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John R. Vane, Ph.D. - Publications

Affiliations: 
Wellcome Foundation 
Area:
Platelets, prostaglandins
Website:
http://www.nobelprize.org/nobel_prizes/medicine/laureates/1982/vane-bio.html

177 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2003 Vane JR, Botting RM. The mechanism of action of aspirin. Thrombosis Research. 110: 255-258. PMID 14592543 DOI: 10.1016/S0049-3848(03)00379-7  0.345
2002 Vane JR. Biomedicine. Back to an aspirin a day? Science (New York, N.Y.). 296: 474-5. PMID 11964462 DOI: 10.1126/Science.1071702  0.313
1999 Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis Proceedings of the National Academy of Sciences of the United States of America. 96: 7563-7568. PMID 10377455 DOI: 10.1073/Pnas.96.13.7563  0.313
1999 Simmons DL, Botting RM, Robertson PM, Madsen ML, Vane JR. Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs. Proceedings of the National Academy of Sciences of the United States of America. 96: 3275-80. PMID 10077674 DOI: 10.1073/Pnas.96.6.3275  0.353
1998 Vane JR, Bakhle YS, Botting RM. Cyclooxygenases 1 And 2 Annual Review of Pharmacology and Toxicology. 38: 97-120. PMID 9597150 DOI: 10.1146/Annurev.Pharmtox.38.1.97  0.318
1997 Thiemermann C, Bowes J, Myint FP, Vane JR. Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle Proceedings of the National Academy of Sciences of the United States of America. 94: 679-683. PMID 9012844 DOI: 10.1073/Pnas.94.2.679  0.301
1997 Higgs EA, Higgs GA, Moncada S, Vane JR. Prostacyclin (Pgi2) Inhibits The Formation Of Platelet Thrombi In Arterioles And Venules Of The Hamster Cheek Pouch British Journal of Pharmacology. 63: 535-539. PMID 352466 DOI: 10.1111/J.1476-5381.1978.Tb07809.X  0.42
1996 Ruetten H, Thiemermann C, Vane JR. Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat. British Journal of Pharmacology. 118: 198-204. PMID 8733596 DOI: 10.1111/J.1476-5381.1996.Tb15386.X  0.319
1995 Hohlfeld T, Klemm P, Thiemermann C, Warner TD, Schror K, Vane JR. The contribution of tumour necrosis factor-α and endothelin-1 to the increase of coronary resistance in hearts from rats treated with endotoxin British Journal of Pharmacology. 116: 3309-3315. PMID 8719812 DOI: 10.1111/J.1476-5381.1995.Tb15140.X  0.34
1995 Kimpe SJD, Thiemermann C, Vane JR. Role for intracellular platelet-activating factor in the circulatory failure in a model of Gram-positive shock British Journal of Pharmacology. 116: 3191-3198. PMID 8719795 DOI: 10.1111/J.1476-5381.1995.Tb15123.X  0.397
1995 Thiemermann C, Ruetten H, Wu C, Vane JR. The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase British Journal of Pharmacology. 116: 2845-2851. PMID 8680715 DOI: 10.1111/J.1476-5381.1995.Tb15935.X  0.353
1995 Allcock GH, Warner TD, Vane JR. Roles of endothelin receptors in the regional and systemic vascular responses to ET‐1 in the anaesthetized ganglion‐blocked rat: use of selective antagonists British Journal of Pharmacology. 116: 2482-2486. PMID 8581288 DOI: 10.1111/J.1476-5381.1995.Tb15099.X  0.316
1995 Vane JR, Botting RM. Pharmacodynamic profile of prostacyclin American Journal of Cardiology. 75. PMID 7840052 DOI: 10.1016/S0002-9149(99)80377-4  0.376
1995 Klemm P, Warner TD, Hohlfeld T, Corder R, Vane JR. Endothelin 1 mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines Proceedings of the National Academy of Sciences of the United States of America. 92: 2691-2695. PMID 7708707 DOI: 10.1073/Pnas.92.7.2691  0.311
1995 Klemm P, Warner TD, Willis D, Moore AR, Vane JR. Coronary vasoconstriction in vitro in the hearts of polyarthritic rats: effectiveness of in vivo treatment with the endothelin receptor antagonist SB 209670. British Journal of Pharmacology. 114: 1327-8. PMID 7606336 DOI: 10.1111/J.1476-5381.1995.Tb13351.X  0.307
1995 De Kimpe SJ, Hunter ML, Bryant CE, Thiemermann C, Vane JR. Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats. British Journal of Pharmacology. 114: 1317-23. PMID 7542534 DOI: 10.1111/J.1476-5381.1995.Tb13349.X  0.356
1995 Wu C, Thiemermann C, Vane JR. Glibenclamide‐induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat British Journal of Pharmacology. 114: 1273-1281. PMID 7542532 DOI: 10.1111/J.1476-5381.1995.Tb13343.X  0.351
1995 Swierkosz TA, Mitchell JA, Warner TD, Botting RM, Vane JR. Co-induction of nitric oxide synthase and cyclo-oxygenase: Interactions between nitric oxide and prostanoids British Journal of Pharmacology. 114: 1335-1342. PMID 7541688 DOI: 10.1111/J.1476-5381.1995.Tb13353.X  0.401
1995 Wu C, Chen S, Szabó C, Thiemermann C, Vane JR. Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock British Journal of Pharmacology. 114: 1666-1672. PMID 7541282 DOI: 10.1111/J.1476-5381.1995.Tb14955.X  0.317
1995 Akarasereenont P, Mitchell JA, Bakhle YS, Thiemermann C, Vane JR. Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages European Journal of Pharmacology. 273: 121-128. PMID 7537677 DOI: 10.1016/0014-2999(94)00680-6  0.382
1995 Wu C, Croxtall JD, Perretti M, Bryant CE, Thiemermann C, Flower RJ, Vane JR. Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat Proceedings of the National Academy of Sciences of the United States of America. 92: 3473-3477. PMID 7536934 DOI: 10.1073/Pnas.92.8.3473  0.359
1995 Kimpe SJD, Kengatharan M, Thiemermann C, Vane JR. The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure Proceedings of the National Academy of Sciences of the United States of America. 92: 10359-10363. PMID 7479784 DOI: 10.1073/Pnas.92.22.10359  0.34
1995 Swierkosz TA, Warner TD, Vane JR. NG-Hydroxy-L-Arginine Releases from Endothelial Cells Nitric Oxide which Increases cGMP in RFL-6 Fibroblasts Endothelium. 3: 121-129. DOI: 10.3109/10623329509053388  0.404
1995 Kengatharan M, Battistini B, Warner TD, Thiemermann C, Vane JR. Endothelin-1 mediates the increase in ex vivo coronary vascular resistance induced by hemorrhagic shock in the anesthetized rat. Journal of Cardiovascular Pharmacology. 25. DOI: 10.1097/00005344-199506263-00124  0.33
1995 Klemm P, Warner TD, Corder R, Vane JR. Endothelin-1 mediates coronary vasoconstriction caused by exogenous and endogenous cytokines. Journal of Cardiovascular Pharmacology. 25. DOI: 10.1097/00005344-199506263-00123  0.337
1995 Corder R, Carrier M, Khan N, Klemm P, Vane JR. Cytokine regulation of endothelin-1 release from bovine aortic endothelial cells Journal of Cardiovascular Pharmacology. 25. DOI: 10.1097/00005344-199506263-00018  0.313
1995 Kimpe SJD, Thiemermann C, Vane JR. Intracellular release of PAF contributes to the induction of nitric oxide synthase in a model of gram-positive shock Pharmacological Research. 31: 305. DOI: 10.1016/1043-6618(95)87480-1  0.312
1994 Pistelli A, Mollace V, Nistico G, Salvemini D, Vane J. Nitroblue tetrazolium inhibits oxidation of glyceryl trinitrate to nitric oxide in bovine aortic smooth muscle cells Biochemical Pharmacology. 47: 1737-1742. PMID 8204090 DOI: 10.1016/0006-2952(94)90300-X  0.607
1994 Macarthur H, Warner TD, Wood EG, Corder R, Vane JR. Endothelin-1 Release from Endothelial Cells in Culture Is Elevated Both Acutely and Chronically by Short Periods of Mechanical Stretch Biochemical and Biophysical Research Communications. 200: 395-400. PMID 8166711 DOI: 10.1006/Bbrc.1994.1462  0.36
1994 McMurdo L, Thiemermann C, Vane JR. The endothelin ETB receptor agonist, IRL 1620, causes vasodilation and inhibits ex vivo platelet aggregation in the anaesthetised rabbit European Journal of Pharmacology. 259: 51-55. PMID 7957593 DOI: 10.1016/0014-2999(94)90156-2  0.403
1994 Mitchell JA, Belvisi MG, Akarasereenont P, Robbins RA, Kwon O‐, Croxtall JJ, Barnes PJ, Vane JR. Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone British Journal of Pharmacology. 113: 1008-1014. PMID 7858842 DOI: 10.1111/J.1476-5381.1994.Tb17093.X  0.338
1994 Akarasereenont P, Mitchell JA, Appleton I, Thiemermann C, Vane JR. Involvement of tyrosine kinase in the induction of cyclo‐oxygenase and nitric oxide synthase by endotoxin in cultured cells British Journal of Pharmacology. 113: 1522-1528. PMID 7534189 DOI: 10.1111/J.1476-5381.1994.Tb17169.X  0.368
1994 Desai KM, Warner TD, Bishop AE, Polak JM, Vane JR. Nitric oxide, and not vasoactive intestinal peptide, as the main neurotransmitter of vagally induced relaxation of the guinea pig stomach British Journal of Pharmacology. 113: 1197-1202. PMID 7534182 DOI: 10.1111/J.1476-5381.1994.Tb17124.X  0.354
1994 Szabó C, Southan GJ, Thiemermann C, Vane JR. The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites. British Journal of Pharmacology. 113: 757-766. PMID 7532082 DOI: 10.1111/J.1476-5381.1994.Tb17058.X  0.421
1994 Szabó C, Southan GJ, Wood E, Thiemermann C, Vane JR. Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages : requirement of a serum factor British Journal of Pharmacology. 112: 355-356. PMID 7521253 DOI: 10.1111/J.1476-5381.1994.Tb13078.X  0.374
1994 Korbut I, Warner TD, Gryglewski RJ, Vane JR. The effect of nitric oxide synthase inhibition on the plasma fibrinolytic system in septic shock in rats British Journal of Pharmacology. 112: 289-291. PMID 7518306 DOI: 10.1111/J.1476-5381.1994.Tb13066.X  0.41
1993 Wood PJ, Stratford IJ, Adams GE, Szabo C, Thiemermann C, Vane JR. Modification of energy metabolism and radiation response of a murine tumour by changes in nitric oxide availability. Biochemical and Biophysical Research Communications. 192: 505-10. PMID 8484762 DOI: 10.1006/Bbrc.1993.1444  0.308
1993 Salvemini D, Pistelli A, Vane J. Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells British Journal of Pharmacology. 108: 162-169. PMID 8381319 DOI: 10.1111/J.1476-5381.1993.Tb13457.X  0.563
1993 McMurdo L, Lidbury PS, Thiemermann C, Vane JR. Mediation of endothelin-1-induced inhibition of platelet aggregation via the ETB receptor. British Journal of Pharmacology. 109: 530-534. PMID 8358553 DOI: 10.1111/J.1476-5381.1993.Tb13602.X  0.371
1993 Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase Proceedings of the National Academy of Sciences of the United States of America. 90: 11693-11697. PMID 8265610 DOI: 10.1073/Pnas.90.24.11693  0.362
1993 Lidbury PS, Cirillo R, Vane JR. Dissociation of the anti-ischaemic effects of cloricromene from its anti-platelet activity. British Journal of Pharmacology. 110: 275-80. PMID 8220889 DOI: 10.1111/J.1476-5381.1993.Tb13805.X  0.424
1993 Mitchell JA, Kohlhaas KL, Sorrentino R, Warner TD, Murad F, Vane JR. Induction by endotoxin of nitric oxide synthase in the rat mesentery: Lack of effect on action of vasoconstrictors British Journal of Pharmacology. 109: 265-270. PMID 7684306 DOI: 10.1111/J.1476-5381.1993.Tb13563.X  0.358
1993 Cristol JP, Thiemermann C, Mitchell JA, Walder C, Vane JR. Support of renal blood flow after ischaemic-reperfusion injury by endogenous formation of nitric oxide and of cyclo-oxygenase vasodilator metabolites. British Journal of Pharmacology. 109: 188-94. PMID 7684301 DOI: 10.1111/J.1476-5381.1993.Tb13552.X  0.316
1993 Corder R, Harrison VJ, Khan N, Änggård EE, Vane JR. Effects of phosphoramidon in endothelial cell cultures on the endogenous synthesis of endothelin-1 and on conversion of exogenous big endothelin-1 to endothelin-1. Journal of Cardiovascular Pharmacology. 22. PMID 7510004 DOI: 10.1097/00005344-199322008-00021  0.36
1993 Kaw S, Warner TD, Vane JR. The metabolism of endothelin-1 and big endothelin-1 by the isolated perfused kidney of the rabbit Journal of Cardiovascular Pharmacology. 22. PMID 7510001 DOI: 10.1097/00005344-199322008-00019  0.325
1993 Corder R, Khan N, Änggård EE, Vane JR. Calcium ionophores inhibit the release of endothelin-1 from endothelial cells. Journal of Cardiovascular Pharmacology. 22. PMID 7509995 DOI: 10.1097/00005344-199322008-00013  0.367
1993 McMurdo L, Lidbury PS, Corder R, Thiemermann C, Vane JR. Heterogeneous receptors mediate endothelin-1-induced changes in blood pressure, hematocrit, and platelet aggregation. Journal of Cardiovascular Pharmacology. 22. PMID 7509940 DOI: 10.1097/00005344-199322008-00050  0.351
1993 Wellings RP, Warner TD, Thiemermann C, Cristol JP, Corder R, Vane JR. Vasoconstriction in the rat kidney induced by endothelin-1 is blocked by PD 145065 Journal of Cardiovascular Pharmacology. 22. PMID 7509915 DOI: 10.1097/00005344-199322008-00028  0.308
1993 Khatsenko OG, Gross SS, Rifland AB, Vane JR. Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants Proceedings of the National Academy of Sciences of the United States of America. 90: 11147-11151. PMID 7504296 DOI: 10.1073/Pnas.90.23.11147  0.327
1992 Sessa WC, Kaw S, Zembowicz A, Anggård E, Hecker M, Vane JR. Human polymorphonuclear leukocytes generate and degrade endothelin-1 by two distinct neutral proteases. Journal of Cardiovascular Pharmacology. S34-8. PMID 1725374 DOI: 10.1097/00005344-199100177-00010  0.341
1992 Withrington PG, Ansari N, Croxton R, Nucci GD, Vane JR. The actions of endothelins-1 and -3 on the vascular and capsular smooth muscle of the isolated blood perfused spleen of the dog. British Journal of Pharmacology. 105: 490-494. PMID 1559137 DOI: 10.1111/J.1476-5381.1992.Tb14281.X  0.305
1992 Hecker M, Siegle I, MacArthur H, Sessa WC, Vane JR. Role of intracellular thiols in release of EDRF from cultured endothelial cells American Journal of Physiology - Heart and Circulatory Physiology. 262. PMID 1558197 DOI: 10.1152/Ajpheart.1992.262.3.H888  0.398
1992 Sprague RS, Thiemermann C, Vane JR. Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits. Proceedings of the National Academy of Sciences of the United States of America. 89: 8711-5. PMID 1528883 DOI: 10.1073/Pnas.89.18.8711  0.339
1992 Kaw S, Hecker M, Vane JR. The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 89: 6886-6890. PMID 1495979 DOI: 10.1073/Pnas.89.15.6886  0.329
1992 D'Orleans-Juste P, Mitchell JA, Wood EG, Hecker M, Vane JR. Comparison of the release of vasoactive factors from venous and arterial bovine cultured endothelial cells. Canadian Journal of Physiology and Pharmacology. 70: 687-694. PMID 1423010 DOI: 10.1139/Y92-088  0.389
1992 Walder CE, Thiemermann C, Vane JR. NG-hydroxy-L-arginine prevents the haemodynamic effects of nitric oxide synthesis inhibition in the anaesthetized rat. British Journal of Pharmacology. 107: 476-80. PMID 1422593 DOI: 10.1111/J.1476-5381.1992.Tb12770.X  0.326
1992 Salvemini D, Pistelli A, Mollace V, Änggård E, Vane J. The metabolism of glyceryl trinitrate to nitric oxide in the macrophage cell line J774 and its induction by Escherichia coli lipopolysaccharide Biochemical Pharmacology. 44: 17-24. PMID 1378739 DOI: 10.1016/0006-2952(92)90032-E  0.566
1992 Mitchell JA, De Nucci G, Warner TD, Vane JR. Different patterns of release of endothelium-derived relaxing factor and prostacyclin British Journal of Pharmacology. 105: 485-489. PMID 1373103 DOI: 10.1111/J.1476-5381.1992.Tb14280.X  0.359
1992 Zembowicz A, Vane JR. Induction of nitric oxide synthase activity by toxic shock syndrome toxin 1 in a macrophage-monocyte cell line. Proceedings of the National Academy of Sciences of the United States of America. 89: 2051-2055. PMID 1372433 DOI: 10.1073/Pnas.89.6.2051  0.416
1992 Salvemini D, Mollace V, Pistelli A, Anggard E, Vane J. Cultured astrocytoma cells generate a nitric oxide-like factor from endogenous L-arginine and glyceryl trinitrate: Effect of E. coli lipopolysaccharide British Journal of Pharmacology. 106: 931-936. PMID 1327394 DOI: 10.1111/J.1476-5381.1992.Tb14437.X  0.562
1992 Gryglewski RJ, Zembowicz A, Salvemini D, Taylor GW, Vane JR. Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin British Journal of Pharmacology. 106: 838-845. PMID 1327388 DOI: 10.1111/J.1476-5381.1992.Tb14422.X  0.589
1992 Salvemini D, Mollace V, Pistelli A, Anggard E, Vane J. Metabolism of glyceryl trinitrate to nitric oxide by endothelial cells and smooth muscle cells and its induction by Escherichia coli lipopolysaccharide Proceedings of the National Academy of Sciences of the United States of America. 89: 982-986. PMID 1310543 DOI: 10.1073/Pnas.89.3.982  0.554
1992 Zembowicz A, Swierkosz TA, Southan GJ, Hecker M, Gryglewski RJ, Vane JR. Mechanisms of the endothelium-dependent relaxation induced by NG-hydroxy-L-arginine. Journal of Cardiovascular Pharmacology. 20. PMID 1282987 DOI: 10.1097/00005344-199204002-00017  0.402
1992 Kaw S, Hecker M, Southan GJ, Warner TD, Vane JR. Characterization of serine protease-derived metabolites of big endothelin in the cytosolic fraction from human polymorphonuclear leukocytes Journal of Cardiovascular Pharmacology. 20. PMID 1282976 DOI: 10.1097/00005344-199204002-00008  0.323
1992 Hecker M, Walsh DT, Vane JR. Characterization of a microsomal calcium-dependent nitric oxide synthase in activated J774.2 monocyte/macrophages. Journal of Cardiovascular Pharmacology. 20: S139-41. PMID 1282950 DOI: 10.1097/00005344-199204002-00039  0.334
1992 Salvemini D, Pistelli A, Mollace V, Anggard E, Vane J. J774 Cells metabolise glyceryl trinitrate by an enzymic pathway which can be induced by E. colt lipopolysaccharide Pharmacological Research. 26: 229. DOI: 10.1016/1043-6618(92)91167-F  0.521
1991 Mitchell JA, De Nucci G, Warner TD, Vane JR. Alkaline buffers release EDRF from bovine cultured aortic endothelial cells British Journal of Pharmacology. 103: 1295-1302. PMID 1884092 DOI: 10.1111/J.1476-5381.1991.Tb09783.X  0.377
1991 Walder CE, Thiemermann C, Vane JR. The involvement of endothelium-derived relaxing factor in the regulation of renal cortical blood flow in the rat. British Journal of Pharmacology. 102: 967-73. PMID 1855125 DOI: 10.1111/J.1476-5381.1991.Tb12285.X  0.353
1991 MacIntyre I, Zaidi M, Alam ASMT, Datta HK, Moonga BS, Lidbury PS, Hecker M, Vane JR. Osteoclastic inhibition: An action of nitric oxide not mediated by cyclic GMP Proceedings of the National Academy of Sciences of the United States of America. 88: 2936-2940. PMID 1849281 DOI: 10.1073/Pnas.88.7.2936  0.315
1991 Thiemermann C, Mustafa M, Mester PA, Mitchell JA, Hecker M, Vane JR. Inhibition of the release of endothelium‐derived relaxing factor in vitro and in vivo by dipeptides containing NG‐nitro‐l‐arginine British Journal of Pharmacology. 104: 31-38. PMID 1786515 DOI: 10.1111/J.1476-5381.1991.Tb12380.X  0.371
1991 Mollace V, Salvemini D, Vane J. Studies on the importance of the proposed release of nitric oxide from platelets Thrombosis Research. 65: 533-542. PMID 1725563 DOI: 10.1016/S0049-3848(05)80002-7  0.571
1991 D'Orléans-Juste P, Lidbury PS, Telemaque S, Warner TD, Vane JR. Human big endothelin releases prostacyclin in vivo and in vitro through a phosphoramidon-sensitive conversion to endothelin-1 Journal of Cardiovascular Pharmacology. 17: S251-S255. PMID 1725347 DOI: 10.1097/00005344-199100177-00072  0.351
1991 Mollace V, Salvemini D, Anggard E, Vane J. Nitric oxide from vascular smooth muscle cells: Regulation of platelet reactivity and smooth muscle cell guanylate cyclase British Journal of Pharmacology. 104: 633-638. PMID 1724627 DOI: 10.1111/J.1476-5381.1991.Tb12481.X  0.584
1991 Hecker M, Walsh DT, Vane JR. On the substrate specificity of nitric oxide synthase. Febs Letters. 294: 221-4. PMID 1721880 DOI: 10.1016/0014-5793(91)81434-A  0.34
1991 Masini E, Salvemini D, Pistelli A, Mannaioni PF, Vane JR. Rat mast cells synthesize a nitric oxide like-factor which modulates the release of histamine Agents and Actions. 33: 61-63. PMID 1716838 DOI: 10.1007/Bf01993127  0.629
1991 Salvemini D, Radziszewski W, Mollace V, Moore A, Willoughby D, Vane J. Diphenylene iodonium, an inhibitor of free radical formation, inhibits platelet aggregation European Journal of Pharmacology. 199: 15-18. PMID 1716574 DOI: 10.1016/0014-2999(91)90631-Y  0.593
1991 Masini E, Mannaioni PF, Pistelli A, Salvemini D, Vane J. Impairment of the L-arginine-nitric oxide pathway in mast cells from spontaneously hypertensive rats Biochemical and Biophysical Research Communications. 177: 1178-1182. PMID 1711845 DOI: 10.1016/0006-291X(91)90664-S  0.569
1991 Desai KM, Zembowicz A, Sessa WC, Vane JR. Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig. Proceedings of the National Academy of Sciences of the United States of America. 88: 11490-4. PMID 1684865 DOI: 10.1073/Pnas.88.24.11490  0.378
1991 Desai KM, Sessa WC, Vane JR. Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature. 351: 477-9. PMID 1675430 DOI: 10.1038/351477A0  0.33
1991 Zembowicz A, Hecker M, Macarthur H, Sessa WC, Vane JR. Nitric oxide and another potent vasodilator are formed from NG-hydroxy-L-arginine by cultured endothelial cells Proceedings of the National Academy of Sciences of the United States of America. 88: 11172-11176. PMID 1662386 DOI: 10.1073/Pnas.88.24.11172  0.352
1991 Salvemini D, De Nucci G, Vane JR. Superoxide dismutase cooperates with prostacyclin to inhibit platelet aggregation: a comparative study in washed platelets and platelet rich plasma Thrombosis and Haemostasis. 65: 421-424. PMID 1647553  0.536
1991 Vane JR, Botting RM. Endothelium-derived vasoactive factors and the control of the circulation. Seminars in Perinatology. 15: 4-10. DOI: 10.5555/Uri:Pii:014600059190067Z  0.407
1991 Hecker M, Sessa WC, Mitchell JA, Änggård EE, Vane JR. The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen Journal of Cardiovascular Pharmacology. 17: S19-S24. DOI: 10.1097/00005344-199117003-00005  0.354
1991 Salvemini D, Masini E, Pistelli A, Mannaioni PF, Vane J. Nitric Oxide: A Regulatory Mediator of Mast Cell Reactivity Journal of Cardiovascular Pharmacology. 17. DOI: 10.1097/00005344-199100001-00046  0.618
1991 Salvemini D, Masini E, Pistelli A, Mannaioni PF, Vane J. Nitric oxide: A regulatory mediator of mast cell reactivity Journal of Cardiovascular Pharmacology. 17.  0.603
1990 Hecker M, Mitchell JA, Harris HJ, Katsura M, Thiemermann C, Vane JR. Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine. Biochemical and Biophysical Research Communications. 167: 1037-43. PMID 2322257 DOI: 10.1016/0006-291X(90)90627-Y  0.31
1990 Mitchell JA, Hecker M, Vane JR. The generation of L-arginine in endothelial cells is linked to the release of endothelium-derived relaxing factor. European Journal of Pharmacology. 176: 253-254. PMID 2311672 DOI: 10.1016/0014-2999(90)90541-D  0.339
1990 Mollace V, Salvemini D, Änggård E, Vane J. Cultured astrocytoma cells inhibit platelet aggregation by releasing a nitric oxide-like factor Biochemical and Biophysical Research Communications. 172: 564-569. PMID 2241954 DOI: 10.1016/0006-291X(90)90710-5  0.586
1990 Hecker M, Sessa WC, Harris HJ, Anggård EE, Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proceedings of the National Academy of Sciences of the United States of America. 87: 8612-6. PMID 2236071 DOI: 10.1073/Pnas.87.21.8612  0.336
1990 Mitchell JA, Hecker M, Ånggård EE, Vane JR. Cultured endothelial cells maintain their L-arginine level despite the continuous release of EDRF. European Journal of Pharmacology. 182: 573-576. PMID 2226624 DOI: 10.1016/0014-2999(90)90058-E  0.355
1990 Thiemermann C, May GR, Page CP, Vane JR. Endothelin-1 inhibits platelet aggregation in vivo: a study with 111indium-labelled platelets. British Journal of Pharmacology. 99: 303-8. PMID 2183912 DOI: 10.1111/J.1476-5381.1990.Tb14699.X  0.413
1990 Salvemini D, Korbut R, Änggård E, Vane J. Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide Proceedings of the National Academy of Sciences of the United States of America. 87: 2593-2597. PMID 2181441 DOI: 10.1073/Pnas.87.7.2593  0.637
1990 Lidbury PS, Korbut R, Vane JR. Sodium nitroprusside modulates the fibrinolytic system in the rabbit. British Journal of Pharmacology. 101: 527-530. PMID 2127549 DOI: 10.1111/J.1476-5381.1990.Tb14115.X  0.312
1990 Lidbury PS, Thiemermann C, Korbut R, Vane JR. Endothelins release tissue plasminogen activator and prostanoids. European Journal of Pharmacology. 186: 205-212. PMID 2127021 DOI: 10.1016/0014-2999(90)90435-9  0.391
1990 Vane JR, Änggård EE, Botting RM. Regulatory functions of the vascular endothelium. The New England Journal of Medicine. 323: 27-36. PMID 2113184 DOI: 10.1056/Nejm199007053230106  0.313
1990 Spurej E, Sneddon JM, Vane JR. The influence of pH on aggregation of human washed platelets induced by thrombin or collagen. Blood Coagulation & Fibrinolysis. 1: 47-53. PMID 2102788 DOI: 10.1097/00001721-199003000-00008  0.383
1990 Walder CE, Thiemermann C, Vane JR. Endothelium-derived relaxing factor participates in the increased blood flow in response to pentagastrin in the rat stomach mucosa. Proceedings. Biological Sciences / the Royal Society. 241: 195-200. PMID 1979444 DOI: 10.1098/Rspb.1990.0085  0.385
1990 Sessa WC, Hecker M, Mitchell JA, Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 8607-11. PMID 1978327 DOI: 10.1073/Pnas.87.21.8607  0.324
1990 Salvemini D, Masini E, Anggard E, Mannaioni PF, Vane J. Synthesis of a nitric oxide-like factor from L-arginine by rat serosal mast cells: Stimulation of guanylate cyclase and inhibition of platelet aggregation Biochemical and Biophysical Research Communications. 169: 596-601. PMID 1972620 DOI: 10.1016/0006-291X(90)90372-T  0.593
1990 Sinzinger H, Fitscha P, O'Grady J, Rauscha F, Rogatti W, Vane J. Synergistic effect of prostaglandin E1 and isosorbide dinitrate in peripheral vascular disease. The Lancet. 335: 627-628. PMID 1969017 DOI: 10.1016/0140-6736(90)90412-X  0.369
1990 Salvemini D, Radziszewski W, Korbut R, Vane J. The use of oxyhaemoglobin to explore the events underlying inhibition of platelet aggregation induced by NO or NO-donors British Journal of Pharmacology. 101: 991-995. PMID 1707709 DOI: 10.1111/J.1476-5381.1990.Tb14194.X  0.56
1990 Mollace V, Salvemini D, Änggard E, Nisticò G, Vane J. Cultured astrocytoma cells release a nitric oxide-like factor Pharmacological Research. 22: 338. DOI: 10.1016/S1043-6618(09)80358-7  0.542
1990 Mannaioni PF, Masini E, Salvemini D, Pistelli A, Korbut R, Vane JR. Mast cell derived relaxing factor and the effect of nitric oxide generators on mast cell histamine release European Journal of Pharmacology. 183: 711. DOI: 10.1016/0014-2999(90)92505-D  0.559
1989 Lidbury PS, Thiemermann C, Thomas GR, Vane JR. Endothelin-3: selectivity as an anti-aggregatory peptide in vivo European Journal of Pharmacology. 166: 335-338. PMID 2676565 DOI: 10.1016/0014-2999(89)90079-4  0.429
1989 Korbut R, Lidbury P, Thomas GR, Vane JR. Fibrinolytic activity of endothelin-3 Thrombosis Research. 55: 797-799. PMID 2675389 DOI: 10.1016/0049-3848(89)90311-3  0.304
1989 Botting R, Vane JR. Mediators and the anti-thrombotic properties of the vascular endothelium. Annals of Medicine. 21: 31-8. PMID 2647108 DOI: 10.3109/07853898909149179  0.315
1989 Warner TD, de Nucci G, Vane JR. Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat European Journal of Pharmacology. 159: 325-326. PMID 2646137 DOI: 10.1016/0014-2999(89)90167-2  0.315
1989 Salvemini D, De Nucci G, Sneddon JM, Vane JR. Superoxide anions enhance platelet adhesion and aggregation British Journal of Pharmacology. 97: 1145-1150. PMID 2551440 DOI: 10.1111/J.1476-5381.1989.Tb12572.X  0.524
1989 Salvemini D, De Nucci G, Gryglewski RJ, Vane JR. Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor Proceedings of the National Academy of Sciences of the United States of America. 86: 6328-6332. PMID 2548208 DOI: 10.1073/Pnas.86.16.6328  0.632
1989 Salvemini D, Korbut R, Änggård E, Vane JR. Lipopolysaccharide increases release of a nitric oxide-like factor from endothelial cells European Journal of Pharmacology. 171: 135-136. PMID 2515068 DOI: 10.1016/0014-2999(89)90437-8  0.549
1989 Barrett ML, Willis AL, Vane JR. Inhibition of platelet-derived mitogen release by nitric oxide (EDRF). Agents and Actions. 27: 488-91. PMID 2508448 DOI: 10.1007/Bf01972860  0.423
1989 Warner TD, De Nucci G, Vane JR. Comparison of the survival of endothelium-derived relaxing factor and nitric oxide within the isolated perfused mesenteric arterial bed of the rat British Journal of Pharmacology. 97: 777-782. PMID 2503227 DOI: 10.1111/J.1476-5381.1989.Tb12016.X  0.345
1989 Walder CE, Thomas GR, Thiemermann C, Vane JR. The hemodynamic effects of endothelin-1 in the pithed rat. Journal of Cardiovascular Pharmacology. 13: S93-7; discussion S1. PMID 2473337 DOI: 10.1097/00005344-198900135-00023  0.328
1989 Rae GA, Trybulec M, Nucci Gd, Vane JR. Endothelin-1 releases eicosanoids from rabbit isolated perfused kidney and spleen. Journal of Cardiovascular Pharmacology. 13. PMID 2473336 DOI: 10.1097/00005344-198900135-00022  0.337
1989 Thiemermann C, Lidbury PS, Thomas GR, Vane JR. Endothelin-1 releases prostacyclin and inhibits ex vivo platelet aggregation in the anesthetized rabbit. Journal of Cardiovascular Pharmacology. 13. DOI: 10.1097/00005344-198900135-00034  0.416
1988 Thomas GR, Thiemermann C, Walder C, Vane JR. The effects of endothelium-dependent vasodilators on cardiac output and their distribution in the anaesthetized rat: a comparison with sodium nitroprusside. British Journal of Pharmacology. 95: 986-92. PMID 3264737 DOI: 10.1111/J.1476-5381.1988.Tb11729.X  0.326
1988 Sneddon JM, Vane JR. Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells Proceedings of the National Academy of Sciences of the United States of America. 85: 2800-2804. PMID 3258664 DOI: 10.1073/Pnas.85.8.2800  0.416
1988 Thiemermann C, Lidbury P, Thomas R, Vane J. Endothelin inhibits ex vivo platelet aggregation in the rabbit. European Journal of Pharmacology. 158: 181-182. PMID 3065092 DOI: 10.1016/0014-2999(88)90273-7  0.38
1988 Gryglewski RJ, Botting RM, Vane JR. Mediators produced by the endothelial cell. Hypertension. 12: 530-548. PMID 3060428 DOI: 10.1161/01.Hyp.12.6.530  0.432
1988 de Nucci G, Thomas R, D'Orleans-Juste P, Antunes E, Walder C, Warner TD, Vane JR. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proceedings of the National Academy of Sciences of the United States of America. 85: 9797-800. PMID 3059352 DOI: 10.1073/Pnas.85.24.9797  0.315
1988 De Nucci G, Warner T, Vane JR. Effect of captopril on the bradykinin-induced release of prostacyclin from guinea-pig lungs and bovine aortic endothelial cells British Journal of Pharmacology. 95: 783-788. PMID 2850062 DOI: 10.1111/J.1476-5381.1988.Tb11705.X  0.352
1988 De Nucci G, Gryglewski RJ, Warner TD, Vane JR. Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled Proceedings of the National Academy of Sciences of the United States of America. 85: 2334-2338. PMID 2832851 DOI: 10.1073/Pnas.85.7.2334  0.378
1987 Vane J. The evolution of non-steroidal anti-inflammatory drugs and their mechanisms of action. Drugs. 33: 18-27. PMID 3595474 DOI: 10.2165/00003495-198700331-00005  0.32
1987 Higgs GA, Salmon JA, Henderson B, Vane JR. Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity Proceedings of the National Academy of Sciences of the United States of America. 84: 1417-1420. PMID 3103135 DOI: 10.1073/Pnas.84.5.1417  0.358
1987 Vane JR, Gryglewski RJ, Botting RM. The endothelial cell as a metabolic and endocrine organ Trends in Pharmacological Sciences. 8: 491-496. DOI: 10.1016/0165-6147(87)90045-9  0.377
1984 Oliva D, Noè A, Nicosia S, Bernini F, Fumagalli R, Whittle BJR, Moncada S, Vane JR. Prostacyclin-sensitive adenylate cyclase in cultured myocytes: Differences between rabbit aorta and mesenteric artery European Journal of Pharmacology. 105: 207-213. PMID 6391937 DOI: 10.1016/0014-2999(84)90611-3  0.342
1984 Higgs GA, Mugridge KG, Moncada S, Vane JR. Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW755C Proceedings of the National Academy of Sciences of the United States of America. 81: 2890-2892. PMID 6326150 DOI: 10.1073/Pnas.81.9.2890  0.34
1983 Whittle BJR, Monacada S, Mullane K, Vane JR. Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue Prostaglandins. 25: 205-223. PMID 6344147 DOI: 10.1016/0090-6980(83)90105-3  0.4
1981 Moncada S, Vane JR. Prostacyclin: its biosynthesis, actions and clinical potential. Philosophical Transactions of the Royal Society B. 294: 305-329. PMID 6117893 DOI: 10.1098/Rstb.1981.0108  0.406
1980 Higgs GA, Eakins KE, Mugridge KG, Moncada S, Vane Jr. The effects of non-steroid anti-inflammatory drugs on leukocyte migration in carrageenin-induced inflammation European Journal of Pharmacology. 66: 81-86. PMID 7408965 DOI: 10.1016/0014-2999(80)90297-6  0.343
1980 Whittle BJR, Moncada S, Whiting F, Vane JR. Carbacyclin - A potent stable prost acyclin analogue for the inhibition of platelet aggregation Prostaglandins. 19: 605-627. PMID 6992234 DOI: 10.1016/S0090-6980(80)80010-4  0.414
1980 Whittle BJR, Higgs GA, Eakins KE, Moncada S, Vane JR. Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa Nature. 284: 271-273. PMID 6767192 DOI: 10.1038/284271A0  0.312
1980 Chapple DJ, Dusting GJ, Hughes R, Vane JR. Some direct and reflex cardiovascular actions of prostacyclin (PGI2) and prostaglandin E2 in anaesthetized dogs. British Journal of Pharmacology. 68: 437-447. PMID 6762901 DOI: 10.1111/J.1476-5381.1980.Tb14557.X  0.314
1979 Gryglewski RJ, Salmon JA, Ubatuba FB, Weatherly BC, Moncada S, Vane JR. Effects of all CIS-5, 8,11,14,17 eicosapentaenoic acid and PGH3 on platelet aggregation Prostaglandins. 18: 453-478. PMID 531220 DOI: 10.1016/S0090-6980(79)80063-5  0.395
1979 Mullane KM, Dusting GJ, Salmon JA, Moncada S, Vane JR. Biotransformation and cardiovascular effects of arachidonic acid in the dog. European Journal of Pharmacology. 54: 217-228. PMID 428423 DOI: 10.1016/0014-2999(79)90080-3  0.363
1979 Higgs GA, Cardinal DC, Moncada S, Vane JR. Microcirculatory effects of prostacyclin (PGI2) in the hamster cheek pouch. Microvascular Research. 18: 245-254. PMID 386050 DOI: 10.1016/0026-2862(79)90032-3  0.362
1979 Dusting GJ, Moncada S, Vane JR. Prostaglandins, their intermediates and precursors: Cardiovascular actions and regulatory roles in normal and abnormal circulatory systems Progress in Cardiovascular Diseases. 21: 405-430. PMID 375296 DOI: 10.1016/0033-0620(79)90024-0  0.336
1979 Herman AG, Claeys M, Moncada S, Vane JR. Biosynthesis of prostacyclin (PGI2) and 12L-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) by pericardium, pleura, peritoneum and aorta of the rabbit Prostaglandins. 18: 439-452. PMID 119280 DOI: 10.1016/S0090-6980(79)80062-3  0.373
1979 Higgs GA, Flower RJ, Vane JR. A new approach to anti-inflammatory drugs. Biochemical Pharmacology. 28: 1959-1961. PMID 110332 DOI: 10.1016/0006-2952(79)90651-8  0.362
1979 Longmore DB, Gueirrara D, Bennett G, Smith M, Bunting S, Moncada S, Reed P, Read NG, Vane JR. PROSTACYCLIN: A SOLUTION TO SOME PROBLEMS OF EXTRACORPOREAL CIRCULATION: Experiments in Greyhounds The Lancet. 313: 1002-1005. PMID 86720 DOI: 10.1016/S0140-6736(79)92756-9  0.326
1979 Ubatuba FB, Moncada S, Vane JR. The effect of prostacyclin (PGT2) on platelet behaviour. Thrombus formation in vivo and bleeding time. Thrombosis and Haemostasis. 41: 425-435. DOI: 10.1055/S-0038-1646791  0.422
1978 Blackwell GJ, Flower RJ, Nijkamp FP, Vane JR. Phospholipase A2 activity of guinea-pig isolated perfused lungs: stimulation, and inhibition by anti-inflammatory steroids. British Journal of Pharmacology. 62: 79-89. PMID 620100 DOI: 10.1111/J.1476-5381.1978.Tb07009.X  0.334
1978 Salmon JA, Smith DR, Flower RJ, Moncada S, Vane JR. Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes. Biochimica Et Biophysica Acta. 523: 250-262. PMID 415760 DOI: 10.1016/0005-2744(78)90028-1  0.302
1978 Dusting GJ, Moncada S, Mullane KM, Vane JR. Implications of prostacyclin generation for modulation of vascular tone. Clinical Science. 4. PMID 365431 DOI: 10.1042/Cs055195S  0.332
1978 Whittle BJR, Moncada S, Vane JR. Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species. Prostaglandins. 16: 373-388. PMID 364545 DOI: 10.1016/0090-6980(78)90216-2  0.404
1978 Dusting GJ, Moncada S, Vane JR. Recirculation of prostacyclin (PGI2) in the dog. British Journal of Pharmacology. 64: 315-320. PMID 361136 DOI: 10.1111/J.1476-5381.1978.Tb17307.X  0.307
1978 Higgs EA, Moncada S, Vane JR. Inflammatory effects of prostacyclin (PGI2) and 6-oxo-PGF1α in the rat paw Prostaglandins. 16: 153-162. PMID 360302 DOI: 10.1016/0090-6980(78)90018-7  0.336
1978 Higgs EA, Moncada S, Vane JR, Caen JP, Michel H, Tobelem G. Effect of prostacyclin (PGI2) on platelet adhesion to rabbit arterial subendothelium. Prostaglandins. 16: 17-22. PMID 360299 DOI: 10.1016/0090-6980(78)90197-1  0.392
1978 Whittle BJR, Boughton-Smith NK, Moncada S, Vane JR. Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1α on the rat gastric mucosa in vivo and in vitro Prostaglandins. 15: 955-967. PMID 358297 DOI: 10.1016/0090-6980(78)90038-2  0.332
1978 Bunting S, Moncada S, Reed P, Salmon JA, Vane JR. An antiserum to 5,6-dihydro prostacyclin (PGI1) which also binds prostacyclin. Prostaglandins. 15: 565-73. PMID 353902 DOI: 10.1016/0090-6980(78)90053-9  0.403
1978 Moncada S, Korbut R, Bunting S, Vane JR. Prostacyclin is a circulating hormone Nature. 273: 767-768. PMID 351418 DOI: 10.1038/273767A0  0.406
1978 Dusting GJ, Moncada S, Vane JR. Vascular actions of arachidonic acid and its metabolites in perfused mesenteric and femoral beds of the dog. European Journal of Pharmacology. 49: 65-72. PMID 350595 DOI: 10.1016/0014-2999(78)90222-4  0.377
1978 Armstrong JM, Lattimer N, Moncada S, Vane JR. COMPARISON OF THE VASODEPRESSOR EFFECTS OF PROSTACYCLIN AND 6-OXO-PROSTAGLANDIN F1α WITH THOSE OF PROSTAGLANDIN E2 IN RATS AND RABBITS British Journal of Pharmacology. 62: 125-130. PMID 339981 DOI: 10.1111/J.1476-5381.1978.Tb07014.X  0.336
1978 Schrör K, Moncada S, Ubatuba FB, Vane JR. Transformation of arachidonic acid and prostaglandin endoperoxides by the guinea pig heart. Formation of RCS and prostacyclin. European Journal of Pharmacology. 47: 103-114. PMID 338313 DOI: 10.1016/0014-2999(78)90380-1  0.327
1978 Woods HF, Ash G, Weston MJ, Bunting S, Moncada S, Vane JR. PROSTACYCLIN CAN REPLACE HEPARIN IN HÆMODIALYSIS IN DOGS The Lancet. 312: 1075-1077. PMID 82090 DOI: 10.1016/S0140-6736(78)91806-8  0.364
1978 Dyerberg J, Bang HO, Stoffersen E, Moncada S, Vane JR. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis The Lancet. 312: 117-119. PMID 78322 DOI: 10.1016/S0140-6736(78)91505-2  0.306
1977 Cottee F, Flower RJ, Moncada S, Salmon JA, Vane JR. Synthesis of 6-keto-PGF1α by ram seminal vesicle microsomes Prostaglandins. 14: 413-423. PMID 905569 DOI: 10.1016/0090-6980(77)90257-X  0.33
1977 Blackwell GJ, Duncombe WG, Flower RJ, Parsons MF, Vane JR. The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs. British Journal of Pharmacology. 59: 353-366. PMID 837023 DOI: 10.1111/J.1476-5381.1977.Tb07500.X  0.391
1977 Moncada S, Bunting S, Mullane K, Thorogood P, Vane JR, Raz A, Needleman P. Imidazole: a selective inhibitor of thromboxane synthetase. Prostaglandins. 13: 611-8. PMID 558637 DOI: 10.1016/0090-6980(77)90232-5  0.347
1977 Nijkamp FP, Moncada S, White HL, Vane JR. Diversion of prostaglandin endoperoxide metabolism by selective inhibition of thromboxane A2 biosynthesis in lung, spleen or platelets European Journal of Pharmacology. 44: 179-186. PMID 407090 DOI: 10.1016/0014-2999(77)90104-2  0.364
1977 Moncada S, Herman AG, Higgs EA, Vane JR. Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium. Thrombosis Research. 11: 323-344. PMID 335560 DOI: 10.1016/0049-3848(77)90185-2  0.344
1977 Moncada S, Higgs EA, Vane JR. Human Arterial And Venous Tissues Generate Prostacyclin (Prostaglandin X), A Potent Inhibitor Of Platelet Aggregation The Lancet. 309: 18-21. PMID 63657 DOI: 10.1016/S0140-6736(77)91655-5  0.382
1977 Moncada S, Grylewski R, Bunting S, Vane JR. An Enzyme Isolated from Arteries Transforms Prostaglandin Endoperoxides to an Unstable Substance that Inhibits Platelet Aggregation. Cheminform. 8. DOI: 10.1002/Chin.197706329  0.355
1976 Bunting S, Moncada S, Vane JR, Gryglewski R. Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation Prostaglandins. 12: 897-913. PMID 1005741 DOI: 10.1016/0090-6980(76)90125-8  0.417
1976 Higgs GA, Bunting S, Moncada S, Vane JR. Polymorphonuclear leukocytes produce thromboxane A2-like activity during phagocytosis Prostaglandins. 12: 749-757. PMID 981700 DOI: 10.1016/0090-6980(76)90050-2  0.329
1976 Nijkamp FP, Flower RJ, Moncada S, Vane JR. Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids Nature. 263: 479-482. PMID 972692 DOI: 10.1038/263479A0  0.34
1976 Moncada S, Needleman P, Bunting S, Vane JR. Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition. Prostaglandins. 12: 323-35. PMID 968048 DOI: 10.1016/0090-6980(76)90014-9  0.332
1976 Needleman P, Moncada S, Bunting S, Vane JR, Hamberg M, Samuelsson B. Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature. 261: 558-60. PMID 934294 DOI: 10.1038/261558A0  0.335
1976 Moncada S, Gryglewski RJ, Bunting S, Vane JR. A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation Prostaglandins. 12: 715-737. PMID 824686 DOI: 10.1016/0090-6980(76)90048-4  0.402
1976 Gryglewski RJ, Bunting S, Moncada S, Flower RJ, Vane JR. Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides Prostaglandins. 12: 685-713. PMID 824685 DOI: 10.1016/0090-6980(76)90047-2  0.422
1976 Moncada S, Gryglewski R, Bunting S, Vane JR. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation Nature. 263: 663-665. PMID 802670 DOI: 10.1038/263663A0  0.407
1956 DAWES GS, VANE JR. The refractory period of atria isolated from mammalian hearts. The Journal of Physiology. 132: 611-29. PMID 13332598  0.414
1953 BORN GV, VANE JR. Gastric secretion induced by histamine. The Journal of Physiology. 121: 445-51. PMID 13097384  0.457
1953 DAWES GS, MOTT JC, VANE JR. The density flowmeter, a direct method for the measurement of the rate of blood flow. The Journal of Physiology. 121: 72-9. PMID 13085300  0.426
1952 BORN GV, VANE JR. The quantitative determination of diffusible histamine in blood. British Journal of Pharmacology and Chemotherapy. 7: 298-303. PMID 14954128  0.436
1949 BURN JH, VANE JR. The relation between the motor and inhibitor actions of acetylcholine. The Journal of Physiology. 108: 104-15. PMID 18128151 DOI: 10.1113/jphysiol.1949.sp004314  0.556
1948 BURN JH, VANE JR. The inhibitory action of paludrine on the secretion of gastric juice. British Journal of Pharmacology and Chemotherapy. 3: 346-9. PMID 18102606  0.566
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