| Year |
Citation |
Score |
| 2022 |
Muendlein HI, Connolly WM, Cameron J, Jetton D, Magri Z, Smirnova I, Vannier E, Li X, Martinot AJ, Batorsky R, Poltorak A. Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses. Science Immunology. 7: eadd0665. PMID 36563168 DOI: 10.1126/sciimmunol.add0665 |
0.441 |
|
| 2022 |
Muendlein HI, Connolly WM, Magri Z, Jetton D, Smirnova I, Degterev A, Balachandran S, Poltorak A. ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF. Proceedings of the National Academy of Sciences of the United States of America. 119: e2113872119. PMID 35666872 DOI: 10.1073/pnas.2113872119 |
0.482 |
|
| 2021 |
Muendlein HI, Connolly WM, Magri Z, Smirnova I, Ilyukha V, Gautam A, Degterev A, Poltorak A. ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1. Nature Communications. 12: 86. PMID 33397971 DOI: 10.1038/s41467-020-20357-z |
0.335 |
|
| 2020 |
Muendlein HI, Poltorak A. Flipping the Switch from Inflammation to Cell Death. Trends in Immunology. 41: 648-651. PMID 32622855 DOI: 10.1016/J.It.2020.06.007 |
0.384 |
|
| 2020 |
Muendlein HI, Jetton D, Connolly WM, Eidell KP, Magri Z, Smirnova I, Poltorak A. cFLIP protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation. Science (New York, N.Y.). 367: 1379-1384. PMID 32193329 DOI: 10.1126/Science.Aay3878 |
0.44 |
|
| 2020 |
Muendlein HI, Sarhan J, Liu BC, Connolly WM, Schworer SA, Smirnova I, Tang AY, Ilyukha V, Pietruska J, Tahmasebi S, Sonenberg N, Degterev A, Poltorak A. Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation. Cell Reports. 30: 699-713.e4. PMID 31968247 DOI: 10.1016/J.Celrep.2019.12.073 |
0.757 |
|
| 2019 |
Nikitin D, Garazha A, Sorokin M, Penzar D, Tkachev V, Markov A, Gaifullin N, Borger P, Poltorak A, Buzdin A. Retroelement-Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution. Cells. 8. PMID 30736359 DOI: 10.3390/Cells8020130 |
0.355 |
|
| 2018 |
Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY, Rongvaux A, Bunnell SC, Shao F, Green DR, Poltorak A. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 30381458 DOI: 10.1073/Pnas.1809548115 |
0.412 |
|
| 2018 |
Liu BC, Sarhan J, Poltorak A. Host-Intrinsic Interferon Status in Infection and Immunity. Trends in Molecular Medicine. 24: 658-668. PMID 30060835 DOI: 10.1016/J.Molmed.2018.06.004 |
0.444 |
|
| 2018 |
Poltorak A, Apalko S, Sherbak S. Wild-derived mice: from genetic diversity to variation in immune responses. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 30056578 DOI: 10.1007/S00335-018-9766-3 |
0.443 |
|
| 2018 |
Liu BC, Sarhan J, Panda A, Muendlein HI, Ilyukha V, Coers J, Yamamoto M, Isberg RR, Poltorak A. Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses. Cell Reports. 24: 155-168.e5. PMID 29972777 DOI: 10.1016/J.Celrep.2018.06.012 |
0.515 |
|
| 2018 |
Sarhan J, Liu BC, Muendlein HI, Weindel CG, Smirnova I, Tang AY, Ilyukha V, Sorokin M, Buzdin A, Fitzgerald KA, Poltorak A. Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis. Cell Death and Differentiation. PMID 29786074 DOI: 10.1038/S41418-018-0122-7 |
0.516 |
|
| 2018 |
Nikitin D, Penzar D, Garazha A, Sorokin M, Tkachev V, Borisov N, Poltorak A, Prassolov V, Buzdin AA. Profiling of Human Molecular Pathways Affected by Retrotransposons at the Level of Regulation by Transcription Factor Proteins. Frontiers in Immunology. 9: 30. PMID 29441061 DOI: 10.3389/Fimmu.2018.00030 |
0.434 |
|
| 2017 |
Larkin B, Ilyukha V, Sorokin M, Buzdin A, Vannier E, Poltorak A. Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death. Journal of Immunology (Baltimore, Md. : 1950). PMID 28615418 DOI: 10.4049/Jimmunol.1601999 |
0.419 |
|
| 2016 |
Surpris G, Poltorak A. The expanding regulatory network of STING-mediated signaling. Current Opinion in Microbiology. 32: 144-150. PMID 27414485 DOI: 10.1016/J.Mib.2016.05.014 |
0.423 |
|
| 2016 |
Najjar M, Saleh D, Zelic M, Nogusa S, Shah S, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen MJ, Pasparakis M, Balachandran S, Kelliher M, Poltorak A, et al. RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4. Immunity. PMID 27396959 DOI: 10.1016/J.Immuni.2016.06.007 |
0.519 |
|
| 2016 |
Poltorak A, Kurmyshkina O, Volkova T. Stimulator of interferon genes (STING): A "new chapter" in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity. Cytokine & Growth Factor Reviews. 29: 83-91. PMID 26980676 DOI: 10.1016/J.Cytogfr.2016.02.009 |
0.479 |
|
| 2016 |
Ram DR, Ilyukha V, Volkova T, Buzdin A, Tai A, Smirnova I, Poltorak A. Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 113: 1606-11. PMID 26798068 DOI: 10.1073/Pnas.1517562113 |
0.359 |
|
| 2015 |
Surpris G, Chan J, Thompson M, Ilyukha V, Liu BC, Atianand M, Sharma S, Volkova T, Smirnova I, Fitzgerald KA, Poltorak A. Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production. Journal of Immunology (Baltimore, Md. : 1950). PMID 26685207 DOI: 10.4049/Jimmunol.1501415 |
0.435 |
|
| 2015 |
Poltorak A, Kurmyshkina OV, Larkin B, Surpris G, Ilyukha VV, Volkova TO. ID: 73 Cytokine. 76: 78-79. DOI: 10.1016/J.Cyto.2015.08.103 |
0.395 |
|
| 2014 |
Schworer SA, Smirnova II, Kurbatova I, Bagina U, Churova M, Fowler T, Roy AL, Degterev A, Poltorak A. Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice. The Journal of Biological Chemistry. 289: 14422-33. PMID 24706750 DOI: 10.1074/Jbc.M114.547547 |
0.792 |
|
| 2013 |
Moseman AP, Moseman EA, Schworer S, Smirnova I, Volkova T, von Andrian U, Poltorak A. Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides. Journal of Immunology (Baltimore, Md. : 1950). 191: 5615-24. PMID 24184555 DOI: 10.4049/Jimmunol.1301438 |
0.723 |
|
| 2011 |
Smith PM, Jacque B, Conner JR, Poltorak A, Stadecker MJ. IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in Helminthic infection Plos Pathogens. 7. PMID 21998578 DOI: 10.1371/Journal.Ppat.1002272 |
0.715 |
|
| 2010 |
Conner JR, Smirnova II, Moseman AP, Poltorak A. IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-κB p50 Proceedings of the National Academy of Sciences of the United States of America. 107: 11477-11482. PMID 20534545 DOI: 10.1073/Pnas.1006894107 |
0.731 |
|
| 2009 |
Smith PM, Shainheit MG, Bazzone LE, Rutitzky LI, Poltorak A, Stadecker MJ. Genetic control of severe egg-induced immunopathology and IL-17 production in murine schistosomiasis. Journal of Immunology (Baltimore, Md. : 1950). 183: 3317-23. PMID 19675160 DOI: 10.4049/Jimmunol.0901504 |
0.403 |
|
| 2009 |
Conner JR, Smirnova II, Poltorak A. A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice Journal of Experimental Medicine. 206: 1615-1631. PMID 19564352 DOI: 10.1084/Jem.20090490 |
0.751 |
|
| 2009 |
Losick VP, Stephan K, Smirnova II, Isberg RR, Poltorak A. A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth. Infection and Immunity. 77: 196-204. PMID 18981241 DOI: 10.1128/Iai.01011-08 |
0.714 |
|
| 2008 |
Conner JR, Smirnova II, Poltorak A. Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1. The Journal of Experimental Medicine. 205: 305-14. PMID 18268037 DOI: 10.1084/Jem.20071499 |
0.777 |
|
| 2007 |
Stephan K, Smirnova I, Jacque B, Poltorak A. Genetic analysis of the innate immune responses in wild-derived inbred strains of mice. European Journal of Immunology. 37: 212-23. PMID 17163447 DOI: 10.1002/Eji.200636156 |
0.78 |
|
| 2006 |
Jacque B, Stephan K, Smirnova I, Kim B, Gilling D, Poltorak A. Mice expressing high levels of soluble CD14 retain LPS in the circulation and are resistant to LPS-induced lethality. European Journal of Immunology. 36: 3007-16. PMID 17039565 DOI: 10.1002/Eji.200636038 |
0.718 |
|
| 2004 |
Ehl S, Bischoff R, Ostler T, Vallbracht S, Schulte-Mönting J, Poltorak A, Freudenberg M. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. European Journal of Immunology. 34: 1146-53. PMID 15048726 DOI: 10.1002/Eji.200324449 |
0.485 |
|
| 2003 |
Kalis C, Kanzler B, Lembo A, Poltorak A, Galanos C, Freudenberg MA. Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice. European Journal of Immunology. 33: 798-805. PMID 12616500 DOI: 10.1002/Eji.200323431 |
0.528 |
|
| 2001 |
Poltorak A, Merlin T, Nielsen PJ, Sandra O, Smirnova I, Schupp I, Boehm T, Galanos C, Freudenberg MA. A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice. Journal of Immunology. 167: 2106-2111. PMID 11489994 DOI: 10.4049/Jimmunol.167.4.2106 |
0.441 |
|
| 2001 |
Beutler B, Poltorak A. Sepsis and evolution of the innate immune response. Critical Care Medicine. 29: S2-6; discussion S6-. PMID 11445725 DOI: 10.1097/00003246-200107001-00002 |
0.463 |
|
| 2001 |
Beutler B, Poltorak A. Toll we meet again.... Nature Immunology. 2: 9-10. PMID 11135568 DOI: 10.1038/83222 |
0.462 |
|
| 2001 |
Beutler B, Du X, Poltorak A. Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies Journal of Endotoxin Research. 7: 277-280. DOI: 10.1179/096805101101532846 |
0.476 |
|
| 2000 |
Smirnova I, Poltorak A, Chan EK, McBride C, Beutler B. Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4). Genome Biology. 1: RESEARCH002. PMID 11104518 DOI: 10.1186/Gb-2000-1-1-Research002 |
0.536 |
|
| 2000 |
Poltorak A, Smirnova I, Clisch R, Beutler B. Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice. Journal of Endotoxin Research. 6: 51-6. PMID 11061032 DOI: 10.1177/09680519000060010701 |
0.533 |
|
| 2000 |
Rehli M, Poltorak A, Schwarzfischer L, Krause SW, Andreesen R, Beutler B. PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. The Journal of Biological Chemistry. 275: 9773-81. PMID 10734131 DOI: 10.1074/Jbc.275.13.9773 |
0.504 |
|
| 2000 |
Poltorak A, Ricciardi-Castagnoli P, Citterio S, Beutler BA. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation Proceedings of the National Academy of Sciences of the United States of America. 97: 2163-2167. PMID 10681462 DOI: 10.1073/Pnas.040565397 |
0.453 |
|
| 2000 |
Du X, Poltorak A, Silva M, Beutler B. Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor. Blood Cells, Molecules & Diseases. 25: 328-38. PMID 10660480 DOI: 10.1006/Bcmd.1999.0262 |
0.496 |
|
| 2000 |
Beutler B, Poltorak A. The search for Lps: 1993–1998 Journal of Endotoxin Research. 6: 269-293. DOI: 10.1179/096805100101532153 |
0.325 |
|
| 2000 |
Beutler B, Poltorak A. The search for Lps Journal of Endotoxin Research. 6: 301-302. DOI: 10.1177/09680519000060040401 |
0.333 |
|
| 2000 |
Beutler B, Poltorak A. Review: The search for Lps: 1993—1998 Journal of Endotoxin Research. 6: 269-293. DOI: 10.1177/09680519000060040201 |
0.322 |
|
| 2000 |
Du X, Poltorak A, Silva M, Beutler B. Analysis of Tlr4-Mediated LPS Signal Transduction in Macrophages by Mutational Modification of the Receptor Blood Cells, Molecules, and Diseases. 26: 9. DOI: 10.1006/Bcmd.2000.0278 |
0.387 |
|
| 1998 |
Poltorak A, Smirnova I, He X, Liu MY, Van Huffel C, McNally O, Birdwell D, Alejos E, Silva M, Du X, Thompson P, Chan EK, Ledesma J, Roe B, Clifton S, et al. Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells, Molecules & Diseases. 24: 340-55. PMID 10087992 DOI: 10.1006/Bcmd.1998.0201 |
0.358 |
|
| 1998 |
Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene Science. 282: 2085-2088. PMID 9851930 DOI: 10.1126/Science.282.5396.2085 |
0.475 |
|
| 1994 |
Poltorak A, Peppel K, Beutler B. Receptor-mediated label-transfer assay (RELAY): a novel method for the detection of plasma tumor necrosis factor at attomolar concentrations. Journal of Immunological Methods. 169: 93-99. PMID 8133076 DOI: 10.1016/0022-1759(94)90128-7 |
0.332 |
|
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