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Steven A. Prescott - Publications

Affiliations: 
2008-2012 Neurobiology University of Pittsburgh, Pittsburgh, PA, United States 
 2012- Physiology University of Toronto, Toronto, ON, Canada 
Area:
Computational Neuroscience, Pain
Website:
http://www.sickkids.ca/AboutSickKids/Directory/People/P/steve-prescott-staff-profile.html
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Medlock L, Al-Basha D, Halawa A, Dedek C, Ratté S, Prescott SA. Encoding of vibrotactile stimuli by mechanoreceptors in rodent glabrous skin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 39379153 DOI: 10.1523/JNEUROSCI.1252-24.2024  0.656
2024 Xie YF, Yang J, Ratté S, Prescott SA. Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs. Elife. 12. PMID 38687187 DOI: 10.7554/eLife.90960  0.685
2024 Gradwell MA, Ozeri-Engelhard N, Eisdorfer JT, Laflamme OD, Gonzalez M, Upadhyay A, Medlock L, Shrier T, Patel KR, Aoki A, Gandhi M, Abbas-Zadeh G, Oputa O, Thackray JK, Ricci M, ... ... Prescott SA, et al. Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn. Neuron. PMID 38452762 DOI: 10.1016/j.neuron.2024.01.027  0.781
2023 Sagalajev B, Zhang T, Abdollahi N, Yousefpour N, Medlock L, Al-Basha D, Ribeiro-da-Silva A, Esteller R, Ratté S, Prescott SA. Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation. Neuron. PMID 37972595 DOI: 10.1016/j.neuron.2023.10.021  0.774
2023 Rezaei MR, Saadati Fard R, Popovic MR, Prescott SA, Lankarany M. Synchrony-Division Neural Multiplexing: An Encoding Model. Entropy (Basel, Switzerland). 25. PMID 37190377 DOI: 10.3390/e25040589  0.777
2022 Kamaleddin MA, Shifman A, Abdollahi N, Sigal D, Ratté S, Prescott SA. Physiological noise facilitates multiplexed coding of vibrotactile-like signals in somatosensory cortex. Proceedings of the National Academy of Sciences of the United States of America. 119: e2118163119. PMID 36067307 DOI: 10.1073/pnas.2118163119  0.733
2022 Yang J, Shakil H, Ratté S, Prescott SA. Minimal requirements for a neuron to coregulate many properties and the implications for ion channel correlations and robustness. Elife. 11. PMID 35293858 DOI: 10.7554/eLife.72875  0.658
2022 Medlock L, Sekiguchi K, Hong S, Dura-Bernal S, Lytton WW, Prescott SA. Multiscale Computer Model of the Spinal Dorsal Horn Reveals Changes in Network Processing Associated with Chronic Pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 42: 3133-3149. PMID 35232767 DOI: 10.1523/JNEUROSCI.1199-21.2022  0.806
2019 Lee KY, Ratté S, Prescott SA. Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn. Elife. 8. PMID 31742556 DOI: 10.7554/eLife.49753  0.778
2019 Al-Basha D, Prescott SA. Intermittent Failure of Spike Propagation in Primary Afferent Neurons during Tactile Stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31672792 DOI: 10.1523/JNEUROSCI.0975-19.2019  0.357
2019 Mapplebeck JCS, Lorenzo LE, Lee KY, Gauthier C, Muley MM, De Koninck Y, Prescott SA, Salter MW. Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes. Cell Reports. 28: 590-596.e4. PMID 31315039 DOI: 10.1016/J.Celrep.2019.06.059  0.741
2019 Lankarany M, Al-Basha D, Ratté S, Prescott SA. Differentially synchronized spiking enables multiplexed neural coding. Proceedings of the National Academy of Sciences of the United States of America. PMID 31028148 DOI: 10.1073/Pnas.1812171116  0.824
2019 FallahRad M, Zannou AL, Khadka N, Prescott SA, Ratté S, Zhang T, Esteller R, Hershey B, Bikson M. Topical Review: Electrophysiology equipment for reliable study of kHz electrical stimulation. The Journal of Physiology. PMID 30816558 DOI: 10.1113/Jp277654  0.662
2019 Lee KY, Ratté S, Prescott SA. Author response: Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn Elife. DOI: 10.7554/Elife.49753.Sa2  0.51
2018 Mousseau M, Burma NE, Lee KY, Leduc-Pessah H, Kwok CHT, Reid AR, O'Brien M, Sagalajev B, Stratton JA, Patrick N, Stemkowski PL, Biernaskie J, Zamponi GW, Salo P, McDougall JJ, ... Prescott SA, et al. Microglial pannexin-1 channel activation is a spinal determinant of joint pain. Science Advances. 4: eaas9846. PMID 30101191 DOI: 10.1126/Sciadv.Aas9846  0.41
2018 Mouchbahani-Constance S, Lesperance LS, Petitjean H, Davidova A, Macpherson A, Prescott SA, Sharif-Naeini R. Lionfish Venom Elicits Pain Predominantly Through the Activation of Non-Peptidergic Nociceptors. Pain. PMID 29965829 DOI: 10.1097/J.Pain.0000000000001326  0.384
2018 Wang F, Bélanger E, Côté SL, Desrosiers P, Prescott SA, Côté DC, De Koninck Y. Sensory Afferents Use Different Coding Strategies for Heat and Cold. Cell Reports. 23: 2001-2013. PMID 29768200 DOI: 10.1016/J.Celrep.2018.04.065  0.76
2018 Takkala P, Prescott SA. Using dynamic clamp to quantify pathological changes in the excitability of primary somatosensory neurons. The Journal of Physiology. PMID 29601637 DOI: 10.1113/Jp275580  0.807
2018 Balachandar A, Prescott SA. Origin of heterogeneous spiking patterns from continuously distributed ion channel densities: a computational study in spinal dorsal horn neurons. The Journal of Physiology. PMID 29352464 DOI: 10.1113/JP275240  0.332
2018 Ratté S, Karnup S, Prescott SA. Nonlinear relationship between spike-dependent calcium influx and TRPC channel activation enables robust persistent spiking in neurons of the anterior cingulate cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29335357 DOI: 10.1523/JNEUROSCI.0538-17.2018  0.708
2018 Mappleback J, Lorenzo L, Lee K, De Koninck Y, Prescott S, Salter M. Disinhibition of spinal cord pain pathways underlies neuropathic pain hypersensitivity in rodents of both sexes The Journal of Pain. 19: S99. DOI: 10.1016/J.Jpain.2017.12.221  0.681
2017 Lesperance LS, Lankarany M, Zhang TC, Esteller R, Ratté S, Prescott SA. Artifactual hyperpolarization during extracellular electrical stimulation: Proposed mechanism of high-rate neuromodulation disproved. Brain Stimulation. PMID 29289565 DOI: 10.1016/J.Brs.2017.12.004  0.804
2016 Takkala P, Zhu Y, Prescott SA. Combined Changes in Chloride Regulation and Neuronal Excitability Enable Primary Afferent Depolarization to Elicit Spiking without Compromising its Inhibitory Effects. Plos Computational Biology. 12: e1005215. PMID 27835641 DOI: 10.1371/Journal.Pcbi.1005215  0.809
2016 Doyon N, Vinay L, Prescott SA, De Koninck Y. Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition. Neuron. 89: 1157-72. PMID 26985723 DOI: 10.1016/J.Neuron.2016.02.030  0.588
2015 Doyon N, Prescott SA, De Koninck Y. Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding. Frontiers in Cellular Neuroscience. 9: 516. PMID 26858607 DOI: 10.3389/fncel.2015.00516  0.573
2015 Coggan JS, Bittner S, Stiefel KM, Meuth SG, Prescott SA. Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling. International Journal of Molecular Sciences. 16: 21215-36. PMID 26370960 DOI: 10.3390/Ijms160921215  0.681
2015 Ratté S, Prescott SA. Afferent hyperexcitability in neuropathic pain and the inconvenient truth about its degeneracy. Current Opinion in Neurobiology. 36: 31-37. PMID 26363576 DOI: 10.1016/j.conb.2015.08.007  0.711
2015 Khubieh A, Ratté S, Lankarany M, Prescott SA. Regulation of Cortical Dynamic Range by Background Synaptic Noise and Feedforward Inhibition. Cerebral Cortex (New York, N.Y. : 1991). PMID 26209846 DOI: 10.1093/Cercor/Bhv157  0.807
2015 Lee KY, Prescott SA. Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade. Pain. PMID 26186265 DOI: 10.1097/j.pain.0000000000000301  0.506
2015 Coggan JS, Sejnowski TJ, Prescott SA. Cooperativity between remote sites of ectopic spiking allows afterdischarge to be initiated and maintained at different locations. Journal of Computational Neuroscience. 39: 17-28. PMID 25929191 DOI: 10.1007/S10827-015-0562-8  0.524
2015 Prescott SA. Synaptic inhibition and disinhibition in the spinal dorsal horn. Progress in Molecular Biology and Translational Science. 131: 359-83. PMID 25744679 DOI: 10.1016/bs.pmbts.2014.11.008  0.326
2015 Price TJ, Prescott SA. Inhibitory regulation of the pain gate and how its failure causes pathological pain. Pain. 156: 789-92. PMID 25719614 DOI: 10.1097/j.pain.0000000000000139  0.497
2015 Zhu Y, Feng B, Schwartz ES, Gebhart GF, Prescott SA. Novel method to assess axonal excitability using channelrhodopsin-based photoactivation. Journal of Neurophysiology. 113: 2242-9. PMID 25609112 DOI: 10.1152/Jn.00982.2014  0.402
2015 Lankarany M, Prescott SA. Multiplexed coding through synchronous and asynchronous spiking Bmc Neuroscience. 16. DOI: 10.1186/1471-2202-16-S1-P198  0.766
2014 Ratté S, Lankarany M, Rho YA, Patterson A, Prescott SA. Subthreshold membrane currents confer distinct tuning properties that enable neurons to encode the integral or derivative of their input. Frontiers in Cellular Neuroscience. 8: 452. PMID 25620913 DOI: 10.3389/Fncel.2014.00452  0.824
2014 Ratté S, Zhu Y, Lee KY, Prescott SA. Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain. Elife. 3: e02370. PMID 24692450 DOI: 10.7554/eLife.02370  0.693
2014 Prescott SA, Ma Q, De Koninck Y. Normal and abnormal coding of somatosensory stimuli causing pain. Nature Neuroscience. 17: 183-91. PMID 24473266 DOI: 10.1038/Nn.3629  0.629
2014 Ratté S, Zhu Y, Lee KY, Prescott SA. Author response: Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain Elife. DOI: 10.7554/Elife.02370.010  0.358
2013 Ratté S, Hong S, De Schutter E, Prescott SA. Impact of neuronal properties on network coding: roles of spike initiation dynamics and robust synchrony transfer. Neuron. 78: 758-72. PMID 23764282 DOI: 10.1016/j.neuron.2013.05.030  0.633
2012 Rho YA, Prescott SA. Identification of molecular pathologies sufficient to cause neuropathic excitability in primary somatosensory afferents using dynamical systems theory. Plos Computational Biology. 8: e1002524. PMID 22654655 DOI: 10.1371/Journal.Pcbi.1002524  0.448
2012 Prescott SA, Ratté S. Pain processing by spinal microcircuits: afferent combinatorics. Current Opinion in Neurobiology. 22: 631-9. PMID 22409855 DOI: 10.1016/j.conb.2012.02.010  0.442
2012 Hong S, Ratté S, Prescott SA, De Schutter E. Single neuron firing properties impact correlation-based population coding. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1413-28. PMID 22279226 DOI: 10.1523/JNEUROSCI.3735-11.2012  0.656
2011 Coggan JS, Ocker GK, Sejnowski TJ, Prescott SA. Explaining pathological changes in axonal excitability through dynamical analysis of conductance-based models. Journal of Neural Engineering. 8: 065002. PMID 22058273 DOI: 10.1088/1741-2560/8/6/065002  0.597
2011 Ratté S, Prescott SA. ClC-2 channels regulate neuronal excitability, not intracellular chloride levels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15838-43. PMID 22049427 DOI: 10.1523/JNEUROSCI.2748-11.2011  0.404
2011 Doyon N, Prescott SA, Castonguay A, Godin AG, Kröger H, De Koninck Y. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. Plos Computational Biology. 7: e1002149. PMID 21931544 DOI: 10.1371/journal.pcbi.1002149  0.602
2011 Coggan JS, Ocker GK, Prescott SA, Sejnowski TJ. Complex symptoms of demyelination and nerve damage explained by nonlinear dynamical analysis of conductance-based models Bmc Neuroscience. 12. DOI: 10.1186/1471-2202-12-S1-P292  0.579
2010 Coggan JS, Prescott SA, Bartol TM, Sejnowski TJ. Imbalance of ionic conductances contributes to diverse symptoms of demyelination. Proceedings of the National Academy of Sciences of the United States of America. 107: 20602-9. PMID 20974975 DOI: 10.1073/Pnas.1013798107  0.512
2010 Doyon N, Prescott S, De Koninck Y. Plasticity of Chloride Homeostasis can Cause Bistability and a Switch in Neuronal Spiking Pattern Biophysical Journal. 98: 139a. DOI: 10.1016/J.BPJ.2009.12.750  0.486
2009 Price TJ, Cervero F, Gold MS, Hammond DL, Prescott SA. Chloride regulation in the pain pathway. Brain Research Reviews. 60: 149-70. PMID 19167425 DOI: 10.1016/J.Brainresrev.2008.12.015  0.404
2008 Prescott SA, Sejnowski TJ. Spike-rate coding and spike-time coding are affected oppositely by different adaptation mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13649-61. PMID 19074038 DOI: 10.1523/JNEUROSCI.1792-08.2008  0.558
2008 Prescott SA, De Koninck Y, Sejnowski TJ. Biophysical basis for three distinct dynamical mechanisms of action potential initiation. Plos Computational Biology. 4: e1000198. PMID 18846205 DOI: 10.1371/journal.pcbi.1000198  0.729
2008 Prescott SA, Ratté S, De Koninck Y, Sejnowski TJ. Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions. Journal of Neurophysiology. 100: 3030-42. PMID 18829848 DOI: 10.1152/jn.90634.2008  0.746
2006 Prescott SA, Sejnowski TJ, De Koninck Y. Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: towards a biophysical basis for neuropathic pain. Molecular Pain. 2: 32. PMID 17040565 DOI: 10.1186/1744-8069-2-32  0.771
2006 Prescott SA, Ratté S, De Koninck Y, Sejnowski TJ. Nonlinear interaction between shunting and adaptation controls a switch between integration and coincidence detection in pyramidal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9084-97. PMID 16957065 DOI: 10.1523/JNEUROSCI.1388-06.2006  0.735
2005 Prescott SA, De Koninck Y. Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4743-54. PMID 15888650 DOI: 10.1523/JNEUROSCI.0356-05.2005  0.686
2003 Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sík A, De Koninck P, De Koninck Y. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature. 424: 938-42. PMID 12931188 DOI: 10.1038/Nature01868  0.806
2003 Prescott SA, De Koninck Y. Gain control of firing rate by shunting inhibition: roles of synaptic noise and dendritic saturation. Proceedings of the National Academy of Sciences of the United States of America. 100: 2076-81. PMID 12569169 DOI: 10.1073/pnas.0337591100  0.645
2002 Prescott SA, De Koninck Y. Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat. The Journal of Physiology. 539: 817-36. PMID 11897852 DOI: 10.1113/jphysiol.2001.013437  0.668
1999 Prescott SA, Chase R. Sites of plasticity in the neural circuit mediating tentacle withdrawal in the snail Helix aspersa: implications for behavioral change and learning kinetics. Learning & Memory (Cold Spring Harbor, N.Y.). 6: 363-80. PMID 10509707 DOI: 10.1101/Lm.6.4.363  0.513
1997 Prescott SA, Gill N, Chase R. Neural circuit mediating tentacle withdrawal in Helix aspersa, with specific reference to the competence of the motor neuron C3. Journal of Neurophysiology. 78: 2951-65. PMID 9405515 DOI: 10.1152/Jn.1997.78.6.2951  0.588
1996 Prescott S, Chase R. Two types of plasticity in the tentacle withdrawal reflex of Helix aspersa are dissociated by tissue location and response measure Journal of Comparative Physiology - a Sensory, Neural, and Behavioral Physiology. 179: 407-414. DOI: 10.1007/Bf00194994  0.447
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