Patrick C. Bradshaw, PhD - Publications

Affiliations: 
2015- Department of Biomedical Sciences East Tennessee State University - Quillen School of Medicine 
Area:
mitochondrial function, aging, neurodegeneration
Website:
http://www.etsu.edu/com/dbms/faculty/bios/bradshaw.aspx

32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Curtis WM, Seeds WA, Mattson MP, Bradshaw PC. NADPH and Mitochondrial Quality Control as Targets for a Circadian-Based Fasting and Exercise Therapy for the Treatment of Parkinson's Disease. Cells. 11. PMID 35954260 DOI: 10.3390/cells11152416  0.4
2019 Bradshaw PC. Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging. Nutrients. 11. PMID 30818813 DOI: 10.3390/nu11030504  0.419
2018 Delic V, Noble K, Zivkovic S, Phan TA, Reynes C, Zhang Y, Phillips O, Claybaker C, Ta Y, Dinh VB, Cruz J, Prolla TA, Bradshaw PC. The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts. Biology Open. PMID 30177551 DOI: 10.1242/Bio.033852  0.813
2018 Delic V, Kurien C, Cruz J, Zivkovic S, Barretta J, Thomson A, Hennessey D, Joseph J, Ehrhart J, Willing AE, Bradshaw P, Garbuzova-Davis S. Discrete mitochondrial aberrations in the spinal cord of sporadic ALS patients. Journal of Neuroscience Research. PMID 29732581 DOI: 10.1002/Jnr.24249  0.706
2017 Delic V, Griffin JWD, Zivkovic S, Zhang Y, Phan TA, Gong H, Chaput D, Reynes C, Dinh VB, Cruz J, Cvitkovic E, Placides D, Frederic E, Mirzaei H, Stevens SM, ... ... Bradshaw PC, et al. Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein. Neuromolecular Medicine. PMID 28620826 DOI: 10.1007/S12017-017-8448-8  0.725
2017 Sawmiller D, Li S, Mori T, Habib A, Rongo D, Delic V, Bradshaw PC, Shytle RD, Sanberg C, Bickford P, Tan J. Beneficial effects of a pyrroloquinolinequinone-containing dietary formulation on motor deficiency, cognitive decline and mitochondrial dysfunction in a mouse model of Alzheimer's disease. Heliyon. 3: e00279. PMID 28413833 DOI: 10.1016/J.Heliyon.2017.E00279  0.796
2017 Griffin JW, Bradshaw PC. Amino Acid Catabolism in Alzheimer's Disease Brain: Friend or Foe? Oxidative Medicine and Cellular Longevity. 2017: 5472792. PMID 28261376 DOI: 10.1155/2017/5472792  0.751
2015 Copes N, Edwards C, Chaput D, Saifee M, Barjuca I, Nelson D, Paraggio A, Saad P, Lipps D, Stevens SM, Bradshaw PC. Metabolome and proteome changes with aging in Caenorhabditis elegans. Experimental Gerontology. 72: 67-84. PMID 26390854 DOI: 10.1016/J.Exger.2015.09.013  0.789
2015 O'Neal-Moffitt G, Delic V, Bradshaw PC, Olcese J. Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice. Molecular Neurodegeneration. 10: 27. PMID 26159703 DOI: 10.1186/S13024-015-0027-6  0.747
2015 Delic V, Brownlow M, Joly-Amado A, Zivkovic S, Noble K, Phan TA, Ta Y, Zhang Y, Bell SD, Kurien C, Reynes C, Morgan D, Bradshaw PC. Calorie restriction does not restore brain mitochondrial function in P301L tau mice, but it does decrease mitochondrial F0F1-ATPase activity. Molecular and Cellular Neurosciences. 67: 46-54. PMID 26048366 DOI: 10.1016/J.Mcn.2015.06.001  0.799
2015 Edwards C, Copes N, Bradshaw PC. D-ß-hydroxybutyrate: an anti-aging ketone body. Oncotarget. 6: 3477-8. PMID 25749208 DOI: 10.18632/Oncotarget.3423  0.799
2015 Edwards C, Canfield J, Copes N, Brito A, Rehan M, Lipps D, Brunquell J, Westerheide SD, Bradshaw PC. Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. Bmc Genetics. 16: 8. PMID 25643626 DOI: 10.1186/S12863-015-0167-2  0.785
2014 Edwards C, Canfield J, Copes N, Rehan M, Lipps D, Bradshaw PC. D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging. 6: 621-44. PMID 25127866 DOI: 10.18632/aging.100683  0.781
2013 Bradshaw PC, Pfeiffer DR. Characterization of the respiration-induced yeast mitochondrial permeability transition pore. Yeast (Chichester, England). 30: 471-83. PMID 24166770 DOI: 10.1002/Yea.2984  0.66
2013 Edwards CB, Copes N, Brito AG, Canfield J, Bradshaw PC. Malate and fumarate extend lifespan in Caenorhabditis elegans. Plos One. 8: e58345. PMID 23472183 DOI: 10.1371/Journal.Pone.0058345  0.809
2013 Edwards CB, Copes N, Brito AG, Canfield J, Bradshaw PC. Malate treatment increased C. elegans NAD and NADPH levels more than succinate. Plos One. DOI: 10.1371/Journal.Pone.0058345.G007  0.753
2012 Dragicevic N, Delic V, Cao C, Copes N, Lin X, Mamcarz M, Wang L, Arendash GW, Bradshaw PC. Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells. Neuropharmacology. 63: 1368-79. PMID 22959965 DOI: 10.1016/J.Neuropharm.2012.08.018  0.791
2011 Dragicevic N, Smith A, Lin X, Yuan F, Copes N, Delic V, Tan J, Cao C, Shytle RD, Bradshaw PC. Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer's amyloid-induced mitochondrial dysfunction. Journal of Alzheimer's Disease : Jad. 26: 507-21. PMID 21694462 DOI: 10.3233/Jad-2011-101629  0.791
2011 Dragicevic N, Bradshaw PC, Mamcarz M, Lin X, Wang L, Cao C, Arendash GW. Long-term electromagnetic field treatment enhances brain mitochondrial function of both Alzheimer's transgenic mice and normal mice: A mechanism for electromagnetic field-induced cognitive benefit? Neuroscience. 185: 135-149. PMID 21514369 DOI: 10.1016/J.Neuroscience.2011.04.012  0.52
2011 Dragicevic N, Copes N, O'Neal-Moffitt G, Jin J, Buzzeo R, Mamcarz M, Tan J, Cao C, Olcese JM, Arendash GW, Bradshaw PC. Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling. Journal of Pineal Research. 51: 75-86. PMID 21355879 DOI: 10.1111/J.1600-079X.2011.00864.X  0.82
2011 Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe CG, Ehrhart J, Bickford P, Mori T, Obregon D, et al. CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1355-65. PMID 21273420 DOI: 10.1523/Jneurosci.3268-10.2011  0.35
2010 Dragicevic N, Mamcarz M, Zhu Y, Buzzeo R, Tan J, Arendash GW, Bradshaw PC. Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice. Journal of Alzheimer's Disease : Jad. 20: S535-50. PMID 20463404 DOI: 10.3233/Jad-2010-100342  0.565
2007 Kujoth GC, Bradshaw PC, Haroon S, Prolla TA. The role of mitochondrial DNA mutations in mammalian aging. Plos Genetics. 3: e24. PMID 17319745 DOI: 10.1371/Journal.Pgen.0030024  0.601
2006 Bradshaw PC, Pfeiffer DR. Release of Ca2+ and Mg2+ from yeast mitochondria is stimulated by increased ionic strength. Bmc Biochemistry. 7: 4. PMID 16460565 DOI: 10.1186/1471-2091-7-4  0.663
2006 Bradshaw PC, Pfeiffer DR. Loss of NAD(H) from swollen yeast mitochondria. Bmc Biochemistry. 7: 3. PMID 16433924 DOI: 10.1186/1471-2091-7-3  0.641
2005 Bradshaw PC, Rathi A, Samuels DC. Mitochondrial-encoded membrane protein transcripts are pyrimidine-rich while soluble protein transcripts and ribosomal RNA are purine-rich. Bmc Genomics. 6: 136. PMID 16185363 DOI: 10.1186/1471-2164-6-136  0.615
2005 Bradshaw PC, Li J, Samuels DC. A computational model of mitochondrial AZT metabolism. The Biochemical Journal. 392: 363-73. PMID 16060859 DOI: 10.1042/Bj20050749  0.626
2005 Bradshaw PC, Samuels DC. A computational model of mitochondrial deoxynucleotide metabolism and DNA replication. American Journal of Physiology. Cell Physiology. 288: C989-1002. PMID 15634740 DOI: 10.1152/Ajpcell.00530.2004  0.6
2004 Jung DW, Bradshaw PC, Litsky M, Pfeiffer DR. Ca2+ transport in mitochondria from yeast expressing recombinant aequorin. Analytical Biochemistry. 324: 258-68. PMID 14690690 DOI: 10.1016/J.Ab.2003.10.029  0.573
2001 Mannella CA, Pfeiffer DR, Bradshaw PC, Moraru II, Slepchenko B, Loew LM, Hsieh CE, Buttle K, Marko M. Topology of the mitochondrial inner membrane: dynamics and bioenergetic implications. Iubmb Life. 52: 93-100. PMID 11798041 DOI: 10.1080/15216540152845885  0.635
2001 Bradshaw PC, Jung DW, Pfeiffer DR. Free fatty acids activate a vigorous Ca(2+):2H(+) antiport activity in yeast mitochondria. The Journal of Biological Chemistry. 276: 40502-9. PMID 11457848 DOI: 10.1074/Jbc.M105062200  0.581
1997 Jung DW, Bradshaw PC, Pfeiffer DR. Properties of a cyclosporin-insensitive permeability transition pore in yeast mitochondria. The Journal of Biological Chemistry. 272: 21104-12. PMID 9261114 DOI: 10.1074/Jbc.272.34.21104  0.615
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