Cynthia Czajkowski - Publications

Affiliations: 
University of Wisconsin, Madison, Madison, WI 
Area:
GABA(A) receptor structure-function
Website:
http://www.physiology.wisc.edu/faculty/czajkowski.html

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Ghosh B, Tsao TW, Czajkowski C. A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation. Neuropharmacology. PMID 28803966 DOI: 10.1016/j.neuropharm.2017.08.007  0.72
2014 Ding Y, Dellisanti CD, Ko MH, Czajkowski C, Puglielli L. The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides. The Journal of Biological Chemistry. 289: 32044-55. PMID 25301944 DOI: 10.1074/jbc.M114.585547  1
2013 Laha KT, Ghosh B, Czajkowski C. Macroscopic kinetics of pentameric ligand gated ion channels: comparisons between two prokaryotic channels and one eukaryotic channel. Plos One. 8: e80322. PMID 24260369 DOI: 10.1371/journal.pone.0080322  1
2013 Dellisanti CD, Ghosh B, Hanson SM, Raspanti JM, Grant VA, Diarra GM, Schuh AM, Satyshur K, Klug CS, Czajkowski C. Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. Plos Biology. 11: e1001714. PMID 24260024 DOI: 10.1371/journal.pbio.1001714  1
2013 Ghosh B, Satyshur KA, Czajkowski C. Propofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavities. The Journal of Biological Chemistry. 288: 17420-31. PMID 23640880 DOI: 10.1074/jbc.M113.464040  1
2012 Venkatachalan SP, Czajkowski C. Structural link between γ-aminobutyric acid type A (GABAA) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulation. The Journal of Biological Chemistry. 287: 6714-24. PMID 22219195 DOI: 10.1074/jbc.M111.316836  1
2011 Morlock EV, Czajkowski C. Different residues in the GABAA receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding. Molecular Pharmacology. 80: 14-22. PMID 21447642 DOI: 10.1124/mol.110.069542  1
2011 Dellisanti CD, Hanson SM, Chen L, Czajkowski C. Packing of the extracellular domain hydrophobic core has evolved to facilitate pentameric ligand-gated ion channel function. The Journal of Biological Chemistry. 286: 3658-70. PMID 21098036 DOI: 10.1074/jbc.M110.156851  1
2011 Sancar F, Czajkowski C. Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor. Neuropharmacology. 60: 520-8. PMID 21093460 DOI: 10.1016/j.neuropharm.2010.11.009  1
2011 Hanson SM, Czajkowski C. Disulphide trapping of the GABA(A) receptor reveals the importance of the coupling interface in the action of benzodiazepines. British Journal of Pharmacology. 162: 673-87. PMID 20942818 DOI: 10.1111/j.1476-5381.2010.01073.x  1
2010 Boileau AJ, Pearce RA, Czajkowski C. The short splice variant of the gamma 2 subunit acts as an external modulator of GABA(A) receptor function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4895-903. PMID 20371809 DOI: 10.1523/JNEUROSCI.5039-09.2010  1
2010 Wagoner KR, Czajkowski C. Stoichiometry of expressed alpha(4)beta(2)delta gamma-aminobutyric acid type A receptors depends on the ratio of subunit cDNA transfected. The Journal of Biological Chemistry. 285: 14187-94. PMID 20233712 DOI: 10.1074/jbc.M110.104257  1
2009 Muroi Y, Theusch CM, Czajkowski C, Jackson MB. Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA. Biophysical Journal. 96: 499-509. PMID 19167300 DOI: 10.1016/j.bpj.2008.09.037  1
2008 Hanson SM, Morlock EV, Satyshur KA, Czajkowski C. Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different. Journal of Medicinal Chemistry. 51: 7243-52. PMID 18973287 DOI: 10.1021/jm800889m  1
2008 Venkatachalan SP, Czajkowski C. A conserved salt bridge critical for GABA(A) receptor function and loop C dynamics. Proceedings of the National Academy of Sciences of the United States of America. 105: 13604-9. PMID 18757734 DOI: 10.1073/pnas.0801854105  1
2008 Sharkey LM, Czajkowski C. Individually monitoring ligand-induced changes in the structure of the GABAA receptor at benzodiazepine binding site and non-binding-site interfaces. Molecular Pharmacology. 74: 203-12. PMID 18424553 DOI: 10.1124/mol.108.044891  1
2008 Mercado J, Czajkowski C. Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions. The Journal of Biological Chemistry. 283: 15250-7. PMID 18387955 DOI: 10.1074/jbc.M708638200  1
2008 Hanson SM, Czajkowski C. Structural mechanisms underlying benzodiazepine modulation of the GABA(A) receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3490-9. PMID 18367615 DOI: 10.1523/JNEUROSCI.5727-07.2008  1
2007 Kloda JH, Czajkowski C. Agonist-, antagonist-, and benzodiazepine-induced structural changes in the alpha1 Met113-Leu132 region of the GABAA receptor. Molecular Pharmacology. 71: 483-93. PMID 17108261 DOI: 10.1124/mol.106.028662  1
2007 Sancar F, Ericksen SS, Kucken AM, Teissére JA, Czajkowski C. Structural determinants for high-affinity zolpidem binding to GABA-A receptors. Molecular Pharmacology. 71: 38-46. PMID 17012619 DOI: 10.1124/mol.106.029595  1
2007 Newell JG, Czajkowski C. Cysteine scanning mutagenesis: Mapping binding sites of ligand-gated ion channels Handbook of Neurochemistry and Molecular Neurobiology: Practical Neurochemistry Methods. 439-454. DOI: 10.1007/978-0-387-30401-4_21  1
2006 Muroi Y, Czajkowski C, Jackson MB. Local and global ligand-induced changes in the structure of the GABA(A) receptor. Biochemistry. 45: 7013-22. PMID 16752892 DOI: 10.1021/bi060222v  1
2006 Mercado J, Czajkowski C. Charged residues in the alpha1 and beta2 pre-M1 regions involved in GABAA receptor activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2031-40. PMID 16481436 DOI: 10.1523/JNEUROSCI.4555-05.2006  1
2005 Boileau AJ, Pearce RA, Czajkowski C. Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11219-30. PMID 16339017 DOI: 10.1523/JNEUROSCI.3751-05.2005  1
2005 Czajkowski C. Neurobiology: triggers for channel opening. Nature. 438: 167-8. PMID 16281019 DOI: 10.1038/438167a  1
2004 Newell JG, McDevitt RA, Czajkowski C. Mutation of glutamate 155 of the GABAA receptor beta2 subunit produces a spontaneously open channel: a trigger for channel activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 11226-35. PMID 15601928 DOI: 10.1523/JNEUROSCI.3746-04.2004  1
2004 Sancar F, Czajkowski C. A GABAA receptor mutation linked to human epilepsy (gamma2R43Q) impairs cell surface expression of alphabetagamma receptors. The Journal of Biological Chemistry. 279: 47034-9. PMID 15342642 DOI: 10.1074/jbc.M403388200  1
2004 Wagner DA, Czajkowski C, Jones MV. An arginine involved in GABA binding and unbinding but not gating of the GABA(A) receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2733-41. PMID 15028766 DOI: 10.1523/JNEUROSCI.4316-03.2004  1
2003 Boileau AJ, Li T, Benkwitz C, Czajkowski C, Pearce RA. Effects of gamma2S subunit incorporation on GABAA receptor macroscopic kinetics. Neuropharmacology. 44: 1003-12. PMID 12763093 DOI: 10.1016/S0028-3908(03)00114-X  1
2003 Newell JG, Czajkowski C. The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating. The Journal of Biological Chemistry. 278: 13166-72. PMID 12556472 DOI: 10.1074/jbc.M211905200  1
2003 Kucken AM, Teissére JA, Seffinga-Clark J, Wagner DA, Czajkowski C. Structural requirements for imidazobenzodiazepine binding to GABA(A) receptors. Molecular Pharmacology. 63: 289-96. PMID 12527800 DOI: 10.1124/mol.63.2.289  1
2002 Bowser DN, Wagner DA, Czajkowski C, Cromer BA, Parker MW, Wallace RH, Harkin LA, Mulley JC, Marini C, Berkovic SF, Williams DA, Jones MV, Petrou S. Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proceedings of the National Academy of Sciences of the United States of America. 99: 15170-5. PMID 12415111 DOI: 10.1073/pnas.212320199  1
2002 Boileau AJ, Baur R, Sharkey LM, Sigel E, Czajkowski C. The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes. Neuropharmacology. 43: 695-700. PMID 12367615 DOI: 10.1016/S0028-3908(02)00036-9  1
2002 Holden JH, Czajkowski C. Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions. The Journal of Biological Chemistry. 277: 18785-92. PMID 11896052 DOI: 10.1074/jbc.M111778200  1
2002 Boileau AJ, Newell JG, Czajkowski C. GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions. The Journal of Biological Chemistry. 277: 2931-7. PMID 11711541 DOI: 10.1074/jbc.M109334200  1
2001 Teissére JA, Czajkowski C. A (beta)-strand in the (gamma)2 subunit lines the benzodiazepine binding site of the GABA A receptor: structural rearrangements detected during channel gating. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 4977-86. PMID 11438573  1
2001 Horenstein J, Wagner DA, Czajkowski C, Akabas MH. Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment. Nature Neuroscience. 4: 477-85. PMID 11319555 DOI: 10.1038/87425  1
2001 Wagner DA, Czajkowski C. Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 67-74. PMID 11150321  1
2000 Li X, Czajkowski C, Pearce RA. Rapid and direct modulation of GABAA receptors by halothane. Anesthesiology. 92: 1366-75. PMID 10781283  1
2000 Kucken AM, Wagner DA, Ward PR, Teissére JA, Boileau AJ, Czajkowski C. Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor. Molecular Pharmacology. 57: 932-9. PMID 10779376  1
1999 Boileau AJ, Czajkowski C. Identification of transduction elements for benzodiazepine modulation of the GABA(A) receptor: three residues are required for allosteric coupling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10213-20. PMID 10575018  1
1999 Boileau AJ, Evers AR, Davis AF, Czajkowski C. Mapping the agonist binding site of the GABAA receptor: evidence for a beta-strand. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 4847-54. PMID 10366619  1
1998 Connor JX, Boileau AJ, Czajkowski C. A GABAA receptor alpha1 subunit tagged with green fluorescent protein requires a beta subunit for functional surface expression. The Journal of Biological Chemistry. 273: 28906-11. PMID 9786893 DOI: 10.1074/jbc.273.44.28906  1
1998 Boileau AJ, Kucken AM, Evers AR, Czajkowski C. Molecular dissection of benzodiazepine binding and allosteric coupling using chimeric gamma-aminobutyric acidA receptor subunits. Molecular Pharmacology. 53: 295-303. PMID 9463488  1
1997 Krasowski MD, O'Shea SM, Rick CE, Whiting PJ, Hadingham KL, Czajkowski C, Harrison NL. Alpha subunit isoform influences GABA(A) receptor modulation by propofol. Neuropharmacology. 36: 941-9. PMID 9257938 DOI: 10.1016/S0028-3908(97)00074-9  1
1996 Martin M, Czajkowski C, Karlin A. The contributions of aspartyl residues in the acetylcholine receptor gamma and delta subunits to the binding of agonists and competitive antagonists. The Journal of Biological Chemistry. 271: 13497-503. PMID 8662820 DOI: 10.1074/jbc.271.23.13497  1
1995 Czajkowski C, Karlin A. Structure of the nicotinic receptor acetylcholine-binding site. Identification of acidic residues in the delta subunit within 0.9 nm of the 5 alpha subunit-binding. The Journal of Biological Chemistry. 270: 3160-4. PMID 7852399 DOI: 10.1074/jbc.270.7.3160  1
1994 Karlin A, Akabas MH, Czajkowski C, Kaufmann C, Stauffer D, Xu M. Structures involved in binding, gating, and conduction in nicotinic acetylcholine receptors. Renal Physiology and Biochemistry. 17: 184-6. PMID 7518954 DOI: 10.1159/000173814  1
1993 Czajkowski C, Kaufmann C, Karlin A. Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine. Proceedings of the National Academy of Sciences of the United States of America. 90: 6285-9. PMID 8327511  1
1991 Czajkowski C, Karlin A. Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide. The Journal of Biological Chemistry. 266: 22603-12. PMID 1939274  1
1989 DiPaola M, Czajkowski C, Karlin A. The sidedness of the COOH terminus of the acetylcholine receptor delta subunit. The Journal of Biological Chemistry. 264: 15457-63. PMID 2768272  1
1989 Czajkowski C, DiPaola M, Bodkin M, Salazar-Jimenez G, Holtzman E, Karlin A. The intactness and orientation of acetylcholine receptor-rich membrane from Torpedo californica electric tissue. Archives of Biochemistry and Biophysics. 272: 412-20. PMID 2751309 DOI: 10.1016/0003-9861(89)90235-X  1
1989 Czajkowski C, Farb DH. Identification of an intracellular pool of gamma-aminobutyric acidA/benzodiazepine receptors en route to the cell surface of brain neurons in culture. Molecular Pharmacology. 35: 183-8. PMID 2537455  1
1989 Czajkowski C, Gibbs TT, Farb DH. Transmembrane topology of the gamma-aminobutyric acidA/benzodiazepine receptor: subcellular distribution and allosteric coupling determined in situ. Molecular Pharmacology. 35: 75-84. PMID 2536471  1
1988 Karlin A, DiPaola M, Kao P, Wang L, Czajkowski C, Chak A. Functional sites of the nicotinic acetylcholine receptor. Puerto Rico Health Sciences Journal. 7: 75. PMID 2847218  1
1986 Czajkowski C, Farb DH. Transmembrane topology and subcellular distribution of the benzodiazepine receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 6: 2857-63. PMID 3020185  1
1986 Farb DH, Czajkowski CM, Borden LA, Schiller GD, Gibbs TT. Turnover of the benzodiazepine/gamma-aminobutyric acid receptor complex determined in situ. Advances in Biochemical Psychopharmacology. 41: 51-66. PMID 3017074  1
1985 Gibbs TT, Chan CY, Czajkowski CM, Farb DH. Benzodiazepine receptor photoaffinity labeling: correlation of function with binding. European Journal of Pharmacology. 110: 171-80. PMID 2985408 DOI: 10.1016/0014-2999(85)90209-2  1
1984 Farb DH, Borden LA, Chan CY, Czajkowski CM, Gibbs TT, Schiller GD. Modulation of neuronal function through benzodiazepine receptors: biochemical and electrophysiological studies of neurons in primary monolayer cell culture. Annals of the New York Academy of Sciences. 435: 1-31. PMID 6099704  1
1984 Borden LA, Czajkowski C, Chan CY, Farb DH. Benzodiazepine receptor synthesis and degradation by neurons in culture. Science (New York, N.Y.). 226: 857-60. PMID 6093257  1
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