| Year |
Citation |
Score |
| 2023 |
Elshazly AM, Sinanian MM, Neely V, Chakraborty E, Alshehri MA, McGrath MK, Harada H, Schoenlein PV, Gewirtz DA. BRD4 Inhibition as a Strategy to Prolong the Response to Standard of Care in Estrogen Receptor-Positive Breast Cancer. Cancers. 15. PMID 37627092 DOI: 10.3390/cancers15164066 |
0.566 |
|
| 2022 |
Hagan ML, Mander S, Joseph C, McGrath M, Barrett A, Lewis A, Hill WD, Browning D, McGee-Lawrence ME, Cai H, Liu K, Barrett JT, Gewirtz DA, Thangaraju M, Schoenlein PV. Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen‑induced BimEL dependent apoptosis in ER breast cancer cells. International Journal of Oncology. 62. PMID 36524361 DOI: 10.3892/ijo.2022.5468 |
0.621 |
|
| 2022 |
Finnegan RM, Elshazly AM, Schoenlein PV, Gewirtz DA. Therapeutic Potential for Targeting Autophagy in ER+ Breast Cancer. Cancers. 14. PMID 36077830 DOI: 10.3390/cancers14174289 |
0.505 |
|
| 2020 |
Herrington K, Joseph C, Abdulmoneim S, Lewis A, Cai J, Youngblood H, Liu Y, Schoenlein P. Abstract 1231: Targeting JNK1/2 induces a potent cytostatic response in estrogen receptor expressing breast cancer cells, with induction of autophagy and senescence as measurable outcomes Cancer Research. 80: 1231-1231. DOI: 10.1158/1538-7445.Am2020-1231 |
0.677 |
|
| 2019 |
Meghil MM, Tawfik OK, Elashiry M, Rajendran M, Arce RM, Fulton DJ, Schoenlein PV, Cutler CW. Disruption of Immune Homeostasis in Human Dendritic Cells via Regulation of Autophagy and Apoptosis by . Frontiers in Immunology. 10: 2286. PMID 31608069 DOI: 10.3389/Fimmu.2019.02286 |
0.422 |
|
| 2017 |
Munagala R, Joseph C, Liu A, Liu K, Thangaraju M, Schoenlein PV. Abstract 3318: A critical role for c-Jun N-terminal kinase in autophagy and cell survival of breast cancer cells Cancer Research. 77: 3318-3318. DOI: 10.1158/1538-7445.Am2017-3318 |
0.715 |
|
| 2016 |
Liu F, Li X, Lu C, Bai A, Bielawski J, Bielawska A, Marshall B, Schoenlein PV, Lebedyeva IO, Liu K. Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells. Oncotarget. PMID 27880732 DOI: 10.18632/Oncotarget.13438 |
0.55 |
|
| 2016 |
Conger J, Manning M, Anosike K, Elsherbini A, Ware B, Bass E, Thangaraju M, Browning D, Schoenlein PV. Abstract 4672: Targeting MEK/MAPK1/2in vivoto eradicate antiestrogen resistance Cancer Research. 76: 4672-4672. DOI: 10.1158/1538-7445.Am2016-4672 |
0.697 |
|
| 2015 |
Manning M, Takhar S, Periyasamy-Thandavan S, Cheng M, Barrett T, Hill W, Browning D, Thangaraju M, McGee-Lawrence M, Schoenlein PV. Abstract 1005: Dual targeting of MEK/MAPK1/2 and pro-survival autophagy to optimize antiestrogen treatment toward the eradication of antiestrogen resistant breast cancer Cancer Research. 75: 1005-1005. DOI: 10.1158/1538-7445.Am2015-1005 |
0.684 |
|
| 2014 |
Takhar S, Manning M, Eason A, Dix M, Periyasamy-Thandavan S, Padi R, Bieberich E, Hill W, Browning D, Ganapathy V, Thangaraju M, Schoenlein PV. Abstract B50: MEK inhibitors mount a two-pronged attack to kill estrogen receptor positive (ER+) breast cancer cells undergoing hormonal therapy: Attenuated autophagy and induction of apoptosis Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B50 |
0.689 |
|
| 2013 |
Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Srinivas SR, Babu E, Hawthorn L, Schoenlein PV, Boettger T, Smith SB, Prasad PD, Ganapathy V, Thangaraju M. Molecular mechanism of SLC5A8 inactivation in breast cancer. Molecular and Cellular Biology. 33: 3920-35. PMID 23918800 DOI: 10.1128/Mcb.01702-12 |
0.429 |
|
| 2013 |
Berning A, Eason A, Gilley N, Takhar S, ElShafey S, Thangaraju M, Schoenlein PV. Abstract 1725: HDAC inhibition induces Bim expression and apoptosis in breast cancer cells undergoing paclitaxel or antiestrogen treatment. Cancer Research. 73: 1725-1725. DOI: 10.1158/1538-7445.Am2013-1725 |
0.719 |
|
| 2012 |
Periyasamy-Thandavan S, Takhar S, Singer A, Dohn MR, Jackson WH, Welborn AE, LeRoith D, Marrero M, Thangaraju M, Huang S, Schoenlein PV. Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim. Breast Cancer Research : Bcr. 14: R52. PMID 22429491 DOI: 10.1186/Bcr3153 |
0.643 |
|
| 2011 |
Elangovan S, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP, Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V, Thangaraju M. SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer. Cancer Research. 71: 6654-64. PMID 21920899 DOI: 10.1158/0008-5472.Can-11-1446 |
0.651 |
|
| 2011 |
Karunakaran S, Ramachandran S, Coothankandaswamy V, Elangovan S, Babu E, Periyasamy-Thandavan S, Gurav A, Gnanaprakasam JP, Singh N, Schoenlein PV, Prasad PD, Thangaraju M, Ganapathy V. SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. The Journal of Biological Chemistry. 286: 31830-8. PMID 21771784 DOI: 10.1074/Jbc.M111.229518 |
0.599 |
|
| 2011 |
Ganapathy V, Karunakaran S, Ramachandran S, Babu E, Elangovan S, Periaswamy-Thandavan S, Schoenlein PV, Gurav A, Singh N, Prasad PD, Thangaraju M. Abstract 4459: a-Methyltryptophan (a-MT) inhibits estrogen receptor (ER)-positive breast cancer growth through blockade of SLC6A14 Cancer Research. 71: 4459-4459. DOI: 10.1158/1538-7445.Am2011-4459 |
0.625 |
|
| 2011 |
Rowland A, Periyasamy-Thandavan S, Takhar S, Barrett JR, Bieberich E, Schoenlein P. Abstract 3783: Molecular targeting of sphingosine kinase increases the efficacy of hormonal therapy for breast cancer by blocking the catabolic function of autophagy Cancer Research. 71: 3783-3783. DOI: 10.1158/1538-7445.Am2011-3783 |
0.649 |
|
| 2011 |
Takhar S, Periyasamy-Thandavan S, Jackson WH, Huang S, Schoenlein P. Abstract 2: IGF-1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER + breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim Cancer Research. 71: 2-2. DOI: 10.1158/1538-7445.Am2011-2 |
0.693 |
|
| 2010 |
Periyasamy-Thandavan S, Jackson WH, Samaddar JS, Erickson B, Barrett JR, Raney L, Gopal E, Ganapathy V, Hill WD, Bhalla KN, Schoenlein PV. Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells. Autophagy. 6: 19-35. PMID 20110775 DOI: 10.4161/Auto.6.1.10323 |
0.72 |
|
| 2010 |
Takhar S, Periyasamy-Thandavan S, Jackson WH, Singer A, Herberg S, Hill W, Huang S, Schoenlein P. Abstract 4846: IGF1 attenuates autophagic catabolism and apoptotic cell death in hormonally treated breast cancer cells via a MEK1 pathway Cancer Research. 70: 4846-4846. DOI: 10.1158/1538-7445.Am10-4846 |
0.705 |
|
| 2010 |
Periyasamy-Thandavan S, Singer A, Takhar S, Jackson WH, Samaddar J, Browning D, Schoenlein P. Abstract 4845: TONDU, a transcription factor that regulates prosurvival autophagy and the development of antiestrogen resistance in breast cancer Cancer Research. 70: 4845-4845. DOI: 10.1158/1538-7445.Am10-4845 |
0.681 |
|
| 2010 |
Karunakaran S, Schoenlein PV, Thangaraju M, Prasad PD, Ganapathy V. Abstract 4838: Alpha-methyltryptophan, a blocker of the amino acid transporter SLC6A14, induces autophagy and apoptosis in SLC6A14-positive breast cancer and colon cancer cell lines Cancer Research. 70: 4838-4838. DOI: 10.1158/1538-7445.Am10-4838 |
0.578 |
|
| 2009 |
Periyasamy-Thandavan S, Jiang M, Schoenlein P, Dong Z. Autophagy: molecular machinery, regulation, and implications for renal pathophysiology. American Journal of Physiology. Renal Physiology. 297: F244-56. PMID 19279132 DOI: 10.1152/Ajprenal.00033.2009 |
0.375 |
|
| 2009 |
Schoenlein PV, Periyasamy-Thandavan S, Samaddar JS, Jackson WH, Barrett JT. Autophagy facilitates the progression of ERalpha-positive breast cancer cells to antiestrogen resistance. Autophagy. 5: 400-3. PMID 19221464 DOI: 10.4161/Auto.5.3.7784 |
0.692 |
|
| 2009 |
Yang D, Wang S, Brooks C, Dong Z, Schoenlein PV, Kumar V, Ouyang X, Xiong H, Lahat G, Hayes-Jordan A, Lazar A, Pollock R, Lev D, Liu K. IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via repression of FLICE-like protein expression. Cancer Research. 69: 1080-8. PMID 19155307 DOI: 10.1158/0008-5472.Can-08-2520 |
0.497 |
|
| 2008 |
Samaddar JS, Gaddy VT, Duplantier J, Thandavan SP, Shah M, Smith MJ, Browning D, Rawson J, Smith SB, Barrett JT, Schoenlein PV. A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance. Molecular Cancer Therapeutics. 7: 2977-87. PMID 18790778 DOI: 10.1158/1535-7163.Mct-08-0447 |
0.723 |
|
| 2008 |
Kwon IK, Schoenlein PV, Delk J, Liu K, Thangaraju M, Dulin NO, Ganapathy V, Berger FG, Browning DD. Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis. Cancer. 112: 1462-70. PMID 18260092 DOI: 10.1002/Cncr.23334 |
0.416 |
|
| 2007 |
Schoenlein PV, Hou M, Samaddar JS, Gaddy VT, Thangaraju M, Lewis J, Johnson M, Ganapathy V, Kallab A, Barrett JT. Downregulation of retinoblastoma protein is involved in the enhanced cytotoxicity of 4-hydroxytamoxifen plus mifepristone combination therapy versus antiestrogen monotherapy of human breast cancer. International Journal of Oncology. 31: 643-55. PMID 17671693 DOI: 10.3892/Ijo.31.3.643 |
0.711 |
|
| 2007 |
Yang D, Thangaraju M, Greeneltch K, Browning DD, Schoenlein PV, Tamura T, Ozato K, Ganapathy V, Abrams SI, Liu K. Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells. Cancer Research. 67: 3301-9. PMID 17409439 DOI: 10.1158/0008-5472.Can-06-4068 |
0.433 |
|
| 2006 |
Wang J, Pabla N, Wang CY, Wang W, Schoenlein PV, Dong Z. Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53. American Journal of Physiology. Renal Physiology. 291: F1300-7. PMID 16849690 DOI: 10.1152/Ajprenal.00509.2005 |
0.403 |
|
| 2006 |
Hou Y, Gupta N, Schoenlein P, Wong E, Martindale R, Ganapathy V, Browning D. An anti-tumor role for cGMP-dependent protein kinase. Cancer Letters. 240: 60-8. PMID 16256267 DOI: 10.1016/J.Canlet.2005.08.035 |
0.313 |
|
| 2006 |
Hou Y, Wong E, Martin J, Schoenlein PV, Dostmann WR, Browning DD. A role for cyclic-GMP dependent protein kinase in anoikis. Cellular Signalling. 18: 882-8. PMID 16139477 DOI: 10.1016/J.Cellsig.2005.07.015 |
0.49 |
|
| 2004 |
Kallab AM, Dalton R, Hessler R, Yeh K, Wang T, Schoenlein P, May A, McKinnon S, Jillella A. Immunohistochemical tumor markers do not predict response to neoadjuvant doxorubicin and docetaxel in breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 794. PMID 28014122 DOI: 10.1200/jco.2004.22.14_suppl.794 |
0.397 |
|
| 2004 |
Yamamoto T, Staples J, Wataha J, Lewis J, Lockwood P, Schoenlein P, Rao S, Osaki T, Dickinson D, Kamatani T, Schuster G, Hsu S. Protective effects of EGCG on salivary gland cells treated with gamma-radiation or cis-platinum(II)diammine dichloride. Anticancer Research. 24: 3065-73. PMID 15517917 |
0.423 |
|
| 2004 |
Gaddy VT, Barrett JT, Delk JN, Kallab AM, Porter AG, Schoenlein PV. Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen-resistant breast cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 5215-25. PMID 15297425 DOI: 10.1158/1078-0432.Ccr-03-0637 |
0.721 |
|
| 2003 |
Liang Y, Hou M, Kallab AM, Barrett JT, El Etreby F, Schoenlein PV. Induction of antiproliferation and apoptosis in estrogen receptor negative MDA-231 human breast cancer cells by mifepristone and 4-hydroxytamoxifen combination therapy: a role for TGFbeta1. International Journal of Oncology. 23: 369-80. PMID 12851686 DOI: 10.3892/Ijo.23.2.369 |
0.687 |
|
| 2003 |
Hsu S, Lewis J, Singh B, Schoenlein P, Osaki T, Athar M, Porter AG, Schuster G. Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis. Anticancer Research. 23: 1533-9. PMID 12820420 |
0.362 |
|
| 2003 |
Schoenlein PV, Barrett JT, Kulharya A, Dohn MR, Sanchez A, Hou DY, McCoy J. Radiation therapy depletes extrachromosomally amplified drug resistance genes and oncogenes from tumor cells via micronuclear capture of episomes and double minute chromosomes. International Journal of Radiation Oncology, Biology, Physics. 55: 1051-65. PMID 12605985 DOI: 10.1016/S0360-3016(02)04473-5 |
0.368 |
|
| 2001 |
Moore P, El-sherbeny A, Roon P, Schoenlein PV, Ganapathy V, Smith SB. Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine. Experimental Eye Research. 73: 45-57. PMID 11428862 DOI: 10.1006/Exer.2001.1009 |
0.348 |
|
| 1999 |
El Etreby MF, Liang Y, Wrenn RW, Schoenlein PV. Additive effect of mifepristone and tamoxifen on apoptotic pathways in MCF-7 human breast cancer cells. Breast Cancer Research and Treatment. 51: 149-68. PMID 9879777 DOI: 10.1023/A:1006078032287 |
0.671 |
|
| 1998 |
Rund D, Dagan M, Dalyot-Herman N, Kimchi-Sarfaty C, Schoenlein PV, Gottesman MM, Oppenheim A. Efficient transduction of human hematopoietic cells with the human multidrug resistance gene 1 via SV40 pseudovirions. Human Gene Therapy. 9: 649-57. PMID 9551613 DOI: 10.1089/Hum.1998.9.5-649 |
0.41 |
|
| 1998 |
Schoenlein P, Welter D, Kulharya A, Sanchez A, Barrett J. Micronuclear entrapment of extrachromosomally amplified genes in irradiated tumor cells International Journal of Radiation Oncology*Biology*Physics. 42: 228. DOI: 10.1016/S0360-3016(98)80309-X |
0.32 |
|
| 1996 |
Campain JA, Slovak ML, Schoenlein PV, Popescu NC, Gottesman MM, Pastan I. Acquisition of multiple copies of a mutant topoisomerase IIalpha allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines. Somatic Cell and Molecular Genetics. 21: 451-71. PMID 8600572 DOI: 10.1007/Bf02310211 |
0.332 |
|
| 1995 |
Shen DW, Akiyama S, Schoenlein P, Pastan I, Gottesman MM. Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes. British Journal of Cancer. 71: 676-83. PMID 7710928 DOI: 10.1038/Bjc.1995.134 |
0.328 |
|
| 1995 |
Schoenlein PV. Role of gene amplification in drug resistance. Cancer Treatment and Research. 73: 167-200. PMID 7710905 DOI: 10.1007/978-1-4615-2632-2_9 |
0.401 |
|
| 1994 |
Schoenlein PV. Molecular cytogenetics of multiple drug resistance. Cytotechnology. 12: 63-89. PMID 7765332 DOI: 10.1007/Bf00744658 |
0.396 |
|
| 1993 |
Barrett JT, Schoenlein PV, Lipshultz C. Mitochondrial DNA damage and cell survival following photodynamic therapy and ionizing radiation International Journal of Radiation Oncology*Biology*Physics. 27: 308. DOI: 10.1016/0360-3016(93)90926-M |
0.323 |
|
| 1991 |
Schoenlein PV, Gottesman MM. Extrachromosomal DNA in human cancers. Journal of the National Cancer Institute. 82: 1798-800. PMID 2250291 DOI: 10.1093/Jnci/82.23.1798 |
0.349 |
|
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