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Meghali P. Nighot, Ph.D. - Publications

Affiliations: 
2012 North Carolina State University, Raleigh, NC 
Area:
Molecular Biology
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Saha K, Subramenium Ganapathy A, Wang A, Arumugam P, Michael Morris N, Harris L, Yochum G, Koltun W, Perdew GH, Nighot M, Ma T, Nighot P. Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation. Mucosal Immunology. PMID 37716509 DOI: 10.1016/j.mucimm.2023.09.003  0.643
2023 Ganapathy AS, Saha K, Wang A, Arumugam P, Dharmaprakash V, Yochum G, Koltun W, Nighot M, Perdew G, Thompson TA, Ma T, Nighot P. Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways. Cell Reports. 42: 112705. PMID 37393618 DOI: 10.1016/j.celrep.2023.112705  0.707
2022 Nighot M, Liao PL, Morris N, Mccarthy D, Dharmaprakash V, Khan IU, Dalessio S, Saha K, Ganapathy AS, Wang A, Ding W, Yochum G, Koltun W, Nighot P, Ma T. Long term use of Proton Pump Inhibitor disrupts intestinal tight junction barrier and exaggerates experimental colitis. Journal of Crohn's & Colitis. PMID 36322638 DOI: 10.1093/ecco-jcc/jjac168  0.682
2022 Saha K, Ganapathy AS, Wang A, Morris NM, Suchanec E, Ding W, Yochum G, Koltun W, Nighot M, Ma T, Nighot P. Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal Epithelial Tight Junction Barrier against Paracellular Macromolecule Flux. Journal of Crohn's & Colitis. PMID 36219473 DOI: 10.1093/ecco-jcc/jjac148  0.684
2021 Ganapathy AS, Saha K, Suchanec E, Singh V, Verma A, Yochum G, Koltun W, Nighot M, Ma T, Nighot P. AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability. Autophagy. 1-18. PMID 34964704 DOI: 10.1080/15548627.2021.2016233  0.674
2021 Al-Sadi R, Dharmaprakash V, Nighot P, Guo S, Nighot M, Do T, Ma TY. Enhances the Intestinal Epithelial Tight Junction Barrier and Protects against Intestinal Inflammation by Targeting the Toll-like Receptor-2 Pathway in an NF-κB-Independent Manner. International Journal of Molecular Sciences. 22. PMID 34360835 DOI: 10.3390/ijms22158070  0.719
2021 Nighot M, Ganapathy AS, Saha K, Suchanec E, Castillo E, Gregory A, Shapiro S, Ma T, Nighot P. Matrix Metalloproteinase MMP-12 promotes macrophage transmigration across intestinal epithelial tight junctions and increases severity of experimental colitis. Journal of Crohn's & Colitis. PMID 33836047 DOI: 10.1093/ecco-jcc/jjab064  0.629
2021 Al-Sadi R, Nighot P, Nighot M, Haque M, Rawat M, Ma TY. Lactobacillus acidophilus induces a strain-specific and toll-like receptor-2 dependent enhancement of intestinal epithelial tight junction barrier and protection against intestinal inflammation. The American Journal of Pathology. PMID 33607043 DOI: 10.1016/j.ajpath.2021.02.003  0.697
2020 Rawat M, Nighot M, Al-Sadi R, Gupta Y, Viszwapriya D, Yochum G, Koltun W, Ma TY. IL1B Increases Intestinal Tight Junction Permeability by Upregulation of MIR200C-3p, Which Degrades Occludin mRNA. Gastroenterology. PMID 32569770 DOI: 10.1053/J.Gastro.2020.06.038  0.385
2020 Ganapathy AS, Suchanec E, Saha K, Nighot M, Ma TY, Nighot PK. Su1104 ALPHA-TOCOPHERYLQUINONE ACTIVATES ARYL HYDROCARBON RECEPTOR AND ENHANCES INTESTINAL EPITHELIAL TIGHT JUNCTION BARRIER FUNCTION Gastroenterology. 158: S-510. DOI: 10.1016/S0016-5085(20)31956-9  0.667
2020 Al-Sadi R, dharmaprakash V, Rawat M, Nighot M, Haque M, Engers J, Ma TY. Sa1140 MMP-9 DISRUPTION OF INTESTINAL EPITHELIAL TIGHT JUNCTION BARRIER IS MEDIATED BY MICRO-RNA 122A DOWN-REGULATION OF OCCLUDIN Gastroenterology. 158: S-289. DOI: 10.1016/S0016-5085(20)31414-1  0.343
2020 Haque M, Al-Sadi R, Nighot M, dharmaprakash V, Ma TY. 471 PROBIOTIC ENHANCEMENT OF INTESTINAL EPITHELIAL BARRIER AND PROTECTION AGAINST PROINFLAMMATORY MEDIATOR- INDUCED INCREASE IN MOUSE INTESTINAL PERMEABILITY IN-VIVO. Gastroenterology. 158: S-90. DOI: 10.1016/S0016-5085(20)30907-0  0.525
2019 Nighot M, Rawat M, Sadi RA, Castillo EF, Nighot P, Ma T. Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene. The American Journal of Pathology. PMID 30711488 DOI: 10.1016/j.ajpath.2018.12.016  0.671
2019 Al-Sadi R, Nighot P, Nighot M, Guo S, Ma TY. P123 LACTOBACILLUS ACIDOPHILUS MODULATION OF MOUSE INTESTINAL TIGHT JUNCTION BARRIER: ROLE OF TOLL-LIKE RECEPTOR-2 (TLR-2) Gastroenterology. 156: S86. DOI: 10.1053/J.Gastro.2019.01.199  0.677
2019 Al-Sadi R, Nighot P, Nighot M, Guo S, Ma TY. Su1829 – Lactobacillus Acidophilus Causes an Enhancement of Intestinal Epithelial Tight Junction Barrier and Protects Against Dss-Induced Colitis Gastroenterology. 156: S-627. DOI: 10.1016/S0016-5085(19)38466-5  0.723
2019 Nighot MP, Castillo EF, Rawat M, Dokladny K, Al-Sadi R, Nighot P, Ma TY. 697 – Intestinal Permeability is an Important Factor in the Development of Alcoholic Liver Disease in a Chronic and Binge Mouse Model of Alcoholic Steatohepatitis Gastroenterology. 156: S-152-S-153. DOI: 10.1016/S0016-5085(19)37171-9  0.606
2018 Nighot M, Nighot P. Pathophysiology of avian intestinal ion transport. World's Poultry Science Journal. 74: 347-360. PMID 29805185 DOI: 10.1017/S004393391800003X  0.683
2018 Nighot MP, Ma TY. 140 - Chronic Proton Pump Inhibitors (PPI) Administration Causes an Increase in Colonic Permeability and Exacerbates Experimental Colitis in Mice Gastroenterology. 154: S-38. DOI: 10.1016/S0016-5085(18)30598-5  0.316
2017 Nighot M, Al-Sadi R, Guo S, Rawat M, Nighot P, Watterson MD, Ma TY. Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression. The American Journal of Pathology. 187: 2698-2710. PMID 29157665 DOI: 10.1016/J.Ajpath.2017.08.005  0.706
2017 Nighot MP, Mccarthy DM, Ma TY. Proton Pump Inhibitors (PPI) Induces Increase in Gastric Epithelial Tight Junction Permeability Via Activation of Myosin Light-Chain Kinase Gastroenterology. 152: S888. DOI: 10.1016/S0016-5085(17)33035-4  0.355
2016 Nighot MP, Ma TY. Tu1841 Lipopolysaccharide-Induced Increase in Intestinal Permeability is Mediated by p38 MAPK Activation of Canonical NFkB Pathway Gastroenterology. 150: S958. DOI: 10.1016/S0016-5085(16)33235-8  0.419
2016 Nighot MP, Guo S, Al-Sadi R, Ma TY. 1094 Myosin Light-Chain Kinase Mediates the Lipopolysaccharide-Induced Increase in Intestinal Permeability Gastroenterology. 150: S218-S219. DOI: 10.1016/S0016-5085(16)30809-5  0.361
2016 Rawat M, Al-Sadi R, Nighot MP, Ma TY. 617 Molecular Mechanism of microRNA Regulation of IL-1β Induced Increase in Intestinal Tight Junction Permeability Gastroenterology. 150: S126-S127. DOI: 10.1016/S0016-5085(16)30531-5  0.357
2015 Guo S, Nighot M, Al-Sadi R, Alhmoud T, Nighot P, Ma TY. Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88. Journal of Immunology (Baltimore, Md. : 1950). PMID 26466961 DOI: 10.4049/Jimmunol.1402598  0.699
2015 Nighot MP, Nighot PK, Ma TY, Malinowska DH, Shull GE, Cuppoletti J, Blikslager AT. Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion. Plos One. 10: e0138174. PMID 26378782 DOI: 10.1371/Journal.Pone.0138174  0.711
2014 Nighot MP, Nighot PK, Ma TY, Blikslager A. Su1947 Genetic Absence of Chloride Channel CLC-2 Results in Disruption of Organization and Function of Murine Gastric Glands Gastroenterology. 146: S-505-S-506. DOI: 10.1016/S0016-5085(14)61827-8  0.697
2013 Nighot P, Young K, Nighot M, Rawat M, Sung EJ, Maharshak N, Plevy SE, Ma T, Blikslager A. Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis. Inflammatory Bowel Diseases. 19: 2867-77. PMID 24030525 DOI: 10.1097/Mib.0B013E3182A82Ae9  0.732
2013 Nighot MP, Nighot PK, Young K, Edwards L, Blikslager A, Moeser AJ. Tu1641 Effects of Lubiprostone in a Porcine Model of Stress-Induced Intestinal Barrier Injury Gastroenterology. 144: S-812-S-813. DOI: 10.1016/S0016-5085(13)63010-3  0.748
2012 Nighot M, Moeser A, Ueno R, Blikslager A. Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa. World Journal of Gastroenterology. 18: 4684-92. PMID 23002337 DOI: 10.3748/Wjg.V18.I34.4684  0.695
2012 Nighot MP, Ueno R, Blikslager A. Su1751 The CLC-2 Agonist SPI-0811 Protects Against Indomethacin-Induced Epithelial Barrier Dysfunction in Human Gastric Epithelial Cells Gastroenterology. 142: S-495. DOI: 10.1016/S0016-5085(12)61893-9  0.626
2011 Nighot MP, Blikslager A. Indomethacin Induces Gastric Epithelial Barrier Dysfunction via a p38 MAPK-Dependent Mechanism in MKN-28 Cells Gastroenterology. 140: S-315. DOI: 10.1016/S0016-5085(11)61271-7  0.528
2011 Nighot MP, Blikslager A, Nighot PK. The Chloride Channel CLC-2 is Involved in Organization of Murine Gastric Glands Gastroenterology. 140: S-93. DOI: 10.1016/S0016-5085(11)60379-X  0.704
2008 Nighot MP, Ueno R, Roerig B, Ryan KA, Blikslager AT, Moeser AJ. W1738 Gastroprotective Properties of Cobiprostone Against Acid and NSAID-Induced Mucosal Injury in Porcine Gastric Mucosa Gastroenterology. 134: A-705. DOI: 10.1016/S0016-5085(08)63293-X  0.711
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