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Keriann M. Backus - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Chemical Biology
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Julio AR, Shikwana F, Truong C, Burton NR, Dominguez E, Turmon AC, Cao J, Backus K. Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds. Biorxiv : the Preprint Server For Biology. PMID 38014036 DOI: 10.1101/2023.10.30.564067  0.328
2023 Yan T, Boatner LM, Cui L, Tontonoz P, Backus KM. Defining the Cell Surface Cysteinome using Two-step Enrichment Proteomics. Biorxiv : the Preprint Server For Biology. PMID 37904933 DOI: 10.1101/2023.10.17.562832  0.301
2023 Khan RMN, Ahn YM, Marriner GA, Via LE, D'Hooge F, Lee SS, Yang N, Basuli F, White AG, Tomko JA, Frye LJ, Scanga CA, Weiner DM, Sutphen ML, Schimel DM, ... ... Backus KM, et al. Distributable, Metabolic PET Reporting of Tuberculosis. Biorxiv : the Preprint Server For Biology. PMID 37333343 DOI: 10.1101/2023.04.03.535218  0.39
2020 Xu JH, Eberhardt J, Hill-Payne B, Gonzalez-Paez GE, Castellón JO, Cravatt BF, Forli S, Wolan DW, Backus KM. Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity. Acs Chemical Biology. PMID 31927936 DOI: 10.1021/Acschembio.0C00019  0.502
2019 Backus KM, Cao J, Maddox SM. Opportunities and challenges for the development of covalent chemical immunomodulators. Bioorganic & Medicinal Chemistry. PMID 31204229 DOI: 10.1016/J.Bmc.2019.05.050  0.432
2018 Backus KM. Applications of Reactive Cysteine Profiling. Current Topics in Microbiology and Immunology. PMID 30105421 DOI: 10.1007/82_2018_120  0.415
2017 Hacker SM, Backus KM, Lazear MR, Forli S, Correia BE, Cravatt BF. Global profiling of lysine reactivity and ligandability in the human proteome. Nature Chemistry. 9: 1181-1190. PMID 29168484 DOI: 10.1038/Nchem.2826  0.564
2017 Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. PMID 28965760 DOI: 10.1016/J.Cell.2017.08.051  0.639
2017 Touchette MH, Van Vlack E, Bai L, Kim J, Cognetta AB, Previti ML, Backus KM, Martin DW, Cravatt BF, Seeliger JC. A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link Between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. Acs Infectious Diseases. PMID 28276676 DOI: 10.1021/Acsinfecdis.6B00179  0.483
2017 Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. PMID 28111075 DOI: 10.1016/J.Cell.2016.12.021  0.457
2016 Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C. Covalent Modulators of the Vacuolar ATPase. Journal of the American Chemical Society. PMID 28010062 DOI: 10.1021/Jacs.6B12511  0.494
2016 Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF. Chemical Proteomic Profiling of Human Methyltransferases. Journal of the American Chemical Society. PMID 27689866 DOI: 10.1021/Jacs.6B07830  0.635
2016 Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells. Science Signaling. 9: rs10. PMID 27625306 DOI: 10.1126/Scisignal.Aaf7694  0.637
2016 Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell. 166: 126-139. PMID 27368101 DOI: 10.1016/J.Cell.2016.05.042  0.397
2016 Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF. Proteome-wide covalent ligand discovery in native biological systems. Nature. PMID 27309814 DOI: 10.1038/Nature18002  0.537
2014 Backus KM, Dolan MA, Barry CS, Joe M, McPhie P, Boshoff HI, Lowary TL, Davis BG, Barry CE. The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions. The Journal of Biological Chemistry. 289: 25041-53. PMID 25028517 DOI: 10.1074/Jbc.M114.581579  0.528
2011 Barry CS, Backus KM, Barry CE, Davis BG. ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor. Journal of the American Chemical Society. 133: 13232-5. PMID 21776980 DOI: 10.1021/Ja204249P  0.524
2011 Backus KM, Boshoff HI, Barry CS, Boutureira O, Patel MK, D'Hooge F, Lee SS, Via LE, Tahlan K, Barry CE, Davis BG. Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis. Nature Chemical Biology. 7: 228-35. PMID 21378984 DOI: 10.1038/Nchembio.539  0.484
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