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Morgan DeSantis - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zang JL, Gibson D, Zheng AM, Shi W, Gillies JP, Stein C, Drerup CM, DeSantis ME. CCSer2 gates dynein activity at the cell periphery. Biorxiv : the Preprint Server For Biology. PMID 38915497 DOI: 10.1101/2024.06.13.598865  0.802
2023 Badieyan S, Lichon D, Andreas MP, Gillies JP, Peng W, Shi J, DeSantis ME, Aiken CR, Böcking T, Giessen TW, Campbell EM, Cianfrocco MA. HIV-1 binds dynein directly to hijack microtubule transport machinery. Biorxiv : the Preprint Server For Biology. PMID 37693451 DOI: 10.1101/2023.08.29.555335  0.768
2023 Garrott SR, Gillies JP, Siva A, Little SR, El Jbeily R, DeSantis ME. Ndel1 disfavors dynein-dynactin-adaptor complex formation in two distinct ways. The Journal of Biological Chemistry. 104735. PMID 37086789 DOI: 10.1016/j.jbc.2023.104735  0.801
2023 He S, Gillies JP, Zang JL, Córdoba-Beldad CM, Yamamoto I, Fujiwara Y, Grantham J, DeSantis ME, Shibuya H. Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity. Nature Communications. 14: 1715. PMID 36973253 DOI: 10.1038/s41467-023-37370-7  0.779
2023 Garrott SR, DeSantis ME. CryoEM shows the active dynein complex on microtubules. Trends in Biochemical Sciences. 48: 315-316. PMID 36754682 DOI: 10.1016/j.tibs.2023.01.007  0.778
2023 Garrott SR, Gillies JP, Siva A, Little SR, El Jbeily R, DeSantis ME. Ndel1 modulates dynein activation in two distinct ways. Biorxiv : the Preprint Server For Biology. PMID 36747695 DOI: 10.1101/2023.01.25.525437  0.8
2023 Reimer JM, DeSantis ME, Reck-Peterson SL, Leschziner AE. Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. Elife. 12. PMID 36692009 DOI: 10.7554/eLife.84302  0.636
2022 Agrawal R, Gillies JP, Zang JL, Zhang J, Garrott SR, Shibuya H, Nandakumar J, DeSantis ME. The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor. Elife. 11. PMID 35703493 DOI: 10.7554/eLife.78201  0.781
2022 Garrott SR, Gillies JP, DeSantis ME. Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport. Frontiers in Cell and Developmental Biology. 10: 871935. PMID 35493069 DOI: 10.3389/fcell.2022.871935  0.784
2021 Triclin S, Inoue D, Gaillard J, Htet ZM, DeSantis ME, Portran D, Derivery E, Aumeier C, Schaedel L, John K, Leterrier C, Reck-Peterson SL, Blanchoin L, Théry M. Self-repair protects microtubules from destruction by molecular motors. Nature Materials. PMID 33479528 DOI: 10.1038/s41563-020-00905-0  0.625
2020 Htet ZM, Gillies JP, Baker RW, Leschziner AE, DeSantis ME, Reck-Peterson SL. LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes. Nature Cell Biology. PMID 32341549 DOI: 10.1038/S41556-020-0506-Z  0.82
2018 Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173: 677-692.e20. PMID 29677512 DOI: 10.1016/J.Cell.2018.03.002  0.764
2018 Htet ZM, DeSantis ME, Cianfrocco MA, Tran PT, Leschziner AE, Reck-Peterson SL. Two Opposing Modes of Cytoplasmic Dynein Regulation by Lis1 Biophysical Journal. 114: 512a. DOI: 10.1016/J.Bpj.2017.11.2797  0.729
2018 Reck-Peterson S, Leschziner A, DeSantis M, Cianfrocco M, Min Htet Z, Tien Tran P. Mechanisms of Regulating Cytoplasmic Dynein Biophysical Journal. 114: 9a. DOI: 10.1016/J.Bpj.2017.11.088  0.764
2017 DeSantis ME, Cianfrocco MA, Htet ZM, Tran PT, Reck-Peterson SL, Leschziner AE. Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 170: 1197-1208.e12. PMID 28886386 DOI: 10.1016/J.Cell.2017.08.037  0.792
2017 Redwine WB, DeSantis ME, Hollyer I, Htet ZM, Tran PT, Swanson SK, Florens L, Washburn MP, Reck-Peterson SL. The human cytoplasmic dynein interactome reveals novel activators of motility. Elife. 6. PMID 28718761 DOI: 10.7554/Elife.28257  0.668
2017 Cianfrocco MA, DeSantis ME, Htet ZM, Tran PT, Leschziner AE, Reck-Peterson SL. Lis1 has Two Distinct Modes of Regulating Dynein's Mechanochemical Cycle Biophysical Journal. 112: 43a. DOI: 10.1016/J.Bpj.2016.11.274  0.794
2015 Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL. Mechanism and Regulation of Cytoplasmic Dynein. Annual Review of Cell and Developmental Biology. PMID 26436706 DOI: 10.1146/Annurev-Cellbio-100814-125438  0.784
2015 Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J. The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Molecular Cell. 57: 836-49. PMID 25620563 DOI: 10.1016/J.Molcel.2014.12.021  0.8
2014 Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J. Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 156: 170-82. PMID 24439375 DOI: 10.1016/J.Cell.2013.11.047  0.81
2014 Desantis ME, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. The Journal of Biological Chemistry. 289: 848-67. PMID 24280225 DOI: 10.1074/Jbc.M113.520759  0.808
2013 Coelho M, Dereli A, Haese A, Kühn S, Malinovska L, DeSantis ME, Shorter J, Alberti S, Gross T, Tolić-Nørrelykke IM. Fission yeast does not age under favorable conditions, but does so after stress. Current Biology : Cb. 23: 1844-52. PMID 24035542 DOI: 10.1016/J.Cub.2013.07.084  0.409
2013 DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J. Inter-Subunit Coordination in Hsp104, a Protein Disaggregase Biophysical Journal. 104: 571a. DOI: 10.1016/J.Bpj.2012.11.3173  0.736
2013 Jackrel ME, DeSantis ME, Castellano LM, Shorter J. Potentiated Hsp104 Variants Antagonize Diverse Protein Misfolding Events Biophysical Journal. 104: 570a. DOI: 10.1016/j.bpj.2012.11.3167  0.779
2012 Desantis ME, Shorter J. Hsp104 drives "protein-only" positive selection of sup35 prion strains encoding strong [PSI+] Chemistry and Biology. 19: 1400-1410. PMID 23177195 DOI: 10.1016/J.Chembiol.2012.09.013  0.471
2012 DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J. Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. Cell. 151: 778-93. PMID 23141537 DOI: 10.1016/J.Cell.2012.09.038  0.736
2012 DeSantis ME, Shorter J. The elusive middle domain of Hsp104 and ClpB: Location and function Biochimica Et Biophysica Acta - Molecular Cell Research. 1823: 29-39. PMID 21843558 DOI: 10.1016/J.Bbamcr.2011.07.014  0.575
2011 Sweeny EA, DeSantis ME, Shorter J. Purification of hsp104, a protein disaggregase Journal of Visualized Experiments : Jove. PMID 21989490 DOI: 10.3791/3190  0.793
2009 Acchione M, Desantis M, Chien Y, Li M, Lipschultz C, Shanmuganathan A, Barchi J, Wlodawer A, Smith-Gill S. Structural Changes And Binding Kinetics Of Fluoro-tryptophan Substituted HyHEL-10 scFv Monitored Using 19F-NMR, High Resolution Crystal Structures And SPR-Biacore Analysis Biophysical Journal. 96: 548a. DOI: 10.1016/J.Bpj.2008.12.2967  0.345
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