| Year |
Citation |
Score |
| 2023 |
Chater RC, Quinn AS, Wilson K, Frangos ZJ, Sutton P, Jayakumar S, Cioffi CL, O'Mara ML, Vandenberg RJ. The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites. Journal of Neurochemistry. PMID 38131125 DOI: 10.1111/jnc.16028 |
0.369 |
|
| 2023 |
Gallagher CI, Frangos ZJ, Sheipouri D, Shimmon S, Duman MN, Jayakumar S, Cioffi CL, Rawling T, Vandenberg RJ. Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2. Acs Chemical Neuroscience. PMID 37466545 DOI: 10.1021/acschemneuro.3c00167 |
0.364 |
|
| 2023 |
Frangos ZJ, Wilson KA, Aitken HM, Cantwell Chater R, Vandenberg RJ, O'Mara ML. Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2. Life Science Alliance. 6. PMID 36690444 DOI: 10.26508/lsa.202201708 |
0.436 |
|
| 2022 |
Wilson BS, Peiser-Oliver J, Gillis A, Evans S, Alamein C, Mostyn SN, Shimmon S, Rawling T, Christie MJ, Vandenberg RJ, Mohammadi SA. . The Journal of Pharmacology and Experimental Therapeutics. PMID 35779948 DOI: 10.1124/jpet.122.001265 |
0.77 |
|
| 2021 |
Harvey RJ, Vandenberg RJ. Glycine Transporters and Receptors as Targets for Analgesics. Biomolecules. 11. PMID 34827674 DOI: 10.3390/biom11111676 |
0.402 |
|
| 2021 |
Frangos ZJ, Cantwell Chater RP, Vandenberg RJ. Glycine Transporter 2: Mechanism and Allosteric Modulation. Frontiers in Molecular Biosciences. 8: 734427. PMID 34805268 DOI: 10.3389/fmolb.2021.734427 |
0.435 |
|
| 2021 |
Chen I, Pant S, Wu Q, Cater RJ, Sobti M, Vandenberg RJ, Stewart AG, Tajkhorshid E, Font J, Ryan RM. Glutamate transporters have a chloride channel with two hydrophobic gates. Nature. PMID 33597752 DOI: 10.1038/s41586-021-03240-9 |
0.676 |
|
| 2021 |
Wilson KA, Mostyn SN, Frangos ZJ, Shimmon S, Rawling T, Vandenberg RJ, O'Mara ML. The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity. The Journal of Biological Chemistry. 100282. PMID 33450225 DOI: 10.1016/j.jbc.2021.100282 |
0.805 |
|
| 2020 |
Sheipouri D, Gallagher CI, Shimmon S, Rawling T, Vandenberg RJ. A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors. Biomolecules. 10. PMID 33266066 DOI: 10.3390/biom10121618 |
0.38 |
|
| 2020 |
Aubrey KR, Sheipouri D, Balle T, Vandenberg RJ, Otsu Y. Glutamate, AP5 and NMDA do not directly modulate glycine receptors. Molecular Pharmacology. PMID 33051383 DOI: 10.1124/molpharm.120.000127 |
0.744 |
|
| 2020 |
Gallagher CI, Sheipouri D, Shimmon S, Rawling T, Vandenberg RJ. Identification of N-acyl amino acids that are positive allosteric modulators of glycine receptors. Biochemical Pharmacology. 114117. PMID 32579961 DOI: 10.1016/J.Bcp.2020.114117 |
0.381 |
|
| 2020 |
Mostyn SN, Sarker S, Muthuraman P, Raja A, Shimmon S, Rawling T, Cioffi CL, Vandenberg RJ. A photoswitchable ORG25543 congener enables optical control of glycine transporter 2. Acs Chemical Neuroscience. PMID 32191428 DOI: 10.1021/Acschemneuro.9B00655 |
0.802 |
|
| 2020 |
Freidman N, Chen I, Wu Q, Briot C, Holst J, Font J, Vandenberg R, Ryan R. Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer. Neurochemical Research. PMID 31981058 DOI: 10.1007/S11064-019-02934-X |
0.691 |
|
| 2019 |
Mostyn SN, Wilson KA, Schumann-Gillett A, Frangos ZJ, Shimmon S, Rawling T, Ryan RM, O'Mara ML, Vandenberg RJ. Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics. Elife. 8. PMID 31621581 DOI: 10.7554/Elife.47150 |
0.824 |
|
| 2019 |
Mostyn SN, Rawling T, Mohammadi S, Shimmon S, Frangos ZJ, Sarker S, Yousuf A, Vetter I, Ryan RM, Christie MJ, Vandenberg RJ. Development of an N-acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain. Journal of Medicinal Chemistry. PMID 30714733 DOI: 10.1021/Acs.Jmedchem.8B01775 |
0.787 |
|
| 2019 |
Vandenberg RJ, Meyerson J. Decision letter: Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation Elife. DOI: 10.7554/Elife.48120.026 |
0.388 |
|
| 2019 |
Mostyn SN, Wilson KA, Schumann-Gillett A, Frangos ZJ, Shimmon S, Rawling T, Ryan RM, O'Mara ML, Vandenberg RJ. Author response: Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics Elife. DOI: 10.7554/Elife.47150.029 |
0.8 |
|
| 2018 |
Winters BL, Rawling T, Vandenberg RJ, Christie MJ, Bhola RF, Imlach WL. Activity of novel lipid glycine transporter inhibitors on synaptic signalling in the dorsal horn of the spinal cord. British Journal of Pharmacology. PMID 29500820 DOI: 10.1111/Bph.14189 |
0.453 |
|
| 2018 |
Scopelliti AJ, Font J, Vandenberg RJ, Boudker O, Ryan RM. Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5. Nature Communications. 9: 38. PMID 29295993 DOI: 10.1038/S41467-017-02444-W |
0.675 |
|
| 2017 |
Carland JE, Thomas M, Mostyn SN, Subramanian N, O'Mara ML, Ryan RM, Vandenberg RJ. Molecular Determinants for Substrate Interactions with the Glycine Transporter GlyT2. Acs Chemical Neuroscience. PMID 29120604 DOI: 10.1021/Acschemneuro.7B00407 |
0.825 |
|
| 2017 |
Mostyn SN, Carland JE, Shimmon S, Ryan RM, Rawling T, Vandenberg RJ. Synthesis and Characterization of Novel Acyl-Glycine Inhibitors of GlyT2. Acs Chemical Neuroscience. PMID 28574249 DOI: 10.1021/Acschemneuro.7B00105 |
0.822 |
|
| 2016 |
Krycer JR, Fazakerley DJ, Cater RJ, Thomas K, Naghiloo S, Burchfield JG, Humphrey SJ, Vandenberg RJ, Ryan RM, James DE. The amino acid transporter SLC1A3 is plasma membrane-localised in adipocytes and its activity is insensitive to insulin. Febs Letters. PMID 28032905 DOI: 10.1002/1873-3468.12549 |
0.567 |
|
| 2016 |
McIlwain BC, Vandenberg RJ, Ryan RM. Characterization of the Inward- and Outward-Facing Substrate Binding Sites of the Prokaryotic Aspartate Transporter, GltPh. Biochemistry. 55: 6801-6810. PMID 27951659 DOI: 10.1021/Acs.Biochem.6B00795 |
0.71 |
|
| 2016 |
Vandenberg RJ, Ryan R, Broer S. Brain transporters: From genes and genetic disorders to function and drug discovery. Neurochemistry International. 98: 1-3. PMID 27475459 DOI: 10.1016/J.Neuint.2016.07.005 |
0.575 |
|
| 2016 |
Subramanian N, Scopelliti AJ, Carland JE, Ryan RM, O'Mara ML, Vandenberg RJ. Correction: Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2. Plos One. 11: e0159896. PMID 27434127 DOI: 10.1371/Journal.Pone.0159896 |
0.619 |
|
| 2016 |
Subramanian N, Scopelitti AJ, Carland JE, Ryan RM, O'Mara ML, Vandenberg RJ. Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2. Plos One. 11: e0157583. PMID 27337045 DOI: 10.1371/Journal.Pone.0157583 |
0.673 |
|
| 2016 |
Cater RJ, Vandenberg RJ, Ryan RM. Tuning the ion selectivity of glutamate transporter-associated uncoupled conductances. The Journal of General Physiology. PMID 27296367 DOI: 10.1085/Jgp.201511556 |
0.72 |
|
| 2016 |
Ryan RM, Vandenberg RJ. Elevating the alternating-access model. Nature Structural & Molecular Biology. 23: 187-9. PMID 26931415 DOI: 10.1038/Nsmb.3179 |
0.573 |
|
| 2015 |
Vandenberg RJ, Mostyn SN, Carland JE, Ryan RM. Glycine Transporter2 Inhibitors: Getting the balance right. Neurochemistry International. PMID 26723543 DOI: 10.1016/J.Neuint.2015.12.007 |
0.808 |
|
| 2015 |
Cater RJ, Ryan RM, Vandenberg RJ. The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter. Neurochemical Research. PMID 26303507 DOI: 10.1007/S11064-015-1699-6 |
0.703 |
|
| 2015 |
McIlwain BC, Vandenberg RJ, Ryan RM. Transport rates of a glutamate transporter homologue are influenced by the lipid bilayer. The Journal of Biological Chemistry. 290: 9780-8. PMID 25713135 DOI: 10.1074/Jbc.M114.630590 |
0.682 |
|
| 2014 |
Cater RJ, Vandenberg RJ, Ryan RM. The domain interface of the human glutamate transporter EAAT1 mediates chloride permeation. Biophysical Journal. 107: 621-9. PMID 25099801 DOI: 10.1016/J.Bpj.2014.05.046 |
0.706 |
|
| 2014 |
Vandenberg RJ, Ryan RM, Carland JE, Imlach WL, Christie MJ. Glycine transport inhibitors for the treatment of pain. Trends in Pharmacological Sciences. 35: 423-30. PMID 24962068 DOI: 10.1016/J.Tips.2014.05.006 |
0.629 |
|
| 2014 |
Scopelliti AJ, Heinzelmann G, Kuyucak S, Ryan RM, Vandenberg RJ. Na+ interactions with the neutral amino acid transporter ASCT1. The Journal of Biological Chemistry. 289: 17468-79. PMID 24808181 DOI: 10.1074/Jbc.M114.565242 |
0.668 |
|
| 2014 |
Carland JE, Handford CA, Ryan RM, Vandenberg RJ. Lipid inhibitors of high affinity glycine transporters: identification of a novel class of analgesics. Neurochemistry International. 73: 211-6. PMID 24036283 DOI: 10.1016/J.Neuint.2013.08.012 |
0.679 |
|
| 2013 |
Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, ... ... Vandenberg RJ, et al. The Concise Guide to PHARMACOLOGY 2013/14: overview. British Journal of Pharmacology. 170: 1449-58. PMID 24528237 DOI: 10.1111/Bph.12444 |
0.494 |
|
| 2013 |
Vandenberg RJ, Ryan RM. Mechanisms of glutamate transport. Physiological Reviews. 93: 1621-57. PMID 24137018 DOI: 10.1152/Physrev.00007.2013 |
0.674 |
|
| 2013 |
Scopelliti AJ, Ryan RM, Vandenberg RJ. Molecular determinants for functional differences between alanine-serine-cysteine transporter 1 and other glutamate transporter family members. The Journal of Biological Chemistry. 288: 8250-7. PMID 23393130 DOI: 10.1074/Jbc.M112.441022 |
0.704 |
|
| 2013 |
Carland JE, Mansfield RE, Ryan RM, Vandenberg RJ. Oleoyl-L-carnitine inhibits glycine transport by GlyT2. British Journal of Pharmacology. 168: 891-902. PMID 22978602 DOI: 10.1111/J.1476-5381.2012.02213.X |
0.687 |
|
| 2012 |
Bastug T, Heinzelmann G, Kuyucak S, Salim M, Vandenberg RJ, Ryan RM. Position of the third Na+ site in the aspartate transporter GltPh and the human glutamate transporter, EAAT1. Plos One. 7: e33058. PMID 22427946 DOI: 10.1371/Journal.Pone.0033058 |
0.689 |
|
| 2011 |
Vandenberg RJ, Handford CA, Campbell EM, Ryan RM, Yool AJ. Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1. The Biochemical Journal. 439: 333-40. PMID 21732909 DOI: 10.1042/Bj20110905 |
0.709 |
|
| 2011 |
Bailey CG, Ryan RM, Thoeng AD, Ng C, King K, Vanslambrouck JM, Auray-Blais C, Vandenberg RJ, Bröer S, Rasko JE. Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. The Journal of Clinical Investigation. 121: 446-53. PMID 21123949 DOI: 10.1172/Jci44474 |
0.666 |
|
| 2011 |
Scott HA, Gebhardt FM, Mitrovic AD, Vandenberg RJ, Dodd PR. Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease. Neurobiology of Aging. 32: 553.e1-11. PMID 20416976 DOI: 10.1016/J.Neurobiolaging.2010.03.008 |
0.457 |
|
| 2010 |
Jeong HJ, Vandenberg RJ, Vaughan CW. N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn. British Journal of Pharmacology. 161: 925-35. PMID 20860669 DOI: 10.1111/J.1476-5381.2010.00935.X |
0.369 |
|
| 2010 |
Gebhardt FM, Mitrovic AD, Gilbert DF, Vandenberg RJ, Lynch JW, Dodd PR. Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2. The Journal of Biological Chemistry. 285: 31313-24. PMID 20688910 DOI: 10.1074/Jbc.M110.153494 |
0.492 |
|
| 2010 |
Connor M, Vaughan CW, Vandenberg RJ. N-acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets. British Journal of Pharmacology. 160: 1857-71. PMID 20649585 DOI: 10.1111/J.1476-5381.2010.00862.X |
0.45 |
|
| 2010 |
Ryan RM, Kortt NC, Sirivanta T, Vandenberg RJ. The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1. Journal of Neurochemistry. 114: 565-75. PMID 20477940 DOI: 10.1111/J.1471-4159.2010.06796.X |
0.695 |
|
| 2010 |
McKinzie AA, Ryan RM, Vandenberg RJ. Site-directed mutagenesis in the study of membrane transporters. Methods in Molecular Biology (Clifton, N.J.). 637: 277-93. PMID 20419441 DOI: 10.1007/978-1-60761-700-6_15 |
0.604 |
|
| 2009 |
Edington AR, McKinzie AA, Reynolds AJ, Kassiou M, Ryan RM, Vandenberg RJ. Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. The Journal of Biological Chemistry. 284: 36424-30. PMID 19875446 DOI: 10.1074/Jbc.M109.017509 |
0.692 |
|
| 2009 |
Habjan S, Vandenberg RJ. Modulation of glutamate and glycine transporters by niflumic, flufenamic and mefenamic acids. Neurochemical Research. 34: 1738-47. PMID 19444608 DOI: 10.1007/S11064-009-9983-Y |
0.464 |
|
| 2009 |
Liu X, Mitrovic AD, Vandenberg RJ. Glycine transporter 1 associates with cholesterol-rich membrane raft microdomains. Biochemical and Biophysical Research Communications. 384: 530-4. PMID 19427831 DOI: 10.1016/J.Bbrc.2009.05.014 |
0.406 |
|
| 2009 |
Huang S, Ryan RM, Vandenberg RJ. The role of cation binding in determining substrate selectivity of glutamate transporters. The Journal of Biological Chemistry. 284: 4510-5. PMID 19074430 DOI: 10.1074/Jbc.M808495200 |
0.723 |
|
| 2008 |
Yang Z, Aubrey KR, Alroy I, Harvey RJ, Vandenberg RJ, Lynch JW. Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology. 76: 1014-23. PMID 18755158 DOI: 10.1016/J.Bcp.2008.07.037 |
0.71 |
|
| 2008 |
Vandenberg RJ, Huang S, Ryan RM. Slips, leaks and channels in glutamate transporters. Channels (Austin, Tex.). 2: 51-8. PMID 18690049 DOI: 10.4161/Chan.2.1.6047 |
0.689 |
|
| 2007 |
Huang S, Vandenberg RJ. Mutations in transmembrane domains 5 and 7 of the human excitatory amino acid transporter 1 affect the substrate-activated anion channel. Biochemistry. 46: 9685-92. PMID 17676873 DOI: 10.1021/Bi700647F |
0.56 |
|
| 2007 |
Vandenberg RJ, Shaddick K, Ju P. Molecular basis for substrate discrimination by glycine transporters. The Journal of Biological Chemistry. 282: 14447-53. PMID 17383967 DOI: 10.1074/Jbc.M609158200 |
0.559 |
|
| 2006 |
Wiles AL, Pearlman RJ, Rosvall M, Aubrey KR, Vandenberg RJ. N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. Journal of Neurochemistry. 99: 781-6. PMID 16899062 DOI: 10.1111/J.1471-4159.2006.04107.X |
0.774 |
|
| 2006 |
Vandenberg RJ. Mutational analysis of glutamate transporters. Handbook of Experimental Pharmacology. 113-35. PMID 16722233 DOI: 10.1007/3-540-29784-7_6 |
0.562 |
|
| 2005 |
Aubrey KR, Vandenberg RJ, Clements JD. Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. Biophysical Journal. 89: 1657-68. PMID 15951392 DOI: 10.1529/Biophysj.105.061572 |
0.806 |
|
| 2005 |
Vandenberg RJ, Ryan RM. How and why are channels in transporters? Science's Stke : Signal Transduction Knowledge Environment. 2005: pe17. PMID 15840837 DOI: 10.1126/Stke.2802005Pe17 |
0.64 |
|
| 2005 |
Ryan RM, Vandenberg RJ. A channel in a transporter. Clinical and Experimental Pharmacology & Physiology. 32: 1-6. PMID 15730426 DOI: 10.1111/J.1440-1681.2005.04164.X |
0.703 |
|
| 2004 |
Vandenberg RJ, Ju P, Aubrey KR, Ryan RM, Mitrovic AD. Allosteric modulation of neurotransmitter transporters at excitatory synapses. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 23: 1-11. PMID 15324920 DOI: 10.1016/J.Ejps.2004.05.006 |
0.835 |
|
| 2004 |
Liu L, Markus I, Vandenberg RJ, Neilan BA, Murray M, Burcher E. Molecular identification and characterization of three isoforms of tachykinin NK(1)-like receptors in the cane toad Bufo marinus. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 287: R575-85. PMID 15155274 DOI: 10.1152/Ajpregu.00051.2004 |
0.305 |
|
| 2004 |
Ju P, Aubrey KR, Vandenberg RJ. Zn2+ inhibits glycine transport by glycine transporter subtype 1b. The Journal of Biological Chemistry. 279: 22983-91. PMID 15031290 DOI: 10.1074/Jbc.M312484200 |
0.822 |
|
| 2004 |
Ryan RM, Mitrovic AD, Vandenberg RJ. The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway. The Journal of Biological Chemistry. 279: 20742-51. PMID 14982939 DOI: 10.1074/Jbc.M304433200 |
0.706 |
|
| 2003 |
Ryan RM, Mitrovic AD, Vandenberg RJ. Site-directed mutagenesis in the study of membrane transporters. Methods in Molecular Biology (Clifton, N.J.). 227: 97-108. PMID 12824646 DOI: 10.1385/1-59259-387-9:97 |
0.645 |
|
| 2003 |
Pearlman RJ, Aubrey KR, Vandenberg RJ. Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. Journal of Neurochemistry. 84: 592-601. PMID 12558979 DOI: 10.1046/J.1471-4159.2003.01549.X |
0.821 |
|
| 2002 |
Moussa Cel-H, Mitrovic AD, Vandenberg RJ, Provis T, Rae C, Bubb WA, Balcar VJ. Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochemical Research. 27: 27-35. PMID 11926273 DOI: 10.1023/A:1014842303583 |
0.381 |
|
| 2002 |
Ryan RM, Vandenberg RJ. Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1. The Journal of Biological Chemistry. 277: 13494-500. PMID 11815608 DOI: 10.1074/Jbc.M109970200 |
0.72 |
|
| 2001 |
Vandenberg RJ, Aubrey KR. Glycine transport inhibitors as potential antipsychotic drugs. Expert Opinion On Therapeutic Targets. 5: 507-518. PMID 12540263 DOI: 10.1517/14728222.5.4.507 |
0.78 |
|
| 2001 |
Aubrey KR, Vandenberg RJ. N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology. 134: 1429-36. PMID 11724748 DOI: 10.1038/Sj.Bjp.0704381 |
0.832 |
|
| 2001 |
Poulsen MV, Vandenberg RJ. Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4. The Journal of Physiology. 534: 159-67. PMID 11432999 DOI: 10.1111/J.1469-7793.2001.00159.X |
0.469 |
|
| 2001 |
Mitrovic AD, Plesko F, Vandenberg RJ. Zn(2+) inhibits the anion conductance of the glutamate transporter EEAT4. The Journal of Biological Chemistry. 276: 26071-6. PMID 11352900 DOI: 10.1074/Jbc.M011318200 |
0.547 |
|
| 2001 |
Vandenberg RJ, Aubrey KR. Central and peripheral nervous system: Glycine transport inhibitors as potential antipsychotic drugs Expert Opinion On Therapeutic Targets. 5: 507-518. |
0.778 |
|
| 2000 |
Aubrey KR, Mitrovic AD, Vandenberg RJ. Molecular basis for proton regulation of glycine transport by glycine transporter subtype 1b. Molecular Pharmacology. 58: 129-35. PMID 10860934 DOI: 10.1124/Mol.58.1.129 |
0.825 |
|
| 1999 |
Johnston GAR, Chebib M, Duke RK, Mewett KN, Mitrovic AD, Vandenberg RJ. Medicinal chemistry and molecular pharmacology of GABA receptors and glutamate transporters - Complementary structure-activity relationships Drug Development Research. 46: 255-260. DOI: 10.1002/(Sici)1098-2299(199903/04)46:3/4<255::Aid-Ddr10>3.0.Co;2-S |
0.466 |
|
| 1998 |
Vandenberg RJ. Molecular pharmacology and physiology of glutamate transporters in the central nervous system. Clinical and Experimental Pharmacology & Physiology. 25: 393-400. PMID 9673812 DOI: 10.1111/J.1440-1681.1998.Tb02221.X |
0.571 |
|
| 1998 |
Vandenberg RJ, Mitrovic AD, Johnston GA. Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions. Molecular Pharmacology. 54: 189-96. PMID 9658205 DOI: 10.1124/Mol.54.1.189 |
0.573 |
|
| 1998 |
Mitrovic AD, Amara SG, Johnston GA, Vandenberg RJ. Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. The Journal of Biological Chemistry. 273: 14698-706. PMID 9614067 DOI: 10.1074/Jbc.273.24.14698 |
0.729 |
|
| 1998 |
Vandenberg RJ, Mitrovic AD, Johnston GA. Serine-O-sulphate transport by the human glutamate transporter, EAAT2. British Journal of Pharmacology. 123: 1593-600. PMID 9605566 DOI: 10.1038/Sj.Bjp.0701776 |
0.539 |
|
| 1997 |
Chebib M, Vandenberg RJ, Johnston GA. Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. British Journal of Pharmacology. 122: 1551-60. PMID 9422798 DOI: 10.1038/Sj.Bjp.0701533 |
0.334 |
|
| 1997 |
Vandenberg RJ, Mitrovic AD, Chebib M, Balcar VJ, Johnston GA. Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Molecular Pharmacology. 51: 809-15. PMID 9145919 DOI: 10.1124/Mol.51.5.809 |
0.528 |
|
| 1995 |
Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature. 375: 599-603. PMID 7791878 DOI: 10.1038/375599A0 |
0.705 |
|
| 1995 |
Vandenberg RJ, Arriza JL, Amara SG, Kavanaugh MP. Constitutive ion fluxes and substrate binding domains of human glutamate transporters. The Journal of Biological Chemistry. 270: 17668-71. PMID 7629063 DOI: 10.1074/Jbc.270.30.17668 |
0.723 |
|
| 1995 |
Rajendra S, Vandenberg RJ, Pierce KD, Cunningham AM, French PW, Barry PH, Schofield PR. The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element. The Embo Journal. 14: 2987-98. PMID 7621814 DOI: 10.1002/J.1460-2075.1995.Tb07301.X |
0.307 |
|
| 1992 |
Vandenberg RJ, Handford CA, Schofield PR. Distinct agonist- and antagonist-binding sites on the glycine receptor. Neuron. 9: 491-6. PMID 1326295 DOI: 10.1016/0896-6273(92)90186-H |
0.329 |
|
| 1992 |
Vandenberg RJ, French CR, Barry PH, Shine J, Schofield PR. Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site. Proceedings of the National Academy of Sciences of the United States of America. 89: 1765-9. PMID 1311851 DOI: 10.1073/Pnas.89.5.1765 |
0.324 |
|
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