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Gary D. Glick - Publications

Affiliations: 
Biological Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
anti-DNA autoantibody structure and function, and the identification of novel molecular targets and small molecules for the treatment of autoimmune diseases and cancer
Website:
https://www.chem.lsa.umich.edu/chem/faculty/facultyDetail.php?Uniqname=gglick

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Targeting the NLRP3 inflammasome in inflammatory diseases. Nature Reviews. Drug Discovery. PMID 30026524 DOI: 10.1038/Nrd.2018.97  0.315
2018 Starke I, Glick GD, Börsch M. Visualizing Mitochondrial FF-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423. Frontiers in Physiology. 9: 803. PMID 30022951 DOI: 10.3389/Fphys.2018.00803  0.348
2017 Franchi L, Monteleone I, Hao LY, Spahr MA, Zhao W, Liu X, Demock K, Kulkarni A, Lesch CA, Sanchez B, Carter L, Marafini I, Hu X, Mashadova O, Yuan M, ... ... Glick GD, et al. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis. Journal of Immunology (Baltimore, Md. : 1950). PMID 28242647 DOI: 10.4049/Jimmunol.1600810  0.326
2016 Guo Y, MacIsaac KD, Chen Y, Miller RJ, Jain R, Joyce-Shaikh B, Ferguson H, Wang IM, Cristescu R, Mudgett J, Engstrom L, Piers KJ, Baltus GA, Barr K, Zhang H, ... ... Glick G, et al. Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity. Cell Reports. 17: 3206-3218. PMID 28009290 DOI: 10.1016/J.Celrep.2016.11.073  0.329
2016 Starke I, Johnson KM, Petersen J, Gräber P, Opipari AW, Glick GD, Börsch M. Binding of the immunomodulatory drug Bz-423 to mitochondrial F0F1-ATP synthase in living cells by FRET acceptor photobleaching Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9712. DOI: 10.1117/12.2209645  0.609
2015 Hu X, Wang Y, Hao LY, Liu X, Lesch CA, Sanchez BM, Wendling JM, Morgan RW, Aicher TD, Carter LL, Toogood PL, Glick GD. Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists. Nature Chemical Biology. 11: 141-7. PMID 25558972 DOI: 10.1038/Nchembio.1714  0.301
2015 von Stockum S, Giorgio V, Trevisan E, Lippe G, Glick GD, Forte MA, Da-Rè C, Checchetto V, Mazzotta G, Costa R, Szabò I, Bernardi P. F-ATPase of Drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release. The Journal of Biological Chemistry. 290: 4537-44. PMID 25550160 DOI: 10.1074/Jbc.C114.629766  0.309
2015 Hu X, Moisan J, Lesch C, Wang Y, Liu X, Morgan R, Mertz D, Sanchez B, Bousley D, Taylor C, Huis CV, Aicher T, Toogood P, Zou W, Glick G, et al. Abstract 4273: RORγ agonists as a novel immunotherapy approach for cancer Cancer Research. 75: 4273-4273. DOI: 10.1158/1538-7445.Am2015-4273  0.305
2014 Glick GD, Rossignol R, Lyssiotis CA, Wahl D, Lesch C, Sanchez B, Liu X, Hao LY, Taylor C, Hurd A, Ferrara JL, Tkachev V, Byersdorfer CA, Boros L, Opipari AW. Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease. The Journal of Pharmacology and Experimental Therapeutics. 351: 298-307. PMID 25125579 DOI: 10.1124/Jpet.114.218099  0.634
2014 Antoniel M, Giorgio V, Fogolari F, Glick GD, Bernardi P, Lippe G. The oligomycin-sensitivity conferring protein of mitochondrial ATP synthase: emerging new roles in mitochondrial pathophysiology. International Journal of Molecular Sciences. 15: 7513-36. PMID 24786291 DOI: 10.3390/Ijms15057513  0.435
2014 Hu X, Liu X, Morgan R, Moisan J, Hao L, Wang Y, Sanchez B, Lesch C, Bousley D, Taylor C, Aicher T, Toogood P, Zou W, Glick G, Carter L. Novel synthetic RORγ agonist compounds as a potential anti-tumor therapeutic approach Journal For Immunotherapy of Cancer. 2: P194. DOI: 10.1186/2051-1426-2-S3-P194  0.314
2014 Franchi L, Hlavaty KA, Monteleone I, Morgan R, Porzondek K, Sanchez B, Lesch C, Spahr MA, Hepburn C, Opipari AW, Monteleone G, Glick G, Carter L, Higgins PD. Su1387 F1F0-ATPase Modulation Is Efficacious in Models in IBD and Induces Apoptosis of Human CCR9+ Gut-Tropic T-cells Gastroenterology. 146: S-455. DOI: 10.1016/S0016-5085(14)61630-9  0.343
2014 Franchi L, Monteleone I, Morgan R, Opipari AW, Carter L, Glick G, Monteleone G. 593 Modulation of the F1F0-ATPase Induces Apoptosis of Mouse and Human Lamina Propria T-cells and Is Efficacious in Models of IBD Gastroenterology. 146: S-112. DOI: 10.1016/S0016-5085(14)60401-7  0.36
2013 Byersdorfer CA, Tkachev V, Opipari AW, Goodell S, Swanson J, Sandquist S, Glick GD, Ferrara JL. Effector T cells require fatty acid metabolism during murine graft-versus-host disease. Blood. 122: 3230-7. PMID 24046012 DOI: 10.1182/Blood-2013-04-495515  0.342
2013 Giorgio V, von Stockum S, Antoniel M, Fabbro A, Fogolari F, Forte M, Glick GD, Petronilli V, Zoratti M, Szabó I, Lippe G, Bernardi P. Dimers of mitochondrial ATP synthase form the permeability transition pore. Proceedings of the National Academy of Sciences of the United States of America. 110: 5887-92. PMID 23530243 DOI: 10.1073/Pnas.1217823110  0.315
2012 Wahl DR, Byersdorfer CA, Ferrara JL, Opipari AW, Glick GD. Distinct metabolic programs in activated T cells: opportunities for selective immunomodulation. Immunological Reviews. 249: 104-15. PMID 22889218 DOI: 10.1111/J.1600-065X.2012.01148.X  0.609
2012 Glick GD. Modulating the Mitochondrial F0F1-ATPase as Therapeutic Strategy for Systematic Autoimmunity Biophysical Journal. 102: 2a-3a. DOI: 10.1016/J.Bpj.2011.11.028  0.309
2011 He S, Kato K, Jiang J, Wahl DR, Mineishi S, Fisher EM, Murasko DM, Glick GD, Zhang Y. Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells. Plos One. 6: e20107. PMID 21611151 DOI: 10.1371/Journal.Pone.0020107  0.62
2011 Gatza E, Wahl DR, Opipari AW, Sundberg TB, Reddy P, Liu C, Glick GD, Ferrara JL. Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease. Science Translational Medicine. 3: 67ra8. PMID 21270339 DOI: 10.1126/Scitranslmed.3001975  0.803
2011 Wahl D, Gatza E, Opipari A, Sundberg T, Reddy P, Liu C, Glick G, Ferrara J. Manipulation of the Bioenergetics of Alloreactive T Cells Leads to Their Selective Apoptosis and Arrests Graft Versus Host Disease Biology of Blood and Marrow Transplantation. 17: S149. DOI: 10.1016/J.Bbmt.2010.12.003  0.771
2010 Wahl DR, Petersen B, Warner R, Richardson BC, Glick GD, Opipari AW. Characterization of the metabolic phenotype of chronically activated lymphocytes. Lupus. 19: 1492-501. PMID 20647250 DOI: 10.1177/0961203310373109  0.615
2010 Stelzer AC, Frazee RW, Van Huis C, Cleary J, Opipari AW, Glick GD, Al-Hashimi HM. NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase. Biopolymers. 93: 85-92. PMID 19768783 DOI: 10.1002/Bip.21306  0.646
2010 Garg G, Liu R, Boitano A, Tan L, Kwok R, Glick G, Opipari A. Abstract 4143: Bz-423, a novel benzodiazpine, inhibits PI3 kinase signaling in ovarian cancer cells Cancer Research. 70: 4143-4143. DOI: 10.1158/1538-7445.Am10-4143  0.667
2009 Sundberg TB, Swenson L, Wahl DR, Opipari AW, Glick GD. Apoptotic signaling activated by modulation of the F0F1-ATPase: implications for selective killing of autoimmune lymphocytes. The Journal of Pharmacology and Experimental Therapeutics. 331: 437-44. PMID 19706792 DOI: 10.1124/Jpet.109.156422  0.802
2009 Düser MG, Zarrabi N, Cipriano DJ, Ernst S, Glick GD, Dunn SD, Börsch M. 36 degrees step size of proton-driven c-ring rotation in FoF1-ATP synthase. The Embo Journal. 28: 2689-96. PMID 19644443 DOI: 10.1038/Emboj.2009.213  0.345
2009 Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW, Glick GD. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochemical Pharmacology. 78: 966-73. PMID 19481066 DOI: 10.1016/J.Bcp.2009.05.025  0.802
2009 Johnson KM, Swenson L, Opipari AW, Reuter R, Zarrabi N, Fierke CA, Börsch M, Glick GD. Mechanistic basis for differential inhibition of the F1Fo-ATPase by aurovertin. Biopolymers. 91: 830-40. PMID 19462418 DOI: 10.1002/Bip.21262  0.62
2008 Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW, Glick GD. Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax. Free Radical Biology & Medicine. 45: 1232-42. PMID 18718527 DOI: 10.1016/J.Freeradbiomed.2008.07.022  0.798
2008 Bhagavathula N, Nerusu KC, Hanosh A, Aslam MN, Sundberg TB, Opipari AW, Johnson K, Kang S, Glick GD, Varani J. 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a benzodiazepine, suppresses keratinocyte proliferation and has antipsoriatic activity in the human skin-severe, combined immunodeficient mouse transplant model. The Journal of Pharmacology and Experimental Therapeutics. 324: 938-47. PMID 18055879 DOI: 10.1124/Jpet.107.130955  0.732
2008 Gatza E, Clouthier S, Rogers C, Reddy P, Opipari A, Glick G, Ferrara J. 25: Benzodiazepine-423, an Inhibitor of Mitochondrial Respiration, Causes Selective Apoptosis of Activated Lymphocytes and Reverses Experimental GVHD While Preserving GVL Effects Biology of Blood and Marrow Transplantation. 14: 12. DOI: 10.1182/Blood.V110.11.68.68  0.341
2007 Bobeck MJ, Rueda D, Walter NG, Glick GD. Structural modeling of sequence specificity by an autoantibody against single-stranded DNA. Biochemistry. 46: 6753-65. PMID 17503778 DOI: 10.1021/Bi700212S  0.794
2007 Bobeck MJ, Glick GD. Role of conformational dynamics in sequence-specific autoantibody*ssDNA recognition. Biopolymers. 85: 481-9. PMID 17252586 DOI: 10.1002/Bip.20692  0.785
2007 Bobeck MJ, Cleary J, Beckingham JA, Ackroyd PC, Glick GD. Effect of somatic mutation on DNA binding properties of anti-DNA autoantibodies. Biopolymers. 85: 471-80. PMID 17252585 DOI: 10.1002/Bip.20691  0.769
2007 Cleary J, Johnson KM, Opipari AW, Glick GD. Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor. Bioorganic & Medicinal Chemistry Letters. 17: 1667-70. PMID 17251020 DOI: 10.1016/J.Bmcl.2006.12.102  0.729
2007 Zarrabi N, Düser MG, Ernst S, Reuter R, Glick GD, Dunn SD, Wrachtrup J, Börsch M. Monitoring the rotary motors of single F0 F1-ATP synthase by synchronized multi channel TCSPC Proceedings of Spie - the International Society For Optical Engineering. 6771. DOI: 10.1117/12.734301  0.339
2006 Johnson KM, Cleary J, Fierke CA, Opipari AW, Glick GD. Mechanistic basis for therapeutic targeting of the mitochondrial F1F0-ATPase. Acs Chemical Biology. 1: 304-8. PMID 17163759 DOI: 10.1021/Cb600143J  0.734
2006 Francis TM, Sundberg TB, Cleary J, Groendyke T, Opipari AW, Glick GD. Identification of cytotoxic, T-cell-selective 1,4-benzodiazepine-2,5-diones. Bioorganic & Medicinal Chemistry Letters. 16: 2423-7. PMID 16488147 DOI: 10.1016/J.Bmcl.2006.01.113  0.788
2006 Sundberg TB, Ney GM, Subramanian C, Opipari AW, Glick GD. The immunomodulatory benzodiazepine Bz-423 inhibits B-cell proliferation by targeting c-myc protein for rapid and specific degradation. Cancer Research. 66: 1775-82. PMID 16452238 DOI: 10.1158/0008-5472.Can-05-3476  0.765
2005 Johnson KM, Chen X, Boitano A, Swenson L, Opipari AW, Glick GD. Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423. Chemistry & Biology. 12: 485-96. PMID 15850986 DOI: 10.1016/J.Chembiol.2005.02.012  0.775
2005 Varani J, Bhagavathula N, Nerusu KC, Sherzer H, Fay K, Boitano AE, Glick GD, Johnson K, Kang S, Opipari AW. A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin. The Journal of Pharmacology and Experimental Therapeutics. 313: 56-63. PMID 15576471 DOI: 10.1124/Jpet.104.075929  0.632
2004 Bednarski JJ, Lyssiotis CA, Roush R, Boitano AE, Glick GD, Opipari AW. A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis. The Journal of Biological Chemistry. 279: 29615-21. PMID 15123639 DOI: 10.1074/Jbc.M403507200  0.762
2003 Boitano A, Ellman JA, Glick GD, Opipari AW. The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells. Cancer Research. 63: 6870-6. PMID 14583485  0.641
2003 Boitano A, Emal CD, Leonetti F, Blatt NB, Dineen TA, Ellman JA, Roush WR, Opipari AW, Glick GD. Structure activity studies of a novel cytotoxic benzodiazepine. Bioorganic & Medicinal Chemistry Letters. 13: 3327-30. PMID 12951119 DOI: 10.1016/S0960-894X(03)00683-8  0.768
2003 Beckingham JA, Cleary J, Bobeck M, Glick GD. Kinetic analysis of sequence-specific recognition of ssDNA by an autoantibody. Biochemistry. 42: 4118-26. PMID 12680766 DOI: 10.1021/Bi020658K  0.783
2003 Bednarski JJ, Warner RE, Rao T, Leonetti F, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW, Glick GD. Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine. Arthritis and Rheumatism. 48: 757-66. PMID 12632430 DOI: 10.1002/Art.10968  0.643
2003 Cleary J, Glick GD. Mutational analysis of a sequence-specific ssDNA binding lupus autoantibody. Biochemistry. 42: 30-41. PMID 12515537 DOI: 10.1021/Bi0203942  0.653
2002 Blatt NB, Bednarski JJ, Warner RE, Leonetti F, Johnson KM, Boitano A, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW, Glick GD. Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. The Journal of Clinical Investigation. 110: 1123-32. PMID 12393848 DOI: 10.1172/Jci16029  0.781
2002 Glick GD, Pompliano DL. Next-generation therapeutics Current Opinion in Chemical Biology. 6: 415-417. DOI: 10.1016/S1367-5931(02)00354-X  0.634
2001 Beckingham JA, Glick GD. Sequence specific recognition of ssDNA by a lupus autoantibody: kinetics and mechanism of binding. Bioorganic & Medicinal Chemistry. 9: 2243-52. PMID 11553462 DOI: 10.1016/S0968-0896(01)00076-1  0.417
2001 Blatt NB, Glick GD. Signaling pathways and effector mechanisms pre-programmed cell death. Bioorganic & Medicinal Chemistry. 9: 1371-84. PMID 11408158 DOI: 10.1016/S0968-0896(01)00041-4  0.718
2001 Ackroyd PC, Cleary J, Glick GD. Thermodynamic basis for sequence-specific recognition of ssDNA by an autoantibody. Biochemistry. 40: 2911-22. PMID 11258903 DOI: 10.1021/Bi0023854  0.803
2001 Pinard R, Lambert D, Heckman JE, Esteban JA, Gundlach CW, Hampel KJ, Glick GD, Walter NG, Major F, Burke JM. The hairpin ribozyme substrate binding-domain: a highly constrained D-shaped conformation. Journal of Molecular Biology. 307: 51-65. PMID 11243803 DOI: 10.1006/Jmbi.2000.4472  0.322
1999 Blatt NB, Glick GD. Anti-DNA autoantibodies and systemic lupus erythematosus. Pharmacology & Therapeutics. 83: 125-39. PMID 10511458 DOI: 10.1016/S0163-7258(99)00022-4  0.716
1999 Stevens SY, Glick GD. Evidence for sequence-specific recognition of DNA by anti-single-stranded DNA autoantibodies. Biochemistry. 38: 560-8. PMID 9888795 DOI: 10.1021/Bi981899O  0.427
1998 Blatt NB, Bill RM, Glick GD. Characterization of a unique anti-DNA hybridoma. Hybridoma. 17: 33-9. PMID 9523235 DOI: 10.1089/Hyb.1998.17.33  0.747
1997 Bill RM, Blatt NB, Glick GD. Anti-DNA autoantibodies: the other DNA-binding proteins. Bioorganic & Medicinal Chemistry. 5: 467-72. PMID 9113324 DOI: 10.1016/S0968-0896(96)00275-1  0.734
1996 Swanson PC, Ackroyd C, Glick GD. Ligand recognition by anti-DNA autoantibodies. Affinity, specificity, and mode of binding. Biochemistry. 35: 1624-33. PMID 8634294 DOI: 10.1021/Bi9516788  0.378
1996 Swanson PC, Yung RL, Blatt NB, Eagan MA, Norris JM, Richardson BC, Johnson KJ, Glick GD. Ligand recognition by murine anti-DNA autoantibodies. II. Genetic analysis and pathogenicity. The Journal of Clinical Investigation. 97: 1748-60. PMID 8601641 DOI: 10.1172/Jci118602  0.745
1995 Cain RJ, Zuiderweg ER, Glick GD. Solution structure of a DNA hairpin and its disulfide cross-linked analog. Nucleic Acids Research. 23: 2153-60. PMID 7610043 DOI: 10.1093/Nar/23.12.2153  0.325
1995 Eagan MA, Norris JM, Cooper BC, Glick GD. Structural Patterns in Anti-DNA Autoantibodies: A Molecular Modeling Study Bioorganic Chemistry. 23: 482-498. DOI: 10.1006/Bioo.1995.1034  0.39
1994 Stevens SY, Swanson PC, Glick GD. Application of the gel shift assay to study the affinity and specificity of anti-DNA autoantibodies. Journal of Immunological Methods. 177: 185-90. PMID 7822825 DOI: 10.1016/0022-1759(94)90155-4  0.346
1994 Goodwin JT, Osborne SE, Swanson PC, Glick GD. Synthesis of a disulfide cross-linked DNA triple helix Tetrahedron Letters. 35: 4527-4530. DOI: 10.1016/S0040-4039(00)60718-9  0.3
1993 Blatt NB, Osborne SE, Cain RJ, Glick GD. Conformational studies of hairpin sequences from the ColE1 cruciform. Biochimie. 75: 433-41. PMID 8364093 DOI: 10.1016/0300-9084(93)90108-5  0.702
1993 Swanson PC, Glick GD. Chemical sequencing of disulfide-crosslinked oligodeoxyribonucleotides Bioorganic and Medicinal Chemistry Letters. 3: 2117-2118. DOI: 10.1016/S0960-894X(01)81028-3  0.341
1992 Sauter NK, Glick GD, Crowther RL, Park SJ, Eisen MB, Skehel JJ, Knowles JR, Wiley DC. Crystallographic detection of a second ligand binding site in influenza virus hemagglutinin. Proceedings of the National Academy of Sciences of the United States of America. 89: 324-8. PMID 1729702 DOI: 10.1073/Pnas.89.1.324  0.508
1992 Loganathan D, Osborne SE, Glick GD, Goldstein IJ. Synthesis of high-affinity, hydrophobic monosaccharide derivatives and study of their interaction with concanavalin A, the pea, the lentil, and fava bean lectins. Archives of Biochemistry and Biophysics. 299: 268-74. PMID 1444465 DOI: 10.1016/0003-9861(92)90274-Z  0.314
1992 Sauter NK, Hanson JE, Glick GD, Brown JH, Crowther RL, Park SJ, Skehel JJ, Wiley DC. Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography. Biochemistry. 31: 9609-21. PMID 1327122 DOI: 10.1021/Bi00155A013  0.3
1991 Toogood PL, Galliker PK, Glick GD, Knowles JR. Monovalent sialosides that bind tightly to influenza A virus. Journal of Medicinal Chemistry. 34: 3138-40. PMID 1920363 DOI: 10.1021/Jm00114A025  0.494
1991 Glick GD, Toogood PL, Wiley DC, Skehel JJ, Knowles JR. Ligand recognition by influenza virus. The binding of bivalent sialosides. The Journal of Biological Chemistry. 266: 23660-9. PMID 1748643  0.486
1991 Glick GD, Knowles JR. Molecular Recognition of Bivalent Sialosides by Influenza Virus Journal of the American Chemical Society. 113: 4701-4703. DOI: 10.1021/Ja00012A060  0.461
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