| Year |
Citation |
Score |
| 2023 |
Chen W, Ma C, Wang H, Liu L, Tong J, Witkowski M, Aifantis I, Ghassemi S. A bioengineered immunocompetent human leukemia chip for preclinical screening of CAR T cell immunotherapy. Research Square. PMID 37131801 DOI: 10.21203/rs.3.rs-2762929/v1 |
0.305 |
|
| 2023 |
Glytsou C, Chen X, Zacharioudakis E, Al-Santli W, Zhou H, Nadorp B, Lee S, Lasry A, Sun Z, Papaioannou D, Cammer M, Wang K, Zal T, Zal MA, Carter BZ, ... ... Aifantis I, et al. Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia. Cancer Discovery. PMID 37088914 DOI: 10.1158/2159-8290.CD-22-0601 |
0.53 |
|
| 2023 |
Battistello E, Hixon KA, Comstock DE, Collings CK, Chen X, Rodriguez Hernaez J, Lee S, Cervantes KS, Hinkley MM, Ntatsoulis K, Cesarano A, Hockemeyer K, Haining WN, Witkowski MT, Qi J, ... ... Aifantis I, et al. Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion. Molecular Cell. PMID 36944333 DOI: 10.1016/j.molcel.2023.02.026 |
0.605 |
|
| 2023 |
Lasry A, Nadorp B, Fornerod M, Nicolet D, Wu H, Walker CJ, Sun Z, Witkowski MT, Tikhonova AN, Guillamot-Ruano M, Cayanan G, Yeaton A, Robbins G, Obeng EA, Tsirigos A, ... ... Aifantis I, et al. Author Correction: An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature Cancer. PMID 36658429 DOI: 10.1038/s43018-023-00518-x |
0.462 |
|
| 2023 |
Tan J, Shenker-Tauris N, Rodriguez-Hernaez J, Wang E, Sakellaropoulos T, Boccalatte F, Thandapani P, Skok J, Aifantis I, Fenyö D, Xia B, Tsirigos A. Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening. Nature Biotechnology. PMID 36624151 DOI: 10.1038/s41587-022-01612-8 |
0.548 |
|
| 2022 |
Lasry A, Nadorp B, Fornerod M, Nicolet D, Wu H, Walker CJ, Sun Z, Witkowski MT, Tikhonova AN, Guillamot-Ruano M, Cayanan G, Yeaton A, Robbins G, Obeng EA, Tsirigos A, ... ... Aifantis I, et al. An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia. Nature Cancer. PMID 36581735 DOI: 10.1038/s43018-022-00480-0 |
0.557 |
|
| 2022 |
Kedmi R, Najar TA, Mesa KR, Grayson A, Kroehling L, Hao Y, Hao S, Pokrovskii M, Xu M, Talbot J, Wang J, Germino J, Lareau CA, Satpathy AT, Anderson MS, ... ... Aifantis I, et al. A RORγt cell instructs gut microbiota-specific T cell differentiation. Nature. PMID 36071167 DOI: 10.1038/s41586-022-05089-y |
0.315 |
|
| 2022 |
Yeaton A, Cayanan G, Loghavi S, Dolgalev I, Leddin EM, Loo CE, Torabifard H, Nicolet D, Wang J, Corrigan K, Paraskevopoulou V, Starczynowski DT, Wang E, Abdel-Wahab O, Viny AD, ... ... Aifantis I, et al. The impact of inflammation-induced tumor plasticity during myeloid transformation. Cancer Discovery. PMID 35924979 DOI: 10.1158/2159-8290.CD-21-1146 |
0.688 |
|
| 2022 |
Carcamo S, Nguyen CB, Grossi E, Filipescu D, Alpsoy A, Dhiman A, Sun D, Narang S, Imig J, Martin TC, Parsons R, Aifantis I, Tsirigos A, Aguirre-Ghiso JA, Dykhuizen EC, et al. Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma. Cell Reports. 39: 110637. PMID 35385731 DOI: 10.1016/j.celrep.2022.110637 |
0.568 |
|
| 2022 |
Muto T, Guillamot M, Yeung J, Fang J, Bennett J, Nadorp B, Lasry A, Redondo LZ, Choi K, Gong Y, Walker CS, Hueneman K, Bolanos LC, Barreyro L, Lee LH, ... ... Aifantis I, et al. TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. Cell Stem Cell. PMID 35045331 DOI: 10.1016/j.stem.2021.12.007 |
0.363 |
|
| 2022 |
Thandapani P, Kloetgen A, Witkowski MT, Glytsou C, Lee AK, Wang E, Wang J, LeBoeuf SE, Avrampou K, Papagiannakopoulos T, Tsirigos A, Aifantis I. Valine tRNA levels and availability regulate complex I assembly in leukaemia. Nature. 601: 428-433. PMID 34937946 DOI: 10.1038/s41586-021-04244-1 |
0.578 |
|
| 2021 |
Kim RH, Nomikou S, Coudray N, Jour G, Dawood Z, Hong R, Esteva E, Sakellaropoulos T, Donnelly D, Moran U, Hatzimemos A, Weber JS, Razavian N, Aifantis I, Fenyo D, et al. Deep learning and pathomics analyses reveal cell nuclei as important features for mutation prediction of BRAF-mutated melanomas. The Journal of Investigative Dermatology. PMID 34757067 DOI: 10.1016/j.jid.2021.09.034 |
0.488 |
|
| 2021 |
Akhmetzyanova I, Aaron T, Galbo P, Tikhonova A, Dolgalev I, Tanaka M, Aifantis I, Zheng D, Zang X, Fooksman D. Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα. Blood Advances. 5: 3592-3608. PMID 34550328 DOI: 10.1182/bloodadvances.2021005327 |
0.584 |
|
| 2021 |
Wang E, Zhou H, Nadorp B, Cayanan G, Chen X, Yeaton AH, Nomikou S, Witkowski MT, Narang S, Kloetgen A, Thandapani P, Ravn-Boess N, Tsirigos A, Aifantis I. Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation. Cell Stem Cell. PMID 33450187 DOI: 10.1016/j.stem.2020.12.005 |
0.617 |
|
| 2021 |
Xiong H, Mancini M, Gobert M, Shen S, Furtado GC, Lira SA, Parkhurst CN, Garambois V, Brengues M, Tadokoro CE, Trimarchi T, Gómez-López G, Singh A, Khiabanian H, Minuzzo S, ... ... Aifantis I, et al. Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia. Theranostics. 11: 1594-1608. PMID 33408769 DOI: 10.7150/thno.48067 |
0.314 |
|
| 2020 |
Ma C, Witkowski MT, Harris J, Dolgalev I, Sreeram S, Qian W, Tong J, Chen X, Aifantis I, Chen W. Leukemia-on-a-chip: Dissecting the chemoresistance mechanisms in B cell acute lymphoblastic leukemia bone marrow niche. Science Advances. 6. PMID 33127669 DOI: 10.1126/sciadv.aba5536 |
0.621 |
|
| 2020 |
Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, ... ... Aifantis I, et al. CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32883883 DOI: 10.1073/Pnas.2003228117 |
0.414 |
|
| 2020 |
Bohin N, Keeley TM, Carulli AJ, Walker EM, Carlson EA, Gao J, Aifantis I, Siebel CW, Rajala MW, Myers MG, Jones JC, Brindley CD, Dempsey PJ, Samuelson LC. Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition. Stem Cell Reports. PMID 32531190 DOI: 10.1016/J.Stemcr.2020.05.010 |
0.332 |
|
| 2020 |
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, ... ... Aifantis I, et al. Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia. Cancer Cell. PMID 32470390 DOI: 10.1016/J.Ccell.2020.04.015 |
0.684 |
|
| 2020 |
Zhou Y, Han C, Wang E, Lorch AH, Serafin V, Cho BK, Guttierrez Diaz BT, Calvo J, Fang C, Khodadadi-Jamayran A, Tabaglio T, Marier C, Kuchmiy A, Sun L, Yacu G, ... ... Aifantis I, et al. Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia. Cancer Discovery. PMID 32444465 DOI: 10.1158/2159-8290.Cd-19-1436 |
0.608 |
|
| 2020 |
Koscsó B, Kurapati S, Rodrigues RR, Nedjic J, Gowda K, Shin C, Soni C, Ashraf AZ, Purushothaman I, Palisoc M, Xu S, Sun H, Chodisetti SB, Lin E, Mack M, ... ... Aifantis I, et al. Gut-resident CX3CR1 macrophages induce tertiary lymphoid structures and IgA response in situ. Science Immunology. 5. PMID 32276965 DOI: 10.1126/Sciimmunol.Aax0062 |
0.313 |
|
| 2020 |
Kloetgen A, Thandapani P, Ntziachristos P, Ghebrechristos Y, Nomikou S, Lazaris C, Chen X, Hu H, Bakogianni S, Wang J, Fu Y, Boccalatte F, Zhong H, Paietta E, Trimarchi T, ... ... Aifantis I, et al. Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia. Nature Genetics. PMID 32203470 DOI: 10.1038/S41588-020-0602-9 |
0.584 |
|
| 2020 |
Lazaris C, Aifantis I, Tsirigos A. On Epigenetic Plasticity and Genome Topology. Trends in Cancer. 6: 177-180. PMID 32101721 DOI: 10.1016/J.Trecan.2020.01.006 |
0.499 |
|
| 2020 |
Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho MG, Moubarak RS, Sánchez-Sendra B, Kloetgen A, Davalos V, Imig J, Wu P, Vasudevaraja V, Argibay D, Lilja K, Tabaglio T, Monteagudo C, ... ... Aifantis I, et al. Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. Cancer Cell. 37: 55-70.e15. PMID 31935372 DOI: 10.1016/J.Ccell.2019.12.007 |
0.57 |
|
| 2020 |
Witkowski MT, Kousteni S, Aifantis I. Mapping and targeting of the leukemic microenvironment. The Journal of Experimental Medicine. 217. PMID 31873722 DOI: 10.1084/Jem.20190589 |
0.419 |
|
| 2019 |
Sakellaropoulos T, Vougas K, Narang S, Koinis F, Kotsinas A, Polyzos A, Moss TJ, Piha-Paul S, Zhou H, Kardala E, Damianidou E, Alexopoulos LG, Aifantis I, Townsend PA, Panayiotidis MI, et al. A Deep Learning Framework for Predicting Response to Therapy in Cancer. Cell Reports. 29: 3367-3373.e4. PMID 31825821 DOI: 10.1016/J.Celrep.2019.11.017 |
0.512 |
|
| 2019 |
Rodriguez S, Abundis C, Boccalatte F, Mehrotra P, Chiang MY, Yui MA, Wang L, Zhang H, Zollman A, Bonfim-Silva R, Kloetgen A, Palmer J, Sandusky G, Wunderlich M, Kaplan MH, ... ... Aifantis I, et al. Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL. Leukemia. PMID 31772299 DOI: 10.1038/S41375-019-0653-Z |
0.347 |
|
| 2019 |
Papaioannou D, Petri A, Dovey OM, Terreri S, Wang E, Collins FA, Woodward LA, Walker AE, Nicolet D, Pepe F, Kumchala P, Bill M, Walker CJ, Karunasiri M, Mrózek K, ... ... Aifantis I, et al. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature Communications. 10: 5351. PMID 31767858 DOI: 10.1038/S41467-019-13259-2 |
0.346 |
|
| 2019 |
Witkowski MT, Lasry A, Carroll WL, Aifantis I. Immune-Based Therapies in Acute Leukemia. Trends in Cancer. 5: 604-618. PMID 31706508 DOI: 10.1016/J.Trecan.2019.07.009 |
0.355 |
|
| 2019 |
Xiu Y, Dong Q, Fu L, Bossler A, Tang X, Boyce B, Borcherding N, Leidinger M, Sardina JL, Xue HH, Li Q, Feldman A, Aifantis I, Boccalatte F, Wang L, et al. Coactivation of NF-κB and Notch signaling is sufficient to induce B cell transformation and enables B-myeloid conversion. Blood. PMID 31697816 DOI: 10.1182/Blood.2019001438 |
0.421 |
|
| 2019 |
Lobry C, Bains A, Zamechek LB, Ibrahim S, Aifantis I, Araten DJ. Analysis of mutations in paroxysmal nocturnal hemoglobinuria (PNH). Experimental Hematology & Oncology. 8: 17. PMID 31453016 DOI: 10.1186/S40164-019-0142-0 |
0.305 |
|
| 2019 |
Kloetgen A, Thandapani P, Tsirigos A, Aifantis I. 3D Chromosomal Landscapes in Hematopoiesis and Immunity. Trends in Immunology. PMID 31422902 DOI: 10.1016/J.It.2019.07.003 |
0.546 |
|
| 2019 |
Guillamot M, Ouazia D, Dolgalev I, Yeung ST, Kourtis N, Dai Y, Corrigan K, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Malumbres M, Gong Y, Tsirigos A, ... ... Aifantis I, et al. The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation. Nature Immunology. PMID 31406379 DOI: 10.1038/S41590-019-0454-6 |
0.701 |
|
| 2019 |
Vougas K, Sakelaropoulos T, Kotsinas A, Foukas GP, Ntargaras A, Koinis F, Polyzos A, Myrianthopoulos V, Zhou H, Narang S, Georgoulias V, Alexopoulos L, Aifantis I, Townsend PA, Sfikakis P, et al. Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining. Pharmacology & Therapeutics. 107395. PMID 31374225 DOI: 10.1016/J.Pharmthera.2019.107395 |
0.452 |
|
| 2019 |
Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, ... ... Aifantis I, et al. Author Correction: The bone marrow microenvironment at single-cell resolution. Nature. PMID 31296938 DOI: 10.1038/S41586-019-1394-X |
0.66 |
|
| 2019 |
Chen X, Glytsou C, Zhou H, Narang S, Reyna DE, Lopez A, Sakellaropoulos T, Gong Y, Kloetgen A, Yap YS, Wang E, Gavathiotis E, Tsirigos A, Tibes R, Aifantis I. Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment. Cancer Discovery. PMID 31048321 DOI: 10.1158/2159-8290.Cd-19-0117 |
0.507 |
|
| 2019 |
Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, ... ... Aifantis I, et al. The bone marrow microenvironment at single-cell resolution. Nature. PMID 30971824 DOI: 10.1038/S41586-019-1104-8 |
0.704 |
|
| 2019 |
Brandstadter JD, Perkey E, Gaudette BT, Carrington L, Gomez-Atria D, Blazar BR, Ludewig B, Tikhonova A, Aifantis I, Allman D, Maillard I. Dll1 and Dll4 Notch Ligands Prime T Cell Alloimmunity and Are Expressed in Non-Overlapping Populations of Fibroblastic Stromal Cells in Spleen and Lymph Nodes at the Onset of Gvhd Blood. 134: 588-588. DOI: 10.1182/Blood-2019-123533 |
0.447 |
|
| 2019 |
Muto T, Guillamot M, Fang J, Redondo LZ, Choi K, Gong Y, Walker CS, Hueneman K, Bolanos LC, Barreyro L, Lee L, Greis KD, Khodadadi-Jamayran A, Lujambio A, Lowe SW, ... Aifantis I, et al. Innate Immune Signaling Suppresses Acute Leukemia By Modifying MYC Oncogenic Activity Blood. 134: 727-727. DOI: 10.1182/Blood-2019-121423 |
0.499 |
|
| 2019 |
Witkowski M, Dolgalev I, Evensen N, Roberts K, Sreeram S, Dai Y, Tikhonova A, Loomis C, Mullighan C, Tsirigos A, Carroll W, Aifantis I. 2029 - THE RELAPSED B-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA IMMUNE MICROENVIRONMENT Experimental Hematology. 76: S49. DOI: 10.1016/J.Exphem.2019.06.301 |
0.702 |
|
| 2018 |
Saint Fleur-Lominy S, Maus M, Vaeth M, Lange I, Zee I, Suh D, Liu C, Wu X, Tikhonova A, Aifantis I, Feske S. STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia. Cell Reports. 24: 3045-3060.e5. PMID 30208327 DOI: 10.1016/J.Celrep.2018.08.030 |
0.304 |
|
| 2018 |
Kourtis N, Lazaris C, Hockemeyer K, Balandrán JC, Jimenez AR, Mullenders J, Gong Y, Trimarchi T, Bhatt K, Hu H, Shrestha L, Ambesi-Impiombato A, Kelliher M, Paietta E, Chiosis G, ... ... Aifantis I, et al. Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia. Nature Medicine. PMID 30038221 DOI: 10.1038/S41591-018-0105-8 |
0.624 |
|
| 2018 |
Chakrabarti R, Celià-Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, Hwang J, Peng J, Nixon B, Grady JJ, DeCoste C, Gao J, van Es JH, Li MO, Aifantis I, et al. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science (New York, N.Y.). PMID 29773667 DOI: 10.1126/Science.Aan4153 |
0.422 |
|
| 2018 |
Gong Y, Lazaris C, Sakellaropoulos T, Lozano A, Kambadur P, Ntziachristos P, Aifantis I, Tsirigos A. Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries. Nature Communications. 9: 542. PMID 29416042 DOI: 10.1038/S41467-018-03017-1 |
0.53 |
|
| 2018 |
Teater M, Dominguez PM, Redmond D, Chen Z, Ennishi D, Scott DW, Cimmino L, Ghione P, Chaudhuri J, Gascoyne RD, Aifantis I, Inghirami G, Elemento O, Melnick A, Shaknovich R. AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis. Nature Communications. 9: 222. PMID 29335468 DOI: 10.1038/S41467-017-02595-W |
0.383 |
|
| 2018 |
Austin R, Bywater M, Straube J, Cooper LT, Headlam M, Dave K, Braun M, Bald T, Guimaraes F, Jacquelin S, Witkowski M, Aifantis I, Hill GR, Smyth MJ, Lane SW. Oncogenic-Drivers Dictate Immune Responses to Control Disease Progression in Acute Myeloid Leukaemia Blood. 132: 904-904. DOI: 10.1182/Blood-2018-99-112009 |
0.422 |
|
| 2018 |
Lu SX, Wang E, Pastore A, Xufeng C, Imig J, Lee SC, Ghebrechristos Y, Yoshimi A, Bitner LE, Ki M, Kloetgen A, Lin K, Tibes R, Krainer AR, Uehara T, ... ... Aifantis I, et al. Therapeutic Targeting of an RNA Splicing Factor Network for the Treatment of Myeloid Neoplasms Blood. 132: 427-427. DOI: 10.1182/Blood-2018-99-111430 |
0.446 |
|
| 2018 |
Perkey E, Carrington L, Chung J, Granadier D, Dils A, Friedman A, Tikhonova A, Blazar BR, Koch U, Labrecque N, Radtke F, Siebel C, Aifantis I, Maillard I. Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease Blood. 132: 810-810. DOI: 10.1182/Blood-2018-99-110258 |
0.458 |
|
| 2018 |
Thandapani P, Kloetgen A, Lazaris C, Chen X, Ntziachristos P, Tsirigos A, Aifantis I. Abstract 2998: Dynamic 3d chromosomal landscapes in acute leukemia Cancer Research. 78: 2998-2998. DOI: 10.1158/1538-7445.Am2018-2998 |
0.642 |
|
| 2017 |
Fanok MH, Sun A, Fogli LK, Narendran V, Eckstein M, Kannan K, Dolgalev I, Lazaris C, Heguy A, Laird ME, Sundrud MS, Liu C, Kutok J, Lacruz RS, Latkowski JA, ... Aifantis I, et al. Role of dysregulated cytokine signaling and bacterial triggers in the pathogenesis of Cutaneous T Cell Lymphoma. The Journal of Investigative Dermatology. PMID 29128259 DOI: 10.1016/J.Jid.2017.10.028 |
0.694 |
|
| 2017 |
Thandapani P, Aifantis I. Apoptosis, Up the Ante. Cancer Cell. 32: 402-403. PMID 29017053 DOI: 10.1016/J.Ccell.2017.09.009 |
0.33 |
|
| 2017 |
Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, Ng V, Xia B, Witkowski MT, Mitchell-Flack M, Grillo I, Bakogianni S, Ndiaye-Lobry D, Martín MT, Guillamot M, ... ... Aifantis I, et al. Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell. PMID 28823558 DOI: 10.1016/J.Cell.2017.07.032 |
0.744 |
|
| 2017 |
Gong Y, Huang HT, Liang Y, Trimarchi T, Aifantis I, Tsirigos A. lncRNA-screen: an interactive platform for computationally screening long non-coding RNAs in large genomics datasets. Bmc Genomics. 18: 434. PMID 28583068 DOI: 10.1186/S12864-017-3817-0 |
0.518 |
|
| 2017 |
Aydin IT, Abbate F, Rajan GS, Badal B, Aifantis I, Desman G, Celebi JT. FBXW7 inactivation in a Braf(V600E) -driven mouse model leads to melanoma development. Pigment Cell & Melanoma Research. PMID 28581198 DOI: 10.1111/Pcmr.12603 |
0.32 |
|
| 2017 |
Thandapani P, Aranda-Orgilles B, Aifantis I. RNA-binding proteins, the guardians of the marginal zone. Nature Immunology. 18: 595-597. PMID 28518167 DOI: 10.1038/Ni.3752 |
0.328 |
|
| 2017 |
Pan F, Wingo TS, Zhao Z, Gao R, Makishima H, Qu G, Lin L, Yu M, Ortega JR, Wang J, Nazha A, Chen L, Yao B, Liu C, Chen S, ... ... Aifantis I, et al. Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells. Nature Communications. 8: 15102. PMID 28440315 DOI: 10.1038/Ncomms15102 |
0.418 |
|
| 2017 |
Strikoudis A, Lazaris C, Ntziachristos P, Tsirigos A, Aifantis I. Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex. Cell Cycle (Georgetown, Tex.). 0. PMID 28272987 DOI: 10.1080/15384101.2017.1295194 |
0.628 |
|
| 2017 |
Valls E, Lobry C, Geng H, Wang L, Cardenas M, Rivas M, Cerchietti L, Oh P, Yang SN, Oswald E, Graham CW, Jiang Y, Hatzi K, Agirre X, Perkey E, ... ... Aifantis I, et al. BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells. Cancer Discovery. PMID 28232365 DOI: 10.1158/2159-8290.Cd-16-1189 |
0.789 |
|
| 2017 |
Lazaris C, Kelly S, Ntziachristos P, Aifantis I, Tsirigos A. HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Bmc Genomics. 18: 22. PMID 28056762 DOI: 10.1186/S12864-016-3387-6 |
0.46 |
|
| 2016 |
Carroll WL, Aifantis I, Raetz EA. Beating the Clock in T-Cell Acute Lymphoblastic Leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28007775 DOI: 10.1158/1078-0432.Ccr-16-2825 |
0.388 |
|
| 2016 |
Cimmino L, Aifantis I. Alternative roles for oxidized mCs and TETs. Current Opinion in Genetics & Development. 42: 1-7. PMID 27939598 DOI: 10.1016/J.Gde.2016.11.003 |
0.336 |
|
| 2016 |
Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Wen J, Edmonson M, Payne-Turner D, ... ... Aifantis I, et al. Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. Nature Genetics. PMID 27776115 DOI: 10.1038/Ng.3691 |
0.37 |
|
| 2016 |
Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto AL, Yang Y, Ntziachristos P, Rothbart S, Buckley S, Dolgalev I, Stadtfeld M, Strahl BD, Dynlacht BD, Tsirigos A, Aifantis I. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nature Cell Biology. PMID 27749823 DOI: 10.1038/Ncb3424 |
0.745 |
|
| 2016 |
King B, Boccalatte F, Moran-Crusio K, Wolf E, Wang J, Kayembe C, Lazaris C, Yu X, Aranda-Orgilles B, Lasorella A, Aifantis I. The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells. Nature Immunology. PMID 27668798 DOI: 10.1038/Ni.3559 |
0.414 |
|
| 2016 |
Aranda-Orgilles B, Saldaña-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sánchez-Díaz M, Wang K, Kayembe C, Zhang N, Amoasii L, ... ... Aifantis I, et al. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. PMID 27570068 DOI: 10.1016/J.Stem.2016.08.004 |
0.645 |
|
| 2016 |
Ntziachristos P, Abdel-Wahab O, Aifantis I. Emerging concepts of epigenetic dysregulation in hematological malignancies. Nature Immunology. PMID 27478938 DOI: 10.1038/Ni.3517 |
0.361 |
|
| 2016 |
Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, ... ... Aifantis I, et al. Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. Cancer Cell. PMID 27424808 DOI: 10.1016/J.Ccell.2016.05.018 |
0.334 |
|
| 2016 |
Proudhon C, Snetkova V, Raviram R, Lobry C, Badri S, Jiang T, Hao B, Trimarchi T, Kluger Y, Aifantis I, Bonneau R, Skok JA. Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation. Cell Reports. PMID 27239026 DOI: 10.1016/J.Celrep.2016.04.087 |
0.356 |
|
| 2016 |
Guillamot M, Cimmino L, Aifantis I. The Impact of DNA Methylation in Hematopoietic Malignancies. Trends in Cancer. 2: 70-83. PMID 27019871 DOI: 10.1016/J.Trecan.2015.12.006 |
0.314 |
|
| 2016 |
Bonilla X, Parmentier L, King B, Bezrukov F, Kaya G, Zoete V, Seplyarskiy VB, Sharpe HJ, McKee T, Letourneau A, Ribaux PG, Popadin K, Basset-Seguin N, Chaabene RB, Santoni FA, ... ... Aifantis I, et al. Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma. Nature Genetics. 48: 398-406. PMID 26950094 DOI: 10.1038/Ng.3525 |
0.339 |
|
| 2016 |
Aifantis I. The Impact of 3D Chromosomal Topology in Acute Leukemia Blood. 128: SCI-15-SCI-15. DOI: 10.1182/Blood.V128.22.Sci-15.Sci-15 |
0.458 |
|
| 2016 |
Aranda-Orgilles B, Saldaña-Meyer R, Wang E, Trompouki E, Schrewe H, Tsirigos A, Zon L, Aifantis I. Med12 is an essential regulator of enhancer dynamics in hematopoietic stem cells Experimental Hematology. 44: S57. DOI: 10.1016/J.Exphem.2016.06.086 |
0.606 |
|
| 2015 |
Gao J, Buckley SM, Cimmino L, Guillamot M, Strikoudis A, Cang Y, Goff SP, Aifantis I. The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis. Elife. 4. PMID 26613412 DOI: 10.7554/Elife.07539 |
0.448 |
|
| 2015 |
Mullenders J, Aranda-Orgilles B, Lhoumaud P, Keller M, Pae J, Wang K, Kayembe C, Rocha PP, Raviram R, Gong Y, Premsrirut PK, Tsirigos A, Bonneau R, Skok JA, Cimmino L, ... ... Aifantis I, et al. Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms. The Journal of Experimental Medicine. PMID 26438359 DOI: 10.1084/Jem.20151323 |
0.663 |
|
| 2015 |
Kourtis N, Strikoudis A, Aifantis I. Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond. Current Opinion in Cell Biology. 37: 28-34. PMID 26426760 DOI: 10.1016/J.Ceb.2015.09.003 |
0.45 |
|
| 2015 |
Pitt LA, Tikhonova AN, Hu H, Trimarchi T, King B, Gong Y, Sanchez-Martin M, Tsirigos A, Littman DR, Ferrando AA, Morrison SJ, Fooksman DR, Aifantis I, Schwab SR. CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance. Cancer Cell. 27: 755-68. PMID 26058075 DOI: 10.1016/J.Ccell.2015.05.002 |
0.635 |
|
| 2015 |
Kim E, Ilagan JO, Liang Y, Daubner GM, Lee SC, Ramakrishnan A, Li Y, Chung YR, Micol JB, Murphy ME, Cho H, Kim MK, Zebari AS, Aumann S, Park CY, ... ... Aifantis I, et al. SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition. Cancer Cell. 27: 617-30. PMID 25965569 DOI: 10.1016/J.Ccell.2015.04.006 |
0.35 |
|
| 2015 |
Shih AH, Jiang Y, Meydan C, Shank K, Pandey S, Barreyro L, Antony-Debre I, Viale A, Socci N, Sun Y, Robertson A, Cavatore M, de Stanchina E, Hricik T, Rapaport F, ... ... Aifantis I, et al. Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia. Cancer Cell. 27: 502-15. PMID 25873173 DOI: 10.1016/J.Ccell.2015.03.009 |
0.403 |
|
| 2015 |
Cimmino L, Dawlaty MM, Ndiaye-Lobry D, Yap YS, Bakogianni S, Yu Y, Bhattacharyya S, Shaknovich R, Geng H, Lobry C, Mullenders J, King B, Trimarchi T, Aranda-Orgilles B, Liu C, ... ... Aifantis I, et al. TET1 is a tumor suppressor of hematopoietic malignancy. Nature Immunology. 16: 653-62. PMID 25867473 DOI: 10.1038/Ni.3148 |
0.436 |
|
| 2015 |
Ichiyama K, Chen T, Wang X, Yan X, Kim BS, Tanaka S, Ndiaye-Lobry D, Deng Y, Zou Y, Zheng P, Tian Q, Aifantis I, Wei L, Dong C. The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells. Immunity. 42: 613-26. PMID 25862091 DOI: 10.1016/J.Immuni.2015.03.005 |
0.453 |
|
| 2015 |
Trimarchi T, Aifantis I. The pre-BCR to the rescue: therapeutic targeting of pre-B cell ALL. Cancer Cell. 27: 321-3. PMID 25759017 DOI: 10.1016/J.Ccell.2015.02.012 |
0.376 |
|
| 2015 |
Kourtis N, Moubarak RS, Aranda-Orgilles B, Lui K, Aydin IT, Trimarchi T, Darvishian F, Salvaggio C, Zhong J, Bhatt K, Chen EI, Celebi JT, Lazaris C, Tsirigos A, Osman I, ... ... Aifantis I, et al. FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification. Nature Cell Biology. 17: 322-32. PMID 25720964 DOI: 10.1038/Ncb3121 |
0.598 |
|
| 2015 |
Witkowski MT, Cimmino L, Hu Y, Trimarchi T, Tagoh H, McKenzie MD, Best SA, Tuohey L, Willson TA, Nutt SL, Busslinger M, Aifantis I, Smyth GK, Dickins RA. Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia. Leukemia. 29: 1301-11. PMID 25655195 DOI: 10.1038/Leu.2015.27 |
0.352 |
|
| 2015 |
Danielson LS, Reavie L, Coussens M, Davalos V, Castillo-Martin M, Guijarro MV, Coffre M, Cordon-Cardo C, Aifantis I, Ibrahim S, Liu C, Koralov SB, Hernando E. Limited miR-17-92 overexpression drives hematologic malignancies. Leukemia Research. 39: 335-41. PMID 25597017 DOI: 10.1016/J.Leukres.2014.12.002 |
0.728 |
|
| 2015 |
Gao J, Buckley SM, Cimmino L, Guillamot M, Strikoudis A, Cang Y, Goff SP, Aifantis I. Author response: The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis Elife. DOI: 10.7554/Elife.07539.018 |
0.349 |
|
| 2015 |
Zhang J, McCastlain K, Qu C, Wu G, Edmonson M, Li Y, Wei L, Payne-Turner D, Yoshihara H, Churchman ML, Waanders E, Ntziachristos P, Aifantis I, Roberts KG, Ma J, et al. Expression of an Oncogenic ERG isoform Characterizes a Distinct Subtype of B-Progenitor Acute Lymphoblastic Leukemia Blood. 126: 693-693. DOI: 10.1182/Blood.V126.23.693.693 |
0.387 |
|
| 2015 |
Kim E, Ilagan JO, Lee S, Ramakrishnan A, Chung YR, Micol J, Murphy ME, Kim M, Zebari AS, Buonamici S, Smith P, Deeg HJ, Lobry C, Aifantis I, Bradley RK, et al. Abstract IA36:SRSF2mutations impair hematopoietic differentiation by altering exonic splicing enhancer preference. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-Ia36 |
0.395 |
|
| 2015 |
Aifantis I. Abstract IA24: Regulation of acute leukemia initiation and progression by long noncoding RNAs. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-Ia24 |
0.414 |
|
| 2015 |
Pitt LA, Tikhonova AN, Trimarchi T, King B, Hu H, Gong Y, Tsirigos A, Sanchez-Martin M, Littman DR, Ferrando A, Morrison SJ, Fooksman DR, Aifantis I, Schwab S. Abstract A06: The chemokine receptor CXCR4 is essential for the maintenance of T cell acute lymphoblastic leukemia. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-A06 |
0.644 |
|
| 2015 |
Aifantis I. Abstract IA09: Dynamic regulation of MYC and MYCN ubiquitination Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-Ia09 |
0.48 |
|
| 2015 |
Ichiyama K, Chen T, Wang X, Yan X, Kim BS, Tanaka S, Ndiaye-Lobry D, Deng Y, Zou Y, Zheng P, Tian Q, Aifantis I, Wei L, Dong C. Erratum to The Methylcytosine Dioxygenase Tet2 Promotes DNA Demethylation and Activation of Cytokine Gene Expression in T Cells (Immunity 42, 613-626, 2015) Immunity. 42. DOI: 10.1016/J.Immuni.2015.06.005 |
0.367 |
|
| 2015 |
Aifantis I. Modeling the function of the cohesin complex in hematopoietic stem cell differentiation and transformation Experimental Hematology. 43: S30. DOI: 10.1016/J.Exphem.2015.06.020 |
0.362 |
|
| 2014 |
Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, ... ... Aifantis I, et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Reports. 9: 1841-55. PMID 25482556 DOI: 10.1016/J.Celrep.2014.11.004 |
0.336 |
|
| 2014 |
Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, ... ... Aifantis I, et al. Cyclin C is a haploinsufficient tumour suppressor. Nature Cell Biology. 16: 1080-91. PMID 25344755 DOI: 10.1038/Ncb3046 |
0.358 |
|
| 2014 |
Di Micco R, Fontanals-Cirera B, Low V, Ntziachristos P, Yuen SK, Lovell CD, Dolgalev I, Yonekubo Y, Zhang G, Rusinova E, Gerona-Navarro G, Cañamero M, Ohlmeyer M, Aifantis I, Zhou MM, et al. Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes. Cell Reports. 9: 234-47. PMID 25263550 DOI: 10.1016/J.Celrep.2014.08.055 |
0.739 |
|
| 2014 |
Gough DJ, Marié IJ, Lobry C, Aifantis I, Levy DE. STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation. Blood. 124: 2252-61. PMID 25150294 DOI: 10.1182/Blood-2013-02-484196 |
0.343 |
|
| 2014 |
Ntziachristos P, Tsirigos A, Welstead GG, Trimarchi T, Bakogianni S, Xu L, Loizou E, Holmfeldt L, Strikoudis A, King B, Mullenders J, Becksfort J, Nedjic J, Paietta E, Tallman MS, ... ... Aifantis I, et al. Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia. Nature. 514: 513-7. PMID 25132549 DOI: 10.1038/Nature13605 |
0.599 |
|
| 2014 |
Trimarchi T, Bilal E, Ntziachristos P, Fabbri G, Dalla-Favera R, Tsirigos A, Aifantis I. Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia. Cell. 158: 593-606. PMID 25083870 DOI: 10.1016/J.Cell.2014.05.049 |
0.642 |
|
| 2014 |
Strikoudis A, Guillamot M, Aifantis I. Regulation of stem cell function by protein ubiquitylation. Embo Reports. 15: 365-82. PMID 24652853 DOI: 10.1002/Embr.201338373 |
0.441 |
|
| 2014 |
Ntziachristos P, Lim JS, Sage J, Aifantis I. From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell. 25: 318-34. PMID 24651013 DOI: 10.1016/J.Ccr.2014.02.018 |
0.399 |
|
| 2014 |
Lobry C, Oh P, Mansour MR, Look AT, Aifantis I. Notch signaling: switching an oncogene to a tumor suppressor. Blood. 123: 2451-9. PMID 24608975 DOI: 10.1182/Blood-2013-08-355818 |
0.796 |
|
| 2014 |
Rustighi A, Zannini A, Tiberi L, Sommaggio R, Piazza S, Sorrentino G, Nuzzo S, Tuscano A, Eterno V, Benvenuti F, Santarpia L, Aifantis I, Rosato A, Bicciato S, Zambelli A, et al. Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast. Embo Molecular Medicine. 6: 99-119. PMID 24357640 DOI: 10.1002/Emmm.201302909 |
0.383 |
|
| 2014 |
Kim E, Ilagan JO, Lee S, Ramakrishnan A, Chung YR, Micol J, Murphy ME, Kim M, Zebari AS, Feala J, Buonamici S, Smith PG, Deeg HJ, Lobry C, Aifantis I, et al. SRSF2 Mutations Impair Hematopoietic Differentiation By Altering Exonic Splicing Enhancer Preference Blood. 124: 824-824. DOI: 10.1182/Blood.V124.21.824.824 |
0.386 |
|
| 2014 |
Ntziachristos P, Tsirigos A, Welstead G, Trimarchi T, Holmfeldt L, Satoh T, Paietta EM, Tallman MS, Rowe JM, Tonon G, Becksfort J, Kruidenier L, Prinjha RK, Van Vlierberghe P, Jaenisch R, ... ... Aifantis I, et al. An Oncogene-Regulated Epigenetic Switch in T Cell Acute Lymphoblastic Leukemia Blood. 124: 56-56. DOI: 10.1182/Blood.V124.21.56.56 |
0.673 |
|
| 2013 |
Abdel-Wahab O, Gao J, Adli M, Dey A, Trimarchi T, Chung YR, Kuscu C, Hricik T, Ndiaye-Lobry D, Lafave LM, Koche R, Shih AH, Guryanova OA, Kim E, Li S, ... ... Aifantis I, et al. Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. The Journal of Experimental Medicine. 210: 2641-59. PMID 24218140 DOI: 10.1084/Jem.20131141 |
0.433 |
|
| 2013 |
Poulos MG, Guo P, Kofler NM, Pinho S, Gutkin MC, Tikhonova A, Aifantis I, Frenette PS, Kitajewski J, Rafii S, Butler JM. Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Reports. 4: 1022-34. PMID 24012753 DOI: 10.1016/J.Celrep.2013.07.048 |
0.342 |
|
| 2013 |
Chaumeil J, Micsinai M, Ntziachristos P, Roth DB, Aifantis I, Kluger Y, Deriano L, Skok JA. The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage. Nature Communications. 4: 2231. PMID 23900513 DOI: 10.1038/Ncomms3231 |
0.345 |
|
| 2013 |
Trimarchi T, Ntziachristos P, Aifantis I. A new player SETs in myeloid malignancy. Nature Genetics. 45: 846-7. PMID 23892662 DOI: 10.1038/Ng.2709 |
0.342 |
|
| 2013 |
Oh P, Lobry C, Gao J, Tikhonova A, Loizou E, Manent J, Manet J, van Handel B, Ibrahim S, Greve J, Mikkola H, Artavanis-Tsakonas S, Aifantis I. In vivo mapping of notch pathway activity in normal and stress hematopoiesis. Cell Stem Cell. 13: 190-204. PMID 23791481 DOI: 10.1016/J.Stem.2013.07.009 |
0.782 |
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| 2013 |
King B, Trimarchi T, Reavie L, Xu L, Mullenders J, Ntziachristos P, Aranda-Orgilles B, Perez-Garcia A, Shi J, Vakoc C, Sandy P, Shen SS, Ferrando A, Aifantis I. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell. 153: 1552-66. PMID 23791182 DOI: 10.1016/J.Cell.2013.05.041 |
0.799 |
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| 2013 |
Ntziachristos P, Mullenders J, Trimarchi T, Aifantis I. Mechanisms of epigenetic regulation of leukemia onset and progression. Advances in Immunology. 117: 1-38. PMID 23611284 DOI: 10.1016/B978-0-12-410524-9.00001-3 |
0.356 |
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| 2013 |
Reavie L, Buckley SM, Loizou E, Takeishi S, Aranda-Orgilles B, Ndiaye-Lobry D, Abdel-Wahab O, Ibrahim S, Nakayama KI, Aifantis I. Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. Cancer Cell. 23: 362-75. PMID 23518350 DOI: 10.1016/J.Ccr.2013.01.025 |
0.778 |
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| 2013 |
Chaumeil J, Micsinai M, Ntziachristos P, Deriano L, Wang JM, Ji Y, Nora EP, Rodesch MJ, Jeddeloh JA, Aifantis I, Kluger Y, Schatz DG, Skok JA. Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers. Cell Reports. 3: 359-70. PMID 23416051 DOI: 10.1016/J.Celrep.2013.01.024 |
0.396 |
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| 2013 |
Guy CS, Vignali KM, Temirov J, Bettini ML, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Crawford HC, Aifantis I, Davis MM, et al. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nature Immunology. 14: 262-70. PMID 23377202 DOI: 10.1038/Ni.2538 |
0.383 |
|
| 2013 |
Lobry C, Ntziachristos P, Ndiaye-Lobry D, Oh P, Cimmino L, Zhu N, Araldi E, Hu W, Freund J, Abdel-Wahab O, Ibrahim S, Skokos D, Armstrong SA, Levine RL, Park CY, ... Aifantis I, et al. Notch pathway activation targets AML-initiating cell homeostasis and differentiation. The Journal of Experimental Medicine. 210: 301-19. PMID 23359070 DOI: 10.1084/Jem.20121484 |
0.802 |
|
| 2013 |
Shih AH, Jiang Y, Shank K, Pandey S, Viale A, Sun Y, Socci N, Robertson A, de Stanchina E, Hricik T, Rapaport F, Woods B, Cimmino L, Barreyro L, Steidl U, ... Aifantis I, et al. Epigenetic Profiling Of Leukemia Stem Cells In a Model Of TET2/FLT3-Mutant AML Blood. 122: 476-476. DOI: 10.1182/Blood.V122.21.476.476 |
0.47 |
|
| 2013 |
Poglio S, Bauchet A, Pineda JR, Deswarte C, Leblanc T, Baruchel A, Ballerini P, Landman-Parker J, Aifantis I, Boussin F, Pflumio F. New Design Of Human T-ALL Transplantation In NSG Mice Uncovers The Major Role Of CD31/PECAM1 In The Central Nervous System Infiltration Blood. 122: 1436-1436. DOI: 10.1182/Blood.V122.21.1436.1436 |
0.375 |
|
| 2013 |
Ntziachristos P, Tsirigos A, Trimarchi T, Loizou E, Luyao X, Vlierberghe PV, King B, Welstead G, Mullighan C, Jaenisch R, Ferrando A, Aifantis I. Abstract A07: Characterizing the specific oncogenic and tumor suppressor roles of H3K27me3 epigenetic modulators in T cell leukemia Cancer Research. 73. DOI: 10.1158/1538-7445.Cec13-A07 |
0.679 |
|
| 2012 |
Cimmino L, Aifantis I. Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblastic leukemia. Cancer Discovery. 2: 976-8. PMID 23148371 DOI: 10.1158/2159-8290.Cd-12-0435 |
0.336 |
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| 2012 |
Buckley SM, Aranda-Orgilles B, Strikoudis A, Apostolou E, Loizou E, Moran-Crusio K, Farnsworth CL, Koller AA, Dasgupta R, Silva JC, Stadtfeld M, Hochedlinger K, Chen EI, Aifantis I. Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell. 11: 783-98. PMID 23103054 DOI: 10.1016/J.Stem.2012.09.011 |
0.412 |
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| 2012 |
Tikhonova A, Aifantis I. The taming of the NF-κB: PP4R1 navigates while PP4c dephosphorylates. Immunity. 37: 594-6. PMID 23084354 DOI: 10.1016/J.Immuni.2012.10.006 |
0.375 |
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| 2012 |
Sawai CM, Freund J, Oh P, Ndiaye-Lobry D, Bretz JC, Strikoudis A, Genesca L, Trimarchi T, Kelliher MA, Clark M, Soulier J, Chen-Kiang S, Aifantis I. Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. Cancer Cell. 22: 452-65. PMID 23079656 DOI: 10.1016/J.Ccr.2012.09.016 |
0.776 |
|
| 2012 |
Kallin EM, Rodríguez-Ubreva J, Christensen J, Cimmino L, Aifantis I, Helin K, Ballestar E, Graf T. Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells. Molecular Cell. 48: 266-76. PMID 22981865 DOI: 10.1016/J.Molcel.2012.08.007 |
0.419 |
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| 2012 |
Billiard F, Lobry C, Darrasse-Jèze G, Waite J, Liu X, Mouquet H, DaNave A, Tait M, Idoyaga J, Leboeuf M, Kyratsous CA, Burton J, Kalter J, Klinakis A, Zhang W, ... ... Aifantis I, et al. Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice. The Journal of Experimental Medicine. 209: 1011-28. PMID 22547652 DOI: 10.1084/Jem.20111615 |
0.423 |
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| 2012 |
King B, Ntziachristos P, Aifantis I. Hijacking T cell differentiation: new insights in TLX function in T-ALL. Cancer Cell. 21: 453-5. PMID 22516255 DOI: 10.1016/J.Ccr.2012.03.026 |
0.408 |
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| 2012 |
Moran-Crusio K, Reavie LB, Aifantis I. Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system. Trends in Immunology. 33: 357-63. PMID 22349458 DOI: 10.1016/J.It.2012.01.009 |
0.801 |
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| 2012 |
Ntziachristos P, Tsirigos A, Van Vlierberghe P, Nedjic J, Trimarchi T, Flaherty MS, Ferres-Marco D, da Ros V, Tang Z, Siegle J, Asp P, Hadler M, Rigo I, De Keersmaecker K, Patel J, ... ... Aifantis I, et al. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nature Medicine. 18: 298-301. PMID 22237151 DOI: 10.1038/Nm.2651 |
0.671 |
|
| 2012 |
Abdel-Wahab O, Gao J, Adli M, Chung YR, Koche R, Shih AH, Pandey S, La-Fave LM, Ndiaye-Lobry D, Shin YS, Bhatt PK, Patel JP, Zhao X, Park CY, Jaffe JD, ... ... Aifantis I, et al. Conditional Deletion of Asxl1 Results in Myelodysplasia Blood. 120: 308-308. DOI: 10.1182/Blood.V120.21.308.308 |
0.321 |
|
| 2012 |
Araten DJ, Bains A, Lobry C, Aifantis I, Ibrahim S. A Role for TET2 Mutations in Paroxysmal Nocturnal Hemoglobinuria (PNH) Blood. 120: 1262-1262. DOI: 10.1182/Blood.V120.21.1262.1262 |
0.37 |
|
| 2011 |
Germar K, Dose M, Konstantinou T, Zhang J, Wang H, Lobry C, Arnett KL, Blacklow SC, Aifantis I, Aster JC, Gounari F. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 20060-5. PMID 22109558 DOI: 10.1073/Pnas.1110230108 |
0.465 |
|
| 2011 |
Lobry C, Oh P, Aifantis I. Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. The Journal of Experimental Medicine. 208: 1931-5. PMID 21948802 DOI: 10.1084/Jem.20111855 |
0.787 |
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| 2011 |
Cimmino L, Abdel-Wahab O, Levine RL, Aifantis I. TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell. 9: 193-204. PMID 21885017 DOI: 10.1016/J.Stem.2011.08.007 |
0.42 |
|
| 2011 |
Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, Figueroa ME, Vasanthakumar A, Patel J, Zhao X, Perna F, Pandey S, Madzo J, Song C, Dai Q, ... ... Aifantis I, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 20: 11-24. PMID 21723200 DOI: 10.1016/J.Ccr.2011.06.001 |
0.779 |
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| 2011 |
Mar BG, Amakye D, Aifantis I, Buonamici S. The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis. Leukemia. 25: 1665-73. PMID 21660044 DOI: 10.1038/Leu.2011.143 |
0.442 |
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| 2011 |
Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, Buonamici S, van De Walle I, Cathelin S, Trimarchi T, Araldi E, Liu C, Ibrahim S, Beran M, Zavadil J, Efstratiadis A, ... ... Aifantis I, et al. A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature. 473: 230-3. PMID 21562564 DOI: 10.1038/Nature09999 |
0.808 |
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| 2011 |
D'Altri T, Gonzalez J, Aifantis I, Espinosa L, Bigas A. Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia. Cell Cycle (Georgetown, Tex.). 10: 1031-6. PMID 21389783 DOI: 10.4161/Cc.10.7.15067 |
0.434 |
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| 2011 |
Shmelkov E, Tang Z, Aifantis I, Statnikov A. Assessing quality and completeness of human transcriptional regulatory pathways on a genome-wide scale. Biology Direct. 6: 15. PMID 21356087 DOI: 10.1186/1745-6150-6-15 |
0.355 |
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| 2011 |
Van Vlierberghe P, Patel J, Abdel-Wahab O, Lobry C, Hedvat CV, Balbin M, Nicolas C, Payer AR, Fernandez HF, Tallman MS, Paietta E, Melnick A, Vandenberghe P, Speleman F, Aifantis I, et al. PHF6 mutations in adult acute myeloid leukemia Leukemia. 25: 130-134. PMID 21030981 DOI: 10.1038/Leu.2010.247 |
0.361 |
|
| 2011 |
Aifantis I. The Notch Signaling Pathway as a Suppressor of Myeloid Transformation Blood. 118: SCI-13-SCI-13. DOI: 10.1182/Blood.V118.21.Sci-13.Sci-13 |
0.518 |
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| 2011 |
Mullally A, Poveromo L, Brumme K, Al-Shahrour F, Lane SW, Shih AH, Aifantis I, Levine RL, Ebert BL. Evaluating Clonal Dominance in a Murine Knock-in Model of Jak2V617F MPN Blood. 118: 614-614. DOI: 10.1182/Blood.V118.21.614.614 |
0.417 |
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| 2011 |
Abdel-Wahab O, Adli M, Saunders L, Gao J, Shih AH, Pandey S, Jaffe J, Zhao X, Perna F, Carroll M, Melnick A, Nimer SD, Aifantis I, Bernstein B, Levine RL. ASXL1 Mutations Promote Myeloid Transformation Through Inhibition of PRC2-Mediated Gene Repression Blood. 118: 405-405. DOI: 10.1182/Blood.V118.21.405.405 |
0.455 |
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| 2010 |
Espinosa L, Cathelin S, D'Altri T, Trimarchi T, Statnikov A, Guiu J, Rodilla V, Inglés-Esteve J, Nomdedeu J, Bellosillo B, Besses C, Abdel-Wahab O, Kucine N, Sun SC, Song G, ... ... Aifantis I, et al. The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia Cancer Cell. 18: 268-281. PMID 20832754 DOI: 10.1016/J.Ccr.2010.08.006 |
0.453 |
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| 2010 |
Nedjic J, Aifantis I. RNA-binding proteins come out of the shadows. Nature Immunology. 11: 697-8. PMID 20644579 DOI: 10.1038/Ni0810-697 |
0.407 |
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| 2010 |
Crusio KM, King B, Reavie LB, Aifantis I. The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation. Oncogene. 29: 4865-73. PMID 20543859 DOI: 10.1038/Onc.2010.222 |
0.765 |
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| 2010 |
Reavie L, Della Gatta G, Crusio K, Aranda-Orgilles B, Buckley SM, Thompson B, Lee E, Gao J, Bredemeyer AL, Helmink BA, Zavadil J, Sleckman BP, Palomero T, Ferrando A, Aifantis I. Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nature Immunology. 11: 207-15. PMID 20081848 DOI: 10.1038/Ni.1839 |
0.785 |
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| 2010 |
Aifantis I, Sawai C. Energy addiction and lymphocyte differentiation: a new role for the liver kinase B1 kinase. European Journal of Immunology. 40: 19-21. PMID 20017195 DOI: 10.1002/Eji.200940206 |
0.427 |
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| 2009 |
Gao J, Aifantis I. Hedgehog and hematopoietic stem cell differentiation: don't believe the hype! Cell Cycle (Georgetown, Tex.). 8: 3789-90. PMID 19934654 DOI: 10.4161/Cc.8.23.10107 |
0.412 |
|
| 2009 |
Buonamici S, Trimarchi T, Ruocco MG, Reavie L, Cathelin S, Mar BG, Klinakis A, Lukyanov Y, Tseng JC, Sen F, Gehrie E, Li M, Newcomb E, Zavadil J, Meruelo D, ... ... Aifantis I, et al. CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature. 459: 1000-4. PMID 19536265 DOI: 10.1038/Nature08020 |
0.793 |
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| 2009 |
Gao J, Graves S, Koch U, Liu S, Jankovic V, Buonamici S, El Andaloussi A, Nimer SD, Kee BL, Taichman R, Radtke F, Aifantis I. Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell. 4: 548-58. PMID 19497283 DOI: 10.1016/J.Stem.2009.03.015 |
0.436 |
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| 2009 |
Real PJ, Tosello V, Palomero T, Castillo M, Hernando E, de Stanchina E, Sulis ML, Barnes K, Sawai C, Homminga I, Meijerink J, Aifantis I, Basso G, Cordon-Cardo C, Ai W, et al. Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nature Medicine. 15: 50-8. PMID 19098907 DOI: 10.1038/Nm.1900 |
0.471 |
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| 2008 |
Mandal M, Crusio KM, Meng F, Liu S, Kinsella M, Clark MR, Takeuchi O, Aifantis I. Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid. Proceedings of the National Academy of Sciences of the United States of America. 105: 20840-5. PMID 19088189 DOI: 10.1073/Pnas.0807557106 |
0.459 |
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| 2008 |
Thompson BJ, Jankovic V, Gao J, Buonamici S, Vest A, Lee JM, Zavadil J, Nimer SD, Aifantis I. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. The Journal of Experimental Medicine. 205: 1395-408. PMID 18474632 DOI: 10.1084/Jem.20080277 |
0.464 |
|
| 2008 |
Aifantis I, Raetz E, Buonamici S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nature Reviews. Immunology. 8: 380-90. PMID 18421304 DOI: 10.1038/Nri2304 |
0.42 |
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| 2008 |
Johnson K, Hashimshony T, Sawai CM, Pongubala JM, Skok JA, Aifantis I, Singh H. Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. Immunity. 28: 335-45. PMID 18280186 DOI: 10.1016/J.Immuni.2007.12.019 |
0.393 |
|
| 2008 |
Buonamici S, Aifantis I. Hexamethylene bisacetamide as a treatment for T-cell leukemia (T-ALL). Leukemia Research. 32: 689-90. PMID 18164760 DOI: 10.1016/J.Leukres.2007.11.018 |
0.44 |
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| 2008 |
Real PJ, Tosello V, Palomero T, Castillo M, Sawai C, Sulis ML, Meijerink JP, Basso G, Aifantis I, Cordon-Cardo C, Ferrando AA. Inhibition of NOTCH1 Signaling and Glucocorticoid Therapy in T-ALL Blood. 112: 298-298. DOI: 10.1182/Blood.V112.11.298.298 |
0.452 |
|
| 2008 |
Buonamici S, Trimarchi T, Klinakis A, Reavie L, Mar BG, Gehrie E, Kuan EL, Randolph GJ, Bromberg J, Aifantis I. Knockdown of CCR7 or Its Ligands Causes a Loss of Central Nervous System Involvement in Notch1 Induced T-ALL Blood. 112: 199-199. DOI: 10.1182/Blood.V112.11.199.199 |
0.792 |
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| 2007 |
Thompson BJ, Buonamici S, Sulis ML, Palomero T, Vilimas T, Basso G, Ferrando A, Aifantis I. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. The Journal of Experimental Medicine. 204: 1825-35. PMID 17646408 DOI: 10.1084/Jem.20070872 |
0.423 |
|
| 2007 |
Aifantis I, Vilimas T, Buonamici S. Notches, NFkappaBs and the making of T cell leukemia. Cell Cycle (Georgetown, Tex.). 6: 403-6. PMID 17329966 DOI: 10.4161/Cc.6.4.3858 |
0.451 |
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| 2007 |
Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, Thompson B, Spaulding C, Macaroun S, Alegre ML, Kee BL, Ferrando A, Miele L, Aifantis I. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nature Medicine. 13: 70-7. PMID 17173050 DOI: 10.1038/Nm1524 |
0.455 |
|
| 2007 |
Buonamici S, Thompson BJ, Sulis ML, Palomero T, Ferrando A, Aifantis I. FBW7 E3-Ligase Mutations Are Associated with T Cell Leukemia. Blood. 110: 4284-4284. DOI: 10.1182/Blood.V110.11.4284.4284 |
0.41 |
|
| 2006 |
Scimone ML, Aifantis I, Apostolou I, von Boehmer H, von Andrian UH. A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. Proceedings of the National Academy of Sciences of the United States of America. 103: 7006-11. PMID 16641096 DOI: 10.1073/Pnas.0602024103 |
0.361 |
|
| 2006 |
El Andaloussi A, Graves S, Meng F, Mandal M, Mashayekhi M, Aifantis I. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nature Immunology. 7: 418-26. PMID 16518394 DOI: 10.1038/ni1313 |
0.363 |
|
| 2006 |
Reschly EJ, Spaulding C, Vilimas T, Graham WV, Brumbaugh RL, Aifantis I, Pear WS, Kee BL. Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms. Blood. 107: 4115-21. PMID 16449526 DOI: 10.1182/Blood-2005-09-3551 |
0.464 |
|
| 2006 |
Aifantis I, Mandal M, Sawai K, Ferrando A, Vilimas T. Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor. Immunological Reviews. 209: 159-69. PMID 16448541 DOI: 10.1111/j.0105-2896.2006.00343.x |
0.352 |
|
| 2005 |
Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, Von Boehmer H, Aifantis I. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival Journal of Experimental Medicine. 201: 603-614. PMID 15728238 DOI: 10.1084/Jem.20041924 |
0.311 |
|
| 2003 |
von Boehmer H, Aifantis I, Gounari F, Azogui O, Haughn L, Apostolou I, Jaeckel E, Grassi F, Klein L. Thymic selection revisited: how essential is it? Immunological Reviews. 191: 62-78. PMID 12614352 |
0.306 |
|
| 2002 |
Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nature Immunology. 3: 483-8. PMID 11927911 DOI: 10.1038/ni779 |
0.328 |
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| 2002 |
Borowski C, Martin C, Gounari F, Haughn L, Aifantis I, Grassi F, von Boehmer H. On the brink of becoming a T cell. Current Opinion in Immunology. 14: 200-6. PMID 11869893 |
0.356 |
|
| 1999 |
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B. The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development. The Journal of Experimental Medicine. 189: 563-74. PMID 9927518 DOI: 10.1084/Jem.189.3.563 |
0.348 |
|
| 1997 |
Buer J, Aifantis I, DiSanto JP, Fehling HJ, von Boehmer H. Role of different T cell receptors in the development of pre-T cells. The Journal of Experimental Medicine. 185: 1541-7. PMID 9151891 DOI: 10.1084/Jem.185.9.1541 |
0.355 |
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