| Year |
Citation |
Score |
| 2016 |
Schmidt K, Keiser S, Günther V, Georgiev O, Hirsch HH, Schaffner W, Bethge T. Transcription enhancers as major determinants of SV40 polyomavirus growth efficiency and host cell tropism. The Journal of General Virology. 97: 1597-603. PMID 27100458 DOI: 10.1099/Jgv.0.000487 |
0.465 |
|
| 2016 |
Schmidt K, Steiner K, Petrov B, Georgiev O, Schaffner W. Short-lived mammals (shrew, mouse) have a less robust metal-responsive transcription factor than humans and bats. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 29: 423-32. PMID 27067444 DOI: 10.1007/S10534-016-9926-4 |
0.41 |
|
| 2015 |
Schaffner W. Enhancers, enhancers - from their discovery to today's universe of transcription enhancers. Biological Chemistry. 396: 311-27. PMID 25719310 DOI: 10.1515/Hsz-2014-0303 |
0.5 |
|
| 2015 |
Bethge T, Hachemi HA, Manzetti J, Gosert R, Schaffner W, Hirsch HH. Sp1 sites in the noncoding control region of BK polyomavirus are key regulators of bidirectional viral early and late gene expression. Journal of Virology. 89: 3396-411. PMID 25589646 DOI: 10.1128/Jvi.03625-14 |
0.392 |
|
| 2015 |
Keiser S, Schmidt K, Bethge T, Steiger J, Hirsch HH, Schaffner W, Georgiev O. Emergence of infectious simian virus 40 whose AT tract in the replication origin/early promoter region is substituted by cellular or viral DNAs. The Journal of General Virology. 96: 601-6. PMID 25385869 DOI: 10.1099/Vir.0.071274-0 |
0.359 |
|
| 2014 |
Georgiev O, Günther V, Steiner K, Schönrath K, Schaffner W. The legless lizard Anguis fragilis (slow worm) has a potent metal-responsive transcription factor 1 (MTF-1). Biological Chemistry. 395: 425-31. PMID 24413216 DOI: 10.1515/Hsz-2013-0293 |
0.377 |
|
| 2013 |
Maricic T, Günther V, Georgiev O, Gehre S, Curlin M, Schreiweis C, Naumann R, Burbano HA, Meyer M, Lalueza-Fox C, de la Rasilla M, Rosas A, Gajovic S, Kelso J, Enard W, ... Schaffner W, et al. A recent evolutionary change affects a regulatory element in the human FOXP2 gene. Molecular Biology and Evolution. 30: 844-52. PMID 23197593 DOI: 10.1093/Molbev/Mss271 |
0.446 |
|
| 2012 |
Atanesyan L, Günther V, Dichtl B, Georgiev O, Schaffner W. Polyglutamine tracts as modulators of transcriptional activation from yeast to mammals. Biological Chemistry. 393: 63-70. PMID 22628299 DOI: 10.1515/Bc-2011-252 |
0.444 |
|
| 2012 |
Günther V, Lindert U, Schaffner W. The taste of heavy metals: gene regulation by MTF-1. Biochimica Et Biophysica Acta. 1823: 1416-25. PMID 22289350 DOI: 10.1016/J.Bbamcr.2012.01.005 |
0.432 |
|
| 2012 |
Günther V, Strassen T, Lindert U, Dagani P, Waldvogel D, Georgiev O, Schaffner W, Bethge T. Simian virus 40 strains with novel properties generated by replacing the viral enhancer with synthetic oligonucleotides. Journal of Virology. 86: 3135-42. PMID 22238322 DOI: 10.1128/Jvi.06293-11 |
0.482 |
|
| 2012 |
Günther V, Waldvogel D, Nosswitz M, Georgiev O, Schaffner W. Dissection of Drosophila MTF-1 reveals a domain for differential target gene activation upon copper overload vs. copper starvation. The International Journal of Biochemistry & Cell Biology. 44: 404-11. PMID 22138226 DOI: 10.1016/J.Biocel.2011.11.016 |
0.48 |
|
| 2012 |
Günther V, Davis AM, Georgiev O, Schaffner W. A conserved cysteine cluster, essential for transcriptional activity, mediates homodimerization of human metal-responsive transcription factor-1 (MTF-1). Biochimica Et Biophysica Acta. 1823: 476-83. PMID 22057392 DOI: 10.1016/J.Bbamcr.2011.10.006 |
0.509 |
|
| 2011 |
Atanesyan L, Günther V, Celniker SE, Georgiev O, Schaffner W. Characterization of MtnE, the fifth metallothionein member in Drosophila. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 16: 1047-56. PMID 21870250 DOI: 10.1007/S00775-011-0825-4 |
0.469 |
|
| 2011 |
Hua H, Münter L, Harmeier A, Georgiev O, Multhaup G, Schaffner W. Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability. Biological Chemistry. 392: 919-26. PMID 21801085 DOI: 10.1515/Bc.2011.084 |
0.312 |
|
| 2011 |
Hua H, Günther V, Georgiev O, Schaffner W. Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 24: 445-53. PMID 21465178 DOI: 10.1007/S10534-011-9438-1 |
0.305 |
|
| 2011 |
Saini N, Georgiev O, Schaffner W. The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1). Molecular and Cellular Biology. 31: 2151-61. PMID 21383066 DOI: 10.1128/Mcb.05207-11 |
0.388 |
|
| 2010 |
Saini N, Oelhafen S, Hua H, Georgiev O, Schaffner W, Büeler H. Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways. Neurobiology of Disease. 40: 82-92. PMID 20483372 DOI: 10.1016/J.Nbd.2010.05.011 |
0.312 |
|
| 2010 |
Steiger D, Fetchko M, Vardanyan A, Atanesyan L, Steiner K, Turski ML, Thiele DJ, Georgiev O, Schaffner W. The Drosophila copper transporter Ctr1C functions in male fertility. The Journal of Biological Chemistry. 285: 17089-97. PMID 20351114 DOI: 10.1074/Jbc.M109.090282 |
0.318 |
|
| 2010 |
Saini N, Schaffner W. Zinc supplement greatly improves the condition of parkin mutant Drosophila. Biological Chemistry. 391: 513-8. PMID 20302514 DOI: 10.1515/Bc.2010.052 |
0.344 |
|
| 2010 |
Hua H, Georgiev O, Schaffner W, Steiger D. Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 107-13. PMID 19856191 DOI: 10.1007/S00775-009-0599-0 |
0.336 |
|
| 2009 |
Lindert U, Cramer M, Meuli M, Georgiev O, Schaffner W. Metal-responsive transcription factor 1 (MTF-1) activity is regulated by a nonconventional nuclear localization signal and a metal-responsive transactivation domain. Molecular and Cellular Biology. 29: 6283-93. PMID 19797083 DOI: 10.1128/Mcb.00847-09 |
0.465 |
|
| 2009 |
Balamurugan K, Hua H, Georgiev O, Schaffner W. Mercury and cadmium trigger expression of the copper importer Ctr1B, which enables Drosophila to thrive on heavy metal-loaded food. Biological Chemistry. 390: 109-13. PMID 19040355 DOI: 10.1515/Bc.2009.020 |
0.47 |
|
| 2008 |
Kappeler M, Kranz E, Woolcock K, Georgiev O, Schaffner W. Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences Nucleic Acids Research. 36: 6907-6917. PMID 18978019 DOI: 10.1093/Nar/Gkn793 |
0.411 |
|
| 2008 |
Lindert U, Leuzinger L, Steiner K, Georgiev O, Schaffner W. Characterization of metal-responsive transcription factor (MTF-1) from the giant rodent capybara reveals features in common with human as well as with small rodents (mouse, rat). Short communication. Chemistry & Biodiversity. 5: 1485-94. PMID 18729110 DOI: 10.1002/Cbdv.200890137 |
0.402 |
|
| 2008 |
Vardanyan A, Atanesyan L, Egli D, Raja SJ, Steinmann-Zwicky M, Renkawitz-Pohl R, Georgiev O, Schaffner W. Dumpy-30 family members as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. Bmc Developmental Biology. 8: 68. PMID 18588663 DOI: 10.1186/1471-213X-8-68 |
0.653 |
|
| 2007 |
Balamurugan K, Egli D, Hua H, Rajaram R, Seisenbacher G, Georgiev O, Schaffner W. Copper homeostasis in Drosophila by complex interplay of import, storage and behavioral avoidance Embo Journal. 26: 1035-1044. PMID 17290228 DOI: 10.1038/Sj.Emboj.7601543 |
0.6 |
|
| 2007 |
Takeuchi H, Georgiev O, Fetchko M, Kappeler M, Schaffner W, Egli D. In vivo construction of transgenes in Drosophila. Genetics. 175: 2019-28. PMID 17179096 DOI: 10.1534/Genetics.106.065920 |
0.634 |
|
| 2006 |
Yepiskoposyan H, Egli D, Fergestad T, Selvaraj A, Treiber C, Multhaup G, Georgiev O, Schaffner W. Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc. Nucleic Acids Research. 34: 4866-77. PMID 16973896 DOI: 10.1093/Nar/Gkl606 |
0.665 |
|
| 2006 |
Balamurugan K, Schaffner W. Copper homeostasis in eukaryotes: teetering on a tightrope. Biochimica Et Biophysica Acta. 1763: 737-46. PMID 16784785 DOI: 10.1016/J.Bbamcr.2006.05.001 |
0.367 |
|
| 2006 |
Egli D, Domènech J, Selvaraj A, Balamurugan K, Hua H, Capdevila M, Georgiev O, Schaffner W, Atrian S. The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 11: 647-58. PMID 16716195 DOI: 10.1111/J.1365-2443.2006.00971.X |
0.657 |
|
| 2006 |
Egli D, Yepiskoposyan H, Selvaraj A, Balamurugan K, Rajaram R, Simons A, Multhaup G, Mettler S, Vardanyan A, Georgiev O, Schaffner W. A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. Molecular and Cellular Biology. 26: 2286-96. PMID 16508004 DOI: 10.1128/Mcb.26.6.2286-2296.2006 |
0.665 |
|
| 2005 |
Wimmer U, Wang Y, Georgiev O, Schaffner W. Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione. Nucleic Acids Research. 33: 5715-27. PMID 16221973 DOI: 10.1093/Nar/Gki881 |
0.468 |
|
| 2005 |
Cramer M, Nagy I, Murphy BJ, Gassmann M, Hottiger MO, Georgiev O, Schaffner W. NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Biological Chemistry. 386: 865-72. PMID 16164411 DOI: 10.1515/Bc.2005.101 |
0.397 |
|
| 2005 |
Petrascheck M, Escher D, Mahmoudi T, Verrijzer CP, Schaffner W, Barberis A. DNA looping induced by a transcriptional enhancer in vivo. Nucleic Acids Research. 33: 3743-50. PMID 16002789 DOI: 10.1093/Nar/Gki689 |
0.5 |
|
| 2005 |
Selvaraj A, Balamurugan K, Yepiskoposyan H, Zhou H, Egli D, Georgiev O, Thiele DJ, Schaffner W. Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Genes & Development. 19: 891-6. PMID 15833915 DOI: 10.1101/Gad.1301805 |
0.701 |
|
| 2005 |
Tamura Y, Maruyama M, Mishima Y, Fujisawa H, Obata M, Kodama Y, Yoshikai Y, Aoyagi Y, Niwa O, Schaffner W, Kominami R. Predisposition to mouse thymic lymphomas in response to ionizing radiation depends on variant alleles encoding metal-responsive transcription factor-1 (Mtf-1). Oncogene. 24: 399-406. PMID 15516976 DOI: 10.1038/Sj.Onc.1208197 |
0.386 |
|
| 2004 |
Wang Y, Lorenzi I, Georgiev O, Schaffner W. Metal-responsive transcription factor-1 (MTF-1) selects different types of metal response elements at low vs. high zinc concentration. Biological Chemistry. 385: 623-32. PMID 15318811 DOI: 10.1515/Bc.2004.077 |
0.474 |
|
| 2004 |
Balamurugan K, Egli D, Selvaraj A, Zhang B, Georgiev O, Schaffner W. Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison. Biological Chemistry. 385: 597-603. PMID 15318808 DOI: 10.1515/Bc.2004.074 |
0.684 |
|
| 2004 |
Haroon ZA, Amin K, Lichtlen P, Sato B, Huynh NT, Wang Z, Schaffner W, Murphy BJ. Loss of metal transcription factor-1 suppresses tumor growth through enhanced matrix deposition. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1176-84. PMID 15284217 DOI: 10.1096/Fj.03-1205Com |
0.306 |
|
| 2004 |
Wang Y, Wimmer U, Lichtlen P, Inderbitzin D, Stieger B, Meier PJ, Hunziker L, Stallmach T, Forrer R, Rülicke T, Georgiev O, Schaffner W. Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1071-9. PMID 15226267 DOI: 10.1096/Fj.03-1282Com |
0.381 |
|
| 2004 |
Egli D, Hafen E, Schaffner W. An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster. Genome Research. 14: 1382-93. PMID 15197166 DOI: 10.1101/Gr.2279804 |
0.608 |
|
| 2004 |
Chen X, Zhang B, Harmon PM, Schaffner W, Peterson DO, Giedroc DP. A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo. The Journal of Biological Chemistry. 279: 4515-22. PMID 14610091 DOI: 10.1074/Jbc.M308924200 |
0.499 |
|
| 2004 |
Schaffner W, Egli D, Kuppusamy B, Yepiskoposyan H, Selvaraj A, Nagy I, Wang Y, Zhang B, Georgiev O. Heavy metal stress response from insects to mammals Gbm Annual Spring Meeting Mosbach 2004. 2004. DOI: 10.1240/sav_gbm_2004_m_000461 |
0.543 |
|
| 2003 |
Zhang B, Georgiev O, Hagmann M, Günes C, Cramer M, Faller P, Vasák M, Schaffner W. Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein. Molecular and Cellular Biology. 23: 8471-85. PMID 14612393 DOI: 10.1128/Mcb.23.23.8471-8485.2003 |
0.502 |
|
| 2003 |
Saydam N, Steiner F, Georgiev O, Schaffner W. Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1. The Journal of Biological Chemistry. 278: 31879-83. PMID 12805380 DOI: 10.1074/Jbc.M302138200 |
0.395 |
|
| 2003 |
Peter I, Graf C, Dummer R, Schaffner W, Greber UF, Hemmi S. A novel attenuated replication-competent adenovirus for melanoma therapy. Gene Therapy. 10: 530-9. PMID 12646858 DOI: 10.1038/Sj.Gt.3301940 |
0.341 |
|
| 2003 |
Egli D, Selvaraj A, Yepiskoposyan H, Zhang B, Hafen E, Georgiev O, Schaffner W. Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. The Embo Journal. 22: 100-8. PMID 12505988 DOI: 10.1093/Emboj/Cdg012 |
0.675 |
|
| 2002 |
Adams TK, Saydam N, Steiner F, Schaffner W, Freedman JH. Activation of gene expression by metal-responsive signal transduction pathways. Environmental Health Perspectives. 110: 813-7. PMID 12426137 DOI: 10.1289/Ehp.02110S5813 |
0.44 |
|
| 2002 |
Stamminger T, Gstaiger M, Weinzierl K, Lorz K, Winkler M, Schaffner W. Open reading frame UL26 of human cytomegalovirus encodes a novel tegument protein that contains a strong transcriptional activation domain. Journal of Virology. 76: 4836-47. PMID 11967300 DOI: 10.1128/Jvi.76.10.4836-4847.2002 |
0.477 |
|
| 2002 |
Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH. Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription. The Journal of Biological Chemistry. 277: 20438-45. PMID 11923282 DOI: 10.1074/Jbc.M110631200 |
0.454 |
|
| 2002 |
Lichtlen P, Schaffner W. Putting its fingers on stressful situations: the heavy metal-regulatory transcription factor MTF-1. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 23: 1010-7. PMID 11746217 DOI: 10.1002/Bies.1146 |
0.424 |
|
| 2001 |
Zhang B, Egli D, Georgiev O, Schaffner W. The Drosophila homolog of mammalian zinc finger factor MTF-1 activates transcription in response to heavy metals. Molecular and Cellular Biology. 21: 4505-14. PMID 11416130 DOI: 10.1128/Mcb.21.14.4505-4514.2001 |
0.688 |
|
| 2001 |
Saydam N, Georgiev O, Nakano MY, Greber UF, Schaffner W. Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals. The Journal of Biological Chemistry. 276: 25487-95. PMID 11306562 DOI: 10.1074/Jbc.M009154200 |
0.468 |
|
| 2001 |
Lichtlen P, Wang Y, Belser T, Georgiev O, Certa U, Sack R, Schaffner W. Target gene search for the metal-responsive transcription factor MTF-1. Nucleic Acids Research. 29: 1514-23. PMID 11266553 DOI: 10.1093/Nar/29.7.1514 |
0.442 |
|
| 2001 |
Andrews GK, Lee DK, Ravindra R, Lichtlen P, Sirito M, Sawadogo M, Schaffner W. The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development. The Embo Journal. 20: 1114-22. PMID 11230134 DOI: 10.1093/Emboj/20.5.1114 |
0.469 |
|
| 2001 |
Auf der Maur A, Belser T, Wang Y, Günes C, Lichtlen P, Georgiev O, Schaffner W. Characterization of the mouse gene for the heavy metal-responsive transcription factor MTF-1. Cell Stress & Chaperones. 5: 196-206. PMID 11005378 DOI: 10.1379/1466-1268(2000)005<0196:Cotmgf>2.0.Co;2 |
0.486 |
|
| 2001 |
Lichtlen P, Schaffner W. The "metal transcription factor" MTF-1: biological facts and medical implications Swiss Medical Weekly. 131: 647-652. DOI: 10.4414/Smw.2001.09672 |
0.39 |
|
| 2000 |
Escher D, Bodmer-Glavas M, Barberis A, Schaffner W. Conservation of glutamine-rich transactivation function between yeast and humans. Molecular and Cellular Biology. 20: 2774-82. PMID 10733580 DOI: 10.1128/Mcb.20.8.2774-2782.2000 |
0.404 |
|
| 1999 |
Lichtlen P, Georgiev O, Schaffner W, Aguzzi A, Brandner S. The heavy metal-responsive transcription factor-1 (MTF-1) is not required for neural differentiation. Biological Chemistry. 380: 711-5. PMID 10430037 DOI: 10.1515/Bc.1999.089 |
0.346 |
|
| 1999 |
Auf der Maur A, Belser T, Elgar G, Georgiev O, Schaffner W. Characterization of the transcription factor MTF-1 from the Japanese pufferfish (Fugu rubripes) reveals evolutionary conservation of heavy metal stress response. Biological Chemistry. 380: 175-85. PMID 10195425 DOI: 10.1515/Bc.1999.026 |
0.548 |
|
| 1999 |
Schaffner W, Clay OK, Ahmed S. Proto-oncogenes, unlike 'harmless' genes, tend to be dispersed in the human genome: selection against out-of-register recombination? Biological Chemistry. 380: 3-5. PMID 10064131 DOI: 10.1515/Bc.1999.001 |
0.314 |
|
| 1998 |
Hagmann M, Bruggmann R, Xue L, Georgiev O, Schaffner W, Rungger D, Spaniol P, Gerster T. Homologous recombination and DNA-end joining reactions in zygotes and early embryos of zebrafish (Danio rerio) and Drosophila melanogaster. Biological Chemistry. 379: 673-81. PMID 9687016 DOI: 10.1515/Bchm.1998.379.6.673 |
0.409 |
|
| 1998 |
Günes C, Heuchel R, Georgiev O, Müller KH, Lichtlen P, Blüthmann H, Marino S, Aguzzi A, Schaffner W. Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. The Embo Journal. 17: 2846-54. PMID 9582278 DOI: 10.1093/Emboj/17.10.2846 |
0.426 |
|
| 1998 |
Rother KI, Clay OK, Bourquin JP, Silke J, Schaffner W. Long non-stop reading frames on the antisense strand of heat shock protein 70 genes and prion protein (PrP) genes are conserved between species. Biological Chemistry. 378: 1521-30. PMID 9461351 DOI: 10.1515/Bchm.1997.378.12.1521 |
0.371 |
|
| 1998 |
Escher D, Schaffner W. Gene activation at a distance and telomeric silencing are not affected by yeast histone H1. Molecular & General Genetics : Mgg. 256: 456-61. PMID 9393443 DOI: 10.1007/S004380050589 |
0.426 |
|
| 1998 |
Moosmann P, Georgiev O, Thiesen HJ, Hagmann M, Schaffner W. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor. Biological Chemistry. 378: 669-77. PMID 9278146 DOI: 10.1515/Bchm.1997.378.7.669 |
0.435 |
|
| 1997 |
Tanner S, Stagljar I, Georgiev O, Schaffner W, Bourquin JP. A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain. Biological Chemistry. 378: 565-71. PMID 9224939 DOI: 10.1515/Bchm.1997.378.6.565 |
0.387 |
|
| 1997 |
Hagmann M, Georgiev O, Schaffner W. The VP16 paradox: herpes simplex virus VP16 contains a long-range activation domain but within the natural multiprotein complex activates only from promoter-proximal positions. Journal of Virology. 71: 5952-62. PMID 9223485 DOI: 10.1128/Jvi.71.8.5952-5962.1997 |
0.452 |
|
| 1997 |
Bourquin JP, Stagljar I, Meier P, Moosmann P, Silke J, Baechi T, Georgiev O, Schaffner W. A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II Nucleic Acids Research. 25: 2055-2061. PMID 9153302 DOI: 10.1093/Nar/25.11.2055 |
0.356 |
|
| 1997 |
Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W. Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1. Nucleic Acids Research. 24: 4859-67. PMID 9016654 DOI: 10.1093/Nar/24.24.4859 |
0.389 |
|
| 1997 |
Escher D, Schaffner W. Improved "activator trap" method for the isolation of transcriptional activation domains from random DNA fragments. Biotechniques. 21: 848-54. PMID 8922625 DOI: 10.2144/96215St02 |
0.445 |
|
| 1997 |
Stagljar I, Bourquin JP, Schaffner W. Use of the two-hybrid system and random sonicated DNA to identify the interaction domain of a protein. Biotechniques. 21: 430-2. PMID 8879581 DOI: 10.2144/96213Bm20 |
0.35 |
|
| 1997 |
Hagmann M, Adlkofer K, Pfeiffer P, Bruggmann R, Georgiev O, Rungger D, Schaffner W. Dramatic changes in the ratio of homologous recombination to nonhomologous DNA-end joining in oocytes and early embryos of Xenopus laevis. Biological Chemistry Hoppe-Seyler. 377: 239-50. PMID 8737989 DOI: 10.1515/Bchm3.1996.377.4.239 |
0.386 |
|
| 1996 |
Radtke F, Hug M, Georgiev O, Matsuo K, Schaffner W. Differential sensitivity of zinc finger transcription factors MTF-1, Sp1 and Krox-20 to CpG methylation of their binding sites. Biological Chemistry Hoppe-Seyler. 377: 47-56. PMID 8929813 DOI: 10.1515/Bchm3.1996.377.1.47 |
0.422 |
|
| 1996 |
Knoepfel L, Georgiev O, Nielsen P, Schaffner W. Cloning and Characterization of the Murine B-Cell Specific Transcriptional Coactivator Bob1 Biological Chemistry Hoppe-Seyler. 377: 139-146. PMID 8868069 DOI: 10.1515/Bchm3.1996.377.2.139 |
0.356 |
|
| 1996 |
Rother KI, Silke J, Georgiev O, Schaffner W, Matsuo K. Influence of DNA sequence and methylation status on bisulfite conversion of cytosine residues. Analytical Biochemistry. 231: 263-5. PMID 8678311 DOI: 10.1006/Abio.1995.1530 |
0.347 |
|
| 1996 |
Georgiev O, Bourquin JP, Gstaiger M, Knoepfel L, Schaffner W, Hovens C. Two versatile eukaryotic vectors permitting epitope tagging, radiolabelling and nuclear localisation of expressed proteins. Gene. 168: 165-7. PMID 8654937 DOI: 10.1016/0378-1119(95)00764-4 |
0.363 |
|
| 1996 |
Müller HP, Brungnera E, Georgiev O, Badzong M, Müller KH, Schaffner W. Analysis of the heavy metal-responsive transcription factor MTF-1 from human and mouse. Somatic Cell and Molecular Genetics. 21: 289-97. PMID 8619126 DOI: 10.1007/Bf02257464 |
0.449 |
|
| 1996 |
Hagmann M, Georgiev O, Schaffner W, Douville P. Transcription factors interacting with herpes simplex virus alpha gene promoters in sensory neurons. Nucleic Acids Research. 23: 4978-85. PMID 8559654 DOI: 10.1093/Nar/23.24.4978 |
0.374 |
|
| 1996 |
Gstaiger M, Georgiev O, van Leeuwen H, van der Vliet P, Schaffner W. The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation. The Embo Journal. 15: 2781-2790. DOI: 10.1002/J.1460-2075.1996.Tb00638.X |
0.484 |
|
| 1995 |
Matsuo K, Clay O, Künzler P, Georgiev O, Urbánek P, Schaffner W. Short introns interrupting the Oct-2 POU domain may prevent recombination between POU family genes without interfering with potential POU domain 'shuffling' in evolution. Biological Chemistry Hoppe-Seyler. 375: 675-83. PMID 7888080 DOI: 10.1515/Bchm3.1994.375.10.675 |
0.401 |
|
| 1995 |
Douville P, Hagmann M, Georgiev O, Schaffner W. Positive and negative regulation at the herpes simplex virus ICP4 and ICP0 TAATGARAT motifs. Virology. 207: 107-16. PMID 7871718 DOI: 10.1006/Viro.1995.1056 |
0.446 |
|
| 1995 |
Matsuo K, Silke J, Gramatikoff K, Schaffner W. The CpG-specific methylase SssI has topoisomerase activity in the presence of Mg2+. Nucleic Acids Research. 22: 5354-9. PMID 7816625 DOI: 10.1093/Nar/22.24.5354 |
0.335 |
|
| 1995 |
Hergersberg M, Matsuo K, Gassmann M, Schaffner W, Lüscher B, Rülicke T, Aguzzi A. Tissue-specific expression of a FMR1/beta-galactosidase fusion gene in transgenic mice. Human Molecular Genetics. 4: 359-66. PMID 7795588 DOI: 10.1093/Hmg/4.3.359 |
0.627 |
|
| 1995 |
Gstaiger M, Knoepfel L, Georgiev O, Schaffner W, Hovens CM. A B-cell coactivator of octamer-binding transcription factors. Nature. 373: 360-2. PMID 7779176 DOI: 10.1038/373360A0 |
0.436 |
|
| 1995 |
Gerber HP, Hagmann M, Seipel K, Georgiev O, West MA, Litingtung Y, Schaffner W, Corden JL. RNA polymerase II C-terminal domain required for enhancer-driven transcription. Nature. 374: 660-2. PMID 7715709 DOI: 10.1038/374660A0 |
0.429 |
|
| 1995 |
Gramatikoff K, Schaffner W, Georgiev O. The leucine zipper of c-Jun binds to ribosomal protein L18a: a role in Jun protein regulation? Biological Chemistry Hoppe-Seyler. 376: 321-5. PMID 7662174 DOI: 10.1515/Bchm3.1995.376.5.321 |
0.333 |
|
| 1995 |
Silke J, Rother KI, Georgiev O, Schaffner W, Matsuo K. Complex demethylation patterns at Sp1 binding sites in F9 embryonal carcinoma cells. Febs Letters. 370: 170-4. PMID 7656970 DOI: 10.1016/0014-5793(95)00830-3 |
0.363 |
|
| 1995 |
Künzler P, Matsuo K, Schaffner W. Pathological, physiological, and evolutionary aspects of short unstable DNA repeats in the human genome. Biological Chemistry Hoppe-Seyler. 376: 201-11. PMID 7626229 DOI: 10.1515/Bchm3.1995.376.4.201 |
0.437 |
|
| 1995 |
Radtke F, Georgiev O, Müller HP, Brugnera E, Schaffner W. Functional domains of the heavy metal-responsive transcription regulator MTF-1. Nucleic Acids Research. 23: 2277-86. PMID 7610056 DOI: 10.1093/Nar/23.12.2277 |
0.494 |
|
| 1995 |
Clay O, Schaffner W, Matsuo K. Periodicity of eight nucleotides in purine distribution around human genomic CpG dinucleotides. Somatic Cell and Molecular Genetics. 21: 91-8. PMID 7570188 DOI: 10.1007/Bf02255784 |
0.315 |
|
| 1994 |
Gerber HP, Seipel K, Georgiev O, Höfferer M, Hug M, Rusconi S, Schaffner W. Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science (New York, N.Y.). 263: 808-11. PMID 8303297 DOI: 10.1126/Science.8303297 |
0.455 |
|
| 1994 |
Seipel K, Georgiev O, Gerber HP, Schaffner W. C-terminal domain (CTD) of RNA-polymerase II and N-terminal segment of the human TATA binding protein (TBP) can mediate remote and proximal transcriptional activation, respectively. Nucleic Acids Research. 21: 5609-15. PMID 8284205 DOI: 10.1093/Nar/21.24.5609 |
0.417 |
|
| 1994 |
Handt O, Richards M, Trommsdorff M, Kilger C, Simanainen J, Georgiev O, Bauer K, Stone A, Hedges R, Schaffner W. Molecular genetic analyses of the Tyrolean Ice Man. Science (New York, N.Y.). 264: 1775-8. PMID 8209259 DOI: 10.1126/Science.8209259 |
0.325 |
|
| 1994 |
Xu L, Rungger D, Georgiev O, Seipel K, Schaffner W. Different potential of cellular and viral activators of transcription revealed in oocytes and early embryos of Xenopus laevis. Biological Chemistry Hoppe-Seyler. 375: 105-12. PMID 8192855 DOI: 10.1515/Bchm3.1994.375.2.105 |
0.454 |
|
| 1994 |
Matsuo K, Clay O, Takahashi T, Silke J, Schaffner W. Evidence for erosion of mouse CpG islands during mammalian evolution. Somatic Cell and Molecular Genetics. 19: 543-55. PMID 8128314 DOI: 10.1007/Bf01233381 |
0.411 |
|
| 1994 |
Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W. Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. Nucleic Acids Research. 22: 3167-73. PMID 8065932 DOI: 10.1093/Nar/22.15.3167 |
0.474 |
|
| 1994 |
Seipel K, Georgiev O, Schaffner W. A minimal transcription activation domain consisting of a specific array of aspartic acid and leucine residues. Biological Chemistry Hoppe-Seyler. 375: 463-70. PMID 7945996 DOI: 10.1515/Bchm3.1994.375.7.463 |
0.373 |
|
| 1994 |
Gstaiger M, Schaffner W. Strong transcriptional activators isolated from viral DNA by the 'activator trap', a novel selection system in mammalian cells. Nucleic Acids Research. 22: 4031-8. PMID 7937127 DOI: 10.1093/Nar/22.20.4031 |
0.462 |
|
| 1994 |
Heuchel R, Radtke F, Georgiev O, Stark G, Aguet M, Schaffner W. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. The Embo Journal. 13: 2870-2875. DOI: 10.1002/J.1460-2075.1994.Tb06581.X |
0.548 |
|
| 1994 |
Künzler M, Braus G, Georgiev O, Seipel K, Schaffner W. Functional differences between mammalian transcription activation domains at the yeast GAL1 promoter. The Embo Journal. 13: 641-645. DOI: 10.1002/J.1460-2075.1994.Tb06302.X |
0.435 |
|
| 1993 |
Rigoni P, Xu L, Harshman K, Schaffner W, Arnosti DN. Conserved cysteine residues of Oct-2 POU domain confer sensitivity to oxidation but are dispensable for sequence-specific DNA binding. Biochimica Et Biophysica Acta. 1173: 141-6. PMID 8504164 DOI: 10.1016/0167-4781(93)90174-C |
0.675 |
|
| 1993 |
Schreiber E, Tobler A, Malipiero U, Schaffner W, Fontana A. CDNA cloning of human N-Oct 3, a nervous-system specific POD domain transcription factor binding to the octamer DMA motif Nucleic Acids Research. 21: 253-258. PMID 8441633 DOI: 10.1093/Nar/21.2.253 |
0.437 |
|
| 1993 |
Arnosti DN, Merino A, Reinberg D, Schaffner W. Oct-2 facilitates functional preinitiation complex assembly and is continuously required at the promoter for multiple rounds of transcription. The Embo Journal. 12: 157-66. PMID 8428575 |
0.666 |
|
| 1993 |
Xu L, Schaffner W, Rungger D. Transcriptional activation by recombinant GAL4-VP16 in the Xenopus oocyte. Nucleic Acids Research. 21: 2775. PMID 8332481 DOI: 10.1093/Nar/21.11.2775 |
0.401 |
|
| 1993 |
Arnosti DN, Preston CM, Hagmann M, Schaffner W, Hope RG, Laughlan G, Luisi BF. Specific transcriptional activation in vitro by the herpes simplex virus protein VP16. Nucleic Acids Research. 21: 5570-6. PMID 8284200 DOI: 10.1093/Nar/21.24.5570 |
0.714 |
|
| 1993 |
Gerber HP, Georgiev O, Harshman K, Schaffner W. In vitro transcription complementation assay with miniextracts of transiently transfected COS-1 cells. Nucleic Acids Research. 20: 5855-6. PMID 1454555 DOI: 10.1093/Nar/20.21.5855 |
0.34 |
|
| 1993 |
Radtke F, Heuchel R, Georgiev O, Hergersberg M, Gariglio M, Dembic Z, Schaffner W. Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter. The Embo Journal. 12: 1355-1362. DOI: 10.1002/J.1460-2075.1993.Tb05780.X |
0.545 |
|
| 1993 |
Arnosti D, Merino A, Reinberg D, Schaffner W. Oct-2 facilitates functional preinitiation complex assembly and is continuously required at the promoter for multiple rounds of transcription. The Embo Journal. 12: 157-166. DOI: 10.1002/J.1460-2075.1993.Tb05641.X |
0.692 |
|
| 1992 |
Xu LC, Thali M, Schaffner W. Upstream box/TATA box order is the major determinant of the direction of transcription. Nucleic Acids Research. 19: 6699-704. PMID 1762900 DOI: 10.1093/Nar/19.24.6699 |
0.453 |
|
| 1992 |
Czank A, Häuselmann R, Page AW, Leonhardt H, Bestor TH, Schaffner W, Hergersberg M. Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase. Gene. 109: 259-63. PMID 1662657 DOI: 10.1016/0378-1119(91)90618-L |
0.462 |
|
| 1992 |
Brugnera E, Xu L, Schaffner W, Arnosti DN. POU-specific domain of Oct-2 factor confers 'octamer' motif DNA binding specificity on heterologous Antennapedia homeodomain. Febs Letters. 314: 361-5. PMID 1361457 DOI: 10.1016/0014-5793(92)81506-H |
0.671 |
|
| 1992 |
Seipel K, Georgiev O, Schaffner W. Different activation domains stimulate transcription from remote (‘enhancer’) and proximal (‘promoter’) positions. The Embo Journal. 11: 4961-4968. DOI: 10.1002/J.1460-2075.1992.Tb05603.X |
0.391 |
|
| 1991 |
Kemler I, Bucher E, Seipel K, Müller-Immerglück MM, Schaffner W. Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration. Nucleic Acids Research. 19: 237-42. PMID 2014164 DOI: 10.1093/Nar/19.2.237 |
0.46 |
|
| 1991 |
Zeng J, Heuchel R, Schaffner W, Kägi JHR. Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl Febs Letters. 279: 310-312. PMID 2001744 DOI: 10.1016/0014-5793(91)80175-3 |
0.522 |
|
| 1991 |
Yang J, Müller-Immerglück M, Seipel K, Janson L, Westin G, Schaffner W, Pettersson U. Both Oct-1 and Oct-2A contain domains which can activate the ubiquitously expressed U2 snRNA genes. The Embo Journal. 10: 2291-2296. DOI: 10.1002/J.1460-2075.1991.Tb07765.X |
0.455 |
|
| 1990 |
Heuchel R, Matthias P, Schaffner W. Two closely spaced promoters are equally activated by a remote enhancer: evidence against a scanning model for enhancer action. Nucleic Acids Research. 17: 8931-47. PMID 2555780 DOI: 10.1093/Nar/17.22.8931 |
0.355 |
|
| 1990 |
Kemler I, Schaffner W. Octamer transcription factors and the cell type-specificity of immunoglobulin gene expression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 1444-9. PMID 2407588 DOI: 10.1096/Fasebj.4.5.2407588 |
0.467 |
|
| 1990 |
Müller HP, Schaffner W. Transcriptional enhancers can act in trans. Trends in Genetics : Tig. 6: 300-4. PMID 2238088 DOI: 10.1016/0168-9525(90)90236-Y |
0.447 |
|
| 1990 |
Müller HP, Matthias P, Schaffner W. A transcriptional terminator between enhancer and promoter does not affect remote transcriptional control. Somatic Cell and Molecular Genetics. 16: 351-60. PMID 2218723 DOI: 10.1007/Bf01232463 |
0.461 |
|
| 1990 |
Schreiber E, Harshman K, Kemler I, Malipiero U, Schaffner W, Fontana A. Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins Nucleic Acids Research. 18: 5495-5503. PMID 2216722 DOI: 10.1093/Nar/18.18.5495 |
0.434 |
|
| 1990 |
Pettersson M, Schaffner W. Synergistic activation of transcription by multiple binding sites for NF-kappa B even in absence of co-operative factor binding to DNA. Journal of Molecular Biology. 214: 373-80. PMID 2199680 DOI: 10.1016/0022-2836(90)90187-Q |
0.452 |
|
| 1990 |
Thali M, Rusconi S, Schaffner W. Immediate early protein of pseudorabies virus is a general transactivator but stimulates only suboptimally utilized promoters. A clue to specificity Journal of Molecular Biology. 215: 301-311. PMID 2170665 DOI: 10.1016/S0022-2836(05)80348-1 |
0.461 |
|
| 1990 |
Elmaleh N, Matthias P, Schaffner W. A factor known to bind to endogenous Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor. European Journal of Biochemistry. 187: 507-13. PMID 2105887 DOI: 10.1111/J.1432-1033.1990.Tb15332.X |
0.43 |
|
| 1990 |
ARNOSTI D, KEMLER I, BUCHER E, MULLERIMMERGLUCK M, SEIPEL K, SCHAFFNER W. Octamer factors and cell type-specific gene expression Cell Biology International Reports. 14: 6. DOI: 10.1016/0309-1651(90)90132-I |
0.654 |
|
| 1990 |
Müller-Immerglück M, Schaffner W, Matthias P. Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. The Embo Journal. 9: 1625-1634. DOI: 10.1002/J.1460-2075.1990.Tb08282.X |
0.459 |
|
| 1990 |
Schatt M, Rusconi S, Schaffner W. A single DNA-binding transcription factor is sufficient for activation from a distant enhancer and/or from a promoter position. The Embo Journal. 9: 481-487. DOI: 10.1002/J.1460-2075.1990.Tb08134.X |
0.454 |
|
| 1989 |
Höller M, Westin G, Jiricny J, Schaffner W. Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated. Genes & Development. 2: 1127-35. PMID 3056778 DOI: 10.1101/Gad.2.9.1127 |
0.419 |
|
| 1989 |
Müller MM, Schreiber E, Schaffner W, Matthias P. Rapid test for in vivo stability and DNA binding of mutated octamer binding proteins with 'mini-extracts' prepared from transfected cells. Nucleic Acids Research. 17: 6420. PMID 2771660 DOI: 10.1093/Nar/17.15.6420 |
0.344 |
|
| 1989 |
Thomas RH, Schaffner W, Wilson AC, Pääbo S. DNA phylogeny of the extinct marsupial wolf. Nature. 340: 465-7. PMID 2755507 DOI: 10.1038/340465A0 |
0.308 |
|
| 1989 |
Schaffner W. How do different transcription factors binding the same DNA sequence sort out their jobs? Trends in Genetics : Tig. 5: 37-9. PMID 2646793 DOI: 10.1016/0168-9525(89)90017-6 |
0.443 |
|
| 1989 |
Schreiber E, Schaffner W. Long-range activation of transcription by SV40 enhancer is affected by "inhibitory" or "permissive" DNA sequences between enhancer and promoter. Somatic Cell and Molecular Genetics. 15: 591-603. PMID 2556801 DOI: 10.1007/Bf01534920 |
0.523 |
|
| 1989 |
Müller H, Sogo J, Schaffner W. An enhancer stimulates transcription in Trans when attached to the promoter via a protein bridge Cell. 58: 767-777. PMID 2548735 DOI: 10.1016/0092-8674(89)90110-4 |
0.484 |
|
| 1989 |
Iguchi-Ariga SM, Schaffner W. CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. Genes & Development. 3: 612-9. PMID 2545524 DOI: 10.1101/Gad.3.5.612 |
0.46 |
|
| 1989 |
Kemler I, Schreiber E, Müller MM, Matthias P, Schaffner W. Octamer transcription factors bind to two different sequence motifs of the immunoglobulin heavy chain promoter. The Embo Journal. 8: 2001-2008. DOI: 10.1002/J.1460-2075.1989.Tb03607.X |
0.458 |
|
| 1988 |
Schaffner W. A hit-and-run mechanism for transcriptional activation? Nature. 336: 427-428. PMID 3194030 DOI: 10.1038/336427A0 |
0.367 |
|
| 1988 |
Westin G, Schaffner W. Heavy metal ions in transcription factors from HeLa cells: Sp1, but not octamer transcription factor requires zinc for DNA binding and for activator function. Nucleic Acids Research. 16: 5771-81. PMID 3135532 DOI: 10.1093/Nar/16.13.5771 |
0.5 |
|
| 1988 |
Müller MM, Gerster T, Schaffner W. Enhancer sequences and the regulation of gene transcription. European Journal of Biochemistry / Febs. 176: 485-95. PMID 3049082 DOI: 10.1111/J.1432-1033.1988.Tb14306.X |
0.457 |
|
| 1988 |
Müller MM, Ruppert S, Schaffner W, Matthias P. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. Nature. 336: 544-51. PMID 2904653 DOI: 10.1038/336544A0 |
0.499 |
|
| 1988 |
Schaffner G, Schirm S, Müller-Baden B, Weber F, Schaffner W. Redundancy of information in enhancers as a principle of mammalian transcription control. Journal of Molecular Biology. 201: 81-90. PMID 2843647 DOI: 10.1016/0022-2836(88)90440-8 |
0.46 |
|
| 1988 |
Petterson M, Schaffner W. A purine-rich DNA sequence motif present in SV40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells. Genes & Development. 1: 962-72. PMID 2828177 DOI: 10.1101/Gad.1.9.962 |
0.439 |
|
| 1988 |
Schirm S, Jiricny J, Schaffner W. The SV40 enhancer can be dissected into multiple segments, each with a different cell type specificity. Genes & Development. 1: 65-74. PMID 2828161 DOI: 10.1101/Gad.1.1.65 |
0.42 |
|
| 1988 |
Schreiber E, Matthias P, Müller MM, Schaffner W. Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA). The Embo Journal. 7: 4221-4229. DOI: 10.1002/J.1460-2075.1988.Tb03319.X |
0.437 |
|
| 1988 |
Westin G, Schaffner W. A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene. The Embo Journal. 7: 3763-3770. DOI: 10.1002/J.1460-2075.1988.Tb03260.X |
0.506 |
|
| 1988 |
Severne Y, Wieland S, Schaffner W, Rusconi S. Metal binding ‘finger’ structures in the glucocorticoid receptor defined by site-directed mutagenesis. The Embo Journal. 7: 2503-2508. DOI: 10.1002/J.1460-2075.1988.Tb03097.X |
0.377 |
|
| 1987 |
Westin G, Gerster T, Müller MM, Schaffner G, Schaffner W. OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts. Nucleic Acids Research. 15: 6787-98. PMID 3658668 DOI: 10.1093/Nar/15.17.6787 |
0.519 |
|
| 1987 |
Kretsovali A, Müller MM, Weber F, Marcaud L, Farache G, Schreiber E, Schaffner W, Scherrer K. A transcriptional enhancer located between adult beta-globin and embryonic epsilon-globin genes in chicken and duck. Gene. 58: 167-75. PMID 3428615 DOI: 10.1016/0378-1119(87)90373-8 |
0.431 |
|
| 1987 |
Serfling E, Schaffner W. Inducible and constitutive sequence elements in the enhancer of the mouse metallothionein-I gene. Experientia. Supplementum. 52: 415-22. PMID 2822464 DOI: 10.1007/978-3-0348-6784-9_40 |
0.512 |
|
| 1987 |
Gerster T, Matthias P, Thali M, Jiricny J, Schaffner W. Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer. The Embo Journal. 6: 1323-1330. DOI: 10.1002/J.1460-2075.1987.Tb02371.X |
0.477 |
|
| 1986 |
Klein S, Gerster T, Picard D, Radbruch A, Schaffner W. Evidence for transient requirement of the IgH enhancer. Nucleic Acids Research. 13: 8901-12. PMID 3936022 DOI: 10.1093/Nar/13.24.8901 |
0.624 |
|
| 1986 |
Gerster T, Picard D, Schaffner W. During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation. Cell. 45: 45-52. PMID 3082521 DOI: 10.1016/0092-8674(86)90536-2 |
0.393 |
|
| 1986 |
Dorsch-Häsler K, Keil GM, Weber F, Jasin M, Schaffner W, Koszinowski UH. A long and complex enhancer activates transcription of the gene coding for the highly abundant immediate early mRNA in murine cytomegalovirus. Proceedings of the National Academy of Sciences of the United States of America. 82: 8325-9. PMID 3001696 DOI: 10.1073/Pnas.82.24.8325 |
0.64 |
|
| 1986 |
Jasin M, de Villiers J, Weber F, Schaffner W. High frequency of homologous recombination in mammalian cells between endogenous and introduced SV40 genomes. Cell. 43: 695-703. PMID 3000612 DOI: 10.1016/0092-8674(85)90242-9 |
0.584 |
|
| 1986 |
Pääbo S, Weber F, Nilsson T, Schaffner W, Peterson P. Structural and functional dissection of an MHC class I antigen-binding adenovirus glycoprotein. The Embo Journal. 5: 1921-1927. DOI: 10.1002/J.1460-2075.1986.Tb04445.X |
0.313 |
|
| 1985 |
Tognoni A, Cattaneo R, Serfling E, Schaffner W. A novel expression selection approach allows precise mapping of the hepatitis B virus enhancer. Nucleic Acids Research. 13: 7457-72. PMID 2997748 DOI: 10.1093/Nar/13.20.7457 |
0.384 |
|
| 1985 |
Weber F, Schaffner W. Simian virus 40 enhancer increases RNA polymerase density within the linked gene. Nature. 315: 75-77. PMID 2986014 DOI: 10.1038/315075A0 |
0.464 |
|
| 1985 |
Boshart M, Weber F, Jahn G, Dorsch-Häsler K, Fleckenstein B, Schaffner W. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell. 41: 521-30. PMID 2985280 DOI: 10.1016/S0092-8674(85)80025-8 |
0.494 |
|
| 1985 |
Serfling E, Jasin M, Schaffner W. Enhancers and eukaryotic gene transcription Trends in Genetics. 1: 224-230. DOI: 10.1016/0168-9525(85)90088-5 |
0.659 |
|
| 1985 |
Lübbe A, Schaffner W. Tissue-specific gene expression Trends in Neurosciences. 8: 100-104. DOI: 10.1016/0166-2236(85)90046-3 |
0.471 |
|
| 1985 |
Serfling E, Lübbe A, Dorsch-Häsler K, Schaffner W. Metal-dependent SV40 viruses containing inducible enhancers from the upstream region of metallothionein genes. The Embo Journal. 4: 3851-3859. DOI: 10.1002/J.1460-2075.1985.Tb04157.X |
0.466 |
|
| 1985 |
Picard D, Schaffner W. Cell-type preference of immunoglobulin kappa and lambda gene promoters. The Embo Journal. 4: 2831-2838. DOI: 10.1002/J.1460-2075.1985.Tb04011.X |
0.61 |
|
| 1985 |
Schirm S, Weber F, Schaffner W, Fleckenstein B. A transcription enhancer in the Herpesvirus saimiri genome. The Embo Journal. 4: 2669-2674. DOI: 10.1002/J.1460-2075.1985.Tb03986.X |
0.42 |
|
| 1985 |
Weber F, Schaffner W. Enhancer activity correlates with the oncogenic potential of avian retroviruses. The Embo Journal. 4: 949-956. DOI: 10.1002/J.1460-2075.1985.Tb03723.X |
0.35 |
|
| 1984 |
Picard D, Schaffner W. A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene. Nature. 307: 80-2. PMID 6419128 DOI: 10.1038/307080A0 |
0.449 |
|
| 1984 |
Weber F, Villiers Jd, Schaffner W. An SV40 "enhancer trap" incorporates exogenous enhancers or generates enhancers from its own sequences. Cell. 36: 983-992. PMID 6323032 DOI: 10.1016/0092-8674(84)90048-5 |
0.405 |
|
| 1984 |
de Villiers J, Schaffner W, Tyndall C, Lupton S, Kamen R. Polyoma virus DNA replication requires an enhancer. Nature. 312: 242-6. PMID 6095089 DOI: 10.1038/312242A0 |
0.437 |
|
| 1983 |
Banerji J, Olson L, Schaffner W. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell. 33: 729-40. PMID 6409418 DOI: 10.1016/0092-8674(83)90015-6 |
0.473 |
|
| 1983 |
de Villiers J, Olson L, Banerji J, Schaffner W. Analysis of the transcriptional enhancer effect. Cold Spring Harbor Symposia On Quantitative Biology. 911-9. PMID 6305591 DOI: 10.1101/Sqb.1983.047.01.105 |
0.376 |
|
| 1983 |
Pääbo S, Weber F, Kämpe O, Schaffner W, Peterson PA. Association between transplantation antigens and a viral membrane protein synthesized from a mammalian expression vector. Cell. 33: 445-53. PMID 6305511 DOI: 10.1016/0092-8674(83)90426-9 |
0.338 |
|
| 1983 |
Picard D, Schaffner W. Correct transcription of a cloned mouse immunoglobulin gene in vivo. Proceedings of the National Academy of Sciences of the United States of America. 80: 417-21. PMID 6300842 DOI: 10.1073/Pnas.80.2.417 |
0.643 |
|
| 1983 |
de Villiers J, Olson L, Tyndall C, Schaffner W. Transcriptional 'enhancers' from SV40 and polyoma virus show a cell type preference. Nucleic Acids Research. 10: 7965-76. PMID 6298703 DOI: 10.1093/Nar/10.24.7965 |
0.421 |
|
| 1983 |
Banerji J, Schaffner W. Transient Expression of Cloned Genes in Mammalian Cells Genetic Engineering. 5: 19-32. DOI: 10.1007/978-1-4684-4556-5_2 |
0.433 |
|
| 1982 |
Rusconi S, Schaffner W. Transformation of frog embryos with a rabbit beta-globin gene. Proceedings of the National Academy of Sciences of the United States of America. 78: 5051-5. PMID 6946453 DOI: 10.1073/Pnas.78.8.5051 |
0.409 |
|
| 1982 |
Banerji J, Rusconi S, Schaffner W. Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences. Cell. 27: 299-308. PMID 6277502 DOI: 10.1016/0092-8674(81)90413-X |
0.477 |
|
| 1982 |
de Villiers J, Schaffner W. A small segment of polyoma virus DNA enhances the expression of a cloned beta-globin gene over a distance of 1400 base pairs. Nucleic Acids Research. 9: 6251-64. PMID 6275354 DOI: 10.1093/Nar/9.23.6251 |
0.462 |
|
| 1980 |
Schaffner W. Direct transfer of cloned genes from bacteria to mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 77: 2163-7. PMID 6246525 DOI: 10.1073/Pnas.77.4.2163 |
0.368 |
|
| 1978 |
Schaffner W, Kunz G, Daetwyler H, Telford J, Smith HO, Birnstiel ML. Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing Cell. 14: 655-671. PMID 688387 DOI: 10.1016/0092-8674(78)90249-0 |
0.645 |
|
| 1978 |
Müller HK, Wittek R, Schaffner W, Schümperli D, Menna A, Wyler R. Comparison of five poxvirus genomes by analysis with restriction endonucleases HindIII, BamI and EcoRI. The Journal of General Virology. 38: 135-47. PMID 202667 DOI: 10.1099/0022-1317-38-1-135 |
0.319 |
|
| 1978 |
Birnstiel ML, Kressmann A, Schaffner W, Portmann R, Busslinger M. Aspects of the regulation of histone genes Philosophical Transactions of the Royal Society of London Series B Biological Sciences. 283: 319-324. PMID 26076 DOI: 10.1098/Rstb.1978.0031 |
0.731 |
|
| 1977 |
Portmann R, Schaffner W, Birnstiel M. Partial denaturation mapping of cloned histone DNA from the sea urchin Psammechinus miliaris. Nature. 264: 31-4. PMID 1069909 DOI: 10.1038/264031A0 |
0.62 |
|
| 1977 |
Birnstiel ML, Schaffner W, Smith HO. DNA sequences coding for the H2B histone of Psammechinus miliaris Nature. 266: 603-607. PMID 870829 DOI: 10.1038/266603A0 |
0.626 |
|
| 1977 |
Telford J, Boseley P, Schaffner W, Birnstiel M. Novel screening procedure for recombinant plasmids. Science (New York, N.Y.). 195: 391-3. PMID 318763 DOI: 10.1126/Science.318763 |
0.585 |
|
| 1976 |
Clarkson SG, Smith HO, Schaffner W, Gross KW, Birnstiel ML. Integration of eukaryotic genes for 5S RNA and histone proteins into a phage lambda receptor Nucleic Acids Research. 3: 2617-2632. PMID 1069257 DOI: 10.1093/Nar/3.10.2617 |
0.76 |
|
| 1976 |
Gross K, Schaffner W, Telford J, Birnstiel M. Molecular analysis of the histone gene cluster of Psammechinus miliaris: III. Polarity and asymmetry of the histone-coding sequences. Cell. 8: 479-84. PMID 954101 DOI: 10.1016/0092-8674(76)90215-4 |
0.609 |
|
| 1976 |
Schaffner W, Gross K, Telford J, Birnstiel M. Molecular analysis of the histone gene cluster of psammechinus miliaris: II. The arrangement of the five histone-coding and spacer sequences. Cell. 8: 471-8. PMID 954100 DOI: 10.1016/0092-8674(76)90214-2 |
0.605 |
|
| 1976 |
Gross K, Probst E, Schaffner W, Birnstiel M. Molecular analysis of the histone gene cluster of Psammechinus miliaris: I. Fractionation and identification of five individual histone mRNAs. Cell. 8: 455-69. PMID 954099 DOI: 10.1016/0092-8674(76)90213-0 |
0.565 |
|
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