Year |
Citation |
Score |
2023 |
Frame AK, Robinson JW, Mahmoudzadeh NH, Tennessen JM, Simon AF, Cumming RC. Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies. Aging. 15: 947-981. PMID 36849157 DOI: 10.18632/aging.204565 |
0.727 |
|
2022 |
Frame AK, Cumming RC. Using the urea cycle to shift astrocytes from harmful to helpful in Alzheimer's disease. Cell Metabolism. 34: 1079-1081. PMID 35921813 DOI: 10.1016/j.cmet.2022.07.001 |
0.69 |
|
2020 |
Yost RT, Robinson JW, Baxter CM, Scott AM, Brown LP, Aletta MS, Hakimjavadi R, Lone A, Cumming RC, Dukas R, Mozer B, Simon AF. Abnormal Social Interactions in a Mutant of an Autism Candidate Gene: . International Journal of Molecular Sciences. 21. PMID 32610435 DOI: 10.3390/Ijms21134601 |
0.535 |
|
2020 |
Long DM, Frame AK, Reardon PN, Cumming RC, Hendrix DA, Kretzschmar D, Giebultowicz JM. Lactate dehydrogenase expression modulates longevity and neurodegeneration in . Aging. 12. PMID 32484787 DOI: 10.18632/aging.103373 |
0.723 |
|
2020 |
Kozlov AM, Lone A, Betts DH, Cumming RC. Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts. Scientific Reports. 10: 8388. PMID 32433492 DOI: 10.1038/S41598-020-65193-9 |
0.327 |
|
2020 |
Frame AK, Simon AF, Cumming RC. Determining the role of lactate metabolism on age‐dependent memory decline and neurodegeneration in
Drosophila melanogaster Alzheimer's & Dementia. 16. DOI: 10.1002/alz.037313 |
0.325 |
|
2019 |
Frame AK, Lone A, Harris RA, Cumming RC. Simple Protocol for Distinguishing Drug-induced Effects on Spatial Memory Acquisition, Consolidation and Retrieval in Mice Using the Morris Water Maze. Bio-Protocol. 9: e3376. PMID 33654872 DOI: 10.21769/BioProtoc.3376 |
0.694 |
|
2019 |
Harris RA, Lone A, Lim H, Martinez F, Frame AK, Scholl TJ, Cumming RC. Aerobic Glycolysis Is Required for Spatial Memory Acquisition But Not Memory Retrieval in Mice. Eneuro. 6. PMID 30809587 DOI: 10.1523/ENEURO.0389-18.2019 |
0.72 |
|
2018 |
Lone A, Harris RA, Singh O, Betts DH, Cumming RC. p66Shc activation promotes increased oxidative phosphorylation and renders CNS cells more vulnerable to amyloid beta toxicity. Scientific Reports. 8: 17081. PMID 30459314 DOI: 10.1038/S41598-018-35114-Y |
0.392 |
|
2018 |
Harris RA, Lone A, Lim H, Scholl TJ, Cumming RC. P2-148: Aerobic Glycolysis Is Required For Spatial Memory Consolidation But Not Memory Retrieval In Mice Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.834 |
0.402 |
|
2016 |
Harris RA, Tindale L, Lone A, Singh O, Macauley SL, Stanley M, Holtzman DM, Bartha R, Cumming RC. Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1871-8. PMID 26865611 DOI: 10.1523/Jneurosci.3131-15.2016 |
0.441 |
|
2016 |
Lone A, Cumming RC. P66SHC EXPRESSION AFFECTS THE METABOLIC STATE AND AMYLOID-β SENSITIVITY IN NEURONAL CELLS Alzheimers & Dementia. 12: 462. DOI: 10.1016/J.Jalz.2016.06.902 |
0.343 |
|
2014 |
Harris RA, Tindale L, Cumming RC. Age-dependent metabolic dysregulation in cancer and Alzheimer's disease. Biogerontology. 15: 559-77. PMID 25305052 DOI: 10.1007/S10522-014-9534-Z |
0.382 |
|
2013 |
Newington JT, Harris RA, Cumming RC. Reevaluating Metabolism in Alzheimer's Disease from the Perspective of the Astrocyte-Neuron Lactate Shuttle Model. Journal of Neurodegenerative Diseases. 2013: 234572. PMID 26316984 DOI: 10.1155/2013/234572 |
0.304 |
|
2013 |
Arseneault R, Chien A, Newington JT, Rappon T, Harris R, Cumming RC. Attenuation of LDHA expression in cancer cells leads to redox-dependent alterations in cytoskeletal structure and cell migration. Cancer Letters. 338: 255-66. PMID 23583676 DOI: 10.1016/J.Canlet.2013.03.034 |
0.316 |
|
2012 |
Newington JT, Rappon T, Albers S, Wong DY, Rylett RJ, Cumming RC. Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production Journal of Biological Chemistry. 287: 37245-37258. PMID 22948140 DOI: 10.1074/Jbc.M112.366195 |
0.327 |
|
2012 |
Pitts A, Dailey K, Newington JT, Chien A, Arseneault R, Cann T, Thompson LM, Cumming RC. Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin. The Journal of Biological Chemistry. 287: 22717-29. PMID 22577145 DOI: 10.1074/Jbc.M111.334565 |
0.322 |
|
2011 |
Newington JT, Pitts A, Chien A, Arseneault R, Schubert D, Cumming RC. Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect. Plos One. 6: e19191. PMID 21541279 DOI: 10.1371/Journal.Pone.0019191 |
0.348 |
|
2011 |
Bartlett BJ, Isakson P, Lewerenz J, Sanchez H, Kotzebue RW, Cumming RC, Harris GL, Nezis IP, Schubert DR, Simonsen A, Finley KD. p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy. 7: 572-83. PMID 21325881 DOI: 10.4161/Auto.7.6.14943 |
0.348 |
|
2009 |
Schubert D, Herrera F, Cumming R, Read J, Low W, Maher P, Fischer WH. Neural cells secrete a unique repertoire of proteins. Journal of Neurochemistry. 109: 427-35. PMID 19200335 DOI: 10.1111/J.1471-4159.2009.05968.X |
0.316 |
|
2008 |
Cumming RC, Simonsen A, Finley KD. Quantitative analysis of autophagic activity in Drosophila neural tissues by measuring the turnover rates of pathway substrates. Methods in Enzymology. 451: 639-51. PMID 19185743 DOI: 10.1016/S0076-6879(08)03235-7 |
0.375 |
|
2008 |
Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy. 4: 176-84. PMID 18059160 DOI: 10.4161/Auto.5269 |
0.399 |
|
2007 |
Cumming RC, Dargusch R, Fischer WH, Schubert D. Increase in expression levels and resistance to sulfhydryl oxidation of peroxiredoxin isoforms in amyloid beta-resistant nerve cells. The Journal of Biological Chemistry. 282: 30523-34. PMID 17761673 DOI: 10.1074/Jbc.M700869200 |
0.33 |
|
2007 |
Simonsen A, Cumming RC, Finley KD. Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila. Autophagy. 3: 499-501. PMID 17617737 DOI: 10.4161/Auto.4604 |
0.304 |
|
2007 |
Simonsen A, Cumming RC, Lindmo K, Galaviz V, Cheng S, Rusten TE, Finley KD. Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. Genetics. 176: 1283-97. PMID 17435236 DOI: 10.1534/Genetics.106.065011 |
0.314 |
|
2003 |
Soucek T, Cumming R, Dargusch R, Maher P, Schubert D. The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron. 39: 43-56. PMID 12848931 DOI: 10.1016/S0896-6273(03)00367-2 |
0.339 |
|
2003 |
Finley KD, Edeen PT, Cumming RC, Mardahl-Dumesnil MD, Taylor BJ, Rodriguez MH, Hwang CE, Benedetti M, McKeown M. blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1254-64. PMID 12598614 DOI: 10.1523/Jneurosci.23-04-01254.2003 |
0.323 |
|
2001 |
Cumming RC, Lightfoot J, Beard K, Youssoufian H, O'Brien PJ, Buchwald M. Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1. Nature Medicine. 7: 814-20. PMID 11433346 DOI: 10.1038/89937 |
0.574 |
|
2001 |
Cumming RC, Buchwald M. Reply to ‘Cellular function of the Fanconi anemia pathway’ Nature Medicine. 7: 1259-1260. DOI: 10.1038/Nm1201-1259B |
0.5 |
|
1996 |
Cumming RC, Liu JM, Youssoufian H, Buchwald M. Suppression of apoptosis in hematopoietic factor-dependent progenitor cell lines by expression of the FAC gene. Blood. 88: 4558-67. PMID 8977247 DOI: 10.1182/Blood.V88.12.4558.Bloodjournal88124558 |
0.558 |
|
1995 |
Brady G, Billia F, Knox J, Hoang T, Kirsch IR, Voura EB, Hawley RG, Cumming R, Buchwald M, Siminovitch K. Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells. Current Biology : Cb. 5: 909-22. PMID 7583149 DOI: 10.1016/S0960-9822(95)00181-3 |
0.558 |
|
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