Bruce T. Lamb - Publications

Affiliations: 
1985-1991 Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
 1991-1994 Cellular/Molecular Biology Johns Hopkins University, Baltimore, MD 
 1996-2005 Case Western Reserve University, Cleveland Heights, OH, United States 
 2005-2016 Neurosciences The Cleveland Clinic, Cleveland, OH, United States 
 2016- Purdue University, West Lafayette, IN, United States 

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Bemiller SM, Maphis NM, Formica SV, Wilson GN, Miller CM, Xu G, Kokiko-Cochran ON, Kim KW, Jung S, Cannon JL, Crish SD, Cardona AE, Lamb BT, Bhaskar K. Genetically enhancing the expression of chemokine domain of CXCL1 fails to prevent tau pathology in mouse models of tauopathy. Journal of Neuroinflammation. 15: 278. PMID 30253780 DOI: 10.1186/s12974-018-1310-6  0.48
2018 Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, von Saucken VE, Williams RY, Karlo JC, Moutinho M, Xu G, Ransohoff RM, Lamb BT, Landreth GE. The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease. Molecular Neurodegeneration. 13: 29. PMID 29859094 DOI: 10.1186/s13024-018-0262-8  0.48
2017 Bemiller SM, McCray TJ, Allan K, Formica SV, Xu G, Wilson G, Kokiko-Cochran ON, Crish SD, Lasagna-Reeves CA, Ransohoff RM, Landreth GE, Lamb BT. TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy. Molecular Neurodegeneration. 12: 74. PMID 29037207 DOI: 10.1186/s13024-017-0216-6  0.48
2017 Kokiko-Cochran ON, Saber M, Puntambekar S, Bemiller SM, Katsumoto A, Lee YS, Bhaskar K, Ransohoff RM, Lamb BT. Traumatic brain injury in hTau model mice: Enhanced acute macrophage response and altered long-term recovery. Journal of Neurotrauma. PMID 28859549 DOI: 10.1089/neu.2017.5203  0.48
2017 Maphis NM, Jiang S, Binder J, Wright C, Gopalan B, Lamb BT, Bhaskar K. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Frontiers in Molecular Neuroscience. 10: 69. PMID 28367114 DOI: 10.3389/fnmol.2017.00069  0.48
2016 Maphis N, Jiang S, Xu G, Kokiko-Cochran ON, Roy SM, Van Eldik LJ, Watterson DM, Lamb BT, Bhaskar K. Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology. Alzheimer's Research & Therapy. 8: 54. PMID 27974048 DOI: 10.1186/s13195-016-0221-y  0.48
2015 Gyoneva S, Kim D, Katsumoto A, Kokiko-Cochran ON, Lamb BT, Ransohoff RM. Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury. Journal of Neuroinflammation. 12: 228. PMID 26634348 DOI: 10.1186/s12974-015-0443-0  0.48
2015 Kokiko-Cochran ON, Ransohoff L, Veenstra M, Lee S, Saber M, Sikora M, Teknipp R, Xu G, Bemiller S, Wilson G, Crish S, Bhaskar K, Lee YS, Ransohoff RM, Lamb BT. Altered neuroinflammation and behavior following traumatic brain injury in a mouse model of Alzheimer's disease. Journal of Neurotrauma. PMID 26414955 DOI: 10.1089/neu.2015.3970  0.48
2015 Maphis N, Xu G, Kokiko-Cochran ON, Cardona AE, Ransohoff RM, Lamb BT, Bhaskar K. Loss of tau rescues inflammation-mediated neurodegeneration. Frontiers in Neuroscience. 9: 196. PMID 26089772 DOI: 10.3389/fnins.2015.00196  0.48
2015 Savage JC, Jay T, Goduni E, Quigley C, Mariani MM, Malm T, Ransohoff RM, Lamb BT, Landreth GE. Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6532-43. PMID 25904803 DOI: 10.1523/JNEUROSCI.4586-14.2015  0.48
2015 Komuro Y, Xu G, Bhaskar K, Lamb BT. Human tau expression reduces adult neurogenesis in a mouse model of tauopathy. Neurobiology of Aging. 36: 2034-42. PMID 25863528 DOI: 10.1016/j.neurobiolaging.2015.03.002  0.48
2015 Maphis N, Xu G, Kokiko-Cochran ON, Jiang S, Cardona A, Ransohoff RM, Lamb BT, Bhaskar K. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain : a Journal of Neurology. 138: 1738-55. PMID 25833819 DOI: 10.1093/brain/awv081  0.48
2015 Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, ... ... Lamb BT, et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. The Journal of Experimental Medicine. 212: 287-95. PMID 25732305 DOI: 10.1084/jem.20142322  0.48
2015 Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, et al. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 710-717. PMID 25510382 DOI: 10.1016/j.jalz.2014.10.008  0.48
2014 Lee S, Xu G, Jay TR, Bhatta S, Kim KW, Jung S, Landreth GE, Ransohoff RM, Lamb BT. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12538-46. PMID 25209291 DOI: 10.1523/JNEUROSCI.0853-14.2014  0.48
2014 Bhaskar K, Maphis N, Xu G, Varvel NH, Kokiko-Cochran ON, Weick JP, Staugaitis SM, Cardona A, Ransohoff RM, Herrup K, Lamb BT. Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events. Neurobiology of Disease. 62: 273-85. PMID 24141019 DOI: 10.1016/j.nbd.2013.10.007  0.48
2012 Hamaguchi T, Eisele YS, Varvel NH, Lamb BT, Walker LC, Jucker M. The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain. Acta Neuropathologica. 123: 31-7. PMID 22101366 DOI: 10.1007/s00401-011-0912-1  0.48
2012 Wilkinson BL, Cramer PE, Varvel NH, Reed-Geaghan E, Jiang Q, Szabo A, Herrup K, Lamb BT, Landreth GE. Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiology of Aging. 33: 197.e21-32. PMID 20696495 DOI: 10.1016/j.neurobiolaging.2010.06.014  0.48
2011 Golde TE, Lamb BT, Galasko D. Right sizing funding for Alzheimer's disease. Alzheimer's Research & Therapy. 3: 17. PMID 21554753 DOI: 10.1186/alzrt76  0.48
2010 Bhaskar K, Konerth M, Kokiko-Cochran ON, Cardona A, Ransohoff RM, Lamb BT. Regulation of tau pathology by the microglial fractalkine receptor. Neuron. 68: 19-31. PMID 20920788 DOI: 10.1016/j.neuron.2010.08.023  0.48
2010 Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, Lamb BT. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. The American Journal of Pathology. 177: 2549-62. PMID 20864679 DOI: 10.2353/ajpath.2010.100265  0.48
2010 Edwards MM, Marín de Evsikova C, Collin GB, Gifford E, Wu J, Hicks WL, Whiting C, Varvel NH, Maphis N, Lamb BT, Naggert JK, Nishina PM, Peachey NS. Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2. Investigative Ophthalmology & Visual Science. 51: 3264-72. PMID 20071672 DOI: 10.1167/iovs.09-4887  0.48
2009 Hock BJ, Lattal KM, Kulnane LS, Abel T, Lamb BT. Pathology associated memory deficits in Swedish mutant genome-based amyloid precursor protein transgenic mice. Current Aging Science. 2: 205-13. PMID 20021415 DOI: 10.2174/1874609810902030205  0.48
2009 Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, Herrup K. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 119: 3692-702. PMID 19907078 DOI: 10.1172/JCI39716  0.48
2009 Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW. Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain. Proceedings of the National Academy of Sciences of the United States of America. 106: 18367-72. PMID 19837693 DOI: 10.1073/pnas.0907652106  0.48
2009 Aliev G, Palacios HH, Lipsitt AE, Fischbach K, Lamb BT, Obrenovich ME, Morales L, Gasimov E, Bragin V. Nitric oxide as an initiator of brain lesions during the development of Alzheimer disease. Neurotoxicity Research. 16: 293-305. PMID 19526276 DOI: 10.1007/s12640-009-9066-5  0.48
2009 Muresan V, Varvel NH, Lamb BT, Muresan Z. The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3565-78. PMID 19295161 DOI: 10.1523/JNEUROSCI.2558-08.2009  0.48
2009 Bhaskar K, Miller M, Chludzinski A, Herrup K, Zagorski M, Lamb BT. The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Molecular Neurodegeneration. 4: 14. PMID 19291319 DOI: 10.1186/1750-1326-4-14  0.48
2008 Varvel NH, Bhaskar K, Patil AR, Pimplikar SW, Herrup K, Lamb BT. Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10786-93. PMID 18945886 DOI: 10.1523/JNEUROSCI.2441-08.2008  0.48
2008 Ryman D, Gao Y, Lamb BT. Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease Neurobiology of Aging. 29: 1190-1198. PMID 17400334 DOI: 10.1016/j.neurobiolaging.2007.02.017  0.48
2007 Chiocco MJ, Lamb BT. Spatial and temporal control of age-related APP processing in genomic-based beta-secretase transgenic mice. Neurobiology of Aging. 28: 75-84. PMID 16387391 DOI: 10.1016/j.neurobiolaging.2005.11.011  0.68
2006 Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, ... Lamb BT, et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 51: 29-42. PMID 16815330 DOI: 10.1016/j.neuron.2006.05.022  0.48
2006 Yang Y, Varvel NH, Lamb BT, Herrup K. Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 775-84. PMID 16421297 DOI: 10.1523/JNEUROSCI.3707-05.2006  0.48
2005 Youngren KK, Coveney D, Peng X, Bhattacharya C, Schmidt LS, Nickerson ML, Lamb BT, Deng JM, Behringer RR, Capel B, Rubin EM, Nadeau JH, Matin A. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature. 435: 360-4. PMID 15902260 DOI: 10.1038/nature03595  0.48
2004 Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT. Altered amyloid-β metabolism and deposition in genomic-based β-secretaee transgenic mice Journal of Biological Chemistry. 279: 52535-52542. PMID 15452128 DOI: 10.1074/jbc.M409680200  0.48
2004 Seyidova D, Aliyev A, Rzayev N, Obrenovich M, Lamb BT, Smith MA, de la Torre JC, Perry G, Aliev G. The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease. In Vivo (Athens, Greece). 18: 325-33. PMID 15341188  0.48
2004 Aliyev A, Seyidova D, Rzayev N, Obrenovich ME, Lamb BT, Chen SG, Smith MA, Perry G, de la Torre JC, Aliev G. Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease? Neurological Research. 26: 547-53. PMID 15265272 DOI: 10.1179/01610425017613  0.48
2003 Lehman EJ, Kulnane LS, Gao Y, Petriello MC, Pimpis KM, Younkin L, Dolios G, Wang R, Younkin SG, Lamb BT. Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. Human Molecular Genetics. 12: 2949-56. PMID 14506131 DOI: 10.1093/hmg/ddg322  0.48
2003 Aliev G, Seyidova D, Lamb BT, Obrenovich ME, Siedlak SL, Vinters HV, Friedland RP, LaManna JC, Smith MA, Perry G. Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice. Neurological Research. 25: 665-74. PMID 14503022 DOI: 10.1179/016164103101201977  0.48
2002 Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Annals of the New York Academy of Sciences. 977: 45-64. PMID 12480733  0.48
2002 Kulnane LS, Lehman EJ, Hock BJ, Tsuchiya KD, Lamb BT. Rapid and efficient detection of transgene homozygosity by FISH of mouse fibroblasts. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 13: 223-6. PMID 11956767 DOI: 10.1007/s00335-001-2128-5  0.48
2002 Aliev G, Smith MA, Seyidov D, Neal ML, Lamb BT, Nunomura A, Gasimov EK, Vinters HV, Perry G, LaManna JC, Friedland RP. The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease. Brain Pathology (Zurich, Switzerland). 12: 21-35. PMID 11770899  0.48
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