Bruce T. Lamb - Publications

Affiliations: 
1985-1991 Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
 1991-1994 Cellular/Molecular Biology Johns Hopkins University, Baltimore, MD 
 1996-2005 Genetics Case Western Reserve University, Cleveland Heights, OH, United States 
 2005-2016 Neurosciences The Cleveland Clinic, Cleveland, OH, United States 
 2016- Stark Neurosciences Research Institute Indiana University School of Medicine, Indianapolis, IN, United States 
Area:
Alzheimer's disease, traumatic brain injury, neurodegeneration, animal models, drug discovery
Website:
https://medicine.iu.edu/faculty/23627/lamb-bruce/

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Vitek MP, Araujo JA, Fossel M, Greenberg BD, Howell GR, Rizzo SJS, Seyfried NT, Tenner AJ, Territo PR, Windisch M, Bain LJ, Ross A, Carrillo MC, Lamb BT, Edelmayer RM. Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank. Alzheimer's & Dementia (New York, N. Y.). 6: e12114. PMID 33457489 DOI: 10.1002/trc2.12114  0.327
2020 Oblak AL, Forner S, Territo PR, Sasner M, Carter GW, Howell GR, Sukoff-Rizzo SJ, Logsdon BA, Mangravite LM, Mortazavi A, Baglietto-Vargas D, Green KN, MacGregor GR, Wood MA, Tenner AJ, ... ... Lamb BT, et al. Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD. Alzheimer's & Dementia (New York, N. Y.). 6: e12110. PMID 33283040 DOI: 10.1002/trc2.12110  0.342
2020 Preuss C, Pandey R, Piazza E, Fine A, Uyar A, Perumal T, Garceau D, Kotredes KP, Williams H, Mangravite LM, Lamb BT, Oblak AL, Howell GR, Sasner M, Logsdon BA, et al. A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease. Molecular Neurodegeneration. 15: 67. PMID 33172468 DOI: 10.1186/s13024-020-00412-5  0.319
2020 Jadhav VS, Lin PBC, Pennington T, Di Prisco GV, Jannu AJ, Xu G, Moutinho M, Zhang J, Atwood BK, Puntambekar SS, Bissel SJ, Oblak AL, Landreth GE, Lamb BT. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice. Molecular Neurodegeneration. 15: 62. PMID 33115519 DOI: 10.1186/s13024-020-00409-0  0.651
2019 Pillai JA, Maxwell S, Bena J, Bekris LM, Rao SM, Chance M, Lamb BT, Leverenz JB. Key inflammatory pathway activations in the MCI stage of Alzheimer's disease. Annals of Clinical and Translational Neurology. 6: 1248-1262. PMID 31353852 DOI: 10.1002/Acn3.50827  0.317
2019 Jay TR, von Saucken VE, Muñoz B, Codocedo JF, Atwood BK, Lamb BT, Landreth GE. TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment. Glia. PMID 31265185 DOI: 10.1002/Glia.23664  0.531
2019 Gunner G, Cheadle L, Johnson KM, Ayata P, Badimon A, Mondo E, Nagy MA, Liu L, Bemiller SM, Kim KW, Lira SA, Lamb BT, Tapper AR, Ransohoff RM, Greenberg ME, et al. Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling. Nature Neuroscience. PMID 31209379 DOI: 10.1038/S41593-019-0419-Y  0.35
2019 Mlodzianoski M, Cheng-Hathaway P, Liu S, Bemiller S, McCray T, Miller D, Lamb B, Landreth G, Huang F. Active PSF Shaping and Adaptive Optics Enable Volumetric Single Molecule Super-Resolution Microscopy through Brain Sections Biophysical Journal. 116: 283a-284a. DOI: 10.1016/J.Bpj.2018.11.1533  0.521
2018 Snyder HM, Carare RO, DeKosky ST, de Leon MJ, Dykxhoorn D, Gan L, Gardner R, Hinds SR, Jaffee M, Lamb BT, Landau S, Manley G, McKee A, Perl D, Schneider JA, et al. Military-related risk factors for dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30415806 DOI: 10.1016/J.Jalz.2018.08.011  0.388
2018 Kinney JW, Bemiller SM, Murtishaw AS, Leisgang AM, Salazar AM, Lamb BT. Inflammation as a central mechanism in Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 4: 575-590. PMID 30406177 DOI: 10.1016/J.Trci.2018.06.014  0.429
2018 Bemiller SM, Maphis NM, Formica SV, Wilson GN, Miller CM, Xu G, Kokiko-Cochran ON, Kim KW, Jung S, Cannon JL, Crish SD, Cardona AE, Lamb BT, Bhaskar K. Genetically enhancing the expression of chemokine domain of CXCL1 fails to prevent tau pathology in mouse models of tauopathy. Journal of Neuroinflammation. 15: 278. PMID 30253780 DOI: 10.1186/S12974-018-1310-6  0.735
2018 Sun K, Li X, Chen X, Bai Y, Zhou G, Kokiko-Cochran ON, Lamb B, Hamilton TA, Lin CY, Lee YS, Herjan T. Correction: Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease. Journal of Immunology (Baltimore, Md. : 1950). PMID 30037850 DOI: 10.4049/Jimmunol.1800930  0.726
2018 Mlodzianoski MJ, Cheng-Hathaway PJ, Bemiller SM, McCray TJ, Liu S, Miller DA, Lamb BT, Landreth GE, Huang F. Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections. Nature Methods. PMID 30013047 DOI: 10.1038/S41592-018-0053-8  0.575
2018 Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, von Saucken VE, Williams RY, Karlo JC, Moutinho M, Xu G, Ransohoff RM, Lamb BT, Landreth GE. The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease. Molecular Neurodegeneration. 13: 29. PMID 29859094 DOI: 10.1186/S13024-018-0262-8  0.663
2018 Sun K, Li X, Chen X, Bai Y, Zhou G, Kokiko-Cochran ON, Lamb B, Hamilton TA, Lin CY, Lee YS, Herjan T. Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease. Journal of Immunology (Baltimore, Md. : 1950). PMID 29760195 DOI: 10.4049/jimmunol.1701501  0.736
2018 Puntambekar SS, Saber M, Lamb BT, Kokiko-Cochran ON. Cellular Players that Shape Evolving Pathology and Neurodegeneration Following Traumatic Brain Injury. Brain, Behavior, and Immunity. PMID 29601944 DOI: 10.1016/J.Bbi.2018.03.033  0.77
2018 Katsumoto A, Miranda AS, Butovsky O, Teixeira AL, Ransohoff RM, Lamb BT. Laquinimod attenuates inflammation by modulating macrophage functions in traumatic brain injury mouse model. Journal of Neuroinflammation. 15: 26. PMID 29382353 DOI: 10.1186/S12974-018-1075-Y  0.354
2018 Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV, ... ... Lamb BT, et al. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model. Brain : a Journal of Neurology. PMID 29360998 DOI: 10.1093/Brain/Awx350  0.718
2018 Achebe N, Puntambekar, Ph.D SS, Lamb BT. A TREM2 dependent control of Microglial and Astrocytic responses in a mouse model of Alzheimer's Disease Proceedings of Imprs. 1. DOI: 10.18060/22648  0.464
2017 Bemiller SM, McCray TJ, Allan K, Formica SV, Xu G, Wilson G, Kokiko-Cochran ON, Crish SD, Lasagna-Reeves CA, Ransohoff RM, Landreth GE, Lamb BT. TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy. Molecular Neurodegeneration. 12: 74. PMID 29037207 DOI: 10.1186/S13024-017-0216-6  0.816
2017 Kokiko-Cochran ON, Saber M, Puntambekar S, Bemiller SM, Katsumoto A, Lee YS, Bhaskar K, Ransohoff RM, Lamb BT. Traumatic brain injury in hTau model mice: Enhanced acute macrophage response and altered long-term recovery. Journal of Neurotrauma. PMID 28859549 DOI: 10.1089/Neu.2017.5203  0.741
2017 Maphis NM, Jiang S, Binder J, Wright C, Gopalan B, Lamb BT, Bhaskar K. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Frontiers in Molecular Neuroscience. 10: 69. PMID 28367114 DOI: 10.3389/Fnmol.2017.00069  0.496
2017 Jay TR, Hirsch AM, Broihier ML, Miller CM, Neilson LE, Ransohoff RM, Lamb BT, Landreth GE. Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 637-647. PMID 28100745 DOI: 10.1523/Jneurosci.2110-16.2016  0.702
2017 Sasner M, Carter GW, Howell G, Rizzo SJ, Williams HM, Preuss C, Wang X, Philip V, Ananda G, Uyar A, Onos K, Logsdon B, Omberg L, Mangravite LM, Lamb BT, et al. [P4-060]: MODEL ORGANISM DEVELOPMENT AND EVALUATION FOR LATE-ONSET ALZHEIMER's DISEASE: MODEL-AD Alzheimer's & Dementia. 13: P1280-P1281. DOI: 10.1016/J.Jalz.2017.06.1925  0.422
2016 Maphis N, Jiang S, Xu G, Kokiko-Cochran ON, Roy SM, Van Eldik LJ, Watterson DM, Lamb BT, Bhaskar K. Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology. Alzheimer's Research & Therapy. 8: 54. PMID 27974048 DOI: 10.1186/S13195-016-0221-Y  0.755
2016 Jay TR, Hirsch AM, Broihier ML, Miller CM, Neilson LE, Ransohoff RM, Lamb BT, Landreth GE. Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27940990 DOI: 10.1523/JNEUROSCI.2110-16.2016  0.67
2016 Heneka M, Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, et al. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of Neurochemistry. PMID 27248001 DOI: 10.1111/Jnc.13667  0.624
2016 Saber M, Kokiko-Cochran O, Puntambekar SS, Lathia JD, Lamb BT. Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury. Journal of Neurotrauma. PMID 26976047 DOI: 10.1089/Neu.2016.4401  0.762
2016 Provencio JJ, Swank V, Lu H, Brunet S, Baltan S, Khapre RV, Seerapu H, Kokiko-Cochran ON, Lamb BT, Ransohoff RM. Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors. Brain, Behavior, and Immunity. PMID 26872422 DOI: 10.1016/J.Bbi.2016.02.007  0.693
2016 Cheng-Hathaway P, Jay T, Reed E, Bemiller S, Puntambekar S, Xu G, Carlo C, Ransohoff R, Landreth G, Lamb BT. 02-07-06: The R47H Trem2 Variant Modifies Alzheimer's Disease Pathology and Neuroinflammation in a Novel Knock-In Mouse Model Alzheimer's & Dementia. 12: P243-P243. DOI: 10.1016/J.Jalz.2016.06.435  0.617
2016 Lamb BT. EC-02-02: Trem2 Clearance of Amyloid: Peripheral vs. Cns-Derived Cells Alzheimer's & Dementia. 12: P213-P214. DOI: 10.1016/J.Jalz.2016.06.2368  0.392
2015 Gyoneva S, Kim D, Katsumoto A, Kokiko-Cochran ON, Lamb BT, Ransohoff RM. Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury. Journal of Neuroinflammation. 12: 228. PMID 26634348 DOI: 10.1186/S12974-015-0443-0  0.468
2015 Jay T, Lamb B, Landreth G. Peripheral macrophages not ADept at amyloid clearance. The Journal of Experimental Medicine. 212: 1758. PMID 26482143 DOI: 10.1084/jem.21211insight5  0.574
2015 Kokiko-Cochran ON, Ransohoff L, Veenstra M, Lee S, Saber M, Sikora M, Teknipp R, Xu G, Bemiller S, Wilson G, Crish S, Bhaskar K, Lee YS, Ransohoff RM, Lamb BT. Altered neuroinflammation and behavior following traumatic brain injury in a mouse model of Alzheimer's disease. Journal of Neurotrauma. PMID 26414955 DOI: 10.1089/Neu.2015.3970  0.775
2015 Maphis N, Xu G, Kokiko-Cochran ON, Cardona AE, Ransohoff RM, Lamb BT, Bhaskar K. Loss of tau rescues inflammation-mediated neurodegeneration. Frontiers in Neuroscience. 9: 196. PMID 26089772 DOI: 10.3389/Fnins.2015.00196  0.794
2015 Savage JC, Jay T, Goduni E, Quigley C, Mariani MM, Malm T, Ransohoff RM, Lamb BT, Landreth GE. Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6532-43. PMID 25904803 DOI: 10.1523/Jneurosci.4586-14.2015  0.67
2015 Komuro Y, Xu G, Bhaskar K, Lamb BT. Human tau expression reduces adult neurogenesis in a mouse model of tauopathy. Neurobiology of Aging. 36: 2034-42. PMID 25863528 DOI: 10.1016/J.Neurobiolaging.2015.03.002  0.643
2015 Maphis N, Xu G, Kokiko-Cochran ON, Jiang S, Cardona A, Ransohoff RM, Lamb BT, Bhaskar K. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain : a Journal of Neurology. 138: 1738-55. PMID 25833819 DOI: 10.1093/Brain/Awv081  0.783
2015 Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, ... ... Lamb BT, et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. The Journal of Experimental Medicine. 212: 287-95. PMID 25732305 DOI: 10.1084/Jem.20142322  0.712
2015 Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, et al. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 710-717. PMID 25510382 DOI: 10.1016/J.Jalz.2014.10.008  0.367
2014 Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, ... ... Lamb B, et al. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S430-52. PMID 25341459 DOI: 10.1016/J.Jalz.2014.08.103  0.59
2014 Lee S, Xu G, Jay TR, Bhatta S, Kim KW, Jung S, Landreth GE, Ransohoff RM, Lamb BT. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12538-46. PMID 25209291 DOI: 10.1523/Jneurosci.0853-14.2014  0.68
2014 Bhaskar K, Maphis N, Xu G, Varvel NH, Kokiko-Cochran ON, Weick JP, Staugaitis SM, Cardona A, Ransohoff RM, Herrup K, Lamb BT. Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events. Neurobiology of Disease. 62: 273-85. PMID 24141019 DOI: 10.1016/J.Nbd.2013.10.007  0.804
2014 Lamb B, Miller C, Jay T, Graham L, Bemiller S, Xu G, Margevicius D, Karlo C, Sousa G, Cotleur B, Bekris L, Staugaitis S, Leverenz J, Pimplikar SW, Landreth G, et al. P4-248: THE ROLE OF TREM2 EXPRESSION ON MYELOID CELLS IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P876-P877. DOI: 10.1016/J.Jalz.2014.07.019  0.622
2014 Baltan S, Bhatta S, Bastian C, Brunet S, Lamb B. P3-048: IMPAIRED SYNAPTIC PLASTICITY PRECEDES TAU AGGREGATION IN HTAU MOUSE MODEL OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P646-P646. DOI: 10.1016/J.Jalz.2014.05.1135  0.432
2014 Bhaskar K, Maphis N, Kang Z, Li X, Lamb BT. 10 Cytokine. 70: 30. DOI: 10.1016/J.Cyto.2014.07.017  0.466
2013 Ogolla PS, Portillo JA, White CL, Patel K, Lamb B, Sen GC, Subauste CS. The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen. Plos Pathogens. 9: e1003557. PMID 23990781 DOI: 10.1371/Journal.Ppat.1003557  0.308
2013 Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, et al. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 189-98. PMID 23062850 DOI: 10.1016/J.Jalz.2012.03.003  0.34
2013 Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, et al. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 176-88. PMID 23043900 DOI: 10.1016/J.Jalz.2012.03.002  0.377
2013 Lamb B, Lee S, Xu G, Ransohoff R. O2-01-04: Inflammatory pathways link amyloid and tau pathology Alzheimer's & Dementia. 9: P315-P315. DOI: 10.1016/J.Jalz.2013.04.138  0.39
2012 Cameron B, Tse W, Lamb R, Li X, Lamb BT, Landreth GE. Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15112-23. PMID 23100432 DOI: 10.1523/Jneurosci.1729-12.2012  0.69
2012 Vidal R, Sammeta N, Garringer HJ, Sambamurti K, Miravalle L, Lamb BT, Ghetti B. The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2899-910. PMID 22459153 DOI: 10.1096/Fj.12-205542  0.498
2012 Hamaguchi T, Eisele YS, Varvel NH, Lamb BT, Walker LC, Jucker M. The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain. Acta Neuropathologica. 123: 31-7. PMID 22101366 DOI: 10.1007/S00401-011-0912-1  0.8
2012 Wilkinson BL, Cramer PE, Varvel NH, Reed-Geaghan E, Jiang Q, Szabo A, Herrup K, Lamb BT, Landreth GE. Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiology of Aging. 33: 197.e21-32. PMID 20696495 DOI: 10.1016/J.Neurobiolaging.2010.06.014  0.801
2012 Lamb B. The roles of fractalkine signaling in neurodegenerative disease Molecular Neurodegeneration. 7: L21. DOI: 10.1186/1750-1326-7-S1-L21  0.569
2012 Ghetti B, Vidal R, Sammeta N, Garringer H, Sambamurti K, Miravalle L, Lamb B. The Psen1-L166P knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice Alzheimers & Dementia. 8: 86. DOI: 10.1016/J.Jalz.2012.05.209  0.433
2012 Bhaskar K, Maphis N, Varvel N, Kokiko-Cochran O, Ransohoff R, Herrup K, Lamb B. P161 Cell-autonomous effect of microglia on the induction of Alzheimer’s disease neuronal cell cycle events Cytokine. 59: 571. DOI: 10.1016/J.Cyto.2012.06.262  0.821
2011 Golde TE, Lamb BT, Galasko D. Right sizing funding for Alzheimer's disease. Alzheimer's Research & Therapy. 3: 17. PMID 21554753 DOI: 10.1186/Alzrt76  0.395
2011 Vogt DL, Thomas D, Galvan V, Bredesen DE, Lamb BT, Pimplikar SW. Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain Neurobiology of Aging. 32: 1725-1729. PMID 19828212 DOI: 10.1016/J.Neurobiolaging.2009.09.002  0.443
2011 Lamb B. The opposing roles of neuronal-microglial communication in Alzheimer's disease F1000research. 2. DOI: 10.7490/F1000Research.2023.1  0.427
2011 Lamb B. F2-03-06: The Opposing Roles of Neuronal-Microglial Communication in Alzheimer's Disease Alzheimer's & Dementia. 7: S287-S287. DOI: 10.1016/J.Jalz.2011.05.827  0.393
2010 Bhaskar K, Konerth M, Kokiko-Cochran ON, Cardona A, Ransohoff RM, Lamb BT. Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 68: 19-31. PMID 20920788 DOI: 10.1016/J.Neuron.2010.08.023  0.75
2010 Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, Lamb BT. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. The American Journal of Pathology. 177: 2549-62. PMID 20864679 DOI: 10.2353/Ajpath.2010.100265  0.816
2010 Edwards MM, Marín de Evsikova C, Collin GB, Gifford E, Wu J, Hicks WL, Whiting C, Varvel NH, Maphis N, Lamb BT, Naggert JK, Nishina PM, Peachey NS. Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2. Investigative Ophthalmology & Visual Science. 51: 3264-72. PMID 20071672 DOI: 10.1167/Iovs.09-4887  0.731
2010 Lamb BT, Bhaskar K, Lee S, Varvel NH, Konerth ME, Kokiko-Cochran ON, Cardona AE, Ransohoff RM. S4-03-04: The Opposing Roles of Fractalkine Signaling in Alzheimer's Disease Pathogenesis Alzheimer's & Dementia. 6: e14-e14. DOI: 10.1016/J.Jalz.2010.08.043  0.758
2010 Eisele YS, Hamaguchi T, Obermueller U, Heilbronner G, Langer F, Lamb B, Staufenbiel M, Heikenwalder M, Jucker M. Various inoculation routes of Aβ-containing brain extract in APP-tg mice Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.731  0.442
2009 Hock BJ, Lattal KM, Kulnane LS, Abel T, Lamb BT. Pathology associated memory deficits in Swedish mutant genome-based amyloid precursor protein transgenic mice. Current Aging Science. 2: 205-13. PMID 20021415 DOI: 10.2174/1874609810902030205  0.483
2009 Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, Herrup K. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 119: 3692-702. PMID 19907078 DOI: 10.1172/Jci39716  0.84
2009 Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW. Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain. Proceedings of the National Academy of Sciences of the United States of America. 106: 18367-72. PMID 19837693 DOI: 10.1073/Pnas.0907652106  0.547
2009 Aliev G, Palacios HH, Lipsitt AE, Fischbach K, Lamb BT, Obrenovich ME, Morales L, Gasimov E, Bragin V. Nitric oxide as an initiator of brain lesions during the development of Alzheimer disease. Neurotoxicity Research. 16: 293-305. PMID 19526276 DOI: 10.1007/S12640-009-9066-5  0.331
2009 Atwood C, Brewer G, Herrup K, Kim D, Khurana V, Lamb B, Langley B, Leitner M, Muresan V, Neve R, Park K, Patzke H, Strobel G, Tsai LH, Yankner B. Alzheimer research forum live discussion: Meet new players, histone deacetylase and sirtuin - Will they help the cell cycle, DNA repair, and gene expression break into alzheimerology's major league? Journal of Alzheimer's Disease. 17: 233-238. PMID 19433902 DOI: 10.3233/Jad-2009-1084  0.542
2009 Muresan V, Varvel NH, Lamb BT, Muresan Z. The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3565-78. PMID 19295161 DOI: 10.1523/Jneurosci.2558-08.2009  0.762
2009 Bhaskar K, Miller M, Chludzinski A, Herrup K, Zagorski M, Lamb BT. The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Molecular Neurodegeneration. 4: 14. PMID 19291319 DOI: 10.1186/1750-1326-4-14  0.667
2008 Varvel NH, Bhaskar K, Patil AR, Pimplikar SW, Herrup K, Lamb BT. Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10786-93. PMID 18945886 DOI: 10.1523/Jneurosci.2441-08.2008  0.832
2008 Tan J, Mao G, Cui MZ, Kang SC, Lamb B, Wong BS, Sy MS, Xu X. Effects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical model. Journal of Neurochemistry. 107: 722-33. PMID 18752644 DOI: 10.1111/J.1471-4159.2008.05643.X  0.412
2008 Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, et al. ApoE promotes the proteolytic degradation of Abeta. Neuron. 58: 681-93. PMID 18549781 DOI: 10.1016/J.Neuron.2008.04.010  0.771
2008 Ryman D, Gao Y, Lamb BT. Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease Neurobiology of Aging. 29: 1190-1198. PMID 17400334 DOI: 10.1016/J.Neurobiolaging.2007.02.017  0.494
2007 Chiocco MJ, Lamb BT. Spatial and temporal control of age-related APP processing in genomic-based beta-secretase transgenic mice. Neurobiology of Aging. 28: 75-84. PMID 16387391 DOI: 10.1016/J.Neurobiolaging.2005.11.011  0.817
2006 Ryman D, Lamb BT. Genetic and environmental modifiers of Alzheimer's disease phenotypes in the mouse. Current Alzheimer Research. 3: 465-73. PMID 17168645 DOI: 10.2174/156720506779025198  0.463
2006 Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, ... Lamb BT, et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 51: 29-42. PMID 16815330 DOI: 10.1016/J.Neuron.2006.05.022  0.326
2006 Yang Y, Varvel NH, Lamb BT, Herrup K. Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 775-84. PMID 16421297 DOI: 10.1523/Jneurosci.3707-05.2006  0.827
2006 Lamb BT. S2-02-01: NEW IN VIVO MODELS FOR ALZHEIMER'S DISEASE: MODEL-AD Alzheimer's & Dementia. 14: P601-P601. DOI: 10.1016/j.jalz.2018.06.2606  0.329
2006 Lamb BT, Oblak AL, Williams HM, Baglietto-Vargas D, Wood MA, Mortazavi A, Green KN, Carter GW, Sukoff Rizzo SJ, Territo P, Sasner M, Macgregor GR, Tenner A, LaFerla F, Howell G. P1-131: MODEL-AD: LATE-ONSET ALZHEIMER'S DISEASE MODELS Alzheimer's & Dementia. 14: P321-P321. DOI: 10.1016/J.Jalz.2018.06.134  0.336
2006 Lamb BT, Ryman DC, Schrump S, Varvel N. P1-123: Modifiers of Alzheimer's disease phenotypes in the mouse Alzheimer's & Dementia. 2: S131-S132. DOI: 10.1016/j.jalz.2006.05.499  0.759
2005 Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL. Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897. Biochemical Pharmacology. 69: 689-98. PMID 15670587 DOI: 10.1016/j.bcp.2004.11.015  0.345
2004 Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT. Altered amyloid-β metabolism and deposition in genomic-based β-secretaee transgenic mice Journal of Biological Chemistry. 279: 52535-52542. PMID 15452128 DOI: 10.1074/Jbc.M409680200  0.819
2004 Yu WH, Kumar A, Peterhoff C, Shapiro Kulnane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. The International Journal of Biochemistry & Cell Biology. 36: 2531-40. PMID 15325590 DOI: 10.1016/J.Biocel.2004.05.010  0.331
2004 Aliyev A, Seyidova D, Rzayev N, Obrenovich ME, Lamb BT, Chen SG, Smith MA, Perry G, de la Torre JC, Aliev G. Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease? Neurological Research. 26: 547-53. PMID 15265272 DOI: 10.1179/01610425017613  0.312
2004 Mann KM, Thorngate FE, Katoh-Fukui Y, Hamanaka H, Williams DL, Fujita S, Lamb BT. Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model. Human Molecular Genetics. 13: 1959-68. PMID 15229191 DOI: 10.1093/Hmg/Ddh199  0.704
2004 Harris-Cerruti C, Kamsler A, Kaplan B, Lamb B, Segal M, Groner Y. Functional and morphological alterations in compound transgenic mice overexpressing Cu/Zn superoxide dismutase and amyloid precursor protein [correction]. The European Journal of Neuroscience. 19: 1174-90. PMID 15016076 DOI: 10.1111/J.1460-9568.2004.03188.X  0.338
2004 Lamb BT, Ryman DC, Gao Y, Kulnane LS. P2-117 Genetics modifiers of beta-amyloid metabolism and deposition in the mouse Neurobiology of Aging. 25: S258. DOI: 10.1016/S0197-4580(04)80864-9  0.35
2004 Nixon RA, Yu WH, Cuervo AM, Cataldo AM, Mathews PM, Yang D, Zheng P, Peterhoff CM, Kumar A, Jiang Y, Peterson J, Schmidt SD, Mohan P, Duff K, Hassinger L, ... ... Lamb B, et al. S4-03-04 Autophagy in Alzheimer's disease pathogenesis Neurobiology of Aging. 25: S70-S71. DOI: 10.1016/S0197-4580(04)80240-9  0.403
2003 Lehman EJ, Kulnane LS, Gao Y, Petriello MC, Pimpis KM, Younkin L, Dolios G, Wang R, Younkin SG, Lamb BT. Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. Human Molecular Genetics. 12: 2949-56. PMID 14506131 DOI: 10.1093/Hmg/Ddg322  0.314
2003 Aliev G, Seyidova D, Lamb BT, Obrenovich ME, Siedlak SL, Vinters HV, Friedland RP, LaManna JC, Smith MA, Perry G. Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice. Neurological Research. 25: 665-74. PMID 14503022 DOI: 10.1179/016164103101201977  0.403
2003 Lehman EJ, Kulnane LS, Lamb BT. Alterations in beta-amyloid production and deposition in brain regions of two transgenic models. Neurobiology of Aging. 24: 645-53. PMID 12885572  0.387
2002 Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Annals of the New York Academy of Sciences. 977: 45-64. PMID 12480733 DOI: 10.1111/J.1749-6632.2002.Tb04798.X  0.343
2002 Kulnane LS, Lamb BT. Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice. Neurobiology of Disease. 8: 982-92. PMID 11741394 DOI: 10.1006/nbdi.2001.0446  0.418
2001 Hock BJ, Lamb BT. Transgenic mouse models of Alzheimer's disease. Trends in Genetics : Tig. 17: S7-12. PMID 11585670 DOI: 10.1016/S0168-9525(01)02449-0  0.334
2000 Lamb BT, Kulnane LS, Hock BJ, Lattal K. Neuropathological and behavioral characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice Neurobiology of Aging. 21: 224. DOI: 10.1016/S0197-4580(00)83339-4  0.382
2000 Aliev G, Shi J, LaManna JC, Lamb BT, Friedland RP. Atherosclerotic-like changes of the wall of cerebral microvessels in transgenic mice overexpressing amyloid β Neurobiology of Aging. 21: 267. DOI: 10.1016/S0197-4580(00)83155-3  0.388
2000 Aliev G, Shi J, LaManna JC, Friedland RP, Lamb BT. Mitochondrial abnormalities mark vulnerable neurons in APP YAC transgenic mice Neurobiology of Aging. 21: 267. DOI: 10.1016/S0197-4580(00)83153-X  0.397
1997 Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, Younkin SG, Holtz G, Wagner SL, Price DL, Sisodia SS, Gearhart JD. Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Human Molecular Genetics. 6: 1535-41. PMID 9285791 DOI: 10.1093/Hmg/6.9.1535  0.341
1997 Lamb BT. Presenilins, amyloid-beta and Alzheimer's disease. Nature Medicine. 3: 28-9. PMID 8986735 DOI: 10.1038/NM0197-28  0.331
1993 Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nature Genetics. 5: 22-30. PMID 8220418 DOI: 10.1038/Ng0993-22  0.377
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