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Katherine S. Ryan, Ph.D. - Publications

Affiliations: 
Chemistry University of British Columbia, Vancouver, Vancouver, BC, Canada 
Website:
http://blogs.ubc.ca/ksryan/
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Daniel-Ivad P, Ryan KS. Structure of methyltransferase RedM that forms the dimethylpyrrolinium of the bisindole reductasporine. The Journal of Biological Chemistry. 105520. PMID 38042494 DOI: 10.1016/j.jbc.2023.105520  0.376
2020 Kudo Y, Awakawa T, Du YL, Jordan PA, Creamer KE, Jensen PR, Linington RG, Ryan KS, Moore BS. Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products. Acs Chemical Biology. PMID 33232109 DOI: 10.1021/acschembio.0c00824  0.514
2020 Hoffarth ER, Rothchild KW, Ryan KS. Emergence of oxygen- and pyridoxal phosphate-dependent reactions. The Febs Journal. PMID 32142210 DOI: 10.1111/Febs.15277  0.349
2019 Hedges JB, Ryan KS. Biosynthetic Pathways to Nonproteinogenic α-Amino Acids. Chemical Reviews. PMID 31869221 DOI: 10.1021/Acs.Chemrev.9B00408  0.321
2019 Wang M, Niikura H, He HY, Daniel-Ivad P, Ryan K. Biosynthesis of the nitrogen-nitrogen bond-containing L-alanosine. Angewandte Chemie (International Ed. in English). PMID 31823464 DOI: 10.1002/Anie.201913458  0.359
2019 Zhao G, Yao S, Rothchild KW, Liu T, Liu Y, Lian J, He HY, Ryan KS, Du YL. The biosynthetic gene cluster of the C-nucleoside antibiotic pyrazomycin with a rare pyrazole moiety. Chembiochem : a European Journal of Chemical Biology. PMID 31482654 DOI: 10.1002/Cbic.201900449  0.389
2019 Du YL, Higgins MA, Zhao G, Ryan KS. Convergent biosynthetic transformations to a bacterial specialized metabolite. Nature Chemical Biology. PMID 31406372 DOI: 10.1038/S41589-019-0331-5  0.454
2019 Ryan K, Hedges JB. In vitro reconstitution of the biosynthetic pathway to the nitroimidazole antibiotic azomycin. Angewandte Chemie (International Ed. in English). PMID 31231913 DOI: 10.1002/Anie.201903500  0.331
2019 Morgan KD, Andersen RJ, Ryan KS. Piperazic acid-containing natural products: structures and biosynthesis. Natural Product Reports. PMID 30949650 DOI: 10.1039/C8Np00076J  0.384
2019 He H, Henderson AC, Du YL, Ryan KS. A Two-Enzyme Pathway Links L-Arginine to Nitric Oxide in N-Nitroso Biosynthesis. Journal of the American Chemical Society. PMID 30763082 DOI: 10.1021/Jacs.8B13049  0.388
2019 Guo J, Higgins, Daniel-Ivad P, Ryan KS. An Asymmetric Reductase that Intercepts Acyclic Imino Acids ProducedIn Situby a Partner Oxidase. Journal of the American Chemical Society. 141: 12258-12267. DOI: 10.2210/Pdb6P2I/Pdb  0.338
2018 Du YL, Ryan KS. Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products. Natural Product Reports. PMID 30183796 DOI: 10.1039/C8Np00049B  0.427
2018 Ryan KS, Drennan CL. Metalloenzymes in natural product biosynthetic pathways. Natural Product Reports. PMID 30009301 DOI: 10.1039/C8Np90023J  0.58
2018 Hedges JB, Kuatsjah E, Du YL, Eltis LD, Ryan KS. Snapshots of the catalytic cycle of an O2, pyridoxal phosphate-dependent hydroxylase. Acs Chemical Biology. PMID 29466666 DOI: 10.1021/Acschembio.8B00039  0.386
2017 Du YL, He HY, Higgins MA, Ryan KS. A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate. Nature Chemical Biology. PMID 28628093 DOI: 10.1038/Nchembio.2411  0.336
2016 Alkhalaf LM, Du YL, Ryan KS. Synthetic Biology Approaches to New Bisindoles. Methods in Enzymology. 575: 21-37. PMID 27417923 DOI: 10.1016/Bs.Mie.2016.02.017  0.393
2016 Du YL, Ryan KS. Catalytic repertoire of bacterial bisindole formation. Current Opinion in Chemical Biology. 31: 74-81. PMID 26855265 DOI: 10.1016/J.Cbpa.2016.01.017  0.418
2016 Du YL, Singh R, Alkhalaf LM, Kuatsjah E, He HY, Eltis LD, Ryan KS. A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond. Nature Chemical Biology. PMID 26807714 DOI: 10.1038/Nchembio.2009  0.375
2015 Alkhalaf LM, Ryan KS. Biosynthetic manipulation of tryptophan in bacteria: pathways and mechanisms. Chemistry & Biology. 22: 317-28. PMID 25794436 DOI: 10.1016/J.Chembiol.2015.02.005  0.412
2015 Du YL, Alkhalaf LM, Ryan KS. In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly. Proceedings of the National Academy of Sciences of the United States of America. 112: 2717-22. PMID 25730866 DOI: 10.1073/Pnas.1419964112  0.429
2015 Du YL, Ryan KS. Expansion of Bisindole Biosynthetic Pathways by Combinatorial Construction. Acs Synthetic Biology. 4: 682-8. PMID 25548949 DOI: 10.1021/Sb5003218  0.432
2014 Du YL, Williams DE, Patrick BO, Andersen RJ, Ryan KS. Reconstruction of cladoniamide biosynthesis reveals nonenzymatic routes to bisindole diversity. Acs Chemical Biology. 9: 2748-54. PMID 25333917 DOI: 10.1021/Cb500728H  0.395
2014 Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore BS. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proceedings of the National Academy of Sciences of the United States of America. 111: 1957-62. PMID 24449899 DOI: 10.1073/Pnas.1319584111  0.562
2013 Sydor AM, Jost M, Ryan KS, Turo KE, Douglas CD, Drennan CL, Zamble DB. Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases. Biochemistry. 52: 1788-1801. PMID 24449932 DOI: 10.1021/Bi301600Z  0.526
2013 Du YL, Dalisay DS, Andersen RJ, Ryan KS. N-carbamoylation of 2,4-diaminobutyrate reroutes the outcome in padanamide biosynthesis. Chemistry & Biology. 20: 1002-11. PMID 23911586 DOI: 10.1016/J.Chembiol.2013.06.013  0.339
2013 Sydor AM, Jost M, Ryan KS, Turo KE, Douglas CD, Drennan CL, Zamble DB. Correction to Metal Binding Properties of Escherichia coli YjiA, a Member of the Metal Homeostasis-Associated COG0523 Family of GTPases Biochemistry. 52: 4105-4105. DOI: 10.1021/Bi4006094  0.489
2013 Du Y, Ding T, Patrick BO, Ryan KS. Xenocladoniamide F, minimal indolotryptoline from the cladoniamide pathway Tetrahedron Letters. 54: 5635-5638. DOI: 10.1016/J.Tetlet.2013.08.017  0.328
2012 Goldman PJ, Ryan KS, Hamill MJ, Howard-Jones AR, Walsh CT, Elliott SJ, Drennan CL. An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chemistry & Biology. 19: 855-65. PMID 22840773 DOI: 10.1016/J.Chembiol.2012.05.016  0.571
2012 Yamanaka K, Ryan KS, Gulder TA, Hughes CC, Moore BS. Flavoenzyme-catalyzed atropo-selective N,C-bipyrrole homocoupling in marinopyrrole biosynthesis. Journal of the American Chemical Society. 134: 12434-7. PMID 22800473 DOI: 10.1021/Ja305670F  0.672
2012 Davies J, Ryan KS. Introducing the parvome: bioactive compounds in the microbial world. Acs Chemical Biology. 7: 252-9. PMID 22074935 DOI: 10.1021/Cb200337H  0.406
2011 Ryan KS. Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold. Plos One. 6: e23694. PMID 21876764 DOI: 10.1371/Journal.Pone.0023694  0.341
2010 Roberts AA, Ryan KS, Moore BS, Gulder TA. Total (bio)synthesis: strategies of nature and of chemists. Topics in Current Chemistry. 297: 149-203. PMID 21495259 DOI: 10.1007/128_2010_79  0.695
2009 Ryan KS, Drennan CL. Divergent pathways in the biosynthesis of bisindole natural products. Chemistry & Biology. 16: 351-64. PMID 19389622 DOI: 10.1016/J.Chembiol.2009.01.017  0.612
2009 Ryan KS, Moore BS. Alkaloid biosynthesis takes root. Nature Chemical Biology. 5: 140-1. PMID 19219013 DOI: 10.1038/Nchembio0309-140  0.532
2008 Ryan KS, Chakraborty S, Howard-Jones AR, Walsh CT, Ballou DP, Drennan CL. The FAD cofactor of RebC shifts to an IN conformation upon flavin reduction. Biochemistry. 47: 13506-13. PMID 19035832 DOI: 10.1021/Bi801229W  0.556
2008 Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL. The violacein biosynthetic enzyme VioE shares a fold with lipoprotein transporter proteins. The Journal of Biological Chemistry. 283: 6467-75. PMID 18171675 DOI: 10.1074/Jbc.M708573200  0.597
2007 Ryan KS, Howard-Jones AR, Hamill MJ, Elliott SJ, Walsh CT, Drennan CL. Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC. Proceedings of the National Academy of Sciences of the United States of America. 104: 15311-6. PMID 17873060 DOI: 10.1073/Pnas.0707190104  0.611
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