Year |
Citation |
Score |
2024 |
Prajapati K, Yan C, Yang Q, Arbitman S, Fitzgerald DP, Sharee S, Shaik J, Bosiacki J, Myers K, Paucarmayta A, Johnson DM, O'Neill T, Kundu S, Cusumano Z, Langermann S, ... ... Flies DB, et al. The FLRT3-UNC5B checkpoint pathway inhibits T cell-based cancer immunotherapies. Science Advances. 10: eadj4698. PMID 38427724 DOI: 10.1126/sciadv.adj4698 |
0.382 |
|
2023 |
Wang Q, He J, Flies DB, Luo L, Chen L. Author Correction: Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Scientific Reports. 13: 11603. PMID 37463928 DOI: 10.1038/s41598-023-37791-w |
0.431 |
|
2021 |
Vijver SV, Singh A, Mommers-Elshof ETAM, Meeldijk J, Copeland R, Boon L, Langermann S, Flies D, Meyaard L, Ramos MIP. Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1. Frontiers in Immunology. 12: 733561. PMID 34691040 DOI: 10.3389/fimmu.2021.733561 |
0.314 |
|
2021 |
Ramos MIP, Tian L, de Ruiter EJ, Song C, Paucarmayta A, Singh A, Elshof E, Vijver SV, Shaik J, Bosiacki J, Cusumano Z, Jensen C, Willumsen N, Karsdal MA, Liu L, ... ... Flies D, et al. Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction. Elife. 10. PMID 34121658 DOI: 10.7554/eLife.62927 |
0.351 |
|
2019 |
Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, et al. PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus. Science Translational Medicine. 11. PMID 31826980 DOI: 10.1126/Scitranslmed.Aax1159 |
0.508 |
|
2019 |
Wang J, Sun J, Liu LN, Flies DB, Nie X, Toki M, Zhang J, Song C, Zarr M, Zhou X, Han X, Archer KA, O'Neill T, Herbst RS, Boto AN, et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature Medicine. PMID 30833750 DOI: 10.1038/S41591-019-0374-X |
0.603 |
|
2017 |
Wang Q, He J, Flies DB, Luo L, Chen L. Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Scientific Reports. 7: 6086. PMID 28729608 DOI: 10.1038/S41598-017-06410-W |
0.568 |
|
2016 |
Flies DB, Higuchi T, Harris JC, Jha V, Gimotty PA, Adams SF. Immune checkpoint blockade reveals the stimulatory capacity of tumor-associated CD103(+) dendritic cells in late-stage ovarian cancer. Oncoimmunology. 5: e1185583. PMID 27622059 DOI: 10.1080/2162402X.2016.1185583 |
0.405 |
|
2015 |
Higuchi T, Flies DB, Marjon NA, Mantia-Smaldone G, Ronner L, Gimotty PA, Adams SF. CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer. Cancer Immunology Research. 3: 1257-68. PMID 26138335 DOI: 10.1158/2326-6066.Cir-15-0044 |
0.308 |
|
2015 |
Flies DB, Higuchi T, Chen L. Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens. Journal of Immunology (Baltimore, Md. : 1950). 194: 5294-304. PMID 25917101 DOI: 10.4049/Jimmunol.1402648 |
0.577 |
|
2014 |
Flies DB, Han X, Higuchi T, Zheng L, Sun J, Ye JJ, Chen L. Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity. The Journal of Clinical Investigation. 124: 1966-75. PMID 24743150 DOI: 10.1172/Jci74589 |
0.606 |
|
2013 |
Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nature Reviews. Immunology. 13: 227-42. PMID 23470321 DOI: 10.1038/Nri3405 |
0.509 |
|
2013 |
Chen L, Flies DB. Erratum: Molecular mechanisms of T cell co-stimulation and co-inhibition Nature Reviews Immunology. 13: 542-542. DOI: 10.1038/Nri3484 |
0.546 |
|
2011 |
Flies DB, Sandler BJ, Sznol M, Chen L. Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy. The Yale Journal of Biology and Medicine. 84: 409-21. PMID 22180678 |
0.522 |
|
2011 |
Flies DB, Wang S, Xu H, Chen L. Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models. Journal of Immunology (Baltimore, Md. : 1950). 187: 1537-41. PMID 21768399 DOI: 10.4049/Jimmunol.1100660 |
0.544 |
|
2011 |
Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L. B7-h2 is a costimulatory ligand for CD28 in human. Immunity. 34: 729-40. PMID 21530327 DOI: 10.1016/J.Immuni.2011.03.014 |
0.739 |
|
2010 |
Nguyen LT, Ciric B, Van Keulen VP, Rodriguez M, Pease LR, Tamada K, Flies DB, Chen L. Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Research. 70: 9528. PMID 21045150 DOI: 10.1158/0008-5472.Can-10-3461 |
0.471 |
|
2007 |
Flies DB, Chen L. The new B7s: playing a pivotal role in tumor immunity. Journal of Immunotherapy (Hagerstown, Md. : 1997). 30: 251-60. PMID 17414316 DOI: 10.1097/Cji.0B013E31802E085A |
0.54 |
|
2007 |
Xu Y, Flies AS, Flies DB, Zhu G, Anand S, Flies SJ, Xu H, Anders RA, Hancock WW, Chen L, Tamada K. Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood. 109: 4097-104. PMID 17179227 DOI: 10.1182/Blood-2006-09-047332 |
0.701 |
|
2006 |
Flies DB, Chen L. Modulation of immune response by B7 family molecules in tumor microenvironments. Immunological Investigations. 35: 395-418. PMID 16916759 DOI: 10.1080/08820130600755017 |
0.479 |
|
2006 |
Anand S, Wang P, Yoshimura K, Choi IH, Hilliard A, Chen YH, Wang CR, Schulick R, Flies AS, Flies DB, Zhu G, Xu Y, Pardoll DM, Chen L, Tamada K. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. The Journal of Clinical Investigation. 116: 1045-51. PMID 16557300 DOI: 10.1172/Jci27083 |
0.679 |
|
2006 |
Drake CG, Kelleher C, Bruno T, Harris T, Flies D, Getnet D, Hipkiss E, Maris C, Grosso J. Blocking the regulatory T cell molecule LAG-3 augments in vivo anti-tumor immunity in an autochthonous model of prostate cancer Journal of Clinical Oncology. 24: 2573-2573. DOI: 10.1200/Jco.2006.24.18_Suppl.2573 |
0.552 |
|
2005 |
Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, Rietz C, Flies DB, Lau JS, Zhu G, Tamada K, Chen L. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Research. 65: 1089-96. PMID 15705911 |
0.598 |
|
2005 |
Aalamian-Mattheis M, Wang J, Jalla S, Hipkiss E, Flies D, Harris T, Drake CG, Pardoll DM, Fuchs EJ. 245: Regression of Prostate Cancer in Animals Treated with Donor Lymphocyte Infusion (DLI) and a Cell Based Tumor Vaccine after Conditioning with a Single Dose of Cyclophosphamide Journal of Urology. 173: 67-67. DOI: 10.1016/S0022-5347(18)34510-5 |
0.304 |
|
2004 |
Luo L, Chapoval AI, Flies DB, Zhu G, Hirano F, Wang S, Lau JS, Dong H, Tamada K, Flies AS, Liu Y, Chen L. B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 5445-50. PMID 15494491 DOI: 10.4049/Jimmunol.173.9.5445 |
0.645 |
|
2004 |
Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Levitsky HI, Powell JD, Pardoll DM, Drake CG, Vignali DA. Role of LAG-3 in regulatory T cells. Immunity. 21: 503-13. PMID 15485628 DOI: 10.1016/J.Immuni.2004.08.010 |
0.533 |
|
2004 |
Radhakrishnan S, Nguyen LT, Ciric B, Flies D, Van Keulen VP, Tamada K, Chen L, Rodriguez M, Pease LR. Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Research. 64: 4965-72. PMID 15256470 DOI: 10.1158/0008-5472.Can-03-3025 |
0.618 |
|
2004 |
Dong H, Zhu G, Tamada K, Flies DB, van Deursen JM, Chen L. B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity. 20: 327-36. PMID 15030776 DOI: 10.1016/S1074-7613(04)00050-0 |
0.59 |
|
2004 |
Wilcox RA, Tamada K, Flies DB, Zhu G, Chapoval AI, Blazar BR, Kast WM, Chen L. Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo. Blood. 103: 177-84. PMID 12969968 DOI: 10.1182/Blood-2003-06-2184 |
0.611 |
|
2003 |
Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L. Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. Journal of Immunology (Baltimore, Md. : 1950). 171: 4650-4. PMID 14568939 DOI: 10.4049/Jimmunol.171.9.4650 |
0.539 |
|
2003 |
Strome SE, Dong H, Tamura H, Voss SG, Flies DB, Tamada K, Salomao D, Cheville J, Hirano F, Lin W, Kasperbauer JL, Ballman KV, Chen L. B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Research. 63: 6501-5. PMID 14559843 |
0.597 |
|
2003 |
Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity. 18: 849-61. PMID 12818165 DOI: 10.1016/S1074-7613(03)00152-3 |
0.618 |
|
2003 |
Flies DB, Chen L. A simple and rapid vortex method for preparing antigen/adjuvant emulsions for immunization. Journal of Immunological Methods. 276: 239-42. PMID 12738377 DOI: 10.1016/S0022-1759(03)00081-4 |
0.413 |
|
2003 |
Wang S, Bajorath J, Flies DB, Dong H, Honjo T, Chen L. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. The Journal of Experimental Medicine. 197: 1083-91. PMID 12719480 DOI: 10.1084/Jem.20021752 |
0.517 |
|
2003 |
Dong H, Strome SE, Matteson EL, Moder KG, Flies DB, Zhu G, Tamura H, Driscoll CLW, Chen L. Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis Journal of Clinical Investigation. 111: 363-370. PMID 12569162 DOI: 10.1172/Jci16015 |
0.62 |
|
2002 |
Wilcox RA, Flies DB, Wang H, Tamada K, Johnson AJ, Pease LR, Rodriguez M, Guo Y, Chen L. Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy. Cancer Research. 62: 4413-8. PMID 12154048 |
0.534 |
|
2002 |
Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nature Medicine. 8: 793-800. PMID 12091876 DOI: 10.1038/Nm730 |
0.634 |
|
2002 |
Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB, Tamada K, Mittler RS, Tsuchiya H, Pardoll DM, Chen L. Cutting edge: Expression of functional CD137 receptor by dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 168: 4262-7. PMID 11970964 DOI: 10.4049/Jimmunol.168.9.4262 |
0.574 |
|
2002 |
Strome SE, Voss S, Wilcox R, Wakefield TL, Tamada K, Flies D, Chapoval A, Lu J, Kasperbauer JL, Padley D, Vile R, Gastineau D, Wettstein P, Chen L. Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Research. 62: 1884-9. PMID 11912169 |
0.516 |
|
2002 |
Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, Strome SE, Pease LR, Chen L. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. The Journal of Clinical Investigation. 109: 651-9. PMID 11877473 DOI: 10.1172/Jci14184 |
0.528 |
|
2002 |
Strome SE, Martin E, Flies D, Khurana D, Salomao D, Tamada K, Chapoval AI, Kasperbauer JL, Olsen KD, Chen L. Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 126: 180-7. PMID 11870350 DOI: 10.1067/Mhn.2002.122263 |
0.557 |
|
2002 |
Tamada K, Tamura H, Flies D, Fu YX, Celis E, Pease LR, Blazar BR, Chen L. Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. The Journal of Clinical Investigation. 109: 549-57. PMID 11854328 DOI: 10.1172/JCI13604 |
0.616 |
|
2002 |
Tamada K, Tamura H, Flies D, Fu YX, Celis E, Pease LR, Blazar BR, Chen L. Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease Journal of Clinical Investigation. 109: 549-557. DOI: 10.1172/Jci200213604 |
0.651 |
|
2001 |
Zhu G, Flies DB, Tamada K, Sun Y, Rodriguez M, Fu YX, Chen L. Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 167: 2671-6. PMID 11509610 DOI: 10.4049/Jimmunol.167.5.2671 |
0.592 |
|
2001 |
Tamura H, Dong H, Zhu G, Sica GL, Flies DB, Tamada K, Chen L. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood. 97: 1809-16. PMID 11238124 DOI: 10.1182/Blood.V97.6.1809 |
0.652 |
|
2001 |
Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nature Immunology. 2: 269-74. PMID 11224528 DOI: 10.1038/85339 |
0.651 |
|
2000 |
Strome SE, Martin B, Flies D, Tamada K, Chapoval AI, Sargent DJ, Shu S, Chen L. Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma. Journal of Immunotherapy (Hagerstown, Md. : 1997). 23: 430-7. PMID 10916752 DOI: 10.1097/00002371-200007000-00006 |
0.635 |
|
2000 |
Tamada K, Shimozaki K, Chapoval AI, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu YX, Nagata S, Ni J, Chen L. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nature Medicine. 6: 283-9. PMID 10700230 DOI: 10.1038/73136 |
0.641 |
|
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