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David C. Leitch, Ph. D. - Publications

Affiliations: 
2014-2018 Process Chemistry GlaxoSmithKline Pharmaceuticals R&D 
 2019- Chemistry University of Victoria, Victoria, British Columbia, Canada 
Area:
Organometallic Chemistry, Catalysis
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Huang J, Keenan T, Richard F, Lu J, Jenny SE, Jean A, Arseniyadis S, Leitch DC. Chiral, air stable, and reliable Pd(0) precatalysts applicable to asymmetric allylic alkylation chemistry. Nature Communications. 14: 8058. PMID 38052843 DOI: 10.1038/s41467-023-43512-8  0.402
2022 Dhake K, Woelk KJ, Becica J, Un A, Jenny SE, Leitch DC. Beyond Bioisosteres: Divergent Synthesis of Azabicyclohexanes and Cyclobutenyl Amines from Bicyclobutanes. Angewandte Chemie (International Ed. in English). PMID 35442565 DOI: 10.1002/anie.202204719  0.778
2022 Lu J, Donnecke S, Paci I, Leitch DC. A reactivity model for oxidative addition to palladium enables quantitative predictions for catalytic cross-coupling reactions. Chemical Science. 13: 3477-3488. PMID 35432873 DOI: 10.1039/d2sc00174h  0.324
2020 Lim JJ, Dixon F, Leitch DC, Kowalski J, Nilson M, Goss C, Flanagan R, Hayes S, Murphy MJ. Playing with Fire? A Safe and Effective Deactivation of Raney Cobalt using Aqueous Sodium Nitrate Organic Process Research & Development. 24: 1180-1184. DOI: 10.1021/Acs.Oprd.0C00053  0.363
2019 Becica J, Hruszkewycz DP, Steves JE, Elward JM, Leitch DC, Dobereiner GE. High-Throughput Discovery and Evaluation of a General Catalytic Method for -Arylation of Weakly Nucleophilic Sulfonamides. Organic Letters. PMID 31651171 DOI: 10.1021/Acs.Orglett.9B03380  0.442
2019 Egbert JD, Thomsen EC, O’Neill-Slawecki SA, Mans DM, Leitch DC, Edwards LJ, Wade CE, Weber RS. Development and Scale-up of Continuous Electrocatalytic Hydrogenation of Functionalized Nitro Arenes, Nitriles, and Unsaturated Aldehydes Organic Process Research & Development. 23: 1803-1812. DOI: 10.1021/Acs.Oprd.8B00379  0.34
2018 Arrington K, Barcan GA, Calandra NA, Erickson GA, Li L, Liu L, Nilson MG, Strambeanu II, VanGelder KF, Woodard JL, Xie S, Allen CL, Kowalski JA, Leitch DC. Convergent Synthesis of the NS5B Inhibitor GSK8175 Enabled by Transition Metal Catalysis. The Journal of Organic Chemistry. PMID 30339385 DOI: 10.1021/Acs.Joc.8B02269  0.492
2018 Vantourout JC, Li L, Bendito-Moll E, Chabbra S, Arrington K, Bode BE, Isidro-Llobet A, Kowalski JA, Nilson MG, Wheelhouse KMP, Woodard JL, Xie S, Leitch DC, Watson AJB. Mechanistic Insight Enables Practical, Scalable, Room Temperature Chan–Lam N-Arylation of N-Aryl Sulfonamides Acs Catalysis. 8: 9560-9566. DOI: 10.1021/Acscatal.8B03238  0.357
2018 Dunn AL, Leitch DC, Journet M, Martin M, Tabet EA, Curtis NR, Williams G, Goss C, Shaw T, O’Hare B, Wade C, Toczko MA, Liu P. Selective Continuous Flow Iodination Guided by Direct Spectroscopic Observation of Equilibrating Aryl Lithium Regioisomers Organometallics. 38: 129-137. DOI: 10.1021/Acs.Organomet.8B00538  0.323
2018 Kaplan JM, Hruszkewycz DP, Strambeanu II, Nunn CJ, VanGelder KF, Dunn AL, Wozniak DI, Dobereiner GE, Leitch DC. Scalable and Chemoselective Synthesis of γ-Keto Esters and Acids via Pd-Catalyzed Carbonylation of Cyclic β-Chloro Enones Organometallics. 38: 85-96. DOI: 10.1021/Acs.Organomet.8B00468  0.411
2018 Lim JJ, Leitch DC. Lewis Acid-Catalyzed Addition of Benzophenone Imine to Epoxides Enables the Selective Synthesis and Derivatization of Primary 1,2-Amino Alcohols Organic Process Research & Development. 22: 641-649. DOI: 10.1021/Acs.Oprd.8B00133  0.409
2017 Leitch DC, John MP, Slavin PA, Searle AD. An Evaluation of Multiple Catalytic Systems for the Cyanation of 2,3-Dichlorobenzoyl Chloride: Application to the Synthesis of Lamotrigine Organic Process Research & Development. 21: 1815-1821. DOI: 10.1021/Acs.Oprd.7B00262  0.464
2017 Leitch DC, Greene TF, O’Keeffe R, Lovelace TC, Powers JD, Searle AD. A Combined High-Throughput Screening and Reaction Profiling Approach toward Development of a Tandem Catalytic Hydrogenation for the Synthesis of Salbutamol Organic Process Research & Development. 21: 1806-1814. DOI: 10.1021/Acs.Oprd.7B00261  0.441
2016 Erguven H, Leitch DC, Keyzer EN, Arndtsen BA. Development and Cycloaddition Reactivity of a New Class of Pyridine-Based Mesoionic 1,3-Dipole. Angewandte Chemie (International Ed. in English). PMID 28004875 DOI: 10.1002/Anie.201609726  0.661
2015 Leitch DC, Kayser LV, Han ZY, Siamaki AR, Keyzer EN, Gefen A, Arndtsen BA. A palladium-catalysed multicomponent coupling approach to conjugated poly(1,3-dipoles) and polyheterocycles. Nature Communications. 6: 7411. PMID 26077769 DOI: 10.1038/Ncomms8411  0.738
2015 Horrillo-Martinez P, Leitch DC, Ryken SA, Thomson RK, Beard JD, Patrick BO, Schafer LL, Giesbrecht GR. Titanium amidate complexes as active catalysts for the synthesis of high molecular weight polyethylene Canadian Journal of Chemistry. 93: 775-783. DOI: 10.1139/Cjc-2015-0081  0.781
2015 Labinger JA, Leitch DC, Bercaw JE, Deimund MA, Davis ME. Upgrading Light Hydrocarbons: A Tandem Catalytic System for Alkane/Alkene Coupling Topics in Catalysis. 58: 494-501. DOI: 10.1007/S11244-015-0380-2  0.701
2014 Yim JC, Bexrud JA, Ayinla RO, Leitch DC, Schafer LL. Bis(amidate)bis(amido) titanium complex: a regioselective intermolecular alkyne hydroamination catalyst. The Journal of Organic Chemistry. 79: 2015-28. PMID 24506303 DOI: 10.1021/Jo402668Q  0.779
2014 Leitch DC, Labinger JA, Bercaw JE. Scope and mechanism of homogeneous tantalum/iridium tandem catalytic alkane/alkene upgrading using sacrificial hydrogen acceptors Organometallics. 33: 3353-3365. DOI: 10.1021/Om500231T  0.684
2013 Leitch DC, Lam YC, Labinger JA, Bercaw JE. Upgrading light hydrocarbons via tandem catalysis: a dual homogeneous Ta/Ir system for alkane/alkene coupling. Journal of the American Chemical Society. 135: 10302-5. PMID 23799786 DOI: 10.1021/Ja405191A  0.699
2011 Leitch DC, Platel RH, Schafer LL. Mechanistic elucidation of intramolecular aminoalkene hydroamination catalyzed by a tethered bis(ureate) complex: evidence for proton-assisted C-N bond formation at zirconium. Journal of the American Chemical Society. 133: 15453-63. PMID 21851117 DOI: 10.1021/Ja202448B  0.795
2011 Payne PR, Bexrud JA, Leitch DC, Schafer LL. Asymmetric hydroamination catalyzed by in situ generated chiral amidate and ureate complexes of zirconium - Probing the role of the tether in ligand design Canadian Journal of Chemistry. 89: 1222-1229. DOI: 10.1139/V11-091  0.776
2010 Leitch DC, Turner CS, Schafer LL. Isolation of catalytic intermediates in hydroamination reactions: insertion of internal alkynes into a zirconium-amido bond. Angewandte Chemie (International Ed. in English). 49: 6382-6. PMID 20665612 DOI: 10.1002/Anie.201001927  0.636
2010 Leitch DC, Schafer LL. Zirconium alkyl complexes supported by ureate ligands: Synthesis, characterization, and precursors to metal-element multiple bonds Organometallics. 29: 5162-5172. DOI: 10.1021/Om100381D  0.699
2010 Wood MC, Leitch DC, Yeung CS, Kozak JA, Schafer LL. Corrigendum: Chiral Neutral Zirconium Amidate Complexes for the Asymmetric Hydroamination of Alkenes Angewandte Chemie. 49: 6475-6475. DOI: 10.1002/Anie.201090117  0.781
2009 Leitch DC, Payne PR, Dunbar CR, Schafer LL. Broadening the scope of group 4 hydroamination catalysis using a tethered ureate ligand. Journal of the American Chemical Society. 131: 18246-7. PMID 19994887 DOI: 10.1021/Ja906955B  0.778
2009 Bexrud JA, Eisenberger P, Leitch DC, Payne PR, Schafer LL. Selective C-H activation alpha to primary amines. Bridging metallaaziridines for catalytic, intramolecular alpha-alkylation. Journal of the American Chemical Society. 131: 2116-8. PMID 19173650 DOI: 10.1021/Ja808862W  0.741
2009 Leitch DC, Beard JD, Thomson RK, Wright VA, Patrick BO, Schafer LL. N,O-chelates of group 4 Metals: Contrasting the use of amidates and ureates in the synthesis of metal dichlorides European Journal of Inorganic Chemistry. 2009: 2691-2701. DOI: 10.1002/Ejic.200900254  0.776
2007 Zhang Z, Leitch DC, Lu M, Patrick BO, Schafer LL. An easy-to-use, regioselective, and robust bis(amidate) titanium hydroamination precatalyst: mechanistic and synthetic investigations toward the preparation of tetrahydroisoquinolines and benzoquinolizine alkaloids. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 2012-22. PMID 17131447 DOI: 10.1002/Chem.200600735  0.738
2007 Wood MC, Leitch DC, Yeung CS, Kozak JA, Schafer LL. Chiral neutral zirconium amidate complexes for the asymmetric hydroamination of alkenes. Angewandte Chemie (International Ed. in English). 46: 354-8. PMID 17029322 DOI: 10.1002/Anie.200603017  0.781
2005 Bexrud JA, Beard JD, Leitch DC, Schafer LL. Intramolecular hydroamination of unactived olefins with Ti(NMe2)4 as a precatalyst. Organic Letters. 7: 1959-62. PMID 15876029 DOI: 10.1021/Ol0503992  0.777
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