| Year |
Citation |
Score |
| 2020 |
Vagrys D, Davidson J, Chen I, Hubbard RE, Davis B. Exploring IDP-Ligand Interactions: tau K18 as A Test Case. International Journal of Molecular Sciences. 21. PMID 32722166 DOI: 10.3390/Ijms21155257 |
0.337 |
|
| 2020 |
O'Brien P, Downes TD, Jones SP, Klein HF, Wheldon MC, Atobe M, Bond PS, Firth JD, Chan NS, Waddelove L, Hubbard RE, Blakemore DC, De Fusco C, Roughley SD, Vidler LR, et al. Design and Synthesis of 56 Shape Diverse 3-D Fragments. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32315100 DOI: 10.1002/Chem.202001123 |
0.306 |
|
| 2019 |
Darby JF, Hopkins AP, Shimizu S, Roberts SM, Brannigan JA, Turkenburg JP, Thomas GH, Hubbard RE, Fischer M. Water networks can determine the affinity of ligand binding to proteins. Journal of the American Chemical Society. PMID 31518131 DOI: 10.1021/Jacs.9B06275 |
0.605 |
|
| 2019 |
Szlávik Z, Ondi L, Csékei M, Paczal A, Szabó ZB, Radics G, Murray J, Davidson J, Chen I, Davis B, Hubbard RE, Pedder C, Dokurno P, Surgenor A, Smith J, et al. Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. Journal of Medicinal Chemistry. PMID 31339316 DOI: 10.1021/Acs.Jmedchem.9B00134 |
0.388 |
|
| 2019 |
Raingeval C, Cala O, Brion B, Le Borgne M, Hubbard RE, Krimm I. 1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery. Journal of Enzyme Inhibition and Medicinal Chemistry. 34: 1218-1225. PMID 31286785 DOI: 10.1080/14756366.2019.1636235 |
0.409 |
|
| 2018 |
Rachman MM, Barril X, Hubbard RE. Predicting how drug molecules bind to their protein targets. Current Opinion in Pharmacology. 42: 34-39. PMID 30041063 DOI: 10.1016/J.Coph.2018.07.001 |
0.418 |
|
| 2017 |
Lamoree B, Hubbard RE. Current perspectives in fragment-based lead discovery (FBLD). Essays in Biochemistry. 61: 453-464. PMID 29118093 DOI: 10.1042/Ebc20170028 |
0.365 |
|
| 2017 |
Williamson DS, Smith GP, Acheson-Dossang P, Bedford ST, Chell V, Chen IJ, Daechsel JCA, Daniels Z, David L, Dokurno P, Hentzer M, Herzig MC, Hubbard RE, Moore JD, Murray JB, et al. Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1). Journal of Medicinal Chemistry. PMID 29023112 DOI: 10.1021/Acs.Jmedchem.7B01186 |
0.332 |
|
| 2017 |
Ruiz-Carmona S, Schmidtke P, Luque FJ, Baker L, Matassova N, Davis B, Roughley S, Murray J, Hubbard R, Barril X. Dynamic undocking and the quasi-bound state as tools for drug discovery. Nature Chemistry. 9: 201-206. PMID 28221352 DOI: 10.1038/nchem.2660 |
0.322 |
|
| 2016 |
Renaud JP, Chung CW, Danielson UH, Egner U, Hennig M, Hubbard RE, Nar H. Biophysics in drug discovery: impact, challenges and opportunities. Nature Reviews. Drug Discovery. PMID 27516170 DOI: 10.1038/Nrd.2016.123 |
0.318 |
|
| 2015 |
Fischer M, Hopkins AP, Severi E, Hawkhead J, Bawdon D, Watts AG, Hubbard RE, Thomas GH. Tripartite ATP-independent periplasmic (TRAP) transporters use an arginine-mediated selectivity filter for high affinity substrate binding. The Journal of Biological Chemistry. PMID 26342690 DOI: 10.1074/Jbc.M115.656603 |
0.587 |
|
| 2014 |
Darby JF, Landström J, Roth C, He Y, Davies GJ, Hubbard RE. Discovery of selective small-molecule activators of a bacterial glycoside hydrolase. Angewandte Chemie (International Ed. in English). 53: 13419-23. PMID 25291993 DOI: 10.1002/Anie.201407081 |
0.318 |
|
| 2014 |
Ruiz-Carmona S, Alvarez-Garcia D, Foloppe N, Garmendia-Doval AB, Juhos S, Schmidtke P, Barril X, Hubbard RE, Morley SD. rDock: a fast, versatile and open source program for docking ligands to proteins and nucleic acids. Plos Computational Biology. 10: e1003571. PMID 24722481 DOI: 10.1371/Journal.Pcbi.1003571 |
0.363 |
|
| 2013 |
Meiby E, Simmonite H, le Strat L, Davis B, Matassova N, Moore JD, Mrosek M, Murray J, Hubbard RE, Ohlson S. Fragment screening by weak affinity chromatography: comparison with established techniques for screening against HSP90. Analytical Chemistry. 85: 6756-66. PMID 23806099 DOI: 10.1021/Ac400715T |
0.353 |
|
| 2013 |
Schulz MN, Landström J, Hubbard RE. MTSA--a Matlab program to fit thermal shift data. Analytical Biochemistry. 433: 43-7. PMID 23098701 DOI: 10.1016/J.Ab.2012.10.020 |
0.319 |
|
| 2012 |
Davies NG, Browne H, Davis B, Drysdale MJ, Foloppe N, Geoffrey S, Gibbons B, Hart T, Hubbard R, Jensen MR, Mansell H, Massey A, Matassova N, Moore JD, Murray J, et al. Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization. Bioorganic & Medicinal Chemistry. 20: 6770-89. PMID 23018093 DOI: 10.1016/J.Bmc.2012.08.050 |
0.411 |
|
| 2012 |
Roughley S, Wright L, Brough P, Massey A, Hubbard RE. Hsp90 inhibitors and drugs from fragment and virtual screening. Topics in Current Chemistry. 317: 61-82. PMID 21647838 DOI: 10.1007/128_2011_181 |
0.407 |
|
| 2012 |
Barril X, Hubbard RE, Morley SD. Virtual screening in structure-based drug discovery. Mini-Reviews in Medicinal Chemistry. 4: 779-791. PMID 15379645 DOI: 10.2174/1389557043403675 |
0.347 |
|
| 2011 |
Schulz MN, Landström J, Bright K, Hubbard RE. Design of a fragment library that maximally represents available chemical space. Journal of Computer-Aided Molecular Design. 25: 611-620. PMID 21792630 DOI: 10.1007/S10822-011-9461-X |
0.346 |
|
| 2011 |
Haider MK, Bertrand HO, Hubbard RE. Predicting fragment binding poses using a combined MCSS MM-GBSA approach. Journal of Chemical Information and Modeling. 51: 1092-105. PMID 21528911 DOI: 10.1021/Ci100469N |
0.445 |
|
| 2011 |
Hubbard RE, Murray JB. Experiences in fragment-based lead discovery. Methods in Enzymology. 493: 509-31. PMID 21371604 DOI: 10.1016/B978-0-12-381274-2.00020-0 |
0.332 |
|
| 2011 |
Fischer M, Leech AP, Hubbard RE. Comparative assessment of different histidine-tags for immobilization of protein onto surface plasmon resonance sensorchips. Analytical Chemistry. 83: 1800-7. PMID 21314134 DOI: 10.1021/Ac103168Q |
0.614 |
|
| 2011 |
Hubbard RE. Structure-based drug discovery and protein targets in the CNS. Neuropharmacology. 60: 7-23. PMID 20673774 DOI: 10.1016/J.Neuropharm.2010.07.016 |
0.416 |
|
| 2010 |
Fischer M, Zhang QY, Hubbard RE, Thomas GH. Caught in a TRAP: substrate-binding proteins in secondary transport. Trends in Microbiology. 18: 471-8. PMID 20656493 DOI: 10.1016/J.Tim.2010.06.009 |
0.572 |
|
| 2009 |
Brough PA, Barril X, Borgognoni J, Chene P, Davies NG, Davis B, Drysdale MJ, Dymock B, Eccles SA, Garcia-Echeverria C, Fromont C, Hayes A, Hubbard RE, Jordan AM, Jensen MR, et al. Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. Journal of Medicinal Chemistry. 52: 4794-809. PMID 19610616 DOI: 10.1021/Jm900357Y |
0.359 |
|
| 2009 |
Chen IJ, Hubbard RE. Lessons for fragment library design: analysis of output from multiple screening campaigns. Journal of Computer-Aided Molecular Design. 23: 603-20. PMID 19495994 DOI: 10.1007/S10822-009-9280-5 |
0.387 |
|
| 2009 |
Schulz MN, Hubbard RE. Recent progress in fragment-based lead discovery. Current Opinion in Pharmacology. 9: 615-21. PMID 19477685 DOI: 10.1016/J.Coph.2009.04.009 |
0.338 |
|
| 2009 |
Fischer M, Hubbard RE. Fragment-based ligand discovery. Molecular Interventions. 9: 22-30. PMID 19299661 DOI: 10.1124/Mi.9.1.7 |
0.602 |
|
| 2008 |
Hubbard RE. Fragment approaches in structure-based drug discovery. Journal of Synchrotron Radiation. 15: 227-30. PMID 18421145 DOI: 10.1107/S090904950705666X |
0.414 |
|
| 2008 |
Brough PA, Aherne W, Barril X, Borgognoni J, Boxall K, Cansfield JE, Cheung KM, Collins I, Davies NG, Drysdale MJ, Dymock B, Eccles SA, Finch H, Fink A, Hayes A, ... ... Hubbard RE, et al. 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. Journal of Medicinal Chemistry. 51: 196-218. PMID 18020435 DOI: 10.1021/Jm701018H |
0.322 |
|
| 2007 |
Hubbard RE, Davis B, Chen I, Drysdale MJ. The SeeDs approach: integrating fragments into drug discovery. Current Topics in Medicinal Chemistry. 7: 1568-81. PMID 17979768 DOI: 10.2174/156802607782341109 |
0.453 |
|
| 2007 |
Richardson CM, Nunns CL, Williamson DS, Parratt MJ, Dokurno P, Howes R, Borgognoni J, Drysdale MJ, Finch H, Hubbard RE, Jackson PS, Kierstan P, Lentzen G, Moore JD, Murray JB, et al. Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping. Bioorganic & Medicinal Chemistry Letters. 17: 3880-5. PMID 17570665 DOI: 10.1016/J.Bmcl.2007.04.110 |
0.396 |
|
| 2007 |
Sharp SY, Prodromou C, Boxall K, Powers MV, Holmes JL, Box G, Matthews TP, Cheung KM, Kalusa A, James K, Hayes A, Hardcastle A, Dymock B, Brough PA, Barril X, ... ... Hubbard RE, et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Molecular Cancer Therapeutics. 6: 1198-211. PMID 17431102 DOI: 10.1158/1535-7163.Mct-07-0149 |
0.353 |
|
| 2006 |
Rodrigues AP, Grant BJ, Hubbard RE. sgTarget: a target selection resource for structural genomics. Nucleic Acids Research. 34: W225-30. PMID 16844998 DOI: 10.1093/Nar/Gkl121 |
0.312 |
|
| 2005 |
Barril X, Brough P, Drysdale M, Hubbard RE, Massey A, Surgenor A, Wright L. Structure-based discovery of a new class of Hsp90 inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 5187-91. PMID 16202589 DOI: 10.1016/J.Bmcl.2005.08.092 |
0.411 |
|
| 2005 |
Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L, Drysdale MJ. Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. Journal of Medicinal Chemistry. 48: 4212-5. PMID 15974572 DOI: 10.1021/Jm050355Z |
0.411 |
|
| 2005 |
Kong EH, Heldring N, Gustafsson JA, Treuter E, Hubbard RE, Pike AC. Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor. Proceedings of the National Academy of Sciences of the United States of America. 102: 3593-8. PMID 15728727 DOI: 10.1073/Pnas.0407189102 |
0.383 |
|
| 2004 |
Baurin N, Aboul-Ela F, Barril X, Davis B, Drysdale M, Dymock B, Finch H, Fromont C, Richardson C, Simmonite H, Hubbard RE. Design and characterization of libraries of molecular fragments for use in NMR screening against protein targets. Journal of Chemical Information and Computer Sciences. 44: 2157-66. PMID 15554686 DOI: 10.1021/Ci049806Z |
0.38 |
|
| 2004 |
Wright L, Barril X, Dymock B, Sheridan L, Surgenor A, Beswick M, Drysdale M, Collier A, Massey A, Davies N, Fink A, Fromont C, Aherne W, Boxall K, Sharp S, ... ... Hubbard RE, et al. Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms. Chemistry & Biology. 11: 775-85. PMID 15217611 DOI: 10.1016/J.Chembiol.2004.03.033 |
0.419 |
|
| 2004 |
Dymock B, Barril X, Beswick M, Collier A, Davies N, Drysdale M, Fink A, Fromont C, Hubbard RE, Massey A, Surgenor A, Wright L. Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures. Bioorganic & Medicinal Chemistry Letters. 14: 325-8. PMID 14698151 DOI: 10.1016/J.Bmcl.2003.11.011 |
0.362 |
|
| 2003 |
Rodrigues A, Hubbard RE. Making decisions for structural genomics. Briefings in Bioinformatics. 4: 150-67. PMID 12846396 DOI: 10.1093/Bib/4.2.150 |
0.342 |
|
| 2003 |
Smith R, Hubbard RE, Gschwend DA, Leach AR, Good AC. Analysis and optimization of structure-based virtual screening protocols. (3). New methods and old problems in scoring function design. Journal of Molecular Graphics & Modelling. 22: 41-53. PMID 12798390 DOI: 10.1016/S1093-3263(03)00125-6 |
0.383 |
|
| 2002 |
Wärnmark A, Treuter E, Gustafsson JA, Hubbard RE, Brzozowski AM, Pike AC. Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha. The Journal of Biological Chemistry. 277: 21862-8. PMID 11937504 DOI: 10.1074/Jbc.M200764200 |
0.373 |
|
| 2002 |
Hubbard RE. What can structure tell us about function in the estrogen receptors Pharmacochemistry Library. 32: 53-56. DOI: 10.1016/S0165-7208(02)80007-1 |
0.354 |
|
| 2001 |
Kong EH, Pike ACW, Hubbard RE. Structure and mechanism of the oestrogen receptor. Biochemical Society Transactions. 31: 56-59. PMID 12546653 DOI: 10.1042/Bst0310056 |
0.377 |
|
| 2001 |
English AC, Groom CR, Hubbard RE. Experimental and computational mapping of the binding surface of a crystalline protein Protein Engineering. 14: 47-59. PMID 11287678 DOI: 10.1093/Protein/14.1.47 |
0.389 |
|
| 2001 |
Pike AC, Brzozowski AM, Walton J, Hubbard RE, Thorsell AG, Li YL, Gustafsson JA, Carlquist M. Structural insights into the mode of action of a pure antiestrogen. Structure (London, England : 1993). 9: 145-53. PMID 11250199 DOI: 10.1016/S0969-2126(01)00568-8 |
0.329 |
|
| 2001 |
Antson AA, Smith DJ, Roper DI, Lewis S, Caves LSD, Verma CS, Buckley SL, Lillford PJ, Hubbard RE. Understanding the mechanism of ice binding by type III antifreeze proteins. Journal of Molecular Biology. 305: 875-889. PMID 11162099 DOI: 10.1006/Jmbi.2000.4336 |
0.322 |
|
| 2000 |
Pike ACW, Brzozowski AM, Hubbard RE. A structural biologist's view of the oestrogen receptor The Journal of Steroid Biochemistry and Molecular Biology. 74: 261-268. PMID 11162934 DOI: 10.1016/S0960-0760(00)00102-3 |
0.359 |
|
| 2000 |
Hubbard RE, Pike ACW, Brzozowski AM, Walton J, Bonn T, Gustafsson J-, Carlquist M. Structural insights into the mechanisms of agonism and antagonism in oestrogen receptor isoforms European Journal of Cancer. 36: 17-18. PMID 11056300 DOI: 10.1016/S0959-8049(00)00207-0 |
0.363 |
|
| 2000 |
Wright LM, Brzozowski AM, Hubbard RE, Pike AC, Roberts SM, Skovgaard RN, Svendsen I, Vissing H, Bywater RP. Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor. Acta Crystallographica. Section D, Biological Crystallography. 56: 573-80. PMID 10771426 DOI: 10.1107/S090744490000233X |
0.317 |
|
| 2000 |
Pike ACW, Brzozowski AM, Walton J, Hubbard RE, Bonn T, Gustafsson J-, Carlquist M. Structural aspects of agonism and antagonism in the oestrogen receptor. Biochemical Society Transactions. 28: 396-400. DOI: 10.1042/Bst0280396 |
0.39 |
|
| 2000 |
Davies TG, Tame JRH, Hubbard RE. Generating consistent sets of thermodynamic and structural data for analysis of protein-ligand interactions Perspectives in Drug Discovery and Design. 20: 29-42. DOI: 10.1007/0-306-46883-2_3 |
0.413 |
|
| 1999 |
English AC, Done SH, Caves LSD, Groom CR, Hubbard RE. Locating interaction sites on proteins: The crystal structure of thermolysin soaked in 2% to 100% isopropanol Proteins: Structure, Function and Genetics. 37: 628-640. PMID 10651278 DOI: 10.1002/(Sici)1097-0134(19991201)37:4<628::Aid-Prot13>3.0.Co;2-G |
0.364 |
|
| 1999 |
Pike AC, Brzozowski AM, Hubbard RE, Bonn T, Thorsell AG, Engström O, Ljunggren J, Gustafsson JA, Carlquist M. Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. The Embo Journal. 18: 4608-18. PMID 10469641 DOI: 10.1093/Emboj/18.17.4608 |
0.377 |
|
| 1999 |
Davies TG, Hubbard RE, Tame JRH. Relating structure to thermodynamics: the crystal structures and binding affinity of eight OppA-peptide complexes. Protein Science. 8: 1432-1444. PMID 10422831 DOI: 10.1110/Ps.8.7.1432 |
0.409 |
|
| 1999 |
Lamers MB, Antson AA, Hubbard RE, Scott RK, Williams DH. Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine. Journal of Molecular Biology. 285: 713-25. PMID 9878439 DOI: 10.1006/Jmbi.1998.2369 |
0.345 |
|
| 1999 |
Jääskeläine S, Verma CS, Hubbard RE, Caves LSD. Identifying key electrostatic interactions in Rhizomucor miehei lipase: the influence of solvent dielectric Theoretical Chemistry Accounts: Theory, Computation, and Modeling (Theoretica Chimica Acta). 101: 175-179. DOI: 10.1007/S002140050426 |
0.31 |
|
| 1998 |
Done SH, Brannigan JA, Moody PCE, Hubbard RE. Ligand-induced conformational change in penicillin acylase. Journal of Molecular Biology. 284: 463-475. PMID 9813130 DOI: 10.1006/Jmbi.1998.2180 |
0.396 |
|
| 1998 |
Herzyk P, Hubbard RE. Combined biophysical and biochemical information confirms arrangement of transmembrane helices visible from the three-dimensional map of frog rhodopsin. Journal of Molecular Biology. 281: 741-754. PMID 9710543 DOI: 10.1006/Jmbi.1998.1981 |
0.323 |
|
| 1998 |
Kuschert GSV, Hoogewerf AJ, Proudfoot AEI, Chung C, Cooke RM, Hubbard RE, Wells TNC, Sanderson PN. Identification of a glycosaminoglycan binding surface on human interleukin-8. Biochemistry. 37: 11193-11201. PMID 9698365 DOI: 10.1021/Bi972867O |
0.304 |
|
| 1998 |
Jaaskelainen S, Verma CS, Hubbard RE, Linko P, Caves LSD. Conformational change in the activation of lipase: an analysis in terms of low-frequency normal modes. Protein Science. 7: 1359-1367. PMID 9655340 DOI: 10.1002/Pro.5560070612 |
0.302 |
|
| 1998 |
Afshar M, Hubbard RE, Demaille J. Towards structural models of molecular recognition in olfactory receptors Biochimie. 80: 129-135. PMID 9587670 DOI: 10.1016/S0300-9084(98)80019-9 |
0.339 |
|
| 1998 |
Herzyk P, Hubbard RE. Using Experimental Information to Produce a Model of the Transmembrane Domain of the Ion Channel Phospholamban Biophysical Journal. 74: 1203-1214. PMID 9512019 DOI: 10.1016/S0006-3495(98)77835-X |
0.301 |
|
| 1998 |
Fischer S, Verma CS, Hubbard RE. Rotation of Structural Water inside a Protein: Calculation of the Rate and Vibrational Entropy of Activation The Journal of Physical Chemistry B. 102: 1797-1805. DOI: 10.1021/Jp972948U |
0.308 |
|
| 1997 |
Prusis P, Schiöth HB, Muceniece R, Herzyk P, Afshar M, Hubbard RE, Wikberg JES. Modeling of the three-dimensional structure of the human melanocortin 1 receptor, using an automated method and docking of a rigid cyclic melanocyte-stimulating hormone core peptide Journal of Molecular Graphics & Modelling. 15: 307-317. PMID 9640562 DOI: 10.1016/S1093-3263(98)00004-7 |
0.301 |
|
| 1997 |
Hubbard RE. Can drugs be designed Current Opinion in Biotechnology. 8: 696-700. PMID 9425659 DOI: 10.1016/S0958-1669(97)80122-X |
0.322 |
|
| 1997 |
Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, Engström O, Ohman L, Greene GL, Gustafsson JA, Carlquist M. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature. 389: 753-8. PMID 9338790 DOI: 10.1038/39645 |
0.408 |
|
| 1997 |
Iversen LF, Brzozowski M, Hastrup S, Hubbard R, Kastrup JS, Larsen IK, Naerum L, Nørskov-Lauridsen L, Rasmussen PB, Thim L, Wiberg FC, Lundgren K. Characterization of the allosteric binding pocket of human liver fructose-1,6-bisphosphatase by protein crystallography and inhibitor activity studies. Protein Science : a Publication of the Protein Society. 6: 971-82. PMID 9144768 DOI: 10.1002/Pro.5560060503 |
0.414 |
|
| 1996 |
Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ, Proudfoot AE, Bernard AR, Payton MA, Wells TN. The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution. Nature Structural Biology. 3: 470-9. PMID 8612079 DOI: 10.1038/Nsb0596-470 |
0.302 |
|
| 1995 |
Herzyk P, Hubbard RE. Automated method for modeling seven-helix transmembrane receptors from experimental data Biophysical Journal. 69: 2419-2442. PMID 8599649 DOI: 10.1016/S0006-3495(95)80112-8 |
0.354 |
|
| 1995 |
Hartshorn MJ, Herzyk P, Hubbard RE. Exploring molecular structure by virtual reality Trends in Biotechnology. 13: 83-85. PMID 7766221 DOI: 10.1016/S0167-7799(00)88911-8 |
0.324 |
|
| 1994 |
Oldfield TJ, Hubbard RE. Analysis of C alpha geometry in protein structures. Proteins. 18: 324-37. PMID 8208725 DOI: 10.1002/Prot.340180404 |
0.318 |
|
| 1994 |
Afshar M, Caves LSD, Guimard L, Hubbard RE, Calas B, Grassy G, Haiech J. Investigating the high affinity and low sequence specificity of calmodulin binding to its targets. Journal of Molecular Biology. 244: 554-571. PMID 7990140 DOI: 10.1006/Jmbi.1994.1752 |
0.379 |
|
| 1994 |
Eisen MB, Wiley DC, Karplus M, Hubbard RE. HOOK: a program for finding novel molecular architectures that satisfy the chemical and steric requirements of a macromolecule binding site. Proteins. 19: 199-221. PMID 7937734 DOI: 10.1002/Prot.340190305 |
0.399 |
|
| 1993 |
Davies GJ, Dodson GG, Hubbard RE, Tolley SP, Dauter Z, Wilson KS, Hjort C, Mikkelsen JM, Rasmussen G, Schülein M. Structure and function of endoglucanase V Nature. 365: 362-364. PMID 8377830 DOI: 10.1038/365362A0 |
0.329 |
|
| 1992 |
Cooke RM, Carter BG, Murray-Rust P, Hartshorn MJ, Herzyk P, Hubbard RE. The solution structure of echistatin: evidence for disulphide bond rearrangement in homologous snake toxins. Protein Engineering. 5: 473-477. PMID 1438157 DOI: 10.1093/Protein/5.6.473 |
0.342 |
|
| 1990 |
Smerdon SJ, Oldfield TJ, Dodson EJ, Dodson GG, Hubbard RE, Wilkinson AJ. Determination of the crystal structure of recombinant pig myoglobin by molecular replacement and its refinement. Acta Crystallographica. Section B, Structural Science. 46: 370-7. PMID 2383370 DOI: 10.1107/S0108768189012450 |
0.319 |
|
| 1990 |
Hyde SC, Emsley P, Hartshorn MJ, Mimmack MM, Gileadi U, Pearce SR, Gallagher MP, Gill DR, Hubbard RE, Higgins CF. Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport Nature. 346: 362-365. PMID 1973824 DOI: 10.1038/346362A0 |
0.367 |
|
| 1989 |
Baker EN, Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DM, Hubbard RE, Isaacs NW, Reynolds CD. The structure of 2Zn pig insulin crystals at 1.5 A resolution. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 319: 369-456. PMID 2905485 DOI: 10.1098/Rstb.1988.0058 |
0.314 |
|
| 1988 |
Dodson G, Hubbard RE, Oldfield TJ, Smerdon SJ, Wilkinson AJ. Apomyoglobin as a molecular recognition surface: expression, reconstitution and crystallization of recombinant porcine myoglobin in Escherichia coli. Protein Engineering. 2: 233-7. PMID 3070546 DOI: 10.1093/Protein/2.3.233 |
0.322 |
|
| 1983 |
Hubbard RE. Colour molecular graphics on a microcomputer Journal of Molecular Graphics. 1: 13-16. DOI: 10.1016/0263-7855(83)80049-6 |
0.334 |
|
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