| Year |
Citation |
Score |
| 2021 |
Kocsis I, Ding Y, Williams NH, Hunter CA. Transmembrane signal transduction by cofactor transport. Chemical Science. 12: 12377-12382. PMID 34603667 DOI: 10.1039/d1sc03910e |
0.444 |
|
| 2020 |
Szeler K, Williams NH, Hengge AC, Kamerlin SCL. Modeling the Alkaline Hydrolysis of Diaryl Sulfate Diesters: A Mechanistic Study. The Journal of Organic Chemistry. PMID 32309943 DOI: 10.1021/Acs.Joc.0C00441 |
0.371 |
|
| 2019 |
Taylor C, Metherell A, Argent S, Ashour F, Williams N, Ward M. Coordination cage catalysed hydrolysis of organophosphates: cavity or surface based? Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31774202 DOI: 10.1002/Chem.201904708 |
0.341 |
|
| 2019 |
Ding Y, Williams NH, Hunter CA. A Synthetic Vesicle-to-Vesicle Communication System. Journal of the American Chemical Society. PMID 31642667 DOI: 10.1021/Jacs.9B09102 |
0.462 |
|
| 2018 |
Ward MD, Hunter CA, Williams NH. Coordination Cages Based on Bis(pyrazolylpyridine) Ligands: Structures, Dynamic Behavior, Guest Binding, and Catalysis. Accounts of Chemical Research. PMID 30085644 DOI: 10.1021/Acs.Accounts.8B00261 |
0.515 |
|
| 2018 |
Barrozo A, Liao Q, Esguerra M, Marloie G, Florián J, Williams NH, Kamerlin SCL. Computer simulations of the catalytic mechanism of wild-type and mutant β-phosphoglucomutase. Organic & Biomolecular Chemistry. PMID 29508879 DOI: 10.1039/C8Ob00312B |
0.313 |
|
| 2018 |
Cullen W, Metherell A, Wragg AB, Taylor C, Williams NH, Ward MD. Catalysis in a cationic coordination cage using a cavity-bound guest and surface-bound anions: inhibition, activation and autocatalysis. Journal of the American Chemical Society. PMID 29412665 DOI: 10.1021/Jacs.7B11334 |
0.352 |
|
| 2017 |
Langton MJ, Scriven LM, Williams NH, Hunter CA. Triggered Release from Lipid Bilayer Vesicles by an Artificial Transmembrane Signal Transduction System. Journal of the American Chemical Society. PMID 28876061 DOI: 10.1021/Jacs.7B07747 |
0.437 |
|
| 2017 |
Pabis A, Williams NH, Kamerlin SCL. Simulating the reactions of substituted pyridinio-N-phosphonates with pyridine as a model for biological phosphoryl transfer. Organic & Biomolecular Chemistry. PMID 28819656 DOI: 10.1039/C7Ob01734K |
0.351 |
|
| 2017 |
Chu Y, Williams NH, Hengge AC. Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1. Biochemistry. PMID 28678475 DOI: 10.1021/Acs.Biochem.7B00441 |
0.362 |
|
| 2017 |
Langton MJ, Williams NH, Hunter CA. Recognition-Controlled Membrane Translocation for Signal Transduction across Lipid Bilayers. Journal of the American Chemical Society. PMID 28462993 DOI: 10.1021/Jacs.7B02345 |
0.471 |
|
| 2017 |
Langton MJ, Keymeulen F, Ciaccia M, Williams NH, Hunter CA. Controlled membrane translocation provides a mechanism for signal transduction and amplification. Nature Chemistry. 9: 426-430. PMID 28430205 DOI: 10.1038/Nchem.2678 |
0.436 |
|
| 2017 |
Barrozo A, Blaha-Nelson D, Williams NH, Kamerlin SCL. The effect of magnesium ions on triphosphate hydrolysis Pure and Applied Chemistry. 89: 715-727. DOI: 10.1515/Pac-2016-1125 |
0.379 |
|
| 2017 |
Blackburn GM, Cherfils J, Moss GP, Richards NGJ, Waltho JP, Williams NH, Wittinghofer A. How to name atoms in phosphates, polyphosphates, their derivatives and mimics, and transition state analogues for enzyme-catalysed phosphoryl transfer reactions (IUPAC Recommendations 2016) Pure and Applied Chemistry. 89: 653-675. DOI: 10.1515/Pac-2016-0202 |
0.366 |
|
| 2017 |
Ward MD, Hunter CA, Williams NH. Guest Binding and Catalysis in the Cavity of a Cubic Coordination Cage Chemistry Letters. 46: 2-9. DOI: 10.1246/Cl.160834 |
0.482 |
|
| 2016 |
Duarte F, Barrozo A, Aqvist J, Williams NH, Kamerlin SC. The Competing Mechanisms of Phosphate Monoester Dianion Hydrolysis. Journal of the American Chemical Society. PMID 27471914 DOI: 10.1021/Jacs.6B06277 |
0.409 |
|
| 2016 |
Cullen W, Misuraca MC, Hunter CA, Williams NH, Ward MD. Highly efficient catalysis of the Kemp elimination in the cavity of a cubic coordination cage. Nature Chemistry. 8: 231-6. PMID 26892554 DOI: 10.1038/Nchem.2452 |
0.507 |
|
| 2016 |
Li D, Williams NH. The solvolysis mechanism of simple secondary tosylates in 50% aqueous TFE Journal of Physical Organic Chemistry. 29: 709-717. DOI: 10.1002/Poc.3559 |
0.316 |
|
| 2015 |
Tirel EY, Williams NH. Enhancing Phosphate Diester Cleavage by a Zinc Complex through Controlling Nucleophile Coordination. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 7053-6. PMID 25787696 DOI: 10.1002/Chem.201500619 |
0.381 |
|
| 2015 |
Duarte F, Åqvist J, Williams NH, Kamerlin SC. Resolving apparent conflicts between theoretical and experimental models of phosphate monoester hydrolysis. Journal of the American Chemical Society. 137: 1081-93. PMID 25423607 DOI: 10.1021/Ja5082712 |
0.384 |
|
| 2014 |
Tirel EY, Bellamy Z, Adams H, Lebrun V, Duarte F, Williams NH. Catalytic zinc complexes for phosphate diester hydrolysis. Angewandte Chemie (International Ed. in English). 53: 8246-50. PMID 24919567 DOI: 10.1002/Anie.201400335 |
0.363 |
|
| 2013 |
Kirby AJ, Medeiros M, Mora JR, Oliveira PS, Amer A, Williams NH, Nome F. Intramolecular general base catalysis in the hydrolysis of a phosphate diester. Calculational guidance to a choice of mechanism. The Journal of Organic Chemistry. 78: 1343-53. PMID 23373989 DOI: 10.1021/Jo302498G |
0.558 |
|
| 2013 |
Korhonen H, Williams NH, Mikkola S. βlG values in mechanistic studies on the transesterification of RNA models and their application in a metal ion complex promoted transesterification Journal of Physical Organic Chemistry. 26: 182-186. DOI: 10.1002/Poc.2942 |
0.336 |
|
| 2012 |
Korhonen H, Mikkola S, Williams NH. The mechanism of cleavage and isomerisation of RNA promoted by an efficient dinuclear Zn2+ complex. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 659-70. PMID 22162262 DOI: 10.1002/Chem.201100721 |
0.405 |
|
| 2011 |
Kirby AJ, Medeiros M, Oliveira PS, Orth ES, Brandão TA, Wanderlind EH, Amer A, Williams NH, Nome F. Activating water: important effects of non-leaving groups on the hydrolysis of phosphate triesters. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 14996-5004. PMID 22106028 DOI: 10.1002/Chem.201101926 |
0.564 |
|
| 2011 |
Tomlinson CG, Syson K, Sengerová B, Atack JM, Sayers JR, Swanson L, Tainer JA, Williams NH, Grasby JA. Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions. The Journal of Biological Chemistry. 286: 30878-87. PMID 21734257 DOI: 10.1074/Jbc.M111.230391 |
0.35 |
|
| 2010 |
Sengerová B, Tomlinson C, Atack JM, Williams R, Sayers JR, Williams NH, Grasby JA. Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates. Biochemistry. 49: 8085-93. PMID 20698567 DOI: 10.1021/Bi100895J |
0.356 |
|
| 2010 |
Baxter NJ, Bowler MW, Alizadeh T, Cliff MJ, Hounslow AM, Wu B, Berkowitz DB, Williams NH, Blackburn GM, Waltho JP. Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF-3 rather than by phosphoranes. Proceedings of the National Academy of Sciences of the United States of America. 107: 4555-60. PMID 20164409 DOI: 10.1073/Pnas.0910333106 |
0.363 |
|
| 2010 |
Alkherraz A, Kamerlin SCL, Feng G, Sheikh QI, Warshel A, Williams NH. Phosphate ester analogues as probes for understanding enzyme catalysed phosphoryl transfer Faraday Discussions. 145: 281-299. DOI: 10.1039/B908398G |
0.403 |
|
| 2009 |
Baxter NJ, Hounslow AM, Bowler MW, Williams NH, Blackburn GM, Waltho JP. MgF(3)(-) and alpha-galactose 1-phosphate in the active site of beta-phosphoglucomutase form a transition state analogue of phosphoryl transfer. Journal of the American Chemical Society. 131: 16334-5. PMID 19852484 DOI: 10.1021/Ja905972M |
0.342 |
|
| 2009 |
Feng G, Tanifum EA, Adams H, Hengge AC, Williams NH. Mechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center. Journal of the American Chemical Society. 131: 12771-9. PMID 19673521 DOI: 10.1021/Ja904134N |
0.371 |
|
| 2009 |
Tsang WY, Edwards DR, Melnychuk SA, Liu CT, Liu C, Neverov AA, Williams NH, Brown RS. Dinuclear Zn(II) complex promotes cleavage and isomerization of 2-hydroxypropyl alkyl phosphates by a common cyclic phosphate intermediate. Journal of the American Chemical Society. 131: 4159-66. PMID 19292494 DOI: 10.1021/Ja900525T |
0.328 |
|
| 2009 |
Golicnik M, Olguin LF, Feng G, Baxter NJ, Waltho JP, Williams NH, Hollfelder F. Kinetic analysis of beta-phosphoglucomutase and its inhibition by magnesium fluoride. Journal of the American Chemical Society. 131: 1575-88. PMID 19132841 DOI: 10.1021/Ja806421F |
0.574 |
|
| 2008 |
McWhirter C, Lund EA, Tanifum EA, Feng G, Sheikh QI, Hengge AC, Williams NH. Mechanistic study of protein phosphatase-1 (PP1), a catalytically promiscuous enzyme. Journal of the American Chemical Society. 130: 13673-82. PMID 18798625 DOI: 10.1021/Ja803612Z |
0.388 |
|
| 2008 |
Kamerlin SC, Williams NH, Warshel A. Dineopentyl phosphate hydrolysis: evidence for stepwise water attack. The Journal of Organic Chemistry. 73: 6960-9. PMID 18729515 DOI: 10.1021/Jo801207Q |
0.394 |
|
| 2008 |
Syson K, Tomlinson C, Chapados BR, Sayers JR, Tainer JA, Williams NH, Grasby JA. Three metal ions participate in the reaction catalyzed by T5 flap endonuclease. The Journal of Biological Chemistry. 283: 28741-6. PMID 18697748 DOI: 10.1074/Jbc.M801264200 |
0.339 |
|
| 2008 |
Linjalahti H, Feng G, Mareque-Rivas JC, Mikkola S, Williams NH. Cleavage and isomerization of UpU promoted by dinuclear metal ion complexes. Journal of the American Chemical Society. 130: 4232-3. PMID 18324817 DOI: 10.1135/Css200810404 |
0.373 |
|
| 2008 |
Baxter NJ, Blackburn GM, Marston JP, Hounslow AM, Cliff MJ, Bermel W, Williams NH, Hollfelder F, Wemmer DE, Waltho JP. Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes. Journal of the American Chemical Society. 130: 3952-8. PMID 18318536 DOI: 10.1021/Ja078000N |
0.588 |
|
| 2007 |
Dijkstra HP, Hutchinson JJ, Hunter CA, Qin H, Tomas S, Webb SJ, Williams NH. Transmission of binding information across lipid bilayers. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 7215-22. PMID 17576643 DOI: 10.1002/Chem.200601723 |
0.588 |
|
| 2006 |
Baxter NJ, Olguin LF, Golicnik M, Feng G, Hounslow AM, Bermel W, Blackburn GM, Hollfelder F, Waltho JP, Williams NH. A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site. Proceedings of the National Academy of Sciences of the United States of America. 103: 14732-7. PMID 16990434 DOI: 10.1073/Pnas.0604448103 |
0.59 |
|
| 2006 |
Feng G, Mareque-Rivas JC, Williams NH. Comparing a mononuclear Zn(II) complex with hydrogen bond donors with a dinuclear Zn(II) complex for catalysing phosphate ester cleavage. Chemical Communications (Cambridge, England). 1845-7. PMID 16622503 DOI: 10.1039/B514328D |
0.31 |
|
| 2006 |
Schroeder GK, Lad C, Wyman P, Williams NH, Wolfenden R. The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA. Proceedings of the National Academy of Sciences of the United States of America. 103: 4052-5. PMID 16537483 DOI: 10.1073/Pnas.0510879103 |
0.308 |
|
| 2006 |
Briseño-Roa L, Hill J, Notman S, Sellers D, Smith AP, Timperley CM, Wetherell J, Williams NH, Williams GR, Fersht AR, Griffiths AD. Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents. Journal of Medicinal Chemistry. 49: 246-55. PMID 16392809 DOI: 10.1021/Jm050518J |
0.366 |
|
| 2005 |
Feng G, Mareque-Rivas JC, Torres Martín de Rosales R, Williams NH. A highly reactive mononuclear Zn(II) complex for phosphodiester cleavage. Journal of the American Chemical Society. 127: 13470-1. PMID 16190690 DOI: 10.1021/Ja054003T |
0.364 |
|
| 2004 |
Humphry T, Forconi M, Williams NH, Hengge AC. Altered mechanisms of reactions of phosphate esters bridging a dinuclear metal center. Journal of the American Chemical Society. 126: 11864-9. PMID 15382921 DOI: 10.1021/Ja047110G |
0.725 |
|
| 2004 |
Williams NH. Models for biological phosphoryl transfer. Biochimica Et Biophysica Acta. 1697: 279-87. PMID 15023368 DOI: 10.1016/J.Bbapap.2003.11.031 |
0.44 |
|
| 2004 |
Padovani M, Williams NH, Wyman P. Mononuclear Co(III)-complex promoted phosphate diester hydrolysis: Dependence of reactivity on the leaving group Journal of Physical Organic Chemistry. 17: 472-477. DOI: 10.1002/Poc.770 |
0.393 |
|
| 2003 |
Blackburn GM, Williams NH, Gamblin SJ, Smerdon SJ. Comment on "The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction". Science (New York, N.Y.). 301: 1184; author reply 1. PMID 12947182 DOI: 10.1126/Science.1085796 |
0.311 |
|
| 2003 |
Aström H, Williams NH, Strömberg R. Oligonucleotide based artificial nuclease (OBAN) systems. Bulge size dependence and positioning of catalytic group in cleavage of RNA-bulges. Organic & Biomolecular Chemistry. 1: 1461-5. PMID 12926273 DOI: 10.1039/B212216B |
0.309 |
|
| 2003 |
Lad C, Williams NH, Wolfenden R. The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases. Proceedings of the National Academy of Sciences of the United States of America. 100: 5607-10. PMID 12721374 DOI: 10.1073/Pnas.0631607100 |
0.39 |
|
| 2003 |
Doyle EL, Hunter CA, Phillips HC, Webb SJ, Williams NH. Cooperative binding at lipid bilayer membrane surfaces. Journal of the American Chemical Society. 125: 4593-9. PMID 12683831 DOI: 10.1021/Ja021048A |
0.59 |
|
| 2002 |
Forconi M, Williams NH. Mimicking metallophosphatases: revealing a role for an OH group with no libido. Angewandte Chemie (International Ed. in English). 41: 849-52. PMID 12491357 DOI: 10.1002/1521-3757(20020301)114:5<877::Aid-Ange877>3.0.Co;2-K |
0.684 |
|
| 2002 |
Humphry T, Forconi M, Williams NH, Hengge AC. An altered mechanism of hydrolysis for a metal-complexed phosphate diester. Journal of the American Chemical Society. 124: 14860-1. PMID 12475323 DOI: 10.1021/Ja027671C |
0.729 |
|
| 2002 |
Barton P, Hunter CA, Potter TJ, Webb SJ, Williams NH. Transmembrane signalling. Angewandte Chemie (International Ed. in English). 41: 3878-81. PMID 12386877 DOI: 10.1002/1521-3773(20021018)41:20<3878::AID-ANIE3878>3.0.CO;2-F |
0.508 |
|
| 2001 |
Williams NH, Wyman P. Phosphate diester hydrolysis within a highly reactive dinuclear cobalt(III) complex. Ligand effect on reactivity, transition state and dissociation Journal of the Chemical Society, Perkin Transactions 2. 2068-2073. DOI: 10.1039/B106374J |
0.401 |
|
| 1999 |
Williams NH, Lebuis AM, Chin J. A structural and functional model of dinuclear metallophosphatases Journal of the American Chemical Society. 121: 3341-3348. DOI: 10.1021/Ja9827797 |
0.314 |
|
| 1999 |
Williams NH, Takasaki B, Wall M, Chin J. Structure and nuclease activity of simple dinuclear metal complexes: Quantitative dissection of the role of metal ions Accounts of Chemical Research. 32: 485-493. DOI: 10.1021/Ar9500877 |
0.302 |
|
| 1998 |
Williams NH, Cheung W, Chin J. Reactivity of phosphate diesters doubly coordinated to a dinuclear Cobalt(III) complex: Dependence of the reactivity on the basicity of the leaving group Journal of the American Chemical Society. 120: 8079-8087. DOI: 10.1021/Ja980660S |
0.335 |
|
| 1996 |
Williams NH, Chin J. Metal-ion catalysed phosphate diester transesterification: Quantifying double Lewis-acid activation Chemical Communications. 131-132. DOI: 10.1039/Cc9960000131 |
0.309 |
|
| 1994 |
Kirby AJ, Williams NH. Efficient intramolecular general acid catalysis of enol ether hydrolysis. Hydrogen-bonding stabilisation of the transition state for proton transfer to carbon Journal of the Chemical Society, Perkin Transactions 2. 643-648. DOI: 10.1039/P29940000643 |
0.535 |
|
| 1992 |
Kirby AJ, Williams NH. The anomeric effects of aryloxy groups Journal of the Chemical Society, Chemical Communications. 1286-1287. DOI: 10.1039/C39920001286 |
0.49 |
|
| 1992 |
Kirby AJ, Williams NH. Electronic effects on conformational preferences: A-values for aryloxy groups Journal of the Chemical Society, Chemical Communications. 1285-1286. DOI: 10.1039/C39920001285 |
0.484 |
|
| 1991 |
Kirby AJ, Williams NH. There is no evidence for electrostatic catalysis of vinyl ether hydrolysis in water Journal of the Chemical Society, Chemical Communications. 1644-1645. DOI: 10.1039/C39910001644 |
0.535 |
|
| 1991 |
Kirby AJ, Williams NH. Efficient intramolecular general acid catalysis of vinyl ether hydrolysis by the neighbouring carboxylic acid group Journal of the Chemical Society, Chemical Communications. 1643-1644. DOI: 10.1039/C39910001643 |
0.521 |
|
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