Allen M. Spiegel, M.D. - Publications

Affiliations: 
NIH - NIDDK 
Area:
endocrinology, diabetis

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Year Citation  Score
2013 Spiegel AM. G proteins--the disease spectrum expands. The New England Journal of Medicine. 368: 2515-6. PMID 23802519 DOI: 10.1056/Nejme1304751  0.323
2006 Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS. Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. Plos Genetics. 2: e51. PMID 16604156 DOI: 10.1371/Journal.Pgen.0020051  0.301
2005 Rosen JE, Costouros NG, Lorang D, Burns AL, Alexander HR, Skarulis MC, Cochran C, Pingpank JF, Marx SJ, Spiegel AM, Libutti SK. Gland size is associated with changes in gene expression profiles in sporadic parathyroid adenomas. Annals of Surgical Oncology. 12: 412-6. PMID 15915376 DOI: 10.1245/Aso.2005.03.103  0.3
2004 Spiegel AM, Weinstein LS. Inherited diseases involving g proteins and g protein-coupled receptors. Annual Review of Medicine. 55: 27-39. PMID 14746508 DOI: 10.1146/Annurev.Med.55.091902.103843  0.328
2001 Crabtree JS, Scacheri PC, Ward JM, Garrett-Beal L, Emmert-Buck MR, Edgemon KA, Lorang D, Libutti SK, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proceedings of the National Academy of Sciences of the United States of America. 98: 1118-23. PMID 11158604 DOI: 10.1073/Pnas.98.3.1118  0.303
2000 Goebel SU, Peghini PL, Goldsmith PK, Spiegel AM, Gibril F, Raffeld M, Jensen RT, Serrano J. Expression of the calcium-sensing receptor in gastrinomas. The Journal of Clinical Endocrinology and Metabolism. 85: 4131-7. PMID 11095444 DOI: 10.1210/Jcem.85.11.6963  0.319
2000 Spiegel AM. G protein defects in signal transduction. Hormone Research. 53: 17-22. PMID 10971097 DOI: 10.1159/000023526  0.346
2000 Bianco P, Riminucci M, Majolagbe A, Kuznetsov SA, Collins MT, Mankani MH, Corsi A, Bone HG, Wientroub S, Spiegel AM, Fisher LW, Robey PG. Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 15: 120-8. PMID 10646121 DOI: 10.1359/Jbmr.2000.15.1.120  0.3
2000 Goebel SU, Heppner C, Burns AL, Marx SJ, Spiegel AM, Zhuang Z, Lubensky IA, Gibril F, Jensen RT, Serrano J. Genotype/phenotype correlation of multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas. The Journal of Clinical Endocrinology and Metabolism. 85: 116-23. PMID 10634374 DOI: 10.1210/Jcem.85.1.6260  0.3
1999 Libutti SK, Alexander HR, Bartlett DL, Sampson ML, Ruddel ME, Skarulis M, Marx SJ, Spiegel AM, Simmonds W, Remaley AT. Kinetic analysis of the rapid intraoperative parathyroid hormone assay in patients during operation for hyperparathyroidism. Surgery. 126: 1145-50; discussion . PMID 10598200 DOI: 10.1067/Msy.2099.101835  0.309
1999 Marx SJ, Agarwal SK, Heppner C, Kim YS, Kester MB, Goldsmith PK, Skarulis MC, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Emmert-Buck MR, Guru SC, et al. The gene for multiple endocrine neoplasia type 1: recent findings. Bone. 25: 119-22. PMID 10423035 DOI: 10.1016/S8756-3282(99)00112-X  0.311
1999 Riminucci M, Liu B, Corsi A, Shenker A, Spiegel AM, Robey PG, Bianco P. The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gs alpha gene: site-specific patterns and recurrent histological hallmarks. The Journal of Pathology. 187: 249-58. PMID 10365102 DOI: 10.1002/(Sici)1096-9896(199901)187:2<249::Aid-Path222>3.0.Co;2-J  0.311
1999 Goldsmith PK, Fan GF, Ray K, Shiloach J, McPhie P, Rogers KV, Spiegel AM. Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor. The Journal of Biological Chemistry. 274: 11303-9. PMID 10196220 DOI: 10.1074/Jbc.274.16.11303  0.312
1999 Berger AC, Libutti SK, Bartlett DL, Skarulis MG, Marx SJ, Spiegel AM, Doppman JL, Alexander HR. Heterogeneous gland size in sporadic multiple gland parathyroid hyperplasia. Journal of the American College of Surgeons. 188: 382-9. PMID 10195722 DOI: 10.1016/S1072-7515(98)00317-2  0.363
1998 Doppman JL, Skarulis MC, Chang R, Alexander HR, Bartlett D, Libutti SK, Marx SJ, Spiegel AM. Hypocalcemic stimulation and nonselective venous sampling for localizing parathyroid adenomas: work in progress. Radiology. 208: 145-51. PMID 9646806 DOI: 10.1148/Radiology.208.1.9646806  0.339
1997 Libutti SK, Bartlett DL, jaskowiak NT, Skarulis M, Marx SJ, Spiegel AM, Fraker DL, Doppman JL, Shawker TJ, Alexander HR. The role of thyroid resection during reoperation for persistent or recurrent hyperparathyroidism. Surgery. 122: 1183-7; discussion 1. PMID 9426436 DOI: 10.1016/S0039-6060(97)90225-7  0.344
1997 Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, ... ... Spiegel AM, et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (New York, N.Y.). 276: 404-7. PMID 9103196 DOI: 10.1126/Science.276.5311.404  0.313
1997 Spiegel AM. The molecular basis of disorders caused by defects in G proteins. Hormone Research. 47: 89-96. PMID 9050946 DOI: 10.1159/000185441  0.339
1996 Doppman JL, Skarulis MC, Chen CC, Chang R, Pass HI, Fraker DL, Alexander HR, Niederle B, Marx SJ, Norton JA, Wells SA, Spiegel AM. Parathyroid adenomas in the aortopulmonary window. Radiology. 201: 456-62. PMID 8888240 DOI: 10.1148/Radiology.201.2.8888240  0.312
1996 Jaskowiak N, Norton JA, Alexander HR, Doppman JL, Shawker T, Skarulis M, Marx S, Spiegel AM, Fraker DL. A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma. Annals of Surgery. 224: 308-322. PMID 8813259 DOI: 10.1097/00000658-199609000-00007  0.333
1996 Dong Q, Brucker-Davis F, Weintraub BD, Smallridge RC, Carr FE, Battey J, Spiegel AM, Shenker A. Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes. The Journal of Clinical Endocrinology and Metabolism. 81: 1134-40. PMID 8772588 DOI: 10.1210/Jcem.81.3.8772588  0.314
1996 Spiegel AM. Mutations in G proteins and G protein-coupled receptors in endocrine disease. The Journal of Clinical Endocrinology and Metabolism. 81: 2434-42. PMID 8675557 DOI: 10.1210/Jcem.81.7.8675557  0.304
1994 Shenker A, Weinstein LS, Sweet DE, Spiegel AM. An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome. The Journal of Clinical Endocrinology and Metabolism. 79: 750-5. PMID 8077356 DOI: 10.1210/Jcem.79.3.8077356  0.318
1993 Dohlman HG, Goldsmith P, Spiegel AM, Thorner J. Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 90: 9688-92. PMID 8415763 DOI: 10.1073/Pnas.90.20.9688  0.308
1993 Shenker A, Weinstein LS, Moran A, Pescovitz OH, Charest NJ, Boney CM, Van Wyk JJ, Merino MJ, Feuillan PP, Spiegel AM. Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein GS. The Journal of Pediatrics. 123: 509-18. PMID 8410501 DOI: 10.1016/S0022-3476(05)80943-6  0.329
1993 Sugg SL, Fraker DL, Alexander R, Doppman JL, Miller DL, Chang R, Skarulis MC, Marx SJ, Spiegel AM, Norton JA. Prospective evaluation of selective venous sampling for parathyroid hormone concentration in patients undergoing reoperations for primary hyperparathyroidism. Surgery. 114: 1004-9; discussion 1. PMID 8256203 DOI: 10.5555/Uri:Pii:0039606093903155  0.329
1992 Doherty GM, Doppman JL, Miller DL, Gee MS, Marx SJ, Spiegel AM, Aurbach GD, Pass HI, Brennan MF, Norton JA. Results of a multidisciplinary strategy for management of mediastinal parathyroid adenoma as a cause of persistent primary hyperparathyroidism. Annals of Surgery. 215: 101-6. PMID 1546895 DOI: 10.1097/00000658-199202000-00002  0.553
1992 Weinstein LS, Gejman PV, de Mazancourt P, American N, Spiegel AM. A heterozygous 4-bp deletion mutation in the Gs alpha gene (GNAS1) in a patient with Albright hereditary osteodystrophy. Genomics. 13: 1319-21. PMID 1505964 DOI: 10.1016/0888-7543(92)90056-X  0.309
1992 Friedman E, De Marco L, Gejman PV, Norton JA, Bale AE, Aurbach GD, Spiegel AM, Marx SJ. Allelic loss from chromosome 11 in parathyroid tumors. Cancer Research. 52: 6804-9. PMID 1360870  0.472
1991 Fraker DL, Travis WD, Merendino JJ, Zimering MB, Streeten EA, Weinstein LS, Marx SJ, Spiegel AM, Aurbach GD, Doppman JL. Locally recurrent parathyroid neoplasms as a cause for recurrent and persistent primary hyperparathyroidism. Annals of Surgery. 213: 58-65. PMID 1985539 DOI: 10.1097/00000658-199101000-00010  0.575
1991 Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. The New England Journal of Medicine. 325: 1688-95. PMID 1944469 DOI: 10.1056/Nejm199112123252403  0.338
1991 Fargin A, Yamamoto K, Cotecchia S, Goldsmith PK, Spiegel AM, Lapetina EG, Caron MG, Lefkowitz RJ. Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. Cellular Signalling. 3: 547-57. PMID 1786205 DOI: 10.1016/0898-6568(91)90031-O  0.31
1991 Marx SJ, Menczel J, Campbell G, Aurbach GD, Spiegel AM, Norton JA. Heterogeneous size of the parathyroid glands in familial multiple endocrine neoplasia type 1. Clinical Endocrinology. 35: 521-6. PMID 1685109 DOI: 10.1111/J.1365-2265.1991.Tb00938.X  0.526
1990 Fraker DL, Doppman JL, Shawker TH, Marx SJ, Spiegel AM, Norton JA. Undescended parathyroid adenoma: an important etiology for failed operations for primary hyperparathyroidism. World Journal of Surgery. 14: 342-8. PMID 2368436 DOI: 10.1007/Bf01658522  0.346
1990 Friedman E, Bale AE, Marx SJ, Norton JA, Arnold A, Tu T, Aurbach GD, Spiegel AM. Genetic abnormalities in sporadic parathyroid adenomas. The Journal of Clinical Endocrinology and Metabolism. 71: 293-7. PMID 2199477 DOI: 10.1210/Jcem-71-2-293  0.509
1989 Spiegel AM. Receptor-effector coupling by G-proteins implications for endocrinology. Trends in Endocrinology and Metabolism: Tem. 1: 72-6. PMID 18411094 DOI: 10.1016/1043-2760(89)90006-4  0.31
1989 Friedman E, Sakaguchi K, Bale AE, Falchetti A, Streeten E, Zimering MB, Weinstein LS, McBride WO, Nakamura Y, Brandi ML, Norton JA, Aurbach GD, Spiegel AM, Marx SJ. Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1 New England Journal of Medicine. 321: 213-218. PMID 2568586 DOI: 10.1056/Nejm198907273210402  0.534
1988 Milligan G, Mullaney I, Unson CG, Marshall L, Spiegel AM, McArdle H. GTP analogues promote release of the alpha subunit of the guanine nucleotide binding protein, Gi2, from membranes of rat glioma C6 BU1 cells. The Biochemical Journal. 254: 391-6. PMID 3140801 DOI: 10.1042/Bj2540391  0.305
1988 Collu R, Bouvier C, Lagacé G, Unson CG, Milligan G, Goldsmith P, Spiegel AM. Selective deficiency of guanine nucleotide-binding protein Go in two dopamine-resistant pituitary tumors. Endocrinology. 122: 1176-8. PMID 3125040 DOI: 10.1210/Endo-122-3-1176  0.307
1988 Spiegel AM. Guanine nucleotide binding proteins and signal transduction. Vitamins and Hormones. 44: 47-101. PMID 2853488 DOI: 10.1016/S0083-6729(08)60693-7  0.303
1988 Darling GE, Marx SJ, Spiegel AM, Aurbach GD, Norton JA. Prospective analysis of intraoperative and postoperative urinary cyclic adenosine 3',5'-monophosphate levels to predict outcome of patients undergoing reoperations for primary hyperparathyroidism. Surgery. 104: 1128-36. PMID 2848325  0.499
1988 Spiegel AM. Chapter 24. G-proteins as Receptor-Effector Couplers Annual Reports in Medicinal Chemistry. 23: 235-242. DOI: 10.1016/S0065-7743(08)60852-0  0.313
1987 Miller DL, Doppman JL, Chang R, Simmons JT, O'Leary TJ, Norton JA, Spiegel AM, Marx SJ, Aurbach GD. Angiographic ablation of parathyroid adenomas: lessons from a 10-year experience. Radiology. 165: 601-7. PMID 3685340 DOI: 10.1148/Radiology.165.3.3685340  0.552
1987 Miller DL, Doppman JL, Krudy AG, Shawker TH, Norton JA, Vucich JJ, Morrish KA, Marx SJ, Spiegel AM, Aurbach GD. Localization of parathyroid adenomas in patients who have undergone surgery. Part II. Invasive procedures. Radiology. 162: 138-41. PMID 3538146 DOI: 10.1148/Radiology.162.1.3538146  0.544
1987 Miller DL, Doppman JL, Shawker TH, Krudy AG, Norton JA, Vucich JJ, Morrish KA, Marx SJ, Spiegel AM, Aurbach GD. Localization of parathyroid adenomas in patients who have undergone surgery. Part I. Noninvasive imaging methods. Radiology. 162: 133-7. PMID 3538145 DOI: 10.1148/Radiology.162.1.3538145  0.531
1987 Kern KA, Shawker TH, Doppman JL, Miller DL, Marx SJ, Spiegel AM, Aurbach GD, Norton JA. The use of high-resolution ultrasound to locate parathyroid tumors during reoperations for primary hyperparathyroidism. World Journal of Surgery. 11: 579-85. PMID 3314177 DOI: 10.1007/Bf01655831  0.559
1987 Gawler D, Milligan G, Spiegel AM, Unson CG, Houslay MD. Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes. Nature. 327: 229-32. PMID 3106832 DOI: 10.1038/327229A0  0.309
1986 Norton JA, Shawker TH, Jones BL, Spiegel AM, Marx SJ, Fitzpatrick L, Aurbach GD, Doppman JL. Intraoperative ultrasound and reoperative parathyroid surgery: an initial evaluation. World Journal of Surgery. 10: 631-9. PMID 3529650 DOI: 10.1007/Bf01655542  0.557
1986 Weinstock RS, Wright HN, Spiegel AM, Levine MA, Moses AM. Olfactory dysfunction in humans with deficient guanine nucleotide-binding protein. Nature. 322: 635-6. PMID 3018580 DOI: 10.1038/322635A0  0.341
1986 Levine MA, Jap TS, Mauseth RS, Downs RW, Spiegel AM. Activity of the stimulatory guanine nucleotide-binding protein is reduced in erythrocytes from patients with pseudohypoparathyroidism and pseudopseudohypoparathyroidism: biochemical, endocrine, and genetic analysis of Albright's hereditary osteodystrophy in six kindreds. The Journal of Clinical Endocrinology and Metabolism. 62: 497-502. PMID 3003142 DOI: 10.1210/Jcem-62-3-497  0.337
1986 Brandi ML, Aurbach GD, Fitzpatrick LA, Quarto R, Spiegel AM, Bliziotes MM, Norton JA, Doppman JL, Marx SJ. Parathyroid mitogenic activity in plasma from patients with familial multiple endocrine neoplasia type 1. The New England Journal of Medicine. 314: 1287-93. PMID 2871488 DOI: 10.1056/Nejm198605153142004  0.542
1985 Skibber JM, Reynolds JC, Spiegel AM, Marx SJ, Fitzpatrick LA, Aurbach GD, Wesley RA, Norton JA. Computerized technetium/thallium scans and parathyroid reoperation. Surgery. 98: 1077-82. PMID 3906975  0.505
1985 Doppman JL, Shawker TH, Krudy AG, Miller DL, Marx SJ, Spiegel AM, Norton JA, Brennan MF, Schaaf M, Aurbach GD. Parathymic parathyroid: CT, US, and angiographic findings. Radiology. 157: 419-23. PMID 3901107 DOI: 10.1148/Radiology.157.2.3901107  0.535
1985 Downs RW, Sekura RD, Levine MA, Spiegel AM. The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 61: 351-4. PMID 2989320 DOI: 10.1210/Jcem-61-2-351  0.336
1984 Krudy AG, Doppman JL, Marx SJ, Norton JA, Spiegel AM, Santora AC, Aurbach GD. Parathyroid aspiration directed by angiography: an alternative to venous sampling. Radiology. 152: 207-8. PMID 6729114 DOI: 10.1148/Radiology.152.1.6729114  0.522
1984 Krudy AG, Shawker TH, Doppman JL, Horvath K, Schneider PD, Norton JA, Marx SJ, Spiegel AM. Ultrasonic parathyroid localisation in previously operated patients. Clinical Radiology. 35: 113-8. PMID 6697653 DOI: 10.1016/S0009-9260(84)80007-0  0.325
1984 Krudy AG, Doppman JL, Miller DL, Norton JA, Marx SJ, Spiegel AM, Santora AC, Aurbach GD, Schaaf M. Detection of mediastinal parathyroid glands by nonselective digital arteriography. Ajr. American Journal of Roentgenology. 142: 693-5. PMID 6608224 DOI: 10.2214/Ajr.142.4.693  0.52
1984 Heinsimer JA, Davies AO, Downs RW, Levine MA, Spiegel AM, Drezner MK, De Lean A, Wreggett KA, Caron MG, Lefkowitz RJ. Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism. The Journal of Clinical Investigation. 73: 1335-43. PMID 6325502 DOI: 10.1172/Jci111336  0.306
1983 Doppman JL, Krudy AG, Marx SJ, Saxe A, Schneider P, Norton JA, Spiegel AM, Downs RW, Schaaf M, Brennan ME, Schneider AB, Aurbach GD. Aspiration of enlarged parathyroid glands for parathyroid hormone assay. Radiology. 148: 31-5. PMID 6856859 DOI: 10.1148/Radiology.148.1.6856859  0.559
1983 Levine MA, Eil C, Downs RW, Spiegel AM. Deficient guanine nucleotide regulatory unit activity in cultured fibroblast membranes from patients with pseudohypoparathyroidism type I. a cause of impaired synthesis of 3',5'-cyclic AMP by intact and broken cells. The Journal of Clinical Investigation. 72: 316-24. PMID 6308048 DOI: 10.1172/Jci110971  0.301
1983 Levine MA, Downs RW, Moses AM, Breslau NA, Marx SJ, Lasker RD, Rizzoli RE, Aurbach GD, Spiegel AM. Resistance to multiple hormones in patients with pseudohypoparathyroidism. Association with deficient activity of guanine nucleotide regulatory protein. The American Journal of Medicine. 74: 545-56. PMID 6301273 DOI: 10.1016/0002-9343(83)91008-2  0.577
1983 Krudy AG, Doppman JL, Miller DL, Marx SJ, Norton JA, Santora AC, Lasker RD, Downs RW, Spiegel AM, Aurbach GD. Work in progress: abnormal parathyroid glands. Comparison of nonselective arterial digital arteriography, selective parathyroid arteriography, and venous digital arteriography as methods of detection. Radiology. 148: 23-9. PMID 6134300 DOI: 10.1148/Radiology.148.1.6134300  0.551
1982 Krudy AG, Doppman JL, Marx SJ, Brennan MF, Spiegel A, Aurback GD. Radiographic findings in recurrent parathyroid carcinoma Radiology. 142: 625-629. PMID 7063676 DOI: 10.1148/Radiology.142.3.7063676  0.32
1982 Brennan MF, Doppman JL, Kurdy AG, Marx SJ, Spiegel AM, Aurbach GD. Assessment of techniques for preoperative parathyroid gland localization in patients undergoing reoperation for hyperparathyroidism. Surgery. 91: 6-11. PMID 7054909  0.508
1982 Marx SJ, Spiegel AM, Levine MA, Rizzoli RE, Lasker RD, Santora AC, Downs RW, Aurbach GD. Familial hypocalciuric hypercalcemia: the relation to primary parathyroid hyperplasia. The New England Journal of Medicine. 307: 416-26. PMID 7045673 DOI: 10.1056/Nejm198208123070707  0.502
1982 Spiegel AM, Levine MA, Marx SJ, Aurbach GD. Pseudohypoparathyroidism: the molecular basis for hormone resistance--a retrospective. The New England Journal of Medicine. 307: 679-81. PMID 6287258 DOI: 10.1056/Nejm198209093071111  0.507
1982 Spiegel AM, Levine MA, Aurbach GD, Downs RW, Marx SJ, Lasker RD, Moses AM, Breslau NA. Deficiency of hormone receptor-adenylate cyclase coupling protein: basis for hormone resistance in pseudohypoparathyroidism. The American Journal of Physiology. 243: E37-42. PMID 6283911 DOI: 10.1152/Ajpendo.1982.243.1.E37  0.558
1982 Krawietz W, Downs RW, Spiegel AM, Aurbach GD. Vanadate stimulates adenylate cyclase via the guanine nucleotide regulatory protein by a mechanism differing from that of fluoride. Biochemical Pharmacology. 31: 843-8. PMID 6282277 DOI: 10.1016/0006-2952(82)90472-5  0.533
1982 Stock JL, Weintraub BD, Rosen SW, Aurbach GD, Spiegel AM, Marx SJ. Human chorionic gonadotropin subunit measurement in primary hyperparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 54: 57-63. PMID 6274898 DOI: 10.1210/Jcem-54-1-57  0.583
1981 Brennan MF, Marx SJ, Doppman J, Costa J, Saxe A, Spiegel A, Krudy A, Aurbach G. Results of reoperation for persistent and recurrent hyperparathyroidism Annals of Surgery. 194: 671-676. PMID 7305478 DOI: 10.1097/00000658-198112000-00001  0.56
1981 Spiegel AM, Downs RW, Levine MA, Singer MJ, Krawietz W, Marx SJ, Woodard CJ, Reen SA, Aurbach GD. The role of guanine nucleotides in regulation of adenylate cyclase activity. Recent Progress in Hormone Research. 37: 635-65. PMID 7280358 DOI: 10.1016/B978-0-12-571137-1.50018-9  0.529
1981 Krudy AG, Doppman JL, Brennan MF, Marx SJ, Spiegel AM, Stock JL, Aurbach GD. The detection of mediastinal parathyroid glands by computed tomography, selective arteriography, and venous sampling: an analysis of 17 cases. Radiology. 140: 739-44. PMID 7280244 DOI: 10.1148/Radiology.140.3.7280244  0.528
1981 Stock JL, Krudy AG, Doppman JL, Jones AE, Brennan MF, Attie MF, Downs RW, Levine MA, Marx SJ, Spiegel AM, Aurbach GD. Parathyroid imaging after intraarterial injections of [75Se]selenomethionine. The Journal of Clinical Endocrinology and Metabolism. 52: 835-9. PMID 7228990 DOI: 10.1210/Jcem-52-5-835  0.548
1981 Spiegel AM, Marx SJ, Brennan MF, Brown EM, Downs RW, Gardner DG, Attie MF, Aurbach GD. Parathyroid function after parathyroidectomy: evaluation by measurement of urinary cAMP. Clinical Endocrinology. 15: 65-73. PMID 6273023 DOI: 10.1111/J.1365-2265.1981.Tb02749.X  0.499
1981 Downs RW, Reen SA, Levine MA, Aurbach GD, Spiegel AM. Cholera-toxin-dependent ADP-ribosylation of the adenylate cyclase regulatory protein in turkey erythrocyte membranes. Archives of Biochemistry and Biophysics. 209: 284-90. PMID 6269497 DOI: 10.1016/0003-9861(81)90282-4  0.516
1981 Krudy AG, Doppman JL, Marx SJ, Spiegel AM, Aurbach G, Brennan MF. Failure of ablation of a mediastinal parathyroid adenoma by repeated contrast staining. Radiology. 140: 63-5. PMID 6166026 DOI: 10.1148/Radiology.140.1.6166026  0.562
1981 Spiegel AM, Downs RW. Guanine nucleotides: key regulators of hormone receptor-adenylate cyclase interaction. Endocrine Reviews. 2: 275-305. PMID 6115747 DOI: 10.1210/Edrv-2-3-275  0.308
1980 Attie MF, Brown EM, Gardner DG, Spiegel AM, Aurbach GD. Characterization of the dopamine-responsive adenylate cyclase of bovine parathyroid cells and its relationship to parathyroid hormone secretion. Endocrinology. 107: 1776-81. PMID 7428692 DOI: 10.1210/Endo-107-6-1776  0.52
1980 Marx SJ, Aurbach GD, Spiegel AM. Incidence of primary hyperparathyroidism. The New England Journal of Medicine. 302: 1313. PMID 7366701  0.435
1980 Marx SJ, Spiegel AM, Brown EM, Downs RW, Attie MF, Stock JL, Levine MA, Aurbach GD. Urinary cyclic 3',5'-adenosine monophosphate (cAMP): an index of the action of parathyroid hormone on the kidney. Progress in Biochemical Pharmacology. 17: 182-9. PMID 6259655  0.477
1980 Spiegel AM, Eastman ST, Attie MF, Downs RW, Levine MA, Marx SJ, Stock JL, Saxe AW, Brennan MF, Aurbach GD. Intraoperative measurements of urinary cyclic AMP to guide surgery for primary hyperparathyroidism. The New England Journal of Medicine. 303: 1457-60. PMID 6253789 DOI: 10.1056/Nejm198012183032505  0.517
1980 Levine MA, Downs RW, Singer M, Marx SJ, Aurbach GD, Spiegel AM. Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism. Biochemical and Biophysical Research Communications. 94: 1319-24. PMID 6249307 DOI: 10.1016/0006-291X(80)90563-X  0.562
1980 Marx SJ, Spiegel AM, Sharp ME, Brown EM, Gardner DG, Downs RW, Attie MF, Stock JL. Adenosine 3',5'-monophosphate response to parathyroid hormone: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 50: 546-8. PMID 6244324 DOI: 10.1210/Jcem-50-3-546  0.316
1980 Downs RW, Spiegel AM, Singer M, Reen S, Aurbach GD. Fluoride stimulation of adenylate cyclase is dependent on the guanine nucleotide regulatory protein. The Journal of Biological Chemistry. 255: 949-54. PMID 6243302  0.473
1979 Brown EM, Gardner DG, Brennan MF, Marx SJ, Spiegel AM, Attie MF, Downs RW, Doppman JL, Aurbach CD. Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies in vitro with dispersed parathyroid cells. The American Journal of Medicine. 66: 923-31. PMID 453225 DOI: 10.1016/0002-9343(79)90446-7  0.358
1979 Doppman JL, Marx S, Spiegel A, Brown E, Downs R, Brennan MF, Aurbach G. Differential diagnosis of brown tumor vs. cystic osteitis by arteriography and computed tomography Radiology. 131: 339-340. PMID 441315 DOI: 10.1148/131.2.339  0.527
1979 Spiegel AM, Downs RW, Aurbach GD. Separation of a guanine nucleotide regulatory unit from the adenylate cyclase complex with GTP affinity chromatography. Journal of Cyclic Nucleotide Research. 5: 3-17. PMID 438399  0.476
1979 Brown EM, Broadus AE, Brennan MF, Gardner DG, Marx SJ, Spiegel AM, Downs RW, Attie M, Aurbach GD. Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 48: 604-10. PMID 429506 DOI: 10.1210/Jcem-48-4-604  0.556
1979 Brennan MF, Brown EM, Spiegel AM, Marx SJ, Doppman JL, Jones DC, Aurbach GD. Autotransplantation of cryopreserved parathyroid tissue in man. Annals of Surgery. 189: 139-42. PMID 426546 DOI: 10.1097/00000658-197902000-00002  0.559
1979 Doppman JL, Brown EM, Brennan MF, Spiegel A, Marx SJ, Aurbach GD. Angiographic ablation of parathyroid adenomas. Radiology. 130: 577-82. PMID 424518 DOI: 10.1148/130.3.577  0.539
1979 Brown EM, Brennan MF, Broadus AE, Marx SJ, Gardner DG, Spiegel AM, Downs RW, Attie MF, Aurbach GD. Human parathyroid autografts: comparison of function in vivo and in vitro. The Journal of Clinical Endocrinology and Metabolism. 48: 648-54. PMID 219003 DOI: 10.1210/Jcem-48-4-648  0.554
1978 Brown EM, Brennan MF, Hurwitz S, Windeck R, Marx SJ, Spiegel AM, Koehler JO, Gardner DG, Aurbach GD. Dispersed cells prepared from human parathyroid glands: distinct calcium sensitivity of adenomas vs. primary hyperplasia. The Journal of Clinical Endocrinology and Metabolism. 46: 267-75. PMID 750604 DOI: 10.1210/Jcem-46-2-267  0.55
1978 Brennan MF, Brown EM, Marx SJ, Spiegel AM, Broadus AE, Doppman JL, Webber B, Aurbach GD. Recurrent hyperparathyroidism from an autotransplanted parathyroid adenoma. The New England Journal of Medicine. 299: 1057-9. PMID 703772 DOI: 10.1056/Nejm197811092991909  0.543
1978 Marx SJ, Spiegel AM, Brown EM, Koehler JO, Gardner DG, Brennan MF, Aurbach GD. Divalent cation metabolism. Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. The American Journal of Medicine. 65: 235-42. PMID 686009 DOI: 10.1016/0002-9343(78)90814-8  0.499
1978 Brennan MF, Doppman JL, Marx SJ, Spiegel AM, Brown EM, Aurbach GD. Reoperative parathyroid surgery for persistent hyperparathyroidism. Surgery. 83: 669-76. PMID 644460  0.509
1978 Marx SJ, Spiegel AM, Brown EM, Windeck R, Gardner DG, Downs RW, Attie M, Aurbach GD. Circulating parathyroid hormone activity: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 47: 1190-7. PMID 233692 DOI: 10.1210/Jcem-47-6-1190  0.489
1978 Spiegel AM, Marx SJ, Brennan MF, Brown EM, Koehler JO, Aurbach GD. Urinary cAMP excretion during surgery: an index of successful parathyroidectomy in patients with primary hyperparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 47: 537-42. PMID 233674 DOI: 10.1210/Jcem-47-3-537  0.578
1978 Spiegel AM, Doppman JL, Marx SJ, Brennan MF, Brown EM, Downs RW, Gardner DG, Attie M, Aurbach GD. Preoperative localization of abnormal parathyroid: neck massage versus arteriography and selective venous sampling. Annals of Internal Medicine. 89: 935-6. PMID 214001 DOI: 10.7326/0003-4819-89-6-935  0.535
1978 Spiegel A, Greene M, Magrath I, Balow J, Marx S, Aurbach GD. Hypercalcemia with suppressed parathyroid hormone in Burkitt's lymphoma. The American Journal of Medicine. 64: 691-5. PMID 206138 DOI: 10.1016/0002-9343(78)90592-2  0.564
1977 Marx SJ, Spiegel AM, Brown EM, Aurbach GD. Family studies in patients with primary parathyroid hyperplasia. The American Journal of Medicine. 62: 698-706. PMID 871127 DOI: 10.1016/0002-9343(77)90873-7  0.568
1977 Spiegel AM, Harrison HE, Marx SJ, Brown EM, Aurbach GD. Neonatal primary hyperparathyroidism with autosomal dominant inheritance. The Journal of Pediatrics. 90: 269-72. PMID 830920 DOI: 10.1016/S0022-3476(77)80649-5  0.51
1977 Spiegel AM, Downs RW, Aurbach GD. Guanosine 5', alpha-beta-methylene, triphosphate, a novel GTP analog, causes persistent activation of adenylate cyclase: evidence against pyrophosphorylation mechanism. Biochemical and Biophysical Research Communications. 76: 758-64. PMID 197925 DOI: 10.1016/0006-291X(77)91565-0  0.514
1977 Bilezikian JP, Spiegel AM, Gammon DE, Aurbach GD. The role of guanyl nucleotides in the expression on of catecholamine-responsive adenylate cyclase during maturation of the rat reticulocyte. Molecular Pharmacology. 13: 786-95. PMID 197394  0.431
1977 Bilezikian JP, Spiegel AM, Brown EM, Aurbach GD. Identification and persistence of beta adrenergic receptors during maturation of the rat reticulocyte. Molecular Pharmacology. 13: 775-85. PMID 197393  0.433
1976 Gardner JD, Aurbach GD, Spiegel AM, Brown EM. Receptor function and ion transport in turkey erythrocytes. Recent Progress in Hormone Research. 32: 567-95. PMID 785559 DOI: 10.1016/B978-0-12-571132-6.50031-2  0.525
1976 Spiegel AM, Gerner RH, Murphy DL, Aurbach GD. Lithium does not inhibit the parathyroid hormone-mediated rise in urinary cyclic AMP and phosphate in humans. The Journal of Clinical Endocrinology and Metabolism. 43: 1390-3. PMID 187615 DOI: 10.1210/Jcem-43-6-1390  0.559
1975 Spiegel AM, Marx SJ, Doppman JL, Beazley RM, Ketcham AS, Kasten B, Aurbach GD. Intrathyroidal parathyroid adenoma or hyperplasia. An occasionally overlooked cause of surgical failure in primary hyperparathyroidism. Jama. 234: 1029-33. PMID 1242409 DOI: 10.1001/Jama.1975.03260230029018  0.552
1975 Doppman JL, Marx SJ, Spiegel AM, Mallette LE, Wolfe DR, Aurbach GD, Geelhoed G. Treatment of hyperparathyroidism by percutaneous embolization of a mediastinal adenoma. Radiology. 115: 37-42. PMID 1118615 DOI: 10.1148/115.1.37  0.548
1975 Doppman JL, Mallette LE, Marx SJ, Monchik JM, Broadus A, Spiegel AM, Beazley R, Aurbach GD. The localization of abnormal mediastinal parathyroid glands. Radiology. 115: 31-6. PMID 1118614 DOI: 10.1148/115.1.31  0.553
1974 Marx SJ, Doppman JL, Spiegel AM, Wolfe D, Aurbach GD. Embolization of a mediastinal parathyroid adenoma. The Journal of Clinical Endocrinology and Metabolism. 39: 1110-4. PMID 4372246 DOI: 10.1210/Jcem-39-6-1110  0.562
Low-probability matches (unlikely to be authored by this person)
1998 Fan GF, Ray K, Zhao XM, Goldsmith PK, Spiegel AM. Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor: effects on cell surface expression, dimerization and signal transduction. Febs Letters. 436: 353-6. PMID 9801147 DOI: 10.1016/S0014-5793(98)01165-X  0.3
2001 Guru SC, Prasad NB, Shin EJ, Hemavathy K, Lu J, Ip YT, Agarwal SK, Marx SJ, Spiegel AM, Collins FS, Oliver B, Chandrasekharappa SC. Characterization of a MEN1 ortholog from Drosophila melanogaster. Gene. 263: 31-8. PMID 11223240 DOI: 10.1016/S0378-1119(00)00562-X  0.298
1983 Spiegel AM, Saxe AW, Deftos LJ, Brennan MF. Humoral hypercalcemia caused by a rat Leydig-cell tumor is associated with suppressed parathyroid hormone secretion and increased urinary cAMP excretion. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Mã©Tabolisme. 15: 299-304. PMID 6307850 DOI: 10.1055/S-2007-1018700  0.298
1990 Weinstein LS, Gejman PV, Friedman E, Kadowaki T, Collins RM, Gershon ES, Spiegel AM. Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis. Proceedings of the National Academy of Sciences of the United States of America. 87: 8287-90. PMID 2122458 DOI: 10.1073/Pnas.87.21.8287  0.298
1990 Spiegel AM. Receptor-effector coupling by G-proteins: implications for neuronal plasticity. Progress in Brain Research. 86: 269-76. PMID 1965054 DOI: 10.1016/S0079-6123(08)63183-0  0.298
1983 Spiegel AM, Downs RW, Santora A, Marx SJ, Doppman J, Shull J. Persistent hyperparathyroidism caused by incomplete parathyroid resection and a hyperfunctioning parathyroid autograft. Jama. 250: 1896-1898. DOI: 10.1001/Jama.1983.03340140066033  0.298
2007 Wettschureck N, Lee E, Libutti SK, Offermanns S, Robey PG, Spiegel AM. Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor. Molecular Endocrinology (Baltimore, Md.). 21: 274-80. PMID 16988000 DOI: 10.1210/Me.2006-0110  0.297
1983 Spiegel AM, Marx SJ. Parathyroid hormone and vitamin D receptors. Clinics in Endocrinology and Metabolism. 12: 221-41. PMID 6303646 DOI: 10.1016/S0300-595X(83)80037-1  0.297
1983 Downs RW, Levine MA, Drezner MK, Burch WM, Spiegel AM. Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism. The Journal of Clinical Investigation. 71: 231-5. PMID 6822662 DOI: 10.1172/Jci110763  0.296
1998 Guru SC, Goldsmith PK, Burns AL, Marx SJ, Spiegel AM, Collins FS, Chandrasekharappa SC. Menin, the product of the MEN1 gene, is a nuclear protein. Proceedings of the National Academy of Sciences of the United States of America. 95: 1630-4. PMID 9465067 DOI: 10.1073/Pnas.95.4.1630  0.296
1997 Darling TN, Skarulis MC, Steinberg SM, Marx SJ, Spiegel AM, Turner M. Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1. Archives of Dermatology. 133: 853-7. PMID 9236523 DOI: 10.1001/Archderm.1997.03890430067009  0.296
1984 Krudy AG, Doppman JL, Shawker TH, Spiegel AM, Marx SJ, Norton J, Schaaf M, Moss ML, Weiss MA, Schachner SH. Hyperfunctioning cystic parathyroid glands: CT and sonographic findings. Ajr. American Journal of Roentgenology. 142: 175-8. PMID 6606954 DOI: 10.2214/Ajr.142.1.175  0.296
1997 Ray K, Fan GF, Goldsmith PK, Spiegel AM. The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction. The Journal of Biological Chemistry. 272: 31355-61. PMID 9395465 DOI: 10.1074/Jbc.272.50.31355  0.296
1993 Jones TL, Woodard C, Spiegel AM. Baculovirus expression and purification of a soluble, mutant G-protein alpha subunit. Protein Expression and Purification. 4: 64-71. PMID 8425110 DOI: 10.1006/Prep.1993.1010  0.296
1988 McKenzie FR, Kelly EC, Unson CG, Spiegel AM, Milligan G. Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates. The Biochemical Journal. 249: 653-9. PMID 2833223 DOI: 10.1042/Bj2490653  0.296
2005 Agarwal SK, Kennedy PA, Scacheri PC, Novotny EA, Hickman AB, Cerrato A, Rice TS, Moore JB, Rao S, Ji Y, Mateo C, Libutti SK, Oliver B, Chandrasekharappa SC, Burns AL, ... ... Spiegel AM, et al. Menin molecular interactions: insights into normal functions and tumorigenesis. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Mã©Tabolisme. 37: 369-74. PMID 16001329 DOI: 10.1055/S-2005-870139  0.296
1980 Marx SJ, Stock JL, Attie MF, Downs RW, Gardner DG, Brown EM, Spiegel AM, Doppman JL, Brennan MF. Familial hypocalciuric hypercalcemia: recognition among patients referred after unsuccessful parathyroid exploration. Annals of Internal Medicine. 92: 351-6. PMID 7356229 DOI: 10.7326/0003-4819-92-3-351  0.295
1987 Murphy PM, Eide B, Goldsmith P, Brann M, Gierschik P, Spiegel A, Malech HL. Detection of multiple forms of G in HL60 cells Febs Letters. 221: 81-86. PMID 3113999 DOI: 10.1016/0014-5793(87)80356-3  0.295
1980 Nielsen TB, Downs RW, Spiegel AM. Restoration of guanine nucleotide- and fluoride-stimulated activity to an adenylate cyclase-deficient cell line with affinity-purified guanine nucleotide regulatory protein. The Biochemical Journal. 190: 439-43. PMID 6258568 DOI: 10.1042/Bj1900439  0.295
1991 Bégeot M, Langlois D, Spiegel AM, Saez JM. Regulation of guanine nucleotide binding regulatory proteins in cultured adrenal cells by adrenocorticotropin and angiotensin-II. Endocrinology. 128: 3162-8. PMID 1645263 DOI: 10.1210/Endo-128-6-3162  0.295
1992 Spiegel AM. G proteins in cellular control. Current Opinion in Cell Biology. 4: 203-11. PMID 1318059 DOI: 10.1016/0960-9822(92)90519-G  0.295
1983 Attie MF, Gill JR, Stock JL, Spiegel AM, Downs RW, Levine MA, Marx SJ. Urinary calcium excretion in familial hypocalciuric hypercalcemia. Persistence of relative hypocalciuria after induction of hypoparathyroidism. The Journal of Clinical Investigation. 72: 667-76. PMID 6874959 DOI: 10.1172/Jci111016  0.295
1981 Marx SJ, Attie MF, Stock JL, Spiegel AM, Levine MA. Maximal urine-concentrating ability: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 52: 736-40. PMID 6259192 DOI: 10.1210/Jcem-52-4-736  0.294
1988 Spiegel A, Carter A, Brann M, Collins R, Goldsmith P, Simonds W, Vinitsky R, Eide B, Rossiter K, Weinstein L. Signal transduction by guanine nucleotide-binding proteins Recent Progress in Hormone Research. 44: 337-375. PMID 3146116 DOI: 10.1016/B978-0-12-571144-9.50015-6  0.294
1988 Goldsmith P, Backlund PS, Rossiter K, Carter A, Milligan G, Unson CG, Spiegel A. Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go. Biochemistry. 27: 7085-7090. PMID 3143408 DOI: 10.1021/Bi00418A062  0.293
2001 Schussheim DH, Skarulis MC, Agarwal SK, Simonds WF, Burns AL, Spiegel AM, Marx SJ. Multiple endocrine neoplasia type 1: new clinical and basic findings. Trends in Endocrinology and Metabolism: Tem. 12: 173-8. PMID 11295574 DOI: 10.1016/S1043-2760(00)00372-6  0.293
2004 Agarwal SK, Lee Burns A, Sukhodolets KE, Kennedy PA, Obungu VH, Hickman AB, Mullendore ME, Whitten I, Skarulis MC, Simonds WF, Mateo C, Crabtree JS, Scacheri PC, Ji Y, Novotny EA, ... ... Spiegel AM, et al. Molecular pathology of the MEN1 gene. Annals of the New York Academy of Sciences. 1014: 189-98. PMID 15153434 DOI: 10.1196/Annals.1294.020  0.293
1984 Gierschik P, Simons C, Woodard C, Somers R, Spiegel A. Antibodies against a retinal guanine nucleotide-binding protein cross-react with a single plasma membrane protein in non-retinal tissues Febs Letters. 172: 321-325. PMID 6204887 DOI: 10.1016/0014-5793(84)81149-7  0.293
1988 Spiegel AM. G proteins in clinical medicine. Hospital Practice (Office Ed.). 23: 93-100, 105-6, 111-2. PMID 2454242 DOI: 10.1080/21548331.1988.11703488  0.292
1987 Spiegel AM. Signal transduction by guanine nucleotide binding proteins. Molecular and Cellular Endocrinology. 49: 1-16. PMID 2435586 DOI: 10.1016/0303-7207(87)90058-X  0.292
1999 Heppner C, Reincke M, Agarwal SK, Mora P, Allolio B, Burns AL, Spiegel AM, Marx SJ. MEN1 gene analysis in sporadic adrenocortical neoplasms. The Journal of Clinical Endocrinology and Metabolism. 84: 216-9. PMID 9920087 DOI: 10.1210/Jcem.84.1.5388  0.292
2003 Sukhodolets KE, Hickman AB, Agarwal SK, Sukhodolets MV, Obungu VH, Novotny EA, Crabtree JS, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL, Marx SJ. The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. Molecular and Cellular Biology. 23: 493-509. PMID 12509449 DOI: 10.1128/Mcb.23.2.493-509.2003  0.291
2006 Cerrato A, Parisi M, Anna SS, Missirlis F, Guru S, Agarwal S, Sturgill D, Talbot T, Spiegel A, Collins F, Chandrasekharappa S, Marx S, Oliver B. Genetic interactions between Drosophila melanogaster menin and Jun/Fos Developmental Biology. 298: 59-70. PMID 16930585 DOI: 10.1016/J.Ydbio.2006.06.013  0.291
1989 Simonds WF, Goldsmith PK, Codina J, Unson CG, Spiegel AM. Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies. Proceedings of the National Academy of Sciences of the United States of America. 86: 7809-13. PMID 2510151 DOI: 10.1073/Pnas.86.20.7809  0.291
2007 Ozawa A, Agarwal SK, Mateo CM, Burns AL, Rice TS, Kennedy PA, Quigley CM, Simonds WF, Weinstein LS, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ. The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations. The Journal of Clinical Endocrinology and Metabolism. 92: 1948-51. PMID 17299066 DOI: 10.1210/Jc.2006-2563  0.291
1986 Gierschik P, Milligan G, Pines M, Goldsmith P, Codina J, Klee W, Spiegel A. Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain Proceedings of the National Academy of Sciences of the United States of America. 83: 2258-2262. PMID 3083418 DOI: 10.1073/Pnas.83.7.2258  0.291
1977 Kollarits CR, Moss ML, Cogan DG, Doppman JL, Di Chiro G, Cutler GB, Marx SJ, Spiegel AM. Scleral calcifications in hyperparathyroidism: demonstration by computed tomography. Journal of Computer Assisted Tomography. 1: 500-4. PMID 615231 DOI: 10.1097/00004728-197710000-00018  0.29
1992 Spiegel AM, Shenker A, Weinstein LS. Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction. Endocrine Reviews. 13: 536-65. PMID 1425488 DOI: 10.1210/Edrv-13-3-536  0.289
2009 Shen HC, He M, Powell A, Adem A, Lorang D, Heller C, Grover AC, Ylaya K, Hewitt SM, Marx SJ, Spiegel AM, Libutti SK. Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1. Cancer Research. 69: 1858-66. PMID 19208834 DOI: 10.1158/0008-5472.Can-08-3662  0.289
1990 Morris D, McHugh-Sutkowski E, Moos M, Simonds WF, Spiegel AM, Seamon KB. Immunoprecipitation of adenylate cyclase with an antibody to a carboxyl-terminal peptide from Gs alpha. Biochemistry. 29: 9079-84. PMID 2125472 DOI: 10.1021/Bi00490A027  0.288
1995 Chen CC, Premkumar A, Hill SC, Skarulis MC, Spiegel AM. Tc-99m sestamibi imaging of a hyperfunctioning parathyroid autograft with Doppler ultrasound and MRI correlation. Clinical Nuclear Medicine. 20: 222-5. PMID 7750215 DOI: 10.1097/00003072-199503000-00007  0.288
1998 Olufemi SE, Green JS, Manickam P, Guru SC, Agarwal SK, Kester MB, Dong Q, Burns AL, Spiegel AM, Marx SJ, Collins FS, Chandrasekharappa SC. Common ancestral mutation in the MEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland. Human Mutation. 11: 264-9. PMID 9554741 DOI: 10.1002/(Sici)1098-1004(1998)11:4<264::Aid-Humu2>3.0.Co;2-V  0.288
1990 Spiegel AM. Albright's hereditary osteodystrophy and defective G proteins. The New England Journal of Medicine. 322: 1461-2. PMID 2109829 DOI: 10.1056/Nejm199005173222010  0.288
1991 Holter W, Spiegel AM, Howard BH, Weber S, Brann MR. Expression of GTP-binding proteins and prostaglandin E2 receptors during human T cell activation. Cellular Immunology. 134: 287-95. PMID 1850662 DOI: 10.1016/0008-8749(91)90303-S  0.288
2008 Shen HC, Rosen JE, Yang LM, Savage SA, Burns AL, Mateo CM, Agarwal SK, Chandrasekharappa SC, Spiegel AM, Collins FS, Marx SJ, Libutti SK. Parathyroid tumor development involves deregulation of homeobox genes. Endocrine-Related Cancer. 15: 267-75. PMID 18310293 DOI: 10.1677/Erc-07-0191  0.287
2000 Manickam P, Vogel AM, Agarwal SK, Oda T, Spiegel AM, Marx SJ, Collins FS, Weinstein BM, Chandrasekharappa SC. Isolation, characterization, expression and functional analysis of the zebrafish ortholog of MEN1. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 11: 448-54. PMID 10818209 DOI: 10.1007/S003350010085  0.286
1996 Hermouet S, Aznavoorian S, Spiegel AM. In vitro and in vivo growth inhibition of murine melanoma K-1735 cell by a dominant negative mutant alpha subunit of the Gi2 protein. Cellular Signalling. 8: 159-66. PMID 8736698 DOI: 10.1016/0898-6568(95)02049-7  0.286
1998 Marx S, Spiegel AM, Skarulis MC, Doppman JL, Collins FS, Liotta LA. Multiple endocrine neoplasia type 1: clinical and genetic topics. Annals of Internal Medicine. 129: 484-94. PMID 9735087 DOI: 10.7326/0003-4819-129-6-199809150-00011  0.286
1997 De Luca F, Ray K, Mancilla EE, Fan GF, Winer KK, Gore P, Spiegel AM, Baron J. Sporadic hypoparathyroidism caused by de Novo gain-of-function mutations of the Ca(2+)-sensing receptor. The Journal of Clinical Endocrinology and Metabolism. 82: 2710-5. PMID 9253358 DOI: 10.1210/Jcem.82.8.4166  0.285
1976 Spiegel AM, Chiro GD, Gorden P, Ommaya AK, Kolins J, Pomeroy TC. Diagnosis of Radiosensitive Hypothalamic Tumors Without Craniotomy: Endocrine and Neuroradiologic Studies of Intracranial Atypical Teratomas Annals of Internal Medicine. 85: 290-293. PMID 786092 DOI: 10.7326/0003-4819-85-3-290  0.285
1985 Cerione RA, Codina J, Kilpatrick BF, Staniszewski C, Gierschik P, Somers RL, Spiegel AM, Birnbaumer L, Caron MG, Lefkowitz RJ. Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. Biochemistry. 24: 4499-503. PMID 3933556 DOI: 10.1021/Bi00338A002  0.285
1986 Falloon J, Malech H, Milligan G, Unson C, Kahn R, Goldsmith P, Spiegel A. Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides. Febs Letters. 209: 352-356. PMID 3466805 DOI: 10.1016/0014-5793(86)81141-3  0.285
2000 Debelenko LV, Swalwell JI, Kelley MJ, Brambilla E, Manickam P, Baibakov G, Agarwal SK, Spiegel AM, Marx SJ, Chandrasekharappa SC, Collins FS, Travis WD, Emmert-Buck MR. MEN1 gene mutation analysis of high-grade neuroendocrine lung carcinoma. Genes, Chromosomes & Cancer. 28: 58-65. PMID 10738303 DOI: 10.1002/(Sici)1098-2264(200005)28:1<58::Aid-Gcc7>3.0.Co;2-2  0.284
2002 Hu J, Mora S, Colussi G, Proverbio MC, Jones KA, Bolzoni L, De Ferrari ME, Civati G, Spiegel AM. Autosomal dominant hypocalcemia caused by a novel mutation in the loop 2 region of the human calcium receptor extracellular domain. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 17: 1461-9. PMID 12162500 DOI: 10.1359/Jbmr.2002.17.8.1461  0.284
1987 Eide B, Gierschik P, Milligan G, Mullaney I, Unson C, Goldsmith P, Spiegel AM. GTP-binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini. Biochemical and Biophysical Research Communications. 148: 1398-1405. PMID 2446610 DOI: 10.1016/S0006-291X(87)80287-5  0.283
1988 Weinstein LS, Spiegel AM, Carter AD. Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein. Febs Letters. 232: 333-40. PMID 2837412 DOI: 10.1016/0014-5793(88)80764-6  0.283
1989 Simonds WF, Goldsmith PK, Woodard CJ, Unson CG, Spiegel AM. Receptor and effector interactions of Gs. Functional studies with antibodies to the alpha s carboxyl-terminal decapeptide. Febs Letters. 249: 189-94. PMID 2500363 DOI: 10.1016/0014-5793(89)80622-2  0.282
1997 Dong Q, Debelenko LV, Chandrasekharappa SC, Emmert-Buck MR, Zhuang Z, Guru SC, Manickam P, Skarulis M, Lubensky IA, Liotta LA, Collins FS, Marx SJ, Spiegel AM. Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1. The Journal of Clinical Endocrinology and Metabolism. 82: 1416-20. PMID 9141526 DOI: 10.1210/Jcem.82.5.3944  0.281
1992 Juhnn YS, Jones TL, Spiegel AM. Amino- and carboxy-terminal deletion mutants of Gs alpha are localized to the particulate fraction of transfected COS cells. The Journal of Cell Biology. 119: 523-30. PMID 1400589 DOI: 10.1083/Jcb.119.3.523  0.281
1985 Silve C, Spiegel A. A factor produced by cultured rat Leydig tumor (Rice 500) cells associated with humoral hypercalcemia stimulates adenosine 3',5'-monophosphate production via the parathyroid hormone receptor in human skin fibroblasts. The Journal of Clinical Endocrinology and Metabolism. 60: 1144-1147. PMID 2987287 DOI: 10.1210/Jcem-60-6-1144  0.281
1985 Spiegel AM, Gierschik P, Levine MA, Downs RW. Clinical implications of guanine nucleotide-binding proteins as receptor-effector couplers. The New England Journal of Medicine. 312: 26-33. PMID 2856889 DOI: 10.1056/Nejm198501033120106  0.281
1985 Pines M, Gierschik P, Milligan G, Klee W, Spiegel A. Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain Proceedings of the National Academy of Sciences of the United States of America. 82: 4095-4099. PMID 3923487 DOI: 10.1073/Pnas.82.12.4095  0.28
2004 Hu J, Mora S, Weber G, Zamproni I, Proverbio MC, Spiegel AM. Autosomal dominant hypocalcemia in monozygotic twins caused by a de novo germline mutation near the amino-terminus of the human calcium receptor. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 19: 578-86. PMID 15005845 DOI: 10.1359/Jbmr.040106  0.28
1985 Gierschik P, Spiegel AM. Chymotrypsin selectively decreases forskolin stimulation of adenylate cyclase. Archives of Biochemistry and Biophysics. 242: 457-63. PMID 3904626 DOI: 10.1016/0003-9861(85)90230-9  0.28
1986 Heydorn WE, Gierschik P, Creed GJ, Milligan G, Spiegel A, Jacobowitz DM. The beta subunit of the guanine nucleotide regulatory proteins: identification of its location on two-dimensional gels of brain tissue and its regional and subcellular distribution in brain. Journal of Neuroscience Research. 16: 541-52. PMID 2430105 DOI: 10.1002/Jnr.490160309  0.28
1984 Spiegel AM, Rudorfer MV, Marx SJ, Linnoila M. The effect of short term lithium administration on suppressibility of parathyroid hormone secretion by calcium in vivo. The Journal of Clinical Endocrinology and Metabolism. 59: 354-7. PMID 6330156 DOI: 10.1210/Jcem-59-2-354  0.279
2001 Heppner C, Bilimoria KY, Agarwal SK, Kester M, Whitty LJ, Guru SC, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ, Burns AL. The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene. 20: 4917-25. PMID 11526476 DOI: 10.1038/Sj.Onc.1204529  0.279
1990 Weinstein LS, Kats I, Spiegel AM, Carter AD. Characterization of the promoter of the human Gi2 alpha-subunit gene. Molecular Endocrinology (Baltimore, Md.). 4: 958-64. PMID 2126599 DOI: 10.1210/Mend-4-7-958  0.279
1990 Wolfgang WJ, Quan F, Goldsmith P, Unson C, Spiegel AM, Forte M. Immunolocalization of G protein alpha-subunits in the Drosophila CNS. The Journal of Neuroscience. 10: 1014-1024. DOI: 10.1523/Jneurosci.10-03-01014.1990  0.279
1998 Collins MT, Skarulis MC, Bilezikian JP, Silverberg SJ, Spiegel AM, Marx SJ. Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent. The Journal of Clinical Endocrinology and Metabolism. 83: 1083-8. PMID 9543122 DOI: 10.1210/Jcem.83.4.4726  0.278
1996 Wenkert D, Schoneberg T, Merendino JJ, Rodriguez Pena MS, Vinitsky R, Goldsmith PK, Wess J, Spiegel AM. Functional characterization of five V2 vasopressin receptor gene mutations. Molecular and Cellular Endocrinology. 124: 43-50. PMID 9027323 DOI: 10.1016/S0303-7207(96)03926-3  0.277
1992 Hermouet S, de Mazancourt P, Spiegel AM, Farquhar MG, Wilson BS. High level expression of transfected G protein alpha i3 subunit is required for plasma membrane targeting and adenylyl cyclase inhibition in NIH 3T3 fibroblasts. Febs Letters. 312: 223-8. PMID 1330693 DOI: 10.1016/0014-5793(92)80940-I  0.277
1998 Agarwal SK, Debelenko LV, Kester MB, Guru SC, Manickam P, Olufemi SE, Skarulis MC, Heppner C, Crabtree JS, Lubensky IA, Zhuang Z, Kim YS, Chandrasekharappa SC, Collins FS, Liotta LA, ... Spiegel AM, et al. Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families. Human Mutation. 12: 75-82. PMID 9671267 DOI: 10.1002/(Sici)1098-1004(1998)12:2<75::Aid-Humu1>3.0.Co;2-T  0.277
1997 Fan G, Goldsmith PK, Collins R, Dunn CK, Krapcho KJ, Rogers KV, Spiegel AM. N-linked glycosylation of the human Ca2+ receptor is essential for its expression at the cell surface. Endocrinology. 138: 1916-22. PMID 9112387 DOI: 10.1210/Endo.138.5.5131  0.277
1982 Lasker RD, Spiegel AM. Endogenous substrates for cAMP-dependent phosphorylation in dispersed bovine parathyroid cells. Endocrinology. 111: 1412-4. PMID 6288362 DOI: 10.1210/Endo-111-4-1412  0.277
2000 Knapp JI, Heppner C, Hickman AB, Burns AL, Chandrasekharappa SC, Collins FS, Marx SJ, Spiegel AM, Agarwal SK. Identification and characterization of JunD missense mutants that lack menin binding. Oncogene. 19: 4706-12. PMID 11032020 DOI: 10.1038/Sj.Onc.1203832  0.276
1987 Gierschik P, Sidiropoulos D, Spiegel A, Jakobs KH. Purification and immunochemical characterization of the major pertussis-toxin-sensitive guanine-nucleotide-binding protein of bovine-neutrophil membranes Febs Journal. 165: 185-194. PMID 3106040 DOI: 10.1111/J.1432-1033.1987.Tb11210.X  0.276
1989 Sagi-Eisenberg R, Traub LM, Spiegel AM, Zick Y. Protein kinase C-mediated phosphorylation of retinal rod outer segment membrane proteins. Cellular Signalling. 1: 519-31. PMID 2641684 DOI: 10.1016/0898-6568(89)90036-3  0.276
1987 Carter A, Bardin C, Collins R, Simons C, Bray P, Spiegel A. Reduced expression of multiple forms of the alpha subunit of the stimulatory GTP-binding protein in pseudohypoparathyroidism type Ia. Proceedings of the National Academy of Sciences of the United States of America. 84: 7266-7269. PMID 2890163 DOI: 10.1073/Pnas.84.20.7266  0.276
1993 Degtyarev MY, Spiegel AM, Jones TL. The G protein alpha s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification. Biochemistry. 32: 8057-61. PMID 8347607 DOI: 10.1021/Bi00083A001  0.275
1993 Hermouet S, de Mazancourt P, Spiegel AM. Mitogenic effects of pertussis toxin-sensitive G-protein alpha subunits: the mitogenic action of alpha i2 in NIH 3T3 cells is mimicked by alpha i1, but not alpha i3. Cellular Signalling. 5: 215-25. PMID 8388703 DOI: 10.1016/0898-6568(93)90072-T  0.275
1997 Debelenko LV, Brambilla E, Agarwal SK, Swalwell JI, Kester MB, Lubensky IA, Zhuang Z, Guru SC, Manickam P, Olufemi SE, Chandrasekharappa SC, Crabtree JS, Kim YS, Heppner C, Burns AL, ... Spiegel AM, et al. Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Human Molecular Genetics. 6: 2285-90. PMID 9361035 DOI: 10.1093/Hmg/6.13.2285  0.275
2006 Hu J, Jiang J, Costanzi S, Thomas C, Yang W, Feyen JH, Jacobson KA, Spiegel AM. A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator. The Journal of Biological Chemistry. 281: 21558-65. PMID 16735501 DOI: 10.1074/Jbc.M603682200  0.275
2004 Scacheri PC, Crabtree JS, Kennedy AL, Swain GP, Ward JM, Marx SJ, Spiegel AM, Collins FS. Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 15: 872-7. PMID 15672591 DOI: 10.1007/S00335-004-2395-Z  0.274
2005 Hu J, McLarnon SJ, Mora S, Jiang J, Thomas C, Jacobson KA, Spiegel AM. A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+. The Journal of Biological Chemistry. 280: 5113-20. PMID 15591042 DOI: 10.1074/Jbc.M413403200  0.274
1997 Rodriguez-Pena MS, Collins R, Woodard C, Spiegel AM. Decreased insulin content and secretion in RIN 1046-38 cells overexpressing alpha 2-adrenergic receptors. Endocrine. 7: 255-60. PMID 9549052 DOI: 10.1007/Bf02778148  0.273
1994 Degtyarev MY, Spiegel AM, Jones TL. The membrane localization of the G protein alpha s subunit is not dependent on its TENIR sequence or effector domain. Cellular Signalling. 6: 25-33. PMID 8011426 DOI: 10.1016/0898-6568(94)90058-2  0.273
1982 Marx SJ, Attie MF, Spiegel AM, Levine MA, Lasker RD, Fox M. An association between neonatal severe primary hyperparathyroidism and familial hypocalciuric hypercalcemia in three kindreds. The New England Journal of Medicine. 306: 257-64. PMID 7054696 DOI: 10.1056/Nejm198202043060502  0.273
1991 Hermouet S, Merendino JJ, Gutkind JS, Spiegel AM. Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 10455-9. PMID 1660138 DOI: 10.1073/Pnas.88.23.10455  0.272
1987 Luetje CW, Gierschik P, Milligan G, Unson C, Spiegel A, Nathanson NM. Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development. Biochemistry. 26: 4876-84. PMID 3117107 DOI: 10.1021/Bi00389A040  0.272
1986 Silve C, Santora A, Breslau N, Moses A, Spiegel AM. Selective Resistance to Parathyroid Hormone in Cultured Skin Fibroblasts from Patients with Pseudohypoparathyroidism Type Ib The Journal of Clinical Endocrinology and Metabolism. 62: 640-644. PMID 3005354 DOI: 10.1210/Jcem-62-4-640  0.272
1999 Guru SC, Crabtree JS, Brown KD, Dunn KJ, Manickam P, Prasad NB, Wangsa D, Burns AL, Spiegel AM, Marx SJ, Pavan WJ, Collins FS, Chandrasekharappa SC. Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 10: 592-6. PMID 10341092 DOI: 10.1007/S003359901051  0.272
1995 Varrault A, Pena MS, Goldsmith PK, Mithal A, Brown EM, Spiegel AM. Expression of G protein alpha-subunits in bovine parathyroid. Endocrinology. 136: 4390-6. PMID 7664659 DOI: 10.1210/Endo.136.10.7664659  0.272
1997 Agarwal SK, Kester MB, Debelenko LV, Heppner C, Emmert-Buck MR, Skarulis MC, Doppman JL, Kim YS, Lubensky IA, Zhuang Z, Green JS, Guru SC, Manickam P, Olufemi SE, Liotta LA, ... ... Spiegel AM, et al. Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. Human Molecular Genetics. 6: 1169-75. PMID 9215689 DOI: 10.1093/Hmg/6.7.1169  0.271
2004 Scacheri PC, Kennedy AL, Chin K, Miller MT, Hodgson JG, Gray JW, Marx SJ, Spiegel AM, Collins FS. Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability. Cancer Research. 64: 7039-44. PMID 15466197 DOI: 10.1158/0008-5472.Can-04-1648  0.271
1999 Agarwal SK, Guru SC, Heppner C, Erdos MR, Collins RM, Park SY, Saggar S, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ, Burns AL. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell. 96: 143-52. PMID 9989505 DOI: 10.1016/S0092-8674(00)80967-8  0.271
1995 Dong Q, Shenker A, Way J, Haddad BR, Lin K, Hughes MR, McBride OW, Spiegel AM, Battey J. Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene. Genomics. 30: 470-75. PMID 8825633 DOI: 10.1006/Geno.1995.1267  0.271
1995 Shenker A, Chanson P, Weinstein LS, Chi P, Spiegel AM, Lomri A, Marie PJ. Osteoblastic cells derived from isolated lesions of fibrous dysplasia contain activating somatic mutations of the Gs alpha gene. Human Molecular Genetics. 4: 1675-6. PMID 8541861 DOI: 10.1093/Hmg/4.9.1675  0.27
1988 Backlund PS, Aksamit RR, Unson CG, Goldsmith P, Spiegel AM, Milligan G. Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line. Biochemistry. 27: 2040-6. PMID 3132205 DOI: 10.1021/Bi00406A034  0.269
2003 Hu J, Spiegel AM. Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function. Trends in Endocrinology and Metabolism: Tem. 14: 282-8. PMID 12890593 DOI: 10.1016/S1043-2760(03)00104-8  0.269
2003 Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C, Hager JH, Hanahan D, Edlund H, Magnuson MA, Garrett-Beal L, Burns AL, Ried T, Chandrasekharappa SC, Marx SJ, ... Spiegel AM, et al. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Molecular and Cellular Biology. 23: 6075-85. PMID 12917331 DOI: 10.1128/Mcb.23.17.6075-6085.2003  0.268
1985 Gierschik P, Codina J, Simons C, Birnbaumer L, Spiegel A. Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni. Proceedings of the National Academy of Sciences of the United States of America. 82: 727-31. PMID 3919382 DOI: 10.1073/Pnas.82.3.727  0.267
2001 Reyes-Cruz G, Hu J, Goldsmith PK, Steinbach PJ, Spiegel AM. Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants. The Journal of Biological Chemistry. 276: 32145-51. PMID 11399760 DOI: 10.1074/Jbc.M102977200  0.267
1995 Spiegel AM. G protein gene knockout hits the gut. Nature Medicine. 1: 522-4. PMID 7585115 DOI: 10.1038/Nm0695-522  0.267
1998 Ray K, Clapp P, Goldsmith PK, Spiegel AM. Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction. The Journal of Biological Chemistry. 273: 34558-67. PMID 9852126 DOI: 10.1074/Jbc.273.51.34558  0.266
2001 Scacheri PC, Crabtree JS, Novotny EA, Garrett-Beal L, Chen A, Edgemon KA, Marx SJ, Spiegel AM, Chandrasekharappa SC, Collins FS. Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice. Genesis (New York, N.Y. : 2000). 30: 259-63. PMID 11536432 DOI: 10.1002/Gene.1072  0.266
2003 Spiegel A. β-arrestin - Not just for G protein-coupled receptors Science. 301: 1338-1339. PMID 12958351 DOI: 10.1126/Science.1089552  0.264
1990 Cooper DMF, Boyajian CL, Goldsmith PK, Unson CG, Spiegel A. Differential expression of low molecular weight form of Gs-α in neostriatum and cerebellum: correlation with expression of calmodulin-independent adenylyl cyclase Brain Research. 523: 143-146. PMID 2119853 DOI: 10.1016/0006-8993(90)91648-Z  0.264
1990 Jones TL, Simonds WF, Merendino JJ, Brann MR, Spiegel AM. Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment. Proceedings of the National Academy of Sciences of the United States of America. 87: 568-72. PMID 2105488 DOI: 10.1073/Pnas.87.2.568  0.263
1987 Brann MR, Collins RM, Spiegel A. Localization of mRNAs encoding the α-subunits of signal-transducing G-proteins within rat brain and among peripheral tissues Febs Letters. 222: 191-198. PMID 3115828 DOI: 10.1016/0014-5793(87)80218-1  0.263
1986 Bray P, Carter A, Simons C, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M. Human cDNA clones for four species of G alpha s signal transduction protein. Proceedings of the National Academy of Sciences of the United States of America. 83: 8893-7. PMID 3024154 DOI: 10.1073/Pnas.83.23.8893  0.262
1997 Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, et al. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. Genome Research. 7: 725-35. PMID 9253601 DOI: 10.1101/Gr.7.7.725  0.262
1991 Spiegel AM, Backlund PS, Butrynski JE, Jones TL, Simonds WF. The G protein connection: molecular basis of membrane association. Trends in Biochemical Sciences. 16: 338-41. PMID 1949155 DOI: 10.1016/0968-0004(91)90139-M  0.262
1994 Wenkert D, Merendino JJ, Shenker A, Thambi N, Robertson GL, Moses AM, Spiegel AM. Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus. Human Molecular Genetics. 3: 1429-30. PMID 7987330 DOI: 10.1093/Hmg/3.8.1429  0.262
1987 Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M. Human cDNA clones for an alpha subunit of Gi signal-transduction protein. Proceedings of the National Academy of Sciences of the United States of America. 84: 5115-9. PMID 3110783 DOI: 10.1073/Pnas.84.15.5115  0.261
1986 Grunwald GB, Gierschik P, Nirenberg M, Spiegel A. Detection of alpha-transducin in retinal rods but not cones. Science (New York, N.Y.). 231: 856-9. PMID 3080807 DOI: 10.1126/Science.3080807  0.259
1986 Zick Y, Sagi-Eisenberg R, Pines M, Gierschik P, Spiegel AM. Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 83: 9294-7. PMID 3099281 DOI: 10.1073/Pnas.83.24.9294  0.259
1998 Bianco P, Kuznetsov SA, Riminucci M, Fisher LW, Spiegel AM, Robey PG. Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells. The Journal of Clinical Investigation. 101: 1737-44. PMID 9541505 DOI: 10.1172/Jci2361  0.258
1987 Lad RP, Simons C, Gierschik P, Milligan G, Woodard C, Griffo M, Goldsmith P, Ornberg R, Gerfen CR, Spiegel A. Differential distribution of signal-transducing G-proteins in retina. Brain Research. 423: 237-46. PMID 3119154 DOI: 10.1016/0006-8993(87)90845-6  0.258
1990 Murakami T, Rossiter K, Spiegel AM, Sacktor B. Erratum: Identification of multiple G(i) subtypes and a novel G protein in bovine kidney cortex (Biochemical Pharmacology, Vol. 38 (1989) 4502-4505) Biochemical Pharmacology. 39. DOI: 10.1016/0006-2952(90)90137-A  0.257
2007 Agarwal SK, Impey S, McWeeney S, Scacheri PC, Collins FS, Goodman RH, Spiegel AM, Marx SJ. Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia (New York, N.Y.). 9: 101-7. PMID 17356705 DOI: 10.1593/Neo.06706  0.257
1993 Spiegel AM, Weinstein LS, Shenker A. Abnormalities in G protein-coupled signal transduction pathways in human disease. The Journal of Clinical Investigation. 92: 1119-25. PMID 8397218 DOI: 10.1172/Jci116680  0.257
1992 Butrynski JE, Jones TL, Backlund PS, Spiegel AM. Differential isoprenylation of carboxy-terminal mutants of an inhibitory G-protein alpha-subunit: neither farnesylation nor geranylgeranylation is sufficient for membrane attachment. Biochemistry. 31: 8030-5. PMID 1510988 DOI: 10.1021/Bi00149A037  0.257
2003 Spiegel AM. G protein-regulated signaling dysfunction in human disease: A personal historical perspective Journal of Investigative Medicine. 51: 192-193. DOI: 10.1136/Jim-51-04-20  0.257
2000 Goebel SU, Peghini PL, Goldsmith P, Spiegel AM, Gibril F, Raffeld M, Serrano J, Jensen RT. Expression and function of the calcium sensing receptor (CaR) in gastrinomas Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)83276-X  0.257
2000 Hauache OM, Hu J, Ray K, Xie R, Jacobson KA, Spiegel AM. Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors. Endocrinology. 141: 4156-63. PMID 11089548 DOI: 10.1210/Endo.141.11.7753  0.255
1985 Pines M, Gierschik P, Spiegel AM. The tryptic and chymotryptic fragments of the β‐subunit of guanine nucleotide binding proteins in brain are identical to those of retinal transducin Febs Letters. 182: 355-359. PMID 3920073 DOI: 10.1016/0014-5793(85)80332-X  0.254
1992 Spiegel AM. Heterotrimeric GTP-binding proteins: an expanding family of signal transducers. Medicinal Research Reviews. 12: 55-71. PMID 1738245 DOI: 10.1002/Med.2610120105  0.253
1978 Spiegel AM, Rosen SW, Weintraub BD, Marynick SP. Effect of intravenous pyridoxine on plasma prolactin in hyperprolactinemic subjects. The Journal of Clinical Endocrinology and Metabolism. 46: 686-8. PMID 755053 DOI: 10.1210/Jcem-46-4-686  0.253
1998 Emmert-Buck MR, Debelenko LV, Agarwal S, Kester MB, Manickam P, Zhuang Z, Guru SC, Olufemi SE, Burns AL, Chandrasekharappa SC, Lubensky IA, Liotta LA, Skarulis MC, Spiegel AM, Marx SJ, et al. 11q13 allelotype analysis in 27 northern American MEN1 kindreds identifies two distinct founder chromosomes. Molecular Genetics and Metabolism. 63: 151-5. PMID 9562970 DOI: 10.1006/Mgme.1997.2649  0.252
1998 Marx SJ, Agarwal SK, Kester MB, Heppner C, Kim YS, Emmert-Buck MR, Debelenko LV, Lubensky IA, Zhuang Z, Guru SC, Manickam P, Olufemi SE, Skarulis MC, Doppman JL, Alexander RH, ... ... Spiegel AM, et al. Germline and somatic mutation of the gene for multiple endocrine neoplasia type 1 (MEN1). Journal of Internal Medicine. 243: 447-53. PMID 9681842 DOI: 10.1046/J.1365-2796.1998.00348.X  0.252
1987 Wright HN, Weinstock RS, Spiegel AM, Levine MA, Mosesc AM. Guanine Nucleotide-Binding Stimulatory Protein.: A Requisite for Human Odorant Perception Annals of the New York Academy of Sciences. 510: 719-722. DOI: 10.1111/J.1749-6632.1987.Tb43677.X  0.25
2002 Hu J, Reyes-Cruz G, Chen W, Jacobson KA, Spiegel AM. Identification of acidic residues in the extracellular loops of the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+ and a positive allosteric modulator. The Journal of Biological Chemistry. 277: 46622-31. PMID 12297503 DOI: 10.1074/Jbc.M207100200  0.25
1989 Simonds WF, Collins RM, Spiegel AM, Brann MR. Membrane attachment of recombinant G-protein alpha-subunits in excess of beta gamma subunits in a eukaryotic expression system. Biochemical and Biophysical Research Communications. 164: 46-53. PMID 2508638 DOI: 10.1016/0006-291X(89)91680-X  0.25
1989 Murakami T, Rossiter K, Spiegel AM, Sacktor B. Identification of multiple Gi subtypes and a novel G protein in bovine kidney cortex. Biochemical Pharmacology. 38: 4502-5. PMID 2513812 DOI: 10.1016/0006-2952(89)90664-3  0.249
1991 Gejman PV, Weinstein LS, Martinez M, Spiegel AM, Cao Q, Hsieh WT, Hoehe MR, Gershon ES. Genetic mapping of the Gs-alpha subunit gene (GNAS1) to the distal long arm of chromosome 20 using a polymorphism detected by denaturing gradient gel electrophoresis. Genomics. 9: 782-3. PMID 1674732 DOI: 10.1016/0888-7543(91)90377-Q  0.249
1987 Milligan G, Gierschik P, Spiegel AM. The use of specific antibodies to identify and quantify guanine nucleotide-binding proteins. Biochemical Society Transactions. 15: 42-5. PMID 3104112 DOI: 10.1042/Bst0150042  0.249
1997 Guru SC, Olufemi SE, Manickam P, Cummings C, Gieser LM, Pike BL, Bittner ML, Jiang Y, Chinault AC, Nowak NJ, Brzozowska A, Crabtree JS, Wang Y, Roe BA, Weisemann JM, ... ... Spiegel AM, et al. A 2.8-Mb clone contig of the multiple endocrine neoplasia type 1 (MEN1) region at 11q13. Genomics. 42: 436-45. PMID 9205115 DOI: 10.1006/Geno.1997.4783  0.249
1999 Kim YS, Burns AL, Goldsmith PK, Heppner C, Park SY, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ. Stable overexpression of MEN1 suppresses tumorigenicity of RAS. Oncogene. 18: 5936-42. PMID 10557080 DOI: 10.1038/Sj.Onc.1203005  0.248
1993 Hermouet S, Murakami T, Spiegel AM. Stable changes in expression or activation of G protein alpha i or alpha q subunits affect the expression of both beta 1 and beta 2 subunits. Febs Letters. 327: 183-8. PMID 8335108 DOI: 10.1016/0014-5793(93)80166-R  0.247
1997 Goldsmith PK, Fan G, Miller JL, Rogers KV, Spiegel AM. Monoclonal antibodies against synthetic peptides corresponding to the extracellular domain of the human Ca2+ receptor: characterization and use in studying concanavalin A inhibition. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 12: 1780-8. PMID 9383682 DOI: 10.1359/Jbmr.1997.12.11.1780  0.247
2007 Hu J, Reyes-Cruz G, Goldsmith PK, Gantt NM, Miller JL, Spiegel AM. Functional effects of monoclonal antibodies to the purified amino-terminal extracellular domain of the human Ca(2+) receptor. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 601-8. PMID 17243861 DOI: 10.1359/Jbmr.070111  0.246
2000 Hauache OM, Hu J, Ray K, Spiegel AM. Functional interactions between the extracellular domain and the seven-transmembrane domain in Ca2+ receptor activation. Endocrine. 13: 63-70. PMID 11051048 DOI: 10.1385/Endo:13:1:63  0.246
2003 Agarwal SK, Novotny EA, Crabtree JS, Weitzman JB, Yaniv M, Burns AL, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ. Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter. Proceedings of the National Academy of Sciences of the United States of America. 100: 10770-5. PMID 12960363 DOI: 10.1073/Pnas.1834524100  0.245
1999 Zhao XM, Hauache O, Goldsmith PK, Collins R, Spiegel AM. A missense mutation in the seventh transmembrane domain constitutively activates the human Ca2+ receptor. Febs Letters. 448: 180-4. PMID 10217436 DOI: 10.1016/S0014-5793(99)00368-3  0.243
1984 Tam CS, Heersche JN, Santora A, Spiegel AM. Skeletal response in rats following the implantation of hypercalcemia-producing Leydig cell tumors. Metabolism: Clinical and Experimental. 33: 50-3. PMID 6690886 DOI: 10.1016/0026-0495(84)90161-6  0.242
1986 van Veen T, Ostholm T, Gierschik P, Spiegel A, Somers R, Korf HW, Klein DC. alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates. Proceedings of the National Academy of Sciences of the United States of America. 83: 912-6. PMID 3513166 DOI: 10.1073/Pnas.83.4.912  0.24
1992 Murakami T, Simonds WF, Spiegel AM. Site-specific antibodies directed against G protein beta and gamma subunits: effects on alpha and beta gamma subunit interaction. Biochemistry. 31: 2905-11. PMID 1550816 DOI: 10.1021/Bi00126A009  0.24
1986 Pines M, Santora A, Spiegel AM. Effects of phorbol esters and pertussis toxin on agonist-stimulated cyclic AMP production in rat osteosarcoma cells. Biochemical Pharmacology. 35: 3639-3641. PMID 2429669 DOI: 10.1016/0006-2952(86)90638-6  0.238
2000 Feingold D, Alexander HR, Chen C, Libutti SK, Shawker T, Simonds W, Spiegel A, Marx S, Skarulis MC, Doppman JL, Bartlett DL. Ultrasonography and sestamibi as the only preoperative imaging tests in reoperation for parathyroid adenoma British Journal of Surgery. 87: 1272-1272. DOI: 10.1046/J.1365-2168.2000.01601-38.X  0.237
1988 McKenzie FR, Mullaney I, Unson CG, Spiegel AM, Milligan G. The use of anti-peptide antisera to probe interactions between receptors and guanine nucleotide binding proteins. Biochemical Society Transactions. 16: 434-7. PMID 2850230 DOI: 10.1042/Bst0160434  0.237
1987 Cerione RA, Gierschik P, Staniszewski C, Benovic JL, Codina J, Somers R, Birnbaumer L, Spiegel AM, Lefkowitz RJ, Caron MG. Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. Biochemistry. 26: 1485-91. PMID 3032251 DOI: 10.1021/Bi00379A041  0.237
2018 Spiegel AM. A double negative: inhibition of hepatic Gi signaling improves glucose homeostasis. The Journal of Clinical Investigation. PMID 29337307 DOI: 10.1172/Jci99037  0.236
2001 Valle MA, Kester MB, Burns AL, Marx SJ, Spiegel AM, Shiloach J. Production and purification of human menin from Drosophila melanogaster S2 cells using stirred tank reactor. Cytotechnology. 35: 127-35. PMID 19003289 DOI: 10.1023/A:1017586523710  0.235
2000 Hu J, Hauache O, Spiegel AM. Human Ca2+ receptor cysteine-rich domain. Analysis of function of mutant and chimeric receptors. The Journal of Biological Chemistry. 275: 16382-9. PMID 10747888 DOI: 10.1074/Jbc.M000277200  0.229
1978 Marx SJ, Spiegel AM, Brown EM, Gardner DG, Downs RW, Attie M, Hamstra AJ, DeLuca HF. A familial syndrome of decrease in sensitivity to 1,25-dihydroxyvitamin D. The Journal of Clinical Endocrinology and Metabolism. 47: 1303-10. PMID 233695 DOI: 10.1210/Jcem-47-6-1303  0.228
1981 Marx SJ, Attie MF, Levine MA, Spiegel AM, Downs RW, Lasker RD. The hypocalciuric or benign variant of familial hypercalcemia: clinical and biochemical features in fifteen kindreds. Medicine. 60: 397-412. PMID 7311809 DOI: 10.1097/00005792-198111000-00002  0.227
2007 Spiegel AM. Inherited endocrine diseases involving G proteins and G protein-coupled receptors. Endocrine Development. 11: 133-44. PMID 17986833 DOI: 10.1159/0000111069  0.224
1987 Gawler D, Milligan G, Spiegel AM, Unson CG, Houslay MD. Erratum: Abolition of the expression of inhibitory guanine nucleotide regulatory protein G i in diabetes Nature. 327: 732-732. DOI: 10.1038/327732B0  0.218
2001 Hu J, Reyes-Cruz G, Goldsmith PK, Spiegel AM. The Venus's-flytrap and cysteine-rich domains of the human Ca2+ receptor are not linked by disulfide bonds. The Journal of Biological Chemistry. 276: 6901-4. PMID 11238442 DOI: 10.1074/Jbc.C000865200  0.218
1976 Goar WTS, Paloyan E, Lawrence AM, Brennan MF, Marx SJ, Brown EM, Spiegel AM, Doppman JL, Clark OH, Wells SA, Ellis GJ, Gunnells JC, Schneider AB, Sherwood LM. Management of Primary Parathyroid Hyperplasia The New England Journal of Medicine. 295: 1202-1204. PMID 980031 DOI: 10.1056/Nejm197611182952121  0.217
1999 Spiegel AM. Hormone resistance caused by mutations in G proteins and G protein-coupled receptors. Journal of Pediatric Endocrinology & Metabolism : Jpem. 12: 303-9. PMID 10698594  0.215
2004 Spiegel AM. Focus on hereditary endocrine neoplasia. Cancer Cell. 6: 327-32. PMID 15488756 DOI: 10.1016/J.Ccr.2004.09.023  0.208
1994 Doppman JL, Shawker TH, Fraker DL, Alexander HR, Skarulis MC, Lack EE, Spiegel AM. Parathyroid adenoma within the vagus nerve. Ajr. American Journal of Roentgenology. 163: 943-5. PMID 8092040 DOI: 10.2214/Ajr.163.4.8092040  0.204
2002 Marx SJ, Simonds WF, Agarwal SK, Burns AL, Weinstein LS, Cochran C, Skarulis MC, Spiegel AM, Libutti SK, Alexander HR, Chen CC, Chang R, Chandrasekharappa SC, Collins FS. Hyperparathyroidism in hereditary syndromes: special expressions and special managements. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 17: N37-43. PMID 12412776  0.203
1996 Spiegel AM. Defects in G protein-coupled signal transduction in human disease. Annual Review of Physiology. 58: 143-70. PMID 8815789 DOI: 10.1146/annurev.ph.58.030196.001043  0.202
1994 Billingsley KG, Fraker DL, Doppman JL, Norton JA, Shawker TH, Skarulis MC, Marx SJ, Spiegel AM, Alexander HR. Localization and operative management of undescended parathyroid adenomas in patients with persistent primary hyperparathyroidism. Surgery. 116: 982-9; discussion 98. PMID 7985106  0.201
1994 MacFarlane MP, Fraker DL, Shawker TH, Norton JA, Doppman JL, Chang RA, Skarulis MC, Marx SJ, Spiegel AM, Alexander HR. Use of preoperative fine-needle aspiration in patients undergoing reoperation for primary hyperparathyroidism. Surgery. 116: 959-64; discussion 9. PMID 7985103  0.2
1996 Singer FR, Siris ES, Martinez S, Kaplan FS, Watts H, Spiegel AM, Bone HG, Meunier PJ, Chapurlat R, Delmas PD, Altman RD, McClung MR, Ryan WG, Wallach S, Cutler GB, et al. Abstracts from the symposium on recent advances in Paget’s disease of bone and related bone diseases Calcified Tissue International. 59: 219-227. DOI: 10.1007/Pl00005811  0.199
2006 Spiegel AM, Nabel EG. NIH research on obesity and type 2 diabetes: providing the scientific evidence base for actions to improve health. Nature Medicine. 12: 67-9. PMID 16397572 DOI: 10.1038/Nm0106-67  0.193
2005 Spiegel AM, Alving BM. Executive summary of the Strategic Plan for National Institutes of Health Obesity Research. The American Journal of Clinical Nutrition. 82: 211S-214S. PMID 16002822 DOI: 10.1093/Ajcn/82.1.221S  0.183
1993 LaMorte VJ, Harootunian AT, Spiegel AM, Tsien RY, Feramisco JR. Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2. The Journal of Cell Biology. 121: 91-9. PMID 8458876 DOI: 10.1083/Jcb.121.1.91  0.181
1995 Chen CC, Skarulis MC, Fraker DL, Alexander R, Marx SJ, Spiegel AM. Technetium-99m-sestamibi imaging before reoperation for primary hyperparathyroidism. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 36: 2186-91. PMID 8523102  0.179
2000 Pfäffle R, Blankenstein O, Wüller S, Heimann K, Heimann G, Moriwake T, Tanaka H, Spiegel AM, Burger HG, Lamberts SWJ, Eiholzer U, Bachmann S, l’Allemand D, Saggese G, Baroncelli GI, et al. Subject Index Vol. 53, Suppl. 3, 2000 Hormone Research in Paediatrics. 53: 94-94. DOI: 10.1159/000023542  0.178
1991 Spiegel AM. Pathophysiology of primary hyperparathyroidism. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 6: S15-7; discussion S3. PMID 1763667 DOI: 10.1002/jbmr.5650061407  0.178
1992 LaMorte VJ, Goldsmith PK, Spiegel AM, Meinkoth JL, Feramisco JR. Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies. The Journal of Biological Chemistry. 267: 691-4. PMID 1730660  0.177
1991 Shenker A, Goldsmith P, Unson CG, Spiegel AM. The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family. The Journal of Biological Chemistry. 266: 9309-13. PMID 1851174  0.176
1992 Meinkoth JL, Goldsmith PK, Spiegel AM, Feramisco JR, Burrow GN. Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs. The Journal of Biological Chemistry. 267: 13239-45. PMID 1377681  0.174
2005 Spiegel A, Nabel E, Volkow N, Landis S, Li TK. Obesity on the brain Nature Neuroscience. 8: 552-553. PMID 15856061 DOI: 10.1038/Nn0505-552  0.173
1997 Zhuang Z, Ezzat SZ, Vortmeyer AO, Weil R, Oldfield EH, Park WS, Pack S, Huang S, Agarwal SK, Guru SC, Manickam P, Debelenko LV, Kester MB, Olufemi SE, Heppner C, ... ... Spiegel AM, et al. Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Research. 57: 5446-51. PMID 9407947  0.172
1993 Spiegel AM. Gerald D. Aurbach, 1927-1991 Vitamins and Hormones. 47: xi-xii. DOI: 10.1016/S0083-6729(08)60443-4  0.171
2009 Spiegel AM, Marx SJ, Melton JL. Discussion section I Journal of Bone and Mineral Research. 6. DOI: 10.1002/Jbmr.5650061410  0.171
2007 Hu J, Spiegel AM. Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators. Journal of Cellular and Molecular Medicine. 11: 908-22. PMID 17979873 DOI: 10.1111/j.1582-4934.2007.00096.x  0.171
1996 Lubensky IA, Debelenko LV, Zhuang Z, Emmert-Buck MR, Dong Q, Chandrasekharappa S, Guru SC, Manickam P, Olufemi SE, Marx SJ, Spiegel AM, Collins FS, Liotta LA. Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients. Cancer Research. 56: 5272-8. PMID 8912868  0.17
1997 Spiegel AM. Inborn errors of signal transduction: mutations in G proteins and G protein-coupled receptors as a cause of disease. Journal of Inherited Metabolic Disease. 20: 113-21. PMID 9211183 DOI: 10.1023/A:1005393501786  0.169
1991 Cormont M, Le Marchand-Brustel Y, Van Obberghen E, Spiegel AM, Sharp GW. Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor. Diabetes. 40: 1170-6. PMID 1718802  0.167
1999 Vortmeyer AO, Lubensky IA, Skarulis M, Li G, Moon YW, Park WS, Weil R, Barlow C, Spiegel AM, Marx SJ, Zhuang Z. Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 12: 919-24. PMID 10496602  0.162
1993 Pamukcu R, Spiegel AM, Chang EB. Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte. The Journal of Laboratory and Clinical Medicine. 121: 689-96. PMID 8478596  0.158
2003 Libutti SK, Crabtree JS, Lorang D, Burns AL, Mazzanti C, Hewitt SM, O'Connor S, Ward JM, Emmert-Buck MR, Remaley A, Miller M, Turner E, Alexander HR, Arnold A, Marx SJ, ... ... Spiegel AM, et al. Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Cancer Research. 63: 8022-8. PMID 14633735  0.156
1999 Marx SJ, Agarwal SK, Kester MB, Heppner C, Kim YS, Skarulis MC, James LA, Goldsmith PK, Saggar SK, Park SY, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, et al. Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias. Recent Progress in Hormone Research. 54: 397-438; discussion . PMID 10548885  0.153
2015 Hannan FM, Walls GV, Babinsky VN, Nesbit MA, Kallay E, Hough TA, Fraser WD, Cox RD, Hu J, Spiegel AM, Thakker RV. The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing-receptor (CaSR) mutation: relevance to autosomal dominant hypocalcemia type 1 (ADH1). Endocrinology. en20151269. PMID 26052899 DOI: 10.1210/en.2015-1269  0.15
1995 Buell JF, Fraker DL, Doppman JL, Shawker TH, Skarulis MC, Spiegel AM, Marx SJ, Alexander HR. High cervical intravagal hypercellular parathyroid gland as the etiology of severe persistent primary hyperparathyroidism. The American Surgeon. 61: 943-6. PMID 7486421  0.15
2016 Babinsky VN, Hannan FM, Gorvin CM, Howles SA, Nesbit MA, Rust N, Hanyaloglu AC, Hu J, Spiegel AM, Thakker RV. Allosteric Modulation of the Calcium-Sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein alpha-11 Mutations causing Hypercalcemic and Hypocalcemic Disorders. The Journal of Biological Chemistry. PMID 26994139 DOI: 10.1074/jbc.M115.696401  0.148
1992 Chiavaroli C, Cooper DMF, Boyajian CL, Murray-Whelan R, Demaurex N, Spiegel AM, Schlegel W. Spontaneous intracellular calcium oscillations and G(s)α subunit expression are inversely correlated with secretory granule content in pituitary cells Journal of Neuroendocrinology. 4: 473-481.  0.143
1997 Emmert-Buck MR, Lubensky IA, Dong Q, Manickam P, Guru SC, Kester MB, Olufemi SE, Agarwal S, Burns AL, Spiegel AM, Collins FS, Marx SJ, Zhuang Z, Liotta LA, Chandrasekharappa SC, et al. Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis. Cancer Research. 57: 1855-8. PMID 9157974  0.142
1993 Degtyarev MY, Spiegel AM, Jones TL. Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin. The Journal of Biological Chemistry. 268: 23769-72. PMID 8226908  0.138
1994 Abou-Samra AB, Goldsmith PK, Xie LY, Jüppner H, Spiegel AM, Segre GV. Down-regulation of parathyroid (PTH)/PTH-related peptide receptor immunoreactivity and PTH binding in opossum kidney cells by PTH and dexamethasone. Endocrinology. 135: 2588-94. PMID 7988447 DOI: 10.1210/endo.135.6.7988447  0.137
1994 Degtyarev MY, Spiegel AM, Jones TL. Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation. The Journal of Biological Chemistry. 269: 30898-903. PMID 7983022  0.134
1991 Simonds WF, Butrynski JE, Gautam N, Unson CG, Spiegel AM. G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain. The Journal of Biological Chemistry. 266: 5363-6. PMID 1706334  0.133
1997 Debelenko LV, Zhuang Z, Emmert-Buck MR, Chandrasekharappa SC, Manickam P, Guru SC, Marx SJ, Skarulis MC, Spiegel AM, Collins FS, Jensen RT, Liotta LA, Lubensky IA. Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors. Cancer Research. 57: 2238-43. PMID 9187127  0.131
1998 Guru SC, Manickam P, Crabtree JS, Olufemi SE, Agarwal SK, Debelenko LV, Zhuang Z, Lubensky IA, Kester MB, Kim YS, Heppner C, Weisemann JM, Boguski MS, Wang Y, Roe BA, ... ... Spiegel AM, et al. Identification and characterization of the multiple endocrine neoplasia type 1 (MEN1) gene Journal of Internal Medicine. 243: 433-439. PMID 9681840 DOI: 10.1046/j.1365-2796.1998.00346.x  0.131
1997 Ray K, Fan GF, Goldsmith PK, Spiegel AM. Mutational analysis of the carboxyl-terminal region of the human calcium-sensing receptor Faseb Journal. 11: A1168.  0.13
1997 Zhuang Z, Vortmeyer AO, Pack S, Huang S, Pham TA, Wang C, Park WS, Agarwal SK, Debelenko LV, Kester M, Guru SC, Manickam P, Olufemi SE, Yu F, Heppner C, ... ... Spiegel AM, et al. Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Research. 57: 4682-6. PMID 9354421  0.129
1997 Riminucci M, Fisher LW, Shenker A, Spiegel AM, Bianco P, Gehron Robey P. Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. The American Journal of Pathology. 151: 1587-600. PMID 9403710  0.128
1997 Heppner C, Kester MB, Agarwal SK, Debelenko LV, Emmert-Buck MR, Guru SC, Manickam P, Olufemi SE, Skarulis MC, Doppman JL, Alexander RH, Kim YS, Saggar SK, Lubensky IA, Zhuang Z, ... ... Spiegel AM, et al. Somatic mutation of the MEN1 gene in parathyroid tumours. Nature Genetics. 16: 375-8. PMID 9241276 DOI: 10.1038/ng0897-375  0.128
1991 Hamilton SL, Codina J, Hawkes MJ, Yatani A, Sawada T, Strickland FM, Froehner SC, Spiegel AM, Toro L, Stefani E. Evidence for direct interaction of Gs alpha with the Ca2+ channel of skeletal muscle. The Journal of Biological Chemistry. 266: 19528-35. PMID 1655789  0.124
2015 Spiegel AM. Foreword Hypoparathyroidism. v-vi. DOI: 10.1007/978-88-470-5376-2  0.12
1991 Shenker A, Goldsmith P, Unson CG, Spiegel AM. The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family. Transactions of the Association of American Physicians. 104: 11-20. PMID 1845138  0.114
1992 Spiegel AM. Role of G proteins in signal transduction. Clinical Neuropharmacology. 15: 200A-201A. PMID 1498810  0.105
1993 Spiegel AM, Weinstein LS, Shenker A, Hermouet S, Merendino JJ. G proteins: from basic to clinical studies. Advances in Second Messenger and Phosphoprotein Research. 28: 37-46. PMID 8398416  0.105
1996 Wenkert D, Schoneberg T, Merendino JJ, Pena M, Vinitsky R, Goldsmith PK, Wess J, Spiegel AM. Expression and functional characterization of five v2 vasopressin receptor gene mutations identified in families with x-linked nephrogenic diabetes insipidus Journal of Investigative Medicine. 44: 225a.  0.102
1997 Manickam P, Guru SC, Debelenko LV, Agarwal SK, Olufemi SE, Weisemann JM, Boguski MS, Crabtree JS, Wang Y, Roe BA, Lubensky IA, Zhuang Z, Kester MB, Burns AL, Spiegel AM, et al. Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region. Human Genetics. 101: 102-8. PMID 9385379 DOI: 10.1007/s004390050595  0.098
1997 Debelenko LV, Emmert-Buck MR, Manickam P, Kester M, Guru SC, DiFranco EM, Olufemi SE, Agarwal S, Lubensky IA, Zhuang Z, Burns AL, Spiegel AM, Liotta LA, Collins FS, Marx SJ, et al. Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene. Cancer Research. 57: 1039-42. PMID 9067266  0.096
2010 Spiegel AM, Libutti SK. Future diagnostic and therapeutic trends in endocrine cancers. Seminars in Oncology. 37: 691-5. PMID 21167386 DOI: 10.1053/j.seminoncol.2010.10.020  0.094
1999 Ray K, Hauschild BC, Steinbach PJ, Goldsmith PK, Hauache O, Spiegel AM. Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca(2+) receptor critical for dimerization. Implications for function of monomeric Ca(2+) receptor. The Journal of Biological Chemistry. 274: 27642-50. PMID 10488104 DOI: 10.1074/jbc.274.39.27642  0.094
1997 Rodriguez Penn MS, Woodard C, Collins R, Spiegel A. Decreased insulin content and secretion in rin 1046-38 cells overexpressing α a2-adrenergic receptors Faseb Journal. 11: A1161.  0.072
2011 Spiegel AM, Libutti SK. Targeted therapies: Good news for advanced-stage pancreatic neuroendocrine tumors. Nature Reviews. Clinical Oncology. 8: 258-9. PMID 21448150 DOI: 10.1038/nrclinonc.2011.50  0.065
2013 Spiegel AM. The stem cell wars: a dispatch from the front. Transactions of the American Clinical and Climatological Association. 124: 94-110. PMID 23874014  0.045
2013 Spiegel AM, Koh MT, Vogt NM, Rapp PR, Gallagher M. Hilar interneuron vulnerability distinguishes aged rats with memory impairment. The Journal of Comparative Neurology. 521: 3508-23. PMID 23749483 DOI: 10.1002/cne.23367  0.045
2013 Weinstein LS, Collins MT, Spiegel AM. Gsα, Pseudohypoparathyroidism, Fibrous Dysplasia, and McCune-Albright Syndrome Genetics of Bone Biology and Skeletal Disease. 425-440. DOI: 10.1016/B978-0-12-387829-8.00027-5  0.044
2005 Elson CO, Ballew M, Barnard JA, Bernstein SJ, Check IJ, Cohen MB, Fazio S, Johanson JF, Lindor NM, Montgomery E, Richardson LH, Rogers D, Vijan S, Bushara KO, Case S, ... ... Spiegel AM, et al. National Institutes of Health Consensus Development Conference statement on Celiac Disease, June 28-30, 2004 Gastroenterology. 128: S1-S9. PMID 15825115 DOI: 10.1053/j.gastro.2005.02.007  0.038
2012 Spiegel AM, Hawkins M. 'Personalized medicine' to identify genetic risks for type 2 diabetes and focus prevention: can it fulfill its promise? Health Affairs (Project Hope). 31: 43-9. PMID 22232093 DOI: 10.1377/Hlthaff.2011.1054  0.037
2002 Spiegel AD, Spiegel AM. Abraham and Mary Lincoln: Insanity in and out of the courtroom American Journal of Forensic Psychiatry. 23: 53-69.  0.035
2014 Koh MT, Spiegel AM, Gallagher M. Age-associated changes in hippocampal-dependent cognition in Diversity Outbred mice. Hippocampus. 24: 1300-7. PMID 24909986 DOI: 10.1002/hipo.22311  0.029
2012 Stranahan AM, Jiam NT, Spiegel AM, Gallagher M. Aging reduces total neuron number in the dorsal component of the rodent prefrontal cortex. The Journal of Comparative Neurology. 520: 1318-26. PMID 22020730 DOI: 10.1002/Cne.22790  0.028
1999 Spiegel AM. Citation for the 1999 Monsanto Clinical Investigator Lecture Award of the Endocrine Society to Dr. Stephen J. Marx. Endocrine Reviews. 20: 590-1. PMID 10453362  0.028
2014 Spiegel AM, Sewal AS, Rapp PR. Epigenetic contributions to cognitive aging: disentangling mindspan and lifespan. Learning & Memory (Cold Spring Harbor, N.Y.). 21: 569-74. PMID 25227252 DOI: 10.1101/lm.033506.113  0.026
2010 Spiegel AM. Commentary: new guidelines for NIH peer review: improving the system or undermining it? Academic Medicine : Journal of the Association of American Medical Colleges. 85: 746-8. PMID 20520019 DOI: 10.1097/ACM.0b013e3181d7e130  0.025
2000 Spiegel AD, Spiegel AM. For the first time in a U.S. Court: A murderer's temporary insanity plea American Journal of Forensic Psychiatry. 21: 3-30.  0.022
1997 Spiegel AM. Citation for the 1997 Gerald D. Aurbach Lecture Award of The Endocrine Society to Edward M. Brown. Endocrine Reviews. 18: 616-7. PMID 9267769  0.018
2015 Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, ... ... Spiegel AM, et al. Research in academic medical centers: two threats to sustainable support. Science Translational Medicine. 7: 289fs22. PMID 26019216 DOI: 10.1126/Scitranslmed.Aac5200  0.016
2001 Alavi A, Chamberlain J, Cherrington AD, Convit A, Craft S, Cryer PE, Davis SN, Davison S, De Leon M, DeRosa M, Drucker D, Albert M, Evans M, Feldman E, Fischbach GD, ... ... Spiegel AM, et al. Workshop on hypoglycemia and the brain Diabetes Technology and Therapeutics. 3: 469-516. DOI: 10.1089/15209150152607259  0.013
2019 Spiegel AM. THE JEREMIAH METZGER LECTURE: A BRIEF HISTORY OF EUGENICS IN AMERICA: IMPLICATIONS FOR MEDICINE IN THE 21 CENTURY. Transactions of the American Clinical and Climatological Association. 130: 216-234. PMID 31516187  0.01
2015 Spiegel AM. Young Islam: The new politics of religion in Morocco and the Arab World Young Islam: the New Politics of Religion in Morocco and the Arab World. 1-246.  0.01
2008 Spiegel A. Albert Einstein College of Medicine Academic Medicine : Journal of the Association of American Medical Colleges. 83: 524. PMID 18448914  0.01
1992 Spiegel AD, Spiegel AM. Was it murder or insanity? Reactions to a successful paroxysmal insanity plea in 1865. Women & Health. 18: 69-86. PMID 1632102 DOI: 10.1300/J013v18n02_05  0.01
1992 Potts JT, Spiegel AM. In memoriam Gerald D. Aurbach. Molecular Endocrinology (Baltimore, Md.). 6: 1982-4. PMID 1480184 DOI: 10.1210/mend.6.11.1480184  0.01
1992 Potts JT, Spiegel AM. In memoriam Gerald D. Aurbach. The Journal of Clinical Endocrinology and Metabolism. 75: 1386-8. PMID 1430101 DOI: 10.1210/jcem.75.5.1430101  0.01
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