Hidekazu Tsukamoto - Publications

Affiliations: 
University of Southern California, Los Angeles, CA, United States 
Area:
Cell Biology

203 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Gutierrez V, Kim-Vasquez D, Shum M, Yang Q, Dikeman D, Louie SG, Shirihai OS, Tsukamoto H, Liesa M. The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis. Redox Biology. 70: 103052. PMID 38290384 DOI: 10.1016/j.redox.2024.103052  0.388
2022 Balog S, Fujiwara R, Pan SQ, El-Baradie KB, Choi HY, Sinha S, Yang Q, Asahina K, Chen Y, Li M, Salomon M, Ng SW, Tsukamoto H. Emergence of highly profibrotic and proinflammatory Lrat Fbln2 hepatic stellate cell subpopulation in alcoholic hepatitis. Hepatology (Baltimore, Md.). PMID 36181700 DOI: 10.1002/hep.32793  0.363
2022 Osna NA, Eguchi A, Feldstein AE, Tsukamoto H, Dagur RS, Ganesan M, New-Aaron M, Arumugam MK, Chava S, Ribeiro M, Szabo G, Mueller S, Wang S, Chen C, Weinman SA, et al. Cell-to-Cell Communications in Alcohol-Associated Liver Disease. Frontiers in Physiology. 13: 831004. PMID 35264978 DOI: 10.3389/fphys.2022.831004  0.416
2020 Wu R, Pan S, Chen Y, Nakano Y, Li M, Balog S, Tsukamoto H. Fate and functional roles of Prominin 1 cells in liver injury and cancer. Scientific Reports. 10: 19412. PMID 33173221 DOI: 10.1038/s41598-020-76458-8  0.335
2020 Kim DJ, Jeong WI, Tsukamoto H, Gao B. The 14th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ISALPDC). Clinical and Molecular Hepatology. 26: 584-585. PMID 33053933 DOI: 10.3350/cmh.2020.0271  0.321
2020 Eguchi A, Yan R, Pan SQ, Wu R, Kim J, Chen Y, Ansong C, Smith RD, Tempaku M, Ohno-Machado L, Takei Y, Feldstein AE, Tsukamoto H. Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice. Journal of Molecular Medicine (Berlin, Germany). PMID 32556367 DOI: 10.1007/S00109-020-01926-7  0.397
2020 Choi HY, Siddique HR, Zheng M, Kou Y, Yeh DW, Machida T, Chen CL, Uthaya Kumar DB, Punj V, Winer P, Pita A, Sher L, Tahara SM, Ray RB, Liang C, ... ... Tsukamoto H, et al. p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs. Nature Communications. 11: 3084. PMID 32555153 DOI: 10.1038/S41467-020-16616-8  0.42
2020 Liu X, Rosenthal SB, Meshgin N, Baglieri J, Musallam SG, Diggle K, Lam K, Wu R, Pan SQ, Chen Y, Dorko K, Presnell S, Benner C, Hosseini M, Tsukamoto H, et al. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Hepatology Communications. 4: 606-626. PMID 32258954 DOI: 10.1002/hep4.1483  0.366
2020 Marrero I, Maricic I, Morgan TR, Stolz AA, Schnabl B, Liu ZX, Tsukamoto H, Kumar V. Differential activation of unconventional T cells, including iNKT cells, in alcohol-related liver disease. Alcoholism, Clinical and Experimental Research. PMID 32154597 DOI: 10.1111/Acer.14323  0.43
2020 Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, ... ... Tsukamoto H, et al. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. Jci Insight. 5. PMID 32051339 DOI: 10.1172/Jci.Insight.131277  0.402
2020 Hyun J, Sun Z, Ahmadi AR, Bangru S, Chembazhi UV, Du K, Chen T, Tsukamoto H, Rusyn I, Kalsotra A, Diehl AM. Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. The Journal of Clinical Investigation. PMID 31945016 DOI: 10.1172/Jci132691  0.489
2019 Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, ... ... Tsukamoto H, et al. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. Journal of Hepatology. PMID 31899206 DOI: 10.1016/J.Jhep.2019.12.016  0.384
2019 Kikuchi K, Tsukamoto H. Stearoyl-CoA desaturase and tumorigenesis. Chemico-Biological Interactions. 316: 108917. PMID 31838050 DOI: 10.1016/J.Cbi.2019.108917  0.461
2019 Asahina K, Balog S, Hwang E, Moon E, Wan E, Skrypek K, Chen Y, Fernandez J, Romo J, Yang Q, Lai K, French SW, Tsukamoto H. Moderate Alcohol Intake Promotes Pancreatic Ductal Adenocarcinoma Development in Mice Expressing Oncogenic Kras. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31760766 DOI: 10.1152/Ajpgi.00218.2019  0.389
2019 Aizawa S, Brar G, Tsukamoto H. Cell Death and Liver Disease. Gut and Liver. PMID 30917630 DOI: 10.5009/Gnl18486  0.371
2019 Gao B, Ahmad MF, Nagy LE, Tsukamoto H. Inflammatory pathways in alcoholic steatohepatitis. Journal of Hepatology. 70: 249-259. PMID 30658726 DOI: 10.1016/J.Jhep.2018.10.023  0.402
2019 Brar G, Tsukamoto H. Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science. Journal of Gastroenterology. PMID 30643981 DOI: 10.1007/S00535-018-01542-W  0.403
2018 Kuprys PV, Tsukamoto H, Gao B, Jia L, McGowan J, Coopersmith CM, Moreno MC, Hulsebus H, Meena AS, Souza-Smith FM, Roper P, Foster MT, Raju SV, Marshall SA, Fujita M, et al. Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol (Fayetteville, N.Y.). 77: 11-18. PMID 30763905 DOI: 10.1016/J.Alcohol.2018.08.010  0.355
2018 Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. Alcoholic liver disease. Nature Reviews. Disease Primers. 4: 16. PMID 30115921 DOI: 10.1038/s41572-018-0014-7  0.381
2018 Wu R, Murali R, Kabe Y, French SW, Chiang YM, Liu S, Sher L, Wang CC, Louie S, Tsukamoto H. Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition. Hepatology (Baltimore, Md.). PMID 29729190 DOI: 10.1002/Hep.30071  0.388
2018 Tsukamoto H. Current Understanding of Alcoholic Liver Disease: A prevalent "hidden" disease of increasing clinical importance Kanzo. 59: 319-341. DOI: 10.2957/Kanzo.59.319  0.391
2018 Machida K, Siddique HR, Zheng M, Winer P, Kumar DBU, Rokan A, Sher L, Tahara SM, Elowitz M, Liang C, Tsukamoto H. Abstract 1984: Cell fate reprogramming of liver tumor-initiating stem-like cells via phosphorylated NUMB and TBC1D15 Cancer Research. 78: 1984-1984. DOI: 10.1158/1538-7445.Am2018-1984  0.452
2017 Khanova E, Wu R, Wang W, Yan R, Chen Y, French SW, Llorente C, Pan SQ, Yang Q, Li Y, Lazaro R, Ansong C, Smith RD, Bataller R, Morgan T, ... ... Tsukamoto H, et al. Pyroptosis by Caspase11/4-Gasdermin-D Pathway in Alcoholic Hepatitis. Hepatology (Baltimore, Md.). PMID 29108122 DOI: 10.1002/Hep.29645  0.501
2017 Baulies A, Montero J, Matías N, Insausti N, Terrones O, Basañez G, Vallejo C, de La Rosa LC, Martinez L, Robles D, Morales A, Abian J, Carrascal M, Machida K, Kumar DBU, ... Tsukamoto H, et al. The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. Redox Biology. 14: 164-177. PMID 28942194 DOI: 10.1016/J.Redox.2017.08.022  0.353
2017 Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1. Plos One. 12: e0181052. PMID 28797077 DOI: 10.1371/Journal.Pone.0181052  0.344
2017 McDaniel K, Huang L, Sato K, Wu N, Annable T, Zhou T, Ramos-Lorenzo S, Wan Y, Huang Q, Francis H, Glaser S, Tsukamoto H, Alpini G, Meng F. The let-7/lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury. The Journal of Biological Chemistry. PMID 28536261 DOI: 10.1074/Jbc.M116.773291  0.496
2017 Yang Z, Liu Y, Qin L, Wu P, Xia Z, Luo M, Zheng Y, Tsukamoto H, Ju Z, Su D, Kang H, Xiao Z, Zheng S, Duan Z, Hu R, et al. Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases. The American Journal of Pathology. PMID 28157489 DOI: 10.1016/J.Ajpath.2016.12.001  0.343
2017 Lai KK, Kweon SM, Chi F, Hwang E, Kabe Y, Higashiyama R, Qin L, Yan R, Wu RP, Fujii N, French S, Xu J, Wang JY, Murali R, Mishra L, ... ... Tsukamoto H, et al. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via Wnt Signaling and Stabilization of Low Density Lipoprotein Receptor-related Proteins 5 and 6. Gastroenterology. PMID 28143772 DOI: 10.1053/J.Gastro.2017.01.021  0.405
2017 Zeybel M, Luli S, Sabater L, Hardy T, Oakley F, Leslie J, Page A, Moran Salvador E, Sharkey V, Tsukamoto H, Chu DC, Singh US, Ponzoni M, Perri P, Di Paolo D, et al. A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Molecular Therapy : the Journal of the American Society of Gene Therapy. 25: 218-231. PMID 28129116 DOI: 10.1016/J.Ymthe.2016.10.004  0.4
2017 Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong LN, Katz LH, Shetty K, Rashid A, Su X, White J, Li L, Wang AY, Blechacz B, Raju GS, ... ... Tsukamoto H, et al. Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability. Hepatology (Baltimore, Md.). 65: 678-693. PMID 28114741 DOI: 10.1002/Hep.28927  0.33
2017 Lai K, Kweon S, Chi F, Hwang E, Wu R, Kabe Y, Murali R, Mishra L, Ntambi J, Tsukamoto H. Abstract 4331: Novel Wnt-SCD-LRP5/6 pathway linking liver fibrosis to cancer Cancer Research. 77: 4331-4331. DOI: 10.1158/1538-7445.Am2017-4331  0.386
2017 Wan Y, McDaniel KM, Wu N, Ramos-Lorenzo S, Zhou T, Sato K, Venter J, Francis HL, Glaser S, Tsukamoto H, Alpini G, Meng F. Characterization of Endothelial Dysfunction in Microrna-34A Knockout Mice with Alcoholic Liver Injury Gastroenterology. 152: S1111. DOI: 10.1016/S0016-5085(17)33741-1  0.384
2016 Su D, Nie Y, Zhu A, Chen Z, Wu P, Zhang L, Luo M, Sun Q, Cai L, Lai Y, Xiao Z, Duan Z, Zheng S, Wu G, Hu R, ... Tsukamoto H, et al. Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. Frontiers in Physiology. 7: 498. PMID 27895587 DOI: 10.3389/Fphys.2016.00498  0.39
2016 Eguchi A, Lazaro RG, Wang J, Kim J, Povero D, Willliams B, Ho SB, Stärkel P, Schnabl B, Ohno-Machado L, Tsukamoto H, Feldstein AE. Extracellular vesicles released by hepatocytes from gastric infusion model of ALD contain a miRNA barcode that can be detected in blood. Hepatology (Baltimore, Md.). PMID 27639178 DOI: 10.1002/Hep.28838  0.321
2016 Harrall KK, Kechris KJ, Tabakoff B, Hoffman PL, Hines LM, Tsukamoto H, Pravenec M, Printz M, Saba LM. Uncovering the liver's role in immunity through RNA co-expression networks. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 27401171 DOI: 10.1007/S00335-016-9656-5  0.335
2016 Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Current Pathobiology Reports. 4: 27-35. PMID 27239399 DOI: 10.1007/S40139-016-0097-3  0.45
2016 Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. Plos One. 11: e0156111. PMID 27214381 DOI: 10.1371/Journal.Pone.0156111  0.335
2016 Puri P, Xu J, Vihervaara T, Katainen R, Ekroos K, Daita K, Min HK, Joyce A, Mirshahi F, Tsukamoto H, Sanyal AJ. Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese. Journal of Lipid Research. PMID 27020313 DOI: 10.1194/Jlr.M066175  0.343
2016 Mandrekar P, Bataller R, Tsukamoto H, Gao B. Alcoholic hepatitis: Translational approaches to develop targeted therapies. Hepatology (Baltimore, Md.). PMID 26940353 DOI: 10.1002/Hep.28530  0.433
2016 Gao B, Tsukamoto H. Inflammation in alcoholic and nonalcoholic fatty liver disease: friend or foe? Gastroenterology. PMID 26826669 DOI: 10.1053/J.Gastro.2016.01.025  0.445
2016 Chen J, Shukla V, Chen J, Panditab RK, Jeong YS, Katz LH, Shin J, Gi Y, Kwongc LN, Huntb CR, Farci P, Su X, White J, Mishra B, Rashid A, ... ... Tsukamoto H, et al. Abstract 3594: The TGF-β effector β2SP depletion abrogates DNA damage repair Cancer Research. 76: 3594-3594. DOI: 10.1158/1538-7445.Am2016-3594  0.386
2016 Chen J, Yao Z, Chen J, Gi YJ, Jeong YS, Jogunoori W, Belkin M, Mishra B, White J, Mitra A, Li S, Finegold M, Davila M, Shay J, Machida K, ... Tsukamoto H, et al. Abstract 2540: Disruption of a TGF-β-CTCF regulated pathway leads to cancer stem cells Cancer Research. 76: 2540-2540. DOI: 10.1158/1538-7445.Am2016-2540  0.313
2016 Chen J, Shukla V, Panditab RK, Chen J, Jeong YS, Katz LH, Shin J, Gi Y, Kwongc LN, Huntb CR, Farci P, Su X, White J, Mishra B, Rashid A, ... ... Tsukamoto H, et al. Tu1624 Dysregulated TGF-β Signaling Leads to Genomic Instability and Liver Cancer Gastroenterology. 150: S1152. DOI: 10.1016/S0016-5085(16)33888-4  0.325
2015 Fung E, Tsukamoto H. Morphogen-related therapeutic targets for liver fibrosis. Clinics and Research in Hepatology and Gastroenterology. 39: S69-74. PMID 26206577 DOI: 10.1016/J.Clinre.2015.05.017  0.497
2015 Xu J, Chi F, Tsukamoto H. Notch signaling and M1 macrophage activation in obesity-alcohol synergism. Clinics and Research in Hepatology and Gastroenterology. 39: S24-8. PMID 26189984 DOI: 10.1016/J.Clinre.2015.05.016  0.378
2015 Xu S, Chheda C, Ouhaddi Y, Benhaddou H, Bourhim M, Grippo PJ, Principe DR, Mascariñas E, DeCant B, Tsukamoto H, Pandol SJ, Edderkaoui M. Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis. Pancreas. 44: 882-7. PMID 26166469 DOI: 10.1097/Mpa.0000000000000380  0.396
2015 Tsukamoto H. Metabolic reprogramming and cell fate regulation in alcoholic liver disease. Pancreatology : Official Journal of the International Association of Pancreatology (Iap) ... [Et Al.]. 15: S61-5. PMID 25800177 DOI: 10.1016/J.Pan.2015.03.003  0.486
2015 Xu J, Chi F, Guo T, Punj V, Lee WN, French SW, Tsukamoto H. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. The Journal of Clinical Investigation. 125: 1579-90. PMID 25798621 DOI: 10.1172/Jci76468  0.364
2015 Zhao N, Nizzi CP, Anderson SA, Wang J, Ueno A, Tsukamoto H, Eisenstein RS, Enns CA, Zhang AS. Low intracellular iron increases the stability of matriptase-2. The Journal of Biological Chemistry. 290: 4432-46. PMID 25550162 DOI: 10.1074/Jbc.M114.611913  0.319
2015 Page A, Paoli PP, Hill SJ, Howarth R, Wu R, Kweon SM, French J, White S, Tsukamoto H, Mann DA, Mann J. Alcohol directly stimulates epigenetic modifications in hepatic stellate cells. Journal of Hepatology. 62: 388-97. PMID 25457206 DOI: 10.1016/J.Jhep.2014.09.033  0.473
2015 Machida K, Feldman DE, Tsukamoto H. TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis. Advances in Experimental Medicine and Biology. 815: 131-44. PMID 25427905 DOI: 10.1007/978-3-319-09614-8_8  0.429
2015 Chen P, Torralba M, Tan J, Embree M, Zengler K, Stärkel P, van Pijkeren JP, DePew J, Loomba R, Ho SB, Bajaj JS, Mutlu EA, Keshavarzian A, Tsukamoto H, Nelson KE, et al. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology. 148: 203-214.e16. PMID 25239591 DOI: 10.1053/J.Gastro.2014.09.014  0.46
2015 Lazaro R, Wu R, Lee S, Zhu NL, Chen CL, French SW, Xu J, Machida K, Tsukamoto H. Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. Hepatology (Baltimore, Md.). 61: 129-40. PMID 25132354 DOI: 10.1002/Hep.27383  0.428
2015 Shin J, Katz LH, Munoz NM, Cortes A, Shukla V, Kim S, Herlong F, Machida K, Tsukamoto H, Shetty K, He AR, Johnson LB, Rashid A, Chen J, Lee J, et al. Abstract 892: Vitamin D deficiency regulates TLR7 to promote hepatocellular cancer in TGF-β/Smad3 heterozygous mice Cancer Research. 75: 892-892. DOI: 10.1158/1538-7445.Am2015-892  0.358
2014 Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. New Approaches for Studying Alcoholic Liver Disease. Current Pathobiology Reports. 2: 171-183. PMID 26594598 DOI: 10.1007/S40139-014-0053-Z  0.516
2014 Chen CL, Tsukamoto H, Machida K. Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. Hepatology International. 8: 330-8. PMID 26202636 DOI: 10.1007/S12072-014-9545-5  0.429
2014 Tsukamoto H, Mishra L, Machida K. Alcohol, TLR4-TGF-β antagonism, and liver cancer. Hepatology International. 8: 408-12. PMID 26201318 DOI: 10.1007/S12072-013-9489-1  0.476
2014 Medici V, Schroeder DI, Woods R, LaSalle JM, Geng Y, Shibata NM, Peerson J, Hodzic E, Dayal S, Tsukamoto H, Kharbanda KK, Tillman B, French SW, Halsted CH. Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. Alcoholism, Clinical and Experimental Research. 38: 1540-9. PMID 24730561 DOI: 10.1111/Acer.12405  0.373
2014 Chen L, Charrier A, Zhou Y, Chen R, Yu B, Agarwal K, Tsukamoto H, Lee LJ, Paulaitis ME, Brigstock DR. Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology (Baltimore, Md.). 59: 1118-29. PMID 24122827 DOI: 10.1002/Hep.26768  0.307
2014 Kagawa T, Orii R, Hirose S, Arase Y, Shiraishi K, Mizutani A, Tsukamoto H, Mine T. Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells Journal of Gastroenterology. 49: 890-899. PMID 23722250 DOI: 10.1007/S00535-013-0833-Y  0.334
2014 Edderkaoui M, Grippo P, Benhaddou H, Ouhaddi Y, Tsukamoto H, Swartwood S, Knudsen B, Goodridge HS, Habtezion A, Go V, Pandol SJ. Abstract 4847: Alcoholic chronic pancreatitis increases tissue transformed macrophages (M2) which promote pancreatic cancer lesions in a Kras mouse model Cancer Research. 74: 4847-4847. DOI: 10.1158/1538-7445.Am2014-4847  0.345
2014 Katz LH, Cortes A, Shukla V, Machida K, Tsukamoto H, Shetty K, He AR, Johnson LB, Chen J, El-Zein R, Lee J, Mshra L. Abstract 4111: Vitamin D for prevention of liver cancer in the setting of disrupted TGF-β signaling pathway Cancer Research. 74: 4111-4111. DOI: 10.1158/1538-7445.Am2014-4111  0.354
2014 Muñoz NM, Katz LH, Machida K, Tsukamoto H, Shetty K, He AR, Johnson LB, Rashid A, Kim SB, Lee J, Mishra L. Abstract 248: Vitamin D deficiency promotes hepatocellular carcinoma tumor growth in TGF-β impaired mice by Smad3 heterozygous deletion Cancer Research. 74: 248-248. DOI: 10.1158/1538-7445.Am2014-248  0.347
2014 Chen P, Torralba M, Zengler K, Mutlu E, Keshavarzian A, Tsukamoto H, Nelson KE, Brenner DA, Fouts DE, Schnabl B. 387 Restoration of Intestinal Metabolic Homeostasis Results in Eubiosis and Protects Mice From Alcoholic Liver Disease Gastroenterology. 146: S-911. DOI: 10.1016/S0016-5085(14)63315-1  0.48
2013 Chen CL, Tsukamoto H, Liu JC, Kashiwabara C, Feldman D, Sher L, Dooley S, French SW, Mishra L, Petrovic L, Jeong JH, Machida K. Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. The Journal of Clinical Investigation. 123: 2832-49. PMID 23921128 DOI: 10.1172/Jci65859  0.369
2013 Enns CA, Ahmed R, Wang J, Ueno A, Worthen C, Tsukamoto H, Zhang AS. Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. Plos One. 8: e60534. PMID 23565256 DOI: 10.1371/Journal.Pone.0060534  0.43
2013 Hartmann P, Chen P, Wang HJ, Wang L, McCole DF, Brandl K, Stärkel P, Belzer C, Hellerbrand C, Tsukamoto H, Ho SB, Schnabl B. Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice. Hepatology (Baltimore, Md.). 58: 108-19. PMID 23408358 DOI: 10.1002/Hep.26321  0.418
2013 Chen C, Liu J, Sher L, Mishra L, Tsukamoto H, Machida K. Abstract 4893: ProtooncogenicTLR4induces NANOG-mediated oncogenic signaling via synergistic interaction with STAT3 pathway in experimental and clinical tumor-initiating cells. Cancer Research. 73: 4893-4893. DOI: 10.1158/1538-7445.Am2013-4893  0.431
2013 Tsukamoto H, Stickel F, Seitz H, Rao R, Gangwar R, Samak G, Mir H, Chaudhry K, Manda B, Nagy L, Sood A, Nagy L, Chiang D, Roychowdhury S. S13 * MULTIPLE HITS IN THE PATHOGENESIS OF ALCOHOLIC LIVER DISEASE Alcohol and Alcoholism. 48: i14-i15. DOI: 10.1093/alcalc/agt119  0.318
2013 Levine P, McDaniel K, Han Y, Francis HL, Glaser S, Venter J, Tsukamoto H, Alpini G, Meng F. Su1718 Regulation of MicroRNA-21 by Interleukin-6 During Alcoholic Liver Injury Gastroenterology. 144: S-1005. DOI: 10.1016/S0016-5085(13)63734-8  0.435
2013 Medici V, Schroeder DI, Woods R, LaSalle JM, Dayal S, Tsukamoto H, Kharbanda KK, French SW, Halsted CH. 615 Epigenetic Regulation of iNOS, PPAR-Alpha, and Dnmt1 in the Cystathionine Beta Synthase Deficient Mouse Model of Alcoholic Steatohepatitis Gastroenterology. 144: S-953. DOI: 10.1016/S0016-5085(13)63543-X  0.354
2012 Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Lim AM, Dara L, Cadenas E, Tsukamoto H, Kaplowitz N. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. The Journal of Biological Chemistry. 287: 42165-79. PMID 23086958 DOI: 10.1074/Jbc.M112.377374  0.43
2012 Meng F, Glaser SS, Francis H, Yang F, Han Y, Stokes A, Staloch D, McCarra J, Liu J, Venter J, Zhao H, Liu X, Francis T, Swendsen S, Liu CG, ... Tsukamoto H, et al. Epigenetic regulation of miR-34a expression in alcoholic liver injury. The American Journal of Pathology. 181: 804-17. PMID 22841474 DOI: 10.1016/J.Ajpath.2012.06.010  0.337
2012 Zhong S, Xu J, Li P, Tsukamoto H. Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation. The Journal of Biological Chemistry. 287: 32078-84. PMID 22829592 DOI: 10.1074/Jbc.M112.377358  0.325
2012 von Montfort C, Matias N, Fernandez A, Fucho R, Conde de la Rosa L, Martinez-Chantar ML, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. Journal of Hepatology. 57: 852-9. PMID 22687340 DOI: 10.1016/J.Jhep.2012.05.024  0.322
2012 Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 109: 9448-53. PMID 22566629 DOI: 10.1073/Pnas.1201840109  0.487
2012 Perugorria MJ, Wilson CL, Zeybel M, Walsh M, Amin S, Robinson S, White SA, Burt AD, Oakley F, Tsukamoto H, Mann DA, Mann J. Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation. Hepatology (Baltimore, Md.). 56: 1129-39. PMID 22488473 DOI: 10.1002/Hep.25754  0.364
2012 Ueno A, Lazaro R, Wang PY, Higashiyama R, Machida K, Tsukamoto H. Mouse intragastric infusion (iG) model. Nature Protocols. 7: 771-81. PMID 22461066 DOI: 10.1038/Nprot.2012.014  0.305
2012 Tsukamoto H, Zhu NL, Wang J, Asahina K, Machida K. Morphogens and hepatic stellate cell fate regulation in chronic liver disease. Journal of Gastroenterology and Hepatology. 27: 94-8. PMID 22320925 DOI: 10.1111/J.1440-1746.2011.07022.X  0.496
2012 Machida K, Chen CL, Liu JC, Kashiwabara C, Feldman D, French SW, Sher L, Hyeongnam JJ, Tsukamoto H. Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. Journal of Gastroenterology and Hepatology. 27: 19-22. PMID 22320911 DOI: 10.1111/J.1440-1746.2011.07010.X  0.413
2012 Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, Miyaoka Y, Miyajima A, Tsukamoto H. Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration. The Journal of Biological Chemistry. 287: 10355-67. PMID 22298767 DOI: 10.1074/Jbc.M111.312751  0.484
2012 Feldman DE, Chen C, Punj V, Tsukamoto H, Machida K. Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 829-34. PMID 22207628 DOI: 10.1073/Pnas.1114438109  0.328
2012 Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, Esposito I, Friess H, Gress TM, Habisch HJ, Hwang RF, Jaster R, Kleeff J, Klöppel G, Kordes C, ... ... Tsukamoto H, et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 61: 172-8. PMID 22115911 DOI: 10.1136/Gutjnl-2011-301220  0.309
2012 Yang MD, Chiang YM, Higashiyama R, Asahina K, Mann DA, Mann J, Wang CC, Tsukamoto H. Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect. Hepatology (Baltimore, Md.). 55: 1271-81. PMID 22095555 DOI: 10.1002/Hep.24792  0.471
2012 Machida K, Chen C, Liu J, Sher L, Mishra L, Tsukamoto H. Abstract 1017: ProtooncogenicTLR4generates NANOG-dependent tumor-initiating stem-like cells through LIN28-Let7 pathway in experimental and clinical carcinogenesis Cancer Research. 72: 1017-1017. DOI: 10.1158/1538-7445.Am2012-1017  0.423
2012 Han Y, Glaser S, McCarra J, Venter J, White M, Dusio G, Francis HL, Johnson C, Tsukamoto H, Meng F, Alpini G. 931 Regulation of Hepatic Stem/Progenitor Phenotype by Melatonin During Alcoholic Liver Injury Gastroenterology. 142: S-935. DOI: 10.1016/S0016-5085(12)63629-4  0.434
2012 Johnson C, Francis HL, Glaser S, Han Y, Venter J, Liu C, White M, McCarra J, Tsukamoto H, Alpini G, Meng F. 930 Regulation of Hepatic Stellate Cell Activation by MicroRNA Let-7 Family During Alcoholic Liver Injury Gastroenterology. 142: S-935. DOI: 10.1016/S0016-5085(12)63628-2  0.437
2012 Hartmann P, Brandl K, Hellerbrand C, Tsukamoto H, Ho SB, Beutler B, Schnabl B. 928 Deficiency of Intestinal Mucin-2 Protects From Alcoholic Liver Disease in Mice Gastroenterology. 142: S-935. DOI: 10.1016/S0016-5085(12)63626-9  0.424
2011 DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver International : Official Journal of the International Association For the Study of the Liver. 31: 762-72. PMID 21645207 DOI: 10.1111/J.1478-3231.2011.02527.X  0.427
2011 Tsukamoto H, Zhu NL, Asahina K, Mann DA, Mann J. Epigenetic cell fate regulation of hepatic stellate cells. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 41: 675-82. PMID 21504520 DOI: 10.1111/J.1872-034X.2011.00804.X  0.457
2011 Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcoholism, Clinical and Experimental Research. 35: 1509-18. PMID 21463341 DOI: 10.1111/J.1530-0277.2011.01487.X  0.475
2011 Asahina K, Zhou B, Pu WT, Tsukamoto H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology (Baltimore, Md.). 53: 983-95. PMID 21294146 DOI: 10.1002/Hep.24119  0.459
2011 Xu J, Lai KK, Verlinsky A, Lugea A, French SW, Cooper MP, Ji C, Tsukamoto H. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. Journal of Hepatology. 55: 673-82. PMID 21256905 DOI: 10.1016/J.Jhep.2010.12.034  0.423
2011 Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, Ahmed R, Nizzi CP, Eisenstein RS, Tsukamoto H, Enns CA. Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood. 117: 1687-99. PMID 21115976 DOI: 10.1182/Blood-2010-06-287292  0.423
2011 Machida K, Chen C, Kashiwabara C, Liu J, Feldman D, Hyeongnam JJ, Tsukamoto H. Abstract 2447: Novel TLR4-Nanog stemness pathway in liver cancer stem cells confers resistance to TGF-β-mediated tumor suppression through YAP1 and IGF2BP3-AKT-mTOR Cancer Research. 71: 2447-2447. DOI: 10.1158/1538-7445.Am2011-2447  0.382
2011 Perugorria M, Wilson C, Zeybel M, Amin S, Oakley F, Tsukamoto H, Mann D, Mann J. 1054 EXPRESSION PROFILING OF EPIGENETIC REGULATORS IDENTIFIES ASH1 AS A KEY ACTIVATOR OF PRO-FIBROGENIC GENES Journal of Hepatology. 54: S418. DOI: 10.1016/S0168-8278(11)61056-8  0.309
2010 Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, Lai MM, Akira S, Ou JH. c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology (Baltimore, Md.). 52: 480-92. PMID 20683948 DOI: 10.1002/Hep.23697  0.347
2010 Zhu NL, Wang J, Tsukamoto H. The Necdin-Wnt pathway causes epigenetic peroxisome proliferator-activated receptor gamma repression in hepatic stellate cells. The Journal of Biological Chemistry. 285: 30463-71. PMID 20663865 DOI: 10.1074/Jbc.M110.156703  0.477
2010 Subramanian VS, Subramanya SB, Tsukamoto H, Said HM. Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport. American Journal of Physiology. Renal Physiology. 299: F28-34. PMID 20427470 DOI: 10.1152/Ajprenal.00140.2010  0.337
2010 Ciuclan L, Ehnert S, Ilkavets I, Weng HL, Gaitantzi H, Tsukamoto H, Ueberham E, Meindl-Beinker NM, Singer MV, Breitkopf K, Dooley S. TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I. Journal of Hepatology. 52: 407-16. PMID 20129692 DOI: 10.1016/J.Jhep.2009.12.003  0.404
2010 Ramani K, Yang H, Kuhlenkamp J, Tomasi L, Tsukamoto H, Mato JM, Lu SC. Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation. Hepatology (Baltimore, Md.). 51: 986-95. PMID 20043323 DOI: 10.1002/Hep.23411  0.482
2010 Esfandiari F, Medici V, Wong DH, Jose S, Dolatshahi M, Quinlivan E, Dayal S, Lentz SR, Tsukamoto H, Zhang YH, French SW, Halsted CH. Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse Hepatology. 51: 932-941. PMID 19957376 DOI: 10.1002/Hep.23382  0.43
2010 Mann J, Chu DC, Maxwell A, Oakley F, Zhu NL, Tsukamoto H, Mann DA. MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology. 138: 705-14, 714.e1-4. PMID 19843474 DOI: 10.1053/J.Gastro.2009.10.002  0.413
2010 Machida K, Liu J, Kashiwabara C, Feldman D, Hyeongnam JJ, Mishra L, Tsukamoto H. Abstract 5357: TLR4-dependent Nanog+ cancer stem cells exhibit defective TGF-β signaling through IGF-Akt-Yap1 pathway Cancer Research. 70: 5357-5357. DOI: 10.1158/1538-7445.Am10-5357  0.37
2010 Yan AW, Brandl J, Torralba M, Fouts DE, Schott E, Tsukamoto H, Nelson KE, Brenner DA, Schnabl B. 3 Downregulation of Anti-Microbial Proteins Regenerating Islet-Derived 3 Beta (Reg3b) and Gamma (Reg3g) Contributes to Enteric Dysbiosis in Alcoholic Liver Disease Gastroenterology. 138: S-773. DOI: 10.1016/S0016-5085(10)63564-0  0.404
2009 Yeligar SM, Machida K, Tsukamoto H, Kalra VK. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. Journal of Immunology (Baltimore, Md. : 1950). 183: 5964-76. PMID 19828633 DOI: 10.4049/Jimmunol.0901564  0.406
2009 Yeligar S, Tsukamoto H, Kalra VK. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. Journal of Immunology (Baltimore, Md. : 1950). 183: 5232-43. PMID 19783678 DOI: 10.4049/Jimmunol.0901084  0.362
2009 Zhang AS, Yang F, Wang J, Tsukamoto H, Enns CA. Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. The Journal of Biological Chemistry. 284: 22580-9. PMID 19564337 DOI: 10.1074/Jbc.M109.027318  0.422
2009 Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko K, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E. S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology (Baltimore, Md.). 50: 462-71. PMID 19444874 DOI: 10.1002/Hep.22990  0.391
2009 Tsukamoto H, Machida K, Dynnyk A, Mkrtchyan H. "Second hit" models of alcoholic liver disease. Seminars in Liver Disease. 29: 178-87. PMID 19387917 DOI: 10.1055/S-0029-1214373  0.413
2009 Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metabolism. 9: 217-27. PMID 19254567 DOI: 10.1016/J.Cmet.2009.01.010  0.356
2009 Boros LG, Deng Q, Pandol SJ, Tsukamoto H, Go VL, Lee WN. Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer. Pancreas. 38: e47-52. PMID 19248221 DOI: 10.1097/Mpa.0B013E318199Fea4  0.379
2009 Tatsukawa H, Fukaya Y, Frampton G, Martinez-Fuentes A, Suzuki K, Kuo TF, Nagatsuma K, Shimokado K, Okuno M, Wu J, Iismaa S, Matsuura T, Tsukamoto H, Zern MA, Graham RM, et al. Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. Gastroenterology. 136: 1783-95.e10. PMID 19208340 DOI: 10.1053/J.Gastro.2009.01.007  0.481
2009 Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proceedings of the National Academy of Sciences of the United States of America. 106: 1548-53. PMID 19171902 DOI: 10.1073/Pnas.0807390106  0.486
2009 Asahina K, Tsai SY, Li P, Ishii M, Maxson RE, Sucov HM, Tsukamoto H. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology (Baltimore, Md.). 49: 998-1011. PMID 19085956 DOI: 10.1002/Hep.22721  0.432
2008 Gordeuk VR, Diaz SF, Onojobi GO, Kasvosve I, Debebe Z, Edossa A, Pantin JM, Xiong S, Nekhai S, Nouraie M, Tsukamoto H, Taylor RE. Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption. Alcoholism, Clinical and Experimental Research. 32: 1947-53. PMID 18782341 DOI: 10.1111/J.1530-0277.2008.00782.X  0.302
2008 Mello T, Nakatsuka A, Fears S, Davis W, Tsukamoto H, Bosron WF, Sanghani SP. Expression of carboxylesterase and lipase genes in rat liver cell-types. Biochemical and Biophysical Research Communications. 374: 460-4. PMID 18639528 DOI: 10.1016/J.Bbrc.2008.07.024  0.445
2008 Xiong S, She H, Zhang AS, Wang J, Mkrtchyan H, Dynnyk A, Gordeuk VR, French SW, Enns CA, Tsukamoto H. Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis American Journal of Physiology - Gastrointestinal and Liver Physiology. 295: G512-G521. PMID 18599584 DOI: 10.1152/Ajpgi.90327.2008  0.358
2008 Tsukamoto H, She H, Hazra S, Cheng J, Wang J. Fat paradox of steatohepatitis. Journal of Gastroenterology and Hepatology. 23: S104-7. PMID 18336651 DOI: 10.1111/J.1440-1746.2007.05294.X  0.77
2008 Cheng JH, She H, Han YP, Wang J, Xiong S, Asahina K, Tsukamoto H. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G39-49. PMID 18006602 DOI: 10.1152/Ajpgi.00263.2007  0.494
2007 Gukovsky I, Lugea A, Shahsahebi M, Cheng JH, Hong PP, Jung YJ, Deng QG, French BA, Lungo W, French SW, Tsukamoto H, Pandol SJ. A rat model reproducing key pathological responses of alcoholic chronic pancreatitis American Journal of Physiology - Gastrointestinal and Liver Physiology. 294: G68-G79. PMID 17884979 DOI: 10.1152/Ajpgi.00006.2007  0.402
2007 Tsukamoto H. Conceptual importance of identifying alcoholic liver disease as a lifestyle disease. Journal of Gastroenterology. 42: 603-9. PMID 17701122 DOI: 10.1007/S00535-007-2075-3  0.386
2006 Tsukamoto H, She H, Hazra S, Cheng J, Miyahara T. Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation. Journal of Gastroenterology and Hepatology. 21: S102-5. PMID 16958658 DOI: 10.1111/J.1440-1746.2006.04573.X  0.769
2006 Mareninova OA, Lugea A, Odinokova IV, Tsukamoto H, Gukovsky I, Pandol SJ, Gukovskaya AS. AKT ACTIVATION IN ALCOHOLIC PANCREATITIS Pancreas. 33: 481. DOI: 10.1097/00006676-200611000-00150  0.353
2005 Yavrom S, Chen L, Xiong S, Wang J, Rippe RA, Tsukamoto H. Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells. The Journal of Biological Chemistry. 280: 40650-9. PMID 16216869 DOI: 10.1074/Jbc.M510094200  0.402
2005 Deng QG, She H, Cheng JH, French SW, Koop DR, Xiong S, Tsukamoto H. Steatohepatitis induced by intragastric overfeeding in mice. Hepatology (Baltimore, Md.). 42: 905-14. PMID 16175602 DOI: 10.1002/Hep.20877  0.316
2005 Sussman S, Runyon BA, Hernandez R, Magallanes M, Mendler M, Yuan JM, Tsukamoto H. A pilot study of an alcoholic liver disease recurrence prevention education program in hospitalized patients with advanced liver disease. Addictive Behaviors. 30: 465-73. PMID 15718064 DOI: 10.1016/J.Addbeh.2004.06.016  0.313
2005 She H, Xiong S, Hazra S, Tsukamoto H. Adipogenic transcriptional regulation of hepatic stellate cells. The Journal of Biological Chemistry. 280: 4959-67. PMID 15537655 DOI: 10.1074/Jbc.M410078200  0.75
2005 Tsukamoto H. Activation of Hepatic Stellate Cells: Anti-Adipogenic Differentiation? The Keio Journal of Medicine. 52: 137-144. DOI: 10.1007/4-431-27174-0_20  0.496
2004 Minagawa M, Deng Q, Liu ZX, Tsukamoto H, Dennert G. Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology. 126: 1387-99. PMID 15131799 DOI: 10.1053/J.Gastro.2004.01.022  0.455
2004 Veal N, Hsieh CL, Xiong S, Mato JM, Lu S, Tsukamoto H. Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G352-62. PMID 15064230 DOI: 10.1152/Ajpgi.00316.2003  0.338
2004 Xiong S, She H, Tsukamoto H. Signaling role of iron in NF-kappa B activation in hepatic macrophages. Comparative Hepatology. 3: S36. PMID 14960188 DOI: 10.1186/1476-5926-2-S1-S36  0.359
2004 Hazra S, Miyahara T, Rippe RA, Tsukamoto H. PPAR Gamma and Hepatic Stellate Cells. Comparative Hepatology. 3: S7. PMID 14960159 DOI: 10.1186/1476-5926-2-S1-S7  0.721
2004 Hazra S, Xiong S, Wang J, Rippe RA, Krishna V, Chatterjee K, Tsukamoto H. Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. The Journal of Biological Chemistry. 279: 11392-401. PMID 14702344 DOI: 10.1074/Jbc.M310284200  0.726
2004 Sung CK, She H, Xiong S, Tsukamoto H. Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 286: G722-9. PMID 14656714 DOI: 10.1152/Ajpgi.00411.2003  0.372
2004 Han YP, Zhou L, Wang J, Xiong S, Garner WL, French SW, Tsukamoto H. Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen. The Journal of Biological Chemistry. 279: 4820-8. PMID 14617627 DOI: 10.1074/Jbc.M310999200  0.324
2004 Zhang AS, Xiong S, Tsukamoto H, Enns CA. Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood. 103: 1509-14. PMID 14563638 DOI: 10.1182/Blood-2003-07-2378  0.368
2003 Tao N, Sussman S, Nieto J, Tsukamoto H, Yuan JM. Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county. Alcoholism, Clinical and Experimental Research. 27: 1798-804. PMID 14634496 DOI: 10.1097/01.Alc.0000095862.30777.D9  0.371
2003 Xiong S, She H, Sung CK, Tsukamoto H. Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol (Fayetteville, N.Y.). 30: 107-13. PMID 12957294 DOI: 10.1016/S0741-8329(03)00100-9  0.434
2003 Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, Zandi E, Giulivi C, Tsukamoto H. Signaling role of intracellular iron in NF-kappaB activation. The Journal of Biological Chemistry. 278: 17646-54. PMID 12637578 DOI: 10.1074/Jbc.M210905200  0.303
2003 SANGHANI S, MELLO T, DAVIS W, TSUKAMOTO H, GALLI A, CASINI A, BOSRON W. 1296 Hormone sensitive lipase is a retinyl ester hydrolase in hepatic stellate cells Hepatology. 38: 783-783. DOI: 10.1016/S0270-9139(03)81334-4  0.38
2003 HAN Y, ZHOU L, WANG J, XIONG S, GARNER W, TSUKAMOTO H. 1283 Type I collagen and IL-1 serve as co-stimulatory signals for MMP-9 induction and hepatic stellate cell activation Hepatology. 38: 777-777. DOI: 10.1016/S0270-9139(03)81321-6  0.341
2003 SHE H, HAZRA S, XIONG S, WANG J, SUNG C, TSUKAMOTO H. 211 Adipogenic regulation of hepatic stellate cell transdifferentiation Hepatology. 38: 258-258. DOI: 10.1016/S0270-9139(03)80254-9  0.732
2002 Tsukamoto H. Redox regulation of cytokine expression in Kupffer cells. Antioxidants & Redox Signaling. 4: 741-8. PMID 12470501 DOI: 10.1089/152308602760598882  0.475
2002 Neuman MG, Katz GG, Malkiewicz IM, Mathurin P, Tsukamoto H, Adachi M, Ishii H, Colell A, García-Ruiz C, Fernández-Checa JC, Casey CA. Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001. Alcohol (Fayetteville, N.Y.). 28: 117-28. PMID 12457943 DOI: 10.1016/S0741-8329(02)00243-4  0.39
2002 She H, Xiong S, Lin M, Zandi E, Giulivi C, Tsukamoto H. Iron activates NF-kappaB in Kupffer cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 283: G719-26. PMID 12181188 DOI: 10.1152/Ajpgi.00108.2002  0.355
2002 Lu SC, Tsukamoto H, Mato JM. Role of abnormal methionine metabolism in alcoholic liver injury. Alcohol (Fayetteville, N.Y.). 27: 155-62. PMID 12163143 DOI: 10.1016/S0741-8329(02)00226-4  0.495
2002 Mathurin P, Xiong S, Kharbanda KK, Veal N, Miyahara T, Motomura K, Rippe RA, Bachem MG, Tsukamoto H. IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 282: G981-90. PMID 12016123 DOI: 10.1152/Ajpgi.00293.2001  0.31
2002 Tsukamoto H. Iron regulation of hepatic macrophage TNFalpha expression. Free Radical Biology & Medicine. 32: 309-13. PMID 11841920 DOI: 10.1016/S0891-5849(01)00772-9  0.4
2001 Motomura K, Ohata M, Satre M, Tsukamoto H. Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease. American Journal of Physiology. Endocrinology and Metabolism. 281: E420-9. PMID 11500296 DOI: 10.1152/Ajpendo.2001.281.3.E420  0.34
2001 Tsukamoto H, Lu SC. Current concepts in the pathogenesis of alcoholic liver injury The Faseb Journal. 15: 1335-1349. PMID 11387231 DOI: 10.1096/Fj.00-0650Rev  0.486
2001 Rose ML, Bradford BU, Germolec DR, Lin M, Tsukamoto H, Thurman RG. Gadolinium chloride-induced hepatocyte proliferation is prevented by antibodies to tumor necrosis factor alpha. Toxicology and Applied Pharmacology. 170: 39-45. PMID 11141354 DOI: 10.1006/Taap.2000.9077  0.356
2001 Crabb DW, Pinairs J, Hasanadka R, Fang M, Leo MA, Lieber CS, Tsukamoto H, Motomura K, Miyahara T, Ohata M, Bosron W, Sanghani S, Kedishvili N, Shiraishi H, Yokoyama H, et al. Alcohol and Retinoids Alcoholism: Clinical and Experimental Research. 25: 207S-217S. DOI: 10.1111/J.1530-0277.2001.Tb02398.X  0.332
2001 Tsukamoto H, Takei Y, McClain CJ, Joshi‐Barve S, Hill D, Schmidt J, Deaciuc I, Barve S, Colell A, Garcia‐Ruiz C, Kaplowitz N, Fernandez‐Checa JC, Yokoyama H, Okamura Y, Nakamura Y, et al. How is the liver primed or sensitized for alcoholic liver disease Alcoholism: Clinical and Experimental Research. 25. DOI: 10.1111/J.1530-0277.2001.Tb02393.X  0.461
2000 Lang A, Schrum LW, Schoonhoven R, Tuvia S, Solís-Herruzo JA, Tsukamoto H, Brenner DA, Rippe RA. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. American Journal of Physiology. Gastrointestinal and Liver Physiology. 279: G1333-42. PMID 11093957 DOI: 10.1152/Ajpgi.2000.279.6.G1333  0.377
2000 Mathurin P, Deng QG, Keshavarzian A, Choudhary S, Holmes EW, Tsukamoto H. Exacerbation of alcoholic liver injury by enteral endotoxin in rats Hepatology. 32: 1008-1017. PMID 11050051 DOI: 10.1053/Jhep.2000.19621  0.411
2000 Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF, Motomura K, Anania FA, Willson TM, Tsukamoto H. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. The Journal of Biological Chemistry. 275: 35715-22. PMID 10969082 DOI: 10.1074/Jbc.M006577200  0.467
2000 Lu SC, Huang ZZ, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. American Journal of Physiology. Gastrointestinal and Liver Physiology. 279: G178-85. PMID 10898761 DOI: 10.1152/Ajpgi.2000.279.1.G178  0.478
2000 Ohata M, Yamauchi M, Takeda K, Toda G, Kamimura S, Motomura K, Xiong S, Tsukamoto H. RAR and RXR Expression by Kupffer Cells Experimental and Molecular Pathology. 68: 13-20. PMID 10640450 DOI: 10.1006/Exmp.1999.2284  0.37
2000 Tsukamoto H, Lin M, Ohata M, Giulivi C, French SW, Brittenham G. Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury. The American Journal of Physiology. 277: G1240-50. PMID 10600822 DOI: 10.1152/Ajpgi.1999.277.6.G1240  0.405
1999 Lu SC, Huang Z, Yang H, Tsukamoto H. Effect of Thioacetamide on the Hepatic Expression of γ-Glutamylcysteine Synthetase Subunits in the Rat Toxicology and Applied Pharmacology. 159: 161-168. PMID 10486302 DOI: 10.1006/Taap.1999.8729  0.36
1999 Pandol SJ, Periskic S, Gukovsky I, Zaninovic V, Jung Y, Zong Y, Solomon TE, Gukovskaya AS, Tsukamoto H. Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide. Gastroenterology. 117: 706-16. PMID 10464148 DOI: 10.1016/S0016-5085(99)70465-8  0.329
1999 Lu SC, Huang Z, Yang JM, Tsukamoto H. Effect of ethanol and high-fat feeding on hepatic γ-glutamylcysteine synthetase subunit expression in the rat Hepatology. 30: 209-214. PMID 10385658 DOI: 10.1002/Hep.510300134  0.387
1999 Tsukamoto H. Cytokine Regulation of Hepatic Stellate Cells in Liver Fibrosis Alcoholism: Clinical and Experimental Research. 23: 911-916. DOI: 10.1111/J.1530-0277.1999.Tb04202.X  0.426
1998 Tsukamoto H. Is interleukin-10 antifibrogenic in chronic liver injury? Hepatology. 28: 1707-1709. PMID 9828239 DOI: 10.1002/Hep.510280635  0.364
1998 Tsukamoto H. Molecular Mechanism of Induced Hepatic Macrophage Cytokine Gene Expression in Experimental Alcoholic Liver Injury Alcoholism: Clinical and Experimental Research. 22. PMID 9727646 DOI: 10.1111/J.1530-0277.1998.Tb04012.X  0.467
1998 Rusyn I, Tsukamoto H, Thurman RG. WY-14 643 rapidly activates nuclear factor κB in Kupffer cells before hepatocytes Carcinogenesis. 19: 1217-1222. PMID 9683180 DOI: 10.1093/Carcin/19.7.1217  0.403
1998 Wang SC, Ohata M, Schrum L, Rippe RA, Tsukamoto H. Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. The Journal of Biological Chemistry. 273: 302-8. PMID 9417080 DOI: 10.1074/Jbc.273.1.302  0.388
1998 Tsukamoto H. MOLECULAR BASIS FOR THE ROLE OF IRON IN EXPERIMENTAL ALCOHOLIC LIVER INJURY Alcoholism: Clinical and Experimental Research. 22: 756-757. DOI: 10.1111/J.1530-0277.1998.Tb04334.X  0.491
1997 Lin M, Rippe RA, Niemela O, Brittenham G, Tsukamoto H. Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages American Journal of Physiology-Gastrointestinal and Liver Physiology. 272. PMID 9227470 DOI: 10.1152/Ajpgi.1997.272.6.G1355  0.377
1997 Ohata M, Lin M, Satre M, Tsukamoto H. Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis American Journal of Physiology-Gastrointestinal and Liver Physiology. 272. PMID 9124579 DOI: 10.1152/Ajpgi.1997.272.3.G589  0.466
1996 Tsukamoto H, Cheng S, Blaner WS. Effects of dietary polyunsaturated fat on ethanol-induced Ito cell activation. American Journal of Physiology-Gastrointestinal and Liver Physiology. 270. PMID 8928787 DOI: 10.1152/Ajpgi.1996.270.4.G581  0.407
1996 Hellerbrand C, Wang SC, Tsukamoto H, Brenner DA, Rippe RA. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology. 24: 670-676. PMID 8781341 DOI: 10.1002/Hep.510240333  0.463
1996 Tandler B, Horne WI, Brittenham GM, Tsukamoto H. Giant mitochondria induced in rat pancreatic exocrine cells by ethanol and iron. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology. 245: 65-75. PMID 8731042 DOI: 10.1002/(Sici)1097-0185(199605)245:1<65::Aid-Ar11>3.0.Co;2-7  0.313
1995 Tsukamoto H, Rippe R, Niemelä O, Lin M. Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis Journal of Gastroenterology and Hepatology. 10. PMID 8589343 DOI: 10.1111/J.1440-1746.1995.Tb01798.X  0.472
1995 Tsukamoto H, Horne W, Kamimura S, Niemelä O, Parkkila S, Ylä-Herttuala S, Brittenham GM. Experimental liver cirrhosis induced by alcohol and iron. Journal of Clinical Investigation. 96: 620-630. PMID 7615836 DOI: 10.1172/Jci118077  0.457
1995 Kamimura S, Tsukamoto H. Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease Hepatology. 22: 1304-1309. DOI: 10.1002/Hep.1840220441  0.463
1993 Horne WI, Tsukamoto H. Dietary modulation of alcohol-induced pancreatic injury. Alcohol. 10: 481-484. PMID 8123204 DOI: 10.1016/0741-8329(93)90069-Z  0.348
1993 Fernández-Checa J, Hirano T, Tsukamoto H, Kaplowitz N. Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol. 10: 469-475. PMID 8123202 DOI: 10.1016/0741-8329(93)90067-X  0.39
1993 Tsukamoto H. Oxidative stress, antioxidants, and alcoholic liver fibrogenesis Alcohol. 10: 465-467. PMID 8123201 DOI: 10.1016/0741-8329(93)90066-W  0.526
1993 Tsukamoto H, French SW. Introduction: Evolution of intragastric ethanol infusion model Alcohol. 10: 439-441. DOI: 10.1016/0741-8329(93)90061-R  0.374
1992 Smith SM, Tokuda S, Tsukamoto H. Mucosal immune dysfunction associated with alcoholic IgA nephropathy Clinical Immunology and Immunopathology. 64: 205-209. PMID 1643753 DOI: 10.1016/0090-1229(92)90201-X  0.36
1992 Kamimura S, Gaal K, Britton RS, Bacon BR, Triadafilopoulos G, Tsukamoto H. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis. Hepatology. 16: 448-453. PMID 1639354 DOI: 10.1002/Hep.1840160225  0.483
1992 Smith SM, Tsukamoto H. Time dependency of IgA nephropathy induction in alcohol ingestion Alcoholism: Clinical and Experimental Research. 16: 471-473. PMID 1626647 DOI: 10.1111/J.1530-0277.1992.Tb01402.X  0.348
1992 Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology (Baltimore, Md.). 16: 1423-7. PMID 1446896 DOI: 10.1002/Hep.1840160619  0.443
1992 Castillo T, Koop DR, Kamimura S, Triadafilopoulos G, Tsukamoto H. Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation. Hepatology (Baltimore, Md.). 16: 992-6. PMID 1398507 DOI: 10.1002/Hep.1840160423  0.343
1990 Matsuoka M, Tsukamoto H. Stimulation of hepatic lipocyte collagen production by Kupffer cell‐derived transforming growth factor β: Implication for a pathogenetic role in alcoholic liver fibrogenesis Hepatology. 11: 599-605. PMID 2328954 DOI: 10.1002/Hep.1840110412  0.484
1990 Matsuoka M, Zhang MY, Tsukamoto H. Sensitization of hepatic lipocytes by high-fat diet to stimulatory effects of Kupffer cell-derived factors: Implication in alcoholic liver fibrogenesis Hepatology. 11: 173-182. PMID 2307396 DOI: 10.1002/Hep.1840110204  0.376
1990 Tsukamoto H, Gaal K, French SW. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: Status report Hepatology. 12: 599-608. PMID 2205558 DOI: 10.1002/Hep.1840120325  0.505
1990 Tsukamoto H, Matsuoka M, French SW. Experimental models of hepatic fibrosis: A review Seminars in Liver Disease. 10: 56-65. PMID 2110685 DOI: 10.1055/S-2008-1040457  0.431
1990 MATSUOKA M, TSUKAMOTO H. Expression of TGF?1 by Rat Kupffer Cells: Implication for a Pathogenetic Role in Alcoholic Liver Fibrosis Annals of the New York Academy of Sciences. 593: 357-359. DOI: 10.1111/J.1749-6632.1990.Tb16144.X  0.483
1989 Tsukamoto H, Xi XP. Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis. Hepatology. 9: 302-306. PMID 2912830 DOI: 10.1002/Hep.1840090223  0.43
1989 Nanji AA, Tsukamoto H, French SW. Relationship between fatty liver and subsequent development of necrosis, inflammation and fibrosis in experimental alcoholic liver disease Experimental and Molecular Pathology. 51: 141-148. PMID 2806468 DOI: 10.1016/0014-4800(89)90014-2  0.438
1989 Matsuoka M, Pham NT, Tsukamoto H. Differential effects of interleukin-1 alpha, tumor necrosis factor alpha, and transforming growth factor beta 1 on cell proliferation and collagen formation by cultured fat-storing cells. Liver. 9: 71-8. PMID 2785237 DOI: 10.1111/J.1600-0676.1989.Tb00382.X  0.331
1988 Peppin JF, Towner SJ, Matsuoka M, Kawasaki RI, Ananda Rao G, Tsukamoto H. Effects of sustained ethanol intoxication and optimal nutrition on free amino acid levels in plasma, liver and muscle of the rat Nutrition Research. 8: 65-71. DOI: 10.1016/S0271-5317(88)80088-5  0.345
1987 Inomata T, Rao GA, Tsukamoto H. Lack of evidence for increased lipid peroxidation in ethanol-induced centrilobular necrosis of rat liver Liver. 7: 233-239. PMID 3683096 DOI: 10.1111/J.1600-0676.1987.Tb00349.X  0.423
1986 Tsukamoto H, Sankaran H, Delgado G, Reidelberger RD, Deveney CW, Largman C. Increased pancreatic acinar content and secretion of cationic trypsinogen following 30-day continuous ethanol intoxication in rats Biochemical Pharmacology. 35: 3623-3629. PMID 3768045 DOI: 10.1016/0006-2952(86)90635-0  0.361
1986 Tsukamoto H, Towner SJ, Ciofalo LM, French SW. Ethanol-induced liver fibrosis in rats fed high fat diet Hepatology. 6: 814-822. PMID 3758935 DOI: 10.1002/Hep.1840060503  0.465
1986 French SW, Miyamoto K, Tsukamoto H. Ethanol-induced hepatic fibrosis in the rat: Role of the amount of dietary fat Alcoholism: Clinical and Experimental Research. 10: 13-19. PMID 3544925 DOI: 10.1111/J.1530-0277.1986.Tb05175.X  0.336
1985 Tsukamoto H, French SW, Benson N, Delgado G, Rao GA, Larkin EC, Largman C. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet Hepatology. 5: 224-232. PMID 3979954 DOI: 10.1002/Hep.1840050212  0.428
1985 Tsukamoto H, French SW, Rektelberger RD, Largman C. Cyclical Pattern of Blood Alcohol Levels during Continuous Intragastric Ethanol Infusion in Rats Alcoholism: Clinical and Experimental Research. 9: 31-37. PMID 3887966 DOI: 10.1111/J.1530-0277.1985.Tb05046.X  0.338
1985 Tsukamoto H, Kiefer MA, Ananda Rao G, Larkin EC, Largman C, Sankaran H. Cholecystokinin-induced secretion and synthesis of amylase and cationic trypsinogen by pancreatic acini isolated from rats given an ethanol diet Life Sciences. 37: 1359-1365. PMID 2413328 DOI: 10.1016/0024-3205(85)90073-6  0.352
1984 Tsukamoto H, Lew G, Larkin EC, Largman C, Rao GA. Hepatic origin of triglycerides in fatty livers produced by the continuous intragastric infusion of an ethanol diet. Lipids. 19: 419-22. PMID 6738318 DOI: 10.1007/Bf02537403  0.414
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