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Jonathan K. Watts, Ph.D. - Publications

Affiliations: 
2012-2015 Chemistry University of Southampton, Southampton, England, United Kingdom 
 2015- RNA Therapeutics Institute UMass Chan Medical School 
Area:
Nucleic Acid Therapeutics, Chemical Biology
Website:
https://www.umassmed.edu/wattslab/
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ferguson CM, Godinho BMDC, Echeverria D, Hassler M, Vangjeli L, Sousa J, McHugh N, Alterman J, Hariharan V, Krishnamurthy PM, Watts J, Rogaev E, Khvorova A. A combinatorial approach for achieving CNS-selective RNAi. Nucleic Acids Research. PMID 38348876 DOI: 10.1093/nar/gkae100  0.32
2023 Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Amrani N, Chen Z, Gaston N, Wagh A, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, ... ... Watts JK, et al. Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo. Nucleic Acids Research. PMID 38033325 DOI: 10.1093/nar/gkad1125  0.359
2023 Shah S, Sharp KJ, Raju Ponny S, Lee J, Watts JK, Berry-Kravis E, Richter JD. Antisense oligonucleotide rescue of CGG expansion-dependent mis-splicing in fragile X syndrome restores FMRP. Proceedings of the National Academy of Sciences of the United States of America. 120: e2302534120. PMID 37364131 DOI: 10.1073/pnas.2302534120  0.366
2023 Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Chen Z, Gaston N, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, et al. Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing . Biorxiv : the Preprint Server For Biology. PMID 36993169 DOI: 10.1101/2023.03.20.533459  0.354
2023 Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, ... ... Watts JK, et al. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219523120. PMID 36893269 DOI: 10.1073/pnas.2219523120  0.64
2022 Wang F, Calvo-Roitberg E, Rembetsy-Brown JM, Fang M, Sousa J, Kartje ZJ, Krishnamurthy PM, Lee J, Green MR, Pai AA, Watts JK. G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic Acids Research. PMID 36511872 DOI: 10.1093/nar/gkac1108  0.411
2021 Goddard LR, Mardle CE, Gneid H, Ball CG, Gowers DM, Atkins HS, Butt LE, Watts JK, Vincent HA, Callaghan AJ. An Investigation into the Potential of Targeting mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy. Molecules (Basel, Switzerland). 26. PMID 34200016 DOI: 10.3390/molecules26113414  0.322
2020 Price DA, Kartje ZJ, Hughes JA, Hill TD, Loth TM, Watts JK, Gagnon KT, Moran SD. Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-quadruplexes. Chembiochem : a European Journal of Chemical Biology. PMID 32372560 DOI: 10.1002/cbic.202000136  0.595
2020 Wang F, Zuroske T, Watts JK. RNA therapeutics on the rise. Nature Reviews. Drug Discovery. PMID 32341501 DOI: 10.1038/d41573-020-00078-0  0.339
2020 Watts JK, Ockene IS. RNA Interference for the Masses? siRNA Targeting PCSK9 Promises Prevention of Cardiovascular Disease. Nucleic Acid Therapeutics. PMID 31928497 DOI: 10.1089/nat.2019.0835  0.309
2018 Debacker AJ, Sharma VK, Meda Krishnamurthy P, O'Reilly D, Greenhill R, Watts J. Next-generation PNA chimeras exhibit high affinity and potent gene silencing. Biochemistry. PMID 30520300 DOI: 10.1021/acs.biochem.8b00827  0.692
2018 Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ. Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nature Communications. 9: 2641. PMID 29980686 DOI: 10.1038/S41467-018-05073-Z  0.41
2018 Li L, Shen X, Liu Z, Norrbom M, Prakash TP, O'Reilly D, Sharma VK, Damha MJ, Watts JK, Rigo F, Corey DR. Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat. Nucleic Acid Therapeutics. PMID 29341839 DOI: 10.1089/Nat.2017.0703  0.72
2018 Hu J, Rong Z, Gong X, Zhou Z, Sharma VK, Xing C, Watts JK, Corey DR, Mootha VV. Oligonucleotides Targeting TCF4 Triplet Repeat Expansion Inhibit RNA Foci and Mis-splicing in Fuchs' Dystrophy. Human Molecular Genetics. PMID 29325021 DOI: 10.1093/Hmg/Ddy018  0.607
2017 Pendergraff HM, Krishnamurthy PM, Debacker AJ, Moazami MP, Sharma VK, Niitsoo L, Yu Y, Tan YN, Haitchi HM, Watts JK. Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA. Molecular Therapy. Nucleic Acids. 8: 158-168. PMID 28918018 DOI: 10.1016/j.omtn.2017.06.012  0.421
2016 Pendergraff HM, Debacker AJ, Watts JK. Single-Stranded Silencing RNAs: Hit Rate and Chemical Modification. Nucleic Acid Therapeutics. PMID 27123752 DOI: 10.1089/nat.2015.0557  0.412
2014 Schaukowitch K, Joo JY, Liu X, Watts JK, Martinez C, Kim TK. Enhancer RNA facilitates NELF release from immediate early genes. Molecular Cell. 56: 29-42. PMID 25263592 DOI: 10.1016/j.molcel.2014.08.023  0.349
2012 Watts JK, Corey DR. Silencing disease genes in the laboratory and the clinic. The Journal of Pathology. 226: 365-79. PMID 22069063 DOI: 10.1002/Path.2993  0.556
2011 Gagnon KT, Watts JK, Pendergraff HM, Montaillier C, Thai D, Potier P, Corey DR. Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates. Journal of the American Chemical Society. 133: 8404-7. PMID 21539318 DOI: 10.1021/Ja200312Y  0.711
2011 Hu J, Gagnon KT, Liu J, Watts JK, Syeda-Nawaz J, Bennett CF, Swayze EE, Randolph J, Chattopadhyaya J, Corey DR. Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biological Chemistry. 392: 315-25. PMID 21294677 DOI: 10.1515/Bc.2011.045  0.709
2011 Anzahaee MY, Watts JK, Alla NR, Nicholson AW, Damha MJ. Energetically important C-H···F-C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity. Journal of the American Chemical Society. 133: 728-31. PMID 21171597 DOI: 10.1021/Ja109817P  0.466
2010 Deleavey GF, Watts JK, Alain T, Robert F, Kalota A, Aishwarya V, Pelletier J, Gewirtz AM, Sonenberg N, Damha MJ. Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing. Nucleic Acids Research. 38: 4547-57. PMID 20413581 DOI: 10.1093/Nar/Gkq181  0.645
2010 Watts JK, Yu D, Charisse K, Montaillier C, Potier P, Manoharan M, Corey DR. Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters. Nucleic Acids Research. 38: 5242-59. PMID 20403811 DOI: 10.1093/Nar/Gkq258  0.628
2010 Watts JK, Corey DR. Clinical status of duplex RNA. Bioorganic & Medicinal Chemistry Letters. 20: 3203-7. PMID 20399650 DOI: 10.1016/J.Bmcl.2010.03.109  0.599
2010 Watts JK, Martín-Pintado N, Gómez-Pinto I, Schwartzentruber J, Portella G, Orozco M, González C, Damha MJ. Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility. Nucleic Acids Research. 38: 2498-511. PMID 20071751 DOI: 10.1093/Nar/Gkp1225  0.557
2009 Deleavey GF, Watts JK, Damha MJ. Chemical modification of siRNA. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 16.3. PMID 20013783 DOI: 10.1002/0471142700.Nc1603S39  0.633
2009 Watts JK, Katolik A, Viladoms J, Damha MJ. Studies on the hydrolytic stability of 2'-fluoroarabinonucleic acid (2'F-ANA). Organic & Biomolecular Chemistry. 7: 1904-10. PMID 19590787 DOI: 10.1039/B900443B  0.579
2008 Watts JK, Deleavey GF, Damha MJ. Chemically modified siRNA: tools and applications. Drug Discovery Today. 13: 842-55. PMID 18614389 DOI: 10.1016/J.Drudis.2008.05.007  0.57
2008 Watts JK, Johnston BD, Jayakanthan K, Wahba AS, Pinto BM, Damha MJ. Synthesis and biophysical characterization of oligonucleotides containing a 4'-selenonucleotide. Journal of the American Chemical Society. 130: 8578-9. PMID 18543920 DOI: 10.1021/Ja802205U  0.577
2007 Watts JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Mario Pinto B, Damha MJ. 2'-Fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Research. 35: 1441-1451. PMID 28383739 DOI: 10.1093/nar/gkl1153  0.607
2007 Watts JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Pinto BM, Damha MJ. 2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Research. 35: 1441-51. PMID 17284457 DOI: 10.1093/Nar/Gkl1153  0.607
2006 Watts JK, Sadalapure K, Choubdar N, Pinto BM, Damha MJ. Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU). The Journal of Organic Chemistry. 71: 921-5. PMID 16438502 DOI: 10.1021/Jo051844+  0.459
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