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Robbie J. Loewith, Ph.D. - Publications

Affiliations: 
2000 University of Calgary, Calgary, Alberta, Canada 
Area:
Molecular Biology
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59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Prouteau M, Bourgoint C, Felix J, Bonadei L, Sadian Y, Gabus C, Savvides SN, Gutsche I, Desfosses A, Loewith R. EGOC inhibits TOROID polymerization by structurally activating TORC1. Nature Structural & Molecular Biology. PMID 36702972 DOI: 10.1038/s41594-022-00912-6  0.324
2022 Tafur L, Hinterndorfer K, Gabus C, Lamanna C, Bergmann A, Sadian Y, Hamdi F, Kyrilis FL, Kastritis PL, Loewith R. Cryo-EM structure of the SEA complex. Nature. 611: 399-404. PMID 36289347 DOI: 10.1038/s41586-022-05370-0  0.349
2020 Tafur L, Kefauver J, Loewith R. Structural Insights into TOR Signaling. Genes. 11: 885. PMID 32759652 DOI: 10.3390/Genes11080885  0.421
2020 Schmidt O, Weyer Y, Sprenger S, Widerin MA, Eising S, Baumann V, Angelova M, Loewith R, Stefan CJ, Hess MW, Fröhlich F, Teis D. TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast. The Journal of Biological Chemistry. PMID 32611771 DOI: 10.1074/Jbc.Ra120.013222  0.411
2020 Riggi M, Kusmider B, Loewith R. The flipside of the TOR coin - TORC2 and plasma membrane homeostasis at a glance. Journal of Cell Science. 133. PMID 32393676 DOI: 10.1242/Jcs.242040  0.503
2020 Plank M, Perepelkina M, Müller M, Vaga S, Zou X, Bourgoint C, Berti M, Saarbach J, Haesendonckx S, Winssinger N, Aebersold R, Loewith R. Chemical genetics of AGC-kinases reveals shared targets of Ypk1, Protein Kinase A and Sch9. Molecular & Cellular Proteomics : McP. PMID 32102971 DOI: 10.1074/Mcp.Ra120.001955  0.428
2019 Serbyn N, Noireterre A, Bagdiul I, Plank M, Michel AH, Loewith R, Kornmann B, Stutz F. The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast. Molecular Cell. PMID 31902667 DOI: 10.1016/J.Molcel.2019.12.007  0.383
2019 Collado J, Kalemanov M, Campelo F, Bourgoint C, Thomas F, Loewith R, Martínez-Sánchez A, Baumeister W, Stefan CJ, Fernández-Busnadiego R. Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity. Developmental Cell. 51: 476-487.e7. PMID 31743662 DOI: 10.1016/J.Devcel.2019.10.018  0.314
2019 Riggi M, Bourgoint C, Macchione M, Matile S, Loewith R, Roux A. TORC2 controls endocytosis through plasma membrane tension. The Journal of Cell Biology. PMID 31123183 DOI: 10.1083/Jcb.201901096  0.452
2019 Prouteau M, Loewith R. TOR Signaling Is Going through a Phase. Cell Metabolism. 29: 1019-1021. PMID 31067446 DOI: 10.1016/J.Cmet.2019.04.010  0.316
2019 Loewith R, Riezman H, Winssinger N. Sphingolipids and membrane targets for therapeutics. Current Opinion in Chemical Biology. 50: 19-28. PMID 30897494 DOI: 10.1016/J.Cbpa.2019.02.015  0.323
2018 Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R. Decrease in plasma membrane tension triggers PtdIns(4,5)P phase separation to inactivate TORC2. Nature Cell Biology. 20: 1043-1051. PMID 30154550 DOI: 10.1038/S41556-018-0150-Z  0.302
2018 Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell SB, Prouteau M, Loewith R. Target of rapamycin complex 2–dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae Journal of Biological Chemistry. 293: 12043-12053. PMID 29895620 DOI: 10.1074/Jbc.Ra117.001615  0.443
2017 Karuppasamy M, Kusmider B, Oliveira TM, Gaubitz C, Prouteau M, Loewith RJ, Schaffitzel C. Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2 Nature Communications. 8: 1729-1729. PMID 29170376 DOI: 10.1038/S41467-017-01862-0  0.441
2017 Prouteau M, Desfosses A, Sieben C, Bourgoint C, Lydia Mozaffari N, Demurtas D, Mitra AK, Guichard P, Manley S, Loewith R. TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity. Nature. PMID 28976958 DOI: 10.1038/Nature24021  0.476
2017 Eapen VV, Waterman DP, Bernard A, Schiffmann N, Sayas E, Kamber R, Lemos B, Memisoglu G, Ang J, Mazella A, Chuartzman SG, Loewith RJ, Schuldiner M, Denic V, Klionsky DJ, et al. A pathway of targeted autophagy is induced by DNA damage in budding yeast. Proceedings of the National Academy of Sciences of the United States of America. PMID 28154131 DOI: 10.1073/Pnas.1614364114  0.362
2017 Primo C, Ferri-Blázquez A, Loewith RJ, Yenush L. Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation. Journal of Biological Chemistry. 292: 563-574. PMID 27895122 DOI: 10.1074/Jbc.M116.746982  0.456
2016 Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, et al. Dual action antifungal small molecule modulates multidrug efflux and TOR signaling. Nature Chemical Biology. PMID 27571477 DOI: 10.1038/Nchembio.2165  0.337
2016 Gaubitz C, Prouteau M, Kusmider B, Loewith RJ. TORC2 Structure and Function. Trends in Biochemical Sciences. 41: 532-545. PMID 27161823 DOI: 10.1016/J.Tibs.2016.04.001  0.385
2016 Yerlikaya S, Meusburger M, Kumari R, Huber A, Anrather D, Costanzo M, Boone C, Ammerer G, Baranov PV, Loewith R. TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae. Molecular Biology of the Cell. 27: 397-409. PMID 26582391 DOI: 10.1091/Mbc.E15-08-0594  0.455
2016 Eltschinger S, Loewith RJ. TOR Complexes and the Maintenance of Cellular Homeostasis. Trends in Cell Biology. 26: 148-159. PMID 26546292 DOI: 10.1016/J.Tcb.2015.10.003  0.485
2015 Gaubitz C, Oliveira TM, Prouteau M, Leitner A, Karuppasamy M, Konstantinidou G, Rispal D, Eltschinger S, Robinson GC, Thore S, Aebersold R, Schaffitzel C, Loewith R. Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. Molecular Cell. 58: 977-88. PMID 26028537 DOI: 10.1016/J.Molcel.2015.04.031  0.45
2015 Rispal D, Eltschinger S, Stahl M, Vaga S, Bodenmiller B, Abraham Y, Filipuzzi I, Movva NR, Aebersold R, Helliwell SB, Loewith R. Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways. The Journal of Biological Chemistry. 290: 14963-78. PMID 25882841 DOI: 10.1074/Jbc.M114.627794  0.474
2014 da Silveira Dos Santos AX, Riezman I, Aguilera-Romero MA, David F, Piccolis M, Loewith R, Schaad O, Riezman H. Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis. Molecular Biology of the Cell. 25: 3234-46. PMID 25143408 DOI: 10.1091/Mbc.E14-03-0851  0.424
2014 Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, Weisman LS. Roles for PI(3,5)P2 in nutrient sensing through TORC1. Molecular Biology of the Cell. 25: 1171-85. PMID 24478451 DOI: 10.1091/Mbc.E14-01-0021  0.444
2014 Kennedy MA, Gable K, Niewola-Staszkowska K, Abreu S, Johnston A, Harris LJ, Reggiori F, Loewith R, Dunn T, Bennett SA, Baetz K. A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast. Plos Genetics. 10: e1004010. PMID 24465216 DOI: 10.1371/Journal.Pgen.1004010  0.357
2013 Shimada K, Filipuzzi I, Stahl M, Helliwell SB, Studer C, Hoepfner D, Seeber A, Loewith R, Movva NR, Gasser SM. TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks. Molecular Cell. 51: 829-39. PMID 24035500 DOI: 10.1016/J.Molcel.2013.08.019  0.416
2013 Loewith RJ. Growth control: function follows form. Current Biology. 23. PMID 23885874 DOI: 10.1016/J.Cub.2013.05.048  0.368
2012 Berchtold D, Piccolis M, Chiaruttini N, Riezman I, Riezman H, Roux A, Walther TC, Loewith R. Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nature Cell Biology. 14: 542-7. PMID 22504275 DOI: 10.1038/Ncb2480  0.34
2012 Chen J, Young SM, Allen C, Seeber A, Péli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao T, Golden JE, Strouse JJ, Carter MB, Kang H, Bologa CG, Foutz TD, ... ... Loewith RJ, et al. Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry. Acs Chemical Biology. 7: 715-22. PMID 22260433 DOI: 10.1021/Cb200452R  0.376
2011 Loewith R, Hall MN. Target of rapamycin (TOR) in nutrient signaling and growth control Genetics. 189: 1177-1201. PMID 22174183 DOI: 10.1534/Genetics.111.133363  0.409
2011 Kawai S, Urban J, Piccolis M, Panchaud N, Virgilio CD, Loewith RJ. Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae. Eukaryotic Cell. 10: 1367-1369. PMID 21841122 DOI: 10.1128/Ec.05157-11  0.348
2011 Huber A, French SL, Tekotte H, Yerlikaya S, Stahl M, Perepelkina MP, Tyers M, Rougemont J, Beyer AL, Loewith R. Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L. The Embo Journal. 30: 3052-64. PMID 21730963 DOI: 10.1038/Emboj.2011.221  0.471
2011 Loewith RJ. A brief history of TOR. Biochemical Society Transactions. 39: 437-442. PMID 21428915 DOI: 10.1042/Bst0390437  0.399
2010 Bodenmiller B, Wanka S, Kraft C, Urban J, Campbell D, Pedrioli PG, Gerrits B, Picotti P, Lam H, Vitek O, Brusniak MY, Roschitzki B, Zhang C, Shokat KM, Schlapbach R, ... ... Loewith R, et al. Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Science Signaling. 3: rs4. PMID 21177495 DOI: 10.1126/Scisignal.2001182  0.423
2010 Loewith R. TORC1 Signaling in Budding Yeast The Enzymes. 27: 147-175. DOI: 10.1016/S1874-6047(10)27009-9  0.504
2009 Binda M, Péli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R, De Virgilio C. The Vam6 GEF controls TORC1 by activating the EGO complex. Molecular Cell. 35: 563-73. PMID 19748353 DOI: 10.1016/J.Molcel.2009.06.033  0.425
2009 Huber A, Bodenmiller B, Uotila A, Stahl M, Wanka S, Gerrits B, Aebersold R, Loewith R. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes & Development. 23: 1929-43. PMID 19684113 DOI: 10.1101/Gad.532109  0.497
2009 Lempiäinen H, Uotila A, Urban J, Dohnal I, Ammerer G, Loewith R, Shore D. Sfp1 Interaction with TORC1 and Mrs6 Reveals Feedback Regulation on TOR Signaling Molecular Cell. 33: 704-716. PMID 19328065 DOI: 10.1016/J.Molcel.2009.01.034  0.511
2009 Guan XL, Souza CM, Pichler H, Dewhurst G, Schaad O, Kajiwara K, Wakabayashi H, Ivanova T, Castillon GA, Piccolis M, Abe F, Loewith R, Funato K, Wenk MR, Riezman H. Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Molecular Biology of the Cell. 20: 2083-95. PMID 19225153 DOI: 10.1091/Mbc.E08-11-1126  0.38
2009 Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. Plos Biology. 7: e38. PMID 19209957 DOI: 10.1371/Journal.Pbio.1000038  0.447
2008 Hosiner D, Lempiainen H, Reiter W, Urban J, Loewith RJ, Ammerer G, Schweyen R, Shore DM, Schüller C. Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response. Molecular Biology of the Cell. 20: 1048-1057. PMID 19073887 DOI: 10.1091/Mbc.E08-04-0438  0.444
2008 Wanke V, Cameroni E, Uotila A, Piccolis M, Urban J, Loewith R, Virgilio CD. Caffeine extends yeast lifespan by targeting TORC1 Molecular Microbiology. 69: 277-285. PMID 18513215 DOI: 10.1111/J.1365-2958.2008.06292.X  0.441
2007 Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D, Deloche O, Wanke V, Anrather D, Ammerer G, Riezman H, Broach JR, De Virgilio C, Hall MN, Loewith R. Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Molecular Cell. 26: 663-74. PMID 17560372 DOI: 10.1016/J.Molcel.2007.04.020  0.459
2006 Virgilio CD, Loewith R. Cell growth control: little eukaryotes make big contributions. Oncogene. 25: 6392-6415. PMID 17041625 DOI: 10.1038/Sj.Onc.1209884  0.481
2006 Mulet JM, Martin DE, Loewith R, Hall MN. Mutual antagonism of target of rapamycin and calcineurin signaling Journal of Biological Chemistry. 281: 33000-33007. PMID 16959779 DOI: 10.1074/Jbc.M604244200  0.425
2006 Virgilio CD, Loewith RJ. The TOR signalling network from yeast to man The International Journal of Biochemistry & Cell Biology. 38: 1476-1481. PMID 16647875 DOI: 10.1016/J.Biocel.2006.02.013  0.439
2006 Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 125: 733-47. PMID 16647110 DOI: 10.1016/J.Cell.2006.03.035  0.313
2006 Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism Cell. 124: 471-484. PMID 16469695 DOI: 10.1016/J.Cell.2006.01.016  0.41
2005 Kamada Y, Fujioka Y, Suzuki NN, Inagaki F, Wullschleger S, Loewith R, Hall MN, Ohsumi Y. Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Molecular and Cellular Biology. 25: 7239-7248. PMID 16055732 DOI: 10.1128/Mcb.25.16.7239-7248.2005  0.501
2005 Wullschleger S, Loewith R, Oppliger W, Hall MN. Molecular organization of target of rapamycin complex 2 Journal of Biological Chemistry. 280: 30697-30704. PMID 16002396 DOI: 10.1074/Jbc.M505553200  0.519
2004 Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nature Cell Biology. 6: 1122-8. PMID 15467718 DOI: 10.1038/Ncb1183  0.494
2004 Audhya A, Loewith R, Parsons AB, Gao L, Tabuchi M, Zhou H, Boone C, Hall MN, Emr SD. Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. The Embo Journal. 23: 3747-57. PMID 15372071 DOI: 10.1038/Sj.Emboj.7600384  0.436
2004 Loewith R, Hall MN. TOR signaling in yeast : temporal and spatial control of cell growth Cold Spring Harbor Monograph Archive. 42: 139-165. DOI: 10.1101/087969672.42.139  0.325
2002 Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control Molecular Cell. 10: 457-468. PMID 12408816 DOI: 10.1016/S1097-2765(02)00636-6  0.481
2002 Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K. Human ING1 proteins differentially regulate histone acetylation. The Journal of Biological Chemistry. 277: 29832-9. PMID 12015309 DOI: 10.1074/Jbc.M200197200  0.683
2001 Loewith R, Smith JS, Meijer M, Williams TJ, Bachman N, Boeke JD, Young D. Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 276: 24068-74. PMID 11306585 DOI: 10.1074/Jbc.M102176200  0.688
2000 Loewith R, Meijer M, Lees-Miller SP, Riabowol K, Young D. Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Molecular and Cellular Biology. 20: 3807-16. PMID 10805724 DOI: 10.1128/Mcb.20.11.3807-3816.2000  0.704
1996 Hubberstey A, Yu G, Loewith R, Lakusta C, Young D. Mammalian CAP interacts with CAP, CAP2, and actin Journal of Cellular Biochemistry. 61: 459-466. PMID 8761950 DOI: 10.1002/(Sici)1097-4644(19960601)61:3<459::Aid-Jcb13>3.0.Co;2-E  0.659
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