DK, Peifley KA, Winkles JA. Differential regulation of acidic and basic fibroblast growth factor gene expression in fibroblast growth factor-treated rat aortic smooth muscle cells. Circulation Research. 75: 261-7. PMID 7518361 DOI: 10.1161/01.Res.75.2.261 |
0.814 |
|
| 1994 |
Donohue PJ, Alberts GF, Hampton BS, Winkles JA. A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase. The Journal of Biological Chemistry. 269: 8604-9. PMID 7510692 |
0.807 |
|
| 1993 |
Winkles JA, Alberts GF, Brogi E, Libby P. Endothelin-1 and endothelin receptor mRNA expression in normal and atherosclerotic human arteries. Biochemical and Biophysical Research Communications. 191: 1081-8. PMID 8466485 DOI: 10.1006/bbrc.1993.1327 |
0.775 |
|
| 1993 |
Winkles JA, Friesel R, Alberts GF, Janat MF, Liau G. Elevated expression of basic fibroblast growth factor in an immortalized rabbit smooth muscle cell line. The American Journal of Pathology. 143: 518-27. PMID 8342599 |
0.775 |
|
| 1993 |
Brogi E, Winkles JA, Underwood R, Clinton SK, Alberts GF, Libby P. Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages. The Journal of Clinical Investigation. 92: 2408-18. PMID 7693761 DOI: 10.1172/JCI116847 |
0.776 |
|
| 1993 |
Hsu DK, Donohue PJ, Alberts GF, Winkles JA. Fibroblast growth factor-1 induces phosphofructokinase, fatty acid synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells. Biochemical and Biophysical Research Communications. 197: 1483-91. PMID 7506544 DOI: 10.1006/Bbrc.1993.2644 |
0.809 |
|
| 1991 |
Winkles JA, Gay CG. Regulated expression of PDGF A-chain mRNA in human saphenous vein smooth muscle cells. Biochemical and Biophysical Research Communications. 180: 519-24. PMID 1953722 DOI: 10.1016/S0006-291X(05)81095-2 |
0.456 |
|
| 1991 |
Gay CG, Winkles JA. Interleukin 1 regulates heparin-binding growth factor 2 gene expression in vascular smooth muscle cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 296-300. PMID 1898777 DOI: 10.1073/Pnas.88.1.296 |
0.471 |
|
| 1991 |
Burgess WH, Shaheen AM, Hampton B, Donohue PJ, Winkles JA. Structure-function studies of heparin-binding (acidic fibroblast) growth factor-1 using site-directed mutagenesis. Journal of Cellular Biochemistry. 45: 131-8. PMID 1711526 DOI: 10.1002/jcb.240450203 |
0.359 |
|
| 1991 |
Gay CG, Winkles JA. The half-lives of platelet-derived growth factor A- and B-chain mRNAs are similar in endothelial cells and unaffected by heparin-binding growth factor-1 or cycloheximide. Journal of Cellular Physiology. 147: 121-7. PMID 1709940 DOI: 10.1002/JCP.1041470116 |
0.398 |
|
| 1990 |
Winkles JA, O'Connor ML, Friesel R. Altered regulation of platelet-derived growth factor A-chain and c-fos gene expression in senescent progeria fibroblasts. Journal of Cellular Physiology. 144: 313-25. PMID 2166059 DOI: 10.1002/Jcp.1041440218 |
0.35 |
|
| 1990 |
Burgess WH, Shaheen AM, Ravera M, Jaye M, Donohue PJ, Winkles JA. Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue. The Journal of Cell Biology. 111: 2129-38. PMID 1699952 DOI: 10.1083/JCB.111.5.2129 |
0.36 |
|
| 1987 |
Winkles JA, Friesel R, Burgess WH, Howk R, Mehlman T, Weinstein R, Maciag T. Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor). Proceedings of the National Academy of Sciences of the United States of America. 84: 7124-8. PMID 2444975 DOI: 10.1073/Pnas.84.20.7124 |
0.465 |
|
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