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Tsutomu Ishihara - Publications

Affiliations: 
1998-2000 College of Engineering Nihon University, Chiyoda-ku, Tōkyō-to, Japan 
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Kihara Y, Maeda R, Imaizumi A, Ichikawa T, Nemoto N, Ishihara T, Hirano N, Haruki M. Alkyne-Functionalized Cationic Polysiloxane Polymers Conjugated with Targeting Molecules by Click Reactions for DNA Delivery Journal of Nanoscience and Nanotechnology. 17: 5081-5089. DOI: 10.1166/Jnn.2017.13121  0.358
2015 Ishihara T, Hayashi E, Yamamoto S, Kobayashi C, Tamura Y, Sawazaki R, Tamura F, Tahara K, Kasahara T, Ishihara T, Takenaga M, Fukuda K, Mizushima T. Encapsulation of beraprost sodium in nanoparticles: analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension. Journal of Controlled Release : Official Journal of the Controlled Release Society. 197: 97-104. PMID 25449809 DOI: 10.1016/J.Jconrel.2014.10.029  0.42
2014 Ishihara T, Kaneko K, Ishihara T, Mizushima T. Development of biodegradable nanoparticles for liver-specific ribavirin delivery. Journal of Pharmaceutical Sciences. 103: 4005-11. PMID 25335768 DOI: 10.1002/Jps.24219  0.457
2014 Kihara Y, Ichikawa T, Abe S, Nemoto N, Ishihara T, Hirano N, Haruki M. Synthesis of alkyne-functionalized amphiphilic polysiloxane polymers and formation of nanoemulsions conjugated with bioactive molecules by click reactions Polymer Journal. 46: 175-183. DOI: 10.1038/Pj.2013.86  0.305
2013 Ishihara T, Yamashita Y, Takasaki N, Yamamoto S, Hayashi E, Tahara K, Takenaga M, Yamakawa N, Ishihara T, Kasahara T, Mizushima T. Prostaglandin E1 -containing nanoparticles improve walking activity in an experimental rat model of intermittent claudication. The Journal of Pharmacy and Pharmacology. 65: 1187-94. PMID 23837586 DOI: 10.1111/Jphp.12080  0.419
2012 Ayano E, Karaki M, Ishihara T, Kanazawa H, Okano T. Poly (N-isopropylacrylamide)-PLA and PLA blend nanoparticles for temperature-controllable drug release and intracellular uptake. Colloids and Surfaces. B, Biointerfaces. 99: 67-73. PMID 22088756 DOI: 10.1016/J.Colsurfb.2011.10.003  0.367
2011 Sakai T, Ishihara T, Higaki M, Akiyama G, Tsuneoka H. Therapeutic effect of stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate on experimental autoimmune uveoretinitis. Investigative Ophthalmology & Visual Science. 52: 1516-21. PMID 21178146 DOI: 10.1167/Iovs.10-5676  0.456
2011 Ishihara T, Kano A, Obara K, Saito M, Chen X, Park TG, Akaike T, Maruyama A. Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates. Journal of Controlled Release : Official Journal of the Controlled Release Society. 155: 34-9. PMID 20955741 DOI: 10.1016/J.Jconrel.2010.10.014  0.407
2010 Horie RT, Sakamoto T, Nakagawa T, Ishihara T, Higaki M, Ito J. Stealth-nanoparticle strategy for enhancing the efficacy of steroids in mice with noise-induced hearing loss. Nanomedicine (London, England). 5: 1331-40. PMID 21128717 DOI: 10.2217/Nnm.10.88  0.433
2010 Ishihara T, Maeda T, Sakamoto H, Takasaki N, Shigyo M, Ishida T, Kiwada H, Mizushima Y, Mizushima T. Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers. Biomacromolecules. 11: 2700-6. PMID 20795699 DOI: 10.1021/Bm100754E  0.426
2010 Ishihara T, Mizushima T. Techniques for efficient entrapment of pharmaceuticals in biodegradable solid micro/nanoparticles. Expert Opinion On Drug Delivery. 7: 565-75. PMID 20230305 DOI: 10.1517/17425241003713486  0.322
2010 Ishihara T, Takahashi M, Higaki M, Mizushima Y, Mizushima T. Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents. International Journal of Pharmaceutics. 385: 170-5. PMID 19837147 DOI: 10.1016/J.Ijpharm.2009.10.025  0.439
2009 Matsuo Y, Ishihara T, Ishizaki J, Miyamoto K, Higaki M, Yamashita N. Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model. Cellular Immunology. 260: 33-8. PMID 19716124 DOI: 10.1016/J.Cellimm.2009.07.004  0.312
2009 Ishihara T, Takeda M, Sakamoto H, Kimoto A, Kobayashi C, Takasaki N, Yuki K, Tanaka K, Takenaga M, Igarashi R, Maeda T, Yamakawa N, Okamoto Y, Otsuka M, Ishida T, et al. Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles. Pharmaceutical Research. 26: 2270-9. PMID 19633820 DOI: 10.1007/S11095-009-9943-X  0.429
2009 Ishihara T, Goto M, Kodera K, Kanazawa H, Murakami Y, Mizushima Y, Higaki M. Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides. Drug Delivery. 16: 153-9. PMID 19514975 DOI: 10.1080/10717540902722774  0.329
2009 Ishihara T, Kubota T, Choi T, Takahashi M, Ayano E, Kanazawa H, Higaki M. Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness. International Journal of Pharmaceutics. 375: 148-54. PMID 19481700 DOI: 10.1016/J.Ijpharm.2009.04.001  0.468
2009 Takeda M, Maeda T, Ishihara T, Sakamoto H, Yuki K, Takasaki N, Nishimura F, Yamashita T, Tanaka K, Takenaga M, Igarashi R, Higaki M, Yamakawa N, Okamoto Y, Ogawa H, et al. Synthesis of prostaglandin E(1) phosphate derivatives and their encapsulation in biodegradable nanoparticles. Pharmaceutical Research. 26: 1792-800. PMID 19415470 DOI: 10.1007/S11095-009-9891-5  0.378
2009 Ishihara T, Kubota T, Choi T, Higaki M. Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate. The Journal of Pharmacology and Experimental Therapeutics. 329: 412-7. PMID 19244548 DOI: 10.1124/Jpet.108.150276  0.417
2009 Ishihara T, Goto M, Kanazawa H, Higaki M, Mizushima Y. Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles. Journal of Pharmaceutical Sciences. 98: 2357-63. PMID 18979534 DOI: 10.1002/Jps.21605  0.44
2009 Ishihara T, Takahashi M, Higaki M, Mizushima Y. Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles. International Journal of Pharmaceutics. 365: 200-5. PMID 18804157 DOI: 10.1016/J.Ijpharm.2008.08.030  0.46
2008 Ishihara T, Takahashi M, Higaki M, Takenaga M, Mizushima T, Mizushima Y. Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles. Pharmaceutical Research. 25: 1686-95. PMID 18293063 DOI: 10.1007/S11095-008-9549-8  0.404
2006 Higaki M, Kameyama M, Udagawa M, Ueno Y, Yamaguchi Y, Igarashi R, Ishihara T, Mizushima Y. Transdermal delivery of CaCO3-nanoparticles containing insulin. Diabetes Technology & Therapeutics. 8: 369-74. PMID 16800758 DOI: 10.1089/Dia.2006.8.369  0.358
2006 Sakai T, Kohno H, Ishihara T, Higaki M, Saito S, Matsushima M, Mizushima Y, Kitahara K. Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate. Experimental Eye Research. 82: 657-63. PMID 16360654 DOI: 10.1016/J.Exer.2005.09.003  0.371
2005 Tamura T, Kita T, Nakagawa T, Endo T, Kim TS, Ishihara T, Mizushima Y, Higaki M, Ito J. Drug delivery to the cochlea using PLGA nanoparticles. The Laryngoscope. 115: 2000-5. PMID 16319613 DOI: 10.1097/01.Mlg.0000180174.81036.5A  0.435
2005 Ishihara T, Izumo N, Higaki M, Shimada E, Hagi T, Mine L, Ogawa Y, Mizushima Y. Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile. Journal of Controlled Release : Official Journal of the Controlled Release Society. 105: 68-76. PMID 15955367 DOI: 10.1016/J.Jconrel.2005.02.026  0.446
2005 Higaki M, Ishihara T, Izumo N, Takatsu M, Mizushima Y. Treatment of experimental arthritis with poly(D, L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate. Annals of the Rheumatic Diseases. 64: 1132-1136. PMID 15695536 DOI: 10.1136/Ard.2004.030759  0.402
2004 Goto M, Ishihara T, Higaki M, Mizushima Y, Kanazawa H. Preparation of nanoparticles covered with inorganic compound as a drug carrier. Journal of Life Support Engineering. 16: 183-184. DOI: 10.5136/Lifesupport.16.Supplement_183  0.383
2001 Kim WJ, Ishihara T, Akaike T, Maruyama A. Comb-type cationic copolymer expedites DNA strand exchange while stabilizing DNA duplex Chemistry: a European Journal. 7: 176-180. PMID 11205009 DOI: 10.1002/1521-3765(20010105)7:1<176::Aid-Chem176>3.0.Co;2-M  0.359
2001 Cho CS, Kobayashi A, Takei R, Ishihara T, Maruyama A, Akaike T. Receptor-mediated cell modulator delivery to hepatocyte using nanoparticles coated with carbohydrate-carrying polymers. Biomaterials. 22: 45-51. PMID 11085382 DOI: 10.1016/S0142-9612(00)00143-5  0.417
2000 Zhang X, Ishihara T, Corey DR. Strand invasion by mixed base PNAs and a PNA-peptide chimera. Nucleic Acids Research. 28: 3332-8. PMID 10954602 DOI: 10.1093/Nar/28.17.3332  0.555
2000 Ishihara T, Akaike T, Maruyama A. Biomaterials for gene delivery Drug Delivery System. 15: 106-112. DOI: 10.2745/Dds.15.106  0.396
1999 Ishihara T, Corey DR. Strand invasion by DNA-peptide conjugates and peptide nucleic acids. Nucleic Acids Symposium Series. 141-2. PMID 10780419  0.509
1999 Park JU, Ishihara T, Kano A, Akaike T, Maruyama A. Preparation of dendritic graft copolymer consisting of poly-(L-lysine) and arabinogalactan as a hepatocyte specific DNA carrier. Preparative Biochemistry & Biotechnology. 29: 353-70. PMID 10548252 DOI: 10.1080/10826069908544934  0.363
1999 Maruyama A, Ferdous A, Ishihara T, Asayama S, Park JU, Nogawa M, Watanabe H, Takei Y, Akaike T. Comb-type copolymers for controlled DNA delivery. Nucleosides & Nucleotides. 18: 1681-2. PMID 10474245 DOI: 10.1080/07328319908044821  0.424
1999 Ishihara T, Corey DR. Rules for strand invasion by chemically modified oligonucleotides Journal of the American Chemical Society. 121: 2012-2020. DOI: 10.1021/Ja983834E  0.554
1999 Maruyama A, Ishihara T, Kim JS, Kim SW, Akaike T. Design of multi-functional nanoparticles as a DNA carrier Colloids and Surfaces a: Physicochemical and Engineering Aspects. 153: 439-443. DOI: 10.1016/S0927-7757(98)00534-2  0.443
1998 Maruyama A, Watanabe H, Ferdous A, Katoh M, Ishihara T, Akaike T. Characterization of interpolyelectrolyte complexes between double-stranded DNA and polylysine comb-type copolymers having hydrophilic side chains Bioconjugate Chemistry. 9: 292-299. PMID 9548547 DOI: 10.1021/Bc9701510  0.347
1997 Maruyama A, Ishihara T, Kim JS, Kim SW, Akaike T. Nanoparticle DNA Carrier with Poly(l-lysine) Grafted Polysaccharide Copolymer and Poly(d,l-lactic acid) Bioconjugate Chemistry. 8: 735-742. PMID 9327139 DOI: 10.1021/Bc9701048  0.434
1997 Cho CS, Jeong YI, Ishihara T, Takei R, Park JU, Park KH, Maruyama A, Akaike T. Simple preparation of nanoparticles coated with carbohydrate-carrying polymers. Biomaterials. 18: 323-6. PMID 9068894 DOI: 10.1016/S0142-9612(96)00138-X  0.416
1997 Maruyama A, Katoh M, Ishihara T, Akaike T. Comb-type polycations effectively stabilize DNA triplex. Bioconjugate Chemistry. 8: 3-6. PMID 9026028 DOI: 10.1021/Bc960071G  0.365
1994 Maruyama A, Ishihara T, Adachi N, Akaike T. Preparation of nanoparticles bearing high density carbohydrate chains using carbohydrate-carrying polymers as emulsifier Biomaterials. 15: 1035-1042. PMID 7888573 DOI: 10.1016/0142-9612(94)90088-4  0.39
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