| Year |
Citation |
Score |
| 2020 |
Ahuja AS, Selvam P, Vadlamudi C, Chopra H, Richter JE, Macklin SK, Samreen A, Helmi H, Mohammaad AN, Hines S, Davila MC, Atwal PS, Caulfield TR. Genomics combined with a protein informatics platform to assess a novel pathogenic variant c.1024 A>G (p.K342E) in OPA1 in a patient with autosomal dominant optic atrophy. Ophthalmic Genetics. 1-7. PMID 32940104 DOI: 10.1080/13816810.2020.1814344 |
0.326 |
|
| 2020 |
Macklin SK, Bruno KA, Vadlamudi C, Helmi H, Samreen A, Mohammad AN, Hines S, Atwal PS, Caulfield TR. Examination of Molecular Effects of Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction. Case Reports in Medicine. 2020: 5108052. PMID 32655646 DOI: 10.1155/2020/5108052 |
0.311 |
|
| 2020 |
Kojima Y, Machida Y, Palani S, Caulfield TR, Radisky ES, Kaufmann SH, Machida YJ. FAM111A protects replication forks from protein obstacles via its trypsin-like domain. Nature Communications. 11: 1318. PMID 32165630 DOI: 10.1038/S41467-020-15170-7 |
0.312 |
|
| 2020 |
Coban M, Fraga S, Caulfield T. Structural and Computational Perspectives of Selectively Targeting Mutant Proteins. Current Drug Discovery Technologies. PMID 32160847 DOI: 10.2174/1570163817666200311114819 |
0.339 |
|
| 2020 |
Richter JE, Vadlamudi C, Macklin SK, Samreen A, Helmi H, Broderick D, Mohammad AN, Hines SL, VanGerpen JA, Atwal PS, Caulfield TR. Characterization of a Pathogenic Variant in the ABCD1 Gene Through Protein Molecular Modeling. Case Reports in Genetics. 2020: 3256539. PMID 32047678 DOI: 10.1155/2020/3256539 |
0.3 |
|
| 2019 |
Cohen I, Coban M, Shahar A, Sankaran B, Hockla A, Lacham S, Caulfield TR, Radisky ES, Papo N. Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. The Journal of Biological Chemistry. PMID 30700553 DOI: 10.1074/Jbc.Ra118.007292 |
0.331 |
|
| 2018 |
Macklin S, Mohammed A, Jackson J, Hines SL, Atwal PS, Caulfield T. Personalized molecular modeling for pinpointing associations of protein dysfunction and variants associated with hereditary cancer syndromes. Molecular Genetics & Genomic Medicine. PMID 30043523 DOI: 10.1002/Mgg3.447 |
0.322 |
|
| 2018 |
Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, et al. Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity. Cell Reports. 24: 529-537.e4. PMID 30021151 DOI: 10.1016/J.Celrep.2018.06.070 |
0.335 |
|
| 2018 |
Richter JE, Robles HG, Mauricio E, Mohammad A, Atwal PS, Caulfield TR. Protein molecular modeling shows residue T599 is critical to wild-type function of POLG and description of a novel variant associated with the SANDO phenotype. Human Genome Variation. 5: 18016. PMID 29644085 DOI: 10.1038/Hgv.2018.16 |
0.361 |
|
| 2018 |
ANDO M, FIESEL FC, HUDEC R, CAULFIELD TR, OGAKI K, GÓRKA-SKOCZYLAS P, KOZIOROWSKI D, FRIEDMAN A, CHEN L, DAWSON VL, DAWSON TM, BU G, ROSS OA, WSZOLEK ZK, SPRINGER W. The PINK1 p.I368N Mutation Affects Protein Stability and Kinase Activity with Its Structural Change Juntendo Medical Journal. 64: 17-30. DOI: 10.14789/Jmj.2018.64.Jmjjmj17-R10 |
0.31 |
|
| 2017 |
Paulus A, Akhtar S, Yousaf H, Manna A, Paulus SM, Bashir Y, Caulfield TR, Kuranz-Blake M, Chitta K, Wang X, Asmann Y, Hudec R, Springer W, Ailawadhi S, Chanan-Khan A. Waldenstrom macroglobulinemia cells devoid of BTK(C481S) or CXCR4(WHIM-like) mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment. Blood Cancer Journal. 7: e565. PMID 28548645 DOI: 10.1038/Bcj.2017.40 |
0.302 |
|
| 2017 |
Kayode O, Huang Z, Soares AS, Caulfield TR, Dong Z, Bode AM, Radisky ES. Small molecule inhibitors of mesotrypsin from a structure-based docking screen. Plos One. 12: e0176694. PMID 28463992 DOI: 10.1371/Journal.Pone.0176694 |
0.307 |
|
| 2017 |
Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W. The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity. Molecular Neurodegeneration. 12: 32. PMID 28438176 DOI: 10.1186/S13024-017-0174-Z |
0.384 |
|
| 2016 |
Truban D, Hou X, Caulfield TR, Fiesel FC, Springer W. PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology? Journal of Parkinson's Disease. PMID 27911343 DOI: 10.3233/Jpd-160989 |
0.311 |
|
| 2016 |
Kayode O, Wang R, Pendlebury DF, Cohen I, Henin RD, Hockla A, Soares AS, Papo N, Caulfield TR, Radisky ES. An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis. The Journal of Biological Chemistry. PMID 27810896 DOI: 10.1074/Jbc.M116.758417 |
0.312 |
|
| 2016 |
Puschmann A, Fiesel FC, Caulfield TR, Hudec R, Ando M, Truban D, Hou X, Ogaki K, Heckman MG, James ED, Swanberg M, Jimenez-Ferrer I, Hansson O, Opala G, Siuda J, et al. Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism. Brain : a Journal of Neurology. PMID 27807026 DOI: 10.1093/Brain/Aww261 |
0.326 |
|
| 2015 |
Fiesel FC, Ando M, Hudec R, Hill AR, Castanedes-Casey M, Caulfield TR, Moussaud-Lamodière EL, Stankowski JN, Bauer PO, Lorenzo-Betancor O, Ferrer I, Arbelo JM, Siuda J, Chen L, Dawson VL, et al. (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation. Embo Reports. PMID 26162776 DOI: 10.15252/Embr.201540514 |
0.355 |
|
| 2015 |
Fiesel FC, Caulfield TR, Moussaud-Lamodière EL, Ogaki K, Dourado DF, Flores SC, Ross OA, Springer W. Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin. Human Mutation. 36: 774-86. PMID 25939424 DOI: 10.1002/Humu.22808 |
0.38 |
|
| 2015 |
Wang X, D'Arcy P, Caulfield TR, Paulus A, Chitta K, Mohanty C, Gullbo J, Chanan-Khan A, Linder S. Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15. Chemical Biology & Drug Design. PMID 25854145 DOI: 10.1111/Cbdd.12571 |
0.316 |
|
| 2015 |
Caulfield TR, Fiesel FC, Springer W. Activation of the E3 ubiquitin ligase Parkin. Biochemical Society Transactions. 43: 269-74. PMID 25849928 DOI: 10.1042/Bst20140321 |
0.36 |
|
| 2015 |
Chitta K, Paulus A, Akhtar S, Blake MK, Caulfield TR, Novak AJ, Ansell SM, Advani P, Ailawadhi S, Sher T, Linder S, Chanan-Khan A. Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells. British Journal of Haematology. 169: 377-90. PMID 25691154 DOI: 10.1111/Bjh.13304 |
0.301 |
|
| 2014 |
Caulfield TR, Fiesel FC, Moussaud-Lamodière EL, Dourado DF, Flores SC, Springer W. Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin. Plos Computational Biology. 10: e1003935. PMID 25375667 DOI: 10.1371/Journal.Pcbi.1003935 |
0.408 |
|
| 2014 |
Zhang YJ, Jansen-West K, Xu YF, Gendron TF, Bieniek KF, Lin WL, Sasaguri H, Caulfield T, Hubbard J, Daughrity L, Chew J, Belzil VV, Prudencio M, Stankowski JN, Castanedes-Casey M, et al. Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress. Acta Neuropathologica. 128: 505-24. PMID 25173361 DOI: 10.1007/S00401-014-1336-5 |
0.323 |
|
| 2013 |
Gendron TF, Bieniek KF, Zhang YJ, Jansen-West K, Ash PE, Caulfield T, Daughrity L, Dunmore JH, Castanedes-Casey M, Chew J, Cosio DM, van Blitterswijk M, Lee WC, Rademakers R, Boylan KB, et al. Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS. Acta Neuropathologica. 126: 829-44. PMID 24129584 DOI: 10.1007/S00401-013-1192-8 |
0.319 |
|
| 2013 |
Zhang YJ, Caulfield T, Xu YF, Gendron TF, Hubbard J, Stetler C, Sasaguri H, Whitelaw EC, Cai S, Lee WC, Petrucelli L. The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation. Human Molecular Genetics. 22: 3112-22. PMID 23575225 DOI: 10.1093/Hmg/Ddt166 |
0.322 |
|
| 2013 |
Batra J, Szabó A, Caulfield TR, Soares AS, Sahin-Tóth M, Radisky ES. Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation. The Journal of Biological Chemistry. 288: 9848-59. PMID 23430245 DOI: 10.1074/Jbc.M113.457382 |
0.314 |
|
| 2013 |
Roemeling CAv, Marlow L, Caulfield T, Wu K, Tan W, Tun H, Copland JA, Mathias A, Harrison C, Dawson L, Hollister B. Abstract LB-210: Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-210 |
0.317 |
|
| 2012 |
Caulfield T, Devkota B. Motion of transfer RNA from the A/T state into the A-site using docking and simulations. Proteins. 80: 2489-500. PMID 22730134 DOI: 10.1002/Prot.24131 |
0.646 |
|
| 2011 |
Caulfield TR, Devkota B, Rollins GC. Examinations of tRNA Range of Motion Using Simulations of Cryo-EM Microscopy and X-Ray Data. Journal of Biophysics (Hindawi Publishing Corporation : Online). 2011: 219515. PMID 21716650 DOI: 10.1155/2011/219515 |
0.632 |
|
| 2011 |
Caulfield TR. Inter-ring rotation of apolipoprotein A-I protein monomers for the double-belt model using biased molecular dynamics. Journal of Molecular Graphics & Modelling. 29: 1006-14. PMID 21570882 DOI: 10.1016/J.Jmgm.2011.04.005 |
0.315 |
|
| 2006 |
Mears JA, Sharma MR, Gutell RR, McCook AS, Richardson PE, Caulfield TR, Agrawal RK, Harvey SC. A structural model for the large subunit of the mammalian mitochondrial ribosome. Journal of Molecular Biology. 358: 193-212. PMID 16510155 DOI: 10.1016/J.Jmb.2006.01.094 |
0.662 |
|
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