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Thomas A. Dix - Publications

Affiliations: 
1994- Pharmaceutical Sciences Medical University of South Carolina, Charleston, SC, United States 
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Beck TC, Hapstack MA, Ghatnekar GS, Dix TA. Diuretic Activity of a Novel Peripherally-Restricted Orally-Active Kappa Opioid Receptor Agonist. Medical Sciences (Basel, Switzerland). 7. PMID 31480425 DOI: 10.3390/Medsci7090093  0.318
2019 Beck TC, Reichel CM, Helke KL, Bhadsavle SS, Dix TA. Non-addictive orally-active kappa opioid agonists for the treatment of peripheral pain in rats. European Journal of Pharmacology. PMID 31103632 DOI: 10.1016/J.Ejphar.2019.05.025  0.303
2017 Beck T, Carmela R, Dix T. Peptide-Derived Kappa-Opioid Agonist as a Non-Addictive Analgesic for Peripheral Pain Archives of Physical Medicine and Rehabilitation. 98: e90-e91. DOI: 10.1016/J.Apmr.2017.08.290  0.333
2016 Beck T, Bhadsavle S, Kopfman M, Ghee S, Reichel C, Dix T. (313) Development of a peptide-derived orally-active kappa-opioid receptor agonists for peripheral pain in rats The Journal of Pain. 17: S54. DOI: 10.1016/J.Jpain.2016.01.220  0.369
2013 Hughes FM, Shaner BE, Brower JO, Woods RJ, Dix TA. Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain. The Open Medicinal Chemistry Journal. 7: 16-22. PMID 24222801 DOI: 10.2174/1874104501307010016  0.389
2010 Hughes FM, Shaner BE, May LA, Zotian L, Brower JO, Woods RJ, Cash M, Morrow D, Massa F, Mazella J, Dix TA. Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic. Journal of Medicinal Chemistry. 53: 4623-32. PMID 20481538 DOI: 10.1021/Jm100092S  0.39
2010 Lundquist IV JT, Orwig KS, Dix TA. ChemInform Abstract: Synthesis of Ethylene-Bridged (Nδ to Nω) Analogues of Arginine. Cheminform. 31: no-no. DOI: 10.1002/chin.200011200  0.758
2010 LUNDQUIST JTI, BUELLESBACH EE, DIX TA. ChemInform Abstract: Synthesis of Protected ω-Mercapto Amino Acids: Precursors for Incorporation of Elongated Cysteines into Peptides. Cheminform. 29: no-no. DOI: 10.1002/CHIN.199852245  0.364
2009 Orwig KS, Lassetter MR, Hadden MK, Dix TA. Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy. Journal of Medicinal Chemistry. 52: 1803-13. PMID 19290594 DOI: 10.1021/Jm801072V  0.767
2005 Hadden MK, Orwig KS, Kokko KP, Mazella J, Dix TA. Design, synthesis, and evaluation of the antipsychotic potential of orally bioavailable neurotensin (8-13) analogues containing non-natural arginine and lysine residues. Neuropharmacology. 49: 1149-59. PMID 16095636 DOI: 10.1016/J.Neuropharm.2005.06.010  0.731
2005 Hadden MK, Walle T, Dix TA. Cellular uptake of a radiolabelled analogue of neurotensin in the Caco-2 cell model. The Journal of Pharmacy and Pharmacology. 57: 327-33. PMID 15807988 DOI: 10.1211/0022357055560  0.662
2005 Kokko KP, Hadden MK, Price KL, Orwig KS, See RE, Dix TA. In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrier. Neuropharmacology. 48: 417-25. PMID 15721174 DOI: 10.1016/J.Neuropharm.2004.10.008  0.735
2005 Hadden MK, Kokko KP, Dix TA. Asymmetric Synthesis of ω‐Bromo‐2(S)‐Methyl Acids as Precursors for Novel Arginine, Lysine, and Mercapto Residues Synthetic Communications. 35: 1675-1680. DOI: 10.1081/Scc-200061668  0.801
2005 Orwig KS, Dix TA. Synthesis of Cα methylated carboxylic acids: isosteres of arginine and lysine for use as N-terminal capping residues in polypeptides Tetrahedron Letters. 46: 7007-7009. DOI: 10.1016/J.Tetlet.2005.08.056  0.779
2005 Hadden MK, Kokko KP, Dix TA. Asymmetric Synthesis of ω-Bromo-2(S)-methyl Acids as Precursors for Novel Arginine, Lysine, and Mercapto Residues. Cheminform. 36. DOI: 10.1002/CHIN.200547188  0.776
2004 Kokko KP, Hooper HB, Dix TA. Synthesis of cyclic and acyclic Nα-methyl-Nω-alkyl-L-arginine analogues Tetrahedron Letters. 45: 2151-2153. DOI: 10.1016/J.Tetlet.2004.01.047  0.778
2003 Kokko KP, Hadden MK, Orwig KS, Mazella J, Dix TA. In vitro analysis of stable, receptor-selective neurotensin[8-13] analogues. Journal of Medicinal Chemistry. 46: 4141-8. PMID 12954066 DOI: 10.1021/Jm0300633  0.749
2002 Kokko KP, Dix TA. Monitoring neurotensin[8-13] degradation in human and rat serum utilizing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Analytical Biochemistry. 308: 34-41. PMID 12234461 DOI: 10.1016/S0003-2697(02)00235-X  0.717
2002 Kennedy KJ, Orwig KS, Dix TA, Christopher J, Jaffa AA. Synthesis and analysis of potent, more lipophilic derivatives of the bradykinin B2 receptor antagonist peptide Hoe 140. The Journal of Peptide Research : Official Journal of the American Peptide Society. 59: 139-48. PMID 11972749 DOI: 10.1034/J.1399-3011.2002.1O987.X  0.805
2002 Lundquist JT, Büllesbach EE, Golden PL, Dix TA. Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs. The Journal of Peptide Research : Official Journal of the American Peptide Society. 59: 55-61. PMID 11906607 DOI: 10.1046/J.1397-002X.2001.10946.X  0.479
2001 Kokko KP, Arrigoni CE, Dix TA. Selectivity enhancement induced by substitution of non-natural analogues of arginine and lysine in arginine-based thrombin inhibitors. Bioorganic & Medicinal Chemistry Letters. 11: 1947-50. PMID 11459667 DOI: 10.1016/S0960-894X(01)00328-6  0.749
2000 Kennedy KJ, Lundquist IV JT, Simandan TL, Kokko KP, Beeson CC, Dix TA. Design rationale, synthesis, and characterization of non-natural analogs of the cationic amino acids arginine and lysine Journal of Peptide Research. 55: 348-358. PMID 10798380 DOI: 10.1034/J.1399-3011.2000.00688.X  0.807
2000 Lundquist JT, Büllesbach EE, Dix TA. Synthesis of neurotensin(9-13) analogues exhibiting enhanced human neurotensin receptor binding affinities. Bioorganic & Medicinal Chemistry Letters. 10: 453-5. PMID 10743946 DOI: 10.1016/S0960-894X(00)00018-4  0.377
1999 Lundquist JT, Dix TA. Synthesis and human neurotensin receptor binding activities of neurotensin(8-13) analogues containing position 8 alpha-azido-N-alkylated derivatives of ornithine, lysine, and homolysine. Journal of Medicinal Chemistry. 42: 4914-8. PMID 10579853 DOI: 10.1021/JM9903444  0.411
1999 Lundquist JT, Dix TA. Preparation and receptor binding affinities of cyclic C-terminal neurotensin (8-13) and (9-13) analogues. Bioorganic & Medicinal Chemistry Letters. 9: 2579-82. PMID 10498212 DOI: 10.1016/S0960-894X(99)00420-5  0.384
1999 Lundquist JT, Orwig aKS, Dix TA. Synthesis of Ethylene-Bridged (Nδ to Nω) Analogues of Arginine Journal of Organic Chemistry. 64: 9265-9267. DOI: 10.1021/Jo990551B  0.364
1998 Kennedy KJ, Simandan TL, Dix TA. A Facile Route to Cyclic and Acyclic Alkyl-Arginines Synthetic Communications. 28: 741-746. DOI: 10.1080/00397919808005947  0.36
1998 Lundquist JT, Büllesbach EE, Dix TA. Synthesis of protected ω-mercapto amino acids: precursors for incorporation of elongated cysteines into peptides Tetrahedron: Asymmetry. 9: 2739-2743. DOI: 10.1016/S0957-4166(98)00261-4  0.46
1998 Lundquist JT, Dix TA. Asymmetric synthesis of ω-bromo-2(S)-azido acids as precursors for the synthesis of novel amino acids Tetrahedron Letters. 39: 775-778. DOI: 10.1016/S0040-4039(97)10608-6  0.406
1997 Kennedy KJ, Lundquist IV JT, Simandan TL, Beeson CC, Dix TA. Asymmetric synthesis of non-natural homologues of lysine Bioorganic and Medicinal Chemistry Letters. 7: 1937-1940. DOI: 10.1016/S0960-894X(97)00335-1  0.678
1993 Beeson C, Dix TA. Thermodynamic description of a contact and solvent-separated ion pair as a function of solvation: A model for salt bridges and proton-transfer reactions in biology Journal of the American Chemical Society. 115: 10267-10274. DOI: 10.1021/Ja00075A049  0.578
1993 Beeson C, Pham N, Shipps G, Dix TA. A comprehensive description of the free energy of an intramolecular hydrogen bond as a function of solvation: NMR study Journal of the American Chemical Society. 115: 6803-6812. DOI: 10.1021/Ja00068A043  0.535
1992 Beeson C, Dix TA. Design and synthesis of intramolecular ion-pairing cis-bicyclo[4.4.0]decane (cis-decalin) amino acids: Conformation-based probes of electrostatic interactions in water Journal of Organic Chemistry. 57: 4386-4394. DOI: 10.1021/Jo00042A015  0.598
1992 Beeson C, Pham N, Dix TA. Stereoelectronic influence on the NaBH4 reduction stereoselectivity of alicyclic β-ketoesters Tetrahedron Letters. 33: 2925-2928. DOI: 10.1016/S0040-4039(00)79562-1  0.49
1991 Beeson C, Dix TA. Control of peptide conformational preferences by intramolecular ion-pairing: A NMR and molecular mechanics analysis of glycyl-containing dipeptides in aqueous solutions Journal of the Chemical Society, Perkin Transactions 2. 1913-1918. DOI: 10.1039/P29910001913  0.588
1986 Dix TA, Buck JR, Marnett LJ. Hydroperoxide-dependent epoxidation of 3,4-dihydroxy-3,4-dihydrobenzo[a]anthracene by ram seminal vesicle microsomes and by hematin. Biochemical and Biophysical Research Communications. 140: 181-7. PMID 3096315 DOI: 10.1016/0006-291X(86)91074-0  0.378
1984 Dix TA, Marnett LJ. Detection of the metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation. Methods in Enzymology. 105: 347-52. PMID 6539415 DOI: 10.1016/S0076-6879(84)05046-1  0.436
1983 Dix TA, Marnett LJ. Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation. Science (New York, N.Y.). 221: 77-9. PMID 6304879 DOI: 10.1126/Science.6304879  0.443
1983 Dix TA, Marnett LJ. Hematin-catalyzed rearrangement of hydroperoxylinoleic acid to epoxy alcohols via an oxygen rebound Journal of the American Chemical Society. 105: 7001-7002. DOI: 10.1021/Ja00361A063  0.423
1982 DIX TA, MARNETT LJ. ChemInform Abstract: FREE RADICAL EPOXIDATION OF 7,8-DIHYDROXY-7,8-DIHYDROBENZO(A)PYRENE BY HEMATIN AND POLYUNSATURATED FATTY ACID HYDROPEROXIDES Chemischer Informationsdienst. 13. DOI: 10.1002/CHIN.198207129  0.395
1981 Dix TA, Marnett LJ. Free radical epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by hematin and polyunsaturated fatty acid hydroperoxides Journal of the American Chemical Society. 103: 6744-6746. DOI: 10.1021/Ja00412A037  0.46
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