Florian Lesage - Publications

Affiliations: 
IPMC CNRS & University of Nice (France) 

97 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Khoubza L, Chatelain FC, Feliciangeli S, Lesage F, Bichet D. Physiological roles of heteromerization: focus on the two-pore domain potassium channels. The Journal of Physiology. PMID 33347640 DOI: 10.1113/JP279870  0.4
2019 Royal P, Andres-Bilbe A, Ávalos Prado P, Verkest C, Wdziekonski B, Schaub S, Baron A, Lesage F, Gasull X, Levitz J, Sandoz G. Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK. Neuron. 101: 232-245.e6. PMID 30573346 DOI: 10.1016/j.neuron.2018.11.039  0.64
2018 Soussia IB, Choveau FS, Blin S, Kim EJ, Feliciangeli S, Chatelain FC, Kang D, Bichet D, Lesage F. Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels. Frontiers in Molecular Neuroscience. 11: 301. PMID 30233308 DOI: 10.3389/fnmol.2018.00301  0.4
2017 Bobak N, Feliciangeli S, Chen CC, Ben Soussia I, Bittner S, Pagnotta S, Ruck T, Biel M, Wahl-Schott C, Grimm C, Meuth SG, Lesage F. Recombinant tandem of pore-domains in a Weakly Inward rectifying K(+) channel 2 (TWIK2) forms active lysosomal channels. Scientific Reports. 7: 649. PMID 28381826 DOI: 10.1038/s41598-017-00640-8  0.4
2016 Christensen AH, Chatelain FC, Huttner IG, Olesen MS, Soka M, Feliciangeli S, Horvat C, Santiago CF, Vandenberg JI, Schmitt N, Olesen SP, Lesage F, Fatkin D. The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size. Journal of Molecular and Cellular Cardiology. PMID 27103460 DOI: 10.1016/j.yjmcc.2016.04.006  0.64
2016 Ronjat M, Feng W, Dardevet L, Dong Y, Al Khoury S, Chatelain FC, Vialla V, Chahboun S, Lesage F, Darbon H, Pessah IN, De Waard M. In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071086 DOI: 10.1073/pnas.1517342113  0.64
2016 Blin S, Ben Soussia I, Kim EJ, Brau F, Kang D, Lesage F, Bichet D. Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties. Proceedings of the National Academy of Sciences of the United States of America. PMID 27035965 DOI: 10.1073/pnas.1522748113  0.64
2015 Feliciangeli S, Chatelain FC, Bichet D, Lesage F. The family of K2P channels: salient structural and functional properties. The Journal of Physiology. 593: 2587-603. PMID 25530075 DOI: 10.1113/jphysiol.2014.287268  0.4
2015 Bichet D, Blin S, Feliciangeli S, Chatelain FC, Bobak N, Lesage F. Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2. Pflugers Archiv : European Journal of Physiology. 467: 1121-31. PMID 25339226 DOI: 10.1007/s00424-014-1631-y  0.4
2014 Pereira V, Busserolles J, Christin M, Devilliers M, Poupon L, Legha W, Alloui A, Aissouni Y, Bourinet E, Lesage F, Eschalier A, Lazdunski M, Noël J. Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception. Pain. 155: 2534-44. PMID 25239074 DOI: 10.1016/j.pain.2014.09.013  0.64
2014 Comoglio Y, Levitz J, Kienzler MA, Lesage F, Isacoff EY, Sandoz G. Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid. Proceedings of the National Academy of Sciences of the United States of America. 111: 13547-52. PMID 25197053 DOI: 10.1073/pnas.1407160111  0.64
2014 Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D. Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels. The Journal of Biological Chemistry. 289: 28202-12. PMID 25148687 DOI: 10.1074/jbc.M114.600437  0.4
2014 Xiao Z, Cilz NI, Kurada L, Hu B, Yang C, Wada E, Combs CK, Porter JE, Lesage F, Lei S. Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 7027-42. PMID 24828655 DOI: 10.1523/JNEUROSCI.0408-14.2014  0.64
2014 Rodrigues N, Bennis K, Vivier D, Pereira V, Chatelain FC, Chapuy E, Deokar H, Busserolles J, Lesage F, Eschalier A, Ducki S. Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel European Journal of Medicinal Chemistry. 75: 391-402. PMID 24561669 DOI: 10.1016/j.ejmech.2014.01.049  0.64
2013 Wang W, Putra A, Schools GP, Ma B, Chen H, Kaczmarek LK, Barhanin J, Lesage F, Zhou M. The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments. Frontiers in Cellular Neuroscience. 7: 246. PMID 24368895 DOI: 10.3389/fncel.2013.00246  0.48
2013 Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F. Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane. The Journal of Biological Chemistry. 288: 35081-92. PMID 24163367 DOI: 10.1074/jbc.M113.503318  0.4
2013 Wang S, Benamer N, Zanella S, Kumar NN, Shi Y, Bévengut M, Penton D, Guyenet PG, Lesage F, Gestreau C, Barhanin J, Bayliss DA. TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16033-44. PMID 24107938 DOI: 10.1523/JNEUROSCI.2451-13.2013  0.64
2013 Chatelain FC, Mazzuca M, Larroque MM, Rogemond V, Honnorat J, Lesage F. An ion channel chip for diagnosis and prognosis of autoimmune neurological disorders. Recent Patents On Cns Drug Discovery. 8: 171-9. PMID 24050250  0.56
2013 Bandulik S, Tauber P, Penton D, Schweda F, Tegtmeier I, Sterner C, Lalli E, Lesage F, Hartmann M, Barhanin J, Warth R. Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system. Endocrinology. 154: 2712-22. PMID 23698720 DOI: 10.1210/en.2013-1101  0.48
2012 Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, et al. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. The Embo Journal. 31: 3730-44. PMID 22892567 DOI: 10.1038/emboj.2012.226  0.64
2012 Penton D, Bandulik S, Schweda F, Haubs S, Tauber P, Reichold M, Cong LD, El Wakil A, Budde T, Lesage F, Lalli E, Zennaro MC, Warth R, Barhanin J. Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension. Endocrinology. 153: 4740-8. PMID 22878402 DOI: 10.1210/en.2012-1527  0.64
2012 Peyronnet R, Sharif-Naeini R, Folgering JH, Arhatte M, Jodar M, El Boustany C, Gallian C, Tauc M, Duranton C, Rubera I, Lesage F, Pei Y, Peters DJ, Somlo S, Sachs F, et al. Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels. Cell Reports. 1: 241-50. PMID 22832196 DOI: 10.1016/j.celrep.2012.01.006  0.64
2012 Chatelain FC, Bichet D, Douguet D, Feliciangeli S, Bendahhou S, Reichold M, Warth R, Barhanin J, Lesage F. TWIK1, a unique background channel with variable ion selectivity Proceedings of the National Academy of Sciences of the United States of America. 109: 5499-5504. PMID 22431633 DOI: 10.1073/pnas.1201132109  0.64
2011 Lesage F, Barhanin J. Molecular physiology of pH-sensitive background K(2P) channels. Physiology (Bethesda, Md.). 26: 424-37. PMID 22170960 DOI: 10.1152/physiol.00029.2011  0.48
2011 Noël J, Sandoz G, Lesage F. Molecular regulations governing TREK and TRAAK channel functions. Channels (Austin, Tex.). 5: 402-9. PMID 21829087 DOI: 10.4161/chan.5.5.16469  0.64
2010 Gestreau C, Heitzmann D, Thomas J, Dubreuil V, Bandulik S, Reichold M, Bendahhou S, Pierson P, Sterner C, Peyronnet-Roux J, Benfriha C, Tegtmeier I, Ehnes H, Georgieff M, Lesage F, et al. Task2 potassium channels set central respiratory CO2 and O2 sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 107: 2325-30. PMID 20133877 DOI: 10.1073/pnas.0910059107  0.64
2010 Feliciangeli S, Tardy MP, Sandoz G, Chatelain FC, Warth R, Barhanin J, Bendahhou S, Lesage F. Potassium channel silencing by constitutive endocytosis and intracellular sequestration Journal of Biological Chemistry. 285: 4798-4805. PMID 19959478 DOI: 10.1074/jbc.M109.078535  0.64
2010 Burdakov D, Lesage F. Glucose-induced inhibition: how many ionic mechanisms? Acta Physiologica (Oxford, England). 198: 295-301. PMID 19473131 DOI: 10.1111/j.1748-1716.2009.02005.x  0.64
2009 Sandoz G, Douguet D, Chatelain F, Lazdunski M, Lesage F. Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue. Proceedings of the National Academy of Sciences of the United States of America. 106: 14628-33. PMID 19667202 DOI: 10.1073/pnas.0906267106  0.64
2009 Guyon A, Tardy MP, Rovère C, Nahon JL, Barhanin J, Lesage F. Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2528-33. PMID 19244527 DOI: 10.1523/JNEUROSCI.5764-08.2009  0.48
2008 Sandoz G, Lesage F. Protein complex analysis of native brain potassium channels by proteomics. Methods in Molecular Biology (Clifton, N.J.). 491: 113-23. PMID 18998088 DOI: 10.1007/978-1-59745-526-8_9  0.64
2008 Sandoz G, Tardy MP, Thümmler S, Feliciangeli S, Lazdunski M, Lesage F. Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 8545-52. PMID 18716213 DOI: 10.1523/JNEUROSCI.1962-08.2008  0.64
2008 Heitzmann D, Derand R, Jungbauer S, Bandulik S, Sterner C, Schweda F, El Wakil A, Lalli E, Guy N, Mengual R, Reichold M, Tegtmeier I, Bendahhou S, Gomez-Sanchez CE, Aller MI, ... ... Lesage F, et al. Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis. The Embo Journal. 27: 179-87. PMID 18034154 DOI: 10.1038/sj.emboj.7601934  0.64
2007 Feliciangeli S, Bendahhou S, Sandoz G, Gounon P, Reichold M, Warth R, Lazdunski M, Barhanin J, Lesage F. Does Sumoylation Control K2P1/TWIK1 Background K+ Channels? Cell. 130: 563-569. PMID 17693262 DOI: 10.1016/j.cell.2007.06.012  0.64
2006 Sandoz G, Thümmler S, Duprat F, Feliciangeli S, Vinh J, Escoubas P, Guy N, Lazdunski M, Lesage F. AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K+ channels into open leak channels Embo Journal. 25: 5864-5872. PMID 17110924 DOI: 10.1038/sj.emboj.7601437  0.64
2006 Zanzouri M, Lauritzen I, Duprat F, Mazzuca M, Lesage F, Lazdunski M, Patel A. Membrane potential-regulated transcription of the resting K+ conductance TASK-3 via the calcineurin pathway. The Journal of Biological Chemistry. 281: 28910-8. PMID 16864570 DOI: 10.1074/jbc.M606092200  0.56
2005 Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. Pharmacological Reviews. 57: 527-40. PMID 16382106 DOI: 10.1124/pr.57.4.12  0.64
2005 Ebensperger G, Ebensperger R, Herrera EA, Riquelme RA, Sanhueza EM, Lesage F, Marengo JJ, Tejo RI, Llanos AJ, Reyes RV. Fetal brain hypometabolism during prolonged hypoxaemia in the llama. The Journal of Physiology. 567: 963-75. PMID 16037083 DOI: 10.1113/jphysiol.2005.094524  0.64
2004 Decressac S, Franco M, Bendahhou S, Warth R, Knauer S, Barhanin J, Lazdunski M, Lesage F. ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor foe ARF6 Embo Reports. 5: 1171-1175. PMID 15540117 DOI: 10.1038/sj.embor.7400292  0.64
2004 Nicolas MT, Lesage F, Reyes R, Barhanin J, Demêmes D. Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat. Brain Research. 1017: 46-52. PMID 15261098 DOI: 10.1016/j.brainres.2004.05.012  0.48
2004 Warth R, Barrière H, Meneton P, Bloch M, Thomas J, Tauc M, Heitzmann D, Romeo E, Verrey F, Mengual R, Guy N, Bendahhou S, Lesage F, Poujeol P, Barhanin J. Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport Proceedings of the National Academy of Sciences of the United States of America. 101: 8215-8220. PMID 15141089 DOI: 10.1073/pnas.0400081101  0.64
2004 Lesage F, Hibino H, Hudspeth AJ. Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 101: 671-5. PMID 14701909 DOI: 10.1073/pnas.0307681100  0.64
2003 Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, ... ... Lesage F, et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacological Reviews. 55: 583-6. PMID 14657415 DOI: 10.1124/pr.55.4.9  0.64
2003 Chemin J, Girard C, Duprat F, Lesage F, Romey G, Lazdunski M. Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels. The Embo Journal. 22: 5403-11. PMID 14532113 DOI: 10.1093/emboj/cdg528  0.56
2003 Barriere H, Belfodil R, Rubera I, Tauc M, Lesage F, Poujeol C, Guy N, Barhanin J, Poujeol P. Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules Journal of General Physiology. 122: 177-190. PMID 12860925 DOI: 10.1085/jgp.200308820  0.64
2002 Hibino H, Pironkova R, Onwumere O, Vologodskaia M, Hudspeth AJ, Lesage F. RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels. Neuron. 34: 411-23. PMID 11988172 DOI: 10.1016/S0896-6273(02)00667-0  0.64
2001 Terrenoire C, Lauritzen I, Lesage F, Romey G, Lazdunski M. A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics. Circulation Research. 89: 336-42. PMID 11509450 DOI: 10.1161/HH1601.094979  0.56
2001 Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Biochemical and Biophysical Research Communications. 282: 249-56. PMID 11263999 DOI: 10.1006/BBRC.2001.4562  0.36
2000 Lesage F, Lazdunski M. Molecular and functional properties of two-pore-domain potassium channels. American Journal of Physiology. Renal Physiology. 279: F793-801. PMID 11053038 DOI: 10.1152/AJPRENAL.2000.279.5.F793  0.52
2000 Lesage F, Terrenoire C, Romey G, Lazdunski M. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. The Journal of Biological Chemistry. 275: 28398-405. PMID 10880510 DOI: 10.1074/JBC.M002822200  0.6
2000 Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, Lesage F, Lazdunski M, Honoré E. TREK-1 is a heat-activated background K(+) channel. The Embo Journal. 19: 2483-91. PMID 10835347 DOI: 10.1093/emboj/19.11.2483  0.56
2000 Bearzatto B, Lesage F, Reyes R, Lazdunski M, Laduron PM. Axonal transport of TREK and TRAAK potassium channels in rat sciatic nerves. Neuroreport. 11: 927-30. PMID 10790857 DOI: 10.1097/00001756-200004070-00006  0.32
2000 Lesage F, Maingret F, Lazdunski M. Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel. Febs Letters. 471: 137-40. PMID 10767409 DOI: 10.1016/S0014-5793(00)01388-0  0.56
2000 Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E. Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK. The Journal of Biological Chemistry. 275: 10128-33. PMID 10744694 DOI: 10.1074/JBC.275.14.10128  0.56
2000 Reyes R, Lauritzen I, Lesage F, Ettaiche M, Fosset M, Lazdunski M. Immunolocalization of the arachidonic acid and mechanosensitive baseline traak potassium channel in the nervous system. Neuroscience. 95: 893-901. PMID 10670456 DOI: 10.1016/S0306-4522(99)00484-4  0.48
2000 Lesage F, Barhanin J, Meneton P. Le transport du potassium : aspects moléculaires et pathologiques. MéDecine/Sciences. 16: 663. DOI: 10.4267/10608/1709  0.44
2000 Lesage F, Patel A, Maingret F, Lauritzen I, Blondeau N, Reyes R, Heurteaux C, Romey G, Honore E, LAZDUNSKI M. 2P-DOMAIN K+ CHANNELS: STRUCTURE, PHYSIOLOGICAL FUNCTIONS, PHARMACOLOGY AND THERAPEUTIC IMPLICATIONS Biochemical Society Transactions. 28: A135-A135. DOI: 10.1042/bst028a135c  0.52
1999 Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E. Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. The Journal of Biological Chemistry. 274: 26691-6. PMID 10480871 DOI: 10.1074/jbc.274.38.26691  0.56
1999 Patel AJ, Honoré E, Lesage F, Fink M, Romey G, Lazdunski M. Inhalational anesthetics activate two-pore-domain background K+ channels. Nature Neuroscience. 2: 422-6. PMID 10321245 DOI: 10.1038/8084  0.56
1999 Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M. Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. The Journal of Biological Chemistry. 274: 11751-60. PMID 10206991 DOI: 10.1074/jbc.274.17.11751  0.32
1999 Maingret F, Fosset M, Lesage F, Lazdunski M, Honoré E. TRAAK is a mammalian neuronal mechano-gated K+ channel. The Journal of Biological Chemistry. 274: 1381-7. PMID 9880510 DOI: 10.1074/jbc.274.3.1381  0.68
1998 Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M. Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. The Journal of Biological Chemistry. 273: 30863-9. PMID 9812978 DOI: 10.1074/jbc.273.47.30863  0.36
1998 Lesage F, Lazdunski M. Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. Genomics. 51: 478-9. PMID 9721223 DOI: 10.1006/GENO.1998.5397  0.4
1998 Patel AJ, Honoré E, Maingret F, Lesage F, Fink M, Duprat F, Lazdunski M. A mammalian two pore domain mechano-gated S-like K+ channel. The Embo Journal. 17: 4283-90. PMID 9687497 DOI: 10.1093/emboj/17.15.4283  0.56
1998 Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M. A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids. The Embo Journal. 17: 3297-308. PMID 9628867 DOI: 10.1093/emboj/17.12.3297  0.6
1998 Arrighi I, Lesage F, Scimeca JC, Carle GF, Barhanin J. Structure, chromosome localization, and tissue distribution of the mouse twik K+ channel gene. Febs Letters. 425: 310-6. PMID 9559671 DOI: 10.1016/S0014-5793(98)00260-9  0.48
1997 Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M. TASK, a human background K+ channel to sense external pH variations near physiological pH. The Embo Journal. 16: 5464-71. PMID 9312005 DOI: 10.1093/emboj/16.17.5464  0.48
1997 Murer G, Adelbrecht C, Lauritzen I, Lesage F, Lazdunski M, Agid Y, Raisman-Vozari R. An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain. Neuroscience. 80: 345-57. PMID 9284339 DOI: 10.1016/S0306-4522(97)00001-8  0.56
1997 Adelbrecht C, Murer MG, Lauritzen I, Lesage F, Ladzunski M, Agid Y, Raisman-Vozari R. An immunocytochemical study of a G-protein-gated inward rectifier K+ channel (GIRK2) in the weaver mouse mesencephalon. Neuroreport. 8: 969-74. PMID 9141074 DOI: 10.1097/00001756-199703030-00030  0.64
1997 Lauritzen I, De Weille J, Adelbrecht C, Lesage F, Murer G, Raisman-Vozari R, Lazdunski M. Comparative expression of the inward rectifier K+ channel GIRK2 in the cerebellum of normal and weaver mutant mice. Brain Research. 753: 8-17. PMID 9125426 DOI: 10.1016/S0006-8993(96)01491-6  0.56
1997 Lesage F, Lauritzen I, Duprat F, Reyes R, Fink M, Heurteaux C, Lazdunski M. The structure, function and distribution of the mouse TWIK-1 K+ channel. Febs Letters. 402: 28-32. PMID 9013852 DOI: 10.1016/S0014-5793(96)01491-3  0.6
1996 Vetter DE, Mann JR, Wangemann P, Liu J, McLaughlin KJ, Lesage F, Marcus DC, Lazdunski M, Heinemann SF, Barhanin J. Inner ear defects induced by null mutation of the isk gene. Neuron. 17: 1251-64. PMID 8982171 DOI: 10.1016/S0896-6273(00)80255-X  0.64
1996 Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G. K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature. 384: 78-80. PMID 8900282 DOI: 10.1038/384078A0  0.8
1996 Fink M, Duprat F, Lesage F, Heurteaux C, Romey G, Barhanin J, Lazdunski M. A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression. The Journal of Biological Chemistry. 271: 26341-8. PMID 8824288 DOI: 10.1074/JBC.271.42.26341  0.56
1996 Lesage F, Mattéi M, Fink M, Barhanin J, Lazdunski M. Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43. Genomics. 34: 153-5. PMID 8661042 DOI: 10.1006/GENO.1996.0259  0.52
1996 Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J. A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties. The Journal of Biological Chemistry. 271: 4183-7. PMID 8626760 DOI: 10.1074/JBC.271.8.4183  0.6
1996 Lesage F, Fink M, Barhanin J, Lazdunski M, Mattéi MG. Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23. Genomics. 29: 808-9. PMID 8575783 DOI: 10.1006/GENO.1995.9928  0.4
1996 Fink M, Duprat F, Heurteaux C, Lesage F, Romey G, Barhanin J, Lazdunski M. Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N-terminal end. Febs Letters. 378: 64-8. PMID 8549804 DOI: 10.1016/0014-5793(95)01388-1  0.48
1996 Duprat F, Guillemare E, Romey G, Fink M, Lesage F, Lazdunski M, Honore E. Susceptibility of cloned K+ channels to reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America. 92: 11796-800. PMID 8524851 DOI: 10.1073/PNAS.92.25.11796  0.52
1996 Lesage F, Guillemare E, Fink M, Duprat F, Heurteaux C, Fosset M, Romey G, Barhanin J, Lazdunski M. Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels. The Journal of Biological Chemistry. 270: 28660-7. PMID 7499385 DOI: 10.1074/jbc.270.48.28660  0.56
1996 Fink M, Duprat F, Lesage F, Reyes R, Romey G, Heurteaux C, Lazdunski M. Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. The Embo Journal. 15: 6854-6862. DOI: 10.1002/j.1460-2075.1996.tb01077.x  0.72
1996 Lesage F, Reyes R, Fink M, Duprat F, Guillemare E, Lazdunski M. Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge. The Embo Journal. 15: 6400-6407. DOI: 10.1002/j.1460-2075.1996.tb01031.x  0.52
1996 Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattéi MG, Lazdunski M. Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. The Embo Journal. 15: 3322-3331. DOI: 10.1002/j.1460-2075.1996.tb00697.x  0.64
1996 Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. The Embo Journal. 15: 1004-1011. DOI: 10.1002/j.1460-2075.1996.tb00437.x  0.64
1995 Duprat F, Lesage F, Guillemare E, Fink M, Hugnot JP, Bigay J, Lazdunski M, Romey G, Barhanin J. Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers. Biochemical and Biophysical Research Communications. 212: 657-63. PMID 7626080 DOI: 10.1006/BBRC.1995.2019  0.6
1994 Honoré E, Barhanin J, Attali B, Lesage F, Lazdunski M. External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. Proceedings of the National Academy of Sciences of the United States of America. 91: 1937-41. PMID 8127910 DOI: 10.1073/PNAS.91.5.1937  0.64
1994 Lesage F, Hugnot JP, Amri EZ, Grimaldi P, Barhanin J, Lazdunski M. Expression cloning in K+ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator. Nucleic Acids Research. 22: 3685-8. PMID 7937077 DOI: 10.1093/NAR/22.18.3685  0.56
1994 Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, Hugnot JP. Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. Febs Letters. 353: 37-42. PMID 7926018 DOI: 10.1016/0014-5793(94)01007-2  0.4
1994 Honoré E, Guillemare E, Lesage F, Barhanin J, Lazdunski M. Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to functional expression in cultured myotomal muscle cells from Xenopus embryos. Febs Letters. 348: 259-62. PMID 7518400 DOI: 10.1016/0014-5793(94)00622-9  0.68
1993 Chevillard C, Attali B, Lesage F, Fontes M, Barhanin J, Lazdunski M, Mattei MG. Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization. Genomics. 15: 243-5. PMID 8432548 DOI: 10.1006/GENO.1993.1051  0.32
1993 Attali B, Guillemare E, Lesage F, Honoré E, Romey G, Lazdunski M, Barhanin J. The protein IsK is a dual activator of K+ and Cl- channels. Nature. 365: 850-2. PMID 8413671 DOI: 10.1038/365850A0  0.72
1993 Guillemare E, Honoré E, Pradier L, Lesage F, Schweitz H, Attali B, Barhanin J, Lazdunski M. Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2. Biochemistry. 31: 12463-8. PMID 1281425 DOI: 10.1021/BI00164A024  0.56
1992 Attali B, Honoré E, Lesage F, Lazdunski M, Barhanin J. Regulation of a major cloned voltage-gated K+ channel from human T lymphocytes. Febs Letters. 303: 229-32. PMID 1607023 DOI: 10.1016/0014-5793(92)80526-M  0.52
1992 Lesage F, Attali B, Lazdunski M, Barhanin J. ISK, a slowly activating voltage-sensitive K+ channel. Characterization of multiple cDNAs and gene organization in the mouse. Febs Letters. 301: 168-72. PMID 1568475 DOI: 10.1016/0014-5793(92)81240-M  0.52
1992 Honore E, Attali B, Lesage F, Barhanin J, Lazdunski M. Receptor-mediated regulation of IsK, a very slowly activating, voltage-dependent K+ channel in Xenopus oocytes. Biochemical and Biophysical Research Communications. 184: 1135-41. PMID 1375454 DOI: 10.1016/S0006-291X(05)80001-4  0.36
1992 Honoré E, Attali B, Romey G, Lesage F, Barhanin J, Lazdunski M. Different types of K+ channel current are generated by different levels of a single mRNA. The Embo Journal. 11: 2465-2471. DOI: 10.1002/j.1460-2075.1992.tb05311.x  0.6
1991 Honoré E, Attali B, Romey G, Heurteaux C, Ricard P, Lesage F, Lazdunski M, Barhanin J. Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart. The Embo Journal. 10: 2805-2811. DOI: 10.1002/j.1460-2075.1991.tb07829.x  0.52
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