Frédéric Saudou, PhD - Related publications

Affiliations: 
1999-2013 Inserm U1005 Institut Curie, Bures-sur-Yvette, Île-de-France, France 
 2013- Grenoble Institute of Neurosciences Université Grenoble Alpes, INSERM 
Area:
Huntington's disease, intracellular dynamics, axonal transport
Website:
https://neurosciences.ujf-grenoble.fr/search/team-saudou-intracellular-dynamics-neurodegeneration?language=en
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Sharma A, Behl T, Sharma L, Aelya L, Bungau S. Mitochondrial Dysfunction in Huntington's disease: Pathogenesis and Therapeutic Opportunities. Current Drug Targets. PMID 33655829 DOI: 10.2174/1389450122666210224105945   
2021 Luo M, Shi X, Guo Q, Li S, Zhang Q, Sun X, Piao F. 2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways. Bioscience Reports. PMID 33792642 DOI: 10.1042/BSR20204264   
2021 Khaled HG, Feng H, Hu X, Sun X, Zheng W, Li PP, Rudnicki DD, Ye W, Chen YC, Southall N, Marugan J, Ross CA, Ferrer M, Henderson MJ, Margolis RL. A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity. Scientific Reports. 11: 6157. PMID 33731741 DOI: 10.1038/s41598-021-85279-2   
2021 Sun CY, Li JR, Wang YY, Lin SY, Ou YC, Lin CJ, Wang JD, Liao SL, Chen CJ. Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy. Aging. 13. PMID 33621199 DOI: 10.18632/aging.202523   
2021 Moon JH, Hong JM, Park SY. The antidiabetic drug troglitazone protects against PrP (106‑126)‑induced neurotoxicity via the PPARγ‑autophagy pathway in neuronal cells. Molecular Medicine Reports. 23. PMID 33846779 DOI: 10.3892/mmr.2021.12069   
2021 Yang G, Wan P, Xiang Q, Huang S, Huang S, Wang J, Wu K, Wu J. E3 Ubiquitin Ligase ASB17 Promotes Apoptosis by Ubiquitylating and Degrading BCLW and MCL1. Biology. 10. PMID 33803505 DOI: 10.3390/biology10030234   
2021 Liu S, Feng Y, Huang Y, Jiang X, Tang C, Tang F, Zeng C, Liu L. A GM1 gangliosidosis mutant mouse model exhibits activated microglia and disturbed autophagy. Experimental Biology and Medicine (Maywood, N.J.). 1535370221993052. PMID 33583210 DOI: 10.1177/1535370221993052   
2021 Rippin I, Bonder K, Joseph SB, Sarsor A, Vaks L, Eldar-Finkelman H. Inhibition of GSK-3 ameliorates the pathogenesis of Huntington's disease. Neurobiology of Disease. 105336. PMID 33753290 DOI: 10.1016/j.nbd.2021.105336   
2021 Kwon OY, Lee SH. Suppresses Trimethyltin-Induced Neurodegeneration and Glutamate-Mediated Excitotoxicity by Regulating MAPKs/Nrf2/HO-1 Antioxidant Pathways. Antioxidants (Basel, Switzerland). 10. PMID 33809381 DOI: 10.3390/antiox10030440   
2021 Sun X, Kato H, Sato H, Torio M, Han X, Zhang Y, Hirofuji Y, Kato TA, Sakai Y, Ohga S, Fukumoto S, Masuda K. Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia. Biochemistry and Biophysics Reports. 26: 100968. PMID 33748438 DOI: 10.1016/j.bbrep.2021.100968   
2021 Simmons DA, Mills BD, Butler Iii RR, Kuan J, McHugh TLM, Akers C, Zhou J, Syriani W, Grouban M, Zeineh M, Longo FM. Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75 Ligand LM11A-31. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33786806 DOI: 10.1007/s13311-021-01023-8   
2021 Ribon M, Leone C, Chiot A, Berriat F, Rampanana M, Cottin J, Bohl D, Millecamps S, Lobsiger CS, Heneka MT, Boillée S. Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1 ALS mice. Neurobiology of Aging. 101: 181-186. PMID 33626479 DOI: 10.1016/j.neurobiolaging.2021.01.015   
2021 Yang MH, Chen YA, Tu SC, Chi PL, Chuang KP, Chang CC, Lee CH, Chen YL, Lee CH, Yuan CH, Tyan YC. Utilizing an Animal Model to Identify Brain Neurodegeneration-Related Biomarkers in Aging. International Journal of Molecular Sciences. 22. PMID 33807010 DOI: 10.3390/ijms22063278   
2021 Xiong S, Ma M, Xu Y, Wei F, Gu Q, He X, Xu X. Protective effects of peptide FK18 against neuro-excitotoxicity in SH-SY5Y cells. Experimental and Therapeutic Medicine. 21: 451. PMID 33747186 DOI: 10.3892/etm.2021.9880   
2021 Sun J, Qin X, Zhang X, Wang Q, Zhang W, Wang M. FBXW11 deletion alleviates Alzheimer's disease by reducing neuroinflammation and amyloid-β plaque formation via repression of ASK1 signaling. Biochemical and Biophysical Research Communications. 548: 104-111. PMID 33640602 DOI: 10.1016/j.bbrc.2020.12.081   
2021 Cleverley K, Lee WC, Mumford P, Collins T, Rickman M, Cunningham TJ, Cleak J, Mianne J, Szoke-Kovacs Z, Stewart M, Teboul L, Maduro C, Wells S, Wiseman FK, Fisher EMC. A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 33713180 DOI: 10.1007/s00335-021-09864-6   
2021 Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M. Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS. Molecular Therapy. Nucleic Acids. 24: 1-10. PMID 33738134 DOI: 10.1016/j.omtn.2021.02.007   
2021 Zhang XH, Tang LY, Wang XY, Shen CL, Xiong WF, Shen Y, Wan YH, Wu YB, Wang YC, Zhang HX, Lu SY, Fei J, Wang ZG. ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus-pituitary-thyroid axis in male mice. Cell Death & Disease. 12: 362. PMID 33824276 DOI: 10.1038/s41419-021-03634-7   
2021 Tang J, Kang Y, Zhou Y, Li X, Lan J, Wu L, Feng X, Peng Y. ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis. Neurobiology of Disease. 105315. PMID 33636390 DOI: 10.1016/j.nbd.2021.105315   
2021 Maekura K, Tsukamoto S, Hamada-Kanazawa M, Takano M. Rimklb mutation causes male infertility in mice. Scientific Reports. 11: 4604. PMID 33633267 DOI: 10.1038/s41598-021-84105-z   
2021 Chung Y, Kim Y, Yun N, Oh YJ. Dysregulated autophagy is linked to BAX oligomerization and subsequent cytochrome c release in 6-hydroxydopmaine-treated neuronal cells. Biochemical and Biophysical Research Communications. 548: 20-26. PMID 33631669 DOI: 10.1016/j.bbrc.2021.02.045   
2021 Stum MG, Tadenev ALD, Seburn KL, Miers KE, Poon PP, McMaster CR, Robinson C, Kane C, Silva KA, Cliften PF, Sundberg JP, Reinholdt LG, John SWM, Burgess RW. Genetic analysis of Pycr1 and Pycr2 in mice. Genetics. PMID 33734376 DOI: 10.1093/genetics/iyab048   
2021 Huang CF, Liu SH, Su CC, Fang KM, Yen CC, Yang CY, Tang FC, Liu JM, Wu CC, Lee KI, Chen YW. Roles of ERK/Akt signals in mitochondria-dependent and endoplasmic reticulum stress-triggered neuronal cell apoptosis induced by 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a major active metabolite of bisphenol A. Toxicology. 152764. PMID 33771661 DOI: 10.1016/j.tox.2021.152764   
2021 Kumar AP, Prabitha P, Kumar BRP, Jeyarani V, Dhanabal SP, Justin A. Glitazones, PPAR-γ and Neuroprotection. Mini Reviews in Medicinal Chemistry. PMID 33663364 DOI: 10.2174/1389557521666210304112403   
2021 Betônico Berg B, Soares JS, Paiva IR, Rezende BM, Rachid MA, Cau SBA, Romero TRL, Pinho V, Teixeira MM, Castor MGM. . The Journal of Pharmacology and Experimental Therapeutics. PMID 33658314 DOI: 10.1124/jpet.120.000479   
2021 Bose K, Wagh A, Mishra V, Dutta S, Parui AL, Puja R, Mudrale SP, Kulkarni SS, Gai PB, Sarin R. Loss of GSK-3β mediated phosphorylation in HtrA2 contributes to uncontrolled cell death with Parkinsonian phenotype. International Journal of Biological Macromolecules. PMID 33716130 DOI: 10.1016/j.ijbiomac.2021.03.040   
2021 Doroshenko ER, Drohomyrecky PC, Gower A, Whetstone H, Cahill LS, Ganguly M, Spring S, Yi TJ, Sled JG, Dunn SE. Peroxisome Proliferator-Activated Receptor-δ Deficiency in Microglia Results in Exacerbated Axonal Injury and Tissue Loss in Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology. 12: 570425. PMID 33732230 DOI: 10.3389/fimmu.2021.570425   
2021 Wang L, Deng B, Yan P, Wu H, Li C, Zhu H, Du J, Hou L. Neuroprotective effect of ketamine against TNF-α-induced necroptosis in hippocampal neurons. Journal of Cellular and Molecular Medicine. PMID 33660415 DOI: 10.1111/jcmm.16426   
2021 Hannan FM, Stevenson M, Bayliss AL, Stokes VJ, Stewart M, Kooblall KG, Gorvin CM, Codner G, Teboul L, Wells S, Thakker RV. Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2. Human Molecular Genetics. PMID 33729479 DOI: 10.1093/hmg/ddab076   
2021 Naia L, Ly P, Mota SI, Lopes C, Maranga C, Coelho P, Gershoni-Emek N, Ankarcrona M, Geva M, Hayden MR, Rego AC. The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33797036 DOI: 10.1007/s13311-021-01022-9   
2021 Moore K, Fulmer D, Guo L, Koren N, Glover J, Moore R, Gensemer C, Beck T, Morningstar J, Stairley R, Norris RA. PDGFRα: Expression and Function during Mitral Valve Morphogenesis. Journal of Cardiovascular Development and Disease. 8. PMID 33805717 DOI: 10.3390/jcdd8030028   
2021 Omarjee O, Mathieu AL, Quiniou G, Moreews M, Ainouze M, Frachette C, Melki I, Dumaine C, Gerfaud-Valentin M, Duquesne A, Kallinich T, Tahir Turanli E, Malcus C, Viel S, Pescarmona R, et al. LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages. The Journal of Experimental Medicine. 218. PMID 33606008 DOI: 10.1084/jem.20201006   
2021 Wu H, Xu X, Zheng A, Wang W, Mei L, Chen Y, Sun S, Jiang L, Wu Y, Zhou Y, Zheng M, Chen Q. TIPE1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of ASK1. Hepatology (Baltimore, Md.). PMID 33713358 DOI: 10.1002/hep.31801   
2021 Ruel J, Guitton MJ, Gratias P, Lenoir M, Shen S, Puel JL, Brabet P, Wang J. Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Plays a Protective Effect Against Noise-Induced Hearing Loss. Frontiers in Cellular Neuroscience. 15: 658990. PMID 33828461 DOI: 10.3389/fncel.2021.658990   
2021 Donaldson J, Powell S, Rickards N, Holmans P, Jones L. What is the Pathogenic CAG Expansion Length in Huntington's Disease? Journal of Huntington's Disease. 10: 175-202. PMID 33579866 DOI: 10.3233/JHD-200445   
2021 Liu L, Liang L, Yang C, Zhou Y, Chen Y. Extracellular vesicles of Fusobacterium nucleatum compromise intestinal barrier through targeting RIPK1-mediated cell death pathway. Gut Microbes. 13: 1-20. PMID 33769187 DOI: 10.1080/19490976.2021.1902718   
2021 Paul S, Pickrell AM. Hidden phenotypes of PINK1/Parkin knockout mice. Biochimica Et Biophysica Acta. General Subjects. 1865: 129871. PMID 33571581 DOI: 10.1016/j.bbagen.2021.129871   
2021 Tandon S, Sarkar S. The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila. Life Sciences. 119358. PMID 33744321 DOI: 10.1016/j.lfs.2021.119358   
2021 Jung IH, Elenbaas JS, Alisio A, Santana K, Young EP, Kang CJ, Kachroo P, Lavine KJ, Razani B, Mecham RP, Stitziel NO. SVEP1 is a human coronary artery disease locus that promotes atherosclerosis. Science Translational Medicine. 13. PMID 33762433 DOI: 10.1126/scitranslmed.abe0357   
2021 Rianto F, Hoang T, Revoori R, Sparks MA. Angiotensin Receptors in the Kidney and Vasculature in Hypertension and Kidney Disease. Molecular and Cellular Endocrinology. 111259. PMID 33781840 DOI: 10.1016/j.mce.2021.111259   
2021 Müller K, Honcharova-Biletska H, Koppe C, Egger M, Chan LK, Schneider AT, Küsgens L, Böhm F, Boege Y, Healy ME, Schmitt J, Comtesse S, Castoldi M, Preisinger C, Szydlowska M, et al. JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33798093 DOI: 10.1073/pnas.2007194118   
2021 Sannomiya Y, Kaseda S, Kamura M, Yamamoto H, Yamada H, Inamoto M, Kuwazuru J, Niino S, Shuto T, Suico MA, Kai H. The role of discoidin domain receptor 2 in the renal dysfunction of alport syndrome mouse model. Renal Failure. 43: 510-519. PMID 33706638 DOI: 10.1080/0886022X.2021.1896548   
2021 van Leent MMT, Beldman TJ, Toner YC, Lameijer MA, Rother N, Bekkering S, Teunissen AJP, Zhou X, van der Meel R, Malkus J, Nauta SA, Klein ED, Fay F, Sanchez-Gaytan BL, Pérez-Medina C, et al. Prosaposin mediates inflammation in atherosclerosis. Science Translational Medicine. 13. PMID 33692130 DOI: 10.1126/scitranslmed.abe1433   
2021 Blasiak J, Koskela A, Pawlowska E, Liukkonen M, Ruuth J, Toropainen E, Hyttinen JMT, Viiri J, Eriksson JE, Xu H, Chen M, Felszeghy S, Kaarniranta K. Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of Double Knock-Out Mice. International Journal of Molecular Sciences. 22. PMID 33567500 DOI: 10.3390/ijms22041684   
2021 Kim DH, Park JS, Choi HI, Kim CS, Bae EH, Ma SK, Kim SW. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD. Cell Death & Disease. 12: 320. PMID 33767132 DOI: 10.1038/s41419-021-03620-z   
2021 Hecht JT, Coustry F, Veerisetty AC, Hossain MG, Posey KL. Resveratrol Reduces COMPopathy in Mice Through Activation of Autophagy. Jbmr Plus. 5: e10456. PMID 33778324 DOI: 10.1002/jbm4.10456   
2021 Jiang H, Hooper C, Kelly M, Steeples V, Simon JN, Beglov J, Azad AJ, Leinhos L, Bennett P, Ehler E, Kalisch-Smith JI, Sparrow DB, Fischer R, Heilig R, Isackson H, et al. Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant. Basic Research in Cardiology. 116: 14. PMID 33637999 DOI: 10.1007/s00395-021-00853-z   
2021 Inoue M, Yamashita K, Tsuji Y, Miki M, Amano S, Okumura T, Kuge K, Tone T, Enomoto S, Yoshimine C, Morita Y, Ando D, Kamada H, Mikami N, Tsutsumi Y, et al. Characterization of a TNFR2-Selective Agonistic TNF-α Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander. Journal of Immunology (Baltimore, Md. : 1950). 206: 1740-1751. PMID 33782090 DOI: 10.4049/jimmunol.2000871   
2021 Tamargo-Gómez I, Martínez-García GG, Suárez MF, Rey V, Fueyo A, Codina-Martínez H, Bretones G, Caravia XM, Morel E, Dupont N, Cabo R, Tomás-Zapico C, Souquere S, Pierron G, Codogno P, et al. ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration. Cell Death and Differentiation. PMID 33795848 DOI: 10.1038/s41418-021-00776-1   
2021 Sharma N, Shandilya A, Kumar N, Mehan S. Dysregulation of SIRT-1 Signaling in Multiple Sclerosis and Neuroimmune Disorders: A Systematic Review on SIRTUIN Activators as Potential Immunomodulators and Influences on other Dysfunctions. Endocrine, Metabolic & Immune Disorders Drug Targets. PMID 33687904 DOI: 10.2174/1871530321666210309112234