Hugues Abriel - Publications

University of Bern, Bern, Bern, Switzerland 
ion channels, channelopathies

117 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wang Z, Vermij SH, Sottas V, Shestak A, Ross-Kaschitza D, Zaklyazminskaya EV, Hudmon A, Pitt GS, Rougier JS, Abriel H. Calmodulin binds to the N-terminal domain of the cardiac sodium channel Na1.5. Channels (Austin, Tex.). 14: 268-286. PMID 32815768 DOI: 10.1080/19336950.2020.1805999  1
2020 Vermij SH, Rougier JS, Agulló-Pascual E, Rothenberg E, Delmar M, Abriel H. Single-molecule Localization of Na1.5 Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains. Circulation. Arrhythmia and Electrophysiology. PMID 32536203 DOI: 10.1161/CIRCEP.119.008241  1
2020 Amarouch MY, Kurt H, Delemotte L, Abriel H. Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel Na1.5. Molecules (Basel, Switzerland). 25. PMID 32085432 DOI: 10.3390/molecules25040902  0.84
2019 Vermij SH, Abriel H, Kucera JP. Modeling Depolarization Delay, Sodium Currents, and Electrical Potentials in Cardiac Transverse Tubules. Frontiers in Physiology. 10: 1487. PMID 31920695 DOI: 10.3389/fphys.2019.01487  0.56
2019 Gillet L, Guichard S, Essers MC, Rougier JS, Abriel H. Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter. Scientific Reports. 9: 19422. PMID 31857666 DOI: 10.1038/s41598-019-55950-w  1
2019 Casini S, Albesa M, Wang Z, Portero V, Ross-Kaschitza D, Rougier JS, Marchal GA, Chung WK, Bezzina CR, Abriel H, Remme CA. Functional Consequences of the -p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice. International Journal of Molecular Sciences. 20. PMID 31614475 DOI: 10.3390/ijms20205033  1
2019 Neubauer J, Wang Z, Rougier JS, Abriel H, Rieubland C, Bartholdi D, Haas C, Medeiros-Domingo A. Functional characterization of a novel SCN5A variant associated with long QT syndrome and sudden cardiac death. International Journal of Legal Medicine. PMID 31455979 DOI: 10.1007/s00414-019-02141-x  1
2019 Rougier JS, Essers MC, Gillet L, Guichard S, Sonntag S, Shmerling D, Abriel H. A Distinct Pool of Na1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes. Frontiers in Physiology. 10: 834. PMID 31333492 DOI: 10.3389/fphys.2019.00834  1
2019 Vermij SH, Abriel H, Kucera JP. A fundamental evaluation of the electrical properties and function of cardiac transverse tubules. Biochimica Et Biophysica Acta. Molecular Cell Research. PMID 31269418 DOI: 10.1016/j.bbamcr.2019.06.016  0.56
2018 Chevalier M, Vermij SH, Wyler K, Gillet L, Keller I, Abriel H. Corrigendum: Transcriptomic analyses of murine ventricular cardiomyocytes. Scientific Data. 5: 180216. PMID 30299437 DOI: 10.1038/sdata.2018.216  0.64
2018 Tamo L, Hibaoui Y, Kallol S, Alves MP, Albrecht C, Hostettler KE, Feki A, Rougier JS, Abriel H, Knudsen L, Gazdhar A, Geiser T. Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30211653 DOI: 10.1152/ajplung.00357.2017  1
2018 Chevalier M, Vermij SH, Wyler K, Gillet L, Keller I, Abriel H. Transcriptomic analyses of murine ventricular cardiomyocytes. Scientific Data. 5: 180170. PMID 30129933 DOI: 10.1038/sdata.2018.170  0.64
2018 Neubauer J, Rougier JS, Abriel H, Haas C. Functional implications of a rare variant in the sodium channel β1B subunit () in a 5-month-old male sudden infant death syndrome case. Heartrhythm Case Reports. 4: 187-190. PMID 29915715 DOI: 10.1016/j.hrcr.2018.01.010  1
2017 Hichri E, Abriel H, Kucera JP. Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in the intercalated disc. The Journal of Physiology. PMID 29210458 DOI: 10.1113/JP275351  0.56
2017 Hinard V, Britan A, Schaeffer M, Zahn-Zabal M, Thomet U, Rougier JS, Bairoch A, Abriel H, Gaudet P. Annotation of functional impact of voltage-gated sodium channel mutations. Human Mutation. PMID 28168870 DOI: 10.1002/humu.23191  1
2016 Eichel CA, Beuriot A, Chevalier MY, Rougier JS, Louault F, Dilanian G, Amour J, Coulombe A, Abriel H, Hatem SN, Balse E. Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes. Circulation Research. 119: 544-56. PMID 27364017 DOI: 10.1161/CIRCRESAHA.116.309254  1
2016 Syam N, Chatel S, Ozhathil LC, Sottas V, Rougier JS, Baruteau A, Baron E, Amarouch MY, Daumy X, Probst V, Schott JJ, Abriel H. Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block. Journal of the American Heart Association. 5. PMID 27207958 DOI: 10.1161/JAHA.114.001625  1
2016 Amarouch MY, Swan H, Leinonen J, Marjamaa A, Lahtinen AM, Kontula K, Toivonen L, Widen E, Abriel H. Antiarrhythmic Action of Flecainide in Polymorphic Ventricular Arrhythmias Caused by a Gain-of-Function Mutation in the Nav 1.5 Sodium Channel. Annals of Noninvasive Electrocardiology : the Official Journal of the International Society For Holter and Noninvasive Electrocardiology, Inc. 21: 343-51. PMID 26965448 DOI: 10.1111/anec.12312  1
2016 Sottas V, Abriel H. Negative-dominance phenomenon with genetic variants of the cardiac sodium channel Nav1.5. Biochimica Et Biophysica Acta. 1863: 1791-8. PMID 26907222 DOI: 10.1016/j.bbamcr.2016.02.013  1
2016 Daumy X, Amarouch MY, Lindenbaum P, Bonnaud S, Charpentier E, Bianchi B, Nafzger S, Baron E, Fouchard S, Thollet A, Kyndt F, Barc J, Le Scouarnec S, Makita N, Le Marec H, ... ... Abriel H, et al. Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I. International Journal of Cardiology. 207: 349-58. PMID 26820365 DOI: 10.1016/j.ijcard.2016.01.052  1
2016 Rougier JS, Abriel H. Cardiac voltage-gated calcium channel macromolecular complexes. Biochimica Et Biophysica Acta. 1863: 1806-12. PMID 26707467 DOI: 10.1016/j.bbamcr.2015.12.014  1
2016 Daumy X, Amarouch MY, Lindenbaum P, Bonnaud S, Charpentier E, Bianchi B, Nafzger S, Baron E, Fouchard S, Thollet A, Kyndt F, Barc J, Le Scouarnec S, Makita N, Le Marec H, ... ... Abriel H, et al. Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type i International Journal of Cardiology. 207: 349-358. DOI: 10.1016/j.ijcard.2016.01.052  1
2015 Laedermann CJ, Abriel H, Decosterd I. Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. Frontiers in Pharmacology. 6: 263. PMID 26594175 DOI: 10.3389/fphar.2015.00263  1
2015 Abriel H, Rougier JS, Jalife J. Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death. Circulation Research. 116: 1971-88. PMID 26044251 DOI: 10.1161/CIRCRESAHA.116.305017  1
2015 Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, et al. Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of Physiology. 593: 1347-60. PMID 25772290 DOI: 10.1113/jphysiol.2014.281428  1
2015 Amarouch MY, Abriel H. Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels. Frontiers in Physiology. 6: 45. PMID 25741286 DOI: 10.3389/fphys.2015.00045  0.84
2015 Ossola D, Amarouch MY, Behr P, Vörös J, Abriel H, Zambelli T. Force-controlled patch clamp of beating cardiac cells. Nano Letters. 15: 1743-50. PMID 25639960 DOI: 10.1021/nl504438z  0.84
2015 Saber S, Amarouch MY, Fazelifar AF, Haghjoo M, Emkanjoo Z, Alizadeh A, Houshmand M, Gavrilenko AV, Abriel H, Zaklyazminskaya EV. Complex genetic background in a large family with Brugada syndrome. Physiological Reports. 3. PMID 25626866 DOI: 10.14814/phy2.12256  0.84
2015 Gillet L, Rougier JS, Shy D, Sonntag S, Mougenot N, Essers M, Shmerling D, Balse E, Hatem SN, Abriel H. Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 12: 181-92. PMID 25447080 DOI: 10.1016/j.hrthm.2014.09.057  1
2015 Rougier JS, Albesa M, Syam N, Halet G, Abriel H, Viard P. Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels. Pflugers Archiv : European Journal of Physiology. 467: 1919-29. PMID 25366495 DOI: 10.1007/s00424-014-1636-6  1
2015 Suter MR, Bhuiyan ZA, Laedermann CJ, Kuntzer T, Schaller M, Stauffacher MW, Roulet E, Abriel H, Decosterd I, Wider C. p.L1612P, a novel voltage-gated sodium channel Nav1.7 mutation inducing a cold sensitive paroxysmal extreme pain disorder. Anesthesiology. 122: 414-23. PMID 25285947 DOI: 10.1097/ALN.0000000000000476  1
2015 Amarouch MY, Swan H, Leinonen J, Marjamaa A, Lahtinen AM, Kontula K, Toivonen L, Widen E, Abriel H. Antiarrhythmic Action of Flecainide in Polymorphic Ventricular Arrhythmias Caused by a Gain-of-Function Mutation in the Nav1.5 Sodium Channel Annals of Noninvasive Electrocardiology. DOI: 10.1111/anec.12312  1
2014 Amarouch MY, Kasimova MA, Tarek M, Abriel H. Functional interaction between S1 and S4 segments in voltage-gated sodium channels revealed by human channelopathies. Channels (Austin, Tex.). 8: 414-20. PMID 25483584 DOI: 10.4161/19336950.2014.958922  0.84
2014 Shy D, Gillet L, Abriel H. Targeting the sodium channel NaV1.5 to specific membrane compartments of cardiac cells: not a simple task! Circulation Research. 115: 901-3. PMID 25378529 DOI: 10.1161/CIRCRESAHA.114.305305  1
2014 Gillet L, Shy D, Abriel H. Elucidating sodium channel NaV1.5 clustering in cardiac myocytes using super-resolution techniques. Cardiovascular Research. 104: 231-3. PMID 25341893 DOI: 10.1093/cvr/cvu221  1
2014 Swan H, Amarouch MY, Leinonen J, Marjamaa A, Kucera JP, Laitinen-Forsblom PJ, Lahtinen AM, Palotie A, Kontula K, Toivonen L, Abriel H, Widen E. Gain-of-function mutation of the SCN5A gene causes exercise-induced polymorphic ventricular arrhythmias. Circulation. Cardiovascular Genetics. 7: 771-81. PMID 25210054 DOI: 10.1161/CIRCGENETICS.114.000703  1
2014 Shy D, Gillet L, Ogrodnik J, Albesa M, Verkerk AO, Wolswinkel R, Rougier JS, Barc J, Essers MC, Syam N, Marsman RF, van Mil AM, Rotman S, Redon R, Bezzina CR, ... ... Abriel H, et al. PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function. Circulation. 130: 147-60. PMID 24895455 DOI: 10.1161/CIRCULATIONAHA.113.007852  1
2014 Laedermann CJ, Decosterd I, Abriel H. Ubiquitylation of voltage-gated sodium channels. Handbook of Experimental Pharmacology. 221: 231-50. PMID 24737239 DOI: 10.1007/978-3-642-41588-3_11  1
2014 Abriel H, Sottas V. Unexpected α-α interactions with NaV1.5 genetic variants in Brugada syndrome. Circulation. Cardiovascular Genetics. 7: 97-9. PMID 24736849 DOI: 10.1161/CIRCGENETICS.114.000590  1
2014 Syam N, Rougier JS, Abriel H. Glycosylation of TRPM4 and TRPM5 channels: molecular determinants and functional aspects. Frontiers in Cellular Neuroscience. 8: 52. PMID 24605085 DOI: 10.3389/fncel.2014.00052  1
2014 Clémençon B, Fine M, Lüscher B, Baumann MU, Surbek DV, Abriel H, Hediger MA. Expression, purification, and projection structure by single particle electron microscopy of functional human TRPM4 heterologously expressed in Xenopus laevis oocytes. Protein Expression and Purification. 95: 169-76. PMID 24333049 DOI: 10.1016/j.pep.2013.11.017  1
2014 Hersch M, Peter B, Kang HM, Schüpfer F, Abriel H, Pedrazzini T, Eskin E, Beckmann JS, Bergmann S, Maurer F. Correction: Mapping genetic variants associated with beta-adrenergic responses in inbred mice (PLoS ONE) Plos One. 9. DOI: 10.1371/annotation/16d5801b-2701-4ec9-9d8e-278791a8a26a  1
2013 Reinhard K, Rougier JS, Ogrodnik J, Abriel H. Electrophysiological properties of mouse and epitope-tagged human cardiac sodium channel Na v1.5 expressed in HEK293 cells. F1000research. 2: 48. PMID 24555036 DOI: 10.12688/f1000research.2-48.v2  1
2013 Abriel H, de Lange E, Kucera JP, Loussouarn G, Tarek M. Computational tools to investigate genetic cardiac channelopathies. Frontiers in Physiology. 4: 390. PMID 24421770 DOI: 10.3389/fphys.2013.00390  0.56
2013 Andersen MN, Krzystanek K, Petersen F, Bomholtz SH, Olesen SP, Abriel H, Jespersen T, Rasmussen HB. A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. The Journal of Biological Chemistry. 288: 36841-54. PMID 24214981 DOI: 10.1074/jbc.M113.525931  0.52
2013 Laedermann CJ, Syam N, Pertin M, Decosterd I, Abriel H. β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells. Frontiers in Cellular Neuroscience. 7: 137. PMID 24009557 DOI: 10.3389/fncel.2013.00137  1
2013 Abriel H, Rougier JS. β-blockers in congenital short-QT syndrome as ion channel blockers. Journal of Cardiovascular Electrophysiology. 24: 1172-4. PMID 23890274 DOI: 10.1111/jce.12204  1
2013 Gillet L, Shy D, Abriel H. NaV1.5 and interacting proteins in human arrhythmogenic cardiomyopathy. Future Cardiology. 9: 467-70. PMID 23834686 DOI: 10.2217/fca.13.38  1
2013 Laedermann CJ, Cachemaille M, Kirschmann G, Pertin M, Gosselin RD, Chang I, Albesa M, Towne C, Schneider BL, Kellenberger S, Abriel H, Decosterd I. Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain. The Journal of Clinical Investigation. 123: 3002-13. PMID 23778145 DOI: 10.1172/JCI68996  1
2013 Pérez López I, Cariolato L, Maric D, Gillet L, Abriel H, Diviani D. A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy. Molecular and Cellular Biology. 33: 2903-17. PMID 23716597 DOI: 10.1128/MCB.00031-13  0.64
2013 Sottas V, Rougier JS, Jousset F, Kucera JP, Shestak A, Makarov LM, Zaklyazminskaya EV, Abriel H. Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias. Journal of Cardiovascular Electrophysiology. 24: 1037-46. PMID 23692053 DOI: 10.1111/jce.12173  1
2013 Pouly D, Debonneville A, Ruffieux-Daidié D, Maillard M, Abriel H, Loffing J, Staub O. Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure. American Journal of Physiology. Renal Physiology. 305: F21-30. PMID 23552861 DOI: 10.1152/ajprenal.00012.2013  0.52
2013 Rougier JS, Gavillet B, Abriel H. Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx (5cv) mice. Frontiers in Physiology. 4: 51. PMID 23532763 DOI: 10.3389/fphys.2013.00051  1
2013 Amarouch MY, Syam N, Abriel H. Biochemical, single-channel, whole-cell patch clamp, and pharmacological analyses of endogenous TRPM4 channels in HEK293 cells. Neuroscience Letters. 541: 105-10. PMID 23428507 DOI: 10.1016/j.neulet.2013.02.011  1
2013 Liu H, Chatel S, Simard C, Syam N, Salle L, Probst V, Morel J, Millat G, Lopez M, Abriel H, Schott JJ, Guinamard R, Bouvagnet P. Molecular genetics and functional anomalies in a series of 248 Brugada cases with 11 mutations in the TRPM4 channel. Plos One. 8: e54131. PMID 23382873 DOI: 10.1371/journal.pone.0054131  1
2013 Abriel H, Zaklyazminskaya EV. Cardiac channelopathies: genetic and molecular mechanisms. Gene. 517: 1-11. PMID 23266818 DOI: 10.1016/j.gene.2012.12.061  0.56
2013 Suter MR, Kirschmann G, Laedermann CJ, Abriel H, Decosterd I. Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 118: 160-72. PMID 23221868 DOI: 10.1097/ALN.0b013e318278cade  1
2013 Shy D, Gillet L, Abriel H. Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: the multiple pool model. Biochimica Et Biophysica Acta. 1833: 886-94. PMID 23123192 DOI: 10.1016/j.bbamcr.2012.10.026  1
2012 Abriel H, Zaklyazminskaya EV. A modern approach to classify missense mutations in cardiac channelopathy genes. Circulation. Cardiovascular Genetics. 5: 487-9. PMID 23074335 DOI: 10.1161/CIRCGENETICS.112.964809  0.56
2012 Cachemaille M, Laedermann CJ, Pertin M, Abriel H, Gosselin RD, Decosterd I. Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain. Neuroscience. 227: 370-80. PMID 23022218 DOI: 10.1016/j.neuroscience.2012.09.044  1
2012 Rougier JS, Abriel H. Role of "non-cardiac" voltage-gated sodium channels in cardiac cells. Journal of Molecular and Cellular Cardiology. 53: 589-90. PMID 22967322 DOI: 10.1016/j.yjmcc.2012.08.011  1
2012 Rougier JS, Abriel H. Unexpected dominance: Brugada syndrome SCN5A variants exert negative dominance via α-subunit interaction. Cardiovascular Research. 96: 1-3. PMID 22871588 DOI: 10.1093/cvr/cvs264  1
2012 Hersch M, Peter B, Kang HM, Schüpfer F, Abriel H, Pedrazzini T, Eskin E, Beckmann JS, Bergmann S, Maurer F. Mapping genetic variants associated with beta-adrenergic responses in inbred mice. Plos One. 7: e41032. PMID 22859963 DOI: 10.1371/journal.pone.0041032  1
2012 Balse E, Steele DF, Abriel H, Coulombe A, Fedida D, Hatem SN. Dynamic of ion channel expression at the plasma membrane of cardiomyocytes. Physiological Reviews. 92: 1317-58. PMID 22811429 DOI: 10.1152/physrev.00041.2011  1
2012 Abriel H, Syam N, Sottas V, Amarouch MY, Rougier JS. TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology. Biochemical Pharmacology. 84: 873-81. PMID 22750058 DOI: 10.1016/j.bcp.2012.06.021  1
2012 Zaklyazminskaya EV, Abriel H. Prevalence of Significant Genetic Variants in Congenital Long QT Syndrome is Largely Underestimated. Frontiers in Pharmacology. 3: 72. PMID 22557970 DOI: 10.3389/fphar.2012.00072  0.56
2012 Krzystanek K, Rasmussen HB, Grunnet M, Staub O, Olesen SP, Abriel H, Jespersen T. Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 440-8. PMID 22024150 DOI: 10.1016/j.hrthm.2011.10.026  0.52
2011 Sintra Grilo L, Carrupt PA, Abriel H, Daina A. Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization. European Journal of Medicinal Chemistry. 46: 3486-98. PMID 21624711 DOI: 10.1016/j.ejmech.2011.05.015  0.52
2011 Grilo LS, Schläpfer J, Fellmann F, Abriel H. Patient with syncope and LQTS carrying a mutation in the PAS domain of the hERG1 channel. Annals of Noninvasive Electrocardiology : the Official Journal of the International Society For Holter and Noninvasive Electrocardiology, Inc. 16: 213-8. PMID 21496174 DOI: 10.1111/j.1542-474X.2011.00419.x  0.92
2011 Albesa M, Grilo LS, Gavillet B, Abriel H. Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1. Journal of Molecular and Cellular Cardiology. 51: 90-8. PMID 21463633 DOI: 10.1016/j.yjmcc.2011.03.015  1
2011 Templin C, Ghadri JR, Rougier JS, Baumer A, Kaplan V, Albesa M, Sticht H, Rauch A, Puleo C, Hu D, Barajas-Martinez H, Antzelevitch C, Lüscher TF, Abriel H, Duru F. Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6). European Heart Journal. 32: 1077-88. PMID 21383000 DOI: 10.1093/eurheartj/ehr076  1
2011 Rougier JS, Albesa M, Abriel H, Viard P. Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels. The Journal of Biological Chemistry. 286: 8829-38. PMID 21220429 DOI: 10.1074/jbc.M110.166520  1
2011 Petitprez S, Zmoos AF, Ogrodnik J, Balse E, Raad N, El-Haou S, Albesa M, Bittihn P, Luther S, Lehnart SE, Hatem SN, Coulombe A, Abriel H. SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. Circulation Research. 108: 294-304. PMID 21164104 DOI: 10.1161/CIRCRESAHA.110.228312  1
2011 Albesa M, Ogrodnik J, Rougier JS, Abriel H. Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice. Cardiovascular Research. 89: 320-8. PMID 20952415 DOI: 10.1093/cvr/cvq326  1
2010 Grilo LS, Carrupt PA, Abriel H. Stereoselective Inhibition of the hERG1 Potassium Channel. Frontiers in Pharmacology. 1: 137. PMID 21833176 DOI: 10.3389/fphar.2010.00137  0.92
2010 Pignier C, Rougier JS, Vié B, Culié C, Verscheure Y, Vacher B, Abriel H, Le Grand B. Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias. British Journal of Pharmacology. 161: 79-91. PMID 20718741 DOI: 10.1111/j.1476-5381.2010.00884.x  1
2010 Rougier JS, Albesa M, Abriel H. Ubiquitylation and SUMOylation of cardiac ion channels. Journal of Cardiovascular Pharmacology. 56: 22-8. PMID 20224423 DOI: 10.1097/FJC.0b013e3181daaff9  1
2010 Leoni AL, Gavillet B, Rougier JS, Marionneau C, Probst V, Le Scouarnec S, Schott JJ, Demolombe S, Bruneval P, Huang CL, Colledge WH, Grace AA, Le Marec H, Wilde AA, Mohler PJ, ... ... Abriel H, et al. Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model. Plos One. 5: e9298. PMID 20174578 DOI: 10.1371/journal.pone.0009298  1
2010 Grilo LS, Pruvot E, Grobéty M, Castella V, Fellmann F, Abriel H. Takotsubo cardiomyopathy and congenital long QT syndrome in a patient with a novel duplication in the Per-Arnt-Sim (PAS) domain of hERG1. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 7: 260-5. PMID 20004623 DOI: 10.1016/j.hrthm.2009.09.026  0.92
2010 Stirnimann G, Petitprez S, Abriel H, Schwick NG. Brugada syndrome ECG provoked by the selective serotonin reuptake inhibitor fluvoxamine. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 12: 282-3. PMID 19875396 DOI: 10.1093/europace/eup332  1
2009 Michaud K, Fellmann F, Abriel H, Beckmann JS, Mangin P, Elger BS. Molecular autopsy in sudden cardiac death and its implication for families: discussion of the practical, legal and ethical aspects of the multidisciplinary collaboration. Swiss Medical Weekly. 139: 712-8. PMID 20047134  1
2009 Berthonneche C, Peter B, Schüpfer F, Hayoz P, Kutalik Z, Abriel H, Pedrazzini T, Beckmann JS, Bergmann S, Maurer F. Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains. Plos One. 4: e6610. PMID 19672458 DOI: 10.1371/journal.pone.0006610  1
2009 Kurokawa J, Abriel H. Neurohormonal regulation of cardiac ion channels in chronic heart failure. Journal of Cardiovascular Pharmacology. 54: 98-105. PMID 19597366 DOI: 10.1097/FJC.0b013e3181b2b6d4  0.6
2009 Tfelt-Hansen J, Jespersen T, Hofman-Bang J, Rasmussen HB, Cedergreen P, Skovby F, Abriel H, Svendsen JH, Olesen SP, Christiansen M, Haunso S. Ventricular tachycardia in a Brugada syndrome patient caused by a novel deletion in SCN5A. The Canadian Journal of Cardiology. 25: 156-60. PMID 19279983 DOI: 10.1016/S0828-282X(09)70043-1  0.52
2009 El-Haou S, Balse E, Neyroud N, Dilanian G, Gavillet B, Abriel H, Coulombe A, Jeromin A, Hatem SN. Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. Circulation Research. 104: 758-69. PMID 19213956 DOI: 10.1161/CIRCRESAHA.108.191007  1
2008 Petitprez S, Tiab L, Chen L, Kappeler L, Rösler KM, Schorderet D, Abriel H, Burgunder JM. A novel dominant mutation of the Nav1.4 alpha-subunit domain I leading to sodium channel myotonia. Neurology. 71: 1669-75. PMID 19015483 DOI: 10.1212/01.wnl.0000335168.86248.55  1
2008 Petitprez S, Abriel H. Crosstalk between cardiac ion channel subunits: an encrypted language to be deciphered. Journal of Molecular and Cellular Cardiology. 45: 333-5. PMID 18582471 DOI: 10.1016/j.yjmcc.2008.05.019  1
2008 Grilo LS, Abriel H. Male and female equality: still far from goal. The Journal of Physiology. 586: 2825-6. PMID 18556724 DOI: 10.1113/jphysiol.2008.156398  0.92
2008 Petitprez S, Jespersen T, Pruvot E, Keller DI, Corbaz C, Schläpfer J, Abriel H, Kucera JP. Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome. Cardiovascular Research. 78: 494-504. PMID 18252757 DOI: 10.1093/cvr/cvn023  1
2008 Petitprez S, Abriel H. Effects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 10: 257; author reply 25. PMID 18056137 DOI: 10.1093/europace/eum266  1
2008 Rougier JS, Muller O, Berger S, Centeno G, Schütz G, Firsov D, Abriel H. Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes. PflüGers Archiv : European Journal of Physiology. 456: 407-12. PMID 18040710 DOI: 10.1007/s00424-007-0387-z  1
2007 Kranjcec D, Bergovec M, Rougier JS, Raguz M, Pavlovic S, Jespersen T, Castella V, Keller DI, Abriel H. Brugada syndrome unmasked by accidental inhalation of gasoline vapors. Pacing and Clinical Electrophysiology : Pace. 30: 1294-8. PMID 17897138 DOI: 10.1111/j.1540-8159.2007.00857.x  1
2007 Jespersen T, Membrez M, Nicolas CS, Pitard B, Staub O, Olesen SP, Baró I, Abriel H. The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovascular Research. 74: 64-74. PMID 17289006 DOI: 10.1016/j.cardiores.2007.01.008  0.52
2007 Domenighetti AA, Boixel C, Cefai D, Abriel H, Pedrazzini T. Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation. Journal of Molecular and Cellular Cardiology. 42: 63-70. PMID 17070838 DOI: 10.1016/j.yjmcc.2006.09.019  1
2006 Jespersen T, Gavillet B, van Bemmelen MX, Cordonier S, Thomas MA, Staub O, Abriel H. Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1. Biochemical and Biophysical Research Communications. 348: 1455-62. PMID 16930557 DOI: 10.1016/j.bbrc.2006.08.014  1
2006 Gavillet B, Rougier JS, Domenighetti AA, Behar R, Boixel C, Ruchat P, Lehr HA, Pedrazzini T, Abriel H. Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin Circulation Research. 99: 407-414. PMID 16857961 DOI: 10.1161/01.RES.0000237466.13252.5e  1
2006 Fodstad H, Bendahhou S, Rougier JS, Laitinen-Forsblom PJ, Barhanin J, Abriel H, Schild L, Kontula K, Swan H. Molecular characterization of two founder mutations causing long QT syndrome and identification of compound heterozygous patients. Annals of Medicine. 38: 294-304. PMID 16754261 DOI: 10.1080/07853890600756065  1
2006 Camacho JA, Hensellek S, Rougier JS, Blechschmidt S, Abriel H, Benndorf K, Zimmer T. Modulation of Nav1.5 channel function by an alternatively spliced sequence in the DII/DIII linker region. The Journal of Biological Chemistry. 281: 9498-506. PMID 16469732 DOI: 10.1074/jbc.M509716200  1
2006 Boixel C, Gavillet B, Rougier JS, Abriel H. Aldosterone increases voltage-gated sodium current in ventricular myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 290: H2257-66. PMID 16428353 DOI: 10.1152/ajpheart.01060.2005  1
2005 Abriel H, Staub O. Ubiquitylation of ion channels. Physiology (Bethesda, Md.). 20: 398-407. PMID 16287989 DOI: 10.1152/physiol.00033.2005  0.52
2005 Keller DI, Rougier JS, Kucera JP, Benammar N, Fressart V, Guicheney P, Madle A, Fromer M, Schläpfer J, Abriel H. Brugada syndrome and fever: genetic and molecular characterization of patients carrying SCN5A mutations. Cardiovascular Research. 67: 510-9. PMID 15890323 DOI: 10.1016/j.cardiores.2005.03.024  1
2005 Abriel H, Kass RS. Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins. Trends in Cardiovascular Medicine. 15: 35-40. PMID 15795161 DOI: 10.1016/j.tcm.2005.01.001  1
2005 Rougier JS, van Bemmelen MX, Bruce MC, Jespersen T, Gavillet B, Apothéloz F, Cordonier S, Staub O, Rotin D, Abriel H. Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. American Journal of Physiology. Cell Physiology. 288: C692-701. PMID 15548568 DOI: 10.1152/ajpcell.00460.2004  1
2004 Abriel H, Schläpfer J, Keller DI, Gavillet B, Buclin T, Biollaz J, Stoller R, Kappenberger L. Molecular and clinical determinants of drug-induced long QT syndrome: an iatrogenic channelopathy. Swiss Medical Weekly. 134: 685-94. PMID 15616901  1
2004 Le Bouter S, El Harchi A, Marionneau C, Bellocq C, Chambellan A, van Veen T, Boixel C, Gavillet B, Abriel H, Le Quang K, Chevalier JC, Lande G, Léger JJ, Charpentier F, Escande D, et al. Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation. 110: 3028-35. PMID 15520326 DOI: 10.1161/01.CIR.0000147187.78162.AC  1
2004 van Bemmelen MX, Rougier JS, Gavillet B, Apothéloz F, Daidié D, Tateyama M, Rivolta I, Thomas MA, Kass RS, Staub O, Abriel H. Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. Circulation Research. 95: 284-91. PMID 15217910 DOI: 10.1161/01.RES.0000136816.05109.89  1
2004 Blot V, Perugi F, Gay B, Prévost MC, Briant L, Tangy F, Abriel H, Staub O, Dokhélar MC, Pique C. Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding. Journal of Cell Science. 117: 2357-67. PMID 15126635 DOI: 10.1242/jcs.01095  0.52
2002 Liu H, Tateyama M, Clancy CE, Abriel H, Kass RS. Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations. The Journal of General Physiology. 120: 39-51. PMID 12084774 DOI: 10.1085/jgp.20028558  1
2001 Rivolta I, Abriel H, Tateyama M, Liu H, Memmi M, Vardas P, Napolitano C, Priori SG, Kass RS. Inherited Brugada and long QT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes. The Journal of Biological Chemistry. 276: 30623-30. PMID 11410597 DOI: 10.1074/jbc.M104471200  1
2001 Kurokawa J, Abriel H, Kass RS. Molecular basis of the delayed rectifier current I(ks)in heart. Journal of Molecular and Cellular Cardiology. 33: 873-82. PMID 11343411 DOI: 10.1006/jmcc.2001.1377  1
2001 Abriel H, Cabo C, Wehrens XH, Rivolta I, Motoike HK, Memmi M, Napolitano C, Priori SG, Kass RS. Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel. Circulation Research. 88: 740-5. PMID 11304498 DOI: 10.1161/HH0701.089668  1
2001 Dhar Malhotra J, Chen C, Rivolta I, Abriel H, Malhotra R, Mattei LN, Brosius FC, Kass RS, Isom LL. Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. Circulation. 103: 1303-10. PMID 11238277 DOI: 10.1161/01.CIR.103.9.1303  1
2000 Abriel H, Wehrens XH, Benhorin J, Kerem B, Kass RS. Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome. Circulation. 102: 921-5. PMID 10952963 DOI: 10.1161/01.CIR.102.8.921  1
2000 Wehrens XH, Abriel H, Cabo C, Benhorin J, Kass RS. Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysis. Circulation. 102: 584-90. PMID 10920073 DOI: 10.1161/01.CIR.102.5.584  1
2000 Abriel H, Motoike H, Kass RS. KChAP: a novel chaperone for specific K(+) channels key to repolarization of the cardiac action potential. Focus on "KChAP as a chaperone for specific K(+) channels". American Journal of Physiology. Cell Physiology. 278: C863-4. PMID 10794658 DOI: 10.1152/AJPCELL.2000.278.5.C863  1
2000 Staub O, Abriel H, Plant P, Ishikawa T, Kanelis V, Saleki R, Horisberger JD, Schild L, Rotin D. Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination. Kidney International. 57: 809-15. PMID 10720933 DOI: 10.1046/j.1523-1755.2000.00919.x  1
1999 Abriel H, Loffing J, Rebhun JF, Pratt JH, Schild L, Horisberger JD, Rotin D, Staub O. Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome. The Journal of Clinical Investigation. 103: 667-73. PMID 10074483 DOI: 10.1172/JCI5713  1
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