| Year |
Citation |
Score |
| 2017 |
Ahmad MF, Alam I, Huff SE, Pink J, Flanagan SA, Shewach D, Misko TA, Oleinick NL, Harte WE, Viswanathan R, Harris ME, Dealwis CG. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proceedings of the National Academy of Sciences of the United States of America. PMID 28716944 DOI: 10.1073/Pnas.1620220114 |
0.437 |
|
| 2017 |
Nikiforov MA, Shewach DS. Detection of Nucleotide Disbalance in Cells Undergoing Oncogene-Induced Senescence. Methods in Molecular Biology (Clifton, N.J.). 1534: 165-173. PMID 27812878 DOI: 10.1007/978-1-4939-6670-7_16 |
0.569 |
|
| 2016 |
Im MM, Flanagan SA, Ackroyd JJ, Knapp B, Kramer A, Shewach DS. Late DNA Damage Mediated by Homologous Recombination Repair Results in Radiosensitization with Gemcitabine. Radiation Research. PMID 27740890 DOI: 10.1667/Rr14443.1 |
0.506 |
|
| 2016 |
Bianchi-Smiraglia A, Bagati A, Fink EE, Moparthy S, Wawrzyniak JA, Marvin EK, Battaglia S, Jowdy P, Kolesnikova M, Foley CE, Berman AE, Kozlova NI, Lipchick BC, Paul-Rosner LM, Bshara W, ... ... Shewach DS, et al. Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools. Oncogene. PMID 27181209 DOI: 10.1038/Onc.2016.178 |
0.411 |
|
| 2016 |
Flanagan SA, Ackroyd JJ, Kramer A, Feigin J, Shewach DS. Abstract 2999: Cytotoxicity with hydroxamic acid HDACis in combination with antimetabolites is highly sequence dependent in solid tumor cells Cancer Research. 76: 2999-2999. DOI: 10.1158/1538-7445.Am2016-2999 |
0.512 |
|
| 2015 |
Lamm N, Maoz K, Bester AC, Im MM, Shewach DS, Karni R, Kerem B. Folate levels modulate oncogene-induced replication stress and tumorigenicity. Embo Molecular Medicine. 7: 1138-52. PMID 26197802 DOI: 10.15252/Emmm.201404824 |
0.349 |
|
| 2015 |
Bianchi-Smiraglia A, Wawrzyniak JA, Bagati A, Marvin EK, Ackroyd J, Moparthy S, Bshara W, Fink EE, Foley CE, Morozevich GE, Berman AE, Shewach DS, Nikiforov MA. Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity. Cell Death and Differentiation. PMID 25909885 DOI: 10.1038/Cdd.2015.47 |
0.368 |
|
| 2015 |
Im MM, Flanagan SA, Ackroyd JJ, Shewach DS. Drug metabolism and homologous recombination repair in radiosensitization with gemcitabine. Radiation Research. 183: 114-23. PMID 25564718 DOI: 10.1667/Rr13807.1 |
0.579 |
|
| 2015 |
Flanagan SA, Ackroyd J, Shewach DS. Abstract 2553: Gemcitabine fails to radiosensitize normal intestinal epithelial CCD841 cells at concentrations that promote excellent radiosensitization in colorectal tumor cell lines Cancer Research. 75: 2553-2553. DOI: 10.1158/1538-7445.Am2015-2553 |
0.431 |
|
| 2014 |
Ruch RJ, Boucher PD, Gentry BG, Shewach DS. Gap Junctional Intercellular Communication Increases Cytotoxicity and Reduces Resistance to Hydroxyurea Journal of Cancer Therapy. 5: 1190-1202. DOI: 10.4236/Jct.2014.513121 |
0.785 |
|
| 2014 |
Flanagan SA, Ackroyd JJ, Mannava S, Nikiforov MA, Shewach DS. Abstract 847: Suppression of p53R2 but not R2 radiosensitizes mutant p53 tumor cells Cancer Research. 74: 847-847. DOI: 10.1158/1538-7445.Am2014-847 |
0.479 |
|
| 2013 |
Ladd B, Ackroyd JJ, Hicks JK, Canman CE, Flanagan SA, Shewach DS. Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity. Dna Repair. 12: 1114-21. PMID 24231389 DOI: 10.1016/J.Dnarep.2013.10.008 |
0.841 |
|
| 2013 |
Wawrzyniak JA, Bianchi-Smiraglia A, Bshara W, Mannava S, Ackroyd J, Bagati A, Omilian AR, Im M, Fedtsova N, Miecznikowski JC, Moparthy KC, Zucker SN, Zhu Q, Kozlova NI, Berman AE, ... ... Shewach DS, et al. A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion. Cell Reports. 5: 493-507. PMID 24139804 DOI: 10.1016/J.Celrep.2013.09.015 |
0.403 |
|
| 2013 |
Mannava S, Moparthy KC, Wheeler LJ, Natarajan V, Zucker SN, Fink EE, Im M, Flanagan S, Burhans WC, Zeitouni NC, Shewach DS, Mathews CK, Nikiforov MA. Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence. The American Journal of Pathology. 182: 142-51. PMID 23245831 DOI: 10.1016/J.Ajpath.2012.09.011 |
0.537 |
|
| 2013 |
Flanagan SA, Cooper K, Mannava S, Nikiforov M, Shewach DS. Abstract 445: shRNA mediated suppression of either of the small subunits of ribonucleotide reductase, R2 and p53R2, elicits a robust increase in sensitivity to ionizing radiation. Cancer Research. 73: 445-445. DOI: 10.1158/1538-7445.Am2013-445 |
0.456 |
|
| 2012 |
Mannava S, Moparthy KC, Wheeler LJ, Leonova KI, Wawrzyniak JA, Bianchi-Smiraglia A, Berman AE, Flanagan S, Shewach DS, Zeitouni NC, Gudkov AV, Mathews CK, Nikiforov MA. Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion. Aging. 4: 917-22. PMID 23249808 |
0.451 |
|
| 2012 |
Flanagan SA, Cooper KS, Mannava S, Nikiforov MA, Shewach DS. Short hairpin RNA suppression of thymidylate synthase produces DNA mismatches and results in excellent radiosensitization. International Journal of Radiation Oncology, Biology, Physics. 84: e613-20. PMID 22867891 DOI: 10.1016/J.Ijrobp.2012.06.050 |
0.377 |
|
| 2011 |
Ladd B, O'Konek JJ, Ostruszka LJ, Shewach DS. Unrepairable DNA double-strand breaks initiate cytotoxicity with HSV-TK/ganciclovir. Cancer Gene Therapy. 18: 751-9. PMID 21869826 DOI: 10.1038/Cgt.2011.51 |
0.761 |
|
| 2011 |
Bester AC, Roniger M, Oren YS, Im MM, Sarni D, Chaoat M, Bensimon A, Zamir G, Shewach DS, Kerem B. Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell. 145: 435-46. PMID 21529715 DOI: 10.1016/J.Cell.2011.03.044 |
0.478 |
|
| 2011 |
Medina SH, Tekumalla V, Chevliakov MV, Shewach DS, Ensminger WD, El-Sayed ME. N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers. Biomaterials. 32: 4118-29. PMID 21429574 DOI: 10.1016/J.Biomaterials.2010.11.068 |
0.355 |
|
| 2011 |
Ladd B, Shewach DS. Abstract 5374: Synergistic tumor cell killing with ganciclovir and vorinostat is due to inhibition of homologous recombination Cancer Research. 71: 5374-5374. DOI: 10.1158/1538-7445.Am2011-5374 |
0.844 |
|
| 2010 |
O'Konek JJ, Ladd B, Flanagan SA, Im MM, Boucher PD, Thepsourinthone TS, Secrist JA, Shewach DS. Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity. Mutation Research. 684: 1-10. PMID 20004674 DOI: 10.1016/J.Mrfmmm.2009.11.011 |
0.828 |
|
| 2010 |
Flanagan SA, Nikiforov MA, Mannava S, Shewach DS. Abstract 1390: shRNA mediated suppression of thymidylate synthase results in an increased sensitivity to ionizing radiation similar to 5-fluoro-2′-deoxyuridine Cancer Research. 70: 1390-1390. DOI: 10.1158/1538-7445.Am10-1390 |
0.529 |
|
| 2010 |
Im MM, Flanagan SA, Ladd BP, Shewach DS. Abstract 1316: Late-occurring DNA damage is responsible for radiosensitization with gemcitabine Cancer Research. 70: 1316-1316. DOI: 10.1158/1538-7445.Am10-1316 |
0.82 |
|
| 2009 |
O'Konek JJ, Boucher PD, Iacco AA, Wilson TE, Shewach DS. MLH1 deficiency enhances tumor cell sensitivity to ganciclovir. Cancer Gene Therapy. 16: 683-92. PMID 19300472 DOI: 10.1038/Cgt.2009.16 |
0.796 |
|
| 2008 |
Mannava S, Grachtchouk V, Wheeler LJ, Im M, Zhuang D, Slavina EG, Mathews CK, Shewach DS, Nikiforov MA. Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells. Cell Cycle (Georgetown, Tex.). 7: 2392-400. PMID 18677108 DOI: 10.4161/Cc.6390 |
0.405 |
|
| 2008 |
Flanagan SA, Krokosky CM, Mannava S, Nikiforov MA, Shewach DS. MLH1 deficiency enhances radiosensitization with 5-fluorodeoxyuridine by increasing DNA mismatches. Molecular Pharmacology. 74: 863-71. PMID 18535288 DOI: 10.1124/Mol.107.043349 |
0.571 |
|
| 2007 |
Shewach DS, Lawrence TS. Antimetabolite radiosensitizers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 25: 4043-50. PMID 17827452 DOI: 10.1200/JCO.2007.11.5287 |
0.371 |
|
| 2007 |
Flanagan SA, Robinson BW, Krokosky CM, Shewach DS. Mismatched nucleotides as the lesions responsible for radiosensitization with gemcitabine: a new paradigm for antimetabolite radiosensitizers. Molecular Cancer Therapeutics. 6: 1858-68. PMID 17575114 DOI: 10.1158/1535-7163.Mct-07-0068 |
0.772 |
|
| 2006 |
Gentry BG, Boucher PD, Shewach DS. Hydroxyurea induces bystander cytotoxicity in cocultures of herpes simplex virus thymidine kinase-expressing and nonexpressing HeLa cells incubated with ganciclovir Cancer Research. 66: 3845-3851. PMID 16585212 DOI: 10.1158/0008-5472.Can-05-3660 |
0.802 |
|
| 2006 |
Boucher PD, Im MM, Freytag SO, Shewach DS. A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy. Cancer Research. 66: 3230-7. PMID 16540675 DOI: 10.1158/0008-5472.Can-05-3033 |
0.467 |
|
| 2005 |
Boucher PD, Shewach DS. In vitro and in vivo enhancement of ganciclovir-mediated bystander cytotoxicity with gemcitabine. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 1064-71. PMID 16107324 DOI: 10.1016/J.Ymthe.2005.07.643 |
0.547 |
|
| 2005 |
Gentry BG, Im M, Boucher PD, Ruch RJ, Shewach DS. GCV phosphates are transferred between HeLa cells despite lack of bystander cytotoxicity Gene Therapy. 12: 1033-1041. PMID 15789060 DOI: 10.1038/Sj.Gt.3302487 |
0.786 |
|
| 2005 |
Gentry BG, Boucher PD, Shewach DS. 807. Addition of HU to GCV Induces Bystander Cytotoxicity in Co-Cultures of HSVTK-Expressing and Non-Expressing HeLa Cells Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.344 |
0.787 |
|
| 2004 |
Robinson BW, Ostruszka L, Im MM, Shewach DS. Promising combination therapies with gemcitabine. Seminars in Oncology. 31: 2-12. PMID 15199526 DOI: 10.1053/J.Seminoncol.2004.03.021 |
0.809 |
|
| 2004 |
Leu KM, Ostruszka LJ, Shewach D, Zalupski M, Sondak V, Biermann JS, Lee JS, Couwlier C, Palazzolo K, Baker LH. Laboratory and clinical evidence of synergistic cytotoxicity of sequential treatment with gemcitabine followed by docetaxel in the treatment of sarcoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 1706-12. PMID 15117993 DOI: 10.1200/Jco.2004.08.043 |
0.766 |
|
| 2004 |
Boucher PD, O'Konek J, Freytag SO, Shewach DS. 1033. A Novel Mechanism of Synergistic Cytoxicity between Prodrugs, 5-FC and GCV in Double Suicide Gene Therapy Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.978 |
0.771 |
|
| 2003 |
Robinson BW, Im MM, Ljungman M, Praz F, Shewach DS. Enhanced radiosensitization with gemcitabine in mismatch repair-deficient HCT116 cells. Cancer Research. 63: 6935-41. PMID 14583494 |
0.776 |
|
| 2003 |
Ostruszka LJ, Shewach DS. The role of DNA synthesis inhibition in the cytotoxicity of 2',2'-difluoro-2'-deoxycytidine. Cancer Chemotherapy and Pharmacology. 52: 325-32. PMID 12811514 DOI: 10.1007/S00280-003-0661-5 |
0.806 |
|
| 2002 |
Fernstrom MJ, Koffler LD, Abou-Rjaily G, Boucher PD, Shewach DS, Ruch RJ. Neoplastic reversal of human ovarian carcinoma cells transfected with connexin43. Experimental and Molecular Pathology. 73: 54-60. PMID 12127054 DOI: 10.1006/Exmp.2002.2436 |
0.451 |
|
| 2002 |
Boucher PD, Ostruszka LJ, Murphy PJ, Shewach DS. Hydroxyurea significantly enhances tumor growth delay in vivo with herpes simplex virus thymidine kinase/ganciclovir gene therapy. Gene Therapy. 9: 1023-30. PMID 12101433 DOI: 10.1038/Sj.Gt.3301730 |
0.8 |
|
| 2002 |
Shewach DS, Murphy PJ, Robinson BW, Vuletich J, Boucher PD, Blobaum AL, Zerbe L, Secrist JA, Parker WB. Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells. Human Gene Therapy. 13: 543-51. PMID 11874632 DOI: 10.1089/10430340252809838 |
0.796 |
|
| 2001 |
Robinson BW, Shewach DS. Radiosensitization by gemcitabine in p53 wild-type and mutant MCF-7 breast carcinoma cell lines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 2581-9. PMID 11489842 |
0.755 |
|
| 2001 |
Eisbruch A, Shewach DS, Bradford CR, Littles JF, Teknos TN, Chepeha DB, Marentette LJ, Terrell JE, Hogikyan ND, Dawson LA, Urba S, Wolf GT, Lawrence TS. Radiation concurrent with gemcitabine for locally advanced head and neck cancer: a phase I trial and intracellular drug incorporation study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 19: 792-9. PMID 11157033 DOI: 10.1200/Jco.2001.19.3.792 |
0.316 |
|
| 2000 |
Parker WB, Shaddix SC, Rose LM, Waud WR, Shewach DS, Tiwari KN, Secrist JA. Metabolism of 4'-thio-β-d-arabinofuranosylcytosine in CEM cells Biochemical Pharmacology. 60: 1925-1932. PMID 11108809 DOI: 10.1016/S0006-2952(00)00520-7 |
0.314 |
|
| 2000 |
Ostruszka LJ, Shewach DS. The role of cell cycle progression in radiosensitization by 2',2'-difluoro-2'-deoxycytidine. Cancer Research. 60: 6080-8. PMID 11085531 |
0.82 |
|
| 2000 |
Boucher PD, Ostruszka LJ, Shewach DS. Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir-mediated cytoxicity by hydroxyurea. Cancer Research. 60: 1631-6. PMID 10749133 |
0.822 |
|
| 1998 |
Bennett LL, Allan PW, Arnett G, Shealy YF, Shewach DS, Mason WS, Fourel I, Parker WB. Metabolism in human cells of the D and L enantiomers of the carbocyclic analog of 2'-deoxyguanosine: substrate activity with deoxycytidine kinase, mitochondrial deoxyguanosine kinase, and 5'-nucleotidase. Antimicrobial Agents and Chemotherapy. 42: 1045-51. PMID 9593124 DOI: 10.1128/Aac.42.5.1045 |
0.355 |
|
| 1998 |
Boucher PD, Ruch RJ, Shewach DS. Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase. Human Gene Therapy. 9: 801-14. PMID 9581903 DOI: 10.1089/Hum.1998.9.6-801 |
0.474 |
|
| 1998 |
Rubsam LZ, Shewach DS. Improved method to prepare RNA-free DNA from mammalian cells. Journal of Chromatography. B, Biomedical Sciences and Applications. 702: 61-8. PMID 9449556 DOI: 10.1016/S0378-4347(97)00379-4 |
0.342 |
|
| 1997 |
Hughes TL, Hahn TM, Reynolds KK, Shewach DS. Kinetic analysis of human deoxycytidine kinase with the true phosphate donor uridine triphosphate. Biochemistry. 36: 7540-7. PMID 9200705 DOI: 10.1021/Bi970059R |
0.326 |
|
| 1997 |
Shewach DS, Lawrence TS. Gemcitabine and radiosensitization in human tumor cells. Investigational New Drugs. 14: 257-63. PMID 8958180 DOI: 10.1007/Bf00194528 |
0.575 |
|
| 1996 |
Plumb TJ, Bosch A, Roessler BJ, Shewach DS, Davidson BL. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer. Neuroscience Letters. 214: 159-62. PMID 8878108 DOI: 10.1016/0304-3940(96)12932-3 |
0.33 |
|
| 1996 |
McGinn CJ, Shewach DS, Lawrence TS. Radiosensitizing nucleosides Journal of the National Cancer Institute. 88: 1193-1203. PMID 8780628 DOI: 10.1093/jnci/88.17.1193 |
0.307 |
|
| 1996 |
Robertson JM, Shewach DS, Lawrence TS. Preclinical studies of chemotherapy and radiation therapy for pancreatic carcinoma. Cancer. 78: 674-9. PMID 8681306 DOI: 10.1002/(Sici)1097-0142(19960801)78:3<674::Aid-Cncr48>3.0.Co;2-T |
0.311 |
|
| 1996 |
Lawrence TS, Chang EY, Hahn TM, Hertel LW, Shewach DS. Radiosensitization of pancreatic cancer cells by 2',2'-difluoro-2'-deoxycytidine. International Journal of Radiation Oncology, Biology, Physics. 34: 867-72. PMID 8598364 DOI: 10.1016/0360-3016(95)02134-5 |
0.355 |
|
| 1993 |
Shewach DS, Liotta DC, Schinazi RF. Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinase. Biochemical Pharmacology. 45: 1540-3. PMID 8385948 DOI: 10.1016/0006-2952(93)90058-5 |
0.311 |
|
| 1992 |
Shewach DS, Ellero J, Mancini WR, Ensminger WD. Decrease in TTP pools mediated by 5-bromo-2'-deoxyuridine exposure in a human glioblastoma cell line. Biochemical Pharmacology. 43: 1579-85. PMID 1567479 DOI: 10.1016/0006-2952(92)90217-7 |
0.57 |
|
| 1992 |
Shewach DS, Krawczyk SH, Acevedo OL, Townsend LB. Inhibition of adenosine deaminase by azapurine ribonucleosides. Biochemical Pharmacology. 44: 1697-700. PMID 1449528 DOI: 10.1016/0006-2952(92)90061-M |
0.309 |
|
| 1991 |
Bruso CE, Shewach DS, Lawrence TS. Fluorodeoxyuridine-induced radiosensitization and inhibition of DNA double strand break repair in human colon cancer cells. International Journal of Radiation Oncology, Biology, Physics. 19: 1411-7. PMID 2148170 DOI: 10.1016/0360-3016(90)90352-K |
0.547 |
|
| 1991 |
Chottiner EG, Shewach DS, Datta NS, Ashcraft E, Gribbin D, Ginsburg D, Fox IH, Mitchell BS. Cloning and expression of human deoxycytidine kinase cDNA. Proceedings of the National Academy of Sciences of the United States of America. 88: 1531-5. PMID 1996353 DOI: 10.1073/Pnas.88.4.1531 |
0.335 |
|
| 1991 |
Lawrence TS, Heimburger DK, Shewach DS. The effects of leucovorin and dipyridamole on fluoropyrimidine-induced radiosensitization. International Journal of Radiation Oncology, Biology, Physics. 20: 377-81. PMID 1991704 DOI: 10.1016/0360-3016(91)90124-M |
0.461 |
|
| 1991 |
Heimburger DK, Shewach DS, Lawrence TS. The effect of fluorodeoxyuridine on sublethal damage repair in human colon cancer cells. International Journal of Radiation Oncology, Biology, Physics. 21: 983-7. PMID 1833363 DOI: 10.1016/0360-3016(91)90739-Q |
0.523 |
|
| 1988 |
Shewach DS, Mitchell BS. 90 METABOLISM OF GUANINE ARABINOSIDE AND CYTOSINE ARABINOSIDE IN CELLS FROM PATIENTS WITH LEUKEMIA Pediatric Research. 24: 126-126. DOI: 10.1203/00006450-198807000-00114 |
0.432 |
|
| 1986 |
Shewach DS, Mitchell BS. Characterization of arabinosylguanine resistance in a lymphoblastoid cell line. Advances in Experimental Medicine and Biology. 605-9. PMID 3094330 DOI: 10.1007/978-1-4684-1248-2_94 |
0.408 |
|
| 1985 |
Daddona PE, Orkin SH, Shewach DS, Kelley WN. cDNA and amino acid sequence of human adenosine deaminase. Annals of the New York Academy of Sciences. 451: 238-44. PMID 3878119 DOI: 10.1111/J.1749-6632.1985.Tb27114.X |
0.339 |
|
| 1985 |
Shewach DS, Mitchell BS. CHARACTERIZATION OF ARABINOSYLGUANINE (AraG) RESISTANCE IN A LYMPHOBLASTOID CELL LINE: 188 Pediatric Research. 19: 775-775. DOI: 10.1203/00006450-198507000-00208 |
0.472 |
|
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