Charles Chavkin - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
Area:
Opioid receptors, potassium channels

150 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Fontaine HM, Silva PR, Neiswanger C, Tran R, Abraham AD, Land BB, Neumaier JF, Chavkin C. Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT receptors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34564712 DOI: 10.1038/s41386-021-01178-0  0.801
2021 Abraham AD, Casello SM, Schattauer SS, Wong BA, Mizuno GO, Mahe K, Tian L, Land BB, Chavkin C. Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34545197 DOI: 10.1038/s41386-021-01168-2  0.817
2020 Steger JS, Land BB, Lemos JC, Chavkin C, Phillips PEM. Insidious Transmission of a Stress-Related Neuroadaptation. Frontiers in Behavioral Neuroscience. 14: 564054. PMID 33132859 DOI: 10.3389/fnbeh.2020.564054  0.697
2020 Reichard KL, Newton KA, Rivera ZMG, Sotero de Menezes PM, Schattauer SS, Land BB, Chavkin C. . Molecular Pharmacology. PMID 32913138 DOI: 10.1124/Molpharm.120.000124  0.834
2020 Lesiak AJ, Coffey K, Cohen JH, Liang KJ, Chavkin C, Neumaier JF. Sequencing the serotonergic neuron translatome reveals a new role for Fkbp5 in stress. Molecular Psychiatry. PMID 32366949 DOI: 10.1038/S41380-020-0750-4  0.788
2019 Heymann G, Jo YS, Reichard KL, McFarland N, Chavkin C, Palmiter RD, Soden ME, Zweifel LS. Synergy of Distinct Dopamine Projection Populations in Behavioral Reinforcement. Neuron. PMID 31879163 DOI: 10.1016/J.Neuron.2019.11.024  0.306
2019 Schattauer SS, Bedini A, Summers F, Reilly-Treat A, Andrews MM, Land BB, Chavkin C. ROS generation is stimulated by kappa opioid receptor activation through phosphorylated c-Jun-N-terminal kinase and inhibited by p38 MAPK activation. The Journal of Biological Chemistry. PMID 31575661 DOI: 10.1074/Jbc.Ra119.009592  0.829
2019 Chavkin C, Cohen JH, Land BB. Repeated Administration of Norbinaltorphimine Produces Cumulative Kappa Opioid Receptor Inactivation. Frontiers in Pharmacology. 10: 88. PMID 30787880 DOI: 10.3389/Fphar.2019.00088  0.741
2019 Borsodi A, Bruchas M, Caló G, Chavkin C, Christie MJ, Civelli O, Connor M, Cox BM, Devi LA, Evans C, Höllt V, Henderson G, Husbands S, Kelly E, Kieffer B, et al. Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f50/2019.4  0.816
2018 Abraham AD, Schattauer SS, Reichard KL, Cohen JH, Fontaine HM, Song AJ, Johnson SD, Land BB, Chavkin C. Estrogen regulation of GRK2 inactivates kappa opioid receptor signaling mediating analgesia, but not aversion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30076211 DOI: 10.1523/Jneurosci.0653-18.2018  0.818
2017 Schattauer SS, Land BB, Reichard KL, Abraham AD, Burgeno LM, Kuhar JR, Phillips PEM, Ong SE, Chavkin C. Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase. Nature Communications. 8: 743. PMID 28963507 DOI: 10.1038/S41467-017-00791-2  0.821
2017 Abraham AD, Fontaine HM, Song AJ, Andrews MM, Baird MA, Kieffer BL, Land BB, Chavkin C. Kappa Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral Inhibition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28649993 DOI: 10.1038/Npp.2017.133  0.767
2017 Schattauer SS, Kuhar JR, Song A, Chavkin C. Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor. Cellular Signalling. PMID 28088389 DOI: 10.1016/J.Cellsig.2017.01.016  0.84
2016 Chavkin C, Koob GF. Dynorphin, Dysphoria, and Dependence: the Stress of Addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 41: 373-4. PMID 26657953 DOI: 10.1038/npp.2015.258  0.477
2015 Ehrich JM, Messinger DI, Knakal CR, Kuhar JR, Schattauer SS, Bruchas MR, Zweifel LS, Kieffer BL, Phillips PE, Chavkin C. Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 12917-31. PMID 26377476 DOI: 10.1523/Jneurosci.2444-15.2015  0.812
2015 Kuhar JR, Bedini A, Melief EJ, Chiu YC, Striegel HN, Chavkin C. Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms. Cellular Signalling. 27: 1799-806. PMID 26056051 DOI: 10.1016/J.Cellsig.2015.05.019  0.834
2015 Lowe JD, Sanderson HS, Cooke AE, Ostovar M, Tsisanova E, Withey SL, Chavkin C, Husbands SM, Kelly E, Henderson G, Bailey CP. Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization. Molecular Pharmacology. 88: 347-56. PMID 26013542 DOI: 10.1124/Mol.115.098293  0.636
2015 Oakley AE, Steiner RA, Chavkin C, Clifton DK, Ferrara LK, Reed SD. κ Agonists as a novel therapy for menopausal hot flashes. Menopause (New York, N.Y.). PMID 25988798 DOI: 10.1097/Gme.0000000000000476  0.502
2015 Groblewski PA, Zietz C, Willuhn I, Phillips PE, Chavkin C. Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats. Addiction Biology. 20: 297-301. PMID 24919534 DOI: 10.1111/adb.12123  0.555
2014 Chavkin C, Ehrich JM. How does stress-induced activation of the kappa opioid system increase addiction risk? Biological Psychiatry. 76: 760-2. PMID 25442057 DOI: 10.1016/J.Biopsych.2014.08.015  0.765
2014 Ehrich JM, Phillips PE, Chavkin C. Kappa opioid receptor activation potentiates the cocaine-induced increase in evoked dopamine release recorded in vivo in the mouse nucleus accumbens. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 3036-48. PMID 24971603 DOI: 10.1038/Npp.2014.157  0.797
2014 Chavkin C, Schattauer SS, Levin JR. Arrestin-mediated activation of p38 MAPK: molecular mechanisms and behavioral consequences. Handbook of Experimental Pharmacology. 219: 281-92. PMID 24292835 DOI: 10.1007/978-3-642-41199-1_14  0.817
2013 Soden ME, Jones GL, Sanford CA, Chung AS, Güler AD, Chavkin C, Luján R, Zweifel LS. Disruption of dopamine neuron activity pattern regulation through selective expression of a human KCNN3 mutation. Neuron. 80: 997-1009. PMID 24206670 DOI: 10.1016/J.Neuron.2013.07.044  0.353
2013 Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ. Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacological Reviews. 65: 223-54. PMID 23321159 DOI: 10.1124/Pr.112.005942  0.701
2012 Schindler AG, Messinger DI, Smith JS, Shankar H, Gustin RM, Schattauer SS, Lemos JC, Chavkin NW, Hagan CE, Neumaier JF, Chavkin C. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17582-96. PMID 23223282 DOI: 10.1523/Jneurosci.3220-12.2012  0.801
2012 Schattauer SS, Miyatake M, Shankar H, Zietz C, Levin JR, Liu-Chen LY, Gurevich VV, Rieder MJ, Chavkin C. Ligand directed signaling differences between rodent and human κ-opioid receptors. The Journal of Biological Chemistry. 287: 41595-607. PMID 23086943 DOI: 10.1074/Jbc.M112.381368  0.826
2012 Lemos JC, Wanat MJ, Smith JS, Reyes BA, Hollon NG, Van Bockstaele EJ, Chavkin C, Phillips PE. Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. Nature. 490: 402-6. PMID 22992525 DOI: 10.1038/nature11436  0.669
2012 Lemos JC, Roth CA, Messinger DI, Gill HK, Phillips PE, Chavkin C. Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 12325-36. PMID 22956823 DOI: 10.1523/JNEUROSCI.2053-12.2012  0.73
2012 Smith JS, Schindler AG, Martinelli E, Gustin RM, Bruchas MR, Chavkin C. Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1488-95. PMID 22279233 DOI: 10.1523/Jneurosci.2980-11.2012  0.753
2012 Hays SL, McPherson RJ, Juul SE, Wallace G, Schindler AG, Chavkin C, Gleason CA. Long-term effects of neonatal stress on adult conditioned place preference (CPP) and hippocampal neurogenesis. Behavioural Brain Research. 227: 7-11. PMID 22061798 DOI: 10.1016/J.Bbr.2011.10.033  0.633
2012 Lemos J, Wanat M, Smith J, Reyes B, Bockstaele EV, Chavkin C, Phillips P. Stress exposure produces a switch from appetitive to aversive signaling by corticotropin-releasing factor in the nucleus accumbens F1000research. 3. DOI: 10.7490/F1000Research.1089804.1  0.644
2011 Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB, Lemos JC, Hagan CE, Neumaier JF, Quintana A, Palmiter RD, Chavkin C. Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron. 71: 498-511. PMID 21835346 DOI: 10.1016/J.Neuron.2011.06.011  0.791
2011 Melief EJ, Miyatake M, Carroll FI, Béguin C, Carlezon WA, Cohen BM, Grimwood S, Mitch CH, Rorick-Kehn L, Chavkin C. Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation. Molecular Pharmacology. 80: 920-9. PMID 21832171 DOI: 10.1124/Mol.111.074195  0.79
2011 Lemos JC, Roth CA, Chavkin C. Signaling events initiated by kappa opioid receptor activation: quantification and immunocolocalization using phospho-selective KOR, p38 MAPK, and K(IR) 3.1 antibodies. Methods in Molecular Biology (Clifton, N.J.). 717: 197-219. PMID 21370032 DOI: 10.1007/978-1-61779-024-9_11  0.631
2010 Lyssand JS, Whiting JL, Lee KS, Kastl R, Wacker JL, Bruchas MR, Miyatake M, Langeberg LK, Chavkin C, Scott JD, Gardner RG, Adams ME, Hague C. Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome. Proceedings of the National Academy of Sciences of the United States of America. 107: 21854-9. PMID 21115837 DOI: 10.1073/Pnas.1010819107  0.607
2010 Reyes BA, Chavkin C, Van Bockstaele EJ. Agonist-induced internalization of κ-opioid receptors in noradrenergic neurons of the rat locus coeruleus. Journal of Chemical Neuroanatomy. 40: 301-9. PMID 20884346 DOI: 10.1016/j.jchemneu.2010.09.003  0.434
2010 Melief EJ, Miyatake M, Bruchas MR, Chavkin C. Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 107: 11608-13. PMID 20534436 DOI: 10.1073/Pnas.1000751107  0.844
2010 Schindler AG, Li S, Chavkin C. Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1932-42. PMID 20445500 DOI: 10.1038/Npp.2010.67  0.629
2010 Bruchas MR, Chavkin C. Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology. 210: 137-47. PMID 20401607 DOI: 10.1007/S00213-010-1806-Y  0.576
2010 Aita M, Byers MR, Chavkin C, Xu M. Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice. Molecular Pain. 6: 8. PMID 20109235 DOI: 10.1186/1744-8069-6-8  0.374
2010 Clayton CC, Bruchas MR, Lee ML, Chavkin C. Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy. Molecular Pharmacology. 77: 339-47. PMID 19959593 DOI: 10.1124/Mol.109.060558  0.696
2010 Bruchas MR, Land BB, Chavkin C. The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Research. 1314: 44-55. PMID 19716811 DOI: 10.1016/J.Brainres.2009.08.062  0.742
2009 Bruchas MR, Land BB, Lemos JC, Chavkin C. CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. Plos One. 4: e8528. PMID 20052275 DOI: 10.1371/Journal.Pone.0008528  0.812
2009 Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proceedings of the National Academy of Sciences of the United States of America. 106: 19168-73. PMID 19864633 DOI: 10.1073/Pnas.0910705106  0.818
2009 Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA. Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11859-66. PMID 19776272 DOI: 10.1523/Jneurosci.1569-09.2009  0.522
2009 Clayton CC, Xu M, Chavkin C. Tyrosine phosphorylation of Kir3 following kappa-opioid receptor activation of p38 MAPK causes heterologous desensitization. The Journal of Biological Chemistry. 284: 31872-81. PMID 19773548 DOI: 10.1074/jbc.M109.053793  0.405
2009 Vien TN, Gleason CA, Hays SL, McPherson RJ, Chavkin C, Juul SE. Effects of neonatal stress and morphine on kappa opioid receptor signaling. Neonatology. 96: 235-43. PMID 19478529 DOI: 10.1159/000220763  0.445
2009 Beaudry H, Proteau-Gagné A, Li S, Dory Y, Chavkin C, Gendron L. Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodents. Neuroscience. 161: 381-91. PMID 19328839 DOI: 10.1016/J.Neuroscience.2009.03.053  0.818
2009 Wang Y, Xu W, Huang P, Chavkin C, Van Bockstaele EJ, Liu-Chen LY. Effects of acute agonist treatment on subcellular distribution of kappa opioid receptor in rat spinal cord. Journal of Neuroscience Research. 87: 1695-702. PMID 19130621 DOI: 10.1002/jnr.21971  0.333
2009 Reyes BA, Chavkin C, van Bockstaele EJ. Subcellular targeting of kappa-opioid receptors in the rat nucleus locus coeruleus. The Journal of Comparative Neurology. 512: 419-31. PMID 19009591 DOI: 10.1002/cne.21880  0.355
2008 Bruchas MR, Xu M, Chavkin C. Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2. Neuroreport. 19: 1417-22. PMID 18766023 DOI: 10.1097/Wnr.0B013E32830Dd655  0.699
2008 Redila VA, Chavkin C. Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology. 200: 59-70. PMID 18575850 DOI: 10.1007/s00213-008-1122-y  0.46
2008 Kreibich A, Reyes BA, Curtis AL, Ecke L, Chavkin C, Van Bockstaele EJ, Valentino RJ. Presynaptic inhibition of diverse afferents to the locus ceruleus by kappa-opiate receptors: a novel mechanism for regulating the central norepinephrine system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6516-25. PMID 18562623 DOI: 10.1523/Jneurosci.0390-08.2008  0.653
2008 Land BB, Bruchas MR, Lemos JC, Xu M, Melief EJ, Chavkin C. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 407-14. PMID 18184783 DOI: 10.1523/Jneurosci.4458-07.2008  0.828
2008 Thomson LM, Terman GW, Zeng J, Lowe J, Chavkin C, Hermes SM, Hegarty DM, Aicher SA. Decreased substance P and NK1 receptor immunoreactivity and function in the spinal cord dorsal horn of morphine-treated neonatal rats. The Journal of Pain : Official Journal of the American Pain Society. 9: 11-9. PMID 17950674 DOI: 10.1016/J.Jpain.2007.07.008  0.378
2007 Gendron L, Pintar JE, Chavkin C. Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia. Neuroscience. 150: 807-17. PMID 17997230 DOI: 10.1016/J.Neuroscience.2007.09.060  0.729
2007 Bruchas MR, Land BB, Aita M, Xu M, Barot SK, Li S, Chavkin C. Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11614-23. PMID 17959804 DOI: 10.1523/Jneurosci.3769-07.2007  0.814
2007 Drake CT, Chavkin C, Milner TA. Opioid systems in the dentate gyrus. Progress in Brain Research. 163: 245-63. PMID 17765723 DOI: 10.1016/S0079-6123(07)63015-5  0.454
2007 Bruchas MR, Yang T, Schreiber S, Defino M, Kwan SC, Li S, Chavkin C. Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. The Journal of Biological Chemistry. 282: 29803-11. PMID 17702750 DOI: 10.1074/Jbc.M705540200  0.705
2007 Petraschka M, Li S, Gilbert TL, Westenbroek RE, Bruchas MR, Schreiber S, Lowe J, Low MJ, Pintar JE, Chavkin C. The absence of endogenous beta-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation. Neuroscience. 146: 1795-807. PMID 17467916 DOI: 10.1016/J.Neuroscience.2007.03.029  0.801
2007 Xu M, Bruchas MR, Ippolito DL, Gendron L, Chavkin C. Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2570-81. PMID 17344394 DOI: 10.1523/Jneurosci.3728-06.2007  0.803
2006 Li S, Lee ML, Bruchas MR, Chan GC, Storm DR, Chavkin C. Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses. Molecular Pharmacology. 70: 1742-9. PMID 16914643 DOI: 10.1124/Mol.106.025783  0.652
2006 Bruchas MR, Macey TA, Lowe JD, Chavkin C. Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. The Journal of Biological Chemistry. 281: 18081-9. PMID 16648139 DOI: 10.1074/Jbc.M513640200  0.576
2006 McLaughlin JP, Land BB, Li S, Pintar JE, Chavkin C. Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 787-94. PMID 16123754 DOI: 10.1038/Sj.Npp.1300860  0.712
2006 McLaughlin JP, Li S, Valdez J, Chavkin TA, Chavkin C. Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1241-8. PMID 16123746 DOI: 10.1038/Sj.Npp.1300872  0.447
2005 Ippolito DL, Xu M, Bruchas MR, Wickman K, Chavkin C. Tyrosine phosphorylation of K(ir)3.1 in spinal cord is induced by acute inflammation, chronic neuropathic pain, and behavioral stress. The Journal of Biological Chemistry. 280: 41683-93. PMID 16223722 DOI: 10.1074/Jbc.M507069200  0.762
2005 Petraschka M, Gilbert T, Westenbroek R, Li S, Chavkin C. Endogenous β-endorphin selectively activates and induces the phosphorylation of mu opioid receptors in striatum The Journal of Pain. 6: S8. DOI: 10.1016/J.JPAIN.2005.01.030  0.479
2004 Luk T, Jin W, Zvonok A, Lu D, Lin XZ, Chavkin C, Makriyannis A, Mackie K. Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist. British Journal of Pharmacology. 142: 495-500. PMID 15148260 DOI: 10.1038/Sj.Bjp.0705792  0.407
2004 Xu M, Petraschka M, McLaughlin JP, Westenbroek RE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Terman GW, Chavkin C. Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4576-84. PMID 15140929 DOI: 10.1523/Jneurosci.5552-03.2004  0.458
2004 Celver J, Xu M, Jin W, Lowe J, Chavkin C. Distinct domains of the mu-opioid receptor control uncoupling and internalization. Molecular Pharmacology. 65: 528-37. PMID 14978231 DOI: 10.1124/Mol.65.3.528  0.791
2004 Chavkin C, Sud S, Jin W, Stewart J, Zjawiony JK, Siebert DJ, Toth BA, Hufeisen SJ, Roth BL. Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. The Journal of Pharmacology and Experimental Therapeutics. 308: 1197-203. PMID 14718611 DOI: 10.1124/jpet.103.059394  0.497
2004 Terman GW, Jin W, Cheong YP, Lowe J, Caron MG, Lefkowitz RJ, Chavkin C. G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. British Journal of Pharmacology. 141: 55-64. PMID 14662727 DOI: 10.1038/Sj.Bjp.0705595  0.509
2004 McLaughlin JP, Myers LC, Zarek PE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Chavkin C. Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. The Journal of Biological Chemistry. 279: 1810-8. PMID 14597630 DOI: 10.1074/Jbc.M305796200  0.47
2003 McLaughlin JP, Marton-Popovici M, Chavkin C. Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5674-83. PMID 12843270  0.359
2003 McLaughlin JP, Xu M, Mackie K, Chavkin C. Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. The Journal of Biological Chemistry. 278: 34631-40. PMID 12815037 DOI: 10.1074/Jbc.M304022200  0.491
2003 McLaughlin JP, Marton-Popovici M, Chavkin C. κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses The Journal of Neuroscience. 23: 5674-5683. DOI: 10.1523/Jneurosci.23-13-05674.2003  0.462
2002 Ippolito DL, Temkin PA, Rogalski SL, Chavkin C. N-terminal tyrosine residues within the potassium channel Kir3 modulate GTPase activity of Galphai. The Journal of Biological Chemistry. 277: 32692-6. PMID 12082117 DOI: 10.1074/Jbc.M204407200  0.809
2002 Lowe JD, Celver JP, Gurevich VV, Chavkin C. mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin. The Journal of Biological Chemistry. 277: 15729-35. PMID 11861651 DOI: 10.1074/Jbc.M200612200  0.804
2002 Celver J, Vishnivetskiy SA, Chavkin C, Gurevich VV. Conservation of the phosphate-sensitive elements in the arrestin family of proteins. The Journal of Biological Chemistry. 277: 9043-8. PMID 11782458 DOI: 10.1074/Jbc.M107400200  0.756
2001 Svingos AL, Chavkin C, Colago EE, Pickel VM. Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Synapse (New York, N.Y.). 42: 185-92. PMID 11746715 DOI: 10.1002/syn.10005  0.561
2001 Chavkin C, McLaughlin JP, Celver JP. Regulation of opioid receptor function by chronic agonist exposure: constitutive activity and desensitization. Molecular Pharmacology. 60: 20-5. PMID 11408596 DOI: 10.1124/Mol.60.1.20  0.784
2001 McLaughlin JP, Chavkin C. Tyrosine phosphorylation of the mu-opioid receptor regulates agonist intrinsic efficacy. Molecular Pharmacology. 59: 1360-8. PMID 11353794 DOI: 10.1124/Mol.59.6.1360  0.455
2001 Rogalski SL, Chavkin C. Eicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating site. The Journal of Biological Chemistry. 276: 14855-60. PMID 11278615 DOI: 10.1074/Jbc.M010097200  0.79
2001 Terman GW, Eastman CL, Chavkin C. Mu opiates inhibit long-term potentiation induction in the spinal cord slice. Journal of Neurophysiology. 85: 485-94. PMID 11160487 DOI: 10.1152/Jn.2001.85.2.485  0.372
2001 Celver JP, Lowe J, Kovoor A, Gurevich VV, Chavkin C. Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes. The Journal of Biological Chemistry. 276: 4894-900. PMID 11060299 DOI: 10.1074/Jbc.M007437200  0.797
2000 Appleyard SM, McLaughlin JP, Chavkin C. Tyrosine phosphorylation of the kappa -opioid receptor regulates agonist efficacy. The Journal of Biological Chemistry. 275: 38281-5. PMID 10995763 DOI: 10.1074/Jbc.M006756200  0.759
2000 Terman GW, Drake CT, Simmons ML, Milner TA, Chavkin C. Opioid modulation of recurrent excitation in the hippocampal dentate gyrus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4379-88. PMID 10844006 DOI: 10.1523/Jneurosci.20-12-04379.2000  0.435
2000 Rogalski SL, Appleyard SM, Pattillo A, Terman GW, Chavkin C. TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel. The Journal of Biological Chemistry. 275: 25082-8. PMID 10833508 DOI: 10.1074/Jbc.M000183200  0.788
1999 Appleyard SM, Celver J, Pineda V, Kovoor A, Wayman GA, Chavkin C. Agonist-dependent desensitization of the kappa opioid receptor by G protein receptor kinase and beta-arrestin. The Journal of Biological Chemistry. 274: 23802-7. PMID 10446141 DOI: 10.1074/Jbc.274.34.23802  0.75
1999 Jin W, Brown S, Roche JP, Hsieh C, Celver JP, Kovoor A, Chavkin C, Mackie K. Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 3773-80. PMID 10234009 DOI: 10.1523/Jneurosci.19-10-03773.1999  0.77
1999 Rogalski SL, Cyr C, Chavkin C. Activation of the endothelin receptor inhibits the G protein-coupled inwardly rectifying potassium channel by a phospholipase A2-mediated mechanism. Journal of Neurochemistry. 72: 1409-16. PMID 10098843 DOI: 10.1046/J.1471-4159.1999.721409.X  0.823
1999 Kovoor A, Celver J, Abdryashitov RI, Chavkin C, Gurevich VV. Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells. The Journal of Biological Chemistry. 274: 6831-4. PMID 10066734 DOI: 10.1074/Jbc.274.11.6831  0.766
1998 Kovoor A, Celver JP, Wu A, Chavkin C. Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy. Molecular Pharmacology. 54: 704-11. PMID 9765514  0.782
1997 Appleyard SM, Patterson TA, Jin W, Chavkin C. Agonist-induced phosphorylation of the kappa-opioid receptor. Journal of Neurochemistry. 69: 2405-12. PMID 9375672 DOI: 10.1046/j.1471-4159.1997.69062405.x  0.679
1997 Drake CT, Chavkin C, Milner TA. Kappa opioid receptor-like immunoreactivity is present in substance P-containing subcortical afferents in guinea pig dentate gyrus. Hippocampus. 7: 36-47. PMID 9138667 DOI: 10.1002/(Sici)1098-1063(1997)7:1<36::Aid-Hipo4>3.0.Co;2-5  0.342
1997 Jin W, Terman GW, Chavkin C. Kappa opioid receptor tolerance in the guinea pig hippocampus. The Journal of Pharmacology and Experimental Therapeutics. 281: 123-8. PMID 9103488  0.385
1996 Drake CT, Patterson TA, Simmons ML, Chavkin C, Milner TA. Kappa opioid receptor-like immunoreactivity in guinea pig brain: ultrastructural localization in presynaptic terminals in hippocampal formation. The Journal of Comparative Neurology. 370: 377-95. PMID 8799863 DOI: 10.1002/(Sici)1096-9861(19960701)370:3<377::Aid-Cne8>3.0.Co;2-1  0.347
1996 Hell JW, Westenbroek RE, Breeze LJ, Wang KK, Chavkin C, Catterall WA. N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 93: 3362-7. PMID 8622942 DOI: 10.1073/pnas.93.8.3362  0.319
1995 Kovoor A, Henry DJ, Chavkin C. Agonist-induced desensitization of the mu opioid receptor-coupled potassium channel (GIRK1). The Journal of Biological Chemistry. 270: 589-95. PMID 7822283 DOI: 10.1074/Jbc.270.2.589  0.461
1995 Henry DJ, Chavkin C. Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes. Neuroscience Letters. 186: 91-4. PMID 7777206 DOI: 10.1016/0304-3940(95)11289-9  0.389
1995 Henry DJ, Grandy DK, Lester HA, Davidson N, Chavkin C. Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes. Molecular Pharmacology. 47: 551-7. PMID 7700253  0.375
1995 Hell JW, Yokoyama CT, Breeze LJ, Chavkin C, Catterall WA. Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neurons. The Embo Journal. 14: 3036-44. PMID 7621818 DOI: 10.1002/J.1460-2075.1995.Tb07306.X  0.323
1995 Simmons ML, Terman GW, Gibbs SM, Chavkin C. L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells. Neuron. 14: 1265-72. PMID 7605635 DOI: 10.1016/0896-6273(95)90273-2  0.343
1995 Bausch SB, Patterson TA, Appleyard SM, Chavkin C. Immunocytochemical localization of delta opioid receptors in mouse brain. Journal of Chemical Neuroanatomy. 8: 175-89. PMID 7598816 DOI: 10.1016/0891-0618(94)00044-T  0.679
1995 Dascal N, Doupnik CA, Ivanina T, Bausch S, Wang W, Lin C, Garvey J, Chavkin C, Lester HA, Davidson N. Inhibition of function in Xenopus oocytes of the inwardly rectifying G-protein-activated atrial K channel (GIRK1) by overexpression of a membrane-attached form of the C-terminal tail. Proceedings of the National Academy of Sciences of the United States of America. 92: 6758-62. PMID 7542774 DOI: 10.1073/Pnas.92.15.6758  0.325
1994 Caudle RM, Chavkin C, Dubner R. Kappa 2 opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 5580-9. PMID 7916046 DOI: 10.1523/Jneurosci.14-09-05580.1994  0.654
1994 Terman GW, Wagner JJ, Chavkin C. Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 4740-7. PMID 7913954 DOI: 10.1523/Jneurosci.14-08-04740.1994  0.515
1994 Drake CT, Terman GW, Simmons ML, Milner TA, Kunkel DD, Schwartzkroin PA, Chavkin C. Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 3736-50. PMID 7911518 DOI: 10.1523/Jneurosci.14-06-03736.1994  0.371
1994 Simmons ML, Terman GW, Drake CT, Chavkin C. Inhibition of glutamate release by presynaptic kappa 1-opioid receptors in the guinea pig dentate gyrus. Journal of Neurophysiology. 72: 1697-705. PMID 7823095 DOI: 10.1152/Jn.1994.72.4.1697  0.411
1994 Patterson TA, Connor M, Appleyard SM, Chavkin C. Oocytes from Xenopus laevis contain an intrinsic sigma 2-like binding site. Neuroscience Letters. 180: 159-62. PMID 7700571 DOI: 10.1016/0304-3940(94)90511-8  0.715
1993 Wagner JJ, Terman GW, Chavkin C. Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus. Nature. 363: 451-4. PMID 8099201 DOI: 10.1038/363451A0  0.515
1992 Simmons ML, Wagner JJ, Caudle RM, Chavkin C. Endogenous opioid regulation of norepinephrine release in guinea pig hippocampus. Neuroscience Letters. 141: 84-8. PMID 1508405 DOI: 10.1016/0304-3940(92)90340-D  0.755
1992 Connor MA, Chavkin C. Ionic zinc may function as an endogenous ligand for the haloperidol-sensitive sigma 2 receptor in rat brain. Molecular Pharmacology. 42: 471-9. PMID 1406599  0.429
1992 Wagner JJ, Caudle RM, Chavkin C. Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 132-41. PMID 1345943 DOI: 10.1523/Jneurosci.12-01-00132.1992  0.766
1992 Wagner JJ, Chavkin C. Endogenous opioids and LTP: another view. Neurochemistry International. 20: 457-60. PMID 1339017 DOI: 10.1016/0197-0186(92)90022-J  0.515
1991 Caudle RM, Wagner JJ, Chavkin C. Endogenous opioids released from perforant path modulate norepinephrine actions and inhibitory postsynaptic potentials in guinea pig CA3 pyramidal cells. The Journal of Pharmacology and Experimental Therapeutics. 258: 18-26. PMID 2072294  0.725
1991 Connor MA, Chavkin C. Focal stimulation of specific pathways in the rat hippocampus causes a reduction in radioligand binding to the haloperidol-sensitive sigma receptor. Experimental Brain Research. 85: 528-36. PMID 1680737 DOI: 10.1007/BF00231736  0.505
1991 Wagner JJ, Evans CJ, Chavkin C. Focal stimulation of the mossy fibers releases endogenous dynorphins that bind kappa 1-opioid receptors in guinea pig hippocampus. Journal of Neurochemistry. 57: 333-43. PMID 1675664 DOI: 10.1111/J.1471-4159.1991.Tb02132.X  0.515
1990 Wimpey TL, Caudle RM, Chavkin C. Chronic morphine exposure blocks opioid effects on both the early and late inhibitory postsynaptic potentials in hippocampal CA1 pyramidal cells. Neuroscience Letters. 110: 349-55. PMID 2158024 DOI: 10.1016/0304-3940(90)90872-7  0.675
1990 Caudle RM, Swearengen E, Chavkin C. Endogenously released opioids inhibit inhibitory post synaptic potentials in guinea pig CA3 pyramidal cells and rat dentate granule cells. Progress in Clinical and Biological Research. 328: 5-8. PMID 2154812  0.603
1990 Wagner JJ, Caudle RM, Neumaier JF, Chavkin C. Stimulation of endogenous opioid release displaces mu receptor binding in rat hippocampus. Neuroscience. 37: 45-53. PMID 1978741 DOI: 10.1016/0306-4522(90)90190-F  0.816
1990 Caudle RM, Chavkin C. Mu opioid receptor activation reduces inhibitory postsynaptic potentials in hippocampal CA3 pyramidal cells of rat and guinea pig. The Journal of Pharmacology and Experimental Therapeutics. 252: 1361-9. PMID 1969476  0.597
1989 Neumaier JF, Chavkin C. Release of endogenous opioid peptides displaces [3H]diprenorphine binding in rat hippocampal slices. Brain Research. 493: 292-302. PMID 2765901 DOI: 10.1016/0006-8993(89)91164-5  0.584
1989 Neumaier JF, Chavkin C. Calcium-dependent displacement of haloperidol-sensitive sigma receptor binding in rat hippocampal slices following tissue depolarization. Brain Research. 500: 215-22. PMID 2557959 DOI: 10.1016/0006-8993(89)90316-8  0.584
1988 Chavkin C, Neumaier JF, Swearengen E. Opioid receptor mechanisms in the rat hippocampus. Nida Research Monograph. 82: 94-117. PMID 2899843  0.542
1988 Neumaier JF, Mailheau S, Chavkin C. Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus. The Journal of Pharmacology and Experimental Therapeutics. 244: 564-70. PMID 2894454  0.542
1986 Cox BM, Chavkin C. Properties of receptors mediating opioid effects: discrimination of receptor types. Nida Research Monograph. 71: 1-18. PMID 3025728  0.478
1986 Siggins GR, Henriksen SJ, Chavkin C, Gruol D. Opioid peptides and epileptogenesis in the limbic system: cellular mechanisms. Advances in Neurology. 44: 501-12. PMID 2939697  0.652
1986 Neumaier JF, Chavkin C. Opioid receptor activity in the dentate region of the rat hippocampus. Nida Research Monograph. 75: 101-4. PMID 2893261  0.542
1986 Chavkin C, Bloom FE. Opiate antagonists do not alter neuronal responses to stimulation of opioid-containing pathways in rat hippocampus. Neuropeptides. 7: 19-22. PMID 2869440 DOI: 10.1016/0143-4179(86)90074-0  0.543
1985 Chavkin C, Shoemaker WJ, McGinty JF, Bayon A, Bloom FE. Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 808-16. PMID 3838345  0.498
1985 Chavkin C, Henriksen SJ, Siggins GR, Bloom FE. Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-A and -B may act on mu-receptors in the CA1 region. Brain Research. 331: 366-70. PMID 2859095 DOI: 10.1016/0006-8993(85)91565-3  0.779
1985 Chavkin C, Shoemaker W, McGinty J, Bayon A, Bloom F. Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus The Journal of Neuroscience. 5: 808-816. DOI: 10.1523/JNEUROSCI.05-03-00808.1985  0.634
1984 Chavkin C, Goldstein A. Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus. Proceedings of the National Academy of Sciences of the United States of America. 81: 7253-7. PMID 6095280 DOI: 10.1073/Pnas.81.22.7253  0.541
1983 Chavkin C, Bakhit C, Weber E, Bloom FE. Relative contents and concomitant release of prodynorphin/neoendorphin-derived peptides in rat hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 80: 7669-73. PMID 6143317 DOI: 10.1073/PNAS.80.24.7669  0.443
1983 Gruol DL, Chavkin C, Valentino RJ, Siggins GR. Dynorphin-A alters the excitability of pyramidal neurons of the rat hippocampus in vitro. Life Sciences. 33: 533-6. PMID 6141499 DOI: 10.1016/0024-3205(83)90558-1  0.635
1983 Chavkin C, Bakhit C, Bloom FE. Evidence for dynorphin-A as a neurotransmitter in rat hippocampus. Life Sciences. 33: 13-6. PMID 6141483 DOI: 10.1016/0024-3205(83)90432-0  0.399
1983 Cox BM, Chavkin C. Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency. Molecular Pharmacology. 23: 36-43. PMID 6135144  0.478
1982 Chavkin C, Goldstein A. Reduction in opiate receptor reserve in morphine tolerant guinea pig ilea. Life Sciences. 31: 1687-90. PMID 6296572 DOI: 10.1016/0024-3205(82)90186-2  0.489
1982 James IF, Chavkin C, Goldstein A. Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin. Proceedings of the National Academy of Sciences of the United States of America. 79: 7570-4. PMID 6130527 DOI: 10.1073/Pnas.79.23.7570  0.541
1982 James IF, Chavkin C, Goldstein A. Selectivity of dynorphin for kappa opioid receptors. Life Sciences. 31: 1331-4. PMID 6128656 DOI: 10.1016/0024-3205(82)90374-5  0.489
1982 Chavkin C, James IF, Goldstein A. Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science (New York, N.Y.). 215: 413-5. PMID 6120570 DOI: 10.1126/Science.6120570  0.666
1982 Chavkin C, James IF, Goldstein A. Dynorphin is a specific endogenous ligand of the κ opioid receptor Pain. 14: 201. DOI: 10.1016/0304-3959(82)90120-8  0.541
1981 Chavkin C, Goldstein A. Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus. Nature. 291: 591-3. PMID 6264311 DOI: 10.1038/291591a0  0.489
1981 Chavkin C, Goldstein A. Specific receptor for the opioid peptide dynorphin: structure--activity relationships. Proceedings of the National Academy of Sciences of the United States of America. 78: 6543-7. PMID 6118865 DOI: 10.1073/Pnas.78.10.6543  0.541
1980 Cox BM, Leslie FM, Chavkin C. Characteristics of peptide and alkaloid opiate binding sites in brain and peripheral tissues. Advances in Biochemical Psychopharmacology. 22: 353-62. PMID 6249080  0.478
1980 Leslie FM, Chavkin C, Cox BM. Opioid binding properties of brain and peripheral tissues: evidence for heterogeneity in opioid ligand binding sites. The Journal of Pharmacology and Experimental Therapeutics. 214: 395-402. PMID 6248635  0.478
1980 Ghazarossian VE, Chavkin C, Goldstein A. A specific radioimmunoassay for the novel opioid peptide dynorphin. Life Sciences. 27: 75-86. PMID 6105608 DOI: 10.1016/0024-3205(80)90021-1  0.489
1980 Ho WKK, Cox BM, Chavkin C, Goldstein A. Opioid peptide dynorphin-(1-13): Adsorptive losses and potency estimates Neuropeptides. 1: 143-152.  0.632
1979 Chavkin C, Cox BM, Goldstein A. Stereospecific opiate binding in bovine adrenal medulla. Molecular Pharmacology. 15: 751-3. PMID 226864  0.478
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