| Year |
Citation |
Score |
| 2024 |
Lee JY, Gebauer E, Seeliger MA, Bahar I. Allo-targeting of the kinase domain: Insights from in silico studies and comparison with experiments. Current Opinion in Structural Biology. 84: 102770. PMID 38211377 DOI: 10.1016/j.sbi.2023.102770 |
0.39 |
|
| 2023 |
Outhwaite IR, Singh S, Berger BT, Knapp S, Chodera JD, Seeliger MA. Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting. Elife. 12. PMID 38047771 DOI: 10.7554/eLife.86189 |
0.748 |
|
| 2023 |
Outhwaite IR, Seeliger MA. Probing conformational dynamics to understand kinase inhibition. Elife. 12. PMID 37850630 DOI: 10.7554/eLife.92753 |
0.533 |
|
| 2023 |
Ayaz P, Lyczek A, Paung Y, Mingione VR, Iacob RE, de Waal PW, Engen JR, Seeliger MA, Shan Y, Shaw DE. Structural mechanism of a drug-binding process involving a large conformational change of the protein target. Nature Communications. 14: 1885. PMID 37019905 DOI: 10.1038/s41467-023-36956-5 |
0.436 |
|
| 2023 |
Kan Y, Paung Y, Seeliger MA, Miller WT. Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1. Cells. 12. PMID 36980241 DOI: 10.3390/cells12060900 |
0.522 |
|
| 2023 |
Kan Y, Paung Y, Kim Y, Seeliger MA, Miller WT. Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk. Biochemistry. PMID 36854171 DOI: 10.1021/acs.biochem.2c00685 |
0.443 |
|
| 2023 |
Mingione VR, Paung Y, Outhwaite IR, Seeliger MA. Allosteric regulation and inhibition of protein kinases. Biochemical Society Transactions. 51: 373-385. PMID 36794774 DOI: 10.1042/BST20220940 |
0.55 |
|
| 2023 |
Outhwaite IR, Singh S, Berger BT, Knapp S, Chodera JD, Seeliger MA. Death by a Thousand Cuts â€" Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology. Biorxiv : the Preprint Server For Biology. PMID 36711619 DOI: 10.1101/2023.01.13.523972 |
0.756 |
|
| 2022 |
Sridaran D, Chouhan S, Mahajan K, Renganathan A, Weimholt C, Bhagwat S, Reimers M, Kim EH, Thakur MK, Saeed MA, Pachynski RK, Seeliger MA, Todd Miller W, Feng FY, Mahajan NP. Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Nature Communications. 13: 6929. PMID 36376335 DOI: 10.1038/s41467-022-34724-5 |
0.433 |
|
| 2022 |
Peterson AA, Rangwala AM, Thakur MK, Ward PS, Hung C, Outhwaite IR, Chan AI, Usanov DL, Mootha VK, Seeliger MA, Liu DR. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nature Chemical Biology. PMID 36163383 DOI: 10.1038/s41589-022-01116-1 |
0.307 |
|
| 2022 |
Rangwala AM, Mingione VR, Georghiou G, Seeliger MA. Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome. Biomolecules. 12. PMID 35625613 DOI: 10.3390/biom12050685 |
0.817 |
|
| 2022 |
Mingione VR, Foda ZH, Paung Y, Philipose H, Rangwala AM, Shan Y, Seeliger MA. Validation of an Allosteric Binding Site of Src Kinase Identified by Unbiased Ligand Binding Simulations. Journal of Molecular Biology. 167628. PMID 35595169 DOI: 10.1016/j.jmb.2022.167628 |
0.385 |
|
| 2022 |
Rangwala AM, Berger BT, Robers MB, Knapp S, Seeliger MA. Resistance to kinase inhibition through shortened target engagement. Molecular & Cellular Oncology. 9: 2029999. PMID 35252553 DOI: 10.1080/23723556.2022.2029999 |
0.445 |
|
| 2021 |
Lyczek A, Berger BT, Rangwala AM, Paung Y, Tom J, Philipose H, Guo J, Albanese SK, Robers MB, Knapp S, Chodera JD, Seeliger MA. Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34750265 DOI: 10.1073/pnas.2111451118 |
0.632 |
|
| 2020 |
Fang L, Vilas-Boas J, Chakraborty S, Potter ZE, Register AC, Seeliger MA, Maly DJ. How ATP-competitive inhibitors allosterically modulate tyrosine kinases that contain a Src-like regulatory architecture. Acs Chemical Biology. PMID 32479050 DOI: 10.1021/Acschembio.0C00429 |
0.657 |
|
| 2020 |
Grey MJ, Cloots E, Simpson MS, LeDuc N, Serebrenik YV, De Luca H, De Sutter D, Luong P, Thiagarajah JR, Paton AW, Paton JC, Seeliger MA, Eyckerman S, Janssens S, Lencer WI. IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress. The Journal of Cell Biology. 219. PMID 31985747 DOI: 10.1083/Jcb.201904048 |
0.328 |
|
| 2019 |
Maianti JP, Tan GA, Vetere A, Welsh AJ, Wagner BK, Seeliger MA, Liu DR. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nature Chemical Biology. PMID 31086331 DOI: 10.1038/S41589-019-0271-0 |
0.341 |
|
| 2019 |
Wang J, Chan B, Tong M, Paung Y, Jo U, Martin D, Seeliger M, Haley J, Kim H. Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway. Plos Genetics. 15: e1007983. PMID 30789902 DOI: 10.1371/Journal.Pgen.1007983 |
0.343 |
|
| 2018 |
Hanson SM, Georghiou G, Thakur MK, Miller WT, Rest JS, Chodera JD, Seeliger MA. What Makes a Kinase Promiscuous for Inhibitors? Cell Chemical Biology. PMID 30612951 DOI: 10.1016/J.Chembiol.2018.11.005 |
0.82 |
|
| 2018 |
Seeliger MA. More Diversity Yields a Clearer Picture into the Architecture of the Protein Kinase Domain. Cell Systems. 7: 356-357. PMID 30359621 DOI: 10.1016/J.Cels.2018.10.002 |
0.56 |
|
| 2018 |
Paung Y, Seeliger MA. KA1 Domains: Unity in Mechanistic Diversity. Structure (London, England : 1993). 26: 1045-1047. PMID 30089246 DOI: 10.1016/J.Str.2018.07.002 |
0.561 |
|
| 2018 |
Albanese SK, Parton DL, Isik M, Rodríguez-Laureano L, Hanson SM, Behr JM, Gradia S, Jeans C, Levinson NM, Seeliger MA, Chodera JD. An open library of human kinase domain constructs for automated bacterial expression. Biochemistry. PMID 30004690 DOI: 10.1021/Acs.Biochem.7B01081 |
0.805 |
|
| 2017 |
Tong M, Pelton JG, Gill ML, Zhang W, Picart F, Seeliger MA. Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites. Nature Communications. 8: 2160. PMID 29255153 DOI: 10.1038/S41467-017-02240-6 |
0.66 |
|
| 2017 |
Alford VM, Kamath A, Ren X, Kumar K, Gan Q, Awwa M, Tong M, Seeliger MA, Cao J, Ojima I, Sampson NS. Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions. Acs Chemical Biology. PMID 28945333 DOI: 10.1021/Acschembio.7B00758 |
0.445 |
|
| 2017 |
Kükenshöner T, Schmit NE, Bouda E, Sha F, Pojer F, Koide A, Seeliger M, Koide S, Hantschel O. Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. Journal of Molecular Biology. PMID 28347651 DOI: 10.1016/J.Jmb.2017.03.023 |
0.538 |
|
| 2016 |
Chu WT, Nesbitt NM, Gnatenko DV, Li Z, Zhang B, Seeliger MA, Browne S, Mantle TJ, Bahou WF, Wang J. Enzymatic activity and thermodynamic stability of biliverdin IXβ reductase are maintained by an active site serine. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27897348 DOI: 10.1002/Chem.201604517 |
0.393 |
|
| 2016 |
Huculeci R, Cilia E, Lyczek A, Buts L, Houben K, Seeliger MA, van Nuland N, Lenaerts T. Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure (London, England : 1993). PMID 27692963 DOI: 10.1016/j.str.2016.08.016 |
0.453 |
|
| 2016 |
Aleem SU, Georghiou G, Kleiner RE, Guja KE, Craddock BP, Lyczek A, Chan AI, Garcia-Diaz M, Miller WT, Liu DR, Seeliger MA. Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. Cell Chemical Biology. PMID 27593110 DOI: 10.1016/J.Chembiol.2016.07.017 |
0.845 |
|
| 2016 |
Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ. Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands. Acs Chemical Biology. PMID 27227314 DOI: 10.1021/Acschembio.5B00940 |
0.589 |
|
| 2016 |
Kwarcinski FE, Brandvold KR, Phadke S, Beleh OM, Johnson TK, Meagher JL, Seeliger MA, Stuckey JA, Soellner MB. Conformation-selective analogs of dasatinib reveal insight into kinase inhibitor binding and selectivity. Acs Chemical Biology. PMID 26895387 DOI: 10.1021/Acschembio.5B01018 |
0.594 |
|
| 2016 |
Hanson SM, Rodriguez L, Behr JM, Rizzi A, Parton DL, Beauchamp KA, Fass JH, Prinz J, Boyce SE, Seeliger MA, Levinson NM, Chodera JD. Dissecting the Contribution of Kinase Conformational Reorganization Energies to Inhibitor Selectivity Biophysical Journal. 110: 545a. DOI: 10.1016/J.Bpj.2015.11.2918 |
0.808 |
|
| 2015 |
Foda ZH, Shan Y, Kim ET, Shaw DE, Seeliger MA. A dynamically coupled allosteric network underlies binding cooperativity in Src kinase. Nature Communications. 6: 5939. PMID 25600932 DOI: 10.1038/Ncomms6939 |
0.658 |
|
| 2015 |
Tong M, Seeliger MA. Targeting conformational plasticity of protein kinases. Acs Chemical Biology. 10: 190-200. PMID 25486330 DOI: 10.1021/Cb500870A |
0.658 |
|
| 2014 |
Foda ZH, Seeliger MA. Kinase inhibitors: an allosteric add-on. Nature Chemical Biology. 10: 796-7. PMID 25195010 DOI: 10.1038/Nchembio.1630 |
0.659 |
|
| 2014 |
Etheridge SL, Cosgrove ME, Sangkhae V, Corbo LM, Roh ME, Seeliger MA, Chan EL, Hitchcock IS. A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis. Blood. 123: 1059-68. PMID 24381227 DOI: 10.1182/Blood-2012-12-473777 |
0.336 |
|
| 2014 |
Seeliger MA, Moll UM. p73 - constitutively open for business. Cell Death and Differentiation. 20: 972-3. PMID 23832148 DOI: 10.1038/Cdd.2013.56 |
0.317 |
|
| 2013 |
Hari SB, Perera BG, Ranjitkar P, Seeliger MA, Maly DJ. Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src. Acs Chemical Biology. 8: 2734-43. PMID 24106839 DOI: 10.1021/Cb400663K |
0.665 |
|
| 2013 |
Schultheiss KP, Craddock BP, Tong M, Seeliger M, Miller WT. Metazoan-like signaling in a unicellular receptor tyrosine kinase. Bmc Biochemistry. 14: 4. PMID 23398683 DOI: 10.1186/1471-2091-14-4 |
0.499 |
|
| 2012 |
Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nature Chemical Biology. 8: 982-9. PMID 23086298 DOI: 10.1038/Nchembio.1094 |
0.575 |
|
| 2012 |
Georghiou G, Kleiner RE, Pulkoski-Gross M, Liu DR, Seeliger MA. Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles. Nature Chemical Biology. 8: 366-74. PMID 22344177 DOI: 10.1038/Nchembio.792 |
0.833 |
|
| 2011 |
Shan Y, Kim ET, Eastwood MP, Dror RO, Seeliger MA, Shaw DE. How does a drug molecule find its target binding site? Journal of the American Chemical Society. 133: 9181-3. PMID 21545110 DOI: 10.1021/Ja202726Y |
0.442 |
|
| 2011 |
Jura N, Zhang X, Endres NF, Seeliger MA, Schindler T, Kuriyan J. Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms Molecular Cell. 42: 9-22. PMID 21474065 DOI: 10.1016/J.Molcel.2011.03.004 |
0.799 |
|
| 2010 |
Weisberg E, Choi HG, Ray A, Barrett R, Zhang J, Sim T, Zhou W, Seeliger M, Cameron M, Azam M, Fletcher JA, Debiec-Rychter M, Mayeda M, Moreno D, Kung AL, et al. Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants. Blood. 115: 4206-16. PMID 20299508 DOI: 10.1182/Blood-2009-11-251751 |
0.594 |
|
| 2009 |
Choi Y, Seeliger MA, Panjarian SB, Kim H, Deng X, Sim T, Couch B, Koleske AJ, Smithgall TE, Gray NS. N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor. The Journal of Biological Chemistry. 284: 29005-14. PMID 19679652 DOI: 10.1074/Jbc.M109.026633 |
0.654 |
|
| 2009 |
Seeliger MA, Kuriyan J. A MAPK Scaffold Lends a Helping Hand Cell. 136: 994-996. PMID 19303841 DOI: 10.1016/J.Cell.2009.03.002 |
0.636 |
|
| 2009 |
Seeliger MA, Ranjitkar P, Kasap C, Shan Y, Shaw DE, Shah NP, Kuriyan J, Maly DJ. Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations Cancer Research. 69: 2384-2392. PMID 19276351 DOI: 10.1158/0008-5472.Can-08-3953 |
0.729 |
|
| 2009 |
Muratore KE, Seeliger MA, Wang Z, Fomina D, Neiswinger J, Havranek JJ, Baker D, Kuriyan J, Cole PA. Comparative analysis of mutant tyrosine kinase chemical rescue. Biochemistry. 48: 3378-86. PMID 19260709 DOI: 10.1021/Bi900057G |
0.732 |
|
| 2009 |
Shan Y, Seeliger MA, Eastwood MP, Frank F, Xu H, Jensen MØ, Dror RO, Kuriyan J, Shaw DE. A conserved protonation-dependent switch controls drug binding in the Abl kinase. Proceedings of the National Academy of Sciences of the United States of America. 106: 139-44. PMID 19109437 DOI: 10.1073/Pnas.0811223106 |
0.742 |
|
| 2008 |
Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH, Lockhart DJ, Zarrinkar PP, Kuriyan J, Shokat KM. Tuning a three-component reaction for trapping kinase substrate complexes. Journal of the American Chemical Society. 130: 17568-74. PMID 19053485 DOI: 10.1021/Ja807066F |
0.723 |
|
| 2008 |
Azam M, Seeliger MA, Gray NS, Kuriyan J, Daley GQ. Activation of tyrosine kinases by mutation of the gatekeeper threonine Nature Structural and Molecular Biology. 15: 1109-1118. PMID 18794843 DOI: 10.1038/Nsmb.1486 |
0.737 |
|
| 2008 |
Levinson NM, Seeliger MA, Cole PA, Kuriyan J. Structural Basis for the Recognition of c-Src by Its Inactivator Csk Cell. 134: 124-134. PMID 18614016 DOI: 10.1016/J.Cell.2008.05.051 |
0.811 |
|
| 2008 |
Azam M, Seeliger M, Powers JT, Gray N, Kuriyan J, Daley GQ. Inhibition of BCR/ABL-T315I by Dismantling the Hydrophobic Spine. Blood. 112: 2129-2129. DOI: 10.1182/Blood.V112.11.2129.2129 |
0.484 |
|
| 2007 |
Seeliger MA, Nagar B, Frank F, Cao X, Henderson MN, Kuriyan J. c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty Structure. 15: 299-311. PMID 17355866 DOI: 10.1016/J.Str.2007.01.015 |
0.764 |
|
| 2007 |
Azam M, Seeliger M, Gray NS, Kuriyan J, Daley GQ. A Unified Mechanism of Tyrosine Kinase Regulation by the Gatekeeper Residue. Blood. 110: 223-223. DOI: 10.1182/Blood.V110.11.223.223 |
0.778 |
|
| 2006 |
Yao ZP, Zhou M, Kelly SE, Seeliger MA, Robinson CV, Itzhaki LS. Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry. Journal of Molecular Biology. 363: 673-86. PMID 16979657 DOI: 10.1016/J.Jmb.2006.08.032 |
0.431 |
|
| 2006 |
Bader R, Seeliger MA, Kelly SE, Ilag LL, Meersman F, Limones A, Luisi BF, Dobson CM, Itzhaki LS. Folding and fibril formation of the cell cycle protein Cks1. The Journal of Biological Chemistry. 281: 18816-24. PMID 16675442 DOI: 10.1074/Jbc.M603628200 |
0.302 |
|
| 2006 |
Nagar B, Hantschel O, Seeliger M, Davies JM, Weis WI, Superti-Furga G, Kuriyan J. Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase Molecular Cell. 21: 787-798. PMID 16543148 DOI: 10.1016/J.Molcel.2006.01.035 |
0.787 |
|
| 2006 |
Young MA, Shah NP, Chao LH, Seeliger M, Milanov ZV, Biggs WH, Treiber DK, Patel HK, Zarrinkar PP, Lockhart DJ, Sawyers CL, Kuriyan J. Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Research. 66: 1007-14. PMID 16424036 DOI: 10.1158/0008-5472.Can-05-2788 |
0.817 |
|
| 2005 |
Seeliger MA, Young M, Henderson MN, Pellicena P, King DS, Falick AM, Kuriyan J. High yield bacterial expression of active c-Abl and c-Src tyrosine kinases Protein Science. 14: 3135-3139. PMID 16260764 DOI: 10.1110/Ps.051750905 |
0.745 |
|
| 2005 |
Seeliger MA, Spichty M, Kelly SE, Bycroft M, Freund SM, Karplus M, Itzhaki LS. Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins. The Journal of Biological Chemistry. 280: 30448-59. PMID 15772084 DOI: 10.1074/Jbc.M501450200 |
0.509 |
|
| 2005 |
Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A. Mechanism of CDK5/p25 binding by CDK inhibitors. Journal of Medicinal Chemistry. 48: 671-9. PMID 15689152 DOI: 10.1021/Jm049323M |
0.542 |
|
| 2004 |
Seeliger MA, Breward SE, Friedler A, Schon O, Itzhaki LS. Erratum: Cooperative organization in a macromolecular complex Nature Structural & Molecular Biology. 11: 678-678. DOI: 10.1038/Nsmb0704-678B |
0.534 |
|
| 2003 |
Seeliger MA, Breward SE, Friedler A, Schon O, Itzhaki LS. Cooperative organization in a macromolecular complex. Nature Structural Biology. 10: 718-24. PMID 12897769 DOI: 10.1038/Nsb962 |
0.578 |
|
| 2002 |
Sitry D, Seeliger MA, Ko TK, Ganoth D, Breward SE, Itzhaki LS, Pagano M, Hershko A. Three different binding sites of Cks1 are required for p27-ubiquitin ligation. The Journal of Biological Chemistry. 277: 42233-40. PMID 12140288 DOI: 10.1074/Jbc.M205254200 |
0.434 |
|
| 2002 |
Seeliger MA, Schymkowitz JW, Rousseau F, Wilkinson HR, Itzhaki LS. Folding and association of the human cell cycle regulatory proteins ckshs1 and ckshs2. Biochemistry. 41: 1202-10. PMID 11802719 DOI: 10.1021/Bi0113465 |
0.353 |
|
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