Year |
Citation |
Score |
2023 |
Faber EB, Wang N, John K, Sun L, Wong HL, Burban D, Francis R, Tian D, Hong KH, Yang A, Wang L, Elsaid M, Khalid H, Levinson NM, Schönbrunn E, ... ... Georg GI, et al. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. Journal of Medicinal Chemistry. PMID 36701569 DOI: 10.1021/acs.jmedchem.2c01731 |
0.525 |
|
2021 |
Lee JC, Hong KH, Becker A, Tash JS, Schönbrunn E, Georg GI. Tetrahydroindazole inhibitors of CDK2/cyclin complexes. European Journal of Medicinal Chemistry. 214: 113232. PMID 33550184 DOI: 10.1016/j.ejmech.2021.113232 |
0.516 |
|
2020 |
Syeda SS, Sánchez G, McDermott JP, Hong KH, Blanco G, Georg GI. The Na+ and K+ transport system of sperm (ATP1A4) is essential for male fertility and an attractive target for male contraception†. Biology of Reproduction. PMID 32588885 DOI: 10.1093/Biolre/Ioaa093 |
0.525 |
|
2020 |
Holth TAD, Walters MA, Hutt OE, Georg GI. Diversity-Oriented Library Synthesis from Steviol and Isosteviol-Derived Scaffolds. Acs Combinatorial Science. PMID 32065745 DOI: 10.1021/Acscombsci.9B00186 |
0.31 |
|
2018 |
Jakkaraj S, Young VG, Georg GI. Syntheses of PDE3A inhibitor ORG9935 and determination of the absolute stereochemistries of its enantiomers by X-ray crystallography. Tetrahedron. 74: 2769-2774. PMID 30416214 DOI: 10.1016/J.Tet.2018.04.045 |
0.336 |
|
2018 |
Syeda SS, Sánchez G, Hong KH, Hawkinson JE, Georg GI, Blanco G. Design, Synthesis, in vitro and in vivo Evaluation of Ouabain Analogs as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception. Journal of Medicinal Chemistry. PMID 29291372 DOI: 10.1021/Acs.Jmedchem.7B00925 |
0.551 |
|
2017 |
Chen Y, Zhu JY, Hong KH, Mikles DC, Georg GI, Goldstein AS, Amory JK, Schönbrunn E. Structural basis of ALDH1A2 inhibition by irreversible and reversible small molecule inhibitors. Acs Chemical Biology. PMID 29240402 DOI: 10.1021/Acschembio.7B00685 |
0.582 |
|
2017 |
Huang DS, Wong HL, Georg GI. Synthesis and evaluation of C2 functionalized analogs of the α-tubulin-binding natural product pironetin. Bioorganic & Medicinal Chemistry Letters. PMID 29138028 DOI: 10.1016/J.Bmcl.2017.10.057 |
0.335 |
|
2017 |
Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, ... ... Georg GI, et al. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chemical Biology. PMID 28919040 DOI: 10.1016/J.Chembiol.2017.08.009 |
0.301 |
|
2017 |
Ayoub AM, Hawk LML, Herzig RJ, Jiang J, Wisniewski AJ, Gee CT, Zhao P, Zhu JY, Berndt N, Offei-Addo NK, Scott TG, Qi J, Bradner JE, Ward TR, Schönbrunn E, ... Georg GI, et al. Correction to BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen. Journal of Medicinal Chemistry. PMID 28696689 DOI: 10.1021/Acs.Jmedchem.7B00943 |
0.745 |
|
2017 |
Ayoub AM, Hawk LML, Herzig RJ, Jiang J, Wisniewski AJ, Gee CT, Zhao P, Zhu JY, Berndt N, Offei-Addo NK, Scott TG, Qi J, Bradner JE, Ward TR, Schönbrunn E, ... Georg GI, et al. BET Bromodomain Inhibitors With One-step Synthesis Discovered from Virtual Screen. Journal of Medicinal Chemistry. PMID 28535045 DOI: 10.1021/Acs.Jmedchem.6B01336 |
0.76 |
|
2017 |
Georg GI, Huang D, Wong H. Synthesis and cytotoxicity evaluation of C4 and C5 modified analogs of the -unsaturated lactone of pironetin. Chemmedchem. PMID 28261964 DOI: 10.1002/Cmdc.201700084 |
0.335 |
|
2016 |
Syeda SS, Rice D, Hook DJ, Heckert LL, Georg GI. Synthesis of Arylazide- and Diazirine-Containing CrAsH-EDT2 Photoaffinity Probes: Unfortunately, in the article. Archiv Der Pharmazie. 349: 572. PMID 27373873 DOI: 10.1002/Ardp.201670022 |
0.307 |
|
2016 |
Ranade AR, Higgins L, Markowski TW, Glaser N, Kashin D, Bai R, Hong KH, Hamel E, Höfle G, Georg GI. Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin. Journal of Medicinal Chemistry. PMID 26986898 DOI: 10.1021/Acs.Jmedchem.6B00188 |
0.556 |
|
2015 |
Patil S, Lis LG, Schumacher RJ, Norris BJ, Morgan ML, Cuellar RA, Blazar BR, Suryanarayanan R, Gurvich VJ, Georg GI. Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts. Journal of Medicinal Chemistry. PMID 26596892 DOI: 10.1021/Acs.Jmedchem.5B01329 |
0.512 |
|
2015 |
Li W, Schneider CM, Georg GI. Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro-Stephens Coupling/Alkyne Reduction Tandem Reactions. Organic Letters. 17: 3902-5. PMID 26176267 DOI: 10.1021/Acs.Orglett.5B01892 |
0.319 |
|
2015 |
Syeda SS, Jakkaraj S, Georg GI. Scalable syntheses of the BET bromodomain inhibitor JQ1. Tetrahedron Letters. 56: 3354-3457. PMID 26034331 DOI: 10.1016/J.Tetlet.2015.02.062 |
0.379 |
|
2015 |
Li W, Georg GI. A concise formal total synthesis of lactimidomycin. Chemical Communications (Cambridge, England). 51: 8634-6. PMID 25900419 DOI: 10.1039/C5Cc02571K |
0.367 |
|
2014 |
Seki H, Georg GI. Enantiospecific Synthesis and Biological Investigations of a Nuphar Alkaloid: Proposed Structure of a Castoreum Component. European Journal of Organic Chemistry. 2014: 3777-3783. PMID 25395879 DOI: 10.1002/Ejoc.201402232 |
0.568 |
|
2014 |
Yu YY, Georg GI. Biomimetic Aerobic C-H Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes. Advanced Synthesis & Catalysis. 356: 1359-1369. PMID 25071423 DOI: 10.1002/Adsc.201300904 |
0.532 |
|
2014 |
Ranade AR, Georg GI. Enantioselective synthesis of 3,4-dihydro-1,2-oxazepin-5(2H)-ones and 2,3-dihydropyridin-4(1H)-ones from β-substituted β-hydroxyaminoaldehydes. The Journal of Organic Chemistry. 79: 984-92. PMID 24785413 DOI: 10.1021/Jo402445R |
0.365 |
|
2014 |
Kim YW, Georg GI. Boron-Heck reaction of cyclic enaminones: regioselective direct arylation via oxidative palladium(II) catalysis. Organic Letters. 16: 1574-7. PMID 24650204 DOI: 10.1021/Ol500105D |
0.342 |
|
2014 |
Seki H, Georg GI. 2,3-dihydropyridin-4(1 H)-ones and 3-aminocyclohex-2-enones: Synthesis, functionalization, and applications to alkaloid synthesis Synlett. 25: 2536-2557. DOI: 10.1055/S-0034-1378529 |
0.592 |
|
2014 |
Yu YY, Ranade AR, Georg GI. Transition metal-free direct trifluoromethylation of 2,3-Dihydropyridin-4(1H)-ones at room temperature Advanced Synthesis and Catalysis. 356: 3510-3518. DOI: 10.1002/Adsc.201400417 |
0.431 |
|
2014 |
Yu Y, Georg GI. Cover Picture: Biomimetic Aerobic CH Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes (Adv. Synth. Catal. 6/2014) Advanced Synthesis & Catalysis. 356: 1125-1125. DOI: 10.1002/Adsc.201400050 |
0.497 |
|
2013 |
Gu X, Georg GI. Lithium Perchlorate-, Acetic Anhydride-, and Triphenylphosphine-assisted Multicomponent Syntheses of 4-Unsubstituted 2,5-Dioxooctahydroquinoline-3-carboxylates and 3-carbonitriles. Tetrahedron. 69: 9406-9416. PMID 31787785 DOI: 10.1016/J.Tet.2013.08.081 |
0.336 |
|
2013 |
Yu YY, Bi L, Georg GI. Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides. The Journal of Organic Chemistry. 78: 6163-9. PMID 23750615 DOI: 10.1021/Jo400830T |
0.521 |
|
2013 |
Hutt OE, Doan TL, Georg GI. Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviol. Organic Letters. 15: 1602-5. PMID 23530630 DOI: 10.1021/Ol400385W |
0.333 |
|
2013 |
Yu YY, Georg GI. Dehydrogenative alkenylation of uracils via palladium-catalyzed regioselective C-H activation. Chemical Communications (Cambridge, England). 49: 3694-6. PMID 23529083 DOI: 10.1039/C3Cc41130C |
0.502 |
|
2012 |
Chugh R, Sangwan V, Patil SP, Dudeja V, Dawra RK, Banerjee S, Schumacher RJ, Blazar BR, Georg GI, Vickers SM, Saluja AK. A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer. Science Translational Medicine. 4: 156ra139. PMID 23076356 DOI: 10.1126/Scitranslmed.3004334 |
0.507 |
|
2012 |
Niphakis MJ, Gay BC, Hong KH, Bleeker NP, Georg GI. Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs. Bioorganic & Medicinal Chemistry. 20: 5893-900. PMID 22910225 DOI: 10.1016/J.Bmc.2012.07.044 |
0.768 |
|
2012 |
Lee JC, Francis S, Dutta D, Gupta V, Yang Y, Zhu JY, Tash JS, Schönbrunn E, Georg GI. Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases. The Journal of Organic Chemistry. 77: 3082-98. PMID 22432895 DOI: 10.1021/Jo202054G |
0.359 |
|
2012 |
Sangwan V, Chugh R, Patil SP, Georg GI, Vickers SM, Saluja AK. Abstract A105: Minnelide, a potent chemotherapeutic agent, causes pancreatic tumor regression. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A105 |
0.5 |
|
2011 |
Yu YY, Niphakis MJ, Georg GI. Palladium(II)-catalyzed dehydrogenative alkenylation of cyclic enaminones via the Fujiwara-Moritani reaction. Organic Letters. 13: 5932-5. PMID 21995751 DOI: 10.1021/Ol202677G |
0.511 |
|
2011 |
Leighty MW, Georg GI. Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A. Acs Medicinal Chemistry Letters. 2: 313-315. PMID 21779519 DOI: 10.1021/Ml1003074 |
0.352 |
|
2011 |
Schneider CM, Khownium K, Li W, Spletstoser JT, Haack T, Georg GI. Synthesis of oximidine II by a copper-mediated reductive ene-yne macrocyclization. Angewandte Chemie (International Ed. in English). 50: 7855-7. PMID 21717556 DOI: 10.1002/Anie.201103081 |
0.331 |
|
2011 |
Seki H, Georg GI. Three-component synthesis of cyclic enaminones via ketene cyclization. Organic Letters. 13: 2147-9. PMID 21456588 DOI: 10.1021/Ol200358H |
0.572 |
|
2011 |
Pepe A, Pamment M, Georg GI, Malhotra SV. Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines. The Journal of Organic Chemistry. 76: 3527-30. PMID 21452823 DOI: 10.1021/Jo102558U |
0.305 |
|
2011 |
Niphakis MJ, Georg GI. Synthesis of tylocrebrine and related phenanthroindolizidines by VOF3-mediated oxidative aryl-alkene coupling. Organic Letters. 13: 196-9. PMID 21142214 DOI: 10.1021/Ol1023954 |
0.355 |
|
2011 |
Seki H, Georg GI. Synthesis of Cyclic Enaminones via Ketene Cyclization Synfacts. 2011: 711-711. DOI: 10.1055/S-0030-1260523 |
0.362 |
|
2010 |
Seki H, Georg GI. Synthesis of amino acid derived enaminones via Wolff rearrangement using vinylogous amides as carbon nucleophiles. Journal of the American Chemical Society. 132: 15512-3. PMID 20958040 DOI: 10.1021/Ja107329K |
0.587 |
|
2010 |
Niphakis MJ, Turunen BJ, Georg GI. Synthesis of 6- and 7-membered cyclic enaminones: scope and mechanism. The Journal of Organic Chemistry. 75: 6793-805. PMID 20929269 DOI: 10.1021/Jo100907U |
0.763 |
|
2010 |
Niphakis MJ, Georg GI. Total syntheses of arylindolizidine alkaloids (+)-ipalbidine and (+)-antofine. The Journal of Organic Chemistry. 75: 6019-22. PMID 20704319 DOI: 10.1021/Jo101051W |
0.368 |
|
2010 |
Reiff EA, Nair SK, Henri JT, Greiner JF, Reddy BS, Chakrasali R, David SA, Chiu TL, Amin EA, Himes RH, Vander Velde DG, Georg GI. Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin. The Journal of Organic Chemistry. 75: 86-94. PMID 19954175 DOI: 10.1021/Jo901752V |
0.388 |
|
2010 |
Chugh R, Patil S, Sangwan V, Vickers S, Georg G, Saluja AK. Abstract 1771: Therapeutic management of pancreatic cancer using a novel drug, Minnelide Cancer Research. 70: 1771-1771. DOI: 10.1158/1538-7445.Am10-1771 |
0.522 |
|
2010 |
Chugh R, Patil S, Sangwan V, Vickers SM, Georg GI, Saluja AK. 570 Minnelide as an Emerging Single Therapeutic Agent Against Pancreatic Cancer Gastroenterology. 138: S-80. DOI: 10.1016/S0016-5085(10)60365-4 |
0.498 |
|
2009 |
Ward TR, Turunen BJ, Haack T, Neuenswander B, Shadrick W, Georg GI. Synthesis of a quinolone library from ynones. Tetrahedron Letters. 50: 6494-9497. PMID 20161410 DOI: 10.1016/J.Tetlet.2009.09.024 |
0.77 |
|
2009 |
Hutt OE, Inagaki J, Reddy BS, Nair SK, Reiff EA, Henri JT, Greiner JF, VanderVelde DG, Chiu TL, Amin EA, Himes RH, Georg GI. Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of beta-tubulin. Bioorganic & Medicinal Chemistry Letters. 19: 3293-6. PMID 19428248 DOI: 10.1016/J.Bmcl.2009.04.077 |
0.306 |
|
2008 |
Ge H, Wang J, Kayser MM, Himes RH, Georg GI. Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5'-hydroxybutitaxel. Bioorganic & Medicinal Chemistry Letters. 18: 6165-7. PMID 18977659 DOI: 10.1016/J.Bmcl.2008.10.010 |
0.607 |
|
2008 |
Turunen BJ, Ge H, Oyetunji J, Desino KE, Vasandani V, Güthe S, Himes RH, Audus KL, Seelig A, Georg GI. Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability. Bioorganic & Medicinal Chemistry Letters. 18: 5971-4. PMID 18926701 DOI: 10.1016/J.Bmcl.2008.09.103 |
0.775 |
|
2008 |
Hutt OE, Reddy BS, Nair SK, Reiff EA, Henri JT, Greiner JF, Chiu TL, Vandervelde DG, Amin EA, Himes RH, Georg GI. Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells. Bioorganic & Medicinal Chemistry Letters. 18: 4904-6. PMID 18684624 DOI: 10.1016/J.Bmcl.2008.07.024 |
0.303 |
|
2008 |
Scott Kimball F, Himes RH, Georg GI. Synthesis and evaluation of heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones for cytotoxicity against the HCT-116 colon cancer cell line. Bioorganic & Medicinal Chemistry Letters. 18: 3248-50. PMID 18479919 DOI: 10.1016/J.Bmcl.2008.04.051 |
0.304 |
|
2008 |
Kimball FS, Turunen BJ, Ellis KC, Himes RH, Georg GI. Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers. Bioorganic & Medicinal Chemistry. 16: 4367-77. PMID 18343127 DOI: 10.1016/J.Bmc.2008.02.073 |
0.74 |
|
2008 |
Ge H, Niphakis MJ, Georg GI. Palladium(II)-catalyzed direct arylation of enaminones using organotrifluoroborates. Journal of the American Chemical Society. 130: 3708-9. PMID 18321102 DOI: 10.1021/Ja710221C |
0.612 |
|
2008 |
Vedantham P, Guerra JM, Schoenen F, Huang M, Gor PJ, Georg GI, Wang JL, Neuenswander B, Lushington GH, Mitscher LA, Ye QZ, Hanson PR. Ionic immobilization, diversification, and release: application to the generation of a library of methionine aminopeptidase inhibitors. Journal of Combinatorial Chemistry. 10: 185-94. PMID 18163595 DOI: 10.1021/Cc700085C |
0.305 |
|
2008 |
Vedantham P, Zhang M, Gor PJ, Huang M, Georg GI, Lushington GH, Mitscher LA, Ye QZ, Hanson PR. Studies towards the synthesis of methionine aminopeptidase inhibitors: diversification utilizing a ROMP-derived coupling reagent. Journal of Combinatorial Chemistry. 10: 195-203. PMID 18163594 DOI: 10.1021/Cc7000869 |
0.403 |
|
2007 |
Wang X, Turunen BJ, Leighty MW, Georg GI. Microwave-assisted Suzuki-Miyaura couplings on α-iodoenaminones. Tetrahedron Letters. 48: 8811-8814. PMID 19079569 DOI: 10.1016/J.Tetlet.2007.10.078 |
0.745 |
|
2007 |
Kimball FS, Tunoori AR, Victory SF, Dutta D, White JM, Himes RH, Georg GI. Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones. Bioorganic & Medicinal Chemistry Letters. 17: 4703-7. PMID 17614274 DOI: 10.1016/J.Bmcl.2007.05.103 |
0.309 |
|
2007 |
Fried KW, Schneider CM, Schramm KW, Datta A, Chahbane N, Corsten C, Powell DR, Lenoir D, Kettrup A, Terranova P, Georg GI, Rozman KK. From dioxin to drug lead--the development of 2,3,7,8-tetrachlorophenothiazine. Chemmedchem. 2: 890-7. PMID 17394264 DOI: 10.1002/Cmdc.200700005 |
0.305 |
|
2007 |
Spletstoser JT, White JM, Tunoori AR, Georg GI. Mild and selective hydrozirconation of amides to aldehydes using Cp2Zr(H)Cl: scope and mechanistic insight. Journal of the American Chemical Society. 129: 3408-19. PMID 17315870 DOI: 10.1021/Ja066362+ |
0.35 |
|
2007 |
Ge H, Spletstoser JT, Yang Y, Kayser M, Georg GI. Synthesis of docetaxel and butitaxel analogues through kinetic resolution of racemic beta-lactams with 7-O-triethylsilylbaccatin III. The Journal of Organic Chemistry. 72: 756-9. PMID 17253791 DOI: 10.1021/Jo061339S |
0.597 |
|
2007 |
Ahn YM, Vogeti L, Liu CJ, Santhapuram HK, White JM, Vasandani V, Mitscher LA, Lushington GH, Hanson PR, Powell DR, Himes RH, Roby KF, Ye Q, Georg GI. Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues. Bioorganic & Medicinal Chemistry. 15: 702-13. PMID 17123821 DOI: 10.1016/J.Bmc.2006.10.063 |
0.327 |
|
2006 |
Turunen BJ, Georg GI. Amino acid-derived enaminones: a study in ring formation providing valuable asymmetric synthons. Journal of the American Chemical Society. 128: 8702-3. PMID 16819843 DOI: 10.1021/Ja0609046 |
0.755 |
|
2006 |
Spletstoser JT, Turunen BJ, Desino K, Rice A, Datta A, Dutta D, Huff JK, Himes RH, Audus KL, Seelig A, Georg GI. Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells. Bioorganic & Medicinal Chemistry Letters. 16: 495-8. PMID 16289636 DOI: 10.1016/J.Bmcl.2005.10.063 |
0.735 |
|
2006 |
Ge H, Vasandani V, Huff JK, Audus KL, Himes RH, Seelig A, Georg GI. Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells. Bioorganic & Medicinal Chemistry Letters. 16: 433-6. PMID 16271474 DOI: 10.1016/J.Bmcl.2005.09.043 |
0.598 |
|
2006 |
Georg G, Turunen B. Synthesis of Cyclic and Bicyclic Enaminones from β-Amino Acids Synfacts. 2006: 1000-1000. DOI: 10.1055/s-2006-949357 |
0.739 |
|
2005 |
Beck ZQ, Aldrich CC, Magarvey NA, Georg GI, Sherman DH. Chemoenzymatic synthesis of cryptophycin/arenastatin natural products. Biochemistry. 44: 13457-66. PMID 16216069 DOI: 10.1021/Bi051140U |
0.322 |
|
2005 |
Haack T, Haack K, Diederich WE, Blackman B, Roy S, Pusuluri S, Georg GI. Formal total syntheses of the (-)-salicylihalamides A and B from D-glucose and L-rhamnose. The Journal of Organic Chemistry. 70: 7592-604. PMID 16149788 DOI: 10.1021/Jo050750X |
0.349 |
|
2004 |
Spletstoser JT, Flaherty PT, Himes RH, Georg GI. Synthesis and anti-tubulin activity of a 3'-(4-azidophenyl)-3'-dephenylpaclitaxel photoaffinity probe. Journal of Medicinal Chemistry. 47: 6459-65. PMID 15588080 DOI: 10.1021/Jm030581D |
0.375 |
|
2004 |
Buck SB, Huff JK, Himes RH, Georg GI. Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24. Journal of Medicinal Chemistry. 47: 3697-9. PMID 15214797 DOI: 10.1021/Jm030555F |
0.302 |
|
2004 |
White JM, Tunoori AR, Turunen BJ, Georg GI. [Bis(2-methoxyethyl)amino]sulfur trifluoride, the Deoxo-Fluor reagent: application toward one-flask transformations of carboxylic acids to amides. The Journal of Organic Chemistry. 69: 2573-6. PMID 15049661 DOI: 10.1021/Jo035658K |
0.756 |
|
2004 |
Barboni L, Giarlo G, Ricciutelli M, Ballini R, Georg GI, VanderVelde DG, Himes RH, Wang M, Lakdawala A, Snyder JP. Synthesis, modeling, and anti-tubulin activity of a D-seco paclitaxel analogue. Organic Letters. 6: 461-4. PMID 14961598 DOI: 10.1021/Ol036204C |
0.342 |
|
2004 |
Buck SB, Huff JK, Himes RH, Georg GI. Total synthesis and antitubulin activity of c10 analogues of cryptophycin-24. Journal of Medicinal Chemistry. 47: 696-702. PMID 14736249 DOI: 10.1021/Jm030278C |
0.317 |
|
2004 |
Tripathy NK, Georg GI. RCM approach for the total synthesis of cryptophycin-24 (Arenastatin A) Tetrahedron Letters. 45: 5309-5311. DOI: 10.1016/J.Tetlet.2004.04.164 |
0.352 |
|
2004 |
Spletstoser JT, White JM, Georg GI. One-step facile synthesis of deuterium labeled aldehydes from tertiary amides using Cp2Zr(D)Cl Tetrahedron Letters. 45: 2787-2789. DOI: 10.1016/J.Tetlet.2004.02.030 |
0.324 |
|
2003 |
Haack T, Kurtkaya S, Snyder JP, Georg GI. Studies toward the synthesis of oximidines I and II. Organic Letters. 5: 5019-22. PMID 14682754 DOI: 10.1021/Ol036007D |
0.356 |
|
2003 |
Yang K, Blackman B, Diederich W, Flaherty PT, Mossman CJ, Roy S, Ahn YM, Georg GI. Formal total synthesis of (+)-salicylihalamides A and B: a combined chiral pool and RCM strategy. The Journal of Organic Chemistry. 68: 10030-9. PMID 14682697 DOI: 10.1021/Jo0301550 |
0.352 |
|
2003 |
Vidya R, Eggen M, Nair SK, Georg GI, Himes RH. Synthesis of cryptophycins via an N-acyl-beta-lactam macrolactonization. The Journal of Organic Chemistry. 68: 9687-93. PMID 14656095 DOI: 10.1021/Jo0302197 |
0.336 |
|
2003 |
Rice A, Michaelis ML, Georg G, Liu Y, Turunen B, Audus KL. Overcoming the blood-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors. Journal of Molecular Neuroscience : Mn. 20: 339-43. PMID 14501017 DOI: 10.1385/Jmn:20:3:339 |
0.727 |
|
2003 |
Vidya R, Eggen M, Georg GI, Himes RH. Cryptophycin affinity labels: synthesis and biological activity of a benzophenone analogue of cryptophycin-24. Bioorganic & Medicinal Chemistry Letters. 13: 757-60. PMID 12639575 DOI: 10.1016/S0960-894X(02)01023-5 |
0.344 |
|
2003 |
Li G, Faibushevich A, Turunen BJ, Yoon SO, Georg G, Michaelis ML, Dobrowsky RT. Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons. Journal of Neurochemistry. 84: 347-62. PMID 12558997 DOI: 10.1046/J.1471-4159.2003.01526.X |
0.724 |
|
2003 |
Boger DL, Brotherton CE, Georg GI. Preparation and Three‐Carbon + Two‐Carbon Cycloaddition of Cyclopropenone 1,3‐propanediol ketal: 5,5‐Dicyano‐4‐phenyl‐2‐cyclopenten‐1‐one 1,3‐propanediol ketal Organic Syntheses. 32-32. DOI: 10.1002/0471264180.Os065.06 |
0.485 |
|
2002 |
Liu Y, Ali SM, Boge TC, Georg GI, Victory S, Zygmunt J, Marquez RT, Himes RH. A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach. Combinatorial Chemistry & High Throughput Screening. 5: 39-48. PMID 11860338 DOI: 10.2174/1386207023330615 |
0.317 |
|
2002 |
Eggen M, Georg GI. The cryptophycins: their synthesis and anticancer activity. Medicinal Research Reviews. 22: 85-101. PMID 11857635 DOI: 10.1002/Med.10002 |
0.338 |
|
2001 |
Krishna Reddy SH, Lee S, Datta A, Georg GI. Efficient synthesis of the 3'-phenolic metabolite of paclitaxel. The Journal of Organic Chemistry. 66: 8211-4. PMID 11722227 DOI: 10.1021/Jo0102516 |
0.316 |
|
2001 |
Eggen M, Nair SK, Georg GI. Rapid entry into the cryptophycin core via an acyl-beta-lactam macrolactonization: total synthesis of cryptophycin-24. Organic Letters. 3: 1813-5. PMID 11405718 DOI: 10.1021/Ol010044S |
0.32 |
|
2001 |
Barboni L, Datta A, Dutta D, Georg GI, Vander Velde DG, Himes RH, Wang M, Snyder JP. Novel d-seco paclitaxel analogues: synthesis, biological evaluation, and model testing. The Journal of Organic Chemistry. 66: 3321-9. PMID 11348113 DOI: 10.1021/Jo0015467 |
0.336 |
|
2001 |
Georg GI, Yu Mi Ahn, Blackman B, Farokhi F, Flaherty PT, Mossman CJ, Roy S, Yang K. Short and efficient chiral pool and RCM approach towards the synthesis of the macrocyclic core of the salicylihalamides Chemical Communications. 255-256. DOI: 10.1039/B008842K |
0.317 |
|
2000 |
Tunoori AR, White JM, Georg GI. A one-flask synthesis of Weinreb amides from chiral and achiral carboxylic acids using the deoxo-fluor fluorinating reagent. Organic Letters. 2: 4091-3. PMID 11112651 DOI: 10.1021/Ol000318W |
0.359 |
|
2000 |
Eggen M, Mossman CJ, Buck SB, Nair SK, Bhat L, Ali SM, Reiff EA, Boge TC, Georg GI. Total synthesis of cryptophycin-24 (Arenastatin A) amenable to structural modifications in the C16 side chain. The Journal of Organic Chemistry. 65: 7792-9. PMID 11073583 DOI: 10.1021/Jo000767+ |
0.344 |
|
1999 |
Krise JP, Zygmunt J, Georg GI, Stella VJ. Novel prodrug approach for tertiary amines: synthesis and preliminary evaluation of N-phosphonooxymethyl prodrugs. Journal of Medicinal Chemistry. 42: 3094-100. PMID 10447953 DOI: 10.1021/Jm980539W |
0.383 |
|
1998 |
Bhat L, Liu Y, Victory SF, Himes RH, Georg GI. Synthesis and evaluation of paclitaxel C7 derivatives: solution phase synthesis of combinatorial libraries. Bioorganic & Medicinal Chemistry Letters. 8: 3181-6. PMID 9873699 DOI: 10.1016/S0960-894X(98)00551-4 |
0.315 |
|
1998 |
Eggen MJ, Georg GI. Enantioselective synthesis of a 3'-dephenylcryptophycin synthon. Bioorganic & Medicinal Chemistry Letters. 8: 3177-80. PMID 9873698 DOI: 10.1016/S0960-894X(98)00557-5 |
0.344 |
|
1998 |
Georg GI, Ali SM, Stella VJ, Waugh WN, Himes RH. Halohydrin analogues of cryptophycin 1: synthesis and biological activity. Bioorganic & Medicinal Chemistry Letters. 8: 1959-62. PMID 9873466 DOI: 10.1016/S0960-894X(98)00356-4 |
0.344 |
|
1998 |
Georg GI, Harriman GCB, Datta A, Ali S, Cheruvallath Z, Dutta D, Vander Velde DG, Himes RH. The chemistry of the taxane diterpene: Stereoselective reductions of taxanes Journal of Organic Chemistry. 63: 8926-8934. DOI: 10.1021/Jo981194S |
0.343 |
|
1997 |
Sengupta S, Boge TC, Liu Y, Hepperle M, Georg GI, Himes RH. Probing the environment of tubulin-bound paclitaxel using fluorescent paclitaxel analogues. Biochemistry. 36: 5179-84. PMID 9136879 DOI: 10.1021/Bi962891M |
0.303 |
|
1997 |
Ali SM, Hoemann MZ, Aubé J, Georg GI, Mitscher LA, Jayasinghe LR. Butitaxel analogues: synthesis and structure-activity relationships. Journal of Medicinal Chemistry. 40: 236-41. PMID 9003522 DOI: 10.1021/Jm960505T |
0.322 |
|
1997 |
Ali SM, Georg GI. Formal syntheses of cryptophycin A and arenastatin A Tetrahedron Letters. 38: 1703-1706. DOI: 10.1016/S0040-4039(97)00194-9 |
0.373 |
|
1996 |
Georg GI, Harriman GC, Hepperle M, Clowers JS, Vander Velde DG, Himes RH. Synthesis, Conformational Analysis, and Biological Evaluation of Heteroaromatic Taxanes. The Journal of Organic Chemistry. 61: 2664-2676. PMID 11667096 DOI: 10.1021/Jo951961C |
0.312 |
|
1996 |
Park H, Hepperle M, Boge TC, Himes RH, Georg GI. Preparation of phenolic paclitaxel metabolites. Journal of Medicinal Chemistry. 39: 2705-9. PMID 8709100 DOI: 10.1021/Jm960142X |
0.319 |
|
1996 |
Wu Z, Georg GI, Cathers BE, Schloss JV. Synthesis and evaluation of a β-lactam-containing dipeptide analog as a protease inhibitor Bioorganic and Medicinal Chemistry Letters. 6: 983-986. DOI: 10.1016/0960-894X(96)00153-9 |
0.319 |
|
1995 |
Ali SM, Hoemann MZ, Aubé J, Mitscher LA, Georg GI, McCall R, Jayasinghe LR. Novel cytotoxic 3'-(tert-butyl) 3'-dephenyl analogs of paclitaxel and docetaxel. Journal of Medicinal Chemistry. 38: 3821-8. PMID 7562913 DOI: 10.1021/Jm00019A012 |
0.346 |
|
1995 |
Hoemann MZ, Velde DV, Aubé J, Georg GI, Jayasinghe LR. Synthesis of 13-epi-taxol via a transannular delivery of a borohydride reagent Journal of Organic Chemistry. 60: 2918-2921. DOI: 10.1021/Jo00114A052 |
0.329 |
|
1995 |
Georg GI, Boge TC, Park H, Himes RH. Paclitaxel and docetaxel photoaffinity labels Bioorganic and Medicinal Chemistry Letters. 5: 615-620. DOI: 10.1016/0960-894X(95)00083-6 |
0.317 |
|
1995 |
Georg GI, Ali SM, Boge TC, Datta A, Falborg L, Park H, Mejillano M, Himes RH. Synthesis of biologically active 2-benzoyl paclitaxel analogues Bioorganic and Medicinal Chemistry Letters. 5: 259-264. DOI: 10.1016/0960-894X(95)00020-T |
0.34 |
|
1995 |
Georg GI, Harriman GCB, Ali SM, Datta A, Hepperle M, Himes RH. Synthesis of 2-O-heteroaroyl taxanes: evaluation of microtubule assembly promotion and cytotoxicity Bioorganic and Medicinal Chemistry Letters. 5: 115-118. DOI: 10.1016/0960-894X(94)00468-U |
0.346 |
|
1995 |
Harriman GCB, Jalluri RK, Granewald GL, Vander Velde DG, Georg GI, Himes RH. The chemistry of the taxane diterpene: Stereoselective synthesis of 10-deacetoxy-11,12-epoxypaclitaxel Tetrahedron Letters. 36: 8909-8912. DOI: 10.1016/0040-4039(95)01928-B |
0.385 |
|
1995 |
Georg GI, Cheruvallath ZS, Vander Velde DG, Himes RH. Stereoselective synthesis of 9β-hydroxytaxanes via reduction with samarium diiodide Tetrahedron Letters. 36: 1783-1786. DOI: 10.1016/0040-4039(95)00142-Y |
0.309 |
|
1994 |
Datta A, Jayasinghe LR, Georg GI. 4-deacetyltaxol and 10-acetyl-4-deacetyltaxotere: Synthesis and biological evaluation Journal of Medicinal Chemistry®. 37: 4258-4260. PMID 7990125 DOI: 10.1021/Jm00050A023 |
0.312 |
|
1994 |
Boge TC, Himes RH, Vander Velde DG, Georg GI. The effect of the aromatic rings of taxol on biological activity and solution conformation: synthesis and evaluation of saturated taxol and taxotere analogues. Journal of Medicinal Chemistry. 37: 3337-43. PMID 7932561 DOI: 10.1021/Jm00046A018 |
0.339 |
|
1994 |
Jayasinghe LR, Datta A, Ali SM, Zygmunt J, Vander Velde DG, Georg GI. Structure-activity studies of antitumor taxanes: Synthesis of novel C-13 side chain homologated taxol and taxotere analogs Journal of Medicinal Chemistry. 37: 2981-2984. PMID 7915328 DOI: 10.1021/Jm00044A020 |
0.322 |
|
1994 |
Datta A, Jayasinghe LR, Georg GI. Internal nucleophile assisted selective deesterification studies on baccatin III. Synthesis of 2-debenzoyl- and 4-deacetylbaccatin III analogues Journal of Organic Chemistry. 59: 4689-4690. DOI: 10.1021/Jo00095A055 |
0.304 |
|
1994 |
Georg GI, Cheruvallath ZS. Samarium diiodide-mediated deoxygenation of taxol: A one-step synthesis of 10-deacetoxytaxol Journal of Organic Chemistry. 59: 4015-4018. DOI: 10.1021/Jo00093A040 |
0.332 |
|
1994 |
Datta A, Aubé J, Georg GI, Mitscher LA, Jayasinghe LR. The first synthesis of a C-9 carbonyl modified baccatin III derivative and its conversion to novel taxol® and taxotere® analogues Bioorganic and Medicinal Chemistry Letters. 4: 1831-1834. DOI: 10.1016/S0960-894X(01)80379-6 |
0.344 |
|
1994 |
Georg GI, Boge TC, Cheruvallath ZS, Harriman GCB, Hepperle M, Park H, Himes RH. Topliss approach to the synthesis of biologically active substituted N-benzoyl taxol analogues Bioorganic and Medicinal Chemistry Letters. 4: 1825-1830. DOI: 10.1016/S0960-894X(01)80378-4 |
0.34 |
|
1994 |
Georg GI, Harriman GCB, Hepperle M, Himes RH. Heteroaromatic Taxol Analogues: The Chemistry and Biological Activities of 3′-Furyl and 3′-Pyridyl Substituted Taxanes Bioorganic and Medicinal Chemistry Letters. 4: 1381-1384. DOI: 10.1016/S0960-894X(01)80366-8 |
0.367 |
|
1994 |
Georg GI, Boge TC, Cheruvallath ZS, Harriman GCB, Hepperle M, Park H, Himes RH. Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation Bioorganic and Medicinal Chemistry Letters. 4: 335-338. DOI: 10.1016/S0960-894X(01)80139-6 |
0.309 |
|
1994 |
Georg GI, Cheruvallath ZS, Harriman GCB, Hepperle M, Park H, Himes RH. Synthesis and biology of substituted 3′-phenyl taxol analogues Bioorganic and Medicinal Chemistry Letters. 4: 2331-2336. DOI: 10.1016/0960-894X(94)85035-6 |
0.375 |
|
1994 |
Georg GI, Harriman GCB, Park H, Himes RH. Taxol photoaffinity labels 2. Synthesis and biological evaluation of N-(4-azidobenzoyl)-N-debenzoyltaxol, N-(4-azido-2,3,5,6-tetrafluorobenzoyl)-N-debenzoyltaxol, and 7-(4-azido-2,3,5,6-tetrafluorobenzoyl)taxol Bioorganic and Medicinal Chemistry Letters. 4: 487-490. DOI: 10.1016/0960-894X(94)80022-7 |
0.314 |
|
1994 |
Georg GI, Ali SM, Boge TC, Datta A, Falborg L, Himes RH. Selective C-2 and C-4 deacylation and acylation of taxol: The first synthesis of a C-4 substituted taxol analogue Tetrahedron Letters. 35: 8931-8934. DOI: 10.1016/0040-4039(94)88392-0 |
0.324 |
|
1993 |
Georg GI, He P, Kant J, Wu ZJ. Stereocontrolled synthesis of N-vinyl-, N-(1′-propenyl)-, and N-unsubstituted-β-lactams from 2-aza-1,3-butadienes via the Staudinger reaction Journal of Organic Chemistry. 58: 5771-5778. DOI: 10.1021/Jo00073A042 |
0.315 |
|
1993 |
Georg GI, Cheruvallath ZS, Velde DV, Ye QM, Mitscher LA, Himes RH. Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate] Bioorganic and Medicinal Chemistry Letters. 3: 1349-1350. DOI: 10.1016/S0960-894X(00)80346-7 |
0.323 |
|
1992 |
Georg GI, Cheruvallath ZS, Himes RH, Mejillano MR, Burke CT. Synthesis of biologically active taxol analogues with modified phenylisoserine side chains. Journal of Medicinal Chemistry. 35: 4230-7. PMID 1359143 DOI: 10.1021/Jm00100A031 |
0.375 |
|
1992 |
Georg GI, Cheruvallath ZS, Himes RH, Mejillano MR. Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-chlorobenzoyl)-(2′R,3′S)-3′-phenylisoserinate ) and Baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-chlorophenyl)isoserinate ) Bioorganic and Medicinal Chemistry Letters. 2: 295-298. DOI: 10.1016/S0960-894X(01)80203-1 |
0.304 |
|
1992 |
Georg GI, Mashava PM, Akgun E, Milstead M. Erratum: Asymmetric synthesis of β-lactams and N-benzoyl-3-phenylisoserines via the Staudinger reaction (Tetrahedron Letters, 1991, 32 (3151-3154)) Tetrahedron Letters. 33. DOI: 10.1016/S0040-4039(00)91665-4 |
0.328 |
|
1992 |
Georg GI, Akgün E, Mashava PM, Milstead M, Ping H, Wu Zj, Velde DV, Takusagawa F. Galactose-Imines in the staudinger reaction Tetrahedron Letters. 33: 2111-2114. DOI: 10.1016/0040-4039(92)88153-V |
0.319 |
|
1991 |
Ojima I, Habus I, Zhao M, Georg GI, Jayasinghe LR. Efficient and practical asymmetric synthesis of the taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenylisoserine, and its analogues via chiral 3-hydroxy-4-aryl-β-lactams through chiral ester enolate-imine cyclocondensation Journal of Organic Chemistry. 56: 1681-1683. DOI: 10.1021/Jo00005A003 |
0.347 |
|
1991 |
Georg GI, Guan X, Kant J. Asymmetric synthesis of α-alkylated α-amino acids: azepane-2-carboxylic acids Bioorganic and Medicinal Chemistry Letters. 1: 125-128. DOI: 10.1016/S0960-894X(00)80245-0 |
0.699 |
|
1991 |
Georg GI, Mashava PM, Akgün E, Milstead MW. Asymmetric synthesis of β-lactams and n-benzoyl-3-phenylisoserines via the staudinger reaction Tetrahedron Letters. 32: 3151-3154. DOI: 10.1016/S0040-4039(00)79708-5 |
0.337 |
|
1991 |
Georg GI, Mashava PM, Guan X. An improved method for the stereoselective synthesis of β-lactams from carboxylic acids and imines Tetrahedron Letters. 32: 581-584. DOI: 10.1016/S0040-4039(00)74832-5 |
0.71 |
|
1988 |
Georg GI, Kant J. An asymmetric synthesis of carbapenem antibiotic (+)-PS-5 from ethyl 3-hydroxybutanoate Journal of Organic Chemistry. 53: 692-695. DOI: 10.1021/Jo00238A041 |
0.309 |
|
1988 |
Georg GI, Kant J, He P, Ly AM, Lampe L. 2-aza-1,3-dienes as novel precursors for the synthesis of N-unsubstituted β-lactams. A three step synthesis of 4-acetoxy-3-phenoxy-2-azeridinone Tetrahedron Letters. 29: 2409-2412. DOI: 10.1016/S0040-4039(00)87894-6 |
0.338 |
|
1988 |
Georg GI, Guan X, Kant J. Asymmetric synthesis of α-alkylated α-amino acids via Schmidt rearrangement of α, α-bisalkylated β-keto esters Tetrahedron Letters. 29: 403-406. DOI: 10.1016/S0040-4039(00)80107-0 |
0.675 |
|
1985 |
Georg GI, Gill HS, Gerhardt C. 3-(1′-hydroxyethyl)-2-azetidinones from 3-hydroxybutyrates and n-arylaldimines Tetrahedron Letters. 26: 3903-3906. DOI: 10.1016/S0040-4039(00)98683-0 |
0.306 |
|
1985 |
Georg GI, Pfeifer SA, Haake M. A one-step transformation of aromatic aldehydes to nitriles, using S,S-Dimethylsulfurdiimide as iminating agent. Isolation of dithiatetrazocines as reaction intermediates Tetrahedron Letters. 26: 2739-2742. DOI: 10.1016/S0040-4039(00)94899-8 |
0.318 |
|
1985 |
BOGER DL, BROTHERTON CE, GEORG GI. ChemInform Abstract: Effective Thermal One-Carbon + Two-Carbon Cycloaddition to Cyclopropenone Ketals with Electron-Deficient Olefins: Cyclopropane Formation. Thermal Three-Carbon + Two-Atom Cycloaddition of Cyclopropenone Ketals with Carbon-Heteroatom Do Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198514103 |
0.378 |
|
1984 |
Boger DL, Brotherton CE, Georg GI. Thermal, three-carbon + two-atom cycloaddition of cyclopropenone ketals with carbon-heteroatom double bonds: Butenolide, furan, and γ-keto ester preparation Tetrahedron Letters. 25: 5615-5618. DOI: 10.1016/S0040-4039(01)91394-2 |
0.415 |
|
1984 |
Georg GI. Stereoselective synthesis of 3-(1-Hydroxyethyl)-2-azetidinonesfrom 3-hydroxybutyrates Tetrahedron Letters. 25: 3779-3782. DOI: 10.1016/S0040-4039(01)91165-7 |
0.314 |
|
1983 |
Georg G, Haake M. A New Method for the Synthesis of Diaryl Sulfone Diimides andsec-Alkyl Aryl Sulfone Diimides Synthesis. 1983: 919-919. DOI: 10.1055/S-1983-30568 |
0.338 |
|
1983 |
Georg G, Durst T. Reaction of 4-(iodomethyl)azetidin-2-ones with tetracarbonylferrate(II) The Journal of Organic Chemistry. 48: 2092-2095. DOI: 10.1002/Chin.198346162 |
0.527 |
|
Show low-probability matches. |