| Year |
Citation |
Score |
| 2024 |
Dupré N, Gueniot F, Domenga-Denier V, Dubosclard V, Nilles C, Hill-Eubanks D, Morgenthaler-Roth C, Nelson MT, Keime C, Danglot L, Joutel A. Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL. The Journal of Clinical Investigation. PMID 38386425 DOI: 10.1172/JCI175789 |
0.499 |
|
| 2022 |
Oka F, Lee JH, Yuzawa I, Li M, von Bornstaedt D, Eikermann-Haerter K, Qin T, Chung DY, Sadeghian H, Seidel JL, Imai T, Vuralli D, Platt RF, Nelson MT, Joutel A, et al. CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis. The Journal of Clinical Investigation. PMID 35202003 DOI: 10.1172/JCI149759 |
0.355 |
|
| 2020 |
Ratelade J, Klug NR, Lombardi D, Angelim MKSC, Dabertrand F, Domenga-Denier V, Al-Shahi Salman R, Smith C, Gerbeau JF, Nelson MT, Joutel A. Reducing Hypermuscularization of the Transitional Segment between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage. Circulation. PMID 32183562 DOI: 10.1161/Circulationaha.119.040963 |
0.399 |
|
| 2019 |
Neves KB, Harvey AP, Moreton F, Montezano AC, Rios FJ, Alves-Lopes R, Nguyen Dinh Cat A, Rocchiccioli P, Delles C, Joutel A, Muir K, Touyz RM. ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. Jci Insight. PMID 31647781 DOI: 10.1172/Jci.Insight.131344 |
0.376 |
|
| 2019 |
Morris HE, Neves KB, Nilsen M, Montezano AC, Joutel A, MacLean MR, Touyz RM. Abstract P145: Notch3 Mutation is Involved in Pulmonary Vascular Dysfunction and Development of Pulmonary Arterial Hypertension Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.P145 |
0.316 |
|
| 2018 |
Ghezali L, Capone C, Baron-Menguy C, Ratelade J, Christensen S, Pedersen LØ, Domenga-Denier V, Pedersen JT, Joutel A. Notch3 immunotherapy improves cerebrovascular responses in CADASIL mice. Annals of Neurology. PMID 30014602 DOI: 10.1002/ana.25284 |
0.355 |
|
| 2018 |
Zellner A, Scharrer E, Arzberger T, Oka C, Domenga-Denier V, Joutel A, Lichtenthaler SF, Müller SA, Dichgans M, Haffner C. CADASIL brain vessels show a HTRA1 loss-of-function profile. Acta Neuropathologica. PMID 29725820 DOI: 10.1007/s00401-018-1853-8 |
0.358 |
|
| 2018 |
Frösen J, Joutel A. Smooth muscle cells of intracranial vessels: From development to disease. Cardiovascular Research. PMID 29351598 DOI: 10.1093/cvr/cvy002 |
0.303 |
|
| 2017 |
Ratelade J, Mezouar N, Domenga-Denier V, Rochey A, Plaisier E, Joutel A. Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke. The Journal of Pathology. PMID 29266233 DOI: 10.1002/Path.5023 |
0.401 |
|
| 2016 |
Baron-Menguy C, Domenga-Denier V, Ghezali L, Faraci FM, Joutel A. Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral Arteries. Hypertension (Dallas, Tex. : 1979). PMID 27821617 DOI: 10.1161/HYPERTENSIONAHA.116.08015 |
0.476 |
|
| 2015 |
Capone C, Cognat E, Ghezali L, Baron-Menguy C, Aubin D, Mesnard L, Stöhr H, Domenga-Denier V, Nelson MT, Joutel A. Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice. Annals of Neurology. PMID 26648042 DOI: 10.1002/Ana.24573 |
0.354 |
|
| 2015 |
Dabertrand F, Krøigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT. Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease. Proceedings of the National Academy of Sciences of the United States of America. 112: E796-805. PMID 25646445 DOI: 10.1073/Pnas.1420765112 |
0.411 |
|
| 2014 |
Tikka S, Baumann M, Siitonen M, Pasanen P, Pöyhönen M, Myllykangas L, Viitanen M, Fukutake T, Cognat E, Joutel A, Kalimo H. CADASIL and CARASIL. Brain Pathology (Zurich, Switzerland). 24: 525-44. PMID 25323668 DOI: 10.1111/Bpa.12181 |
0.447 |
|
| 2014 |
Cognat E, Hervé D, Joutel A. Response to letter regarding article, "Archetypal Arg169Cys mutation in NOTCH3 does not drive the pathogenesis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy via a loss-of-function mechanism". Stroke. 45: e129. PMID 24867925 DOI: 10.1161/STROKEAHA.114.005616 |
0.345 |
|
| 2014 |
Cognat E, Baron-Menguy C, Domenga-Denier V, Cleophax S, Fouillade C, Monet-Leprêtre M, Dewerchin M, Joutel A. Archetypal Arg169Cys mutation in NOTCH3 does not drive the pathogenesis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy via a loss-of-function mechanism. Stroke. 45: 842-9. PMID 24425116 DOI: 10.1161/Strokeaha.113.003339 |
0.736 |
|
| 2013 |
Monet-Leprêtre M, Haddad I, Baron-Menguy C, Fouillot-Panchal M, Riani M, Domenga-Denier V, Dussaule C, Cognat E, Vinh J, Joutel A. Abnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASIL. Brain : a Journal of Neurology. 136: 1830-45. PMID 23649698 DOI: 10.1093/brain/awt092 |
0.436 |
|
| 2013 |
Fouillade C, Baron-Menguy C, Domenga-Denier V, Thibault C, Takamiya K, Huganir R, Joutel A. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 76-86. PMID 23117660 DOI: 10.1161/Atvbaha.112.251736 |
0.76 |
|
| 2012 |
Fouillade C, Monet-Leprêtre M, Baron-Menguy C, Joutel A. Notch signalling in smooth muscle cells during development and disease. Cardiovascular Research. 95: 138-46. PMID 22266753 DOI: 10.1093/Cvr/Cvs019 |
0.744 |
|
| 2011 |
Eikermann-Haerter K, Yuzawa I, Dilekoz E, Joutel A, Moskowitz MA, Ayata C. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome mutations increase susceptibility to spreading depression. Annals of Neurology. 69: 413-8. PMID 21387384 DOI: 10.1002/Ana.22281 |
0.409 |
|
| 2011 |
Joutel A. Pathogenesis of CADASIL: transgenic and knock-out mice to probe function and dysfunction of the mutated gene, Notch3, in the cerebrovasculature. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 33: 73-80. PMID 20967782 DOI: 10.1002/bies.201000093 |
0.5 |
|
| 2010 |
Joutel A, Monet-Leprêtre M, Gosele C, Baron-Menguy C, Hammes A, Schmidt S, Lemaire-Carrette B, Domenga V, Schedl A, Lacombe P, Hubner N. Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. The Journal of Clinical Investigation. 120: 433-45. PMID 20071773 DOI: 10.1172/JCI39733 |
0.382 |
|
| 2009 |
Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG. Cadasil. The Lancet. Neurology. 8: 643-53. PMID 19539236 DOI: 10.1016/S1474-4422(09)70127-9 |
0.373 |
|
| 2009 |
Monet-Leprêtre M, Bardot B, Lemaire B, Domenga V, Godin O, Dichgans M, Tournier-Lasserve E, Cohen-Tannoudji M, Chabriat H, Joutel A. Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain. Brain : a Journal of Neurology. 132: 1601-12. PMID 19293235 DOI: 10.1093/brain/awp049 |
0.439 |
|
| 2009 |
Fouillade C, Monet Lepretre M, Carrette B, Domenga V, Joutel A. J022 Effecteurs du récepteur Notch3 dans la cellule musculaire lisse des petites artères Archives of Cardiovascular Diseases. 102: S110. DOI: 10.1016/S1875-2136(09)72397-6 |
0.633 |
|
| 2008 |
Belin De Chantemèle EJ, Retailleau K, Pinaud F, Vessières E, Bocquet A, Guihot AL, Lemaire B, Domenga V, Baufreton C, Loufrani L, Joutel A, Henrion D. Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 2216-2224. PMID 18818417 DOI: 10.1161/ATVBAHA.108.171751 |
0.398 |
|
| 2008 |
Fouillade C, Chabriat H, Riant F, Mine M, Arnoud M, Magy L, Bousser MG, Tournier-Lasserve E, Joutel A. Activating NOTCH3 mutation in a patient with small-vessel-disease of the brain. Human Mutation. 29: 452. PMID 18273901 DOI: 10.1002/Humu.9527 |
0.745 |
|
| 2007 |
Monet M, Domenga V, Lemaire B, Souilhol C, Langa F, Babinet C, Gridley T, Tournier-Lasserve E, Cohen-Tannoudji M, Joutel A. The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo. Human Molecular Genetics. 16: 982-92. PMID 17331978 DOI: 10.1093/Hmg/Ddm042 |
0.743 |
|
| 2006 |
Ishida C, Sakajiri K, Yoshita M, Joutel A, Cave-Riant F, Yamada M. CADASIL with a novel mutation in exon 7 of NOTCH3 (C388Y). Internal Medicine (Tokyo, Japan). 45: 981-5. PMID 16974063 DOI: JST.JSTAGE/internalmedicine/45.1692 |
0.35 |
|
| 2006 |
Souilhol C, Cormier S, Monet M, Vandormael-Pournin S, Joutel A, Babinet C, Cohen-Tannoudji M. NAS transgenic mouse line allows visualization of notch pathway activity in vivo Genesis. 44: 277-286. PMID 16708386 DOI: 10.1002/Dvg.20208 |
0.686 |
|
| 2005 |
Lacombe P, Oligo C, Domenga V, Tournier-Lasserve E, Joutel A. Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy. Stroke. 36: 1053-8. PMID 15817893 DOI: 10.1161/01.STR.0000163080.82766.eb |
0.384 |
|
| 2005 |
Dubroca C, Lacombe P, Domenga V, Maciazek J, Levy B, Tournier-Lasserve E, Joutel A, Henrion D. Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy. Stroke. 36: 113-7. PMID 15569862 DOI: 10.1161/01.Str.0000149949.92854.45 |
0.42 |
|
| 2004 |
Domenga V, Fardoux P, Lacombe P, Monet M, Maciazek J, Krebs LT, Klonjkowski B, Berrou E, Mericskay M, Li Z, Tournier-Lasserve E, Gridley T, Joutel A. Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes & Development. 18: 2730-5. PMID 15545631 DOI: 10.1101/Gad.308904 |
0.704 |
|
| 2004 |
Joutel A, Monet M, Domenga V, Riant F, Tournier-Lasserve E. Pathogenic mutations associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy differently affect Jagged1 binding and Notch3 activity via the RBP/JK signaling Pathway. American Journal of Human Genetics. 74: 338-47. PMID 14714274 DOI: 10.1086/381506 |
0.73 |
|
| 2003 |
Krebs LT, Xue Y, Norton CR, Sundberg JP, Beatus P, Lendahl U, Joutel A, Gridley T. Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis (New York, N.Y. : 2000). 37: 139-43. PMID 14595837 DOI: 10.1002/Gene.10241 |
0.418 |
|
| 2003 |
Ruchoux MM, Domenga V, Brulin P, Maciazek J, Limol S, Tournier-Lasserve E, Joutel A. Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. The American Journal of Pathology. 162: 329-42. PMID 12507916 DOI: 10.1016/S0002-9440(10)63824-2 |
0.484 |
|
| 2002 |
Cavé-Riant F, Denier C, Labauge P, Cécillon M, Maciazek J, Joutel A, Laberg-le Couteulx S, Tournier-Lasserve E, Barbieux-Vaquez D, Canaple S, Le Gars D, de Bray JM, Fournier H, Guy G, Penisson-Besnier I, et al. Spectrum and expression analysis of KRIT1 mutations in 121 consecutive and unrelated patients with Cerebral Cavernous Malformations European Journal of Human Genetics. 10: 733-740. PMID 12404106 DOI: 10.1038/sj.ejhg.5200870 |
0.34 |
|
| 2000 |
Joutel A, Andreux F, Gaulis S, Domenga V, Cecillon M, Battail N, Piga N, Chapon F, Godfrain C, Tournier-Lasserve E. The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. The Journal of Clinical Investigation. 105: 597-605. PMID 10712431 DOI: 10.1172/JCI8047 |
0.451 |
|
| 2000 |
Joutel A, Francois A, Gaulis S, Chapon F, Godfrain C, Tournier-Lasserve E. Vascular smooth muscle cell is the primary target of events leading from notch3 mutations to cadasil Neurobiology of Aging. 21: 8. DOI: 10.1016/S0197-4580(00)82709-8 |
0.353 |
|
| 1999 |
Joutel A, Tournier-Lasserve E. Notch signalling pathway and human diseases. Seminars in Cell & Developmental Biology. 9: 619-25. PMID 10075489 DOI: 10.1006/SCDB.1998.0261 |
0.342 |
|
| 1998 |
Furby A, Vahedi K, Force M, Larrouy S, Ruchoux MM, Joutel A, Tournier-Lasserve E. Differential diagnosis of a vascular leukoencephalopathy within a CADASIL family: use of skin biopsy electron microscopy study and direct genotypic screening. Journal of Neurology. 245: 734-40. PMID 9808243 DOI: 10.1007/s004150050277 |
0.319 |
|
| 1997 |
Joutel A, Vahedi K, Corpechot C, Troesch A, Chabriat H, Vayssière C, Cruaud C, Maciazek J, Weissenbach J, Bousser MG, Bach JF, Tournier-Lasserve E. Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients. Lancet (London, England). 350: 1511-5. PMID 9388399 DOI: 10.1016/S0140-6736(97)08083-5 |
0.306 |
|
| 1997 |
Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P, Alamowitch S, Domenga V, Cécillion M, Maréchal E, Maciazek J, Vayssière C, Cruaud C, Cabanis EA, Ruchoux MM, et al. Notch3 mutations in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a mendelian condition causing stroke and vascular dementia. Annals of the New York Academy of Sciences. 826: 213-7. PMID 9329692 DOI: 10.1111/J.1749-6632.1997.TB48472.X |
0.309 |
|
| 1996 |
Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P, Alamowitch S, Domenga V, Cécillion M, Marechal E, Maciazek J, Vayssiere C, Cruaud C, Cabanis EA, Ruchoux MM, et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature. 383: 707-10. PMID 8878478 DOI: 10.1038/383707a0 |
0.349 |
|
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