| Year |
Citation |
Score |
| 2021 |
Grimont A, Leach SD, Chandwani R. Uncertain beginnings: acinar and ductal cell plasticity in the development of pancreatic cancer. Cellular and Molecular Gastroenterology and Hepatology. PMID 34352406 DOI: 10.1016/j.jcmgh.2021.07.014 |
0.36 |
|
| 2020 |
Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan CH, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP, Askan G, ... ... Leach SD, et al. Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer. Cancer Cell. PMID 32559497 DOI: 10.1016/J.Ccell.2020.05.010 |
0.336 |
|
| 2020 |
Latario CJ, Schoenfeld LW, Howarth CL, Pickrell LE, Begum F, Fischer DA, Grbovic-Huezo O, Leach SD, Sanchez Y, Smith KD, Higgs HN. Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner. Molecular Biology of the Cell. mbcE19110605. PMID 32267199 DOI: 10.1091/Mbc.E19-11-0605 |
0.389 |
|
| 2020 |
Moral JA, Leung J, Rojas LA, Ruan J, Zhao J, Sethna Z, Ramnarain A, Gasmi B, Gururajan M, Redmond D, Askan G, Bhanot U, Elyada E, Park Y, Tuveson DA, ... ... Leach SD, et al. ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity. Nature. PMID 32076273 DOI: 10.1038/S41586-020-2015-4 |
0.316 |
|
| 2019 |
Huang YH, Hu J, Chen F, Lecomte N, Basnet H, David CJ, Witkin MD, Allen PJ, Leach SD, Hollmann TJ, Iacobuzio-Donahue CA, Massague J. ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer. Cancer Discovery. PMID 31582374 DOI: 10.1158/2159-8290.Cd-19-0529 |
0.336 |
|
| 2019 |
Morris JP, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS, Lowe SW. α-Ketoglutarate links p53 to cell fate during tumour suppression. Nature. PMID 31534224 DOI: 10.1038/S41586-019-1577-5 |
0.381 |
|
| 2019 |
Luksza M, Leung JP, Solovyov A, Redmond D, Merad M, Gnjatic S, Iacubuzio-Donohue C, DeMatteo RP, Chan TA, Wolchock J, Leach SD, Greenbaum BD, Merghoub T, Balachandran VP. Abstract IA34: Mapping immune recognition of non-self neoantigens in human pancreatic cancer Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-Ia34 |
0.39 |
|
| 2019 |
Luksza M, Solovyov A, Vabret N, Balachandran V, Riaz N, Makarov V, Hellmann MD, Snyder A, Funt S, Remark R, Merad M, Gnjatic S, Bajorin DF, Rosenberg J, Leach S, et al. Abstract IA31: Measuring the emergence of non-self in tumors Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-Ia31 |
0.305 |
|
| 2019 |
Pan FC, Chong AA, Leach SD, Chen S, Evans T. Abstract C40: Dissecting key biologic processes in pancreatic cancer metastasis using a genetically defined 3D organoid model Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-C40 |
0.412 |
|
| 2019 |
Grimont A, Zhao Z, Leach SD, Chandwani R. Abstract B20: KrasG12D effector dependencies in the maintenance of pancreatic ductal adenocarcinoma Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-B20 |
0.38 |
|
| 2019 |
Leung J, Rojas LA, Ruan J, Zhao J, Gasmi B, Sethna Z, Ramnarain A, Bhanot U, Askan G, Gururajan M, Elyada E, Park Y, Tuveson DA, Gonen M, Leach SD, et al. Abstract B02: Tissue-specific innate lymphoid cells are novel targets for pancreatic cancer immunotherapy Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-B02 |
0.376 |
|
| 2018 |
Park JT, Leach SD. Zebrafish model of -initiated pancreatic cancer. Animal Cells and Systems. 22: 353-359. PMID 30533257 DOI: 10.1080/19768354.2018.1530301 |
0.452 |
|
| 2018 |
Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, ... ... Leach SD, et al. Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. Gastroenterology. PMID 29604293 DOI: 10.1053/J.Gastro.2018.03.041 |
0.421 |
|
| 2018 |
Lowery MA, Wong W, Jordan EJ, Lee JW, Kemel Y, Vijai J, Mandelker D, Zehir A, Capanu M, Salo-Mullen E, Arnold AG, Yu KH, Varghese AM, Kelsen DP, Brenner R, ... ... Leach SD, et al. Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms. Journal of the National Cancer Institute. PMID 29506128 DOI: 10.1093/Jnci/Djy024 |
0.382 |
|
| 2017 |
Socorro M, Criscimanna A, Riva P, Tandon M, Prasadan K, Guo P, Humar A, Husain SZ, Leach SD, Gittes GK, Esni F. Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas. Scientific Reports. 7: 17539. PMID 29235528 DOI: 10.1038/S41598-017-17884-Z |
0.414 |
|
| 2017 |
Balachandran VP, Łuksza M, Zhao JN, Makarov V, Moral JA, Remark R, Herbst B, Askan G, Bhanot U, Senbabaoglu Y, Wells DK, Cary CIO, Grbovic-Huezo O, Attiyeh M, Medina B, ... ... Leach SD, et al. Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer. Nature. PMID 29132146 DOI: 10.1038/Nature24462 |
0.363 |
|
| 2017 |
Mandelker D, Zhang L, Kemel Y, Stadler ZK, Joseph V, Zehir A, Pradhan N, Arnold A, Walsh MF, Li Y, Balakrishnan AR, Syed A, Prasad M, Nafa K, Carlo MI, ... ... Leach SD, et al. Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing. Jama. 318: 825-835. PMID 28873162 DOI: 10.1001/Jama.2017.11137 |
0.316 |
|
| 2017 |
Knudsen E, Vail P, Balaji U, Ngo H, Botros IW, Makarov V, Riaz N, Balachandran VP, Leach SD, Thompson DM, Chan TA, Witkiewicz AK. Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunological Markers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28348045 DOI: 10.1158/1078-0432.Ccr-17-0162 |
0.35 |
|
| 2017 |
Sinha S, Fu YY, Grimont A, Ketcham M, Lafaro KJ, Saglimbeni JA, Askan G, Bailey JM, Melchor JP, Zhong Y, Joo MG, Grbovic-Huezo O, Yang IH, Basturk O, Baker L, ... ... Leach SD, et al. PanIN neuroendocrine cells promote tumorigenesis via neuronal crosstalk. Cancer Research. PMID 28104683 DOI: 10.1158/0008-5472.Can-16-0899 |
0.385 |
|
| 2017 |
Jordan E, Lowery MA, Wong W, Kemel Y, Mukherjee S, Ravichandran V, Basturk O, Yu KH, Iacobuzio-Donahue C, Lincoln A, Varghese AM, Abou-Alfa GK, Leach SD, Klimstra DS, Allen PJ, et al. Prospective assessment for pathogenic germline alterations (PGA) in pancreas cancer (PAC). Journal of Clinical Oncology. 35: 4102-4102. DOI: 10.1200/Jco.2017.35.15_Suppl.4102 |
0.31 |
|
| 2016 |
Zhong Y, Macgregor-Das AM, Saunders T, Whittle M, Makohon-Moore A, Kohutek Z, Poling J, Herbst B, Javier B, Cope L, Leach SD, Hingorani SR, Iacobuzio-Donahue CA. Mutant p53 Together with TGFβ Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27637888 DOI: 10.1158/1078-0432.Ccr-15-1615 |
0.398 |
|
| 2016 |
Sinha S, Leach SD. New insights in the development of pancreatic cancer. Current Opinion in Gastroenterology. PMID 27454028 DOI: 10.1097/Mog.0000000000000295 |
0.388 |
|
| 2016 |
Perillo M, Wang YJ, Leach SD, Arnone MI. A pancreatic exocrine-like cell regulatory circuit operating in the upper stomach of the sea urchin Strongylocentrotus purpuratus larva. Bmc Evolutionary Biology. 16: 117. PMID 27230062 DOI: 10.1186/S12862-016-0686-0 |
0.409 |
|
| 2016 |
Hendley AM, Wang YJ, Polireddy K, Alsina J, Ahmed I, Lafaro KJ, Zhang H, Roy N, Savidge SG, Cao Y, Hebrok M, Maitra A, Reynolds A, Goggins MG, Younes M, ... ... Leach SD, et al. p120 Catenin suppresses basal epithelial cell extrusion in invasive pancreatic neoplasia. Cancer Research. PMID 27032419 DOI: 10.1158/0008-5472.Can-15-2268 |
0.402 |
|
| 2016 |
Jordan E, Basturk O, Leach SD, Klimstra DS, Allen PJ, Berger MF, Askan G, Yu KH, O'Reilly EM, Lowery MA. Assessment of genomic alterations in adenosquamous carcinoma of the pancreas (ASCOP). Journal of Clinical Oncology. 34: 261-261. DOI: 10.1200/Jco.2016.34.4_Suppl.261 |
0.328 |
|
| 2016 |
Ben-Aharon I, Elkabets M, Pelossof R, Yu KH, Allen PJ, Iacobuzio-Donahue CA, Leach SD, Lowery MA, Goodman KA, O'Reilly EM. Genomic landscape of pancreatic adenocarcinoma: Does age matter? Journal of Clinical Oncology. 34: 250-250. DOI: 10.1200/Jco.2016.34.4_Suppl.250 |
0.311 |
|
| 2016 |
Baker LA, Tiriac H, Corbo V, Boj SF, Hwang C, Chio IIC, Engle DD, Jager M, Ponz-Sarvise M, Spector MS, Gracanin A, Oni T, Yu KH, Boxtel Rv, Huch M, ... ... Leach SD, et al. Abstract B16: Using human patient-derived organoids to identify genetic dependencies in pancreatic cancer Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B16 |
0.463 |
|
| 2016 |
Polireddy K, Hendley A, Pruski MA, Lafaro K, Younes M, Maitra A, McAllister F, Iacobuzio-Donahue CA, Dar WA, Bynon JS, Leach SD, Bailey JM. Abstract PR03: Mutant p53 promotes adenocarcinoma in pancreatic ductal cells Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-Pr03 |
0.402 |
|
| 2016 |
Zhang Y, Sahin I, Gupta S, Maitra A, Bailey J, Leach S, McAllister F. Abstract 1447: Influence of IL-17-secreting immune cells in pancreatic cancer stemness Cancer Research. 76: 1447-1447. DOI: 10.1158/1538-7445.Am2016-1447 |
0.353 |
|
| 2015 |
Choi E, Hendley AM, Bailey JM, Leach SD, Goldenring JR. Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions. Gastroenterology. PMID 26677984 DOI: 10.1053/J.Gastro.2015.11.049 |
0.315 |
|
| 2015 |
Bailey JM, Hendley AM, Lafaro KJ, Pruski MA, Jones NC, Alsina J, Younes M, Maitra A, McAllister F, Iacobuzio-Donahue CA, Leach SD. p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells. Oncogene. PMID 26592447 DOI: 10.1038/Onc.2015.441 |
0.371 |
|
| 2015 |
Roeser JC, Leach SD, McAllister F. Emerging strategies for cancer immunoprevention. Oncogene. 34: 6029-6039. PMID 26364615 DOI: 10.1038/Onc.2015.98 |
0.308 |
|
| 2015 |
Wang YJ, Park JT, Parsons MJ, Leach SD. Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 244: 724-35. PMID 25773748 DOI: 10.1002/Dvdy.24271 |
0.404 |
|
| 2015 |
Leach SD. Interleukin interrupted: a new strategy for the treatment of pancreatic cancer. The Journal of Experimental Medicine. 212: 284. PMID 25754118 DOI: 10.1084/Jem.2123Insight1 |
0.361 |
|
| 2015 |
Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, ... ... Leach SD, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 160: 324-38. PMID 25557080 DOI: 10.1016/J.Cell.2014.12.021 |
0.435 |
|
| 2015 |
Hendley AM, Provost E, Bailey JM, Wang YJ, Cleveland MH, Blake D, Bittman RW, Roeser JC, Maitra A, Reynolds AB, Leach SD. p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Developmental Biology. 399: 41-53. PMID 25523391 DOI: 10.1016/J.Ydbio.2014.12.010 |
0.383 |
|
| 2015 |
Park JT, Johnson N, Liu S, Levesque M, Wang YJ, Ho H, Huso D, Maitra A, Parsons MJ, Prescott JD, Leach SD. Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey. Oncogene. 34: 2801-6. PMID 25065594 DOI: 10.1038/Onc.2014.223 |
0.385 |
|
| 2015 |
Lafaro KJ, Hendley A, Bailey J, Leach S. Abstract PR04: Clonal composition and clonal selection during PanIN progression Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-Pr04 |
0.4 |
|
| 2015 |
Bailey JM, Alsina J, McAllister F, Hendley A, Lafaro K, Habibulla A, Marchionni L, Maitra A, Leach S. Abstract A10: In search of Kras resistance genes: Whole transcriptome analysis identifies critical pathways mediating resistance and sensitivity to oncogenic Kras Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A10 |
0.45 |
|
| 2015 |
Hendley AM, Wang YJ, Alsina J, Ahmed I, Zhang H, Savidge S, Ho H, Reynolds A, Maitra A, Goggins M, Iacobuzio-Donahue C, Leach SD, Bailey JM. Abstract 4186: p120 catenin: A novel regulator of epithelial cell delamination in early Kras-driven pancreatic cancer Cancer Research. 75: 4186-4186. DOI: 10.1158/1538-7445.Am2015-4186 |
0.466 |
|
| 2014 |
Wang YJ, McAllister F, Bailey JM, Scott SG, Hendley AM, Leach SD, Ghosh B. Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. Plos One. 9: e113127. PMID 25405615 DOI: 10.1371/Journal.Pone.0113127 |
0.434 |
|
| 2014 |
McAllister F, Leach SD. Targeting IL-17 for pancreatic cancer prevention. Oncotarget. 5: 9530-1. PMID 25393980 DOI: 10.18632/Oncotarget.2618 |
0.321 |
|
| 2014 |
Provost E, Bailey JM, Aldrugh S, Liu S, Iacobuzio-Donahue C, Leach SD. The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer. Zebrafish. 11: 551-9. PMID 25380065 DOI: 10.1089/Zeb.2014.1024 |
0.424 |
|
| 2014 |
Schiavone M, Rampazzo E, Casari A, Battilana G, Persano L, Moro E, Liu S, Leach SD, Tiso N, Argenton F. Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer. Disease Models & Mechanisms. 7: 883-94. PMID 24878567 DOI: 10.1242/Dmm.014969 |
0.448 |
|
| 2014 |
McAllister F, Bailey JM, Alsina J, Nirschl CJ, Sharma R, Fan H, Rattigan Y, Roeser JC, Lankapalli RH, Zhang H, Jaffee EM, Drake CG, Housseau F, Maitra A, Kolls JK, ... ... Leach SD, et al. Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer Cell. 25: 621-37. PMID 24823639 DOI: 10.1016/J.Ccr.2014.03.014 |
0.34 |
|
| 2014 |
Minn I, Wang H, Mease RC, Byun Y, Yang X, Wang J, Leach SD, Pomper MG. A red-shifted fluorescent substrate for aldehyde dehydrogenase. Nature Communications. 5: 3662. PMID 24759454 DOI: 10.1038/Ncomms4662 |
0.31 |
|
| 2014 |
Bailey JM, Alsina J, Rasheed ZA, McAllister FM, Fu YY, Plentz R, Zhang H, Pasricha PJ, Bardeesy N, Matsui W, Maitra A, Leach SD. DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer. Gastroenterology. 146: 245-56. PMID 24096005 DOI: 10.1053/J.Gastro.2013.09.050 |
0.482 |
|
| 2014 |
Hendley AM, Bailey JM, Alsina J, Iacobuzio-Donahue C, Maitra A, Reynolds A, Leach SD. Abstract 66: p120 catenin: A novel regulator of PanIN epithelial cell delamination in preinvasive pancreatic cancer Cancer Research. 74: 66-66. DOI: 10.1158/1538-7445.Am2014-66 |
0.466 |
|
| 2014 |
Choi E, Hendley AM, Petersen C, Weis VG, Leach SD, Goldenring JR. 266 Active Kras Leads to Rapid Transdifferentiation of Gastric Chief Cells Into Metaplasia With Progression to Dysplasia and Invasive Cancer Gastroenterology. 146: S-64. DOI: 10.1016/S0016-5085(14)60225-0 |
0.366 |
|
| 2013 |
Park JT, Leach SD. TAILOR: transgene activation and inactivation using lox and rox in zebrafish. Plos One. 8: e85218. PMID 24391998 DOI: 10.1371/Journal.Pone.0085218 |
0.302 |
|
| 2013 |
Matsuda H, Parsons MJ, Leach SD. Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas. Plos One. 8: e74350. PMID 24147152 DOI: 10.1371/Journal.Pone.0074350 |
0.42 |
|
| 2013 |
Pashos E, Park JT, Leach S, Fisher S. Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish. Developmental Biology. 381: 471-81. PMID 23876428 DOI: 10.1016/J.Ydbio.2013.07.011 |
0.362 |
|
| 2013 |
Borden P, Houtz J, Leach SD, Kuruvilla R. Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation. Cell Reports. 4: 287-301. PMID 23850289 DOI: 10.1016/J.Celrep.2013.06.019 |
0.318 |
|
| 2013 |
Provost E, Weier CA, Leach SD. Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Zebrafish. 10: 161-9. PMID 23697888 DOI: 10.1089/Zeb.2013.0884 |
0.352 |
|
| 2013 |
Wang YJ, Bailey JM, Rovira M, Leach SD. Sphere-forming assays for assessment of benign and malignant pancreatic stem cells. Methods in Molecular Biology (Clifton, N.J.). 980: 281-90. PMID 23359160 DOI: 10.1007/978-1-62703-287-2_15 |
0.39 |
|
| 2013 |
McAllister F, Bailey JM, Alsina J, Nirschl C, Roeser J, Blake D, Lankapali R, Sears C, Jaffee EM, Kolls J, Drake CG, Pardoll DM, Leach SD. TH17 cells and early pancreatic tumorigenesis. Journal of Clinical Oncology. 31: 144-144. DOI: 10.1200/Jco.2013.31.4_Suppl.144 |
0.409 |
|
| 2013 |
McAllister F, Bailey JM, Alsina J, Nirschl C, Lankapalli R, Roeser J, Jaffee E, Sears C, Kolls JK, Drake CG, Pardoll DM, Leach SD. Abstract 2867: TH17 cells promote early pancreatic tumorigenesis. Cancer Research. 73: 2867-2867. DOI: 10.1158/1538-7445.Am2013-2867 |
0.406 |
|
| 2012 |
Maitra A, Leach SD. Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia. Cancer Cell. 22: 701-3. PMID 23238009 DOI: 10.1016/J.Ccr.2012.11.015 |
0.454 |
|
| 2012 |
Provost E, Wehner KA, Zhong X, Ashar F, Nguyen E, Green R, Parsons MJ, Leach SD. Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development (Cambridge, England). 139: 3232-41. PMID 22872088 DOI: 10.1242/Dev.077107 |
0.384 |
|
| 2012 |
Cleveland MH, Sawyer JM, Afelik S, Jensen J, Leach SD. Exocrine ontogenies: on the development of pancreatic acinar, ductal and centroacinar cells. Seminars in Cell & Developmental Biology. 23: 711-9. PMID 22743232 DOI: 10.1016/J.Semcdb.2012.06.008 |
0.423 |
|
| 2012 |
Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, Leach SD, Stanger BZ. EMT and dissemination precede pancreatic tumor formation. Cell. 148: 349-61. PMID 22265420 DOI: 10.1016/J.Cell.2011.11.025 |
0.469 |
|
| 2012 |
Gupta S, Maitra A, Ryu J, Zhang N, Bang S, Rovira M, Matthaei H, Hong S, Leach SD, Pan D. Abstract B83: Loss of the Hippo pathway effector Yap disrupts pancreatic morphogenesis and exacerbates exocrine pancreatitis. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-B83 |
0.453 |
|
| 2012 |
Bailey JM, Rasheed ZA, McAllister F, Alsina J, Auricchio GM, Maitra A, Hollingsworth MA, Matsui W, Leach SD. Abstract 5338: Pancreatic cancer tumor initiating cells are marked by the presence of cell surface associated acetylated alpha tubulin Cancer Research. 72: 5338-5338. DOI: 10.1158/1538-7445.Am2012-5338 |
0.422 |
|
| 2012 |
McAllister F, Bailey JM, Roeser J, Blake DT, Wick EC, Sears CL, Jaffee EM, Kolls JK, Drake CG, Pardoll DM, Leach SD. Abstract 2968: TH17 cells in early pancreatic tumorigenesis Cancer Research. 72: 2968-2968. DOI: 10.1158/1538-7445.Am2012-2968 |
0.416 |
|
| 2012 |
Leach S. Modelling pancreatic cancer in mice and zebrafish Pancreatology. 12. DOI: 10.1016/J.Pan.2012.07.005 |
0.374 |
|
| 2011 |
Liu S, Leach SD. Screening pancreatic oncogenes in zebrafish using the Gal4/UAS system. Methods in Cell Biology. 105: 367-81. PMID 21951538 DOI: 10.1016/B978-0-12-381320-6.00015-1 |
0.456 |
|
| 2011 |
Ghosh B, Leach SD. p53: Guardian of pancreatic epithelial identity. Cell Cycle (Georgetown, Tex.). 10: 1717. PMID 21597331 DOI: 10.4161/Cc.10.11.15686 |
0.358 |
|
| 2011 |
Liu S, Leach SD. Zebrafish models for cancer. Annual Review of Pathology. 6: 71-93. PMID 21261518 DOI: 10.1146/Annurev-Pathol-011110-130330 |
0.34 |
|
| 2011 |
Bailey JM, Rasheed Z, Matsui W, Maitra A, Hollingsworth MA, Leach SD. Abstract 2449: Pancreatic cancer tumor initiating cells are marked by the presence of a primary cilium Cancer Research. 71: 2449-2449. DOI: 10.1158/1538-7445.Am2011-2449 |
0.457 |
|
| 2010 |
Rovira M, Scott SG, Liss AS, Jensen J, Thayer SP, Leach SD. Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proceedings of the National Academy of Sciences of the United States of America. 107: 75-80. PMID 20018761 DOI: 10.1073/Pnas.0912589107 |
0.369 |
|
| 2010 |
Liu S, Parsons MJ, Davison JM, Leach SD. Abstract 4162: Gal4/UAS-mediated pancreatic tumorigenesis in zebrafish Cancer Research. 70: 4162-4162. DOI: 10.1158/1538-7445.Am10-4162 |
0.445 |
|
| 2009 |
Wescott MP, Rovira M, Reichert M, von Burstin J, Means A, Leach SD, Rustgi AK. Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factor. Molecular Biology of the Cell. 20: 4838-44. PMID 19793922 DOI: 10.1091/Mbc.E09-03-0203 |
0.426 |
|
| 2009 |
Parsons MJ, Pisharath H, Yusuff S, Moore JC, Siekmann AF, Lawson N, Leach SD. Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mechanisms of Development. 126: 898-912. PMID 19595765 DOI: 10.1016/J.Mod.2009.07.002 |
0.415 |
|
| 2009 |
Burstin Jv, Scott S, Reichert M, Wescott MP, Leach SD, Rustgi AK. 161 A Novel Mouse Model, K19CreERT2; Rosa26R, for the Selective and Specific Marking of Pancreatic Ductal Epithelial Cells Gastroenterology. 136. DOI: 10.1016/S0016-5085(09)60144-X |
0.763 |
|
| 2008 |
Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach SD, Maitra A. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 18913-8. PMID 19028870 DOI: 10.1073/Pnas.0810097105 |
0.386 |
|
| 2008 |
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, ... ... Leach SD, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (New York, N.Y.). 321: 1801-6. PMID 18772397 DOI: 10.1126/Science.1164368 |
0.39 |
|
| 2008 |
Halpern ME, Rhee J, Goll MG, Akitake CM, Parsons M, Leach SD. Gal4/UAS transgenic tools and their application to zebrafish. Zebrafish. 5: 97-110. PMID 18554173 DOI: 10.1089/Zeb.2008.0530 |
0.332 |
|
| 2008 |
Park SW, Davison JM, Rhee J, Hruban RH, Maitra A, Leach SD. Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology. 134: 2080-90. PMID 18549880 DOI: 10.1053/J.Gastro.2008.02.084 |
0.469 |
|
| 2008 |
Dong PD, Provost E, Leach SD, Stainier DY. Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas. Genes & Development. 22: 1445-50. PMID 18519637 DOI: 10.1101/Gad.1663208 |
0.427 |
|
| 2008 |
Fendrich V, Esni F, Garay MV, Feldmann G, Habbe N, Jensen JN, Dor Y, Stoffers D, Jensen J, Leach SD, Maitra A. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology. 135: 621-31. PMID 18515092 DOI: 10.1053/J.Gastro.2008.04.011 |
0.445 |
|
| 2008 |
Davison JM, Woo Park S, Rhee JM, Leach SD. Characterization of Kras-mediated pancreatic tumorigenesis in zebrafish. Methods in Enzymology. 438: 391-417. PMID 18413263 DOI: 10.1016/S0076-6879(07)38027-0 |
0.433 |
|
| 2008 |
Wescott MP, Burstin Jv, Deramaudt TB, Leach SD, Rustgi AK. T1900 Hepatocyte Growth Factor in Concert with PDX-1 Homeodomain Transcription Factor Regulate Pancreatic Ductal Cell Branching Morphogenesis Gastroenterology. 134. DOI: 10.1016/S0016-5085(08)62742-0 |
0.32 |
|
| 2008 |
Scott S, Leach SD. Identifying novel targets of Ptf1a using ChIP-on-chip technology Developmental Biology. 319: 593-594. DOI: 10.1016/J.Ydbio.2008.05.502 |
0.703 |
|
| 2007 |
Konieczny SF, Leach SD. Metaplastic metamorphoses in the mammalian pancreas. Gastroenterology. 133: 2056-9. PMID 18054579 DOI: 10.1053/J.Gastro.2007.10.061 |
0.349 |
|
| 2007 |
Godinho L, Williams PR, Claassen Y, Provost E, Leach SD, Kamermans M, Wong RO. Nonapical symmetric divisions underlie horizontal cell layer formation in the developing retina in vivo. Neuron. 56: 597-603. PMID 18031679 DOI: 10.1016/J.Neuron.2007.09.036 |
0.306 |
|
| 2007 |
Biankin SA, Collector MI, Biankin AV, Brown LJ, Kleeberger W, Devereux WL, Zahnow CA, Baylin SB, Watkins DN, Sharkis SJ, Leach SD. A histological survey of green fluorescent protein expression in 'green' mice: implications for stem cell research. Pathology. 39: 247-51. PMID 17454756 DOI: 10.1080/00313020701230807 |
0.31 |
|
| 2007 |
Desai BM, Oliver-Krasinski J, De Leon DD, Farzad C, Hong N, Leach SD, Stoffers DA. Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. The Journal of Clinical Investigation. 117: 971-7. PMID 17404620 DOI: 10.1172/Jci29988 |
0.413 |
|
| 2007 |
Murtaugh LC, Leach SD. A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers. Cancer Cell. 11: 211-3. PMID 17349578 DOI: 10.1016/J.Ccr.2007.02.020 |
0.467 |
|
| 2007 |
Davison JM, Akitake CM, Goll MG, Rhee JM, Gosse N, Baier H, Halpern ME, Leach SD, Parsons MJ. Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish. Developmental Biology. 304: 811-24. PMID 17335798 DOI: 10.1016/J.Ydbio.2007.01.033 |
0.319 |
|
| 2007 |
Jarikji ZH, Vanamala S, Beck CW, Wright CV, Leach SD, Horb ME. Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Developmental Biology. 304: 786-99. PMID 17320068 DOI: 10.1016/J.Ydbio.2007.01.027 |
0.372 |
|
| 2007 |
Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy AM. Wnt/beta-catenin signaling is required for development of the exocrine pancreas. Bmc Developmental Biology. 7: 4. PMID 17222338 DOI: 10.1186/1471-213X-7-4 |
0.343 |
|
| 2007 |
Habbe N, Meguid RA, Fendrich V, Feldmann G, Hruban RH, Leach SD, Maitra A. Spontaneous Development Of Murine Pancreatic Intraepithelial Neoplasia (mpanin) In Ela-creert2; Lsl-kras: Insights Into Cellular Origins Of Pancreatic Cancerg12d: Insights Into Cellular Origins Of Pancreatic Cancer Mice: Insights Into Cellular Origins Of Pancreatic Cancer Pancreas. 35: 405-406. DOI: 10.1097/01.Mpa.0000297711.06220.10 |
0.435 |
|
| 2007 |
Dong PDS, Leach S, Stainier DY. ptf1a determines pancreatic exocrine versus endocrine fates Developmental Biology. 306: 416. DOI: 10.1016/J.Ydbio.2007.03.641 |
0.397 |
|
| 2007 |
Stainier DY, Dong PDS, Leach S. WITHDRAWN: ptf1a determines pancreatic exocrine versus endocrine fates Developmental Biology. DOI: 10.1016/J.Ydbio.2007.03.294 |
0.397 |
|
| 2007 |
Meguid RA, Fendrich V, Esni F, Feldmann G, Maitra A, Leach SD. 35: Sonic Hedgehog misexpression causes expansion of mesenchymal elements in adult mouse pancreas Journal of Surgical Research. 137: 165. DOI: 10.1016/J.Jss.2006.12.044 |
0.4 |
|
| 2005 |
Means AL, Meszoely IM, Suzuki K, Miyamoto Y, Rustgi AK, Coffey RJ, Wright CV, Stoffers DA, Leach SD. Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (Cambridge, England). 132: 3767-76. PMID 16020518 DOI: 10.1242/Dev.01925 |
0.438 |
|
| 2005 |
Fukushima N, Koopmann J, Sato N, Prasad N, Carvalho R, Leach SD, Hruban RH, Goggins M. Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 18: 779-87. PMID 15791284 DOI: 10.1038/Modpathol.3800337 |
0.433 |
|
| 2005 |
Leach SD. Epithelial differentiation in pancreatic development and neoplasia: new niches for nestin and Notch. Journal of Clinical Gastroenterology. 39: S78-82. PMID 15758664 DOI: 10.1097/01.Mcg.0000155547.83901.A3 |
0.414 |
|
| 2005 |
Prasad NB, Biankin AV, Fukushima N, Maitra A, Dhara S, Elkahloun AG, Hruban RH, Goggins M, Leach SD. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Research. 65: 1619-26. PMID 15753353 DOI: 10.1158/0008-5472.Can-04-1413 |
0.402 |
|
| 2005 |
Esni F, Miyamoto Y, Leach SD, Ghosh B. Primary explant cultures of adult and embryonic pancreas. Methods in Molecular Medicine. 103: 259-71. PMID 15542912 DOI: 10.1385/1-59259-780-7:259 |
0.456 |
|
| 2004 |
Fukushima N, Sato N, Prasad N, Leach SD, Hruban RH, Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene. 23: 9042-51. PMID 15489895 DOI: 10.1038/Sj.Onc.1208117 |
0.372 |
|
| 2004 |
Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, Ball DW, Leach SD. Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development (Cambridge, England). 131: 4213-24. PMID 15280211 DOI: 10.1242/Dev.01280 |
0.428 |
|
| 2004 |
Lin JW, Biankin AV, Horb ME, Ghosh B, Prasad NB, Yee NS, Pack MA, Leach SD. Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Developmental Biology. 270: 474-86. PMID 15183727 DOI: 10.1016/J.Ydbio.2004.02.023 |
0.37 |
|
| 2004 |
House MG, Yeo CJ, Cameron JL, Campbell KA, Schulick RD, Leach SD, Hruban RH, Horton KM, Fishman EK, Lillemoe KD. Predicting resectability of periampullary cancer with three-dimensional computed tomography. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 8: 280-8. PMID 15019924 DOI: 10.1016/J.Gassur.2003.12.011 |
0.307 |
|
| 2004 |
Leach SD. Mouse models of pancreatic cancer: the fur is finally flying! Cancer Cell. 5: 7-11. PMID 14749121 DOI: 10.1016/S1535-6108(03)00337-4 |
0.456 |
|
| 2004 |
Esni F, Stoffers DA, Takeuchi T, Leach SD. Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mechanisms of Development. 121: 15-25. PMID 14706696 DOI: 10.1016/J.Mod.2003.08.010 |
0.435 |
|
| 2004 |
Lin JW, Biankin AV, Horb ME, Ghosh B, Prasad NB, Yee NS, Pack MA, Leach SD. Erratum: Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas (Developmental Biology (2004) 270 (474-486) DOI: 10.1016/j.ydbio.2004.02.023) Developmental Biology. 274: 490. DOI: 10.1016/J.Ydbio.2004.07.002 |
0.309 |
|
| 2003 |
Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell. 3: 565-76. PMID 12842085 DOI: 10.1016/S1535-6108(03)00140-5 |
0.436 |
|
| 2003 |
Hardacre JM, Iacobuzio-Donahue CA, Sohn TA, Abraham SC, Yeo CJ, Lillemoe KD, Choti MA, Campbell KA, Schulick RD, Hruban RH, Cameron JL, Leach SD. Results of pancreaticoduodenectomy for lymphoplasmacytic sclerosing pancreatitis. Annals of Surgery. 237: 853-8; discussion 85. PMID 12796582 DOI: 10.1097/01.Sla.0000071516.54864.C1 |
0.325 |
|
| 2003 |
Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC, Wright CV, Coffey RJ, Leach SD. Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology. 124: 1020-36. PMID 12671899 DOI: 10.1053/Gast.2003.50150 |
0.353 |
|
| 2003 |
Abraham SC, Leach S, Yeo CJ, Cameron JL, Murakata LA, Boitnott JK, Albores-Saavedra J, Hruban RH. Eosinophilic pancreatitis and increased eosinophils in the pancreas. The American Journal of Surgical Pathology. 27: 334-42. PMID 12604889 DOI: 10.1097/00000478-200303000-00006 |
0.397 |
|
| 2002 |
Wagner M, Weber CK, Bressau F, Greten FR, Stagge V, Ebert M, Leach SD, Adler G, Schmid RM. Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells. Gastroenterology. 122: 1898-912. PMID 12055597 DOI: 10.1053/Gast.2002.33594 |
0.336 |
|
| 2002 |
Crawford HC, Scoggins CR, Washington MK, Matrisian LM, Leach SD. Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. The Journal of Clinical Investigation. 109: 1437-44. PMID 12045257 DOI: 10.1172/Jci15051 |
0.378 |
|
| 2001 |
Means AL, Leach SD. Lineage Commitment and Cellular Differentiation in Exocrine Pancreas Pancreatology. 1: 587-596. PMID 12120241 DOI: 10.1159/000055868 |
0.433 |
|
| 2000 |
Scoggins CR, Meszoely IM, Wada M, Means AL, Yang L, Leach SD. p53-dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas. American Journal of Physiology-Gastrointestinal and Liver Physiology. 279. PMID 11005771 DOI: 10.1152/Ajpgi.2000.279.4.G827 |
0.372 |
|
| 2000 |
Song SY, Meszoely IM, Coffey RJ, Pietenpol JA, Leach SD. K-Ras-independent effects of the farnesyl transferase inhibitor L- 744,832 on cyclin B1/Cdc2 kinase activity, G2/M cell cycle progression and apoptosis in human pancreatic ductal adenocarcinoma cells Neoplasia. 2: 261-272. PMID 10935512 DOI: 10.1038/Sj.Neo.7900088 |
0.344 |
|
| 1999 |
Song SY, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR, Sandgren EP, Coffey RJ, Wright CV, Leach SD. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology. 117: 1416-26. PMID 10579983 DOI: 10.1016/S0016-5085(99)70292-1 |
0.386 |
|
| 1999 |
Scoggins CR, Meszoely IM, Blanke CD, Beauchamp RD, Leach SD. Nonoperative management of primary colorectal cancer in patients with stage IV disease. Annals of Surgical Oncology. 6: 651-7. PMID 10560850 DOI: 10.1007/S10434-999-0651-X |
0.316 |
|
| 1999 |
Bold RJ, Charnsangavej C, Cleary KR, Jennings M, Madary A, Leach SD, Abbruzzese JL, Pisters PWT, Lee JE, Evans DB. Major vascular resection as part of pancreaticoduodenectomy for cancer: radiologic, intraoperative, and pathologic analysis☆☆☆ Journal of Gastrointestinal Surgery. 3: 233-243. PMID 10481116 DOI: 10.1016/S1091-255X(99)80065-1 |
0.319 |
|
| 1998 |
Leach SD, Lee JE, Charnsangavej C, Cleary KR, Lowy AM, Fenoglio CJ, Pisters PW, Evans DB. Survival following pancreaticoduodenectomy with resection of the superior mesenteric–portal vein confluence for adenocarcinoma of the pancreatic head British Journal of Surgery. 85: 611-617. PMID 9635805 DOI: 10.1046/J.1365-2168.1998.00641.X |
0.308 |
|
| 1998 |
Song SY, Sizemore N, Meszoely I, Coffey RJ, Leach SD. Differential sensitivity of pancreatic cancer cells to farnesyl transferase inhibitor (FTI) correlates with altered subcellular ras distribution and G2/M cell cycle arrest Gastroenterology. 114. DOI: 10.1016/S0016-5085(98)82798-4 |
0.349 |
|
| 1997 |
McMasters KM, Tuttle TM, Leach SD, Rich T, Cleary KR, Evans DB, Curley SA. Neoadjuvant chemoradiation for extrahepatic cholangiocarcinoma American Journal of Surgery. 174: 605-609. PMID 9409582 DOI: 10.1016/S0002-9610(97)00203-1 |
0.305 |
|
| 1997 |
Leach SD, Blanke CD, Choy H. Pancreatic adenocarcinoma: Adjuvant, neoadjuvant, and intraoperative chemoradiation Seminars in Radiation Oncology. 7: 24-32. DOI: 10.1016/S1053-4296(97)80057-4 |
0.36 |
|
| 1996 |
Fuhrman GM, Leach SD, Staley CA, Cusack JC, Charnsangavej C, Cleary KR, El-Naggar AK, Fenoglio CJ, Lee JE, Evans DB. Rationale for En Bloc Vein Resection in the Treatment of Pancreatic Adenocarcinoma Adherent to the Superior Mesenteric-Portal Vein Confluence Annals of Surgery. 223: 154-162. PMID 8597509 DOI: 10.1097/00000658-199602000-00007 |
0.301 |
|
| 1995 |
Leach SD, Rose JA, Lowy AM, Lee JE, Charnsangavej C, Abbruzzese JL, Katz RL, Evans DB. Significance of peritoneal cytology in patients with potentially resectable adenocarcinoma of the pancreatic head Surgery. 118: 472-478. PMID 7652681 DOI: 10.1016/S0039-6060(05)80361-7 |
0.318 |
|
| 1995 |
Leach S, Lowy A, Fuhrman G, Lee J, Curley S, Evans D. Pancreatic malignancy involving the superior mesenteric-portal vein confluence is not a contraindication to pancreaticoduodenectomy Gastroenterology. 108. DOI: 10.1016/0016-5085(95)29210-1 |
0.376 |
|
| 1995 |
Evans DB, Abbruzzese JL, Lee JE, Leach SD, Charnsangavej C, Cleary KR, Buchholz DJ, Rich TA. Preoperative chemoradiation for adenocarcinoma of the pancreas: M.D. Anderson experience Seminars in Surgical Oncology. 11: 132-140. DOI: 10.1002/Ssu.2980110210 |
0.385 |
|
| 1993 |
Leach SD, Bilchik AJ, Karapetian O, Gorelick FS, Modlin IM. Influence of chloroquine on diet-induced pancreatitis Pancreas. 8: 64-69. PMID 7678327 DOI: 10.1097/00006676-199301000-00013 |
0.341 |
|
| 1992 |
Leach SD, Gorelick FS, Modlin IM. New perspectives on acute pancreatitis Scandinavian Journal of Gastroenterology. 27: 29-38. PMID 1439566 DOI: 10.3109/00365529209095976 |
0.344 |
|
| 1991 |
Leach SD, Modlin IM, Scheele GA, Gorelick FS. Intracellular activation of digestive zymogens in rat pancreatic acini stimulation by high doses of cholecystokinin Journal of Clinical Investigation. 87: 362-366. PMID 1985109 DOI: 10.1172/Jci114995 |
0.323 |
|
| 1990 |
Leach SD, Gorelick FS, Modlin IM. Acute pancreatitis at its Centenary: The contribution of Reginald Fitz Annals of Surgery. 212: 109-113. PMID 2194439 DOI: 10.1097/00000658-199007000-00014 |
0.387 |
|
| 1990 |
Bilchik AJ, Leach SD, Zucker KA, Modlin IM. Experimental models of acute pancreatitis. Journal of Surgical Research. 48: 639-647. PMID 2194073 DOI: 10.1016/0022-4804(90)90245-W |
0.399 |
|
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