Zilai Wang - Related publications

Affiliations: 
Baylor College of Medicine, Houston, TX 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Chen F, Fang S, Du Y, Ghosh A, Reed MN, Long Y, Suppiramaniam V, Tang S, Hong H. CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 mice. Aging. 13. PMID 33591941 DOI: 10.18632/aging.202501   
2021 Liu X, Wang K, Wei X, Xie T, Lv B, Zhou Q, Wang X. Interaction of NF-κB and Wnt/β-catenin Signaling Pathways in Alzheimer's Disease and Potential Active Drug Treatments. Neurochemical Research. PMID 33523396 DOI: 10.1007/s11064-021-03227-y   
2021 Ulm BS, Borchelt DR, Moore BD. Remodeling Alzheimer-amyloidosis models by seeding. Molecular Neurodegeneration. 16: 8. PMID 33588898 DOI: 10.1186/s13024-021-00429-4   
2021 Lee SB, Park A, Ma CT, Kim YH, Yang HO. 3'-O-Acetyl-24-Epi-7,8-Didehydrocimigenol-3-O-β-D-Xylopryranoside Decreases Amyloid Beta Production in Amyloid Precursor Protein-Transfected HeLa Cells. Biomolecules & Therapeutics. PMID 33619237 DOI: 10.4062/biomolther.2020.195   
2021 Hashimoto Y, Kusakari S, Nawa M, Okamoto K, Toyama Y, Matsuoka M. Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease. Translational Psychiatry. 11: 44. PMID 33441550 DOI: 10.1038/s41398-020-01168-8   
2021 Goldstein LSB, Das U. The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention? Progress in Molecular Biology and Translational Science. 177: 109-122. PMID 33453937 DOI: 10.1016/bs.pmbts.2020.08.001   
2021 Zheng X, Lin W, Jiang Y, Lu K, Wei W, Huo Q, Cui S, Yang X, Li M, Xu N, Tang C, Song JX. Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB). Autophagy. 1-15. PMID 33622188 DOI: 10.1080/15548627.2021.1886720   
2021 Ly H, Verma N, Sharma S, Kotiya D, Despa S, Abner EL, Nelson PT, Jicha GA, Wilcock DM, Goldstein LB, Guerreiro R, Brás J, Hanson AJ, Craft S, Murray AJ, et al. The association of circulating amylin with β-amyloid in familial Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 7: e12130. PMID 33521236 DOI: 10.1002/trc2.12130   
2021 Lau JKY, Tian M, Shen Y, Lau SF, Fu WY, Fu AKY, Ip NY. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer's disease transgenic mouse model. Scientific Reports. 11: 4359. PMID 33623128 DOI: 10.1038/s41598-021-83932-4   
2021 Wolfe MS. Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer's Disease. Molecules (Basel, Switzerland). 26. PMID 33450968 DOI: 10.3390/molecules26020388   
2021 Liu L, Lauro BM, Wolfe MS, Selkoe DJ. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides. The Journal of Biological Chemistry. 100393. PMID 33571524 DOI: 10.1016/j.jbc.2021.100393   
2021 Zimmer JA, Shcherbinin S, Devous MD, Bragg SM, Selzler KJ, Wessels AM, Shering C, Mullen J, Landry J, Andersen SW, Downing AM, Fleisher AS, Svaldi DO, Sims JR. Lanabecestat: Neuroimaging results in early symptomatic Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 7: e12123. PMID 33614894 DOI: 10.1002/trc2.12123   
2021 Xie QQ, Feng X, Huang YΥ, Fang N, Yi H, Wang ZJ, Cao QΥ, Lou GF, Pan JP, Hu Y, Li FC, Zheng Q, Xiao F. Nogo‑66 promotes β‑amyloid protein secretion via NgR/ROCK‑dependent BACE1 activation. Molecular Medicine Reports. 23. PMID 33495810 DOI: 10.3892/mmr.2021.11827   
2021 Locci A, Orellana H, Rodriguez G, Gottliebson M, McClarty B, Dominguez S, Keszycki R, Dong H. Comparison of memory, affective behavior, and neuropathology in APP knock-in mice to 5xFAD and APP/PS1 mice. Behavioural Brain Research. 113192. PMID 33607163 DOI: 10.1016/j.bbr.2021.113192   
2021 Stojakovic A, Trushin S, Sheu A, Khalili L, Chang SY, Li X, Christensen T, Salisbury JL, Geroux RE, Gateno B, Flannery PJ, Dehankar M, Funk CC, Wilkins J, Stepanova A, et al. Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice. Communications Biology. 4: 61. PMID 33420340 DOI: 10.1038/s42003-020-01584-y   
2021 Kedia S, Ramakrishna P, Netrakanti PR, Singh N, Sisodia SS, Jose M, Kumar S, Mahadevan A, Ramanan N, Nadkarni S, Nair D. Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease. Iscience. 24: 101924. PMID 33409475 DOI: 10.1016/j.isci.2020.101924   
2021 Bartling CRO, Jensen TMT, Henry SM, Colliander AL, Sereikaite V, Wenzler M, Jain P, Maric HM, Harpsøe K, Pedersen SW, Clemmensen LS, Haugaard-Kedström LM, Gloriam DE, Ho A, Strømgaard K. Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation. Journal of the American Chemical Society. PMID 33398998 DOI: 10.1021/jacs.0c10696   
2021 Lee ZF, Huang TH, Chen SP, Cheng IH. Altered nociception in Alzheimer's disease is associated with STEP signaling. Pain. PMID 33433143 DOI: 10.1097/j.pain.0000000000002180   
2021 Li N, Zhang X, Gu Z, Su C, Lian H. Young plasma attenuates cognitive impairment and the cortical hemorrhage area in cerebral amyloid angiopathy model mice. Annals of Translational Medicine. 9: 147. PMID 33569449 DOI: 10.21037/atm-20-8008   
2021 Li N, Zhang X, Gu Z, Su C, Lian H. Young plasma attenuates cognitive impairment and the cortical hemorrhage area in cerebral amyloid angiopathy model mice. Annals of Translational Medicine. 9: 147. PMID 33569449 DOI: 10.21037/atm-20-8008   
2021 Sahu B, Mackos AR, Floden AM, Wold LE, Combs CK. Particulate Matter Exposure Exacerbates Amyloid-β Plaque Deposition and Gliosis in APP/PS1 Mice. Journal of Alzheimer's Disease : Jad. PMID 33554902 DOI: 10.3233/JAD-200919   
2021 Chakraborty S, Rakshit J, Bandyopadhyay J, Basu S. Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer's disease therapeutics. International Journal of Biological Macromolecules. PMID 33581209 DOI: 10.1016/j.ijbiomac.2021.02.073   
2021 Keshavan A, Wellington H, Chen Z, Khatun A, Chapman M, Hart M, Cash DM, Coath W, Parker TD, Buchanan SM, Keuss SE, Harris MJ, Murray-Smith H, Heslegrave A, Fox NC, et al. Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12131. PMID 33598527 DOI: 10.1002/dad2.12131   
2021 Park JC, Jung KS, Kim J, Jang JS, Kwon S, Byun MS, Yi D, Byeon G, Jung G, Kim YK, Lee DY, Han SH, Mook-Jung I. Performance of the QPLEX™ Alz plus assay, a novel multiplex kit for screening cerebral amyloid deposition. Alzheimer's Research & Therapy. 13: 12. PMID 33407839 DOI: 10.1186/s13195-020-00751-x   
2021 Decker Y, Németh E, Schomburg R, Chemla A, Fülöp L, Menger MD, Liu Y, Fassbender K. Decreased pH in the aging brain and Alzheimer's disease. Neurobiology of Aging. 101: 40-49. PMID 33578193 DOI: 10.1016/j.neurobiolaging.2020.12.007   
2021 Do HQ, Hewetson A, Borcik CG, Hastert MC, Whelly S, Wylie BJ, Sutton RB, Cornwall GA. Cross-seeding Between the Functional Amyloidogenic CRES and CRES3 Family Members and their Regulation of Aβ Assembly. The Journal of Biological Chemistry. 100250. PMID 33428930 DOI: 10.1074/jbc.RA120.015307   
2021 Duan W, Zou J, Chen X, Xiao C, Jiang W. Biglycan Expression Promotes β-Amyloid-Induced Microglial Activation via TLR2 in Mouse Cell Culture Model. Clinical Laboratory. 67. PMID 33491410 DOI: 10.7754/Clin.Lab.2020.200252   
2021 Jiang H, Niu F, Zheng Y, Xu Y. CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes. Molecular Medicine Reports. 23: 1-12. PMID 33604684 DOI: 10.3892/mmr.2021.11919   
2021 Cheng F, Fransson LÅ, Mani K. Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1. Glycobiology. PMID 33403386 DOI: 10.1093/glycob/cwaa120   
2021 Li D, Liu C. Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease. Nature Chemical Biology. PMID 33432239 DOI: 10.1038/s41589-020-00708-z   
2021 Fonar G, Polis B, Sams DS, Levi A, Malka A, Bal N, Maltsev A, Elliott E, Samson AO. Modified Snake α-Neurotoxin Averts β-Amyloid Binding to α7 Nicotinic Acetylcholine Receptor and Reverses Cognitive Deficits in Alzheimer's Disease Mice. Molecular Neurobiology. PMID 33417228 DOI: 10.1007/s12035-020-02270-0   
2021 Yu W, Jin H, Huang Y. Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer's disease. Clinical Science (London, England : 1979). 135: 109-126. PMID 33404051 DOI: 10.1042/CS20200844   
2021 Wang H, Yue Y, Zhao H, Wu H, Jiang K, Li S, Zhao M, Lin F. Neuroprotective Effects of 2-Substituted 1, 3-Selenazole Amide Derivatives on Amyloid-Beta-Induced Toxicity in a Transgenic Caenorhabditis Elegans Model of Alzheimer's Disease. Neurotoxicity Research. PMID 33400180 DOI: 10.1007/s12640-020-00321-x   
2021 Szu JI, Obenaus A. Cerebrovascular phenotypes in mouse models of Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X21992462. PMID 33557692 DOI: 10.1177/0271678X21992462   
2021 Wu J, Shao C, Ye X, Di X, Li D, Zhao H, Zhang B, Chen G, Liu HK, Qian Y. Brain Imaging of Amyloid-β Aggregates in Alzheimer's Disease with a Near-Infrared Fluorescent Probe. Acs Sensors. PMID 33438997 DOI: 10.1021/acssensors.0c01914   
2021 James OG, Linares AR, Hellegers C, Doraiswamy PM, Wong TZ. Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series. Clinical Nuclear Medicine. PMID 33443955 DOI: 10.1097/RLU.0000000000003493   
2021 Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta Neuropathologica. PMID 33609158 DOI: 10.1007/s00401-021-02263-w   
2021 Rossi A, Galla L, Gomiero C, Zentilin L, Giacca M, Giorgio V, Calì T, Pozzan T, Greotti E, Pizzo P. Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease. Cells. 10. PMID 33494218 DOI: 10.3390/cells10020204   
2021 Seuma M, Faure A, Badia M, Lehner B, Bolognesi B. The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations. Elife. 10. PMID 33522485 DOI: 10.7554/eLife.63364   
2021 Chen Y, Zhao S, Fan Z, Li Z, Zhu Y, Shen T, Li K, Yan Y, Tian J, Liu Z, Zhang B. Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice. Alzheimer's Research & Therapy. 13: 40. PMID 33563332 DOI: 10.1186/s13195-020-00761-9   
2021 He P, Schulz P, Sierks MR. A conformation specific antibody against Oligomeric β-Amyloid Restores Neuronal Integrity in a Mouse Model of Alzheimer's Disease. The Journal of Biological Chemistry. 100241. PMID 33428939 DOI: 10.1074/jbc.RA120.015327   
2021 Garad M, Edelmann E, Leßmann V. Impairment of Spike-Timing-Dependent Plasticity at Schaffer Collateral-CA1 Synapses in Adult APP/PS1 Mice Depends on Proximity of Aβ Plaques. International Journal of Molecular Sciences. 22. PMID 33573114 DOI: 10.3390/ijms22031378   
2021 Devkota S, Williams TD, Wolfe MS. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of >45 residues. The Journal of Biological Chemistry. 100281. PMID 33450230 DOI: 10.1016/j.jbc.2021.100281   
2021 Syeda T, Cannon JR. Environmental exposures and the etiopathogenesis of Alzheimer's disease: The potential role of BACE1 as a critical neurotoxic target. Journal of Biochemical and Molecular Toxicology. e22694. PMID 33393683 DOI: 10.1002/jbt.22694   
2021 Bansal A, Schmidt M, Rennegarbe M, Haupt C, Liberta F, Stecher S, Puscalau-Girtu I, Biedermann A, Fändrich M. AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils. Nature Communications. 12: 1013. PMID 33579941 DOI: 10.1038/s41467-021-21129-z   
2021 Takahashi RH, Yokotsuka M, Tobiume M, Sato Y, Hasegawa H, Nagao T, Gouras GK. Accumulation of cellular prion protein within β-amyloid oligomer plaques in aged human brains. Brain Pathology (Zurich, Switzerland). e12941. PMID 33624334 DOI: 10.1111/bpa.12941   
2021 Yi S, Chen S, Xiang J, Tan J, Huang K, Zhang H, Wang Y, Wu H. Genistein exerts a cell-protective effect via Nrf2/HO-1/PI3K signaling in Aβ25-35-induced Alzheimer's disease models in vitro. Folia Histochemica Et Cytobiologica. PMID 33605427 DOI: 10.5603/FHC.a2021.0006   
2021 Nomoto D, Tsunoda T, Shigemori H. Effects of clovamide and its related compounds on the aggregations of amyloid polypeptides. Journal of Natural Medicines. PMID 33389592 DOI: 10.1007/s11418-020-01467-w   
2021 Sun Y, Liu Z, Pi Z, Song F, Wu J, Liu S. Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis. Phytotherapy Research : Ptr. PMID 33432644 DOI: 10.1002/ptr.7014   
2021 Shin J, Park S, Lee H, Kim Y. Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model. Scientific Reports. 11: 1617. PMID 33452414 DOI: 10.1038/s41598-021-81304-6